MCID: ACT073
MIFTS: 62

Acute Leukemia malady

Summaries for Acute Leukemia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity. these lymphocytes (acute lymphocytic leukemia [all]) or myeloid cells (acute myelocytic leukemia [aml]) proliferate abnormally, replacing normal marrow tissue and hematopoietic cells and inducing anemia, thrombocytopenia, and granulocytopenia. because they are bloodborne, they can infiltrate various organs and sites, including the liver, spleen, lymph nodes, cns, kidneys, and gonads.

MalaCards: Acute Leukemia, also known as stem cell leukemia, is related to leukemia and myeloid leukemia. An important gene associated with Acute Leukemia is MKL1 (megakaryoblastic leukemia (translocation) 1), and among its related pathways are Transcriptional misregulation in cancer and Hematopoietic cell lineage. The compounds retinoic acid and etoposide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, t cells and monocytes, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:63 Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original... more...

Description from OMIM:46 308960

Aliases & Classifications for Acute Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 46OMIM
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Aliases & Descriptions:

acute leukemia 8 10 44 30
stem cell leukemia 8 10
acute undifferentiated leukemia 60
stem cell leukaemia 8


External Ids:

Disease Ontology8 DOID:12603
ICD9CM27 208.0
NCIt39 C9298, C9300
OMIM46 308960

Related Diseases for Acute Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Leukemia family:

Subacute Leukemia acute leukemia

Diseases related to Acute Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 197)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.2CDKN2B, CD7, HOXA7, HOXA9, IL3RA, TAL1
2myeloid leukemia31.2WT1, FLT3, MPO, DNTT, CDKN2B, HOXA9
3acute lymphocytic leukemia30.8WT1, TCF3, TAL1, IL3RA, FLT3, MPO
4myeloma30.5CDKN2B, DNTT
5breast cancer30.4IL3RA, MTHFR, FLT3, FOXO3
6chronic myeloid leukemia30.3WT1, FOXO3, FLT3, MPO, PRAME, DNTT
7down syndrome30.3MTHFR, FLT3
8megakaryocytic leukemia30.3MKL1, MPO
9sarcoma30.3TAF15, WT1
10non-hodgkin lymphoma30.2FLT3, DNTT, CDKN2B, TAL1
11acute monocytic leukemia30.2MPO
12chronic lymphocytic leukemia30.0FLT3, DNTT, CDKN2B, IL3RA
13myeloid sarcoma30.0MPO
14retinoblastoma30.0CDKN2B, WT1
15myelodysplastic syndromes29.8WT1, FLT3, MPO, DNTT, CDKN2B, HOXA9
16melanoma29.8CDKN2B, PRAME, FLT3
17chronic myeloproliferative disease29.8FLT3
18thyroid cancer29.8FLT3
19leukemia, acute nonlymphocytic29.8DNTT, CD7
20childhood leukemia10.9
21acute myeloid leukemia10.8
22acute t cell leukemia10.7
23t-cell leukemia10.6
24lymphoblastic leukemia10.6
25lymphoid leukemia10.4
26natural killer cell leukemia10.4
27acute undifferentiated leukemia10.4
28aspergillosis10.4
29invasive aspergillosis10.3
30multiple myeloma10.3
31acute biphenotypic leukemia10.3
32graft versus host disease10.3
33candidiasis10.3
34disseminated intravascular coagulation10.2
35hepatitis10.2
36neutropenia10.2
378p11 myeloproliferative syndrome10.2
38central nervous system leukemia10.2
39rhabdomyosarcoma10.2
40sideroblastic anemia10.2
41thymoma10.1
42alveolar rhabdomyosarcoma10.1
43adult lymphoma10.1
44pernicious anemia10.1
45oral candidiasis10.1
46histiocytosis10.1
47hodgkin's lymphoma10.1
48monocytic leukemia10.1
49neuroblastoma10.1
50thrombocytopenia10.1

Graphical network of the top 20 diseases related to Acute Leukemia:



Diseases related to acute leukemia

Clinical Features for Acute Leukemia

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46OMIM
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Clinical features from OMIM:

308960

Drugs & Therapeutics for Acute Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Leukemia

Search NIH Clinical Center for Acute Leukemia

Search CenterWatch for Acute Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Leukemia:
Promostem

Genetic Tests for Acute Leukemia

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Anatomical Context for Acute Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute Leukemia:

32
Myeloid, T cells, Monocytes, Bone, Bone marrow, B cells, Liver, Endothelial, Breast, Kidney, Spleen, Lung, Lymph node, Skin, Brain, Thyroid, Testes, Nk cells, B lymphoblasts, Testis, Pituitary, Thymus, Colon, Spinal cord, Pineal, Prostate, Tonsil, Whole blood, Small intestine, Tongue, Temporal lobe, Eye, Skeletal muscle, Cerebellum, Heart, Cervix, Pancreas, Adipocyte, Placenta, Uterus, Smooth muscle

Animal Models for Acute Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.2TCF3, WT1, FOXO3, FLT3, MPO, DNTT
2MP:000538712.1DNTT, MPO, FLT3, FOXO3, WT1, CDKN2B
3MP:000538911.4FOXO3, MTHFR, CDKN2B, HOXA9, TCF3, ZNF384
4MP:000538411.4WT1, FOXO3, FLT3, MKL1, DNTT, CDKN2B
5MP:001077111.1MKL1, CDKN2B, HOXA9, TAL1, TCF3

Publications for Acute Leukemia

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50PubMed
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Articles related to Acute Leukemia:

(show top 50)    (show all 10128)
idTitleAuthorsYear
1
Targeting acute myeloid leukemia with a proapoptotic peptide conjugated to a Toll-like receptor 2-mediated cell-penetrating peptide. (23852533)
2014
2
Data quality in the Danish National Acute Leukemia Registry: a hematological data resource. (24039451)
2013
3
Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity. (24283803)
2013
4
EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells. (23974111)
2013
5
Disseminated amphotericin-resistant fusariosis in acute leukemia patients: report of two cases. (23076561)
2013
6
Tonsillitis with acute myeloid leukemia: a case series for caution. (23599112)
2013
7
Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia. (23077088)
2013
8
Aberrant Expression of CD13 Identifies a Subgroup of Standard-Risk Adult Acute Lymphoblastic Leukemia With Inferior Survival. (24411984)
2013
9
Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy. (22589484)
2012
10
Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia. (22728012)
2012
11
A novel gene LRP5 on 11q13.2 is rearranged in two patients with acute myeloid leukemia. (21821287)
2011
12
Distinct patterns of DNA damage response and apoptosis correlate with Jak/Stat and PI3kinase response profiles in human acute myelogenous leukemia. (20811632)
2010
13
FMS-like tyrosine kinase 3 gene mutation in acute myeloid leukemia detected by denaturing PAGE and its clinical significance]. (21176335)
2010
14
Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis. (20016533)
2010
15
CRLF2 and JAK2 in B-progenitor acute lymphoblastic leukemia: a novel association in oncogenesis. (20807819)
2010
16
Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias. (19901261)
2010
17
Acute leukemias with ETV6/ABL1 (TEL/ABL) fusion: poor prognosis and prenatal origin. (20589932)
2010
18
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. (20567020)
2010
19
Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. (19451432)
2009
20
The morphological subcategories of acute monocytic leukemia (M5a and M5b) share similar immunophenotypic and cytogenetic features and clinical outcomes. (17689610)
2008
21
Chronic meningitis by histoplasmosis: report of a child with acute myeloid leukemia. (19287853)
2008
22
Epigenetic and genetic analysis of the survivin promoter in acute myeloid leukemia. (18206228)
2008
23
Re: Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. (17596581)
2007
24
Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities. (17990177)
2007
25
RUNX1 amplification in lineage conversion of childhood B-cell acute lymphoblastic leukemia to acute myelogenous leukemia. (17889714)
2007
26
Angiogenesis factor pattern differs in acute lymphoblastic leukemia and chronic lymphocytic leukemia. (17654059)
2007
27
Studies of Wilms' Tumor (WT1) Gene Expression in Adult Acute Leukemias in Singapore. (19662212)
2007
28
Targeting receptor tyrosine kinase signaling in acute myeloid leukemia. (17658267)
2007
29
Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells. (17172412)
2006
30
Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease. (16113659)
2005
31
Marked reduction of LL-37/hCAP-18, an antimicrobial peptide, in patients with acute myeloid leukemia. (15717688)
2005
32
Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. (15956279)
2005
33
Expression of cyclin A in adult patients with acute leukemia]. (12887743)
2003
34
A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia. (12933575)
2003
35
Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin). (12200674)
2002
36
A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. (11468194)
2001
37
Total body irradiation, cyclophosphamide, and etoposide with stem cell transplant as treatment for infants with acute lymphocytic leukemia. (9917745)
1999
38
A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA-topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkylating agent, cyclophosphamide. (9631585)
1998
39
Frequent aberration of FHIT gene expression in acute leukemias. (9823330)
1998
40
V-J junctional sequences of T cell receptor gamma gene in acute lymphocytic leukemia. (7755873)
1995
41
Cytokine expression in adherent layers from patients with myelodysplastic syndrome and acute myelogenous leukemia. (7837815)
1995
42
Intermittent-dose ara-C/daunomycin therapy combined with cyclosporin-A and G-CSF led to a fourth remission in a patient with acute promyelocytic leukemia]. (7563610)
1995
43
Concurrent presence of inv(14)(q11q32) and t(4;11)(q21;q23) in pre-B acute lymphoblastic leukemia. (7536464)
1995
44
Allogeneic bone marrow transplantation for acute myelogenous leukemia, acute lymphocytic leukemia, and multiple myeloma following preparation with busulfan and cyclophosphamide (BuCy2). (8342074)
1993
45
Interferon system in primary acute lymphocytic leukemia cells with or without deletions of the alpha-/beta-interferon genes. (1562733)
1992
46
Treatment of acute non lymphoid leukemia (ANLL) in elderly patients. The GIMEMA experience. (1578948)
1992
47
Comparison of in vivo and in vitro effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with acute myeloid leukemia. (1587302)
1992
48
Interleukin-4 as a growth regulator of clonogenic cells in acute myelogenous leukemia in suspension culture. (1708433)
1991
49
Monitoring the unmaintained remission of acute non-lymphoblastic leukemia by serial bone marrow cultures. (1861533)
1991
50
Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16). (3180024)
1988

Genetic Variations for Acute Leukemia

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Expression for genes affiliated with Acute Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Leukemia

Search GEO for disease gene expression data for Acute Leukemia.

Pathways for genes affiliated with Acute Leukemia

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Acute Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3TCF3, TAF15, HOXA9, MPO, FLT3, WT1
211.0FLT3, DNTT, CD7, IL3RA
310.9TCF3, CDKN2B, FOXO3
410.9CDKN2B, DNTT, FOXO3

Compounds for genes affiliated with Acute Leukemia

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44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Acute Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.8MXD1, WT1, FLT3, MPO, MTHFR, DNTT
2etoposide44 49 59 1114.3WT1, FOXO3, FLT3, DNTT, TAL1
3thymidine44 2412.3WT1, FLT3, MTHFR, DNTT, IL3RA
4carboplatin44 49 1113.0DNTT, MTHFR, MPO
5naphthol as-d chloroacetate4410.9DNTT, MPO
6oligonucleotide4410.9TAL1, DNTT, FLT3, FOXO3, WT1
7cytarabine44 49 1112.8FLT3, MPO, CDKN2B
8nitro4410.8MPO, WT1
9gemtuzumab ozogamicin44 1111.8FLT3, WT1

GO Terms for genes affiliated with Acute Leukemia

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16Gene Ontology
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Cellular components related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.2ZNF384, WT1, FOXO3, MPO, PRAME, BAALC
2nucleolusGO:00573011.4BAALC, MKL1, DNTT, TAF15, MXD1, ZNF384

Biological processes related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635111.8FOXO3, PRAME, MKL1, CDKN2B, HOXA7, HOXA9
2positive regulation of transcription from RNA polymerase II promoterGO:04594411.5ZNF384, FOXO3, MKL1, CDKN2B, HOXA7, TAL1
3positive regulation of transcription, DNA-dependentGO:04589311.2WT1, FOXO3, TAL1, TAF15, TCF3
4positive regulation of erythrocyte differentiationGO:04564810.7TAL1, FOXO3
5megakaryocyte differentiationGO:03021910.7TAL1, CDKN2B
6definitive hemopoiesisGO:06021610.4TAL1, HOXA9

Molecular functions related to Acute Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356511.3ZNF384, TCF3, HOXA9, HOXA7, FOXO3, WT1
2sequence-specific DNA binding transcription factor activityGO:00370011.3TCF3, WT1, FOXO3, MKL1, HOXA7, HOXA9

Products for genes affiliated with Acute Leukemia

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Sources for Acute Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet