MCID: ACT071
MIFTS: 54

Acute Kidney Failure

Categories: Nephrological diseases

Aliases & Classifications for Acute Kidney Failure

MalaCards integrated aliases for Acute Kidney Failure:

Name: Acute Kidney Failure 37 12 14
Pre-Renal Acute Kidney Injury 69
Kidney Failure, Acute 69
Acute Renal Failure 72
Renal Failure Acute 51

Classifications:



External Ids:

Disease Ontology 12 DOID:3021
ICD10 32 N17 N17.1 N17.2

Summaries for Acute Kidney Failure

MalaCards based summary : Acute Kidney Failure, also known as pre-renal acute kidney injury, is related to metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration and malignant hypertension. An important gene associated with Acute Kidney Failure is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Dopamine and Fenoldopam have been mentioned in the context of this disorder. Affiliated tissues include Bone and Adipose, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Acute kidney injury (AKI), previously called acute renal failure (ARF), is an abrupt loss of kidney... more...

Related Diseases for Acute Kidney Failure

Diseases in the Kidney Disease family:

Acute Kidney Failure Chronic Kidney Failure
Renal Infectious Disease

Diseases related to Acute Kidney Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 30.4 MB PIK3C2A
2 malignant hypertension 29.4 ADAMTS13 NPPA REN
3 kidney disease 29.0 ALB B2M CST3 NPPA REN
4 acute kidney tubular necrosis 28.9 ALB HAVCR1 HGF IL18 MB NPPA
5 kidney cortex necrosis 11.0
6 phosphoribosylpyrophosphate synthetase superactivity 10.9
7 korean hemorrhagic fever 10.9
8 hemolytic-uremic syndrome 10.9
9 mercury poisoning 10.5 B2M IL18
10 tricuspid valve prolapse 10.5 EGF PIK3C2A
11 virus associated hemophagocytic syndrome 10.4 MB PIK3C2A
12 immunodeficiency 43 10.4 ALB B2M
13 interstitial myocarditis 10.4 MB PIK3C2A
14 creatine phosphokinase, elevated serum 10.4 MB PIK3C2A
15 posterior myocardial infarction 10.3 MB PIK3C2A
16 hypoaldosteronism 10.3 NPPA REN
17 burns 10.3 ALB HGF
18 postural hypotension 10.3 NPPA REN
19 diffuse glomerulonephritis 10.3 ALB B2M
20 renal artery disease 10.3 NPPA REN
21 anteroseptal myocardial infarction 10.3 ALB PIK3C2A
22 non-secretory myeloma 10.3 ALB B2M
23 benign essential hypertension 10.3 ALB REN
24 chronic ulcer of skin 10.2 ALB EGF
25 kidney papillary necrosis 10.2 ALB REN
26 hydronephrosis 10.2 ALB B2M EGF
27 myositis fibrosa 10.2 MB PIK3C2A
28 acute myocardial infarction 10.2 MB NPPA PIK3C2A
29 pericardial effusion 10.2 NPPA PIK3C2A REN
30 compartment syndrome 10.2 ALB MB PIK3C2A
31 diffuse meningeal melanocytosis 10.2 HGF TYR
32 noma 10.2 ALB IL18
33 coronary artery anomaly 10.2 MB NPPA PIK3C2A
34 syndrome of inappropriate antidiuretic hormone 10.2 ALB NPPA
35 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 MB PIK3C2A REN
36 orthostatic proteinuria 10.1 ALB B2M REN
37 congestive heart failure 10.1 NPPA PIK3C2A REN
38 homocystinuria due to cystathionine beta-synthase deficiency 10.1 CST3 TYR
39 obstructive jaundice 10.1 ALB HGF REN
40 pyelitis 10.1 B2M REN
41 disseminated intravascular coagulation 10.1 ADAMTS13 MB PIK3C2A
42 arteries, anomalies of 10.0 ALB MB REN
43 renal tuberculosis 10.0 B2M REN
44 autosomal dominant polycystic kidney disease 10.0 ALB EGF REN
45 plexopathy 9.9 MB PIK3C2A
46 urinary tract obstruction 9.9 ALB B2M EGF REN
47 liver cirrhosis 9.9 ALB HGF NPPA REN
48 anuria 9.9 ALB MB PIK3C2A REN
49 thrombotic thrombocytopenic purpura, congenital 9.9 ADAMTS13 CFH
50 chronic kidney failure 9.8 ALB B2M CST3 REN

Comorbidity relations with Acute Kidney Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 100)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Myocardial Infarction
Acute Pancreatitis Acute Proliferative Glomerulonephritis
Acute Vascular Insufficiency of Intestine Alcoholic Liver Cirrhosis
Alzheimer Disease Aortic Aneurysm
Aortic Valve Disease 1 Bacteremia 2
Benign Renovascular Hypertension Bladder Cancer
Bladder Neck Obstruction Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Rapidly Progressive Glomerulonephritis Colorectal Cancer
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Disseminated Intravascular Coagulation
Encephalopathy Esophageal Candidiasis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Goodpasture Syndrome
Gout Heart Disease
Hemolytic-Uremic Syndrome Hepatic Encephalopathy
Hepatitis Hepatorenal Syndrome
Hydronephrosis Hypertension, Essential
Hypertensive Encephalopathy Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypoglycemia Hypoglycemic Coma

Graphical network of the top 20 diseases related to Acute Kidney Failure:



Diseases related to Acute Kidney Failure

Symptoms & Phenotypes for Acute Kidney Failure

MGI Mouse Phenotypes related to Acute Kidney Failure:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 B2M CFH CST3 HGF IL18 MB
2 hematopoietic system MP:0005397 9.96 MB NPPA PIK3C2A REN SLC22A12 ADAMTS13
3 homeostasis/metabolism MP:0005376 9.93 ADAMTS13 ALB B2M CFH CST3 IL18
4 mortality/aging MP:0010768 9.73 ADAMTS13 ALB B2M CFH CST3 HGF
5 renal/urinary system MP:0005367 9.17 ALB CFH NPPA PIK3C2A REN SLC22A12

Drugs & Therapeutics for Acute Kidney Failure

Drugs for Acute Kidney Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 595)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Fenoldopam Approved Phase 4,Phase 3,Phase 2 67227-56-9, 67227-57-0 3341
3
Pirfenidone Approved, Investigational Phase 4 53179-13-8 40632
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
5
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 46507594 772
6
Everolimus Approved Phase 4,Phase 3,Phase 2 159351-69-6 6442177
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
8
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
9
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
10
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 53-03-2 5865
11
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2 53123-88-9 46835353 6436030 5284616
12
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
13
Alprostadil Approved, Investigational Phase 4 745-65-3 149351
14
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 616-91-1 12035
15
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
16
Nafamostat Approved, Investigational Phase 4,Phase 3 81525-10-2
17
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
18
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
19
Dalteparin Approved Phase 4,Phase 3 9005-49-6
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
22
Simvastatin Approved Phase 4,Phase 1 79902-63-9 54454
23
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
24
Enalaprilat Approved Phase 4 76420-72-9 6917719
25
Ramipril Approved Phase 4,Phase 2,Phase 3 87333-19-5 5362129
26
Daptomycin Approved, Investigational Phase 4,Phase 3 103060-53-3 16129629
27
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
28
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
29
Remifentanil Approved Phase 4 132875-61-7 60815
30
Desflurane Approved Phase 4 57041-67-5 42113
31
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
32
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
33
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 54-31-9 3440
34
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
35
Cisplatin Approved Phase 4,Phase 2,Phase 3,Phase 1 15663-27-1 2767 441203 84093
36
Milrinone Approved Phase 4,Phase 2 78415-72-2 4197
37
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
38
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
39
Vancomycin Approved Phase 4,Phase 3,Phase 1 1404-90-6 14969 441141
40
Piperacillin Approved Phase 4,Phase 1 66258-76-2 43672
41
Tazobactam Approved Phase 4,Phase 1 89786-04-9 123630
42
Spironolactone Approved Phase 4,Phase 2,Phase 3 1952-01-7, 52-01-7 5833
43
Metolazone Approved Phase 4 17560-51-9 4170
44
Aminophylline Approved Phase 4,Early Phase 1 317-34-0 9433
45
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5282411 5280427
46
Terlipressin Approved, Investigational Phase 4,Phase 2 14636-12-5 72081
47
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
48 Nadroparin Approved, Investigational Phase 4 9041-08-1
49
Thrombin Approved, Investigational Phase 4,Phase 3
50
Mannitol Approved, Investigational Phase 4,Phase 2 69-65-8 6251 453

Interventional clinical trials:

(show top 50) (show all 1082)

# Name Status NCT ID Phase Drugs
1 Fenoldopam for Prevention of Acute Kidney Injury Unknown status NCT01690832 Phase 4 standard saline infusion;fenoldopam infusion
2 Pirfenidone Effect on the Recovery of Renal Function in Septic Acute Kidney Injury Unknown status NCT02530359 Phase 4 Pirfenidone extended release;Placebo equivalent
3 Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes Unknown status NCT01978405 Phase 4 Alpha lipoic acid
4 Early Continuous Renal Replacement Therapies (CRRT) in Patients With Severe Sepsis or Septic Shock With Acute Kidney Injury Unknown status NCT00837057 Phase 4
5 The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery Unknown status NCT01886079 Phase 4 dexmedetomidine;Saline
6 Limiting IV Chloride to Reduce AKI After Cardiac Surgery Unknown status NCT02020538 Phase 4
7 Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU Unknown status NCT01962116 Phase 4 Citrate 4%;unfractionated heparin
8 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4 Unfractionated heparin;Citrasate
9 Protective Effects of Oral L-Arginine CI-AKI Unknown status NCT02455960 Phase 4
10 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
11 Cytokines Evaluation in Early Calcineurin Inhibitors Withdrawn on Renal Transplant Unknown status NCT01239472 Phase 4 everolimus
12 Efficacy and Safety of Alprostadil Prevent Contrast Induced Nephropathy Unknown status NCT01722513 Phase 4 Alprostadil ﹠control
13 Effect of the Intensity of Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury Completed NCT01560650 Phase 4
14 Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft Completed NCT01394419 Phase 4 N-acetylcysteine;Saline
15 Augmented Vs. Normal Renal Replacement Therapy in Severe Acute Renal Failure (ARF). Completed NCT00221013 Phase 4
16 Metabolic Pattern of Cyclosporine A and Acute Renal Failure Completed NCT00264355 Phase 4 cyclosporine A
17 The Effect of Atorvastatin on Prevention of Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery Completed NCT02157337 Phase 4 Atorvastatin;placebo
18 The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study Completed NCT00675818 Phase 4
19 Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2) Completed NCT01870804 Phase 4 Rosuvastatin;Atorvastatin
20 Hannover Dialysis Outcome Study Completed NCT00529139 Phase 4
21 Aminophylline and Contrast Induced Nephropathy in Acute Myocardial Infarction Completed NCT01594489 Phase 4 Aminophylline;Hydration plus N-acetylcisteine
22 Prostacyclin's Effect on Platelet Responsiveness Completed NCT00890214 Phase 4 prostacyclin;heparin
23 Prevention of Acute Kidney Injury by Erythropoietin in Thoracic Aorta Surgery With Hypothermic Cardiac Arrest Completed NCT01369732 Phase 4 recombinant human erythropoietin;saline
24 Rosuvastatin Prevent Contrast Induced Acute Kidney Injury in Patients With Diabetes Completed NCT00786136 Phase 4 rosuvastatin
25 Personalized Versus Standard Hydration for Prevention of CI-AKI: a Randomized Trial With Bioimpedance Analysis Completed NCT02225431 Phase 4 sodium chloride infusion
26 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
27 Early Hydration in Acute Myocardial Infarction Completed NCT01742130 Phase 4 sodium bicarbonate solution;Isotonic saline
28 Efficacy of RIPC to Reduce AKI for Patients Undergoing PCI Completed NCT02195726 Phase 4
29 Perioperative Evaluation of Terlipressin Infusion During Living Donor Liver Transplantation on Incidence of Acute Kidney Completed NCT02059460 Phase 4 Terlipressin;placebo
30 Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury Completed NCT02641938 Phase 4 Dexmedetomidine;Normal Saline
31 Trial to Assess the Efficacy and Safety of Nafamostat Mesilate During Continuous Renal Replacement Therapy Completed NCT02478242 Phase 4 Nafamostat mesilate;Normal saline
32 Pharmacokinetics of Ertapenem in Continuous Venovenous Hemodialysis Completed NCT00877370 Phase 4 ertapenem
33 A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial Completed NCT02009280 Phase 4 Administration of anesthesia: Propofol;Administration of anesthesia: Sevoflurane
34 The Effect of Nafamostat Mesilate in Prolonging Filter Patency With Patients on Continuous Renal Replacement Therapy Completed NCT01761994 Phase 4 Anticoagulation with nafamostat mesilate
35 Nadroparin Anticoagulation for Continuous Venovenous Hemofiltration Completed NCT00965328 Phase 4
36 Biological and Clinical Measurements Following Systemic Leakage When a Citrate or Heparin Lock is Used Completed NCT02860299 Phase 4 citrate 4%;unfractionated heparin
37 CUstodiol Versus RInger: whaT Is the Best Agent? Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
38 IVUS Guidance to Reduce Contrast in Coronary Angioplasty Completed NCT01947335 Phase 4
39 Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration Completed NCT01866397 Phase 4
40 PROMISS: Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography Completed NCT00259441 Phase 4 Simvastatin
41 INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery Completed NCT01020409 Phase 4
42 Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery Completed NCT01669434 Phase 4 ACEI continuation;ACEI omission
43 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
44 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
45 Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD) Completed NCT00663403 Phase 4 Daptomycin
46 Everolimus in de Novo Heart Transplant Recipients Completed NCT01017029 Phase 4 Everolimus;Mycophenolate mofetil + Everolimus
47 A Randomized Trial of Rosuvastatin in Elective Angioplasty to Prevent Contrast-induced Nephropathy (CLEAR-CIN). Completed NCT02737319 Phase 4 Rosuvastatin
48 Renal Safety Evaluation After Dotarem®-Enhanced MRI Completed NCT00650845 Phase 4 Dotarem®-enhanced MRI
49 Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01384643 Phase 4 Propofol
50 A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery Completed NCT02113150 Phase 4 remifentanil;Ketamine

Search NIH Clinical Center for Acute Kidney Failure

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Kidney Failure cell therapies at LifeMap Discovery.

Genetic Tests for Acute Kidney Failure

Anatomical Context for Acute Kidney Failure

MalaCards organs/tissues related to Acute Kidney Failure:

38
Kidney, Heart, Liver, Neutrophil, Testes, Endothelial, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Kidney Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
3 Kidney Proximal Tubule Proximal Tubule Cells Potential therapeutic candidate, affected by disease

Publications for Acute Kidney Failure

Articles related to Acute Kidney Failure:

(show all 50)
# Title Authors Year
1
Acute kidney failure due to polyarteritis nodosa. ( 27939915 )
2017
2
Pemetrexed-induced acute kidney failure following irreversible renal damage: two case reports and literature review. ( 28491851 )
2017
3
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure. ( 28551825 )
2017
4
Inhibition of Notch Signaling Ameliorates Acute Kidney Failure and Downregulates Platelet-Derived Growth Factor Receptor I^ in the Mouse Model. ( 26939110 )
2016
5
Hyperkalemia and acute kidney failure associated with preoperative uterine artery embolization for a large uterine fibroid: a case report. ( 27799061 )
2016
6
Clinical case report: a rare cause of acute kidney failure - tissue is the issue. ( 27253186 )
2016
7
Proliferative C4 Dense Deposit Disease, Acute ThromboticA Microangiopathy, a Monoclonal Gammopathy, andA Acute Kidney Failure. ( 26704376 )
2016
8
Acute kidney failure associated with anaphylactic shock caused by diclofenac sodium. ( 25899205 )
2015
9
Elevated biomarkers and contrast-induced acute kidney failure: what comes first the chicken or the egg? ( 25684714 )
2015
10
Tuberous sclerosis presenting with acute kidney failure, pyelonephritis, and polycystic kidney disease. ( 25001142 )
2014
11
Novel presentation of rituximab-induced herpes zoster: urinary retention and acute kidney failure. ( 25079963 )
2014
12
Crohnic kidney disease: recurrent acute kidney failure in a patient with Crohn's disease. ( 25599054 )
2014
13
Successful reversal of acute kidney failure by ultrasound-accelerated thrombolysis of an occluded renal artery. ( 25276140 )
2014
14
Older Adults with CKD and Acute Kidney Failure: Do We Know Enough for Critical Shared Decision Making? ( 24262792 )
2014
15
Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis. ( 23149294 )
2013
16
Joint pain, digital necrosis and acute kidney failure in small-vessel autoimmune disease. ( 26019859 )
2013
17
Acute kidney failure with renal carcinomatous lymphangitis secondary to advanced colon cancer. ( 23903432 )
2013
18
Cardiac catheterization and postoperative acute kidney failure in congenital heart pediatric patients. ( 23780421 )
2013
19
Malignant hypertension with protracted but not definitive oligoanuric acute kidney failure. ( 27293574 )
2013
20
Acute kidney failure complicating carbon monoxide poisoning. ( 22992968 )
2012
21
Renal Replacement Therapy in Acute Kidney Failure due to Rhabdomyolysis. ( 24826338 )
2012
22
New insights in acute kidney failure in the critically ill. ( 22923149 )
2012
23
Primary renal lymphoma: an uncommon diagnosis for acute kidney failure. ( 26019832 )
2012
24
Early biomarkers of acute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure. ( 22130209 )
2012
25
Female with rash, acute kidney failure and rheumatoid arthritis. ( 23023360 )
2012
26
Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure. ( 20811331 )
2011
27
Acute kidney failure in the context of a Tako-Tsubo syndrome. ( 21738255 )
2011
28
Effective use of continuous arteriovenous hemodialysis in a critically ill human immunodeficiency virus-positive patient with acute kidney failure. ( 20622320 )
2010
29
Hemolysis and acute kidney failure. ( 20605299 )
2010
30
Acute kidney failure in neonatal period. ( 19617661 )
2009
31
Acute bacterial pyelonephritis resulting in acute kidney failure: a complication of chronic non-steroidal anti-inflammatory drug use? ( 19335847 )
2009
32
Acute kidney failure in the third trimester of pregnancy. ( 19008026 )
2009
33
Recurrent acute kidney failure due to McArdle disease. ( 19377243 )
2008
34
RIFLE classification of acute kidney failure in intensive care. ( 17639826 )
2007
35
Focus on hepatitis. Low CD4 count + HCV coinfection = acute kidney failure. ( 17366669 )
2006
36
Summaries for patients. Plasma exchange treatment is not effective in treating acute kidney failure caused by multiple myeloma. ( 16330784 )
2005
37
Postpartum acute kidney failure and hyponatremia: a clinical enigma. ( 15473598 )
2004
38
Acute kidney failure: a pediatric experience over 20 years. ( 12197796 )
2002
39
[Acute kidney failure in the course of rhabdomyolysis with hemodialysis in personal material from 1995-1999]. ( 11255648 )
2000
40
Vasculitis with acute kidney failure and torasemide. ( 9863798 )
1998
41
[Acute kidney failure. Non-invasive diagnosis of acute kidney failure in operative intensive care patients]. ( 9567152 )
1998
42
[Plasma myoglobin and continuous hemofiltration in patients with rhabdomyolysis and acute kidney failure]. ( 9297272 )
1997
43
[Urodilatin (INN: ularitide). A new peptide in the treatment of acute kidney failure following liver transplantation]. ( 8702053 )
1996
44
[Experimental models of acute kidney failure]. ( 7569687 )
1995
45
[Acute kidney failure associated with the HELLP syndrome. A case report]. ( 7959159 )
1994
46
Aggressive peritoneal dialysis for treatment of acute kidney failure after neonatal heart transplantation. ( 1576138 )
1992
47
Hyperosmolar nonketotic syndrome associated with rhabdomyolysis and acute kidney failure. ( 2060421 )
1991
48
Dramatic reduction in sandimmune (CyA) dosage may be effective in reversal of severe hyperbilirubinemia and post-transplant acute kidney failure linked to CyA toxicity. ( 3313989 )
1987
49
Acute kidney failure: prerenal, renal, or postrenal? ( 3932406 )
1985
50
Acute kidney failure. ( 13368869 )
1956

Variations for Acute Kidney Failure

Expression for Acute Kidney Failure

Search GEO for disease gene expression data for Acute Kidney Failure.

Pathways for Acute Kidney Failure

Pathways related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 ALB EGF HGF

GO Terms for Acute Kidney Failure

Cellular components related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ALB B2M CFH CST3 EGF IL18
2 extracellular region GO:0005576 9.65 ADAMTS13 ALB B2M CFH CST3 EGF
3 endoplasmic reticulum lumen GO:0005788 9.62 ADAMTS13 ALB B2M CST3
4 platelet alpha granule lumen GO:0031093 9.33 ALB EGF HGF
5 extracellular space GO:0005615 9.32 ADAMTS13 ALB B2M CFH CST3 EGF

Biological processes related to Acute Kidney Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.54 CST3 MB NPPA
2 positive regulation of protein kinase B signaling GO:0051897 9.5 EGF HGF IL18
3 response to drug GO:0042493 9.46 B2M CST3 REN SLC22A12
4 platelet degranulation GO:0002576 9.43 ALB EGF HGF
5 phosphatidylinositol phosphorylation GO:0046854 9.13 EGF HGF PIK3C2A
6 cellular protein metabolic process GO:0044267 8.92 ALB B2M CST3 NPPA

Sources for Acute Kidney Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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