MCID: ACT134
MIFTS: 57

Acute Liver Failure malady

Liver diseases category

Summaries for Acute Liver Failure

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis and hepatitis a. An important gene associated with Acute Liver Failure is F2 (coagulation factor II (thrombin)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds d-galactosamine and 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Acute Liver Failure

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Sources:
30LifeMap Discovery™, 44Novoseek, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
acute liver failure:
Prevalence: 1-5/10000


Aliases & Descriptions:

acute liver failure 30 44 48
acute hepatic failure 48
liver failure, acute 60
liver failure acute 44


External Ids:

MESH via Orphanet35 D017114
ICD10 via Orphanet26 K72.0
SNOMED-CT via Orphanet57 197270009
UMLS via Orphanet61 C0162557

Related Diseases for Acute Liver Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Liver Disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3GPT, SLC17A5
2hepatitis a31.0F2
3wilson disease30.7OTC, SLC17A5, GPT
4hepatitis b30.7SLC17A5, F2, GPT, FGL2, AFP
5liver cirrhosis30.6HGF, AFP, GPT, F2, SLC17A5, TSPO
6herpes simplex30.6GC
7hepatitis e30.6GPT
8hepatic encephalopathy30.5GC, GPT, F2, SLC17A5, TSPO
9hypertension30.5F2
10autoimmune hepatitis30.5SEPSECS
11leukemia30.4CCL20, EIF2AK3, FST, OTC
12pancreatitis30.2SLC17A5
13acute pancreatitis30.2SLC17A5, GPT
14porphyria30.2ALAS1
15viral hepatitis30.2AFP, FGL2, GPT, F2, SLC17A5, SEPSECS
16endometriosis30.0FST, HGF, GC
17ischemia30.0HGF, EIF2AK3, FST, SLC17A5
18cholangiocarcinoma30.0HGF, AFP
19arthritis30.0CCL20, CD163
20tuberculosis30.0GC
21acute myocardial infarction30.0F7
22hepatic coma30.0F2, TSPO
23myocardial infarction30.0F7, CD163
24cholestasis30.0GPT, F2, SLC17A5
25portal hypertension30.0GPT, F2, SLC17A5
26alcoholic liver cirrhosis30.0SLC17A5, F2, GPT
27factor x deficiency30.0F7, F2
28alcoholic hepatitis30.0F2, HGF
29primary biliary cirrhosis30.0GPT, F2, SLC17A5, SEPSECS
30hepatitis c30.0AFP, GPT, F2, SLC17A5
31brain disease30.0GC, GPT, F2, SLC17A5, OTC, TSPO
32myopathy30.0SLC17A5, GPT, GK
33hepatocellular carcinoma30.0HGF, CCL20, AFP, F7, EIF2AK3, GPT
34brain edema10.7
35liver disease10.7
36cerebritis10.5
37acute kidney failure10.4
38liver failure acute infantile10.4
39liver lymphoma10.3
40acute leukemia10.3
41hemophagocytic lymphohistiocytosis10.3
42acute t cell leukemia10.3
43aplastic anemia10.3
44respiratory failure10.3
45t-cell leukemia10.3
46hypophosphatemia10.2
47adult t-cell leukemia10.2
48leptospirosis10.2
49polyarteritis nodosa10.2
50acute porphyria10.2

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to acute liver failure

Clinical Features for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Liver Failure

Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Search CenterWatch for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

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Anatomical Context for Acute Liver Failure

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Acute Liver Failure:

32
Liver, Brain, T cells, Kidney, Testes, Bone, Bone marrow, Breast, Endothelial, Heart, Lung, Monocytes, Nk cells, B cells, Pancreas, Skeletal muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Acute Liver Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.7GK, AFP, F7, FGL2, EIF2AK3, LECT2
2MP:00107689.4ALAS1, HGF, GK, AFP, F7, FGL2

Publications for Acute Liver Failure

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Sources:
50PubMed
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Articles related to Acute Liver Failure:

(show top 50)    (show all 716)
idTitleAuthorsYear
1
Management of acute liver failure in infants and children: consensus statement of the pediatric gastroenterology chapter, Indian academy of pediatrics. (23778727)
2013
2
Intraoperative predictors of short-term mortality in living donor liver transplantation due to acute liver failure. (23375307)
2013
3
Abdominal imaging can misdiagnose submassive hepatic necrosis as cirrhosis in acute liver failure. (23647426)
2013
4
Liver transplantation in a child with acute liver failure resulting from drug rash with eosinophilia and systemic symptoms syndrome. (23741237)
2013
5
Liver transplantation for acute liver failure caused by macrophage activation syndrome. (23981123)
2013
6
Perioperative risk factors for prolonged mechanical ventilation after liver transplantation due to acute liver failure. (24101957)
2013
7
Adrenal insufficiency as a cause of acute liver failure: a case report. (23533837)
2013
8
Lessons from look-back in acute liver failure? A single centre experience of 3300 patients. (23439263)
2013
9
Acute liver failure in under two year-olds--are there markers of metabolic disease on admission? (24018497)
2013
10
Efficacy of Various Combined Blood Purification Techniques for Treating Patients with Non-viral Acute Liver Failure. (24006155)
2013
11
Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure. (24164438)
2013
12
A case of acute liver failure due to etodolac. (22943552)
2013
13
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. (23758689)
2013
14
Urgent liver transplantation for nevirapine-induced acute liver failure: report of a case and review of the literature. (22466918)
2012
15
The evolving story of macrophages in acute liver failure. (22820147)
2012
16
Acute liver failure in Japan: definition, classification, and prediction of the outcome. (22825549)
2012
17
Predicting survival after living and deceased donor liver transplantation in adult patients with acute liver failure. (22526269)
2012
18
Liver transplantation for acute-on-chronic liver failure from erythropoietic protoporphyria. (23323258)
2012
19
Acute renal and liver failure due to acute fatty liver of pregnancy-complicated pre-eclampsia. (22943727)
2012
20
Liver transplantation for acute liver failure at 11-week gestation with successful maternal and fetal outcome. (23227416)
2012
21
Liver: determining prognosis in acute liver failure. (22392292)
2012
22
Case report of a successful liver transplantation for acute liver failure due to mitochondrial respiratory chain complex III deficiency. (22172894)
2011
23
Enhanced demethylation of interferon-I^ gene promoter in peripheral blood mononuclear cells is associated with acute-on-chronic hepatitis B liver failure. (21505270)
2011
24
Case records of the Massachusetts General Hospital. Case 12-2011. A 9-month-old boy with acute liver failure. (21506744)
2011
25
Acute liver failure. (21346565)
2011
26
Infectious complications in pediatric acute liver failure. (21555958)
2011
27
Dengue fever presenting as acute liver failure--a case report. (21771479)
2011
28
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. (21274877)
2011
29
Serum proinflammatory cytokines correlate with diffusion tensor imaging derived metrics and 1H-MR spectroscopy in patients with acute liver failure. (20838864)
2010
30
Stem cell mobilization is life saving in an animal model of acute liver failure. (20881764)
2010
31
Hyperdynamic circulation in acute liver failure: reperfusion syndrome and outcome following liver transplantation. (20534260)
2010
32
Analysis of prognostic factors for patients with acute-on-chronic liver failure]. (19719920)
2009
33
Imbalanced intrahepatic cytokine expression of interferon-gamma, tumor necrosis factor-alpha, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection. (18633332)
2009
34
MCP-1 and MIP3-alpha serum levels in acute liver failure and molecular adsorbent recirculating system (MARS) treatment: a pilot study. (19247846)
2009
35
Predictive criteria for the outcome of patients with acute liver failure treated with the albumin dialysis molecular adsorbent recirculating system. (19788457)
2009
36
Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay. (18507831)
2008
37
Rapid diagnosis of Wilson disease in acute liver failure: no more waiting for the ceruloplasmin level? (18821595)
2008
38
Quantitative multivoxel 1H MR spectroscopy of the brain in children with acute liver failure. (18493780)
2008
39
Improvement of impaired albumin binding capacity in acute-on-chronic liver failure by albumin dialysis. (18756471)
2008
40
Diagnostic criteria for acute liver failure due to Wilson disease. (17461475)
2007
41
Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine. (17900243)
2007
42
Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases. (17627974)
2007
43
Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure. (16530878)
2006
44
Use of albumin dialysis with the MARS device to treat a case acute liver failure after partial hepatic resection]. (15274801)
2004
45
Acute liver failure. Current aspects of diagnosis and therapy]. (15098097)
2004
46
Glycine conjugation of para-aminobenzoic acid (PABA): a pilot study of a novel prognostic test in acute liver failure in children. (12499998)
2003
47
Unusual peripheral T cell lymphoma presenting as acute liver failure and reappearing in the liver allograft. (11152113)
2000
48
Living related liver transplantation for acute liver failure in children. (10226105)
1999
49
Emergency liver transplantation for acute liver failure. Evaluation of London and Clichy criteria. (8445211)
1993
50
Acute renal failure in association with fatty liver of pregnancy. Recovery after fourteen days of complete anuria. (6024241)
1967

Genetic Variations for Acute Liver Failure

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Expression for genes affiliated with Acute Liver Failure

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

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Sources:
53Reactome, 49PharmGKB, 51QIAGEN, 37NCBI BioSystems Database
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Compounds for genes affiliated with Acute Liver Failure

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1d-galactosamine4410.7HGF, GPT, SLC17A5
25-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)1110.7F2, F7
3aminopyrine4410.7SLC17A5, GPT, F2
4hepaplastin4410.7GPT, SLC17A5, F2, HGF
5lamivudine44 1111.7F2, SLC17A5
6lidocaine44 28 1112.7HGF, TSPO, F2, SLC17A5
7ursodeoxycholic acid44 11 2412.7HGF, F2, GPT, SLC17A5
8levonorgestrel44 59 28 1113.7SLC17A5, F2, F7
9isoflurane44 1111.6GPT, TSPO, SLC17A5
10vitamin a44 11 2412.6GTF3A, HGF, GC, FST
11glutamate4410.6GPT, LECT2, OTC, TSPO
12pge14410.6SLC17A5, F2, GPT, HGF
13fatty acid4410.6HGF, OTC, SLC17A5, GK
14vitamin-e4410.6F7, EIF2AK3, GPT, SLC17A5, HGF
15phenobarbital44 28 1112.6TSPO, GPT, HGF, ALAS1, SLC17A5
165-hydroxytryptophol4410.6GPT, SLC17A5
17ccl444 2811.6CCL20, AFP, GPT, SLC17A5, HGF
18valproic acid44 49 11 2413.6GPT, TSPO, OTC, SLC17A5
19acetaminophen44 2 49 11 2414.6F2, AFP, HGF, GC, SLC17A5, GPT
20urea44 11 2412.6GC, OTC, SLC17A5, GPT, AFP
21glucose4410.6FST, GK, SLC17A5, OTC, GTF3A
22pyruvate4410.6HGF, SLC17A5, GPT, GK, OTC
23methotrexate44 49 1112.6GPT, HGF, AFP, F2, SLC17A5
24serine4410.6AFP, F7, FGL2, GTF3A, SEPSECS
25simvastatin44 49 59 28 11 2415.5AFP, GPT, F2, SLC17A5
26cyclosporin a44 28 5912.5HGF, TSPO, SEPSECS, SLC17A5, F2, GPT
27thyroxine44 2411.5AFP, GPT, SLC17A5, GC
28disulfiram44 59 1112.5GPT, TSPO, SLC17A5
29hyaluronic acid44 2411.5HGF, GPT, F2, SLC17A5
30phosphorus4410.5GC, GPT, SLC17A5
31alpha-hydroxybutyrate4410.5SLC17A5, GPT
32silymarin4410.5GPT, F2, SLC17A5
33glycogen44 2411.5OTC, SLC17A5, GPT, AFP, HGF
34lactate4410.5GPT, AFP, HGF, OTC, F2, FST
35iron44 2411.4AFP, CD163, GPT, SLC17A5, ALAS1, CCL20
36testosterone44 59 11 2413.4TSPO, SLC17A5, AFP, HGF, GC, FST
37fibrinogen4410.4FGL2, GC, F7, GTF3A, SLC17A5, F2
38glutamine4410.4HGF, AFP, EIF2AK3, GPT, LECT2, SLC17A5
39valproate4410.4GPT, SLC17A5, OTC
40aspartate4410.4HGF, SLC17A5, OTC, F2, GPT, EIF2AK3
41steroid4410.4FST, GTF3A, GC, TSPO, SEPSECS, AFP
42atp44 2811.4HGF, EIF2AK3, GK, FST, SLC17A5, OTC
43pyridoxal 5-phosphate4410.4SLC17A5, GPT, ALAS1
44lipid4410.3AFP, CD163, GC, F7, SLC17A5, OTC
45alanine4410.3EIF2AK3, HGF, CCL20, AFP, ALAS1, GPT
46creatinine4410.3FST, GC, HGF, AFP, GK, F7
47glycerol44 11 2412.2TSPO, OTC, GK, EIF2AK3
48Pyridoxal Phosphate1110.2SEPSECS, GPT, ALAS1
49nitric oxide44 11 2412.1FST, CCL20, EIF2AK3, SLC17A5, OTC, F7
50calcium44 49 11 2412.6CD163, F7, EIF2AK3, RGN, AFP, CCL20

GO Terms for genes affiliated with Acute Liver Failure

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Sources:
16Gene Ontology
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Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0HGF, CCL20, CD163, F7, F2, FST
2extracellular spaceGO:0056159.7F2, GC, HGF, CCL20, AFP, F7

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:03019410.4F2, F7
2anion transportGO:00682010.3TSPO, SLC17A5
3peptidyl-glutamic acid carboxylationGO:01718710.1F2, F7

Molecular functions related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.3ALAS1, SEPSECS, GPT

Products for genes affiliated with Acute Liver Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Liver Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet