MCID: ACT073
MIFTS: 60

Acute Leukemia malady

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Acute Leukemia

Aliases & Descriptions for Acute Leukemia:

Name: Acute Leukemia 38 12 29 52 14 69
Acute Undifferentiated Leukemia 69
Undifferentiated Leukemia 69
Stem Cell Leukaemia 12
Stem Cell Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12603
ICD10 33 C95.0 C95.00
ICD9CM 35 208.0
NCIt 47 C9298 C9300

Summaries for Acute Leukemia

Disease Ontology : 12 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. These lymphocytes (acute lymphocytic leukemia [ALL]) or myeloid cells (acute myelocytic leukemia [AML]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia.

MalaCards based summary : Acute Leukemia, also known as acute undifferentiated leukemia, is related to leukemia, acute myeloid and acute lymphocytic leukemia. An important gene associated with Acute Leukemia is BAALC (BAALC, MAP3K1 And KLF4 Binding), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Busulfex and Clolar have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Acute leukemia or is a family of serious medical conditions relating to an original diagnosis of... more...

Related Diseases for Acute Leukemia

Diseases in the Leukemia family:

Acute Leukemia Chronic Leukemia
Subacute Leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
id Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 30.6 ANPEP CD33 CD34 CSF3 DNTT FLT3
2 acute lymphocytic leukemia 26.9 ABCB1 AFF1 ANPEP BAALC CD33 CD34
3 acute leukemia of ambiguous lineage 12.1
4 bilineal acute leukemia 11.9
5 leukemia 11.5
6 leukemia, acute lymphoblastic 11.3
7 myelodysplastic syndrome 11.2
8 invasive aspergillosis 11.1
9 megakaryocytic leukemia 11.1
10 childhood leukemia 11.1
11 myeloproliferative neoplasm 11.1
12 chronic eosinophilic leukemia 11.1
13 chronic leukemia 10.8
14 myelodysplastic myeloproliferative cancer 10.8
15 leukemia, acute promyelocytic, somatic 10.8
16 acute motor-sensory axonal neuropathy 10.3 FLT3 MPO
17 glycogen storage disease type 0 10.3 FLT3 KMT2A WT1
18 chondromyxoid fibroma 10.3 KMT2A MLLT3
19 villous adenoma 10.3 GSTM1 MPO MTHFR
20 pharc syndrome 10.3 ABCB1 CSF3 MTHFR
21 acute necrotizing encephalopathy 10.3 ANPEP KMT2A MPO
22 unilateral hemispheric polymicrogyria 10.3 FLT3 RUNX1
23 nephrotic syndrome type 11 10.2 AFF1 KMT2A MLLT3
24 eosinophilic cystitis 10.2 ABCB1 CSF3
25 familial hyperaldosteronism 10.2 CSF3 FLT3 RUNX1 WT1
26 actinobacillosis 10.2 CSF3 FLT3 MPO RUNX1
27 lymphoma, small cleaved-cell, diffuse 10.2 DNTT KMT2A MPO
28 thompson baraitser syndrome 10.2 ANPEP DNTT RUNX1
29 acute myocardial infarction 10.2 ABCB1 FLT3 GSTM1 MTHFR RUNX1
30 renal oncocytoma 10.2
31 chromophobe renal cell carcinoma 10.2
32 neurofibromatosis 10.2 DNTT FLT3 KMT2A MPO
33 hematopoietic stem cell transplantation 10.2
34 adult acute lymphocytic leukemia 10.2 ABCB1 CSF3 GSTM1 MTHFR RUNX1
35 necrotic uveal melanoma 10.1 AFF1 CREBBP FLT3 MLLT3
36 mixed astrocytoma-ependymoma-oligodendroglioma 10.1 KMT2A MLLT3 MTHFR RUNX1 TCF3
37 adult respiratory distress syndrome 10.1 CREBBP FLT3 KMT2A MLLT3 MPO
38 myeloid leukemia 10.1
39 lymphoma 10.1
40 amblyopia 10.1 AFF1 ANPEP FLT3 MTHFR RUNX1 TCF3
41 adult spinal cord ependymoma 10.1 CD34 MPO
42 liver disease 10.0 AFF1 BAALC FLT3 MLLT3 MTHFR RUNX1
43 paranasal sinus disease 10.0 CD34 CSF3
44 lymphoblastic leukemia 10.0
45 circumscribed cutaneous aplasia of the vertex 10.0 AFF1 CD34 CSF3 KMT2A
46 adducted thumbs dundar type 10.0 CREBBP DNTT FLT3 KMT2A MPO RUNX1
47 hemophagocytic lymphohistiocytosis 10.0 ABCB1 CSF3 DNTT FLT3 KMT2A RUNX1
48 beach ear 9.9 CD34 CSF3
49 hyperparathyroidism, neonatal 9.9 CD34 CSF3 FLT3 GSTM1
50 phencyclidine abuse 9.9 CD34 WT1

Comorbidity relations with Acute Leukemia via Phenotypic Disease Network (PDN):


Deficiency Anemia Neutropenia

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to Acute Leukemia

Symptoms & Phenotypes for Acute Leukemia

MGI Mouse Phenotypes related to Acute Leukemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 RUNX1 TCF3 WT1 ABCB1 AFF1 ANPEP
2 homeostasis/metabolism MP:0005376 10.18 ABCB1 CD34 CREBBP DNTT FLT3 KMT2A
3 growth/size/body region MP:0005378 10.17 ZNF384 ABCB1 AFF1 CREBBP FLT3 KMT2A
4 immune system MP:0005387 10.17 ABCB1 AFF1 ANPEP CD34 CREBBP CSF3
5 cardiovascular system MP:0005385 10.13 ABCB1 ANPEP CREBBP DNTT KMT2A MPO
6 endocrine/exocrine gland MP:0005379 10.11 ZNF384 ABCB1 AFF1 ANPEP CREBBP FLT3
7 integument MP:0010771 9.86 ANPEP CD34 CREBBP CSF3 KMT2A MTHFR
8 neoplasm MP:0002006 9.76 FLT3 KMT2A MLLT3 RUNX1 TCF3 WT1
9 no phenotypic analysis MP:0003012 9.61 ABCB1 AFF1 FLT3 KMT2A MLLT3 MTHFR
10 reproductive system MP:0005389 9.23 ABCB1 AFF1 ANPEP KMT2A MTHFR TCF3

Drugs & Therapeutics for Acute Leukemia

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Busulfex 17 46 BUSULFAN Orphan Medical Approved February 1999
2
Clolar 17 46 CLOFARABINE Genzyme Approved December, 2004
3
Marqibo 17 46 VINCRISTINE SULFATE Talon Therapeutics Approved August 2012

Drugs for Acute Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 758)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Arsenic trioxide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 1327-53-3 518740
2
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
3
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
4
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58957-92-9 42890
5
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
6
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
7
Vidarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 24356-66-9 32326 21704
8
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
10
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
11
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
12
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
13
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
16
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
17
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
18
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
19
Azacitidine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 320-67-2 9444
20
Decitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 2353-33-5 451668
21
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 4291-63-8 20279
22
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
23
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
24
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
25
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
26
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
27
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
28
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
30
Topotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 119413-54-6, 123948-87-8 60700
31
Amsacrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51264-14-3 2179
32
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
33
Aldesleukin Approved Phase 4,Phase 3,Phase 2,Phase 1 85898-30-2, 110942-02-4
34
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 75614-87-8, 51-45-6 774
35
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
36
Oprelvekin Approved, Investigational Phase 4,Phase 2,Phase 3 145941-26-0
37
Ketamine Approved, Vet_approved Phase 4,Phase 3 6740-88-1 3821
38
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
39
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
40
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 55-98-1 2478
41
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
42
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
43
alemtuzumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216503-57-0
44
Diphenhydramine Approved Phase 4,Phase 2,Phase 1 58-73-1, 147-24-0 3100
45
Promethazine Approved Phase 4,Phase 2,Phase 1 60-87-7 4927
46
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
47
Lenalidomide Approved Phase 4,Phase 3,Phase 2,Phase 1 191732-72-6 216326
48
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
49
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
50
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912

Interventional clinical trials:

(show top 50) (show all 3503)
id Name Status NCT ID Phase
1 Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic Unknown status NCT00196768 Phase 4
2 AIDA2000 - Risk-Adapted Therapy for Patients With Acute Promyelocytic Leukemia Unknown status NCT00180128 Phase 4
3 Idarubicin at Different Dosages as Induction Therapy for Newly Diagnosed Acute Myeloid Leukaemia Unknown status NCT02277847 Phase 4
4 AML1-ETO Acute Myeloid Leukemia With Fludarabine and Cytarabine Chemotherapy Unknown status NCT02024308 Phase 4
5 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4
6 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4
7 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4
8 3 Anthracyclines, 2 Types of Consolidation With Different ARA-C Doses and Maintenance in Adult Acute Myeloid Leukemia Unknown status NCT01587430 Phase 4
9 Decitabine for Myelodysplastic Syndromes and Acute Myeloid Leukemia Before Allogeneic Hematopoietic Cell Transplantation Unknown status NCT01806116 Phase 4
10 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4
11 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4
12 Efficacy of G-CSF-Priming in Elderly AML Patients Unknown status NCT00199147 Phase 4
13 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4
14 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
15 PROPHYSOME: Pilot Study on Safety of a Weekly Administration of 10mg/kg of AmBisome® in Antifungal Prophylaxis Treatment of Allogeneic Stem-cell Transplantation and Acute Leukaemia Completed NCT00362544 Phase 4
16 Optimized Radiological Diagnosis of Hepatic Candidiasis During the Treatment of Acute Leukemias Completed NCT01207843 Phase 4
17 Treatment of Relapsed Promyelocytic Leukemia With Arsenic Trioxide (ATO) Completed NCT00504764 Phase 4
18 Analysis of Data Collected in the European Group for Blood and Marrow Transplantation (EBMT) Registry for Off-Label Transplant Use of Plerixafor Completed NCT01362985 Phase 4
19 LAM07: Study to Analyze the Efficacy of a Risk Adapted Treatment Strategy, Including Gemtuzumab Ozogamicin (GO) During Consolidation, for Patients With Acute Myeloid Leukemia (AML) Completed NCT01041040 Phase 4
20 Treatment of the Acute Myeloblastic Leukaemia in Patients Over 65 Years Completed NCT00464217 Phase 4
21 Fludarabine, Cytarabine, Topotecan in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT00488709 Phase 4
22 Treatment of Acute Promyelocytic Leukemia With All-Trans Retinoic Acid (ATRA) and Idarubicin (AIDA) Completed NCT00465933 Phase 4
23 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4
24 Treatment of Newly Diagnosed Patients With Acute Promyelocytic Leukemia (PETHEMA LPA 2005) Completed NCT00408278 Phase 4
25 AML2003 - Standard-Therapy vs Intensified Therapy for Adult Acute Myeloid Leukemia Patients <= 60 Years Completed NCT00180102 Phase 4
26 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4
27 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4
28 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4
29 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4
30 Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia Completed NCT01457040 Phase 4
31 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4
32 Treatment of Acute Myeloblastic Leukemia in Younger Patients Completed NCT00390715 Phase 4
33 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4
34 AML96 - Risk-Adapted and Randomized Postremission-Therapy for Adult Acute Myeloid Leukemia Patients Completed NCT00180115 Phase 4
35 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
36 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4
37 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4
38 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4
39 Maintenance Therapy With Ceplene® (Histamine) and IL-2 on Immune Response and MRD in Acute Myeloid Leukemia Completed NCT01347996 Phase 4
40 Study Evaluating the Effect of Corticosteroids on Mylotarg® Infusion-Related Adverse Events in Patients With Leukemia Completed NCT00304447 Phase 4
41 Therapy of Acute Myeloid Leukemia in Patients Over the Age of 60 : DA Versus Mitoxantrone With Intermittent AraC Completed NCT00180167 Phase 4
42 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4
43 Study Evaluating Mylotarg (Gemtuzumab Ozogamicin) in Usual Care Completed NCT00161668 Phase 4
44 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4
45 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4
46 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4
47 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4
48 Efficacy of Dexamethasone for Prevent Vomiting in Leukemic Children Who Receive Intrathecal Chemotherapy Completed NCT01094990 Phase 4
49 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4
50 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4

Search NIH Clinical Center for Acute Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:
Promostem

Genetic Tests for Acute Leukemia

Genetic tests related to Acute Leukemia:

id Genetic test Affiliating Genes
1 Acute Leukemia 29

Anatomical Context for Acute Leukemia

MalaCards organs/tissues related to Acute Leukemia:

39
Myeloid, Bone, Bone Marrow, T Cells, Lung, Breast, Nk Cells

Publications for Acute Leukemia

Articles related to Acute Leukemia:

(show top 50) (show all 1604)
id Title Authors Year
1
Phase I Trial of Total Marrow and Lymphoid Irradiation Transplant Conditioning in Patients with Relapsed/Refractory Acute Leukemia. ( 28087456 )
2017
2
Postinduction Minimal Residual Disease Predicts Outcome and Benefit From Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia With NPM1 Mutation: A Study by the Acute Leukemia French Association Group. ( 28056203 )
2017
3
Correction: Rapidly Progressing Myelodysplastic Syndrome Initially Presenting as Acute Leukemia. ( 28465876 )
2017
4
Risk of sinusoidal obstruction syndrome in allogeneic stem cell transplantation after prior gemtuzumab ozogamicin treatment: a retrospective study from the Acute Leukemia Working Party of the EBMT. ( 28092357 )
2017
5
Plasma cell neoplasm with plasmablastic morphology mimicking acute leukemia. ( 28057674 )
2017
6
An Unlikely Rapid Transformation of Myelodysplastic Syndrome to Acute Leukemia: A Case Report. ( 28488979 )
2017
7
Impact of FAB Classification on Predicting Outcome in Acute Myeloid Leukemia, Not Otherwise Specified, Patients Undergoing Allogeneic Stem Cell Transplantation in CR1: An Analysis of 1690 Patients from the Acute Leukemia Working Party of EBMT. ( 28052366 )
2017
8
Triple-hit blastoid mantle cell lymphoma presenting like acute leukemia. ( 28473415 )
2017
9
Typhlitis (neutropenic enterocolitis) in patients with acute leukemia: a review. ( 28075196 )
2017
10
Spontaneous Fracture and Migration of a Totally Implanted Port Device to Pulmonary Artery in Acute Leukemia Child. ( 28060112 )
2017
11
Effect of donor STAT4 polymorphism rs7574865 on clinical outcomes of pediatric acute leukemia patients after hematopoietic stem cell transplant. ( 27960128 )
2017
12
A Case of Therapy-Related Acute Leukemia With Mixed Phenotype With BCR-ABL1 After Treatment of Diffuse Large B-Cell Lymphoma. ( 28029006 )
2017
13
Chediak Higashi Syndrome in Accelerated phase mascquerading as acute leukemia. ( 27093962 )
2016
14
Peripheral blood stem cell versus bone marrow transplantation: A perspective from the Acute Leukemia Working Party of the European Society forA BloodA and Marrow Transplantation. ( 27106798 )
2016
15
Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia. ( 27547725 )
2016
16
Mutational analysis of TP53 gene in Tunisian familial hematological malignancies and sporadic acute leukemia cases. ( 27619989 )
2016
17
Identification of Heme Oxygenase-1 as a Novel Predictor of Hematopoietic Stem Cell Transplantation Outcomes in Acute Leukemia. ( 27606430 )
2016
18
Transplantation after Remission in Mixed Phenotype Acute Leukemia: A Good Idea. ( 27095690 )
2016
19
Hepatosplenic T-cell lymphoma: an acute leukemia presentation. ( 27158719 )
2016
20
Mixed-phenotype acute leukemia (MPAL) and beyond. ( 28090479 )
2016
21
Inhibitor of pan class-I PI3K induces differentially apoptotic pathways in acute leukemia cells: Shedding new light on NVP-BKM120 mechanism of action. ( 27599915 )
2016
22
Prevalence and risk factors of iron overload after hematopoietic stem cell transplantation for childhood acute leukemia: a LEA study. ( 27595286 )
2016
23
Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia. ( 27620872 )
2016
24
Scientific Achievements May Not Reach Everyone: Understanding Disparities in Acute Leukemia. ( 27209407 )
2016
25
Second allogeneic stem cell transplantation for acute leukemia using a chemotherapy only cytoreduction with clofarabine, melphalan, and thiotepa. ( 27184623 )
2016
26
Exploitation of Natural Killer (NK) cells for the treatment of acute leukemia. ( 27207791 )
2016
27
Survivin and cyclin E2 genes expression in a cohort of Egyptian acute leukemia patients: Clinical importance and future prospects. ( 26600399 )
2016
28
Detection of Merkel Cell Polyoma Virus and Beta Human Papillomavirus in Multiple Eccrine Poromas in a Patient With Acute Leukemia Treated With Stem Cell Transplant. ( 27655121 )
2016
29
Selective activation of TNFR1 and NF-I_B inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells. ( 27098354 )
2016
30
Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone. ( 27150875 )
2016
31
Antibody Based Therapies in Acute Leukemia. ( 27593687 )
2016
32
Single versus double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome. ( 27099151 )
2016
33
Carotidynia Heralding the Onset of Acute Leukemia. ( 27068855 )
2016
34
The Total Body Irradiation Schedule Affects Acute Leukemia Relapse After Matched T Cell-Depleted Hematopoietic Stem Cell Transplantation. ( 27623308 )
2016
35
Mixed Phenotype Acute Leukemia Presenting as Leukemia Cutis. ( 27956900 )
2016
36
Red blood cell transfusion triggers in acute leukemia: a randomized pilot study. ( 27198129 )
2016
37
BCR-ABL (Ph)-like acute leukemia-Pathogenesis, diagnosis and therapeutic options. ( 27665024 )
2016
38
Ocular manifestation in myeloid/NK cell precursor acute leukemia: a case report. Diagnosed by flow cytometry and PCR from aqueous humor. ( 27661058 )
2016
39
Multiplexed automated digital quantification of fusion transcripts: comparative study with fluorescent in-situ hybridization (FISH) technique in acute leukemia patients. ( 27632978 )
2016
40
Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors. ( 26259531 )
2016
41
The formation of an aberrant PAX5 transcript in a patient with mixed phenotype acute leukemia harboring der(9)t(7;9)(q11.2;p13). ( 27144120 )
2016
42
Mixed Phenotype Acute Leukemia (MPAL) Exhibits Frequent Mutations in DNMT3A and Activated Signaling Genes. ( 27208809 )
2016
43
Bilineal Acute Leukemia Associated With Fanconi Syndrome: The First Case Report. ( 27617066 )
2016
44
Graft-Versus-Host Disease in Adolescents and Young Adults (15-24 Years Old) After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia in First Complete Remission. ( 27983886 )
2016
45
FLAG Regimen with or without Idarubicin in Children with Relapsed/Refractory Acute Leukemia: Experience from a Turkish Pediatric Hematology Center. ( 27095144 )
2016
46
Minimal residual disease- and graft-vs.-host disease-guided multiple consolidation chemotherapy and donor lymphocyte infusion prevent second acute leukemia relapse after allotransplant. ( 27629395 )
2016
47
Acute leukemia in pregnancy: a single institution experience with 23 patients. ( 27562538 )
2016
48
Clinical significance of microRNA-34b expression in pediatric acute leukemia. ( 26861642 )
2016
49
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia. ( 28018601 )
2016
50
The Use of Hydroxyurea and Leukapheresis in Childhood Acute Leukemia With Hyperleukocytosis. ( 27164521 )
2016

Variations for Acute Leukemia

Expression for Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Pathways for Acute Leukemia

GO Terms for Acute Leukemia

Cellular components related to Acute Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 AFF1 ANPEP BAALC CD33 CREBBP DNTT

Biological processes related to Acute Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.8 CREBBP CSF3 KMT2A RUNX1 TCF3 WT1
2 positive regulation of transcription, DNA-templated GO:0045893 9.65 CREBBP KMT2A RUNX1 TCF3 WT1
3 hematopoietic stem cell proliferation GO:0071425 9.16 CD34 RUNX1
4 hemopoiesis GO:0030097 9.13 CD34 FLT3 RUNX1
5 stem cell proliferation GO:0072089 8.62 ABCB1 CD34

Molecular functions related to Acute Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.1 AFF1 CREBBP KMT2A RUNX1 TCF3 WT1

Sources for Acute Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....