Acute Leukemia malady

Disease Ontology: A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. these lymphocytes (acute lymphocytic leukemia [all]) or myeloid cells (acute myelocytic leukemia [aml]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia. because they are bloodborne, they can infiltrate various organs and sites, including the liver, spleen, lymph nodes, cns, kidneys, and gonads.⁶

MalaCards: Acute Leukemia, also known as acute undifferentiated leukemia, is related to leukemia and acute lymphoblastic leukemia. An important gene associated with Acute Leukemia is PRAME (preferentially expressed antigen in melanoma), and among its related pathways are Hematopoietic cell lineage and RAR-Gamma-RXR-Alpha Degradation. The compounds arginine and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are behavior/neurological and normal.

Wikipedia: Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original...⁴⁴ more...

Aliases & Descriptions:

acute leukemia 6 8 32 acute undifferentiated leukemia 43

Diseases related to acute leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 884)

id	Related Disease	Score	Top Affiliating Genes
1	leukemia	69.0	ZNF384, PICALM, SH3GL1, NCAM1, NCL, NCOA2
2	acute lymphoblastic leukemia	49.5	PICALM, KIT, KITLG, RB1, SELL, SERPINC1
3	myeloid leukemia	49.3	PICALM, NCAM1, NCL, NCOA2, NCOR1, NCOR2
4	carcinoma	48.5	ZNF384, NCAM1, NCL, NCOA2, NCOR1, NCOR2
5	lymphoblastic leukemia	47.7	ZNF384, PICALM, NCAM1, KIT, KITLG, VWF
6	myelodysplastic syndrome	43.4	KIT, KITLG, SELL, BMI1, RARA, RAN
7	chronic myeloid leukemia	41.0	KIT, KITLG, SELP, MYC, MYB, BMI1
8	non-hodgkin lymphoma	40.4	NCOR2, KITLG, SELL, NAT2, MYC, MYB
9	lymphocytic leukemia	37.7	NCAM1, NCL, KIT, KITLG, RB1, SELL
10	lung carcinoma	37.1	NCAM1, RB1, SELL, SERPINA3, NAT2, VEGFA
11	myeloma	37.0	NCAM1, NCOR2, KIT, KITLG, VWF, RB1
12	hodgkin's lymphoma	36.4	SELP, BMI1, RAG1, PAX5, BCL2, BCL2L1
13	hematopoiesis	35.4	REN, KIT, KITLG, RB1, VEGFA, LMO2
14	chronic lymphocytic leukemia	35.4	SELL, MYB, BIRC5, BIRC7, PAX5, BCL2
15	sarcoma	35.2	ZNF384, NCAM1, REN, KIT, KITLG, VWF
16	leukemia/lymphoma	34.6	KITLG, RB1, VEGFA, MYC, RAG1, PAX5
17	acute myeloid leukemia	34.5	PICALM, SH3GL1, KIT, LPP, CEBPA, MLLT10
18	t-cell leukemia	34.5	LMO2, MYC, MYB, RAG1, BIRC5, BCL2
19	acute biphenotypic leukemia	34.0	MPO, MLL, MLLT10, F3, F2, NOTCH1
20	adult t-cell leukemia	33.6	NCAM1, MYC, MYB, PAX5, BCL2, BCL2L1
21	acute promyelocytic leukemia	32.8	NCAM1, NCOR1, NCOR2, MYC, RARA, BCL2
22	wilms tumor	32.4	NCAM1, REN, VWF, VEGFA, MYC, MYB
23	childhood leukemia	32.2	NCOR1, BCL2, BCL2L1, MVP, BAX, MTHFR
24	multiple myeloma	31.7	NCAM1, BCL2L1, CD19, ITGA4, IL6, MCL1
25	down syndrome	31.7	RB1, SERPINA3, MYC, RARA, BCR, MTRR
26	lymphoblastic lymphoma	31.3	LMO2, RAG1, PAX5, MPO, CDKN2B, CD7
27	retinoblastoma	31.2	NCAM1, NCL, KIT, KITLG, RB1, VEGFA
28	leukemia, acute nonlymphocytic	31.2	MVP, CD33, CD34, CD7, FPGS, MLL
29	acute myelomonocytic leukemia	30.9	MPO, MLL, CBFB, ETV6, CREBBP, DNTT
30	megakaryoblastic leukemia	30.8	PICALM, KIT, KITLG, VWF, SELP, BMP6
31	graft versus host disease	30.8	SELL, IL11, IL2, IL2RB, IL3, IL4
32	stem cell leukemia	30.7	KIT, MPO, FLT3, TRD@, TAL1, RUNX1
33	breast cancer	30.7	NCOA2, RBP1, MYC, BMP6, UBC, CDK6
34	megakaryocytic leukemia	30.4	NCAM1, KITLG, VWF, BCL2, MPO, JAK2
35	thrombocytopenia	30.2	NCAM1, KITLG, VWF, SELL, SELP, SERPINC1
36	dna topoisomerase ii	30.2	MYC, BCL2L1, JUN, CDKN1A, CDK2, MLL
37	chronic myeloproliferative disease	30.0	VEGFA, LDHC, MTHFR, B2M, MPL, MPO
38	hypereosinophilic syndrome	30.0	KIT, JUN, JAK2, IL2, IL3, IFNA1
39	essential thrombocythemia	29.9	KIT, KITLG, VWF, SELP, BCL2L1, MPL
40	rhabdomyosarcoma	29.7	NCAM1, KITLG, RB1, VEGFA, MYC, BMP6
41	glucocorticoid resistance	29.6	NCOA2, REN, KDR, BCL2, XIAP, JUN
42	hemoglobinuria	29.6	VWF, SELL, SELP, MTHFR, CD58, CD59
43	synovial sarcoma	29.4	KIT, RARA, BCL2, MUC1, CDH1, MDM2
44	paroxysmal nocturnal hemoglobinuria	29.4	VWF, SELP, MTHFR, CD58, CD59, CD55
45	osteosarcoma	29.3	KIT, VWF, RB1, SERPINC1, VEGFA, MYC
46	thymoma	29.2	KIT, BCL2, MUC1, XIAP, B2M, MPO
47	neutropenia	29.2	KITLG, BIRC5, BCL2, LEF1, MPL, MPO
48	aspergillosis	29.0	CD79A, IL17A, IL1A, IL1B, IL1RN, IL4
49	leukopenia	29.0	NCAM1, SELL, SERPINC1, RAG1, MPO, CD79A
50	candidiasis	28.9	B2M, MPO, CD79A, CD86, CD40LG, CD9

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

MalaCards organs/tissues related to acute leukemia:

²²

MGI Mouse Phenotypes related to acute leukemia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	INF	NCAM1, NCOA2, NCOR1, NCOR2, REN, KIT
2	normal phenotype	MP:0002873	INF	REN, VEGFA, MYC, MYB, RAG1, RARA
3	homeostasis/metabolism phenotype	MP:0005376	INF	PICALM, NCOR1, NCOR2, REN, KIT, KITLG
4	cellular phenotype	MP:0005384	INF	PICALM, NCAM1, NCOR1, NCOR2, KIT, KITLG
5	craniofacial phenotype	MP:0005382	INF	NCOR2, KIT, KITLG, BMI1, , LEF1
6	nervous system phenotype	MP:0003631	INF	NCOR1, REN, KIT, KITLG, VWF, RB1
7	cardiovascular system phenotype	MP:0005385	INF	NCOR2, REN, KIT, KITLG, VWF, RB1
8	muscle phenotype	MP:0005369	INF	NCOR1, REN, KIT, RB1, VEGFA, MYC
9	digestive/alimentary phenotype	MP:0005381	INF	NCOR2, KIT, KITLG, VWF, RB1, VEGFA
10	skeleton phenotype	MP:0005390	INF	ZNF384, KIT, KITLG, RB1, VEGFA, MYC
11	liver/biliary system phenotype	MP:0005370	INF	PICALM, NCOR1, NCOR2, KIT, RBP1, SERPINC1
12	respiratory system phenotype	MP:0005388	12.4	SELL, SELP, SERPINB1, RAG1, BID, MN1
13	pigmentation phenotype	MP:0001186	9.9	KIT, KITLG, RB1, RBP1, SERPINC1, MYC
14	vision/eye phenotype	MP:0005391	8.8	NCAM1, KIT, KITLG, RB1, RBP1, SELP
15	reproductive system phenotype	MP:0005389	INF	ZNF384, NCOA2, REN, RBP1, VEGFA, RARA
16	growth/size phenotype	MP:0005378	INF	ZNF384, PICALM, NCOA2, NCOR1, NCOR2, REN
17	immune system phenotype	MP:0005387	INF	PICALM, NCOA2, NCOR1, REN, KIT, VWF
18	embryogenesis phenotype	MP:0005380	INF	PICALM, NCOA2, NCOR1, KIT, SERPINC1, LMO2
19	integument phenotype	MP:0010771	INF	NCOA2, NCOR1, KIT, KITLG, RB1, SELP
20	hematopoietic system phenotype	MP:0005397	INF	PICALM, KIT, RBP1, SERPINB1, LMO2, BMI1
21	renal/urinary system phenotype	MP:0005367	INF	REN, KIT, SELP, LMO2, RAG1, RARA
22	hearing/vestibular/ear phenotype	MP:0005377	INF	KIT, KITLG, RB1, RBP1, MYC, RAG1
23	no phenotypic analysis	MP:0003012	INF	NCOA2, RB1, VEGFA, MYC, LDHC, MUC1
24	tumorigenesis	MP:0002006	INF	KIT, KITLG, RB1, SELL, LMO2, MYC
25	limbs/digits/tail phenotype	MP:0005371	INF	KIT, KITLG, RB1, VEGFA, BMI1, RARA
26	endocrine/exocrine gland phenotype	MP:0005379	INF	ZNF384, NCOA2, SELL, KDM5A, LDHC, CDK6
27	adipose tissue phenotype	MP:0005375	INF	NCOR1, NCOR2, RB1, MYC, BCL2, LEF1
28	mortality/aging	MP:0010768	INF	PICALM, NCAM1, NCOR1, NCOR2, REN, KITLG
29	other phenotype	MP:0005395	INF	RARA, , KDR, JAK2, CDKN2A, CD40LG

Articles related to acute leukemia:

(show top 50)    (show all 753)

id	Title	Authors	Year	Affiliating Genes
1	Association of single nucleotide polymorphism of red uced folate carrier gene with susceptibility to acute leukemia]. (21811990)	Zhao W.... Chen X.W.	2011	SLC19A1
2	Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress. (21072047)	Blalock W.L.... Cocco L.	2011	EIF2AK2
3	Elevated mRNA level of hST6Gal I and hST3Gal V positi vely correlates with the high risk of pediatric acute leukemia. (19709745)	Mondal S.... Mandal C.	2010	ST6GAL1, ST3GAL5
4	Wilms' tumor gene 1 expression analysis by real-time quantitative polymerase chain reaction for monitoring of minimal residual disea se in acute leukemia. (19811333)	Nowakowska-Kopera A.... Skotnicki A.B.	2009	WT1
5	Mature B-cell lymphoblastic leukemia with MLL rearrangement: an uncommon and distinct subset of childhood acute leukemia. (18007578)	Blin N.... Avet-Loiseau H.	2008	MLL
6	ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations. (18281529)	Strehl S.... Izraeli S.	2008	NOTCH1, NCOA2, ETV6
7	WT1 protein expression in childhood acute leukemia. (18161786)	Kerst G.... MA1ller I.	2008	WT1
8	Catalase activity and arsenic sensitivity in acute leukemia. (18949620)	Coe E.... Schimmer A.D.	2008	CAT
9	FLT3 as a therapeutic target in childhood acute leukemia. (17584026)	Stubbs M.C.... Armstrong S.A.	2007	FLT3
10	Expression of vascular endothelial growth factor receptor 3 and Tie1 tyrosine kinase receptor on acute leukemia cells. (16685739)	Kivivuori S.M.... Saarinen-Pihkala U.	2007	FLT4, TIE1
11	Changes of serum thymidine kinase in children with acute leukemia. (17649797)	Votava T.... Kormunda S.	2007	TKT
12	Single-nucleotide polymorphisms of the cytidine deaminase gene in childhood with acute leukemia and normal Chinese children (18067088)	Yue L.J.... Zhang M.	2007	CDA
13	The MLL recombinome of acute leukemias. (16511515)	Meyer C.... Marschalek R.	2006	MLL, SETD7, MLLT3
14	Molecular cytogenetic findings of acute leukemia included in the Brazilian Collaborative Study Group of Infant acute leukemia. (16261608)	Emerenciano M.... Pombo-de-Oliveira M.S.	2006	MLL
15	Risk score model for fatal intracranial hemorrhage in acute leukemia. (16525500)	Kim H.... Lee K.H.	2006	F2
16	The expression of iASPP in acute leukemias. (15607367)	Zhang X.... Wang J.	2005	PPP1R13L
17	Study on platelet activated state and platelet activated function in adults with acute leukemia (15972140)	Luo W.D.... Guo Q.Y.	2005	SELP
18	Low-dose cytosine arabinoside (LD-AraC) vs LD-AraC plus granulocyte/macrophage colony stimulating factor vs LD-AraC plus Interleukin-3 for myelodysplastic syndrome patients with a high risk of developing acute leukemia: final results of a randomized phase III study (06903) of the EORTC Leukemia Cooperative Group. (16151466)	Zwierzina H.... Amadori S.	2005	IL3
19	Detection of glutathione S-transferase and lung resistance-related proteins in acute leukemia and its clinical significance (16045016)	Zhang Z.M.... Huang C.H.	2005	MVP
20	Methylation silencing of the Apaf-1 gene in acute leukemia. (15972851)	Furukawa Y.... Furukawa Y.	2005	DNMT1, APAF1
21	Mutation analysis of SHIP gene in acute leukemia. (15363123)	Luo J.M.... Ohno R.	2004	INPP5D
22	The expression of CD19 in 210 cases of childhood acute leukemia and its significance (15144712)	Chen Y.H.... Ning B.T.	2004	CD19
23	Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. (14691124)	RingdAcn O.... Frassoni F.	2004	CSF3
24	Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. (14726393)	Santos S.C.... Dias S.	2004	KDR, VEGFA
25	PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia. (15492262)	Tiacci E.... Falini B.	2004	PAX5, CD79A
26	Study on efficacy of treatment of acute leukemia by shengfu injection in combination with chemotherapy and the effect on cellular immunity, serum interleukin-6 and tumor necrosis factor-alpha levels (12764905)	Wei Y.F.... Wang S.Y.	2003	CD8A
27	An unusual case of CD4+ CD7+ CD56+ acute leukemia with overlapping features of type 2 dendritic cell (DC2) and myeloid/NK cell precursor acute leukemia. (12950240)	Anargyrou K.... Vaiopoulos G.	2003	IL3RA
28	MLL AT-hook sequence is strongly conserved in infant acute leukemia with or without MLL gene rearrangement. (12835743)	Macrini C.M.... Alves G.	2003	MLL
29	Peripheral blood stem cell collection in children wit h acute leukemia: effectiveness of the 'DIAVE' mobilizing regimen. (12368951)	Balduzzi A.... Uderzo C.	2002	CSF3
30	Loss of heterozygosity and microsatellite instability at the MLL locus are common in childhood acute leukemia, but not in infant acute leukemia. (10381524)	Webb J.C.... Brickell P.M.	1999	MLL
31	Study of thrombopoietin and its receptor C-mpl in acute leukemia (11601235)	Guo Y.... Luo M.	1999	THPO, MPL
32	Study on the expression of interleukin-8 and its receptors in acute leukemia (11498839)	Liu J.... Zhang Y.	1999	CXCR1
33	MDR1/P-GP expression as a prognostic factor in acute leukemias. (10500774)	Marie J.P.... Legrand O.	1999	ABCB1
34	Transient increase in blasts mimicking acute leukemia and progressing myelodysplasia in patients receiving growth factor. (9620023)	Meyerson H.J.... Rosenthal N.S.	1998	CSF2, CSF3
35	Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias. (9230194)	Cimino G.... Greaves M.	1997	MLL
36	Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias. (9407735)	Sperling C.... Ludwig W.D.	1997	KIT
37	Clinical importance of interleukin-2 receptor alpha-chain expression in acute leukemia. The Japan Cooperative Group of Leukemia/Lymphoma. (9167045)	Nakase K.... Uchino H.	1997	IL2
38	Flow cytometric analysis of Thy-1 expression in CD34-positive acute leukemia. (9401277)	Inaba T.... Nakagawa M.	1997	THY1
39	Biological characteristics of CD7(+) acute leukemia. (8726405)	Miwa H.... Kita K.	1996	ABCB1
40	G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation of resistant or relapsing acute leukemias. (8656684)	Rambaldi A.... Barbui T.	1996	CSF3
41	Natural killer cell acute leukemia with myeloid antigen expression. A previously undescribed form of acute leukemia. (7639197)	Dunphy C.H.... Rodriguez G.	1995	DNTT
42	The therapeutic significance of myeloperoxidase detectable only by electron microscopy in acute leukemia. (8035623)	Koike T.... Shibata A.	1994	MPO
43	HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer c ell acute leukemia: a previously unrecognized form of acute leukemia potentiall y misdiagnosed as French-American-British acute myeloid leukemia-M3. (7517211)	Scott A.A.... Licht J.D.	1994	RARA, MPO
44	Mechanisms of p53 alteration in acute leukemias. (7523798)	Schottelius A.... LA1bbert M.	1994	MDM2, TP53
45	Clonogenic cells of acute leukemia secondary to myeloproliferative and myelodysplastic syndromes (7754436)	Almeida J.... San Miguel J.F.	1994	CD19
46	Granulocyte colony-stimulating factor receptors on human acute leukemia: biphenotypic leukemic cells possess granulocyte colony-stimulating factor receptors. (1534271)	Shimoda K.... Okamura T.	1992	CSF3, CSF3R
47	Circulating transferrin receptor in acute leukemias. (1421178)	Kato J.... Miyazaki E.	1992	TFRC
48	Trisomy 13: a new recurring chromosome abnormality in acute leukemia. (1698482)	DAPhner H.... Testa J.R.	1990	DNTT
49	Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia. (1697646)	Ohno R.... Sakai Y.	1990	CSF2, CSF3
50	The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias. (2799390)	Mellentin J.D.... Cleary M.L.	1989	TCF3

Genes related to acute leukemia according to GeneCards:

(show top 50)    (show all 450)

id	Symbol	Description	Score	GeneCards Section Context
1	PRAME	preferentially expressed antigen in melanoma	11.0	Summaries, Publications
2	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications, UniProt Related, Summaries
3	ZNF384	zinc finger protein 384	11.0	Summaries, Publications
4	TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	11.0	Publications, Summaries
5	MXD1	MAX dimerization protein 1	11.0	Summaries
6	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	11.0	Publications, Summaries
7	FOXO3	forkhead box O3	11.0	Summaries
8	BAALC	brain and acute leukemia, cytoplasmic	11.0	Proteins, Publications, Expressions, Orthologs (show all 6 sections) Aliases & Descriptions, Transcripts
9	MKL1	megakaryoblastic leukemia (translocation) 1	11.0	Aliases & Descriptions
10	WBP1L	WW domain binding protein 1-like	11.0	Publications, Aliases & Descriptions
11	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
12	LYL1	lymphoblastic leukemia derived sequence 1	11.0	Publications
13	ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	11.0	Publications
14	HOXA7	homeobox A7	11.0	Publications
15	HOXA9	homeobox A9	11.0	Publications
16	CD7	CD7 molecule	11.0	Publications
17	TRD@	T cell receptor delta locus	11.0	Publications
18	THY1	Thy-1 cell surface antigen	11.0	Publications
19	LBX1	ladybird homeobox 1	11.0	Publications
20	IL3RA	interleukin 3 receptor, alpha (low affinity)	11.0	Publications
21	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
22	C19orf48	chromosome 19 open reading frame 48	11.0	Publications
23	MNX1	motor neuron and pancreas homeobox 1	11.0	Publications
24	FOXO4	forkhead box O4	11.0	Publications
25	MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	11.0	Publications
26	TAL1	T-cell acute lymphocytic leukemia 1	11.0	Publications
27	WT1	Wilms tumor 1	11.0	Publications, Functions
28	CSN2	casein beta	11.0	Publications
29	CDA	cytidine deaminase	11.0	Publications
30	CD22	CD22 molecule	11.0	Publications
31	CD33	CD33 molecule	11.0	Publications
32	FPGS	folylpolyglutamate synthase	11.0	Publications
33	MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	11.0	Orthologs, Publications
34	GATA2	GATA binding protein 2	11.0	Publications
35	FLT3	fms-related tyrosine kinase 3	11.0	Publications
36	CD8A	CD8a molecule	11.0	Publications
37	CD34	CD34 molecule	11.0	Publications
38	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
39	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	11.0	Publications
40	THPO	thrombopoietin	11.0	Publications
41	STMN1	stathmin 1	11.0	Publications, Expressions
42	SLC29A1	solute carrier family 29 (nucleoside transporters), member 1	11.0	Publications
43	AFF1	AF4/FMR2 family, member 1	11.0	Publications
44	MVP	major vault protein	11.0	Publications
45	TPMT	thiopurine S-methyltransferase	11.0	Publications
46	MPO	myeloperoxidase	11.0	Publications
47	TERF1	telomeric repeat binding factor (NIMA-interacting) 1	11.0	Publications
48	CD84	CD84 molecule	11.0	Publications
49	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
50	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications

Pathways related to acute leukemia according to GeneDecks:

(show top 50)    (show all 256)

id	Pathway	Score	Top Affiliating Genes
1	Hematopoietic cell lineage20	12.3	KIT, KITLG, CD33, CD8A, CD59, CD34
2	RAR-Gamma-RXR-Alpha Degradation36	12.0	UBC, CD80, IL11, IL16, IL2, IL21
3	Jak-STAT signaling pathway20	11.8	MYC, BCL2L1, MPL, JAK1, JAK2, IL11
4	p38 Signaling36	11.6	KIT, KITLG, BMP6, KDR, BCL2, BAX
5	Development_Thrombopoetin signaling via JAK-STAT pathway41	11.3	SERPINA3, BCL2L1, MPL, JAK2, CDKN1A, CDKN1B
6	IL-6 Pathway36	11.2	BMP6, BAX, CD80, IL11, IL16, IL3
7	Cell Cycle / Checkpoint Control3	11.2	PCM1, RB1, XRCC1, AURKB, MSH2, ATM
8	JNK Pathway36	11.2	KIT, KITLG, BMP6, KDR, BCL2, BAX
9	STAT3 Pathway36	11.1	MYC, BMP6, BCL2, BAX, JAK2, CDKN1A
10	Signal transduction AKT signaling10	10.9	HSP90AB1
11	Apoptosis20	10.9	BID, BCL2, BCL2L1, BAD, BAX, XIAP
12	Development Thrombopoetin signaling via JAK-STAT pathway10	10.9	SERPINA3, BCL2L1, MPL, JAK2, CDKN1A, CDKN1B
13	PGC1Alpha Pathway36	10.9	BMP6, BCL2, BAX, CD80, IL11, IL16
14	TNF Superfamily Pathway36	10.8	JUN, MAPK8, MAPK10, CASP3, CASP1, CASP2
15	Glucocorticoid Receptor Signaling36	10.7	NCOR1, NCOR2, BMP6, BCL2, BAX, CEBPA
16	Apoptosis and survival FAS signaling cascades10	10.6	BID, BCL2, BAX, XIAP, CFLAR, APAF1
17	Telomerase Components in Cell Signaling36	10.6	KIT, KITLG, RB1, MYC, BMP6, KDR
18	Colorectal cancer20	10.6	LEF1, BAD, MSH2, MSH3, MAPK8, CASP9
19	PEDF Induced Signaling36	10.6	BMP6, BCL2, BCL2L1, BAX, CFLAR, CD80
20	Apoptosis and survival_Apoptotic TNF-family pathways41	10.6	BID, BCL2, BCL2L1, BAX, XIAP, FASLG
21	14-3-3 Induced Intracellular Signaling36	10.6	KITLG, BAD, JUN, FLT1, FLT4, FLT3
22	Apoptosis and survival_FAS signaling cascades41	10.6	BID, BCL2, BAX, XIAP, CFLAR, APAF1
23	Apoptosis and survival TNFR1 signaling pathway10	10.5	BID, BAX, XIAP, CFLAR, JUN, APAF1
24	Apoptosis and survival Apoptotic TNF-family pathways10	10.5	BID, BCL2, BCL2L1, BAX, XIAP, FASLG
25	PAK Pathway36	10.5	KIT, KITLG, BMP6, KDR, BCL2, BAX
26	Small cell lung cancer20	10.5	RB1, MYC, BCL2, BCL2L1, XIAP, CDK6
27	Cyclins and Cell Cycle Regulation36	10.5	RB1, ATM, CDK6, CDKN1A, CDKN2C, CDK2
28	PPAR Pathway36	10.4	KIT, KITLG, ITGA2B, ITGA4, ITGA5, ITGB3
29	MIF Mediated Glucocorticoid Regulation36	10.4	BMP6, BCL2, BAX, CD80, IL11, IL16
30	Apoptosis and survival_TNFR1 signaling pathway41	10.4	BID, BCL2, BAX, XIAP, CFLAR, JUN
31	ILK Signaling36	10.3	KIT, KITLG, KDR, LEF1, BAD, JUN
32	Cellular Apoptosis Pathway36	10.2	KIT, KITLG, BMP6, BID, KDR, BCL2
33	Chronic myeloid leukemia20	10.2	RB1, MYC, BCL2L1, BCR, BAD, CDK6
34	MIF Regulation of Innate Immune Cells36	10.0	BMP6, BCL2, BAX, JUN, CD80, IL11
35	Transcription_P53 signaling pathway41	9.9	RB1, VEGFA, KDR, BCL2, ATM, CDKN1A
36	Natural killer cell mediated cytotoxicity20	9.9	BID, MICB, MICA, MAPK1, IFNA1, IFNA2
37	p53 Mediated Apoptosis36	9.9	KIT, KITLG, BMP6, BID, KDR, BCL2
38	p70S6K Signaling36	9.8	KIT, KITLG, BMP6, KDR, BAD, JAK1
39	Apoptosis through Death Receptors36	9.8	BID, BCL2, BAX, CFLAR, APAF1, MAPK8
40	Glioblastoma Multiforme36	9.7	RB1, LEF1, FZD6, CDK6, CDKN1A, CDK2
41	Prostate cancer20	9.7	RB1, BCL2, LEF1, BAD, MTOR, CDKN1A
42	TGF-Beta Pathway36	9.6	KITLG, BMP6, KDR, BCL2, BAX, JUN
43	Estrogen Pathway36	9.1	NCOA2, NCOR1, NCOR2, KIT, KITLG, BMP6
44	Cell cycle ESR1 regulation of G1/S transition10	9.0	RB1, MYC, JUN, CDK6, CDKN1A, CDK2
45	Colorectal Cancer Metastasis36	8.1	MYC, BIRC5, BCL2L1, LEF1, BAX, MSH2
46	Rho Family GTPases36	INF	KIT, KITLG, BMP6, KDR, BCL2, BAX
47	Pancreatic Adenocarcinoma36	INF	KIT, KITLG, RB1, BMP6, BIRC5, KDR
48	Tuberculosis20	INF	BID, BCL2, BAD, BAX, JAK1, JAK2
49	Breast Cancer Regulation by Stathmin136	INF	, FGF2, MAPK10, CCNE1, CCNB1, CCNE2
50	Molecular Mechanisms of Cancer36	INF	KITLG, RB1, MYC, BMP6, RARA, BID

Compounds related to acute leukemia according to GeneDecks:

(show top 50)    (show all 475)

id	Compound	Score	Top Affiliating Genes
1	arginine32	INF	NCL, NCOA2, REN, VWF, SERPINC1, SERPINF2
2	atp32	16.2	NCAM1, NCL, KIT, RB1, RAN, LIG1
3	cytarabine32 34 9 9	16.2	KIT, KITLG, RB1, MYC, LIG1, BCL2
4	cysteine32	12.8	SELP, SERPINA3, NAT2, MYB, RAG1, RARA
5	gp 13032	12.8	KIT, BMP6, BCL2L1, BCR, MPL, JAK1
6	etoposide32 42 9 9	15.6	RB1, MYC, RARA, LIG1, BID, BIRC5
7	glutamate32	12.6	NCAM1, BMP6, KDR, SDHB, MTRR, MTHFR
8	alanine32	12.6	NCAM1, KITLG, VWF, SELL, SERPINC1, SERPINF2
9	doxorubicin32 34 9 9	15.3	NCAM1, KIT, KITLG, MYB, BMP6, BID
10	glycogen32 18	13.0	KIT, MYC, SDHB, LEF1, MUC1, BAD
11	ethanol32 34 9 18 9	16.0	NCAM1, KITLG, RBP1, BID, SDHB, MUC1
12	cisplatin32 34 9 9	14.9	KITLG, RB1, VEGFA, MYC, BMP6, RAN
13	ascorbic acid32 18	12.8	SDHB, XRCC1, CGA, JAK2, CD40LG, CDK4
14	roscovitine32	11.7	BIRC5, BCL2L1, XIAP, MCL1, CCNB1, CCNA2
15	epinephrine32 9 18 9	14.5	REN, KITLG, SELL, SELP, SERPINF2, BMP6
16	camptothecin32 42 9 9	14.5	NCL, RB1, MYC, BID, BIRC5, KDR
17	aspartate32	11.4	SELP, BMP6, RAG1, RARA, SDHB, B2M
18	ribonucleic acid32	11.3	KIT, KITLG, MYC, BMP6, RARA, MUC1
19	morphine32 9 9	13.1	JUNB, MME, IL1RN, MAPK10, HSP90AA1, CASP2
20	cyclosporin a32 42	12.1	KITLG, VWF, SELP, MYC, MYB, BID
21	histamine32 18	12.1	NCAM1, KIT, KITLG, VWF, SELL, SELP
22	hypoxanthine32 9 18 9	14.0	SELL, B2M, MPO, FPGS, IL4, APEX1
23	biotin32 9 18 9	13.9	KITLG, VWF, RB1, SELL, MUC1, B2M
24	polysaccharide32	10.8	NCAM1, KITLG, SELL, SELP, SERPINC1, SERPINF2
25	2-chlorodeoxyadenosine32	10.8	KIT, BIRC5, BCL2, BAX, XIAP, B2M
26	bleomycin32 9 9	12.7	LIG1, MVP, XRCC1, ATM, GSTM1, GSTP1
27	oxaliplatin32 34 9 9	13.7	VEGFA, BIRC5, BCL2L1, MTHFR, XRCC1, XIAP
28	manganese superoxide32	10.6	BCL2L1, XRCC1, ATM, GSTM1, GSTP1, GSTT1
29	melphalan32 9 9	12.6	BIRC5, BCL2L1, MVP, CD79A, MGMT, GSTP1
30	dutp32	10.5	BIRC5, BCL2, BCL2L1, BAX, XIAP, CFLAR
31	noxa32	10.4	BID, BIRC5, BCL2, BCL2L1, BAD, BAX
32	sulindac32 9 9	12.2	BIRC5, BCL2, BCL2L1, BAX, XIAP, CDKN1A
33	ifn-alpha32	10.1	JAK1, CDK2, CDKN2A, IRF1, IL17A, IL2
34	paclitaxel32 34 9 9	13.1	NCL, KIT, KITLG, RB1, VEGFA, MYC
35	aphidicolin32	10.1	RB1, MYC, LIG1, ATM, CDKN1A, CDK2
36	hyaluronic acid32 18	11.1	MYC, BMP6, MUC1, B2M, CD58, CDH1
37	norepinephrine32 9 18 9	13.1	REN, KITLG, VWF, SELL, SELP, BMP6
38	suramin32 9 9	11.9	NCAM1, VEGFA, BMP6, KDR, P2RX1, P2RX4
39	erlotinib32 34 9 9	12.9	KIT, VEGFA, BIRC5, KDR, MTOR, CDKN1B
40	cd 43732	9.5	MYC, RARA, BID, BCL2, BCL2L1, BAX
41	tgf beta132	9.4	KITLG, BMP6, RARA, KDR, CDK6, CDKN1A
42	gefitinib32 34 9 9	12.0	KIT, SELP, VEGFA, BIRC5, KDR, BCL2L1
43	troglitazone32 42 9 9	12.0	RB1, BMP6, RARA, BIRC5, BCL2, BAX
44	resveratrol32 9 18 9	11.7	RB1, VEGFA, BID, BIRC5, BCL2, BCL2L1
45	mg 13232 42	9.3	NCOA2, NCOR2, MYC, RARA, BID, BIRC5
46	fibrinogen32	INF	SELP, SERPINC1, SERPINF2, SERPINA3, , PADI4
47	dexamethasone32 42 34 9 9	INF	NCAM1, NCOA2, REN, KITLG, VWF, RB1
48	cyclic amp32 18	INF	NCOA2, NCOR1, NCOR2, RB1, BID,
49	cholesterol32 9 18 9	INF	NCOA2, REN, KITLG, VWF, RB1, SELP
50	leucine32	INF	PICALM, KIT, RB1, SERPINA3, MYC, MYB

Cellular components related to acute leukemia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:005654	INF	NCOA2, NCOR1, NCOR2, RB1, MYC, RARA
2	cytoplasm	GO:005737	INF	, KIT, KITLG, PCM1, RBP1, SELP
3	nucleus	GO:005634	INF	ZNF384, PICALM, NCL, NCOA2, NCOR1, NCOR2
4	nucleolus	GO:005730	INF	ZNF384, NCL, NCOR2, SELP, MYC, BMI1
5	plasma membrane	GO:005886	INF	NCAM1, KIT, KITLG, SELL, SELP, SERPINC1
6	integral to plasma membrane	GO:005887	13.0	SELL, SELP, KDR, MUC1, P2RX1, P2RX4
7	transcription factor complex	GO:005667	11.1	LMO2, LEF1, LDB1, LBX1, JUN, CDK2
8	cell surface	GO:009986	10.7	NCAM1, VEGFA, RARA, FUT4, CD59, CD63
9	external side of plasma membrane	GO:009897	10.3	NCAM1, KIT, VWF, SELL, SELP, KDR
10	extracellular region	GO:005576	9.9	NCAM1, KITLG, VWF, SERPINC1, SERPINF2, SERPINA3
11	extracellular space	GO:005615	8.9	REN, KIT, KITLG, SELP, SERPINC1, SERPINF2
12	cytosol	GO:005829	INF	PCM1, NAT2, RAN, BID, BIRC5, BCL2

Biological processes related to acute leukemia according to GeneDecks:

(show top 50)    (show all 68)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	INF	, KIT, KITLG, RARA, RAN, LITAF
2	virus-host interaction	GO:019048	11.9	RB1, RAN, BECN1, KDR, BAX, CFLAR
3	positive regulation of cell proliferation	GO:008284	11.9	KIT, VEGFA, MYC, RARA, BIRC5, KDR
4	immune response	GO:006955	11.8	BMP6, RAG1, CD96, CD86, CD8A, CD274
5	negative regulation of transcription from RNA polymerase II promoter	GO:000122	11.5	NCOA2, NCOR1, NCOR2, MYC, MYB, BMI1
6	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	11.5	MYC, BAD, BAX, P2RX1, JAK2, CDKN1B
7	embryonic hemopoiesis	GO:035162	11.4	KIT, KITLG, LMO2, KDR, MLL, IL3
8	regulation of cyclin-dependent protein kinase activity	GO:000079	11.4	CDKN1A, CDKN2C, CDC37, CDKN2B, CDKN1B, CDKN1C
9	leukocyte migration	GO:050900	11.4	SELL, SELP, CD58, CD34, CD84, ITGA4
10	anti-apoptosis	GO:006916	11.3	BIRC5, BIRC7, BECN1, BCL2, BCL2L1, MUC1
11	B cell differentiation	GO:030183	11.3	RAG1, MSH2, CD79A, CD40LG, ITGA4, FLT3
12	negative regulation of cell proliferation	GO:008285	11.3	BRD7, BECN1, LBX1, CEBPA, JUN, JAK2
13	peptidyl-tyrosine phosphorylation	GO:018108	11.3	KIT, KDR, JAK1, JAK2, FLT1, FLT4
14	phosphatidylinositol-mediated signaling	GO:048015	11.2	BAD, MTOR, CDKN1B, FOXO3, FOXO4, MDM2
15	cytokine-mediated signaling pathway	GO:019221	11.2	NCAM1, KIT, UBC, BAD, B2M, CEBPA
16	blood coagulation	GO:007596	11.2	VWF, SELL, SELP, SERPINC1, SERPINF2, VEGFA
17	induction of apoptosis	GO:006917	11.2	BAD, BAX, CDKN2C, CDKN1B, CDKN2A, IRF1
18	response to lipopolysaccharide	GO:032496	11.0	SELP, P2RX7, JUN, JAK2, IL1A, FASLG
19	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.9	KITLG, VEGFA, MTOR, JAK2, CD80, ITGA5
20	G1 phase of mitotic cell cycle	GO:000080	10.9	RB1, UBC, CDK6, CDKN1A, CDKN2C, CDKN2B
21	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.9	NCOA2, RB1, SERPINF2, VEGFA, LMO2, MYC
22	fibroblast growth factor receptor signaling pathway	GO:008543	10.8	UBC, BAD, MTOR, CDKN1B, FOXO3, FOXO4
23	induction of apoptosis via death domain receptors	GO:008625	10.7	BID, FASLG, FAS, CASP3, TNF, TNFRSF10A
24	G1/S transition of mitotic cell cycle	GO:000082	10.6	RB1, BCL2, UBC, CDK6, CDT1, CDKN1A
25	activation of pro-apoptotic gene products	GO:008633	10.6	MYC, BID, BCL2, BAD, BAX, FASLG
26	cell cycle arrest	GO:007050	10.6	RB1, MYC, MSH2, ATM, CDK6, CDKN1A
27	interferon-gamma-mediated signaling pathway	GO:060333	10.5	NCAM1, B2M, JAK1, JAK2, IRF1, FCGR1A
28	induction of apoptosis by intracellular signals	GO:008629	10.5	MYC, BID, BCL2, BCL2L1, BAD, BAX
29	Notch signaling pathway	GO:007219	10.5	NCOR1, NCOR2, MYC, UBC, FBXW7, DLK1
30	positive regulation of neuron apoptotic process	GO:043525	10.4	BAX, ATM, JUN, FASLG, CASP3, CASP2
31	regulation of immune response	GO:050776	10.4	SELL, B2M, CD96, CD8A, CD40LG, CD34
32	cellular response to mechanical stimulus	GO:071260	10.3	BAD, IRF1, IL1B, FAS, MAPK8, CASP1
33	epidermal growth factor receptor signaling pathway	GO:007173	10.3	UBC, BAD, MTOR, CDKN1B, FOXO3, FOXO4
34	response to hypoxia	GO:001666	10.2	VEGFA, BCL2, XRCC1, ATM, FLT1, IL1A
35	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	SERPINF2, JUN, FLT1, IL6, IL6R, TNF
36	positive regulation of angiogenesis	GO:045766	9.9	VEGFA, KDR, CD34, FLT1, FGF2, IL1A
37	platelet activation	GO:030168	9.9	VWF, SELP, SERPINF2, VEGFA, P2RX1, FZD6
38	humoral immune response	GO:006959	9.8	PAX5, BCL2, MNX1, IL6, IL7, IFNB1
39	response to organic cyclic compound	GO:014070	9.8	SELP, LEF1, P2RX7, MSH2, JUN, JUNB
40	positive regulation of endothelial cell proliferation	GO:001938	9.8	VEGFA, BMP6, KDR, MTOR, JUN, ITGB3
41	response to drug	GO:042493	9.7	REN, MYC, BCL2, MVP, XRCC1, P2RX7
42	negative regulation of apoptotic process	GO:043066	9.7	VEGFA, MYC, KDR, BCL2, BCL2L1, LEF1
43	positive regulation of nitric oxide biosynthetic process	GO:045429	8.3	P2RX4, JAK2, IL1B, IFNG, ICAM1, HSP90AA1
44	induction of apoptosis by extracellular signals	GO:008624	INF	UBC, BAD, BAX, CFLAR, , FASLG
45	positive regulation of apoptotic process	GO:043065	INF	BID, BAD, BAX, P2RX7, ATM, JAK2
46	negative regulation of transcription, DNA-dependent	GO:045892	INF	RB1, BRD7, MYB, RARA, BIRC5, LEF1
47	positive regulation of transcription, DNA-dependent	GO:045893	INF	PICALM, RB1, BRD7, BRPF1, MYC, MYB
48	mitotic cell cycle	GO:000278	INF	PCM1, RB1, LIG1, BIRC5, UBC, AURKB
49	apoptotic process	GO:006915	INF	LITAF, BID, BIRC5, BCL2, BCL2L1, UBC
50	nerve growth factor receptor signaling pathway	GO:048011	INF	UBC, BAD, MTOR, CDKN1B, FOXO3, FOXO4

Molecular functions related to acute leukemia according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	13.3	KIT, VWF, SERPINF2, VEGFA, RAG1, BIRC5
2	ATP binding	GO:005524	11.5	ABCB1, ABCC1, ABCC3, ABCG2, ABL1, EIF2AK2
3	protein kinase binding	GO:019901	11.4	CCND1, CCNA1, HSPB1, TP53, PTEN, PTPN6
4	RNA polymerase II activating transcription factor binding	GO:001102	10.8	EP300, PITX2, CREBBP, CREB1, JUN, LDB1
5	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.5	CASP3, CDKN1C, CDKN2A, CDKN1B, CDKN2B, CDKN2C
6	protein heterodimerization activity	GO:046982	10.4	TLX1, TOP2A, HIF1A, EGFR, NOTCH4, TGFB1
7	growth factor activity	GO:008083	10.3	MDK, F2, THPO, TGFB1, CXCL12, CSF1
8	histone deacetylase binding	GO:042826	10.3	HDAC9, HDAC6, HDAC3, HDAC1, TAL1, TOP2A
9	cytokine activity	GO:005125	9.9	KITLG, VEGFA, FASLG, IFNA2, IFNB1, IFNG
10	enzyme binding	GO:019899	9.7	BIRC7, LDB1, MSH2, MSH3, FOXO4, IL6R
11	protease binding	GO:002020	9.6	F3, TP53, TNF, ELANE, DPP4, UBC
12	transcription factor binding	GO:008134	INF	LEF1, HIF1A, DNMT1, TCF3, RUNX1, HDAC1
13	protein binding	GO:005515	INF	RGS2, MYH9, GATA2, GATA1, HDAC1, HDAC2
14	sequence-specific DNA binding transcription factor activity	GO:003700	INF	CREBBP, NOTCH1, PITX2, WT1, HIF1A, CREB1
15	sequence-specific DNA binding	GO:043565	INF	SUZ12, DLX4, HOXC6, HOXA9, HOXA7, HOXA10