MCID: ACT073
MIFTS: 62

Acute Leukemia malady

Summaries for Acute Leukemia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. these lymphocytes (acute lymphocytic leukemia [all]) or myeloid cells (acute myelocytic leukemia [aml]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia. because they are bloodborne, they can infiltrate various organs and sites, including the liver, spleen, lymph nodes, cns, kidneys, and gonads.

MalaCards: Acute Leukemia, also known as stem cell leukemia, is related to leukemia and myeloid leukemia. An important gene associated with Acute Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are Transcriptional misregulation in cancer and Hematopoietic cell lineage. The compounds retinoic acid and etoposide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, t cells and monocytes, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:63 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

Description from OMIM:46 308960

Aliases & Classifications for Acute Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 46OMIM
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Aliases & Descriptions:

acute leukemia 8 10 44 30
stem cell leukemia 8 10
acute undifferentiated leukemia 60
stem cell leukaemia 8


External Ids:

Disease Ontology8 DOID:12603
ICD9CM27 208.0
NCIt39 C9298, C9300
OMIM46 308960

Related Diseases for Acute Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Leukemia family:

Subacute Leukemia acute leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.2CDKN2B, CD7, HOXA7, HOXA9, IL3RA, TAL1
2myeloid leukemia31.2WT1, FLT3, MPO, DNTT, CDKN2B, HOXA9
3acute lymphocytic leukemia30.8WT1, TCF3, TAL1, IL3RA, FLT3, MPO
4myeloma30.5CDKN2B, DNTT
5breast cancer30.4IL3RA, MTHFR, FLT3, FOXO3
6chronic myeloid leukemia30.3WT1, FOXO3, FLT3, MPO, PRAME, DNTT
7down syndrome30.3MTHFR, FLT3
8megakaryocytic leukemia30.3MKL1, MPO
9sarcoma30.3TAF15, WT1
10non-hodgkin lymphoma30.2FLT3, DNTT, CDKN2B, TAL1
11acute monocytic leukemia30.2MPO
12chronic lymphocytic leukemia30.0FLT3, DNTT, CDKN2B, IL3RA
13myeloid sarcoma30.0MPO
14retinoblastoma30.0CDKN2B, WT1
15myelodysplastic syndromes29.8WT1, FLT3, MPO, DNTT, CDKN2B, HOXA9
16melanoma29.8CDKN2B, PRAME, FLT3
17chronic myeloproliferative disease29.8FLT3
18thyroid cancer29.8FLT3
19leukemia, acute nonlymphocytic29.8DNTT, CD7
20childhood leukemia10.9
21acute myeloid leukemia10.8
22acute t cell leukemia10.7
23t-cell leukemia10.6
24lymphoblastic leukemia10.6
25lymphoid leukemia10.4
26natural killer cell leukemia10.4
27acute undifferentiated leukemia10.4
28aspergillosis10.4
29invasive aspergillosis10.3
30multiple myeloma10.3
31acute biphenotypic leukemia10.3
32graft versus host disease10.3
33candidiasis10.3
34disseminated intravascular coagulation10.2
35hepatitis10.2
36neutropenia10.2
378p11 myeloproliferative syndrome10.2
38central nervous system leukemia10.2
39rhabdomyosarcoma10.2
40sideroblastic anemia10.2
41thymoma10.1
42alveolar rhabdomyosarcoma10.1
43adult lymphoma10.1
44pernicious anemia10.1
45oral candidiasis10.1
46histiocytosis10.1
47hodgkin's lymphoma10.1
48monocytic leukemia10.1
49neuroblastoma10.1
50thrombocytopenia10.1

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to acute leukemia

Clinical Features for Acute Leukemia

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46OMIM
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Clinical features from OMIM:

308960

Drugs & Therapeutics for Acute Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Leukemia

Search NIH Clinical Center for Acute Leukemia

Search CenterWatch for Acute Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:
Promostem

Genetic Tests for Acute Leukemia

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Anatomical Context for Acute Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute Leukemia:

32
Myeloid, T cells, Monocytes, Bone, Bone marrow, B cells, Liver, Endothelial, Breast, Kidney, Spleen, Lung, Lymph node, Skin, Thyroid, Testes, Brain, Nk cells, B lymphoblasts, Testis, Pituitary, Thymus, Colon, Spinal cord, Prostate, Tonsil, Pineal, Small intestine, Whole blood, Smooth muscle, Cerebellum, Heart, Skeletal muscle, Adipocyte, Cervix, Uterus, Placenta, Pancreas, Eye, Tongue, Temporal lobe

Animal Models for Acute Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.2TCF3, WT1, FOXO3, FLT3, MPO, DNTT
2MP:000538712.1DNTT, MPO, FLT3, FOXO3, WT1, CDKN2B
3MP:000538911.4FOXO3, MTHFR, CDKN2B, HOXA9, TCF3, ZNF384
4MP:000538411.4WT1, FOXO3, FLT3, MKL1, DNTT, CDKN2B
5MP:001077111.1MKL1, CDKN2B, HOXA9, TAL1, TCF3

Publications for Acute Leukemia

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50PubMed
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Articles related to Acute Leukemia:

(show top 50)    (show all 10128)
idTitleAuthorsYear
1
Lymphocyte recovery on day 100 after allogeneic hematopoietic stem cell transplant predicts non-relapse mortality in patients with acute leukemia or myelodysplastic syndrome. (23841507)
2013
2
Correspondence: The preventive role of MTR A2756G polymorphisms in childhood acute lymphoblastic leukemia remains inconclusive. (24303783)
2013
3
Growth after hematopoietic stem cell transplantation in children with acute myeloid leukemia. (23341720)
2013
4
Isolated central nervous system relapse presenting as myeloid sarcoma of acute myeloid leukemia after allogeneic peripheral blood stem cell transplantation. (22878457)
2013
5
Hispolon induces apoptosis through JNK1/2-mediated activation of a caspase-8, -9, and -3-dependent pathway in acute myeloid leukemia (AML) cells and inhibits AML xenograft tumor growth in vivo. (24093560)
2013
6
Genomic heterogeneity in acute leukemia. (23363651)
2013
7
Ramsay Hunt syndrome in a girl with acute lymphoblastic leukemia during maintenance therapy. (23459378)
2013
8
Retroperitoneal Ganglioneuroma and Reversible Posterior Leukoencephalopathy in a Child With Acute Lymphoblastic Leukemia. (23669738)
2013
9
Cerebral aspergillus infection in pediatric acute lymphoblastic leukemia induction therapy. (23580827)
2012
10
Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemia. (23259137)
2012
11
CD44 activation enhances acute monoblastic leukemia cell survival via Mcl-1 upregulation. (21993315)
2012
12
BAG1: the guardian of anti-apoptotic proteins in acute myeloid leukemia. (22016818)
2011
13
Detection of WT1 gene in acute myeloid leukemia children by real-time fluorescent quantitative RT-PCR and its clinical significance]. (21867623)
2011
14
Clinical outcome of patients with acute promyelocytic leukemia and FLT3 mutations. (20981678)
2010
15
Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype. (19144660)
2009
16
Conidiobolomycosis in relapsed acute lymphoblastic leukemia. (19731329)
2009
17
Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia. (19778842)
2009
18
Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells. (19734423)
2009
19
Another pedigree with familial acute myeloid leukemia and germline CEBPA mutation. (18946494)
2009
20
Acute lymphoblastic leukemia following severe congenital neutropenia or de novo ALL? (19398129)
2009
21
Polymorphisms of RAD51(G135C) and XRCC3(C241T) genes and correlations thereof with prognosis and clinical outcomes of acute myeloid leukemia]. (18581889)
2008
22
Association of high proliferation in adult T-cell leukemia cells with apoptosis, and expression of p53 protein in acute type ATL. (18434687)
2008
23
Low frequency and variability of FLT3 mutations in Korean patients with acute myeloid leukemia. (18955790)
2008
24
Genetic polymorphism in GST, NAT2, and MTRR and susceptibility to childhood acute leukemia]. (18610829)
2008
25
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? (16960150)
2007
26
Analysis of FLT3 internal tandem duplication and D835 mutations in Chinese acute leukemia patients. (15996732)
2005
27
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. (14983942)
2004
28
WT1 gene expression in acute leukemia patients and its correlation with prognosis]. (12837194)
2003
29
Bone marrow purging studies in acute myelogenous leukemia using the recombinant anti-CD33 immunotoxin HuM195/rGel. (12813444)
2003
30
Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile. (12393441)
2003
31
Risk of myelodysplastic syndrome and acute myeloid leukemia in congenital neutropenias. (11957196)
2002
32
Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia. (11895912)
2002
33
Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors. (12036900)
2002
34
Cell cycle regulatory protein expression in fresh acute myeloid leukemia cells and after drug exposure. (11368357)
2001
35
Methylation of p15 and p16 genes in adult acute leukemia: lack of prognostic significance. (11413509)
2001
36
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. (11222358)
2001
37
Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults. (11253611)
2001
38
Torsade de pointes associated with hypokalemia after anthracycline treatment in a patient with acute lymphocytic leukemia. (10745628)
2000
39
P-glycoprotein and terminal transferase expression identify prognostic subsets within cytogenetic risk classes in acute myeloid leukemia. (10374859)
1999
40
A placebo-controlled study of recombinant human granulocyte-macrophage colony-stimulating factor administered during and after induction treatment for de novo acute myelogenous leukemia in elderly patients. Groupe Ouest Est LeucAcmies AiguA9531581)
1998
41
Treatment of acute myeloid leukemia and myelodysplastic syndrome with orally administered cytarabine ocfosfate and granulocyte colony-stimulating factor. (9114597)
1997
42
Acute myeloid leukemia M2B (subacute myeloid leukemia) in China. (9150353)
1997
43
Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: regulation of Bcl-2 and Bax. (8916965)
1996
44
Characterisation of non-concordance in the T-cell receptor gamma chain genes at presentation and clinical relapse in acute lymphoblastic leukemia. (8289500)
1994
45
Interleukin 2 treatment in acute myelogenous leukemia. (8401249)
1993
46
Acute myeloblastic leukemia with minimal myeloid differentiation (FAB AML-M0): a study of eleven cases. (8161925)
1993
47
The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children. (1596573)
1992
48
Prognostic significance of myeloperoxidase positivity of blast cells in acute myeloblastic leukemia without maturation (FAB: M1): an ECOG study. (2560775)
1989
49
X-linked ichthyosis with acute lymphoblastic leukemia. (3422146)
1988
50
LEUKOPENIA, BONE PAIN, AND BONE NECROSIS IN PATIENTS WITH ACUTE LEUKEMIA: A CLINICOPATHOLOGIC COMPLEX. (14274834)
1965

Genetic Variations for Acute Leukemia

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Expression for genes affiliated with Acute Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Pathways for genes affiliated with Acute Leukemia

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Acute Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3TCF3, TAF15, HOXA9, MPO, FLT3, WT1
211.0FLT3, DNTT, CD7, IL3RA
310.9TCF3, CDKN2B, FOXO3
410.9CDKN2B, DNTT, FOXO3

Compounds for genes affiliated with Acute Leukemia

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44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Acute Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.8MXD1, WT1, FLT3, MPO, MTHFR, DNTT
2etoposide44 49 59 1114.3WT1, FOXO3, FLT3, DNTT, TAL1
3thymidine44 2412.3WT1, FLT3, MTHFR, DNTT, IL3RA
4carboplatin44 49 1113.0DNTT, MTHFR, MPO
5naphthol as-d chloroacetate4410.9DNTT, MPO
6oligonucleotide4410.9TAL1, DNTT, FLT3, FOXO3, WT1
7cytarabine44 49 1112.8FLT3, MPO, CDKN2B
8nitro4410.8MPO, WT1
9gemtuzumab ozogamicin44 1111.8FLT3, WT1

GO Terms for genes affiliated with Acute Leukemia

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16Gene Ontology
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Cellular components related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.2ZNF384, WT1, FOXO3, MPO, PRAME, BAALC
2nucleolusGO:00573011.4BAALC, MKL1, DNTT, TAF15, MXD1, ZNF384

Biological processes related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635111.8FOXO3, PRAME, MKL1, CDKN2B, HOXA7, HOXA9
2positive regulation of transcription from RNA polymerase II promoterGO:04594411.5ZNF384, FOXO3, MKL1, CDKN2B, HOXA7, TAL1
3positive regulation of transcription, DNA-dependentGO:04589311.2WT1, FOXO3, TAL1, TAF15, TCF3
4positive regulation of erythrocyte differentiationGO:04564810.7TAL1, FOXO3
5megakaryocyte differentiationGO:03021910.7TAL1, CDKN2B
6definitive hemopoiesisGO:06021610.4TAL1, HOXA9

Molecular functions related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356511.3ZNF384, TCF3, HOXA9, HOXA7, FOXO3, WT1
2sequence-specific DNA binding transcription factor activityGO:00370011.3TCF3, WT1, FOXO3, MKL1, HOXA7, HOXA9

Products for genes affiliated with Acute Leukemia

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Sources for Acute Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet