MCID: ACT073
MIFTS: 56

Acute Leukemia malady

Cancer diseases category
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Summaries for Acute Leukemia

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. these lymphocytes (acute lymphocytic leukemia [all]) or myeloid cells (acute myelocytic leukemia [aml]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia. because they are bloodborne, they can infiltrate various organs and sites, including the liver, spleen, lymph nodes, cns, kidneys, and gonads.

MalaCards: Acute Leukemia, also known as stem cell leukemia, is related to leukemia and myelodysplastic syndromes. An important gene associated with Acute Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are Hematopoietic cell lineage and Transcriptional misregulation in cancer. The compounds p00001 and etoposide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are reproductive system and renal/urinary system.

Wikipedia:65 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

Description from OMIM:47 308960

Aliases & Classifications for Acute Leukemia

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8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 40NCIt, 58SNOMED-CT, 47OMIM, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

acute leukemia 8 10 45 31
stem cell leukemia 8 10
acute undifferentiated leukemia 62
stem cell leukaemia 8


External Ids:

Disease Ontology8 DOID:12603
NCIt40 C9298, C9300
OMIM47 308960
ICD9CM27 208.0

Related Diseases for Acute Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Leukemia family:

acute leukemia Subacute Leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.7HOXA9, HOXA7, ID4, KMT2A, TCF3, PRAME
2myelodysplastic syndromes31.0KMT2A, DNTT, HOXA9
3myeloid leukemia30.9HOXA9, IL3RA, DNTT, KMT2A
4chronic myeloid leukemia30.3PRAME, HOXA9, KMT2A, TAL1, DNTT, FOXO3
5lymphoblastic lymphoma30.3KMT2A, DNTT, TAL1, CD7
6non-hodgkin lymphoma30.2TAL1, DNTT, KMT2A
7megakaryocytic leukemia30.2KMT2A, MKL1
8myeloid sarcoma30.2DNTT, KMT2A
9chronic lymphocytic leukemia30.1DNTT, IL3RA, KMT2A
10acute myelomonocytic leukemia30.0DNTT, KMT2A
11leukemia, acute nonlymphocytic29.9CD7, DNTT, KMT2A
12acute lymphocytic leukemia29.8TRD, CD7, TAL1, HOXA9, KMT2A, TCF3
13hematopoietic stem cell transplantation10.6
14acute myeloid leukemia10.6
15lymphoblastic leukemia10.5
16acute biphenotypic leukemia10.4
17wilms tumor10.4
18aspergillosis10.4
19granulocytopenia10.4
20myeloma10.4
21multiple myeloma10.3
22graft versus host disease10.3
23breast cancer10.3
24candidiasis10.3
25endotheliitis10.3
26refractory anemia10.3
27invasive aspergillosis10.3
28down syndrome10.3
29disseminated intravascular coagulation10.3
30hepatitis10.3
31neutropenia10.3
32blindness10.3
33rhabdomyosarcoma10.2
34sarcoma10.2
35sideroblastic anemia10.2
36tetraploidy10.2
37alveolar rhabdomyosarcoma10.1
38oral candidiasis10.1
39pernicious anemia10.1
40histiocytosis10.1
41hodgkin's lymphoma10.1
42neuroblastoma10.1
43thrombocytopenia10.1
44acute promyelocytic leukemia10.1
45chronic myelomonocytic leukemia10.1
46myeloproliferative disorder10.1
47leukopenia10.1
48bilineal acute leukemia10.1
49priapism10.1
50myeloid neoplasm associated with fgfr1 rearrangement10.1

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to acute leukemia

Symptoms for Acute Leukemia

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47OMIM
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Clinical features from OMIM:

308960

Drugs & Therapeutics for Acute Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Leukemia

Search NIH Clinical Center for Acute Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:
Promostem

Genetic Tests for Acute Leukemia

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Anatomical Context for Acute Leukemia

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33MalaCards
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MalaCards organs/tissues related to Acute Leukemia:

33
Myeloid, Bone, Bone marrow, T cells, Lymph node, Liver, Spleen, Kidney, Lung, Breast, Endothelial, Nk cells, B cells, Testes, Monocytes, Brain, Thyroid, Skin, Skeletal muscle

Animal Models for Acute Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.1KMT2A, TCF3, FOXO3, MTHFR, ZNF384, HOXA9
2MP:00053679.1TCF3, TAL1, TRD, FOXO3, KMT2A
3MP:00107718.8TRD, HOXA9, MKL1, KMT2A, TCF3, FOXO3
4MP:00053908.6HOXA7, ID4, KMT2A, MTHFR, TAL1, ZNF384
5MP:00053788.4TAL1, HOXA9, ZNF384, MKL1, ID4, KMT2A
6MP:00053977.6HOXA7, HOXA9, TRD, CD7, MXD1, TAL1
7MP:00053877.6MXD1, TAL1, CD7, LYL1, TRD, DNTT

Publications for Acute Leukemia

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52PubMed
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Articles related to Acute Leukemia:

(show top 50)    (show all 1393)
idTitleAuthorsYear
1
MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia. (23522449)
2013
2
Expression of homeobox gene HOXA9 in childhood acute leukemia, and its clinical significance]. (23607948)
2013
3
Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-retinoid Acid Receptor I+ Rearrangement. (24416501)
2013
4
Pre-clinical evaluation of tyrosine kinase inhibitors for treatment of acute leukemia. (24084362)
2013
5
The impact of center experience on results of reduced intensity: allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT. (22773125)
2013
6
NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. (24184354)
2013
7
CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia. (22261446)
2012
8
Evaluation of multidrug resistance in 46 newly diagnosed patients with acute leukemia. (22664042)
2012
9
124I-anti-CD52 dosimetry before radioimmunotherapy as part of conditioning for stem cell transplantation in acute leukemia. (22391715)
2012
10
Measurements of treatment response in childhood acute leukemia. (23320002)
2012
11
Association of insulin like growth factor-1 (IGF-1) and thyroid hormones in patients of acute leukemia. (22582495)
2012
12
Hematopoietic stem cell transplantation rates and long-term survival in acute myeloid and lymphoblastic leukemia: real-world population-based data from the Swedish Acute Leukemia Registry 1997-2006. (21387283)
2011
13
Abnormal expression of P2X family receptors in Chinese pediatric acute leukemias. (19919827)
2010
14
Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study. (19353239)
2009
15
Association of CYP2B6 G15631T polymorphism with acute leukemia susceptibility. (19144407)
2009
16
Analysis of NOTCH1 extracellular juxtamembrane expansion mutations in acute leukemias and multiple myelomas. (19239437)
2009
17
Effect of priming with granulocyte-macrophage colony-stimulating factor in younger adults with newly diagnosed acute myeloid leukemia: a trial by the Acute Leukemia French Association (ALFA) Group. (17252021)
2007
18
ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells. (16956752)
2006
19
IgH and TCRgamma gene rearrangements, cyclin A1 and HOXA9 gene expression in biphenotypic acute leukemias. (16102826)
2006
20
Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia. (16614510)
2006
21
Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. (15388581)
2005
22
Acremonium pyomyositis in a pediatric patient with acute leukemia. (15593233)
2005
23
Study on clinical and biological characteristics of childhood acute leukemia with MLL gene rearrangements]. (16383239)
2005
24
Interleukin-3 receptor in acute leukemia. (14671644)
2004
25
Survivin expression in acute leukemias and myelodysplastic syndromes. (15512811)
2004
26
Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. (14726393)
2004
27
Study on efficacy of treatment of acute leukemia by shengfu injection in combination with chemotherapy and the effect on cellular immunity, serum interleukin-6 and tumor necrosis factor-alpha levels]. (12764905)
2003
28
Expression of transporter associated with antigen processing (TAP) in childhood acute leukemia and its clinical significance]. (14558951)
2003
29
Treatment of refractory acute leukemia with timed sequential chemotherapy using topotecan followed by etoposide + mitoxantrone (T-EM) and correlation with topoisomerase II levels. (12148910)
2002
30
Quantitative analysis of a MDR1 transcript for prediction of drug resistance in acute leukemia. (12028995)
2002
31
Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. (11234890)
2001
32
Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. (11090076)
2000
33
Temporary remission of an alveolar rhabdomyosarcoma diagnosed and treated as acute leukemia. (10674913)
2000
34
BP1, a new homeobox gene, is frequently expressed in acute leukemias. (11069021)
2000
35
E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia. (11106238)
2000
36
Thiorphan, an inhibitor of neutral endopeptidase/enkephalinase (CD10/CALLA) enhances cell proliferation in bone marrow cultures of patients with acute leukemia in remission. (10841318)
2000
37
Alterations in subnuclear trafficking of nuclear regulatory factors in acute leukemia. (11389537)
2000
38
Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1. (10339498)
1999
39
Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl. (9096694)
1997
40
Terminal transferase expression in the differential diagnosis of acute leukemias. Eastern Cooperative Oncology Group. (8819075)
1996
41
Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia. (8943879)
1996
42
Transcobalamin II levels in blood plasma of children with acute leukemia]. (8754152)
1996
43
Usefulness of immunocytochemistry for phenotypical analysis of acute leukemia; improved fixation procedure and comparative study with flow cytometry. (7719239)
1995
44
Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. (7596170)
1995
45
Characterization of translocation t(1;14)(p32;q11) in a T and in a B acute leukemia. (8412312)
1993
46
Immunological detection of myeloperoxidase in poorly differentiated acute leukemia. (8386105)
1993
47
Biological parameters of the efficiency of retinoic acid in acute leukemia]. (1822394)
1991
48
Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. (1701841)
1990
49
Testicular disease in Singapore children with acute leukemia. (6595957)
1984
50
Serum migration-inhibitory activity in patients with acute leukemia and early leukemic lymphosarcoma. (387315)
1979

Variations for Acute Leukemia

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Expression for genes affiliated with Acute Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Pathways for genes affiliated with Acute Leukemia

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50PathCards, 30KEGG
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Pathways related to Acute Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CD7, DNTT, IL3RA
29.2TAF15, LYL1, TCF3, KMT2A, HOXA9

Compounds for genes affiliated with Acute Leukemia

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45Novoseek, 51PharmGKB, 61Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Acute Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1p000014510.1MTHFR, KMT2A
2etoposide45 51 61 1112.4TAL1, DNTT, FOXO3, KMT2A
3retinoic acid45 2410.1KMT2A, MTHFR, DNTT, MXD1, TAL1

GO Terms for genes affiliated with Acute Leukemia

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16Gene Ontology
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Cellular components related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.8TAL1, HOXA7, MKL1, ID4, KMT2A, TCF3

Biological processes related to Acute Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:0351629.9KMT2A, TAL1
2definitive hemopoiesisGO:0602169.9LYL1, TAL1
3positive regulation of erythrocyte differentiationGO:0456489.8FOXO3, TAL1
4negative regulation of transcription from RNA polymerase II promoterGO:0001229.3HOXA7, ID4, FOXO3, TAL1
5positive regulation of transcription, DNA-templatedGO:0458939.1TCF3, LYL1, FOXO3, TAF15, TAL1, KMT2A
6positive regulation of transcription from RNA polymerase II promoterGO:0459448.7TCF3, ZNF384, TAL1, ID4, KMT2A, MKL1
7transcription, DNA-templatedGO:0063518.3HOXA9, HOXA7, MKL1, TCF3, PRAME, LYL1

Molecular functions related to Acute Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:07088810.0TAL1, TCF3
2transcription regulatory region DNA bindingGO:0442129.9TCF3, KMT2A, TAL1
3protein dimerization activityGO:0469839.5ID4, LYL1, MXD1
4RNA polymerase II transcription factor bindingGO:0010859.5TAL1, ID4
5sequence-specific DNA bindingGO:0435659.4ZNF384, HOXA9, HOXA7, TCF3, FOXO3
6DNA bindingGO:0036779.0TAF15, MXD1, DNTT, TCF3, FOXO3, LYL1
7sequence-specific DNA binding transcription factor activityGO:0037008.8MKL1, TCF3, FOXO3, MXD1, TAL1, HOXA7
8protein bindingGO:0055157.8TAL1, TAF15, FOXO3, HOXA9, PRAME, TCF3

Products for genes affiliated with Acute Leukemia

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Sources for Acute Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet