MCID: ACT073
MIFTS: 62

Acute Leukemia malady

Summaries for Acute Leukemia

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. these lymphocytes (acute lymphocytic leukemia [all]) or myeloid cells (acute myelocytic leukemia [aml]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia. because they are bloodborne, they can infiltrate various organs and sites, including the liver, spleen, lymph nodes, cns, kidneys, and gonads.

MalaCards: Acute Leukemia, also known as stem cell leukemia, is related to myelodysplastic syndromes and acute myeloid leukemia, adult. An important gene associated with Acute Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are Transcriptional misregulation in cancer and Hematopoietic cell lineage. The compounds retinoic acid and etoposide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:64 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

Description from OMIM:47 308960

Aliases & Classifications for Acute Leukemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 47OMIM
See all sources

Aliases & Descriptions:

acute leukemia 8 10 45 31
stem cell leukemia 8 10
acute undifferentiated leukemia 61
stem cell leukaemia 8


External Ids:

Disease Ontology8 DOID:12603
ICD9CM27 208.0
NCIt40 C9298, C9300
OMIM47 308960

Related Diseases for Acute Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1myelodysplastic syndromes30.6WT1, FLT3, MPO, DNTT, CDKN2B, HOXA9
2acute myeloid leukemia, adult30.5WT1, FLT3, CDKN2B
3refractory anemia30.4WT1, FLT3, CDKN2B
4chronic myeloid leukemia30.4WT1, FOXO3, FLT3, MPO, PRAME, DNTT
5acute promyelocytic leukemia30.3FLT3, MPO, DNTT
6acute lymphocytic leukemia30.3WT1, TCF3, TAL1, IL3RA, FLT3, MPO
7lymphoblastic lymphoma30.3MPO, DNTT, CDKN2B, CD7, TAL1
8acute myelomonocytic leukemia30.3MPO, DNTT
9acute lymphoblastic leukemia, childhood30.2FLT3, MTHFR, DNTT, CDKN2B
10megakaryocytic leukemia30.2MKL1, MPO
11acute monocytic leukemia30.0MPO
12myeloid sarcoma30.0MPO
13down syndrome29.8MTHFR, FLT3
14thyroid cancer29.8FLT3
15leukemia, acute nonlymphocytic29.8DNTT, CD7
16acute t cell leukemia11.0
17t-cell leukemia11.0
18acute myeloid leukemia10.8
19hematopoietic stem cell transplantation10.6
20acute biphenotypic leukemia10.6
21lymphoid leukemia10.4
22natural killer cell leukemia10.4
23wilms tumor10.4
24leukemia, acute pre-b-cell10.4
25aspergillosis10.4
26granulocytopenia10.4
27adult t-cell leukemia10.3
28invasive aspergillosis10.3
29graft versus host disease10.3
30acute graft versus host disease10.3
31plasma cell leukemia10.2
32pediatric t-cell leukemia10.2
33central nervous system leukemia10.2
34n syndrome10.2
35tetraploidy10.2
36leukemia, post-chemotherapy10.2
37bilineal acute leukemia10.2
38thymoma10.1
39glucocorticoid resistance10.1
40alveolar rhabdomyosarcoma10.1
41adult lymphoma10.1
42pernicious anemia10.1
43oral candidiasis10.1
44thrombocytopenia10.1
45acute erythroid leukemia10.1
46chronic myelomonocytic leukemia10.1
47myeloproliferative disorder10.1
48leukopenia10.1
49acute undifferentiated leukemia10.1
50priapism10.1

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to acute leukemia

Clinical Features for Acute Leukemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

308960

Drugs & Therapeutics for Acute Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Leukemia

Search NIH Clinical Center for Acute Leukemia

Search CenterWatch for Acute Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:
Promostem

Genetic Tests for Acute Leukemia

Anatomical Context for Acute Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acute Leukemia:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Uterus, Bone marrow, Whole blood, Thymus, Cerebellum, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Placenta, Prostate, Testis, Cervix, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Temporal lobe, Fetal liver, Fetal lung, Bronchial epithelium, Fetal thyroid, Pineal, Pituitary, Testis germ

Animal Models for Acute Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.2DNTT, TCF3, FLT3, MPO, FOXO3, WT1
2MP:000538712.1MPO, WT1, FOXO3, FLT3, DNTT, CDKN2B
3MP:000538911.4FOXO3, MTHFR, CDKN2B, HOXA9, TCF3, ZNF384
4MP:000538411.4MKL1, TAL1, CD7, CDKN2B, DNTT, FLT3
5MP:001077111.1TAL1, HOXA9, CDKN2B, MKL1, TCF3

Publications for Acute Leukemia

Sources:
51PubMed
See all sources

Articles related to Acute Leukemia:

(show top 50)    (show all 10138)
idTitleAuthorsYear
1
Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia. (23929217)
2014
2
Childhood high-risk acute lymphoblastic leukemia in first remission: results after chemotherapy or transplant from the AIEOP ALL 2000 study. (24415536)
2014
3
Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. (24419525)
2014
4
High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol. (23911702)
2014
5
XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia. (23662987)
2013
6
The promoter of miR-663 is hypermethylated in Chinese pediatric acute myeloid leukemia (AML). (23870168)
2013
7
Acute promyelocytic leukemia; early diagnosis is the key to survival. (23702072)
2013
8
MicroRNA profiling in chemoresistant and chemosensitive acute myeloid leukemia. (23689423)
2013
9
A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation. (23483057)
2013
10
Case of the disappearing subdural hygromas in a pediatric patient with acute lymphocytic leukemia. (22957755)
2012
11
Specific small nucleolar RNA expression profiles in acute leukemia. (22522792)
2012
12
Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. (22291079)
2012
13
Pediatric T-cell acute lymphoblastic leukemia with transient pure red cell aplasia. (22294462)
2012
14
The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia. (20952516)
2011
15
Novel mutations of the nucleophosmin (NPM-1) gene in Egyptian patients with acute myeloid leukemia: a pilot study. (22099964)
2011
16
Pharmacologic expansion of donor-derived, naturally occurring CD4(+)Foxp3(+) regulatory T cells reduces acute graft-versus-host disease lethality without abrogating the graft-versus-leukemia effect in murine models. (21145405)
2011
17
Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy. (21685470)
2011
18
Novel targets for treatment of adult acute lymphocytic leukemia. (20680526)
2010
19
Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. (20212254)
2010
20
Higher incidence of relapse in patients with acute myelocytic leukemia infused with higher doses of CD34+ cells from leukapheresis products autografted during the first remission. (20479285)
2010
21
Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B. (19059939)
2009
22
Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1-S phase transition and passage through the S phase. (18668132)
2009
23
Diabetic ketoacidosis during therapy for pediatric acute lymphoblastic leukemia. (18266226)
2008
24
The evaluation of hTERT mRNA expression in acute leukemia children and 2 years follow-up of 40 cases. (18293058)
2008
25
Radiation-induced meningioma following prophylactic radiotherapy for acute lymphoblastic leukemia in childhood. (17190987)
2007
26
Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome. (17646667)
2007
27
Prevalence of FLT3 internal tandem duplication in adult acute myelogenous leukemia]. (18094582)
2007
28
TNF-alpha induces transient resistance to Fas-induced apoptosis in eosinophilic acute myeloid leukemia cells. (17349210)
2007
29
Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia. (17344919)
2007
30
Survivin and EPR-1 expression in acute leukemias: prognostic significance and review of the literature. (17328950)
2007
31
HOX deregulation in acute myeloid leukemia. (17404613)
2007
32
Rapid transformation of atypical myeloproliferative disorder with consistent t(8;13) to B-cell acute lymphoblastic leukemia: a case report. (17852454)
2007
33
In vivo expression of survivin and its splice variant survivin-2B: impact on clinical outcome in acute myeloid leukemia. (16619249)
2006
34
P-glycoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia. (15547738)
2004
35
Dynamic observation of vascular endothelial growth factor (VEGF)/VEGF-receptors expression in acute leukemia]. (15634546)
2004
36
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. (12750176)
2003
37
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). (12124344)
2002
38
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. (12114423)
2002
39
Study of tumor cells sensitivity in patients with acute leukemia to cytokines and their combined use with drugs in vitro by MTT analysis]. (10943155)
2000
40
A comparative pharmacokinetic study of doxorubicin and 4'-epi-doxorubicin in children with acute lymphocytic leukemia using a limited sampling procedure. (10789596)
2000
41
Familial neurofibromatosis type I and adult acute lymphocytic leukemia. (10329933)
1999
42
Biomarkers in long survivors of pediatric acute lymphoblastic leukemia patients: late effects of cancer chemotherapy. (9838123)
1998
43
A truncated isoform of the human beta chain common to the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 with increased mRNA expression in some patients with acute leukemia. (9414269)
1998
44
p190 BCR-ABL mRNA is expressed at low levels in p210-positive chronic myeloid and acute lymphoblastic leukemias. (8652835)
1996
45
Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia. (8721678)
1996
46
Terminal acute myelogenous leukemia in a patient with congenital agranulocytosis. (8342541)
1993
47
Monocytes appearing repeatedly after chemotherapies had an identical rearrangement pattern of immunoglobulin with leukemic blasts in a patient with CD13+ acute lymphoblastic leukemia. (1350159)
1992
48
Growth factor requirements of childhood acute T-lymphoblastic leukemia: correlation between presence of chromosomal abnormalities and ability to grow permanently in vitro. (1706955)
1991
49
Myeloblastic and lymphoblastic markers in acute undifferentiated leukemia and chronic myelogenous leukemia in blast crisis. (6937237)
1980
50
Acute myelomonocytic leukemia. (5265508)
1969

Genetic Variations for Acute Leukemia

Expression for genes affiliated with Acute Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Pathways for genes affiliated with Acute Leukemia

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Acute Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3TCF3, TAF15, HOXA9, MPO, FLT3, WT1
211.0CD7, IL3RA, FLT3, DNTT
310.9CDKN2B, TCF3, FOXO3
410.9CDKN2B, DNTT, FOXO3

Compounds for genes affiliated with Acute Leukemia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 11DrugBank
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Compounds related to Acute Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.8MXD1, WT1, FLT3, MPO, MTHFR, DNTT
2etoposide45 50 60 1114.3WT1, FOXO3, FLT3, DNTT, TAL1
3thymidine45 2412.3WT1, FLT3, MTHFR, DNTT, IL3RA
4carboplatin45 50 1113.0DNTT, MTHFR, MPO
5naphthol as-d chloroacetate4510.9DNTT, MPO
6oligonucleotide4510.9TAL1, DNTT, FLT3, FOXO3, WT1
7cytarabine45 50 1112.8FLT3, MPO, CDKN2B
8nitro4510.8MPO, WT1
9gemtuzumab ozogamicin45 1111.8FLT3, WT1

GO Terms for genes affiliated with Acute Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.2ZNF384, WT1, FOXO3, MPO, PRAME, BAALC
2nucleolusGO:00573011.4BAALC, MKL1, DNTT, TAF15, MXD1, ZNF384

Biological processes related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635111.8ZNF384, FOXO3, PRAME, MKL1, CDKN2B, HOXA7
2positive regulation of transcription from RNA polymerase II promoterGO:04594411.5ZNF384, TCF3, TAL1, HOXA7, CDKN2B, MKL1
3positive regulation of transcription, DNA-dependentGO:04589311.2WT1, FOXO3, TAL1, TAF15, TCF3
4positive regulation of erythrocyte differentiationGO:04564810.7FOXO3, TAL1
5megakaryocyte differentiationGO:03021910.7TAL1, CDKN2B
6definitive hemopoiesisGO:06021610.4TAL1, HOXA9

Molecular functions related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356511.3ZNF384, TCF3, HOXA9, HOXA7, FOXO3, WT1
2sequence-specific DNA binding transcription factor activityGO:00370011.3TCF3, WT1, FOXO3, MKL1, HOXA7, HOXA9

Products for genes affiliated with Acute Leukemia

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  • Antibodies

Sources for Acute Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet