Acute Liver Failure disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MCID: ACT134 MIFTS: 57	Acute Liver Failure malady Liver diseases category
63 genes, 17 tissues, 179 related diseases, clinical trials.

Summaries for Acute Liver Failure

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis and hepatitis a. An important gene associated with Acute Liver Failure is F2 (coagulation factor II (thrombin)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds d-galactosamine and 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Acute Liver Failure

Sources:
³⁰LifeMap Discovery™, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁶⁰UMLS, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases

ICD10: ²⁶

Diseases of the digestive system

Diseases of liver

Hepatic failure, not elsewhere classified

Acute and subacute hepatic failure

Characteristics (Orphanet epidemiological data):

⁴⁸

acute liver failure:
Prevalence: 1-5/10000

Aliases & Descriptions:

acute liver failure ³⁰ ⁴⁴ ⁴⁸

acute hepatic failure ⁴⁸

liver failure, acute ⁶⁰

liver failure acute ⁴⁴

External Ids:

MESH via Orphanet³⁵ D017114

ICD10 via Orphanet²⁶ K72.0

SNOMED-CT via Orphanet⁵⁷ 197270009

UMLS via Orphanet⁶¹ C0162557

Related Diseases for Acute Liver Failure

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Liver Disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 179)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	31.3	GPT, SLC17A5
2	hepatitis a	31.0	F2
3	wilson disease	30.7	OTC, SLC17A5, GPT
4	hepatitis b	30.7	SLC17A5, F2, GPT, FGL2, AFP
5	liver cirrhosis	30.6	HGF, AFP, GPT, F2, SLC17A5, TSPO
6	herpes simplex	30.6	GC
7	hepatitis e	30.6	GPT
8	hepatic encephalopathy	30.5	GC, GPT, F2, SLC17A5, TSPO
9	hypertension	30.5	F2
10	autoimmune hepatitis	30.5	SEPSECS
11	leukemia	30.4	CCL20, EIF2AK3, FST, OTC
12	pancreatitis	30.2	SLC17A5
13	acute pancreatitis	30.2	SLC17A5, GPT
14	porphyria	30.2	ALAS1
15	viral hepatitis	30.2	AFP, FGL2, GPT, F2, SLC17A5, SEPSECS
16	endometriosis	30.0	FST, HGF, GC
17	ischemia	30.0	HGF, EIF2AK3, FST, SLC17A5
18	cholangiocarcinoma	30.0	HGF, AFP
19	arthritis	30.0	CCL20, CD163
20	tuberculosis	30.0	GC
21	acute myocardial infarction	30.0	F7
22	hepatic coma	30.0	F2, TSPO
23	myocardial infarction	30.0	F7, CD163
24	cholestasis	30.0	GPT, F2, SLC17A5
25	portal hypertension	30.0	GPT, F2, SLC17A5
26	alcoholic liver cirrhosis	30.0	SLC17A5, F2, GPT
27	factor x deficiency	30.0	F7, F2
28	alcoholic hepatitis	30.0	F2, HGF
29	primary biliary cirrhosis	30.0	GPT, F2, SLC17A5, SEPSECS
30	hepatitis c	30.0	AFP, GPT, F2, SLC17A5
31	brain disease	30.0	GC, GPT, F2, SLC17A5, OTC, TSPO
32	myopathy	30.0	SLC17A5, GPT, GK
33	hepatocellular carcinoma	30.0	HGF, CCL20, AFP, F7, EIF2AK3, GPT
34	brain edema	10.7
35	liver disease	10.7
36	cerebritis	10.5
37	acute kidney failure	10.4
38	liver failure acute infantile	10.4
39	liver lymphoma	10.3
40	acute leukemia	10.3
41	hemophagocytic lymphohistiocytosis	10.3
42	acute t cell leukemia	10.3
43	aplastic anemia	10.3
44	respiratory failure	10.3
45	t-cell leukemia	10.3
46	hypophosphatemia	10.2
47	adult t-cell leukemia	10.2
48	leptospirosis	10.2
49	polyarteritis nodosa	10.2
50	acute porphyria	10.2

Graphical network of the top 20 diseases related to Acute Liver Failure:

Clinical Features for Acute Liver Failure

Drugs & Therapeutics for Acute Liver Failure

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ³⁰LifeMap Discovery™, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Liver Failure

Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Search CenterWatch for Acute Liver Failure

Cell-based therapeutics:

The database of embryonic development, stem cell research and regenerative medicine

Read about Acute Liver Failure cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Acute Liver Failure:

	Hepatocyte transplantation for treatment of liver disorders
	Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases

Embryonic/Adult Cultured Cells Related to Acute Liver Failure:

	Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
	Hepatocytes

Genetic Tests for Acute Liver Failure

Anatomical Context for Acute Liver Failure

Sources:
³⁰LifeMap Discovery™, ³²MalaCards
See all sources

MalaCards organs/tissues related to Acute Liver Failure:

³²

Liver, Brain, T cells, Kidney, Testes, Bone, Breast, Bone marrow, Endothelial, Heart, Monocytes, Lung, Pancreas, B cells, Nk cells, Skeletal muscle

The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:

id	TissueAnatomical CompartmentCell	Relevance
1	LiverLiver LobuleHepatocytes	Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Acute Liver Failure:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	9.7	GK, AFP, F7, FGL2, EIF2AK3, LECT2
2	mortality/aging	MP:0010768	9.4	ALAS1, HGF, GK, AFP, F7, FGL2

Publications for Acute Liver Failure

Sources:
⁵⁰PubMed
See all sources

Articles related to Acute Liver Failure:

(show top 50) (show all 716)

id	Title	Authors	Year
1	Elevated expression of tumour necrosis factor-I+-induced protein 8 (TNFAIP8)-like 2 mRNA in peripheral blood mononuclear cells is associated with disease progression of acute-on-chronic hepatitis B liver failure. (24329858)	Wang L.Y.... Wang K.	2014
2	Living donor liver transplant in pediatric acute liver failure: an important option, but when do we use it? (24385021)	Squires R.H.	2014
3	Aquaporin-4 deletion in mice reduces encephalopathy and brain edema in experimental acute liver failure. (24321433)	Rama Rao K.V.... Norenberg M.D.	2014
4	Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure. (24104197)	Court M.H.... Lee W.M.	2014
5	Acute Liver Failure Associated With Traditional Chinese Medicine: Report of 30 Cases From Seven Tertiary Hospitals in China. (24335449)	Zhao P.... Liu W.	2014
6	TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. (23532086)	Chen F.... Nguyen J.H.	2013
7	Serum Testosterone Levels and Androgen Receptor CAG Polymorphism Correlate with Hepatitis B Virus (HBV)-Related Acute Liver Failure in Male HBV Carriers. (24391916)	Xu B.Y.... Deng G.H.	2013
8	Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. (23489904)	YtrebA... Rose C.F.	2013
9	Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure. (23215950)	Zhang G.L.... Gao Z.L.	2013
10	Acute liver failure. (24160932)	Whitehouse T.... Wendon J.	2013
11	Use of acetylcysteine for non-acetaminophen-induced acute liver failure. (23293188)	Sales I.... Kane-Gill S.L.	2013
12	Molecular Adsorbent Recirculating System (MARS(Ar)) removal of piperacillin/tazobactam in a patient with acetaminophen-induced acute liver failure. (23279615)	Ruggero M.A.... Topal J.E.	2013
13	Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival. (23782487)	Stravitz R.T.... Lee W.M.	2013
14	Predicting the prognosis in acute liver failure: results from a retrospective pilot study using the LiMAx test. (23813133)	Lock J.F.... Stockmann M.	2013
15	Etiology and prognostic factors of acute liver failure in children. (23255683)	Kaur S.... Kumar A.	2013
16	Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model. (23498809)	Hu X.... Zhou P.	2013
17	Causality of Drugs Involved in Acute Liver Failure Leading to Transplantation: Results from the Study of Acute Liver Transplant (SALT). (23743692)	Gulmez S.E.... Larrey D.	2013
18	Posterior reversible encephalopathy syndrome in a survivor of valproate-induced acute liver failure: a case report. (23724918)	Mettananda S.... Ginige N.	2013
19	Should N-acetylcysteine be used in treatment of non-acetaminophen pediatric acute liver failure? (24222292)	Kumar V.	2013
20	GABAergic neurosteroids: the "endogenous benzodiazepines" of acute liver failure. (22041164)	Ahboucha S.... Baker G.	2012
21	Acute liver failure in children: 20-year experience. (22706740)	BariA9 Z.... YA1ce A.	2012
22	Algorithm to determine the outcome of patients with acute liver failure: a data-mining analysis using decision trees. (22402772)	Nakayama N.... Mochida S.	2012
23	Hodgkin disease relapse discovered at the time of liver transplant for acute liver failure. (21054714)	Hope B.C.... Chin S.E.	2012
24	Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. (22532075)	Marques P.E.... Menezes G.B.	2012
25	Correlation of the intracranial pressure to the central venous pressure in the late phase of acute liver failure in a porcine model. (22327729)	Scheuermann K.... Schenk M.	2012
26	Recent developments in acute liver failure. (22482521)	Lee W.M.	2012
27	Increased mortality from acute liver failure in Mexico. (22345344)	ChA!vez-Tapia N.C.... Uribe M.	2012
28	Early myocardial injury is an integral component of experimental acute liver failure - a study in two porcine models. (22291759)	Papoutsidakis N.... Kostopanagiotou G.	2011
29	Invasive versus noninvasive intracranial pressure monitoring in children with acute liver failure. (22067827)	Devictor D.... Tissieres P.	2011
30	Acute liver failure in children. (21531191)	Devictor D.... Debray D.	2011
31	Expression of COX-2 and PPARg in the livers of patients with acute on chronic HBV-related liver failure and their relationship with clinic parameters]. (22152242)	Niu Y.H.... Zhao Y.R.	2011
32	Transplantation of encapsulated hepatocytes during acute liver failure improves survival without stimulating native liver regeneration. (21396154)	Sgroi A.... Buhler L.H.	2011
33	Acute liver failure after recommended doses of acetaminophen in patients with myopathies. (21242792)	Ceelie I.... de Wildt S.N.	2011
34	HMGB1 cytoplasmic translocation in patients with acute liver failure. (21406085)	Zhou R.R.... Fan X.G.	2011
35	A Src family kinase inhibitor improves survival in experimental acute liver failure associated with elevated cerebral and circulating vascular endothelial growth factor levels. (21745297)	Aspinall R.J.... Cheresh D.A.	2011
36	Transplantation of immortalized human fetal hepatocytes prevents acute liver failure in 90% hepatectomized mice. (20620547)	Chen Y.... Wang X.	2010
37	Acute liver failure secondary to gemcitabine. (22736319)	Stellman A.... Mann S.	2010
38	Echocardiographic diagnosis of systemic AA amyloidosis presenting with acute liver failure. (20821940)	Morelli S.... Galasso L.	2010
39	Acute liver failure associated with rubella virus in a child. (20228694)	Figueiredo C.A.... Durigon E.L.	2010
40	Acute-on-chronic liver failure due to thiamazole in a patient with hyperthyroidism and trilogy of Fallot: case report. (20707932)	Shen C.... Yu J.	2010
41	Intensive care management of children with acute liver failure. (20799075)	Bhatia V.... Lodha R.	2010
42	Cytokine and autoantibody patterns in acute liver failure. (20039781)	Li J.... Uetrecht J.	2010
43	Acute liver failure: managing coagulopathy and the bleeding diathesis. (19460532)	De Gasperi A.... Bettinelli L.	2009
44	Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case. (18609519)	Karvellas C.J.... Gibney R.T.	2008
45	Effects of granulocyte colony-stimulating factor on hepatocyte apoptosis in acute liver failure: experiment with rats]. (18756972)	Kang W.... Lou S.	2008
46	Prevention and management of brain edema in patients with acute liver failure. (18825686)	Larsen F.S.... Wendon J.	2008
47	Evolution of hepatorenal syndrome after orthotopic liver transplantation: comparative analysis with patients who developed acute renal failure in the early postoperative period of liver transplantation. (17889176)	LA^pez Lago A.M.... PAcrez E.V.	2007
48	Alpha-fetoprotein and prognosis in acute liver failure. (17133565)	SchiA... Lee W.M.	2006
49	Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. (16737880)	Squires R.H.... Hynan L.S.	2006
50	Increased heme oxygenase-1 and decreased delta-aminolevulinate synthase expression in the liver of patients with acute liver failure. (15547665)	Fujii H.... Morita K.	2004

Genes related to Acute Liver Failure

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Acute Liver Failure:

(show top 50) (show all 63)

id	Symbol	Description	Score	Implication
1	F2	coagulation factor II (thrombin)	20.15	GeneCards inferred : Publications, Disorders (show sections)
2	SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	19.83	GeneCards inferred : Publications, Disorders (show sections)
3	GK	glycerol kinase	19.52	GeneCards inferred : Publications, Disorders (show sections)
4	GC	group-specific component (vitamin D binding protein)	19.20	GeneCards inferred : Publications, Disorders (show sections)
5	TSPO	translocator protein (18kDa)	18.88	GeneCards inferred : Publications, Disorders (show sections)
6	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	18.56	GeneCards inferred : Publications, Disorders (show sections)
7	SLC17A5	solute carrier family 17 (acidic sugar transporter), member 5	18.25	GeneCards inferred : Publications, Disorders (show sections)
8	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	17.93	GeneCards inferred : Publications, Disorders (show sections)
9	AFP	alpha-fetoprotein	17.61	GeneCards inferred : Publications, Disorders (show sections)
10	F7	coagulation factor VII (serum prothrombin conversion accelerator)	17.29	GeneCards inferred : Publications, Disorders (show sections)
11	EIF2AK3	eukaryotic translation initiation factor 2-alpha kinase 3	16.98	GeneCards inferred : Publications, Disorders (show sections)
12	OTC	ornithine carbamoyltransferase	16.66	GeneCards inferred : Publications, Disorders (show sections)
13	RGN	regucalcin	16.34	GeneCards inferred : Publications, Disorders (show sections)
14	FGL2	fibrinogen-like 2	16.03	GeneCards inferred : Publications, Disorders (show sections)
15	LECT2	leukocyte cell-derived chemotaxin 2	15.71	GeneCards inferred : Publications, Disorders (show sections)
16	FST	follistatin	15.39	GeneCards inferred : Publications, Disorders (show sections)
17	ALAS1	aminolevulinate, delta-, synthase 1	15.07	GeneCards inferred : Publications, Disorders (show sections)
18	CD163	CD163 molecule	14.76	GeneCards inferred : Publications, Disorders (show sections)
19	CCL20	chemokine (C-C motif) ligand 20	14.44	GeneCards inferred : Publications, Disorders (show sections)
20	GTF3A	general transcription factor IIIA	14.12	GeneCards inferred : Publications, Disorders (show sections)
21	THPO	thrombopoietin	13.80	GeneCards inferred : Publications, Disorders (show sections)
22	POLG	polymerase (DNA directed), gamma	13.49	GeneCards inferred : Publications, Disorders (show sections)
23	PEBP1	phosphatidylethanolamine binding protein 1	13.17	GeneCards inferred : Publications, Disorders (show sections)
24	ALB	albumin	12.85	GeneCards inferred : Publications, Disorders (show sections)
25	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	12.53	GeneCards inferred : Publications, Disorders (show sections)
26	MAPK9	mitogen-activated protein kinase 9	12.22	GeneCards inferred : Publications, Disorders (show sections)
27	CALR	calreticulin	11.90	GeneCards inferred : Publications, Disorders (show sections)
28	GLUL	glutamate-ammonia ligase	11.58	GeneCards inferred : Publications, Disorders (show sections)
29	ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	11.26	GeneCards inferred : Publications, Disorders (show sections)
30	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	10.95	GeneCards inferred : Publications, Disorders (show sections)
31	MBL2	mannose-binding lectin (protein C) 2, soluble	10.63	GeneCards inferred : Publications, Disorders (show sections)
32	ABCC5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	10.31	GeneCards inferred : Publications, Disorders (show sections)
33	SPARCL1	SPARC-like 1 (hevin)	9.99	GeneCards inferred : Publications, Disorders (show sections)
34	HMOX1	heme oxygenase (decycling) 1	9.68	GeneCards inferred : Publications, Disorders (show sections)
35	GSN	gelsolin	9.36	GeneCards inferred : Publications, Disorders (show sections)
36	GGT1	gamma-glutamyltransferase 1	9.04	GeneCards inferred : Publications, Disorders (show sections)
37	F10	coagulation factor X	8.72	GeneCards inferred : Publications, Disorders (show sections)
38	KRT18	keratin 18	8.41	GeneCards inferred : Publications, Disorders (show sections)
39	CP	ceruloplasmin (ferroxidase)	8.09	GeneCards inferred : Publications, Disorders (show sections)
40	KRT8	keratin 8	7.77	GeneCards inferred : Publications, Disorders (show sections)
41	FASLG	Fas ligand (TNF superfamily, member 6)	7.45	GeneCards inferred : Publications, Disorders (show sections)
42	POMC	proopiomelanocortin	7.14	GeneCards inferred : Publications, Disorders (show sections)
43	ABCC4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	6.82	GeneCards inferred : Publications, Disorders (show sections)
44	GFAP	glial fibrillary acidic protein	6.50	GeneCards inferred : Publications, Disorders (show sections)
45	NPPA	natriuretic peptide A	6.18	GeneCards inferred : Publications, Disorders (show sections)
46	F3	coagulation factor III (thromboplastin, tissue factor)	5.87	GeneCards inferred : Publications, Disorders (show sections)
47	F5	coagulation factor V (proaccelerin, labile factor)	5.55	GeneCards inferred : Publications, Disorders (show sections)
48	CSF3	colony stimulating factor 3 (granulocyte)	5.23	GeneCards inferred : Publications, Disorders (show sections)
49	MAPK8	mitogen-activated protein kinase 8	4.91	GeneCards inferred : Publications, Disorders (show sections)
50	FAS	Fas cell surface death receptor	4.60	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Acute Liver Failure disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	49	49	49
2	LSBio	-	-	50

Genetic Variations for Acute Liver Failure

Expression for genes affiliated with Acute Liver Failure

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

Sources:
⁵³Reactome, ⁴⁹PharmGKB, ⁵¹QIAGEN, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Acute Liver Failure according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins⁵³ Hide members Removal of aminoterminal propeptides from gamma-carboxylated proteins⁵³ Warfarin Pathway, Pharmacodynamics⁴⁹ Gamma-carboxylation of protein precursors⁵³ Extrinsic Pathway⁵³ Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus⁵³	10.4	F2, F7
2	Common Pathway⁵³ Hide members Extrinsic Prothrombin Activation Pathway⁵¹	10.4	F2, F7
3	FOXA2 and FOXA3 transcription factor networks³⁷	10.3	ALAS1, F2, AFP

Compounds for genes affiliated with Acute Liver Failure

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ²⁸IUPHAR, ²⁴HMDB, ⁵⁹Tocris Bioscience, ⁴⁹PharmGKB, ²BitterDB
See all sources

Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show top 50) (show all 75)

id	Compound	Score	Top Affiliating Genes
1	d-galactosamine⁴⁴	10.7	HGF, GPT, SLC17A5
2	5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)¹¹	10.7	F2, F7
3	aminopyrine⁴⁴	10.7	GPT, F2, SLC17A5
4	hepaplastin⁴⁴	10.7	HGF, GPT, F2, SLC17A5
5	lamivudine⁴⁴ ¹¹	11.7	SLC17A5, F2
6	lidocaine⁴⁴ ²⁸ ¹¹	12.7	TSPO, SLC17A5, F2, HGF
7	ursodeoxycholic acid⁴⁴ ¹¹ ²⁴	12.7	HGF, GPT, F2, SLC17A5
8	levonorgestrel⁴⁴ ⁵⁹ ²⁸ ¹¹	13.7	F7, F2, SLC17A5
9	isoflurane⁴⁴ ¹¹	11.6	TSPO, SLC17A5, GPT
10	vitamin a⁴⁴ ¹¹ ²⁴	12.6	GC, HGF, FST, GTF3A
11	glutamate⁴⁴	10.6	GPT, LECT2, OTC, TSPO
12	pge1⁴⁴	10.6	HGF, GPT, F2, SLC17A5
13	fatty acid⁴⁴	10.6	OTC, SLC17A5, GK, HGF
14	vitamin-e⁴⁴	10.6	HGF, F7, EIF2AK3, GPT, SLC17A5
15	phenobarbital⁴⁴ ²⁸ ¹¹	12.6	ALAS1, TSPO, SLC17A5, GPT, HGF
16	5-hydroxytryptophol⁴⁴	10.6	SLC17A5, GPT
17	ccl4⁴⁴ ²⁸	11.6	HGF, CCL20, AFP, GPT, SLC17A5
18	valproic acid⁴⁴ ⁴⁹ ¹¹ ²⁴	13.6	TSPO, OTC, SLC17A5, GPT
19	acetaminophen⁴⁴ ² ⁴⁹ ¹¹ ²⁴	14.6	GC, HGF, AFP, GPT, F2, SLC17A5
20	urea⁴⁴ ¹¹ ²⁴	12.6	GC, AFP, GPT, SLC17A5, OTC
21	glucose⁴⁴	10.6	GK, FST, SLC17A5, OTC, GTF3A
22	pyruvate⁴⁴	10.6	OTC, SLC17A5, GPT, GK, HGF
23	methotrexate⁴⁴ ⁴⁹ ¹¹	12.6	HGF, AFP, GPT, F2, SLC17A5
24	serine⁴⁴	10.6	GTF3A, SEPSECS, FGL2, F7, AFP
25	simvastatin⁴⁴ ⁴⁹ ⁵⁹ ²⁸ ¹¹ ²⁴	15.5	SLC17A5, F2, GPT, AFP
26	cyclosporin a⁴⁴ ²⁸ ⁵⁹	12.5	HGF, GPT, F2, SLC17A5, SEPSECS, TSPO
27	thyroxine⁴⁴ ²⁴	11.5	GC, AFP, GPT, SLC17A5
28	disulfiram⁴⁴ ⁵⁹ ¹¹	12.5	GPT, SLC17A5, TSPO
29	hyaluronic acid⁴⁴ ²⁴	11.5	SLC17A5, F2, GPT, HGF
30	phosphorus⁴⁴	10.5	SLC17A5, GPT, GC
31	alpha-hydroxybutyrate⁴⁴	10.5	SLC17A5, GPT
32	silymarin⁴⁴	10.5	GPT, F2, SLC17A5
33	glycogen⁴⁴ ²⁴	11.5	HGF, AFP, GPT, SLC17A5, OTC
34	lactate⁴⁴	10.5	HGF, AFP, GPT, F2, FST, SLC17A5
35	iron⁴⁴ ²⁴	11.4	CCL20, AFP, CD163, GPT, SLC17A5, ALAS1
36	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	13.4	GC, HGF, AFP, FST, SLC17A5, TSPO
37	fibrinogen⁴⁴	10.4	GC, GTF3A, SLC17A5, F2, GPT, FGL2
38	glutamine⁴⁴	10.4	HGF, AFP, EIF2AK3, GPT, LECT2, SLC17A5
39	valproate⁴⁴	10.4	GPT, SLC17A5, OTC
40	aspartate⁴⁴	10.4	F2, GPT, EIF2AK3, F7, AFP, HGF
41	steroid⁴⁴	10.4	GC, AFP, FST, SEPSECS, GTF3A, TSPO
42	atp⁴⁴ ²⁸	11.4	HGF, GK, EIF2AK3, FST, SLC17A5, OTC
43	pyridoxal 5-phosphate⁴⁴	10.4	GPT, SLC17A5, ALAS1
44	lipid⁴⁴	10.3	GC, HGF, GK, AFP, CD163, F7
45	alanine⁴⁴	10.3	HGF, CCL20, AFP, EIF2AK3, GPT, F2
46	creatinine⁴⁴	10.3	TSPO, GC, HGF, GK, AFP, F7
47	glycerol⁴⁴ ¹¹ ²⁴	12.2	TSPO, OTC, EIF2AK3, GK
48	Pyridoxal Phosphate¹¹	10.2	GPT, SEPSECS, ALAS1
49	nitric oxide⁴⁴ ¹¹ ²⁴	12.1	F7, EIF2AK3, FST, SLC17A5, OTC, CCL20
50	calcium⁴⁴ ⁴⁹ ¹¹ ²⁴	12.6	GC, HGF, CCL20, AFP, CD163, F7

GO Terms for genes affiliated with Acute Liver Failure

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	10.0	HGF, CCL20, CD163, F7, F2, FST
2	extracellular space	GO:005615	9.7	F2, GC, HGF, CCL20, AFP, F7

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of blood coagulation	GO:030194	10.4	F2, F7
2	anion transport	GO:006820	10.3	TSPO, SLC17A5
3	peptidyl-glutamic acid carboxylation	GO:017187	10.1	F2, F7