MCID: ACT134
MIFTS: 54

Acute Liver Failure malady

Rare diseases, Liver diseases, Gastrointestinal diseases categories
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Summaries for Acute Liver Failure

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Wikipedia:65 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards based summary: Acute Liver Failure, also known as hepatic failure, acute, is related to hepatitis and hepatitis a. An important gene associated with Acute Liver Failure is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). The compounds hepaplastin and aminopyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Acute Liver Failure

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Sources:
30LifeMap Discovery®, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Acute Liver Failure, Aliases & Descriptions:

Name: Acute Liver Failure 30 44 48
Hepatic Failure, Acute 62
Acute Hepatic Failure 48
 
Liver Failure, Acute 62
Liver Failure Acute 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Liver diseases, Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
acute liver failure:
Prevalence: 1-5/10000


External Ids:

MESH via Orphanet35 D017114
ICD10 via Orphanet26 K72.0
UMLS via Orphanet63 C0162557

Related Diseases for Acute Liver Failure

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Diseases in the Liver Disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.6F2, SEPSECS, SLC17A5
2hepatitis a31.4F2
3hepatitis b31.1F2, SLC17A5
4autoimmune hepatitis30.8SLC17A5, SEPSECS, F2
5alcoholic hepatitis30.5F2, SLC17A5
6portal hypertension30.5F2, SLC17A5
7hepatic coma30.5TSPO, F2
8cholestasis30.4SLC17A5, F2
9hepatitis c30.3F2, SLC17A5
10viral hepatitis30.3SLC17A5, SEPSECS, F2
11primary biliary cirrhosis30.3SLC17A5, SEPSECS, F2
12hepatic encephalopathy29.8SLC17A5, GC, TSPO, AQP4, F2
13brain edema10.8
14cerebritis10.6
15wilson disease10.6
16liver disease10.5
17herpes simplex10.4
18choledocholithiasis10.4SLC17A5
19hepatitis e10.4
20liver failure acute infantile10.4
21spiradenoma10.4TSPO
22hypertension10.4
23leukemia10.4
24endotheliitis10.4
25aplastic anemia10.3
26hemophagocytic lymphohistiocytosis10.3
27cholangitis10.3SLC17A5, SEPSECS
2821-hydroxylase deficiency10.3SLC17A5, SEPSECS
29bilirubin metabolic disorder10.3F2, SLC17A5
30alcoholic liver cirrhosis10.2SLC17A5, F2
31adult t-cell leukemia10.2
32peripheral t-cell lymphoma10.2
33leptospirosis10.2
34adult-onset still's disease10.2
35polyarteritis nodosa10.2
36hypophosphatemia10.2
37amyloidosis10.2
38breast cancer10.2
39intracranial hypertension10.2
40lactic acidosis10.2
41pancreatitis10.2
42porphyria10.2
43t-cell leukemia10.2
44macrophage activation syndrome10.2
45neonatal herpes10.2
46patent ductus venosus10.2
47sepsis10.2
48leukopenia10.2SLC17A5, F2
49galactosemia10.2SLC17A5, F2
50stroke, ischemic10.1AQP4, F2

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to acute liver failure

Symptoms for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

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Anatomical Context for Acute Liver Failure

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MalaCards organs/tissues related to Acute Liver Failure:

32
Liver, Brain, Testes, Kidney, T cells, Neutrophil, Bone marrow, Bone, Breast, Endothelial, Heart, Lung, Monocytes, Pancreas, B cells, Skeletal muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

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MGI Mouse Phenotypes related to Acute Liver Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7SLC17A5, GC, AQP4, GK, F2

Publications for Acute Liver Failure

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Articles related to Acute Liver Failure:

(show top 50)    (show all 649)
idTitleAuthorsYear
1
Paracetamol-associated acute liver failure in Australian and New Zealand children: high rate of medication errors. (25228327)
2014
2
L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. (25258408)
2014
3
Management of acute liver failure in infants and children: consensus statement of the pediatric gastroenterology chapter, Indian academy of pediatrics. (23778727)
2013
4
TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. (23532086)
2013
5
Serum Testosterone Levels and Androgen Receptor CAG Polymorphism Correlate with Hepatitis B Virus (HBV)-Related Acute Liver Failure in Male HBV Carriers. (24391916)
2013
6
Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. (23489904)
2013
7
Letter: treatment of autoimmune acute liver failure--beyond consensus guidelines; author's reply. (24099481)
2013
8
Radiologic and Histologic Heterogeneity in a Case of AutoimmuneA Acute Liver Failure. (23962551)
2013
9
Acute liver failure associated with levetiracetam and lacosamide combination treatment for unspecified epileptic disorder. (24027645)
2013
10
Intraoperative predictors of short-term mortality in living donor liver transplantation due to acute liver failure. (23375307)
2013
11
Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. (24164805)
2013
12
Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. (23166746)
2012
13
Lipopolysaccharide binding protein is down-regulated during acute liver failure. (22278340)
2012
14
Neurological complications of acute liver failure: pathophysiological basis of current management and emerging therapies. (22100567)
2012
15
Neutrophil CD64 expression is elevated in acetaminophen-induced acute liver failure. (23155217)
2012
16
Urgent liver transplantation for nevirapine-induced acute liver failure: report of a case and review of the literature. (22466918)
2012
17
Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats. (22535497)
2012
18
Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia. (22171136)
2011
19
Assessment of emergency liver transplantation criteria in acute liver failure due to Amanita phalloides. (21960294)
2011
20
Effects of intraperitoneal albumin on systemic and cerebral hemodynamics in a swine model of acute liver failure. (21524179)
2011
21
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
22
Early myocardial injury is an integral component of experimental acute liver failure - a study in two porcine models. (22291759)
2011
23
Invasive versus noninvasive intracranial pressure monitoring in children with acute liver failure. (22067827)
2011
24
Metastatic breast cancer presenting as acute liver failure. (21346858)
2011
25
Bridging therapies and liver transplantation in acute liver failure, 10 years of MARS experience from Finland. (21482500)
2011
26
Case report of a successful liver transplantation for acute liver failure due to mitochondrial respiratory chain complex III deficiency. (22172894)
2011
27
Acute liver failure in neonates, infants and children. (22017699)
2011
28
Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. (21499580)
2011
29
A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review. (21103229)
2010
30
Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)
2010
31
Serum proinflammatory cytokines correlate with diffusion tensor imaging derived metrics and 1H-MR spectroscopy in patients with acute liver failure. (20838864)
2010
32
Drug-induced acute liver failure and gastrointestinal complications. (20502172)
2010
33
Alternative transplant procedures for acute liver failure. (21086942)
2010
34
Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation. (21168638)
2010
35
Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure. (19505222)
2009
36
Sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure. (19954554)
2009
37
A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure. (19590182)
2009
38
De novo mutations in POLG presenting with acute liver failure or encephalopathy. (19252446)
2009
39
Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case. (18609519)
2008
40
Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. (18161828)
2008
41
Effects of granulocyte colony-stimulating factor on hepatocyte apoptosis in acute liver failure: experiment with rats]. (18756972)
2008
42
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
43
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. (17185352)
2007
44
Efficacy and safety of coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration for multiple organ dysfunction syndrome patients with acute liver failure]. (17207366)
2007
45
Caspase 8 small interfering RNA prevents acute liver failure in mice. (12810955)
2003
46
Glycine conjugation of para-aminobenzoic acid (PABA): a pilot study of a novel prognostic test in acute liver failure in children. (12499998)
2003
47
Living related liver transplantation for acute liver failure in children. (10226105)
1999
48
Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)
1997
49
Acute liver failure as the initial manifestation of Wilson disease]. (7565403)
1995
50
Does hypophosphatemia play a role in acute liver failure? (2921001)
1989

Variations for Acute Liver Failure

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Expression for genes affiliated with Acute Liver Failure

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Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

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Compounds for genes affiliated with Acute Liver Failure

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Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1hepaplastin4410.1SLC17A5, F2
2aminopyrine4410.1SLC17A5, F2
3antipyrine44 1111.0SLC17A5, F2
4levonorgestrel44 61 28 1113.0F2, SLC17A5
5amiodarone44 50 28 1113.0SLC17A5, F2
6lamivudine44 50 1112.0SLC17A5, F2
7digoxin44 61 50 24 1114.0SLC17A5, F2
8ursodeoxycholic acid44 24 1112.0SLC17A5, F2
9penicillin4410.0TSPO, F2
10halothane44 50 28 1113.0SEPSECS, SLC17A5
11silymarin4410.0SLC17A5, F2
12dipyridamole44 61 28 1112.9TSPO, F2
13thiamine44 2 24 1112.9TSPO, SLC17A5
14isoflurane50 44 1111.9SLC17A5, TSPO
15pge1449.9SLC17A5, F2
16aprotinin44 1110.8F2, SLC17A5
17disulfiram44 50 61 1112.8SLC17A5, TSPO
18phenytoin44 50 28 1112.8TSPO, SLC17A5
19polyethylene glycol449.8SLC17A5, F2
20carbamazepine44 50 1111.8TSPO, SLC17A5
21opiate449.8TSPO, SLC17A5
22benzodiazepine449.7TSPO, GK
23phenobarbital44 28 50 1112.7SLC17A5, TSPO
24lidocaine44 28 1111.6F2, TSPO, SLC17A5
25phosphorus449.5GC, SLC17A5
26valproic acid44 50 24 1112.5SLC17A5, TSPO
27rosiglitazone28 44 50 24 1113.4SLC17A5, GK
28morphine44 50 28 1112.4TSPO, SLC17A5
29chloride449.4AQP4, TSPO, SLC17A5
30bicarbonate449.4GC, AQP4
31acetaminophen44 2 50 24 1113.3SLC17A5, GC, F2
32norepinephrine44 24 1111.2GK, TSPO, SLC17A5
33glycerol44 24 1111.2TSPO, AQP4, GK
34cyclosporin a44 28 6111.2F2, SEPSECS, TSPO, SLC17A5
35fibrinogen449.2F2, GC, SLC17A5
36urea44 24 1111.1AQP4, GC, SLC17A5
37aspartate449.1SLC17A5, GC, F2
38h2o2449.0GK, TSPO, SLC17A5
39fatty acid448.9SLC17A5, GC, GK
40testosterone44 61 24 1111.7SLC17A5, GC, TSPO
41glutamate448.6AQP4, TSPO, GC, SLC17A5
42steroid448.5GC, TSPO, SEPSECS
43creatinine448.1SLC17A5, GC, TSPO, GK, F2

GO Terms for genes affiliated with Acute Liver Failure

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Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.3TSPO, GK

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anion transportGO:0068209.4SLC17A5, TSPO
2positive regulation of reactive oxygen species metabolic processGO:20003799.3TSPO, F2
3steroid metabolic processGO:0082029.1GC, TSPO

Molecular functions related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tRNA bindingGO:0000499.7TRMU, SEPSECS

Products for genes affiliated with Acute Liver Failure

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Sources for Acute Liver Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet