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MCID: ACT134

Acute Liver Failure malady
20 genes, 4 tissues, 118 related diseases, clinical trials.

Summaries for Acute Liver Failure

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59Wikipedia, 29MalaCards
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Wikipedia:59 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis and wilson disease. An important gene associated with Acute Liver Failure is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways is FOXA2 and FOXA3 transcription factor networks. The compounds lamivudine and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and liver, and related mouse phenotype mortality/aging.

Aliases & Classifications for Acute Liver Failure

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41Novoseek, 45Orphanet, 28LifeMap Discovery™, 56UMLS, 32MESH via Orphanet, 24ICD10 via Orphanet, 53SNOMED-CT via Orphanet, 57UMLS via Orphanet
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Aliases & Descriptions:

acute liver failure 41 45 28
acute hepatic failure 45
liver failure, acute 56

Classifications:


ICD10: 24


External Ids:

MESH via Orphanet32 D017114
ICD10 via Orphanet24 K72.0
SNOMED-CT via Orphanet53 197270009
UMLS via Orphanet57 C0162557

Related Diseases for Acute Liver Failure

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16GeneCards, 17GeneDecks
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Diseases related to acute liver failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.7SLC17A5, GPT
2wilson disease32.0GPT, SLC17A5
3hepatitis a30.4F2
4ischemia30.2SLC17A5, FST, HGF
5hepatitis e30.2GPT
6endometriosis30.1GC, HGF, FST
7herpes simplex30.1GC, POLG
8myocardial infarction30.0HGF, CD163, F7
9hepatitis b30.0SLC17A5, FGL2, GPT, AFP, F2
10primary biliary cirrhosis30.0SLC17A5, SEPSECS, GPT, F2
11peritonitis13.9F2
12blindness13.9TSPO
13hypertension13.9F2
14inflammatory bowel disease13.9CCL20
15pancreatitis13.9SLC17A5
16sclerosing cholangitis13.9SEPSECS
17colorectal cancer13.9HGF
18acute myocardial infarction13.9F7
19lactic acidosis13.9POLG
20meningitis13.8FST
21autoimmune hepatitis13.8SEPSECS
22coronary heart disease13.8F7
23purpura13.8THPO
24thromboembolism13.8F7, F2
25arthritis13.8CCL20, CD163
26chronic myeloproliferative disease13.8THPO
27cerebral infarction13.8TSPO
28endocarditis13.8GTF3A
29atherosclerosis13.8F7, FST
30glanzmann's thrombasthenia13.8F7
31biliary atresia13.8GPT, HGF
32iron overload, autosomal dominant13.8GPT, SLC17A5
33deep vein thrombosis13.8F2
34kawasaki disease13.8GPT
35sarcoma13.8CD163, THPO
36cryoglobulinemia13.8SLC17A5
37acute pancreatitis13.8GPT, SLC17A5
38cholangiocarcinoma13.8AFP, HGF
39factor v deficiency13.8F2
40cholelithiasis13.8GPT
41hepatic coma13.8TSPO, F2
42alcoholism13.7GPT, SLC17A5, TSPO
43esophageal varix13.7F2
44chondrodysplasia punctata 1, x-linked13.7AFP, F2
45disseminated intravascular coagulation13.7F7, F2, THPO
46pyridoxine deficiency13.7SLC17A5, GPT
47cystic fibrosis13.7CCL20, GC
48ipex syndrome13.7GTF3A, GPT, THPO
49cholestasis13.7F2, GPT, SLC17A5
50bilirubin metabolic disorder13.7SLC17A5, GPT, F2

Graphical network of the top 20 diseases related to acute liver failure:



Diseases related to acute liver failure

Symptoms for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 28LifeMap Discovery™, 56UMLS, 37NDF-RT
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Approved drugs:

Search CenterWatch for acute liver failure

Drug clinical trials:

Search ClinicalTrials for acute liver failure

Search NIH Clinical Center for acute liver failure

Search CenterWatch for acute liver failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for acute liver failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to acute liver failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

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Anatomical Context for Acute Liver Failure

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28LifeMap Discovery™, 29MalaCards
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MalaCards organs/tissues related to acute liver failure:

29
Brain, Liver, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to acute liver failure:
id Tissue -> Anatomical Compartment -> Cell Relevance
1 Liver -> Liver Lobule -> Hepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to acute liver failure:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
mortality/aging
MP:00107689.7F7, SLC17A5, GK, FGL2, FST, HGF

Publications for Acute Liver Failure

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47PubMed
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Articles related to acute liver failure:

(show top 50)    (show all 103)
idTitleAuthorsYearAffiliating Genes
1Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population. (22727021)Yan Z.... Deng G.2012ESR1
2Acetaminophen induced acute liver failure via oxidati ve stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. (20166895)Das J.... Sil P.C.2010CYP2E1
3Regulatory polymorphisms in the IL-10 gene promoter and HBV-related acute liver failure in the Chinese population. (19413695)Yan Z.... Deng G.2009IL10
4Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. (19439490)James L.P.... Lee W.M.2009F2
5Acute liver failure: managing coagulopathy and the bl eeding diathesis. (19460532)De Gasperi A.... Bettinelli L.2009F2
6A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure. (19590182)Karvellas C.J.... Gibney R.T.2009ALB
7De novo mutations in POLG presenting with acute liver failure or encephalopathy. (19252446)Lutz R.E.... Wong L.J.2009POLG
8MCP-1 and MIP3-alpha serum levels in acute liver failure and molecular adsorbent recirculating system (MARS) treatment: a pilot study. (19247846)Roth G.A.... Krenn C.G.2009CCL20
9Early treatment with N-acetylcysteine in children wit h acute liver failure secondary to hepatitis A. (20009135)Sotelo N.... Dhanakotti N.2009F2, F3, GPT
10Recurrent acute liver failure and mitochondriopathy in a case of Wolcott-Rallison syndrome. (18704764)Engelmann G.... Buchanan C.R.2008EIF2AK3
11Cytokine profiles in acute liver failure treated with albumin dialysis. (18181803)Ilonen I.... Isoniemi H.2008ALB
12The coagulopathy of acute liver failure and implications for intracranial pressure monitoring. (18379899)Munoz S.J.... Lee W.2008F2
13Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure. (19017995)Han C.... Wu T.2008PTGS2
14Prognostic factors in paediatric acute liver failure. (17872939)Ciocca M.... Alvarez F.2008F2
15Acute liver failure in pregnancy associated with maternal MCAD deficiency. (17186412)Santos L.... Henderson M.2007ACADM
16Diagnostic criteria for acute liver failure due to Wilson disease. (17461475)Eisenbach C.... Merle U.2007SLC17A5
17The significance of autoantibodies and immunoglobulin s in acute liver failure: a cohort study. (17602781)Bernal W.... Vergani D.2007SEPSECS
18Acute liver failure due to leptospirosis successfully treated with MARS (molecular adsorbent recirculating system) dialysis. (17203354)Covic A.... Gusbeth-Tatomir P.2007ALB
19Predictive value of actin-free Gc-globulin in acute liver failure. (17763387)Schiodt F.V.... Lee W.M.2007GC
20Identification of novel molecular candidates for acute liver failure in plasma of BALB/c murine model. (17569552)Lv S.... Liu F.2007RGN, PEBP1
21Actin-free Gc globulin: a rapidly assessed biomarker of organ dysfunction in acute liver failure and cirrhosis. (17763400)Antoniades C.G.... Vergani D.2007GC
22Predicting outcome in acute liver failure: are we there yet? (17763397)Macquillan G.2007GC
23Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases. (17627974)Barnes S.N.... Manautou J.E.2007ABCC1, ABCC4, ABCC5
24Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice. (17525263)Le Minh K.... Vollmar B.2007EPO
25A bolt out of the blue: a case of unexpected acute liver failure. (16902729)Wong R.K.... Wai C.T.2006SLC17A5
26Alpha-fetoprotein and prognosis in acute liver failure. (17133565)Schiodt F.V.... Lee W.M.2006AFP
27Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation. (16941171)Camus C.... Thomas R.2006F2
28Molecular characterization of hepatitis E virus in three acute liver failure cases in children in Argentina (17407988)Munne M.S.... Gonzalez J.E.2006SPARCL1
29The acidifying effect of lactate is neutralized by the alkalinizing effect of hypoalbuminemia in non-paracetamol-induced acute liver failure. (16750869)Funk G.C.... Schneeweiss B.2006ALB
30Ornithine transcarbamoylase deficiency presenting with acute liver failure. (16802108)Mustafa A.... Clarke J.T.2006OTC
31Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. (16737880)Squires R.H.... Hynan L.S.2006F2
32One hundred sixteen cases of acute liver failure treated with MARS. (16182742)Novelli G.... Berloco P.B.2005ALB
33The effect of albumin dialysis on cytokine levels in acute liver failure and need for liver transplantation. (15848631)Isoniemi H.... HAPckerstedt K.2005ALB
34Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure. (15826719)BAclanger M.... Butterworth R.F.2005TSPO
35Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. (15956233)Vanderperren B.... Hantson P.2005F2
36A case of acute liver failure caused by herpes simplex type 2. (15307595)Boysen T.... Clausen M.R.2004MBL2
37Albumin dialysis MARS (Molecular Adsorbent Recirculating System) as a bridge for liver transplantation in acute liver failure. Report of three cases (15279147)Contreras J.... DA-az J.C.2004ALB
38Phosphorus ans an early predictive factor in patients with acute liver failure. (12829902)Baquerizo A.... Busuttil R.W.2003F2
39MARS (Molecular Adsorbent Recirculating System): experience in 34 cases of acute liver failure. (12220303)Novelli G.... Cortesini R.2002ALB
40Acute liver failure: clinical-epidemiological characteristics (11873665)Bosia J.D.... Curciarello J.O.2001F2
41Alterations in expression of genes coding for key astrocytic proteins in acute liver failure. (11746425)Desjardins P.... Butterworth R.F.2001SLC1A2, GFAP, TSPO
42Acute liver failure due to enalapril. (11141678)Jeserich M.... Heilmann C.2000CALR
43Hepatic expression of hepatocyte growth factor gene mRNA in acute liver failure. (11117560)Harrison P.... Bomford A.2000HGF
44Carbohydrate 19-9 antigen as a marker of non-malignant hepatocytic ductular transformation in patients with acute liver failure. A comparison with alpha-fetoprotein and carcinoembryonic antigen. (10365905)Halme L.... HAPckerstedt K.1999AFP
45L-ornithine-L-aspartate lowers plasma and cerebrospin al fluid ammonia and prevents brain edema in rats with acute liver failure. (10462368)Rose C.... Butterworth R.F.1999GLUL
46Earlier identification of patients at risk from aceta minophen-induced acute liver failure. (9468165)Mitchell I.... Williams R.1998F2
47Halothane-induced acute liver failure: continuing occurrence and use of liver transplantation. (9744690)Lo S.K.... Williams R.1998F2
48Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)Suhler E.... Lee W.M.1997GSN
49Acute liver failure as the initial manifestation of Wilson disease (7565403)Herrmann S.... Theilmann L.1995SLC17A5
50Acute liver failure: current hepatological-surgical therapy strategies (1376483)Maier K.P.1992F2

Variations for Acute Liver Failure

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Expression for genes affiliated with Acute Liver Failure

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Pathways for genes affiliated with Acute Liver Failure

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34NCBI BioSystems Database
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Pathways related to acute liver failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
FOXA2 and FOXA3 transcription factor networks34
10.3F2, ALAS1, AFP

Compounds for genes affiliated with Acute Liver Failure

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41Novoseek, 11DrugBank, 22HMDB, 46PharmGKB, 55Tocris Bioscience, 2BitterDB
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Compounds related to acute liver failure according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1lamivudine41 1111.9POLG
2heparin41 11 2212.7SLC17A5
35-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)1110.7F7, F2
4d-galactosamine4110.7HGF, GPT, SLC17A5
5aminopyrine4110.7F2, GPT, SLC17A5
6hepaplastin4110.7SLC17A5, GPT, HGF, F2
7nevirapine41 46 1112.7POLG, SLC17A5, GPT
8lidocaine41 1111.6TSPO, SLC17A5, HGF, F2
9disulfiram41 55 1112.6TSPO, SLC17A5, GPT
10glutamine4110.6TSPO, HGF, LECT2, POLG
11ursodeoxycholic acid41 11 2212.6GPT, F2, HGF, SLC17A5
12pge14110.6HGF, F2, GPT, SLC17A5
13levonorgestrel41 1111.6F7, F2, SLC17A5
14polyethylene glycol4110.6THPO, AFP, SLC17A5, F2
15isoflurane41 1111.6GPT, TSPO, SLC17A5
16vitamin-e4110.6HGF, F7, GPT, SLC17A5
17phenobarbital41 1111.6HGF, ALAS1, GPT, TSPO, SLC17A5
18ccl44110.6SLC17A5, GPT, CCL20, HGF, AFP
19hyaluronic acid41 2211.6SLC17A5, GPT, HGF, F2, THPO
20methotrexate41 46 55 1113.5HGF, AFP, GPT, SLC17A5, F2
21acetaminophen41 46 2 11 2214.5SLC17A5, HGF, GPT, AFP, F2, GC
225-hydroxytryptophol4110.5SLC17A5, GPT
23cyclosporin a41 5511.5HGF, F2, GPT, SEPSECS, SLC17A5, TSPO
24agar4110.5FST, HGF, TSPO, THPO, AFP
25urea41 11 2212.5GPT, SLC17A5, AFP, GC
26vitamin a41 11 2212.5GC, SLC17A5, GTF3A, FST, GPT, HGF
27sialic acid4110.5AFP, SLC17A5, GC, THPO
28simvastatin41 46 55 11 2214.5F2, AFP, GPT, SLC17A5
29thymidine41 2211.5AFP, HGF, FST, POLG, GTF3A
30aspartate4110.4F7, F2, GC, SLC17A5, GPT, HGF
31alanine4110.4CCL20, POLG, F2, GTF3A, AFP, ALAS1
32tgf beta14110.4AFP, FST, THPO, HGF
33hirudin4110.4FGL2, F2, THPO
34steroid4110.4FST, GC, AFP, GTF3A, SEPSECS, TSPO
35lactate4110.4FST, SLC17A5, POLG, GPT, THPO, HGF
36adenylate4110.4POLG, GPT, GC, HGF, FST, THPO
37iron41 2211.3CD163, GPT, THPO, SLC17A5, AFP, CCL20
38glutamate4110.3SLC17A5, TSPO, AFP, GPT, HGF, GC
39h2o24110.3THPO, GK, HGF, AFP, SLC17A5, TSPO
40fibrinogen4110.3GC, F7, AFP, GTF3A, GPT, FGL2
41phosphorus4110.3GC, GPT, SLC17A5
42thyroxine41 2211.3GC, SLC17A5, GPT, AFP
43glucose4110.3GC, GTF3A, GPT, GK, FST, SLC17A5
44lipid4110.2SLC17A5, CD163, HGF, GPT, GK, F7
45creatinine4110.2GK, TSPO, SLC17A5, GPT, FST, HGF
46serine4110.2FGL2, FST, GTF3A, F2, HGF, SEPSECS
47estrogen4110.2TSPO, HGF, F2, GC, FST, THPO
48alpha-hydroxybutyrate4110.0GPT, SLC17A5
49atp4110.0POLG, THPO, GK, FST, GTF3A, SLC17A5
50testosterone41 11 2212.0TSPO, AFP, SLC17A5, FST, HGF, GC

GO Terms for genes affiliated with Acute Liver Failure

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15Gene Ontology
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Cellular components related to acute liver failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.9F7, F2, LECT2, GC, CCL20, AFP

Biological processes related to acute liver failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:01718710.3F7, F2
2anion transportGO:00682010.2SLC17A5, TSPO
3positive regulation of blood coagulationGO:03019410.0F7, F2

Molecular functions related to acute liver failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.3ALAS1, GPT, SEPSECS

Products for genes affiliated with Acute Liver Failure

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  • Antibodies
  • Proteins
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Sources for Acute Liver Failure

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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