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MCID: ACT134

Acute Liver Failure malady
58 genes, 4 tissues, 822 related diseases, 21 phenotypes, 102 articles, clinical trials.

Summaries for Acute Liver Failure

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44Wikipedia, 22MalaCards
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Wikipedia: Acute liver failure is the appearance of severe complications rapidly after the first signs of liver...44 more...

MalaCards: Acute Liver Failure, also known as liver failure, acute, is related to hepatitis and hepatitis e. An important gene associated with Acute Liver Failure is FGL2 (fibrinogen-like 2), and among its related pathways are Graft-versus-host disease and RAR-Gamma-RXR-Alpha Degradation. The compounds ivig and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and endothelial, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions for Acute Liver Failure

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32Novoseek , 43UMLS
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acute liver failure 32
liver failure, acute 43

Related Diseases for Acute Liver Failure

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13GeneCards, 14GeneDecks
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Diseases related to acute liver failure by text searches and GeneDecks gene sharing:

(show top 50)    (show all 819)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4SEPSECS, FASLG, FAS, CCL20, GPT, F2
2hepatitis e29.7GPT, F2, ALB, SPARCL1, SLC17A5, GGT1
3wilson disease29.2IL1B, IL6, FAS, GPT, F2, ALB
4brain edema29.0IL1B, IL6, ALB, GLUL, HMOX1, OTC
5primary biliary cirrhosis29.0SEPSECS, MBL2, GPT, F2, ALB, CALR
6hemophagocytic lymphohistiocytosis27.8IL8, FAS, GPT, F2, GK, TNF
7leptospirosis27.6IL10, IL1B, IL6, F2, ALB, TNF
8hepatitis a26.4SEPSECS, IL10, IL1B, GPT, F5, F3
9septic shock25.2IL10, IL1B, IL6, IL8, MBL2, F5
10herpes simplex22.4GC, IL10, IL1B, IL6, IL8, FASLG
11myocardial infarction19.1GC, CD163, GSN, IL10, IL1B, IL6
12carcinoma14.7GC, SEPSECS, LECT2, FST, CD163, GTF3A
13alcoholic liver cirrhosis13.8GPT, HGF, AFP
14neonatal intrahepatic cholestasis caused by citrin deficiency13.7GPT, F2, SLC17A5
15non-a-e hepatitis13.7GPT, F2, SLC17A5
16citrin deficiency13.7GPT, F2, SLC17A5
17esophageal varix13.7F2, ALB, AFP
18reye syndrome13.7GPT, GLUL, OTC, ACADM
19vitamin k deficiency hemorrhagic disease13.6F7, F3, F2
20medium-chain acyl-coenzyme a dehydrogenase deficiency13.6OTC, ACADM
21acute fatty liver of pregnancy13.6F3, F2, ALB
22fournier gangrene13.6F3, F2, ALB
23hepatic tuberculosis13.6F2, ALB, GGT1
24hemarthrosis13.6F3, F2, F10
25dysprothrombinemia13.6F2, F10
26cirrhosis, noncryptogenic13.6KRT8, KRT18
27cirrhosis, cryptogenic13.6KRT8, KRT18
28acute intermittent porphyria13.6ALAS1, GLUL, HMOX1
29obstructive jaundice13.5GPT, SLC17A5, GGT1
30cortical blindness13.5F3, F2, POLG
31hepatocellular cancer13.5F2, GLUL, HGF, AFP
32achenbach syndrome13.5F3, F2, F10
33prostate disease13.5FST, ALB, KRT18, HGF
34hyperammonemia with hypoornithinemia13.5GLUL, OTC, TSPO, GGT1
35intracranial thrombosis13.5F5, F2, F10
36dubin-johnson syndrome13.5F7, ABCC1, ABCC4, ABCC5
37hemophilia b13.5F7, F3, F2, F10
38vitamin k-dependent clotting factors13.5F5, F2, F10
39stroke, ischemic13.5F5, F2
40al amyloidosis13.5LECT2, F10, CALR, CSF3
41vulvovaginal candidiasis13.5MBL2, F2, GGT1
42antithrombin iii deficiency13.5F5, F2, F10
43hypofibrinogenemia13.5F3, F2, ALB, CP
44choledocholithiasis13.5GPT, ALB, SLC17A5, GGT1
45factor v deficiency13.5F7, F5, F3, F2
46creatine phosphokinase13.5GPT, GLUL, SLC17A5, AFP, GGT1
47factor viii deficiency13.4F7, F5, F3, F2
48temporal lobe epilepsy13.4GLUL, GFAP, TSPO, SLC1A2
49factor xi deficiency13.4F7, F5, F3, F2
50infective endocarditis13.4GTF3A, MBL2, F2, EPO

Graphical network of the top 20 diseases related to acute liver failure:



Graphical network of diseases related to acute liver failure

Clinical Features for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for acute liver failure

Drug clinical trials:

Search ClinicalTrials for acute liver failure

Search NIH Clinical Center for acute liver failure

Search CenterWatch for acute liver failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for acute liver failure:
Hepatocyte transplantation for treatment of liver disorders
Embryonic/Adult Cultured Cells Related to acute liver failure:
Hepatocytes, PMIDs: 15239608, 9580649, 22167636, 12777539

Genetic Tests for Acute Liver Failure

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Anatomical Context for Acute Liver Failure

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21LifeMap Discovery™, 22MalaCards
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MalaCards organs/tissues related to acute liver failure:

22
Brain, Liver, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to acute liver failure:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Liver -> Liver Lobule -> Hepatocytes Potential therapeutic candidate, affected by disease

Phenotypes for genes affiliated with Acute Liver Failure

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25MGI
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MGI Mouse Phenotypes related to acute liver failure:

25 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.3FST, GSN
2endocrine/exocrine gland phenotypeMP:00053799.8FASLG, OTC, GSN, AFP, GGT1
3renal/urinary system phenotypeMP:00053679.8MAPK9, NPPA, ABCC4, OTC
4embryogenesis phenotypeMP:00053809.6POLG, KRT18, CALR, ALAS1, F2, MAPK9
5digestive/alimentary phenotypeMP:00053819.5GFAP, FST, MAPK8, MAPK9, F2, KRT8
6liver/biliary system phenotypeMP:00053709.2CYP2E1, LECT2, RGN, ACADM, OTC, GK
7hematopoietic system phenotypeMP:00053979.2HGF, LECT2, CSF3, POLG, THPO, EPO
8integument phenotypeMP:00107718.6POMC, POLG, GSN, ABCC4, CSF3, F3
9skeleton phenotypeMP:00053908.4POLG, GSN, IL6, FAS, PTGS2, FST
10nervous system phenotypeMP:00036318.1MAPK9, F5, FST, GSN, FASLG, MAPK8
11immune system phenotypeMP:00053877.8ABCC4, GSN, EIF2AK3, GFAP, POMC, GGT1
12growth/size phenotypeMP:00053787.5GK, KRT8, GGT1, HGF, MAPK8, POLG
13reproductive system phenotypeMP:00053897.3AFP, KRT8, SPARCL1, OTC, POLG, TNF
14muscle phenotypeMP:00053696.6MAPK9, CALR, HMOX1, TNF, PTGS2, ACADM
15vision/eye phenotypeMP:00053916.6GGT1, CP, SLC17A5, GFAP, SPARCL1, PTGS2
16behavior/neurological phenotypeMP:00053866.6GLUL, GK, HMOX1, OTC, CYP2E1, EIF2AK3
17tumorigenesisMP:00020066.2F3, TNF, PTGS2, CYP2E1, POMC, MAPK8
18mortality/agingMP:00107685.5GK, HMOX1, OTC, CYP2E1, KRT8, KRT18
19cellular phenotypeMP:00053845.1EIF2AK3, ABCC5, EPO, OTC, PTGS2, F3
20homeostasis/metabolism phenotypeMP:00053764.5LECT2, GK, HMOX1, PTGS2, OTC, CYP2E1
21cardiovascular system phenotypeMP:00053853.4ABCC4, F2, F3, F7, MAPK9, FAS

Publications for genes affiliated with Acute Liver Failure

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35PubMed
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Articles related to acute liver failure:

(show top 50)    (show all 102)
idTitleAuthorsYearAffiliating Genes
1Acetaminophen induced acute liver failure via oxidati ve stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. (20166895)Das J.... Sil P.C.2010CYP2E1
2Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome. (20196116)Kumar R.... Acharya S.K.2010F2
3Keratin variants predispose to acute liver failure an d adverse outcome: race and ethnic associations. (20538000)Strnad P.... M.B.2010KRT18, KRT8
4Regulatory polymorphisms in the IL-10 gene promoter and HBV-related acute liver failure in the Chinese population. (19413695)Yan Z.... Deng G.2009IL10
5Predictive criteria for the outcome of patients with acute liver failure treated with the albumin dialysis molecular adsorbent recir culating system. (19788457)Novelli G.... Berloco P.B.2009TNF, IL6, ALB
6Tumour necrosis factor-alpha and soluble Fas ligand a s biomarkers in non-acetaminophen-induced acute liver failure. (19505222)Singhal S.... Kar P.2009TNF, FASLG
7Liver function test results and outcomes in children with acute liver failure due to dengue infection. (19323033)Chongsrisawat V.... Poovorawan Y.2009F2
8Establishment of pig acute liver failure model and t he role of pig fibrinogen-like protein 2 (19785959)Guo J.W.... Ning Q.2009F10, FGL2
9Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. (18161828)Kortsalioudaki C.... Dhawan A.2008F2
10Emergency right lobe adult-to-adult live-donor liver transplantation for the treatment of acute liver failure following severe hepa titis (19094619)Lu S.C.... Li N.2008F7
11Cytokine profiles in acute liver failure treated with albumin dialysis. (18181803)Ilonen I.... Isoniemi H.2008ALB
12Quantitative multivoxel 1H MR spectroscopy of the brain in children with acute liver failure. (18493780)Sijens P.E.... Verkade H.J.2008GGT1, GPT
13The coagulopathy of acute liver failure and implications for intracranial pressure monitoring. (18379899)Munoz S.J.... Lee W.2008F2
14Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case. (18609519)Karvellas C.J.... Gibney R.T.2008ALB
15Acute liver failure in Lithuania. (18695350)Adukauskiene D.... Kupcinskas L.2008F2
16Acute liver failure in a child with Epstein-Barr virus infection and undiagnosed glycerol kinase deficiency, mimicking hemophagocytic lymphohistiocytosis. (18607276)Nordenstrom A.... von Dobeln U.2008GK
17Rapid diagnosis of Wilson disease in acute liver failure: no more waiting for the ceruloplasmin level? (18821595)O'Brien A.... Williams R.2008CP
18Efficacy and safety of coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration for multiple organ dysfunction syndrome patients with acute liver failure (17207366)He C.S.... Qin T.H.2007TNF, IL6, IL1B
19Diagnostic criteria for acute liver failure due to Wilson disease. (17461475)Eisenbach C.... Merle U.2007SLC17A5
20Soluble CD163 from activated macrophages predicts mortality in acute liver failure. (17629586)Moller H.J.... Lee W.M.2007CD163
21The significance of autoantibodies and immunoglobulin s in acute liver failure: a cohort study. (17602781)Bernal W.... Vergani D.2007SEPSECS
22Acute liver failure due to leptospirosis successfully treated with MARS (molecular adsorbent recirculating system) dialysis. (17203354)Covic A.... Gusbeth-Tatomir P.2007ALB
23Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis. (17657817)Leung P.S.... Gershwin M.E.2007SEPSECS
24Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. (17185352)Henderson N.C.... Simpson K.J.2007MAPK9, MAPK8
25Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine. (17900243)Higuchi N.... Enjoji M.2007GPT
26Ratio of circulating follistatin and activin A reflects the severity of acute liver injury and prognosis in patients with acute liver failure. (16509861)Lin S.D.... Suzuki K.2006FST
27Ornithine transcarbamoylase deficiency presenting with acute liver failure. (16802108)Mustafa A.... Clarke J.T.2006OTC
28Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. (16737880)Squires R.H.... Hynan L.S.2006F2
29Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure. (15826719)BAclanger M.... Butterworth R.F.2005TSPO
30Development of a rapid semi-quantitative immunochromatographic assay for serum hepatocyte growth factor and its usefulness in acute liver failure. (16293443)Uto H.... Tsubouchi H.2005HGF
31Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure. (15912107)Chen Y.... Tanaka N.2005HGF, ALB
32Schmidt syndrome presenting as acute liver failure. (15662598)Fiedler A.... Schroeder S.2005POMC
33Selection for acute liver failure: have we got it rig ht? (16237684)Blei A.T.2005AFP
34Increased heme oxygenase-1 and decreased delta-aminolevulinate synthase expression in the liver of patients with acute liver failure. (15547665)Fujii H.... Morita K.2004HMOX1, ALAS1
35Serum LECT2 level as a prognostic indicator in acute liver failure. (15561249)Sato Y.... Hatakeyama K.2004LECT2
36A case of acute liver failure caused by herpes simplex type 2. (15307595)Boysen T.... Clausen M.R.2004MBL2
37Acute liver failure. Current aspects of diagnosis and therapy (15098097)Bauer M.... Kortgen A.2004ALB
38Activin A and follistatin in acute liver failure. (12560755)Hughes R.D.... Evans L.W.2003FST
39Brain edema in acute liver failure. (15025258)Butterworth R.F.2003SLC1A2
40Caspase 8 small interfering RNA prevents acute liver failure in mice. (12810955)Zender L.... Kubicka S.2003FAS
41Thrombopoietin in acute liver failure. (12601353)Schiodt F.V.... Lee W.M.2003THPO
42Hepatocyte transplantation in acute liver failure. (10648575)Bilir B.M.... Durham J.2000F2
43Granulocyte colony-stimulating factor improves function of neutrophils from patients with acute liver failure. (11057460)Rolando N.... Williams R.2000CSF3
44Carbohydrate 19-9 antigen as a marker of non-malignant hepatocytic ductular transformation in patients with acute liver failure. A comparison with alpha-fetoprotein and carcinoembryonic antigen. (10365905)Halme L.... HAPckerstedt K.1999AFP
45Acute liver failure. (11132456)Kelly D.A.1999F2
46Acute liver failure after therapeutic hyperthermia (10599246)Hammerschmidt S.... Scheppach W.1999F3
47Halothane-induced acute liver failure: continuing occurrence and use of liver transplantation. (9744690)Lo S.K.... Williams R.1998F2
48Liver transplantation for acute liver failure: outcome analysis. (9097288)Shakil A.O.... Rakela J.1997F2
49Acute liver failure due to diffuse intrasinusoidal metastases of urothelial carcinoma. (8903067)Alcalde M.... de Santamaria J.S.1996SLC17A5
50In vivo evidence of enhanced guanylyl cyclase activation during the hyperdynamic circulation of acute liver failure. (7903953)Schneider F.... TempAc J.D.1994NPPA

Expression for genes affiliated with Acute Liver Failure

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Pathways for genes affiliated with Acute Liver Failure

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20KEGG, 36QIAGEN, 10EMD Millipore, 37R&D Systems, 41Thomson Reuters
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Pathways related to acute liver failure according to GeneDecks:

(show top 50)    (show all 73)
idPathwayScoreTop Affiliating Genes
1Graft-versus-host disease2010.6FASLG
2RAR-Gamma-RXR-Alpha Degradation3610.5MAPK9, CCL20, CSF3
3Development HGF signaling pathway1010.3MAPK8, HGF, MAPK9
4Extrinsic Prothrombin Activation Pathway3610.0F7, F5, F3, F2, F10
5Blood Coagulation Signaling Pathways3710.0F2, F3, F10, F7, F5
6Immune response_Bacterial infections in normal airways419.9IL1B
7Development_HGF signaling pathway419.9MAPK9, MAPK8, HGF, FAS
8Complement and coagulation cascades209.8F10, F2, F3, F5, F7, MBL2
9Regulation of eIF4 and p70S6K369.7IL6, MAPK8, MAPK9
10Pathways in cancer209.7FAS, MAPK8, MAPK9, HGF
11Signal transduction_JNK pathway419.5MAPK9, FASLG, FAS, MAPK8, TNF
12Signal transduction JNK pathway109.4TNF, MAPK9, FAS, FASLG, MAPK8
13IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types379.3TNF, IL10, FAS, FASLG
14Molecular Mechanisms of Cancer369.1HGF, CCL20, MAPK8, IL6
15Transcription_Role of VDR in regulation of genes involved in osteoporosis418.7IL1B, IL6, FASLG, TNF, CALR
16Immune response_MIF-mediated glucocorticoid regulation418.6PTGS2, TNF, IL8, IL6
17Transcription Role of VDR in regulation of genes involved in osteoporosis108.6IL1B, IL6, FASLG, TNF, CALR
18Immune response MIF-mediated glucocorticoid regulation108.6PTGS2, TNF, IL8, IL6
19Selected targets of GCR-alpha108.5FASLG, IL8, IL6, IL1B, GLUL
20Endothelin-1 Signaling Pathway368.5CSF3, MAPK9, IL6, CCL20, IL1B, IL10
21Hematopoietic cell lineage208.3EPO, CSF3, THPO, TNF, IL6, IL1B
22NOD-like receptor signaling pathway208.2IL6, MAPK8, MAPK9, TNF, IL8, IL1B
23IL-10 Pathway368.2HMOX1, IL10, IL1B, IL6, TNF
24African trypanosomiasis208.0TNF, IL6, FASLG, FAS, IL1B, IL10
25Toll-like receptor signaling pathway208.0MAPK9, IL1B, MAPK8, TNF, IL6, IL8
26Cytokine Network368.0IL6, IL10, TNF, IL8, IL1B
27Rho Family GTPases367.8THPO, IL10, IL1B, IL8, CSF3, MAPK8
28Immune response_MIF in innate immunity response417.7IL6, IL1B, PTGS2, TNF, MAPK9, MAPK8
29Immune response MIF in innate immunity response107.7TNF, MAPK9, MAPK8, IL8, IL6, IL1B
30Malaria207.7IL10, IL6, HGF, CSF3, TNF, IL8
31TGF-Beta Pathway367.7IL10, IL1B, CCL20, THPO, HGF, MAPK8
32Influenza A207.7IL1B, IL6, IL8, FASLG, MAPK8, EIF2AK3
33Glucocorticoid Receptor Signaling367.7IL6, IL10, IL1B, IL8, MAPK8, MAPK9
34Pertussis207.6IL10, IL1B, IL6, TNF, IL8, MAPK9
35PEDF Induced Signaling367.6HGF, CSF3, IL6, IL1B, IL10, CCL20
36IL-6 Pathway367.6IL10, IL8, CCL20, TNF, HGF, IL6
37JAK-STAT Pathway367.5EPO, HGF, IL10, THPO, F2, CCL20
38MAPK Family Pathway367.3HGF, IL1B, CCL20, IL10, IL6, MAPK8
39Tec Kinases Signaling367.3HGF, IL8, THPO, MAPK9, TNF, CCL20
40STAT3 Pathway367.2HGF, CSF3, CCL20, MAPK9, MAPK8, IL8
41Immune response_IL-1 signaling pathway417.1TNF, IL1B, CP, IL6, IL8, MAPK8
42Immune response IL-1 signaling pathway107.1F3, HMOX1, TNF, CP, PTGS2, IL6
43MIF Mediated Glucocorticoid Regulation367.1IL6, IL1B, IL10, CCL20, TNF, PTGS2
44all-trans-Retinoic Acid Signaling in Brain367.1IL10, HGF, TNF, CCL20, IL8, CSF3
45PAK Pathway367.1IL1B, IL10, CCL20, IL6, IL8, MAPK8
46Antioxidant Action of Vitamin-C367.0TNF, HGF, IL6, CSF3, MAPK9, MAPK8
47Chagas disease (American trypanosomiasis)207.0IL6, MAPK8, CALR, TNF, IL1B, IL10
48p38 Signaling367.0THPO, TNF, CCL20, IL8, IL6, HGF
49Cytokine-cytokine receptor interaction206.8IL1B, CSF3, CCL20, TNF, EPO, FAS
50MIF Regulation of Innate Immune Cells366.7TNF, MAPK9, CCL20, IL8, PTGS2, HGF

Compounds for genes affiliated with Acute Liver Failure

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32Novoseek , 9DrugBank, 34PharmGKB, 18HMDB, 42Tocris Bioscience
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Compounds related to acute liver failure according to GeneDecks:

(show top 50)    (show all 399)
idCompoundScoreTop Affiliating Genes
1ivig32 10.4FASLG, SEPSECS, GTF3A
2n acetylcysteine32 10.2GPT, F2, CALR, KRT18, SLC17A5, HGF
3aprotinin32 9 9 11.9F2, F10, F5
4glucose32 9.9KRT8, KRT18, EIF2AK3, THPO, OTC, CALR
5hepaplastin32 9.8ALB, SLC17A5, HGF
6acetaminophen32 34 9 18 9 13.5GC, GPT, F5, F2, F10, KRT18
7endotoxin32 9.5CCL20, SLC17A5, CSF3, F3, F5, FASLG
8polyethylene glycol32 9.3F10, GFAP, NPPA, HMOX1, AFP
9h2o232 9.2SLC1A2, SLC17A5, POMC, THPO, MAPK8, TSPO
10urea32 9 18 9 12.2GGT1, GC, GPT, F5, ALB, CALR
11heparin32 9 18 9 12.2FST, GSN, F3, F2, ALB, F10
12sb 20358032 42 10.2IL6, F10, HMOX1, TNF, CYP2E1, THPO
13ascorbic acid32 18 10.1CYP2E1, KRT18, POMC, SLC17A5, RGN, EPO
14cysteine32 9.1FST, GTF3A, GSN, KRT8, CP, SLC1A2
15glutamate32 8.9MAPK9, GPT, GSN, LECT2, GC, CP
16phenobarbital32 9 9 10.8TSPO, ABCC1, CYP2E1, CP, ALAS1, GPT
17aspartate32 8.6GC, FASLG, MBL2, F7, F5, F2
18estrogen32 8.5GC, FST, F2, F10, GLUL, HMOX1
19epinephrine32 9 18 9 11.3AFP, NPPA, SLC17A5, CP, THPO, FASLG
20testosterone32 9 18 9 11.3AFP, EPO, HGF, GC, FST, GSN
21fibrinogen32 8.2F7, GPT, MBL2, IL6, FGL2, GSN
22zidovudine32 9 9 10.1F3, ABCC4, IL10, EPO, SLC17A5, POLG
23glutamine32 7.9LECT2, FAS, GPT, F5, F10, CALR
24cyclosporin a32 42 8.8POMC, NPPA, SLC17A5, HGF, TSPO, ABCC4
25butyrate32 7.7GSN, IL8, FASLG, FAS, MAPK8, ALAS1
26oxygen32 18 8.6KRT18, EIF2AK3, ACADM, GFAP, THPO, POLG
27prednisolone32 9 9 9.6POMC, CSF3, GPT, SLC17A5, MBL2, HGF
28atorvastatin32 34 9 18 9 11.6F5, HMOX1, GPT, FASLG, IL6, TNF
29creatinine32 7.3GC, FST, FAS, MBL2, F7, F5
30simvastatin32 34 42 9 18 9 12.3F5, F3, F2, F10, HMOX1, TNF
31iron32 18 8.2HMOX1, PTGS2, KRT8, KRT18, GFAP, THPO
32cisplatin32 34 9 9 10.0FASLG, FAS, MAPK8, MAPK9, F10, HMOX1
33pdtc32 6.9IL6, IL8, MAPK8, F3, HMOX1, TNF
34lipid32 6.9HGF, AFP, GGT1, CP, MBL2, MAPK9
35superoxide32 18 7.8GC, GSN, IL1B, IL8, MBL2, MAPK8
36thalidomide32 42 9 9 9.8CYP2E1, FASLG, AFP, EPO, HGF, IL6
37ly29400232 6.8IL10, IL1B, IL6, IL8, FASLG, MAPK8
38alanine32 6.6GSN, GTF3A, IL6, FASLG, CCL20, GPT
39nitric oxide32 9 18 9 9.5FST, IL10, IL1B, IL6, IL8, FASLG
40indomethacin32 9 9 8.3PTGS2, ABCC1, ABCC4, TSPO, THPO, POMC
41thymidine32 18 7.3FST, KRT18, TNF, THPO, GFAP, FASLG
42methotrexate32 34 42 9 9 10.2IL10, IL1B, IL6, FASLG, GPT, F2
43genistein32 9 18 9 9.1HGF, CYP2E1, KRT8, ABCC1, GFAP, THPO
44actinomycin d32 5.9ABCC1, THPO, HGF, AFP, KRT18, KRT8
45vegf32 5.9CCL20, EPO, AFP, HGF, CP, F5
46serine32 5.7GC, SEPSECS, FST, GTF3A, GSN, FGL2
47retinoic acid32 42 18 7.7IL1B, IL6, FASLG, FAS, MAPK8, F5
48lactate32 5.3SLC17A5, SLC1A2, CP, HGF, EPO, AFP
49cycloheximide32 4.8FST, POMC, HGF, CSF3, GFAP, IL10
50dexamethasone32 42 34 9 9 8.0KRT18, GFAP, THPO, CSF3, POMC, CP

GO Terms for genes affiliated with Acute Liver Failure

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12Gene Ontology
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Cellular components related to acute liver failure according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484719.1ABCC5, KRT18, CALR, FAS, FASLG, GSN
2extracellular regionGO:0055765.2FASLG, EPO, FAS, IL8, IL6, IL1B
3extracellular spaceGO:0056154.0AFP, F3, F5, F7, CCL20, MBL2

Biological processes related to acute liver failure according to GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:01718710.4F7, F2, F10
2blood coagulation, extrinsic pathwayGO:00759810.4F10, F3, F7
3positive regulation of necrotic cell deathGO:01094010.1TSPO, FAS, TNF
4positive regulation of platelet-derived growth factor receptor signaling pathwayGO:01064110.1F7, F3
5acute-phase responseGO:0069539.9CD163, F2, MBL2, IL6
6induction of apoptosis via death domain receptorsGO:0086259.7FASLG, TNF, FAS
7inflammatory cell apoptotic processGO:0069259.7FASLG, FAS
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.7TNF, F3, FAS, EIF2AK3, FASLG
9positive regulation of protein kinase B signaling cascadeGO:0518979.7F7, F10, TNF, F3
10response to estrogen stimulusGO:0436279.6F7, FAS, EPO, HMOX1
11response to insulin stimulusGO:0328689.5IL10, OTC, ABCC5, NPPA
12negative regulation of growth of symbiont in hostGO:0441309.5TNF, MBL2, IL10
13response to oxidative stressGO:0069799.5MBL2, HMOX1, ABCC1, PTGS2, PEBP1
14blood coagulationGO:0075969.4F5, F3, F7, F2, ALB, F10
15platelet activationGO:0301689.3HGF, THPO, ABCC4, ALB, F2, F5
16positive regulation of chemokine biosynthetic processGO:0450809.3HMOX1, IL1B, TNF
17transmembrane transportGO:0550859.2HMOX1, SLC1A2, ABCC1, ABCC4, ABCC5, SLC17A5
18response to lipopolysaccharideGO:0324969.1EPO, PTGS2, FASLG, FAS, THPO, ABCC5
19regulation of blood pressureGO:0082179.1NPPA, PTGS2, HMOX1, POMC
20positive regulation of fever generationGO:0316229.1TNF, PTGS2, IL1B
21positive regulation of smooth muscle cell proliferationGO:0486619.1IL6, HMOX1, PTGS2, TNF
22response to estradiol stimulusGO:0323559.1GC, IL1B, CALR, PTGS2, F3
23agingGO:0075689.0PEBP1, TSPO, F3, FAS, IL1B, GSN
24positive regulation of cell proliferationGO:0082848.8EPO, FASLG, THPO, CALR, F2, CSF3
25small molecule metabolic processGO:0442818.5GK, GC, GPT, ACADM, POMC, GGT1
26positive regulation of apoptotic processGO:0430658.4TSPO, PTGS2, TNF, IL1B, FASLG, FAS
27response to drugGO:0424938.3FAS, TNF, IL10, ABCC1, OTC, PTGS2
28anti-apoptosisGO:0069167.7IL10, EPO, HGF, TNF, HMOX1, F3
29response to glucocorticoid stimulusGO:0513847.7IL1B, IL6, FAS, TNF, PTGS2, IL10
30inflammatory responseGO:0069547.3IL6, IL10, TNF, PTGS2, CCL20, IL8

Molecular functions related to acute liver failure according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.0SEPSECS, GPT, ALAS1, ALB
2receptor bindingGO:0051028.9FGL2, FASLG, MBL2, F7, F2, POMC
3growth factor activityGO:0080837.9IL1B, IL6, F2, THPO, CSF3, HGF
4cytokine activityGO:0051257.6THPO, TNF, FASLG, IL6, IL1B, IL10

Sources for Acute Liver Failure

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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