MCID: ACT134
MIFTS: 57

Acute Liver Failure malady

Liver diseases category

Summaries for Acute Liver Failure

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis and hepatitis a. An important gene associated with Acute Liver Failure is F2 (coagulation factor II (thrombin)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds d-galactosamine and 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Acute Liver Failure

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Sources:
30LifeMap Discovery™, 44Novoseek, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
acute liver failure:
Prevalence: 1-5/10000


Aliases & Descriptions:

acute liver failure 30 44 48
acute hepatic failure 48
liver failure, acute 60
liver failure acute 44


External Ids:

MESH via Orphanet35 D017114
ICD10 via Orphanet26 K72.0
SNOMED-CT via Orphanet57 197270009
UMLS via Orphanet61 C0162557

Related Diseases for Acute Liver Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Liver Disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3GPT, SLC17A5
2hepatitis a31.0F2
3wilson disease30.7OTC, SLC17A5, GPT
4hepatitis b30.7SLC17A5, F2, GPT, FGL2, AFP
5liver cirrhosis30.6HGF, AFP, GPT, F2, SLC17A5, TSPO
6herpes simplex30.6GC
7hepatitis e30.6GPT
8hepatic encephalopathy30.5GC, GPT, F2, SLC17A5, TSPO
9hypertension30.5F2
10autoimmune hepatitis30.5SEPSECS
11leukemia30.4CCL20, EIF2AK3, FST, OTC
12pancreatitis30.2SLC17A5
13acute pancreatitis30.2SLC17A5, GPT
14porphyria30.2ALAS1
15viral hepatitis30.2AFP, FGL2, GPT, F2, SLC17A5, SEPSECS
16endometriosis30.0FST, HGF, GC
17ischemia30.0HGF, EIF2AK3, FST, SLC17A5
18cholangiocarcinoma30.0HGF, AFP
19arthritis30.0CCL20, CD163
20tuberculosis30.0GC
21acute myocardial infarction30.0F7
22hepatic coma30.0F2, TSPO
23myocardial infarction30.0F7, CD163
24cholestasis30.0GPT, F2, SLC17A5
25portal hypertension30.0GPT, F2, SLC17A5
26alcoholic liver cirrhosis30.0SLC17A5, F2, GPT
27factor x deficiency30.0F7, F2
28alcoholic hepatitis30.0F2, HGF
29primary biliary cirrhosis30.0GPT, F2, SLC17A5, SEPSECS
30hepatitis c30.0AFP, GPT, F2, SLC17A5
31brain disease30.0GC, GPT, F2, SLC17A5, OTC, TSPO
32myopathy30.0SLC17A5, GPT, GK
33hepatocellular carcinoma30.0HGF, CCL20, AFP, F7, EIF2AK3, GPT
34brain edema10.7
35liver disease10.7
36cerebritis10.5
37acute kidney failure10.4
38liver failure acute infantile10.4
39liver lymphoma10.3
40acute leukemia10.3
41hemophagocytic lymphohistiocytosis10.3
42acute t cell leukemia10.3
43aplastic anemia10.3
44respiratory failure10.3
45t-cell leukemia10.3
46hypophosphatemia10.2
47adult t-cell leukemia10.2
48leptospirosis10.2
49polyarteritis nodosa10.2
50acute porphyria10.2

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to acute liver failure

Clinical Features for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Liver Failure

Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Search CenterWatch for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

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Anatomical Context for Acute Liver Failure

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Acute Liver Failure:

32
Liver, Brain, T cells, Kidney, Testes, Bone, Breast, Bone marrow, Endothelial, Heart, Monocytes, Lung, Pancreas, B cells, Nk cells, Skeletal muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Acute Liver Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.7GK, AFP, F7, FGL2, EIF2AK3, LECT2
2MP:00107689.4ALAS1, HGF, GK, AFP, F7, FGL2

Publications for Acute Liver Failure

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Sources:
50PubMed
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Articles related to Acute Liver Failure:

(show top 50)    (show all 716)
idTitleAuthorsYear
1
Elevated expression of tumour necrosis factor-I+-induced protein 8 (TNFAIP8)-like 2 mRNA in peripheral blood mononuclear cells is associated with disease progression of acute-on-chronic hepatitis B liver failure. (24329858)
2014
2
Living donor liver transplant in pediatric acute liver failure: an important option, but when do we use it? (24385021)
2014
3
Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure. (24321433)
2014
4
Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure. (24104197)
2014
5
Acute Liver Failure Associated With Traditional Chinese Medicine: Report of 30 Cases From Seven Tertiary Hospitals in China. (24335449)
2014
6
TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. (23532086)
2013
7
Serum Testosterone Levels and Androgen Receptor CAG Polymorphism Correlate with Hepatitis B Virus (HBV)-Related Acute Liver Failure in Male HBV Carriers. (24391916)
2013
8
Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. (23489904)
2013
9
Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure. (23215950)
2013
10
Acute liver failure. (24160932)
2013
11
Use of acetylcysteine for non-acetaminophen-induced acute liver failure. (23293188)
2013
12
Molecular Adsorbent Recirculating System (MARS(Ar)) removal of piperacillin/tazobactam in a patient with acetaminophen-induced acute liver failure. (23279615)
2013
13
Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival. (23782487)
2013
14
Predicting the prognosis in acute liver failure: results from a retrospective pilot study using the LiMAx test. (23813133)
2013
15
Etiology and prognostic factors of acute liver failure in children. (23255683)
2013
16
Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model. (23498809)
2013
17
Causality of Drugs Involved in Acute Liver Failure Leading to Transplantation: Results from the Study of Acute Liver Transplant (SALT). (23743692)
2013
18
Posterior reversible encephalopathy syndrome in a survivor of valproate-induced acute liver failure: a case report. (23724918)
2013
19
Should N-acetylcysteine be used in treatment of non-acetaminophen pediatric acute liver failure? (24222292)
2013
20
GABAergic neurosteroids: the "endogenous benzodiazepines" of acute liver failure. (22041164)
2012
21
Acute liver failure in children: 20-year experience. (22706740)
2012
22
Algorithm to determine the outcome of patients with acute liver failure: a data-mining analysis using decision trees. (22402772)
2012
23
Hodgkin disease relapse discovered at the time of liver transplant for acute liver failure. (21054714)
2012
24
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. (22532075)
2012
25
Correlation of the intracranial pressure to the central venous pressure in the late phase of acute liver failure in a porcine model. (22327729)
2012
26
Recent developments in acute liver failure. (22482521)
2012
27
Increased mortality from acute liver failure in Mexico. (22345344)
2012
28
Early myocardial injury is an integral component of experimental acute liver failure - a study in two porcine models. (22291759)
2011
29
Invasive versus noninvasive intracranial pressure monitoring in children with acute liver failure. (22067827)
2011
30
Acute liver failure in children. (21531191)
2011
31
Expression of COX-2 and PPARg in the livers of patients with acute on chronic HBV-related liver failure and their relationship with clinic parameters]. (22152242)
2011
32
Transplantation of encapsulated hepatocytes during acute liver failure improves survival without stimulating native liver regeneration. (21396154)
2011
33
Acute liver failure after recommended doses of acetaminophen in patients with myopathies. (21242792)
2011
34
HMGB1 cytoplasmic translocation in patients with acute liver failure. (21406085)
2011
35
A Src family kinase inhibitor improves survival in experimental acute liver failure associated with elevated cerebral and circulating vascular endothelial growth factor levels. (21745297)
2011
36
Transplantation of immortalized human fetal hepatocytes prevents acute liver failure in 90% hepatectomized mice. (20620547)
2010
37
Acute liver failure secondary to gemcitabine. (22736319)
2010
38
Echocardiographic diagnosis of systemic AA amyloidosis presenting with acute liver failure. (20821940)
2010
39
Acute liver failure associated with rubella virus in a child. (20228694)
2010
40
Acute-on-chronic liver failure due to thiamazole in a patient with hyperthyroidism and trilogy of Fallot: case report. (20707932)
2010
41
Intensive care management of children with acute liver failure. (20799075)
2010
42
Cytokine and autoantibody patterns in acute liver failure. (20039781)
2010
43
Acute liver failure: managing coagulopathy and the bleeding diathesis. (19460532)
2009
44
Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case. (18609519)
2008
45
Effects of granulocyte colony-stimulating factor on hepatocyte apoptosis in acute liver failure: experiment with rats]. (18756972)
2008
46
Prevention and management of brain edema in patients with acute liver failure. (18825686)
2008
47
Evolution of hepatorenal syndrome after orthotopic liver transplantation: comparative analysis with patients who developed acute renal failure in the early postoperative period of liver transplantation. (17889176)
2007
48
Alpha-fetoprotein and prognosis in acute liver failure. (17133565)
2006
49
Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. (16737880)
2006
50
Increased heme oxygenase-1 and decreased delta-aminolevulinate synthase expression in the liver of patients with acute liver failure. (15547665)
2004

Genetic Variations for Acute Liver Failure

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Expression for genes affiliated with Acute Liver Failure

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

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Sources:
53Reactome, 49PharmGKB, 51QIAGEN, 37NCBI BioSystems Database
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Compounds for genes affiliated with Acute Liver Failure

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1d-galactosamine4410.7HGF, GPT, SLC17A5
25-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)1110.7F2, F7
3aminopyrine4410.7GPT, F2, SLC17A5
4hepaplastin4410.7HGF, GPT, F2, SLC17A5
5lamivudine44 1111.7SLC17A5, F2
6lidocaine44 28 1112.7TSPO, SLC17A5, F2, HGF
7ursodeoxycholic acid44 11 2412.7HGF, GPT, F2, SLC17A5
8levonorgestrel44 59 28 1113.7F7, F2, SLC17A5
9isoflurane44 1111.6TSPO, SLC17A5, GPT
10vitamin a44 11 2412.6GC, HGF, FST, GTF3A
11glutamate4410.6GPT, LECT2, OTC, TSPO
12pge14410.6HGF, GPT, F2, SLC17A5
13fatty acid4410.6OTC, SLC17A5, GK, HGF
14vitamin-e4410.6HGF, F7, EIF2AK3, GPT, SLC17A5
15phenobarbital44 28 1112.6ALAS1, TSPO, SLC17A5, GPT, HGF
165-hydroxytryptophol4410.6SLC17A5, GPT
17ccl444 2811.6HGF, CCL20, AFP, GPT, SLC17A5
18valproic acid44 49 11 2413.6TSPO, OTC, SLC17A5, GPT
19acetaminophen44 2 49 11 2414.6GC, HGF, AFP, GPT, F2, SLC17A5
20urea44 11 2412.6GC, AFP, GPT, SLC17A5, OTC
21glucose4410.6GK, FST, SLC17A5, OTC, GTF3A
22pyruvate4410.6OTC, SLC17A5, GPT, GK, HGF
23methotrexate44 49 1112.6HGF, AFP, GPT, F2, SLC17A5
24serine4410.6GTF3A, SEPSECS, FGL2, F7, AFP
25simvastatin44 49 59 28 11 2415.5SLC17A5, F2, GPT, AFP
26cyclosporin a44 28 5912.5HGF, GPT, F2, SLC17A5, SEPSECS, TSPO
27thyroxine44 2411.5GC, AFP, GPT, SLC17A5
28disulfiram44 59 1112.5GPT, SLC17A5, TSPO
29hyaluronic acid44 2411.5SLC17A5, F2, GPT, HGF
30phosphorus4410.5SLC17A5, GPT, GC
31alpha-hydroxybutyrate4410.5SLC17A5, GPT
32silymarin4410.5GPT, F2, SLC17A5
33glycogen44 2411.5HGF, AFP, GPT, SLC17A5, OTC
34lactate4410.5HGF, AFP, GPT, F2, FST, SLC17A5
35iron44 2411.4CCL20, AFP, CD163, GPT, SLC17A5, ALAS1
36testosterone44 59 11 2413.4GC, HGF, AFP, FST, SLC17A5, TSPO
37fibrinogen4410.4GC, GTF3A, SLC17A5, F2, GPT, FGL2
38glutamine4410.4HGF, AFP, EIF2AK3, GPT, LECT2, SLC17A5
39valproate4410.4GPT, SLC17A5, OTC
40aspartate4410.4F2, GPT, EIF2AK3, F7, AFP, HGF
41steroid4410.4GC, AFP, FST, SEPSECS, GTF3A, TSPO
42atp44 2811.4HGF, GK, EIF2AK3, FST, SLC17A5, OTC
43pyridoxal 5-phosphate4410.4GPT, SLC17A5, ALAS1
44lipid4410.3GC, HGF, GK, AFP, CD163, F7
45alanine4410.3HGF, CCL20, AFP, EIF2AK3, GPT, F2
46creatinine4410.3TSPO, GC, HGF, GK, AFP, F7
47glycerol44 11 2412.2TSPO, OTC, EIF2AK3, GK
48Pyridoxal Phosphate1110.2GPT, SEPSECS, ALAS1
49nitric oxide44 11 2412.1F7, EIF2AK3, FST, SLC17A5, OTC, CCL20
50calcium44 49 11 2412.6GC, HGF, CCL20, AFP, CD163, F7

GO Terms for genes affiliated with Acute Liver Failure

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Sources:
16Gene Ontology
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Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0HGF, CCL20, CD163, F7, F2, FST
2extracellular spaceGO:0056159.7F2, GC, HGF, CCL20, AFP, F7

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:03019410.4F2, F7
2anion transportGO:00682010.3TSPO, SLC17A5
3peptidyl-glutamic acid carboxylationGO:01718710.1F2, F7

Molecular functions related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.3ALAS1, SEPSECS, GPT

Products for genes affiliated with Acute Liver Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Liver Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet