MCID: ACT073
MIFTS: 61

Acute Leukemia

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Acute Leukemia

MalaCards integrated aliases for Acute Leukemia:

Name: Acute Leukemia 37 12 28 51 14 69
Acute Undifferentiated Leukemia 69
Undifferentiated Leukemia 69
Stem Cell Leukaemia 12
Stem Cell Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12603
ICD10 32 C95.0 C95.00
ICD9CM 34 208.0
NCIt 46 C9298 C9300

Summaries for Acute Leukemia

Disease Ontology : 12 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia.

MalaCards based summary : Acute Leukemia, also known as acute undifferentiated leukemia, is related to chronic eosinophilic leukemia and childhood leukemia. An important gene associated with Acute Leukemia is BAALC (BAALC, MAP3K1 And KLF4 Binding), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Busulfex and Clolar have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

Related Diseases for Acute Leukemia

Diseases in the Leukemia family:

Acute Leukemia Chronic Leukemia
Subacute Leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 chronic eosinophilic leukemia 32.6 FLT3 KIT WT1
2 childhood leukemia 32.5 ETV6 KMT2A MTHFR RUNX1
3 megakaryocytic leukemia 32.3 JAK2 MPO RUNX1
4 lymphoblastic lymphoma 32.0 DNTT KMT2A MPO
5 acute lymphocytic leukemia 31.9 CSF3 ETV6 GSTM1 MTHFR PAX5 RUNX1
6 leukemia 31.8 BAALC CEBPA CREBBP ETV6 FLT3 JAK2
7 acute promyelocytic leukemia 31.5 ANPEP CD34 CEBPA CSF3 FLT3 MPO
8 lymphoblastic leukemia 30.4 AFF1 ETV6 FLT3 JAK2 PAX5 RUNX1
9 chronic myelomonocytic leukemia 30.1 ETV6 FLT3 JAK2 KIT RUNX1
10 leukemia, acute lymphoblastic 30.1 AFF1 ANPEP CD34 CSF3 DNTT ETV6
11 lymphoid leukemia 30.0 ETV6 KMT2A RUNX1
12 8p11 myeloproliferative syndrome 29.9 FLT3 KIT RUNX1
13 myelodysplastic syndrome 29.9 ANPEP CD34 CSF3 DNTT ETV6 FLT3
14 cytogenetically normal acute myeloid leukemia 29.7 CEBPA FLT3 KMT2A WT1
15 hypereosinophilic syndrome, idiopathic 29.6 KIT WT1
16 leukemia, acute myeloid 29.5 AFF1 ANPEP BAALC CD34 CEBPA CREBBP
17 myeloid leukemia 29.5 BAALC CEBPA CREBBP ETV6 FLT3 KIT
18 lymphoma, non-hodgkin, familial 29.1 CD34 CSF3 DNTT PAX5
19 aplastic anemia 29.0 CD34 CSF3 FLT3 GSTM1
20 myeloid sarcoma 28.7 ANPEP DNTT FLT3 KIT KMT2A MPO
21 myelofibrosis 28.5 CD34 CSF3 FLT3 JAK2 KIT MPO
22 leukemia, chronic myeloid 28.5 CD34 CSF3 DNTT ETV6 FLT3 JAK2
23 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 28.3 CREBBP DNTT ETV6 FLT3 KIT KMT2A
24 leukemia, acute lymphoblastic 3 28.1 AFF1 ANPEP DNTT ETV6 FLT3 KMT2A
25 acute leukemia of ambiguous lineage 12.2
26 chromosome 8p11 myeloproliferative syndrome 11.7
27 invasive aspergillosis 11.2
28 myeloproliferative neoplasm 11.2
29 myelodysplastic myeloproliferative cancer 10.9
30 chronic leukemia 10.9
31 ring chromosome 21 10.6 ETV6 KMT2A
32 acute myeloblastic leukemia with maturation 10.6 FLT3 KIT
33 platelet disorder, familial, with associated myeloid malignancy 10.6 ETV6 RUNX1
34 testicular gonadoblastoma 10.6 KIT WT1
35 acute myeloid leukemia with minimal differentiation 10.5 FLT3 MPO
36 blood coagulation disease 10.5 CSF3 JAK2 MTHFR
37 congenital mesoblastic nephroma 10.5 ETV6 KIT WT1
38 nondisjunction 10.5 KIT MTHFR
39 neonatal leukemia 10.5 AFF1 CREBBP FLT3
40 malignant mesenchymoma 10.5 ETV6 KIT WT1
41 blood platelet disease 10.4 CSF3 JAK2 RUNX1
42 myelophthisic anemia 10.4 ANPEP JAK2
43 mn1 10.4 ETV6 FLT3
44 arteritic anterior ischemic optic neuropathy 10.4 GSTM1 MPO MTHFR
45 acute basophilic leukemia 10.4 ETV6 MPO
46 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.4 CEBPA FLT3 KIT RUNX1
47 acute lymphoblastic leukemia, childhood 10.3 ETV6 FLT3 GSTM1 MTHFR RUNX1
48 gallbladder leiomyoma 10.3 CD34 KIT
49 chromophobe renal cell carcinoma 10.3
50 renal oncocytoma 10.3

Comorbidity relations with Acute Leukemia via Phenotypic Disease Network (PDN):


Deficiency Anemia Neutropenia

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to Acute Leukemia

Symptoms & Phenotypes for Acute Leukemia

MGI Mouse Phenotypes related to Acute Leukemia:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 JAK2 WT1 MPO PAX5 KIT RUNX1
2 immune system MP:0005387 10.31 JAK2 WT1 MPO PAX5 KIT RUNX1
3 homeostasis/metabolism MP:0005376 10.28 KMT2A STMN1 JAK2 MTHFR WT1 MPO
4 cardiovascular system MP:0005385 10.26 KMT2A STMN1 WT1 MPO ETV6 KIT
5 growth/size/body region MP:0005378 10.26 KMT2A JAK2 MTHFR WT1 PAX5 ETV6
6 cellular MP:0005384 10.25 KMT2A JAK2 WT1 PAX5 ETV6 KIT
7 endocrine/exocrine gland MP:0005379 10.19 JAK2 WT1 ETV6 KIT RUNX1 FLT3
8 integument MP:0010771 10.11 JAK2 MTHFR KIT RUNX1 KMT2A CSF3
9 mortality/aging MP:0010768 10.07 KMT2A JAK2 MTHFR MPO WT1 PAX5
10 neoplasm MP:0002006 9.9 JAK2 WT1 PAX5 KIT RUNX1 FLT3
11 liver/biliary system MP:0005370 9.87 KMT2A JAK2 WT1 KIT RUNX1 CEBPA
12 no phenotypic analysis MP:0003012 9.61 KMT2A MTHFR WT1 KIT RUNX1 FLT3
13 normal MP:0002873 9.36 STMN1 JAK2 WT1 PAX5 KIT RUNX1

Drugs & Therapeutics for Acute Leukemia

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Busulfex 17 45 BUSULFAN Orphan Medical February 1999
2
Clolar 17 45 CLOFARABINE Genzyme December, 2004
3
Marqibo 17 45 VINCRISTINE SULFATE Talon Therapeutics August 2012

Drugs for Acute Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 341)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Arsenic trioxide Approved, Investigational Phase 4,Phase 2 1327-53-3 518740
2
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
4
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
5
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 55-98-1 2478
6
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 147-94-4 6253
7
Fludarabine Approved Phase 4,Phase 3,Phase 1,Phase 2 21679-14-1, 75607-67-9 30751
8
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
9
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 24356-66-9 21704 32326
10
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
11
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
12
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
13
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 171228-49-2 147912
14 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
15 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Antiparasitic Agents Phase 4,Phase 3,Phase 2
18 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
19 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
22 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
23 Hormones Phase 4,Phase 3,Phase 2,Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
25 Liposomal amphotericin B Phase 4,Phase 3,Phase 2
26 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
27 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
28 Echinocandins Phase 4,Phase 2,Phase 1
29 Alkylating Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1
31 Antimetabolites, Antineoplastic Phase 4,Phase 2,Phase 3,Phase 1
32 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
33 Antilymphocyte Serum Phase 4,Phase 3,Phase 2,Phase 1
34 Cyclosporins Phase 4,Phase 3,Phase 1,Phase 2
35 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Anti-HIV Agents Phase 4,Phase 2,Phase 1
37 Anti-Retroviral Agents Phase 4,Phase 2,Phase 1
38 JM 3100 Phase 4,Phase 2,Phase 1
39 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1
40
Voriconazole Approved, Investigational Phase 3 137234-62-9 71616
41
Oprelvekin Approved, Investigational Phase 2, Phase 3 145941-26-0
42
Azacitidine Approved, Investigational Phase 2, Phase 3, Phase 1 320-67-2 9444
43
Decitabine Approved, Investigational Phase 2, Phase 3, Phase 1 2353-33-5 451668
44
Clofarabine Approved, Investigational Phase 2, Phase 3, Phase 1 123318-82-1 119182
45
Etoposide Approved Phase 2, Phase 3, Phase 1 33419-42-0 36462
46
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 83-43-2 6741
47
Prednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 50-24-8 5755
48 Thiotepa Approved, Investigational Phase 3,Phase 2,Phase 1 52-24-4 5453
49
Asparaginase Approved, Investigational Phase 3,Phase 2 9015-68-3
50
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323

Interventional clinical trials:

(show top 50) (show all 448)

# Name Status NCT ID Phase Drugs
1 Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic Unknown status NCT00196768 Phase 4 Arsenic trioxide;Trisenox
2 PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia Completed NCT00362544 Phase 4 Ambisome
3 Optimized Radiological Diagnosis of Hepatic Candidiasis During the Treatment of Acute Leukemias Completed NCT01207843 Phase 4
4 Treatment of Relapsed Promyelocytic Leukemia With Arsenic Trioxide (ATO) Completed NCT00504764 Phase 4 Arsenic Trioxide;ATRA
5 Analysis of Data Collected in the European Group for Blood and Marrow Transplantation (EBMT) Registry for Off-Label Transplant Use of Plerixafor Completed NCT01362985 Phase 4
6 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Active, not recruiting NCT01200355 Phase 4 micafungin;posaconazole
7 Study of Busulfan and FLAG Conditioning Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation Not yet recruiting NCT02784561 Phase 4 Busulfan (Zhejiang Otsuka Pharmaceutical Co. Ltd);Cytarabine(Actavis Italy S.p.A);Fludarabine (Bayer);granulocyte colony-stimulating factor (KirinKunpeng);rabbit ATG(Sanofi/Genzyme)
8 A Optimal Anti-Thymoglobuline (ATG) Dose Decrease cGVHD But Not Increase Leukemia Relapse for Haplo-HSCT Not yet recruiting NCT03190733 Phase 4 ATG
9 Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT) Not yet recruiting NCT01339988 Phase 4 Busulfan/Cyclophosphamide
10 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
11 Antifungal Prophylaxis in Pediatric Acute Leukemia Unknown status NCT00624143 Phase 3 ORAL VORICONAZOLE and IV Amphotericin B
12 A Study Comparing Single Versus Double Umbilical Cord Blood Transplantation in the Young With Acute Leukemia Remission Unknown status NCT01067300 Phase 3
13 Megakaryocytic Progenitor Cells for Prophylaxis and Treatment of Thrombocytopenia Unknown status NCT02241031 Phase 2, Phase 3 thrombopoietin (TPO) and interleukin-11
14 Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Unknown status NCT01809392 Phase 2, Phase 3 decitabine
15 Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Unknown status NCT01800643 Phase 2, Phase 3
16 Thymoglobulin in Unrelated Hematopoietic Progenitor Cell Transplantation Unknown status NCT01217723 Phase 3
17 Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children Completed NCT01385891 Phase 2, Phase 3 Clofarabine VP 16 ciclophospahamide
18 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed NCT01371656 Phase 3 levofloxacin
19 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia Completed NCT00678275 Phase 3 ATG FRESENIUS (Anti-Lymphocyte-Globulin);ATG FRESENIUS (Anti-Lymphocyte-Globulin)
20 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
21 Peripheral Blood (PB) Versus Bone Marrow (BM) in Allogeneic Stem Cell Transplantation Completed NCT01020175 Phase 3
22 Busulfan Plus Cyclophosphamide vs Fludarabine as a Conditioning Regimen Completed NCT00774280 Phase 3 BuCy vs BuFlu
23 Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia Completed NCT00002700 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
24 Treatment of Acute Myeloid Leukemia (AML) in Adults 50 to 70 Years, Study of Two Anthracyclines and the Interest of Maintenance Treatment With Interleukin 2 Completed NCT00931138 Phase 3 chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin);chemotherapy (Aracytine + Daunorubicin)
25 A Randomized Study of Gemtuzumab Ozogamicin (GO) With Daunorubicine and Cytarabine in Untreated Acute Myeloid Leukemia (AML) Aged of 50-70 Years Old Completed NCT00927498 Phase 3 conventional chemotherapy (AraC + Daunorubicin),;Mylotarg associated with conventional chemotherapy (AraC + Daunorubicin),
26 Effect of Priming During Induction and Consolidations in Younger Acute Myeloid Leukemia (AML) Completed NCT00880243 Phase 3 GM-CSF
27 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
28 Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML) Completed NCT00093990 Phase 3 Tipifarnib;Zarnestra; R115777
29 Timed-Sequential Induction in CBF-AML Completed NCT00428558 Phase 3 Chemotherapy (DAUNORUBICINE-CYTARABINE);Chemotherapy (DAUNORUBICINE-CYTARABINE)
30 Efficacy/Safety of Frontline Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
31 Prevention of Left Ventricular Dysfunction During Chemotherapy Completed NCT01110824 Phase 3 Enalapril and carvedilol
32 TK008: Efficacy Study on the Strategy of HSV-Tk Engineering Donor Lymphocytes to Treat Patients With High Risk Acute Leukemia Recruiting NCT00914628 Phase 3
33 Comparing Two Diets in Patients Undergoing HSCT or Remission Induction Chemo for Acute Leukemia and MDS (UF-BMT-LDND-101) Recruiting NCT03016130 Phase 3
34 Transfusion Strategy in Hematological Intensive Care Unit Recruiting NCT02461264 Phase 3 Single red blood packed cells Transfusion;Two packed red blood cells Transfusion
35 Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301) Recruiting NCT02345850 Phase 3 Cyclophosphamide;Tacrolimus;Methotrexate
36 MRD-directed Donor Lymphocyte Infusion for Reduce of Relapse After Allo-HSCT Recruiting NCT02673008 Phase 2, Phase 3
37 Transplantation of Ex Vivo Expanded, UCB-derived, Stem & Progenitor Cells vs. Unmanipulated UCB for HM Patients Recruiting NCT02730299 Phase 3 NiCord®
38 Study of REVLIMID (Lenalidomide) Versus Placebo in Patients With Low Risk Myelodysplastic Syndrome Recruiting NCT01243476 Phase 3 Lenalidomide
39 Intergroup Randomized Trial for Children or Adolescents With B-Cell Non Hodgkin Lymphoma or B-Acute Leukemia: Rituximab Evaluation in High Risk Patients Active, not recruiting NCT01516580 Phase 3 Vincristine, cyclophosphamide, methotrexate, doxorubicin, cytarabine, ara-C;Rituximab, Vincristine, cyclophosphamide, methotrexate, doxorubicin, cytarabine, ara-C
40 Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
41 Nonmyeloablative Preparative Regimen Using Mylotarg for Patients With High Risk Acute Myeloid Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myeloid Leukemia (CML) and Myelodysplastic Syndrome (MDS) Terminated NCT00038805 Phase 2, Phase 3 Mylotarg
42 A Randomized Study of Post-Remission Therapy in Elderly Patients With Acute Myelogenous Leukemia. Terminated NCT00363025 Phase 3 Idarubicin versus daunorubicin
43 Stem Cell Transplantation for Hematological Malignancies Terminated NCT00176839 Phase 2, Phase 3 Busulfan;Cyclophosphamide;Melphalan;G-CSF;ATG
44 Vadastuximab Talirine (SGN-CD33A; 33A) Combined With Azacitidine or Decitabine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Terminated NCT02785900 Phase 3 33A;placebo;azacitidine;decitabine
45 HCT Versus CT in Elderly AML Terminated NCT00766779 Phase 3 Non-Transplant treatment approach for consolidation
46 Intensive Glycemic Control on Infectious Morbidity In Patients With Acute Leukemia Withdrawn NCT00943709 Phase 3 therapeutic insulin
47 ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML) Withdrawn NCT01067274 Phase 3 Vesanoid (ATRA);AZACITIDINE (VIDAZA);CYTARABINE
48 Pilot Study of Hematopoietic Stem Cell Transplantation From Two Matched Sibling Donors in Treating Patients With Poor Prognosis Acute Leukemia and Advanced Lymphoproliferative Malignancies Unknown status NCT01385072 Phase 1, Phase 2
49 Micafungin Prophylaxis During 1st Induction Chemotherapy for De Novo Acute Leukemia Unknown status NCT02440178 Phase 2 Micafungin
50 Clinical Study of DC Plus CIK for Patients With Relapse Acute Leukemia After Allo-HSCT Unknown status NCT01956630 Phase 1, Phase 2

Search NIH Clinical Center for Acute Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:
Promostem

Genetic Tests for Acute Leukemia

Genetic tests related to Acute Leukemia:

# Genetic test Affiliating Genes
1 Acute Leukemia 28

Anatomical Context for Acute Leukemia

MalaCards organs/tissues related to Acute Leukemia:

38
Myeloid, Bone, Bone Marrow, T Cells, B Cells, Nk Cells, Lung

Publications for Acute Leukemia

Articles related to Acute Leukemia:

(show top 50) (show all 1665)
# Title Authors Year
1
Chronic disseminated candidiasis and acute leukemia: Impact on survival and hematopoietic stem cell transplantation agenda. ( 29307444 )
2018
2
Targeting the bone marrow microenvironment in acute leukemia. ( 29431560 )
2018
3
Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma. ( 29416774 )
2018
4
Diagnostic Dilemma in Ambiguous Lineage Acute Leukemia: A Case Report. ( 29398827 )
2018
5
A protocol to isolate and qualify purified human preantral follicles in cases of acute leukemia, for future clinical applications. ( 29304838 )
2018
6
Surface endoglin (CD105) expression on acute leukemia blast cells: an extensive flow cytometry study of 1002 patients. ( 29334284 )
2018
7
Moxifloxacin versus levofloxacin for antibacterial prophylaxis in acute leukemia patients. ( 29310512 )
2018
8
Comparable survival using a CMV-matched or a mismatched donor for CMV+ patients undergoing T-replete haplo-HSCT with PT-Cy for acute leukemia: a study of behalf of the infectious diseases and acute leukemia working parties of the EBMT. ( 29330396 )
2018
9
Mometasone furoate inhibits growth of acute leukemia cells in childhood by regulating PI3K signaling pathway. ( 29421985 )
2018
10
Stodtmeister Cells (Polymorphs with Pelger-HuA<t Anomaly) Showing "Faggots" in Mixed Phenotypic Acute Leukemia (T/Myeloid). ( 29398816 )
2018
11
Secondary Acute Leukemia in Sarcoma Patients: A Population-Based Study. ( 29413281 )
2018
12
Impact of antithymocyte globulin doses in reduced intensity conditioning before allogeneic transplantation from matched sibling donor for patients with acute myeloid leukemia: a report from the acute leukemia working party of European group of Bone Marrow Transplantation. ( 29330391 )
2018
13
Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia. ( 29346763 )
2018
14
Hyperleukocytosis in infant acute leukemia: a role for manual exchange transfusion for leukoreduction. ( 29399859 )
2018
15
Acute bilateral retina hemorrhages beneath internal limiting membrane: An unusual ophthalmological case report of acute leukemia during complete clinical remission. ( 29443727 )
2018
16
Salvaged allogeneic hematopoietic stem cell transplantation for pediatric chemotherapy refractory acute leukemia. ( 29423036 )
2018
17
Maternal Exposure to Pesticides, Paternal Occupation in the Army/Police Force, and CYP2D6*4 Polymorphism in the Etiology of Childhood Acute Leukemia. ( 29432309 )
2018
18
Secondary Philadelphia chromosome acquired during therapy of acute leukemia and myelodysplastic syndrome. ( 29449681 )
2018
19
Leukemic phase of hepatosplenic T-cell lymphoma: A great masquerader of acute leukemia. ( 28937394 )
2017
20
Thrombosis in adult patients with acute leukemia. ( 28841588 )
2017
21
A Case of Therapy-Related Acute Leukemia With Mixed Phenotype With BCR-ABL1 After Treatment of Diffuse Large B-Cell Lymphoma. ( 28029006 )
2017
22
Plasma cell neoplasm with plasmablastic morphology mimicking acute leukemia. ( 28057674 )
2017
23
Effect of donor STAT4 polymorphism rs7574865 on clinical outcomes of pediatric acute leukemia patients after hematopoietic stem cell transplant. ( 27960128 )
2017
24
Spontaneous Fracture and Migration of a Totally Implanted Port Device to Pulmonary Artery in Acute Leukemia Child. ( 28060112 )
2017
25
Determinants of 1-year survival in critically ill acute leukemia patients: a GRRR-OH study. ( 28901791 )
2017
26
TACL'ing supportive care needs in pediatric early phase clinical trials for acute leukemia: A report from the therapeutic advances in childhood leukemia & lymphoma (TACL) consortium supportive care committee. ( 29190169 )
2017
27
Acute leukemia masquerading as xanthogranulomatous pyelonephritis. ( 28479773 )
2017
28
HLA-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients. ( 28883078 )
2017
29
A childhood-onset intestinal toxemia botulism during chemotherapy for relapsed acute leukemia. ( 28923072 )
2017
30
An Unlikely Rapid Transformation of Myelodysplastic Syndrome to Acute Leukemia: A Case Report. ( 28488979 )
2017
31
Increased Mortality Among Patients With Acute Leukemia Admitted on Weekends Compared to Weekdays. ( 28864171 )
2017
32
Melanization of Fusarium keratoplasticum (F. solani Species Complex) During Disseminated Fusariosis in a Patient with Acute Leukemia. ( 28616680 )
2017
33
How to effectively treat acute leukemia patients bearing MLL-rearrangements ? ( 28943239 )
2017
34
Second Neoplasms in Children Following a Treatment for Acute Leukemia and/or Lymphoma: 29 Years of Experience in a Single Institution in Argentina. ( 28945661 )
2017
35
Typhlitis (neutropenic enterocolitis) in patients with acute leukemia: a review. ( 28075196 )
2017
36
Haploidentical hematopoietic cell transplantation for adult acute myeloid leukemia: A position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. ( 28883081 )
2017
37
Ecthyma gangrenosum as first manifestation of acute leukemia. ( 28736062 )
2017
38
FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia. ( 28143883 )
2017
39
Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group. ( 29190164 )
2017
40
Reconstitution of multifunctional CD56(low)CD16(low) natural killer cell subset in children with acute leukemia given I+/I^ T cell-depleted HLA-haploidentical haematopoietic stem cell transplantation. ( 28932646 )
2017
41
Risk of sinusoidal obstruction syndrome in allogeneic stem cell transplantation after prior gemtuzumab ozogamicin treatment: a retrospective study from the Acute Leukemia Working Party of the EBMT. ( 28092357 )
2017
42
Small Cell Carcinoma Mimicking Acute Leukemia. ( 28794375 )
2017
43
Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia. ( 28900606 )
2017
44
T-cell transcription factor GATA-3 is an immunophenotypic marker of acute leukemias with T-cell differentiation. ( 28551327 )
2017
45
Acute Leukemia Patients' Needs: Qualitative Findings and Opportunities for Early Palliative Care. ( 28935132 )
2017
46
Risk factors in patients undergoing haploidentical hematopoietic stem cell transplantation for high-risk childhood acute leukemia. ( 28825215 )
2017
47
Impact of the ICAL on the treatment of acute leukemia. ( 29296969 )
2017
48
Establishment of cell line with NK/NKT phenotype from myeloid NK cell acute leukemia. ( 28934678 )
2017
49
Postinduction Minimal Residual Disease Predicts Outcome and Benefit From Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia With NPM1 Mutation: A Study by the Acute Leukemia French Association Group. ( 28056203 )
2017
50
Therapy-related Acute Leukemia With Mixed Phenotype and Novel t(1: 6)(q25;p23) After Treatment for High-risk Neuroblastoma. ( 28902076 )
2017

Variations for Acute Leukemia

Expression for Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Pathways for Acute Leukemia

GO Terms for Acute Leukemia

Cellular components related to Acute Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 AFF1 ANPEP BAALC CEBPA CREBBP DNTT

Biological processes related to Acute Leukemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.99 ANPEP ETV6 FLT3 JAK2 PAX5 STMN1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.92 CEBPA CREBBP CSF3 ETV6 KMT2A PAX5
3 transcription by RNA polymerase II GO:0006366 9.85 CEBPA ETV6 KMT2A PAX5 RUNX1 WT1
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 FLT3 JAK2 KIT
5 hemopoiesis GO:0030097 9.56 CD34 FLT3 KIT RUNX1
6 macrophage differentiation GO:0030225 9.54 CEBPA CSF3
7 embryonic hemopoiesis GO:0035162 9.52 KIT KMT2A
8 regulation of myeloid cell differentiation GO:0045637 9.49 CREBBP RUNX1
9 regulation of B cell receptor signaling pathway GO:0050855 9.48 PAX5 RUNX1
10 granulocyte differentiation GO:0030851 9.46 CEBPA CSF3
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.46 CSF3 FLT3 JAK2 KIT
12 myeloid progenitor cell differentiation GO:0002318 9.4 FLT3 KIT
13 hematopoietic stem cell proliferation GO:0071425 9.13 CD34 ETV6 RUNX1
14 cytokine-mediated signaling pathway GO:0019221 9.02 CEBPA CSF3 FLT3 JAK2 KIT

Molecular functions related to Acute Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.46 CEBPA ETV6 PAX5 WT1
2 transcription regulatory region DNA binding GO:0044212 9.26 CEBPA KMT2A RUNX1 WT1
3 DNA binding transcription factor activity GO:0003700 9.23 AFF1 CEBPA CREBBP ETV6 KMT2A PAX5

Sources for Acute Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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