Acute Liver Failure disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Acute Liver Failure

Sources:
⁶⁴Wikipedia, ³²MalaCards
See all sources

Wikipedia:⁶⁴ Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards based summary: Acute Liver Failure, also known as hepatic failure, acute, is related to hepatitis and hepatitis a. An important gene associated with Acute Liver Failure is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). The compounds hepaplastin and aminopyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Acute Liver Failure

Sources:
³¹LifeMap Discovery®, ⁴⁴Novoseek, ⁴⁸Orphanet, ⁶¹UMLS, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet
See all sources

Acute Liver Failure, Aliases & Descriptions:

Name: Acute Liver Failure ³¹ ⁴⁴ ⁴⁸

Hepatic Failure, Acute ⁶¹

Acute Hepatic Failure ⁴⁸

Liver Failure, Acute ⁶¹

Liver Failure Acute ⁴⁴

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Liver diseases, Gastrointestinal diseases

ICD10: ²⁷

Diseases of the digestive system

Diseases of liver

Hepatic failure, not elsewhere classified

Acute and subacute hepatic failure

Characteristics (Orphanet epidemiological data):

⁴⁸

acute liver failure:
Prevalence: 1-5/10000

External Ids:

MESH via Orphanet³⁵ D017114

ICD10 via Orphanet²⁷ K72.0

UMLS via Orphanet⁶² C0162557

Related Diseases for Acute Liver Failure

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Liver Disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 143)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	31.6	F2, SEPSECS, SLC17A5
2	hepatitis a	31.4	F2
3	hepatitis b	31.1	F2, SLC17A5
4	autoimmune hepatitis	30.8	SLC17A5, SEPSECS, F2
5	alcoholic hepatitis	30.5	F2, SLC17A5
6	portal hypertension	30.5	F2, SLC17A5
7	hepatic coma	30.5	TSPO, F2
8	cholestasis	30.4	SLC17A5, F2
9	hepatitis c	30.3	F2, SLC17A5
10	viral hepatitis	30.3	SLC17A5, SEPSECS, F2
11	primary biliary cirrhosis	30.3	SLC17A5, SEPSECS, F2
12	hepatic encephalopathy	29.8	SLC17A5, GC, TSPO, AQP4, F2
13	brain edema	10.8
14	cerebritis	10.6
15	wilson disease	10.6
16	liver disease	10.5
17	herpes simplex	10.4
18	choledocholithiasis	10.4	SLC17A5
19	hepatitis e	10.4
20	liver failure acute infantile	10.4
21	spiradenoma	10.4	TSPO
22	hypertension	10.4
23	leukemia	10.4
24	endotheliitis	10.4
25	aplastic anemia	10.3
26	hemophagocytic lymphohistiocytosis	10.3
27	cholangitis	10.3	SLC17A5, SEPSECS
28	21-hydroxylase deficiency	10.3	SLC17A5, SEPSECS
29	bilirubin metabolic disorder	10.3	F2, SLC17A5
30	alcoholic liver cirrhosis	10.2	SLC17A5, F2
31	adult t-cell leukemia	10.2
32	peripheral t-cell lymphoma	10.2
33	leptospirosis	10.2
34	adult-onset still's disease	10.2
35	polyarteritis nodosa	10.2
36	hypophosphatemia	10.2
37	amyloidosis	10.2
38	breast cancer	10.2
39	intracranial hypertension	10.2
40	lactic acidosis	10.2
41	pancreatitis	10.2
42	porphyria	10.2
43	t-cell leukemia	10.2
44	macrophage activation syndrome	10.2
45	neonatal herpes	10.2
46	patent ductus venosus	10.2
47	sepsis	10.2
48	leukopenia	10.2	SLC17A5, F2
49	galactosemia	10.2	SLC17A5, F2
50	stroke, ischemic	10.1	AQP4, F2

Graphical network of the top 20 diseases related to Acute Liver Failure:

Symptoms for Acute Liver Failure

Drugs & Therapeutics for Acute Liver Failure

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ³¹LifeMap Discovery®, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:

The database of embryonic development, stem cell research and regenerative medicine

Read about Acute Liver Failure cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Acute Liver Failure:

	Hepatocyte transplantation for treatment of liver disorders
	Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases

Embryonic/Adult Cultured Cells Related to Acute Liver Failure:

	Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
	Hepatocytes

Genetic Tests for Acute Liver Failure

Anatomical Context for Acute Liver Failure

Sources:
³¹LifeMap Discovery®, ³²MalaCards
See all sources

MalaCards organs/tissues related to Acute Liver Failure:

³²

Liver, Brain, Testes, Kidney, T cells, Neutrophil, Bone marrow, Bone, Breast, Endothelial, Heart, Lung, Monocytes, Pancreas, B cells, Skeletal muscle

The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:

id	TissueAnatomical CompartmentCell	Relevance
1	LiverLiver LobuleHepatocytes	Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Acute Liver Failure:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	7.7	SLC17A5, GC, AQP4, GK, F2

Publications for Acute Liver Failure

Sources:
⁵¹PubMed
See all sources

Articles related to Acute Liver Failure:

(show top 50) (show all 649)

id	Title	Authors	Year
1	Paracetamol-associated acute liver failure in Australian and New Zealand children: high rate of medication errors. (25228327)	Rajanayagam J.... Evans H.M.	2014
2	L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. (25258408)	Kristiansen R.G.... MA	2014
3	Management of acute liver failure in infants and children: consensus statement of the pediatric gastroenterology chapter, Indian academy of pediatrics. (23778727)	.... Yachha S.K.	2013
4	TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. (23532086)	Chen F.... Nguyen J.H.	2013
5	Serum Testosterone Levels and Androgen Receptor CAG Polymorphism Correlate with Hepatitis B Virus (HBV)-Related Acute Liver Failure in Male HBV Carriers. (24391916)	Xu B.Y.... Deng G.H.	2013
6	Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. (23489904)	YtrebA... Rose C.F.	2013
7	Letter: treatment of autoimmune acute liver failure--beyond consensus guidelines; author's reply. (24099481)	Czaja A.J.	2013
8	Radiologic and Histologic Heterogeneity in a Case of AutoimmuneA Acute Liver Failure. (23962551)	Fujiwara K.... Yokosuka O.	2013
9	Acute liver failure associated with levetiracetam and lacosamide combination treatment for unspecified epileptic disorder. (24027645)	GutiAcrrez-Grobe Y.... GonzA!lez-Chon O.	2013
10	Intraoperative predictors of short-term mortality in living donor liver transplantation due to acute liver failure. (23375307)	Chung H.S.... Park C.S.	2013
11	Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. (24164805)	Habib M.... Arya R.	2013
12	Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. (23166746)	Chastre A.... Butterworth R.F.	2012
13	Lipopolysaccharide binding protein is down-regulated during acute liver failure. (22278340)	Su G.L.... Wang S.C.	2012
14	Neurological complications of acute liver failure: pathophysiological basis of current management and emerging therapies. (22100567)	Mpabanzi L.... Jalan R.	2012
15	Neutrophil CD64 expression is elevated in acetaminophen-induced acute liver failure. (23155217)	Abeles R.D.... Shawcross D.L.	2012
16	Urgent liver transplantation for nevirapine-induced acute liver failure: report of a case and review of the literature. (22466918)	Lopez-Delgado J.C.... Vicente R.G.	2012
17	Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats. (22535497)	Demirel U.... BahAsecioA9lu I.H.	2012
18	Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia. (22171136)	Miyazaki M.... Takayanagi R.	2011
19	Assessment of emergency liver transplantation criteria in acute liver failure due to Amanita phalloides. (21960294)	Ferreira R.... Sofia C.	2011
20	Effects of intraperitoneal albumin on systemic and cerebral hemodynamics in a swine model of acute liver failure. (21524179)	Tympa A.... Arkadopoulos N.	2011
21	Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)	Li C.... Wang H.F.	2011
22	Early myocardial injury is an integral component of experimental acute liver failure - a study in two porcine models. (22291759)	Papoutsidakis N.... Kostopanagiotou G.	2011
23	Invasive versus noninvasive intracranial pressure monitoring in children with acute liver failure. (22067827)	Devictor D.... Tissieres P.	2011
24	Metastatic breast cancer presenting as acute liver failure. (21346858)	Nazario H.E.... Trotter J.F.	2011
25	Bridging therapies and liver transplantation in acute liver failure, 10 years of MARS experience from Finland. (21482500)	Kantola T.... Isoniemi H.	2011
26	Case report of a successful liver transplantation for acute liver failure due to mitochondrial respiratory chain complex III deficiency. (22172894)	Iwama I.... Shimizu K.	2011
27	Acute liver failure in neonates, infants and children. (22017699)	Devictor D.... Debray D.	2011
28	Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. (21499580)	Yellapu R.K.... Schiano T.	2011
29	A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review. (21103229)	Kneiseler G.... Canbay A.	2010
30	Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)	Bienvenu A.L.... Picot S.	2010
31	Serum proinflammatory cytokines correlate with diffusion tensor imaging derived metrics and 1H-MR spectroscopy in patients with acute liver failure. (20838864)	Gupta R.K.... Saraswat V.A.	2010
32	Drug-induced acute liver failure and gastrointestinal complications. (20502172)	Lat I.... Erstad B.	2010
33	Alternative transplant procedures for acute liver failure. (21086942)	Rajput I.... Lodge J.P.	2010
34	Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation. (21168638)	Inoue K.... Yoshiba M.	2010
35	Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure. (19505222)	Singhal S.... Kar P.	2009
36	Sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure. (19954554)	Merle U.... Eisenbach C.	2009
37	A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure. (19590182)	Karvellas C.J.... Gibney R.T.	2009
38	De novo mutations in POLG presenting with acute liver failure or encephalopathy. (19252446)	Lutz R.E.... Wong L.J.	2009
39	Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case. (18609519)	Karvellas C.J.... Gibney R.T.	2008
40	Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. (18161828)	Kortsalioudaki C.... Dhawan A.	2008
41	Effects of granulocyte colony-stimulating factor on hepatocyte apoptosis in acute liver failure: experiment with rats]. (18756972)	Kang W.... Lou S.	2008
42	Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)	Blei A.T.	2007
43	Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. (17185352)	Henderson N.C.... Simpson K.J.	2007
44	Efficacy and safety of coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration for multiple organ dysfunction syndrome patients with acute liver failure]. (17207366)	He C.S.... Qin T.H.	2007
45	Caspase 8 small interfering RNA prevents acute liver failure in mice. (12810955)	Zender L.... Kubicka S.	2003
46	Glycine conjugation of para-aminobenzoic acid (PABA): a pilot study of a novel prognostic test in acute liver failure in children. (12499998)	Lebel S.... Furuya K.N.	2003
47	Living related liver transplantation for acute liver failure in children. (10226105)	Emre S.... Miller C.M.	1999
48	Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)	Suhler E.... Lee W.M.	1997
49	Acute liver failure as the initial manifestation of Wilson disease]. (7565403)	Herrmann S.... Theilmann L.	1995
50	Does hypophosphatemia play a role in acute liver failure? (2921001)	Knochel J.P.	1989

Genes related to Acute Liver Failure

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Acute Liver Failure:

- Elite gene

id	Symbol	Description	Score	Implication
1	SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	21.21	GeneCards inferred via : Publications (show sections)
2	F2	coagulation factor II (thrombin)	18.71	GeneCards inferred via : Publications (show sections)
3	TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	16.21	GeneCards inferred via : Publications (show sections)
4	SLC17A5	solute carrier family 17 (acidic sugar transporter), member 5	13.71	GeneCards inferred via : Publications (show sections)
5	AQP4	aquaporin 4	11.21	GeneCards inferred via : Publications (show sections)
6	GK	glycerol kinase	8.71	GeneCards inferred via : Publications (show sections)
7	GC	group-specific component (vitamin D binding protein)	6.21	GeneCards inferred via : Publications (show sections)
8	TSPO	translocator protein (18kDa)	3.71	GeneCards inferred via : Publications (show sections)

Products for genes related to Acute Liver Failure disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	8	-	8	8
2	Novus Biologicals	6	6	8	-

Variations for Acute Liver Failure

Expression for genes affiliated with Acute Liver Failure

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

Compounds for genes affiliated with Acute Liver Failure

Sources:
⁴⁴Novoseek, ¹²DrugBank, ⁶⁰Tocris Bioscience, ²⁹IUPHAR, ⁵⁰PharmGKB, ²⁵HMDB, ³BitterDB
See all sources

Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show all 43)

id	Compound	Score	Top Affiliating Genes
1	hepaplastin⁴⁴	10.1	SLC17A5, F2
2	aminopyrine⁴⁴	10.1	SLC17A5, F2
3	antipyrine⁴⁴ ¹²	11.0	SLC17A5, F2
4	levonorgestrel⁴⁴ ⁶⁰ ²⁹ ¹²	13.0	F2, SLC17A5
5	amiodarone⁴⁴ ⁵⁰ ²⁹ ¹²	13.0	SLC17A5, F2
6	lamivudine⁴⁴ ⁵⁰ ¹²	12.0	SLC17A5, F2
7	digoxin⁴⁴ ⁶⁰ ⁵⁰ ²⁵ ¹²	14.0	SLC17A5, F2
8	ursodeoxycholic acid⁴⁴ ²⁵ ¹²	12.0	SLC17A5, F2
9	penicillin⁴⁴	10.0	TSPO, F2
10	halothane⁴⁴ ⁵⁰ ²⁹ ¹²	13.0	SEPSECS, SLC17A5
11	silymarin⁴⁴	10.0	SLC17A5, F2
12	dipyridamole⁴⁴ ⁶⁰ ²⁹ ¹²	12.9	TSPO, F2
13	thiamine⁴⁴ ³ ²⁵ ¹²	12.9	TSPO, SLC17A5
14	isoflurane⁵⁰ ⁴⁴ ¹²	11.9	SLC17A5, TSPO
15	pge1⁴⁴	9.9	SLC17A5, F2
16	aprotinin⁴⁴ ¹²	10.8	F2, SLC17A5
17	disulfiram⁴⁴ ⁵⁰ ⁶⁰ ¹²	12.8	SLC17A5, TSPO
18	phenytoin⁴⁴ ⁵⁰ ²⁹ ¹²	12.8	TSPO, SLC17A5
19	polyethylene glycol⁴⁴	9.8	SLC17A5, F2
20	carbamazepine⁴⁴ ⁵⁰ ¹²	11.8	TSPO, SLC17A5
21	opiate⁴⁴	9.8	TSPO, SLC17A5
22	benzodiazepine⁴⁴	9.7	TSPO, GK
23	phenobarbital⁴⁴ ²⁹ ⁵⁰ ¹²	12.7	SLC17A5, TSPO
24	lidocaine⁴⁴ ²⁹ ¹²	11.6	F2, TSPO, SLC17A5
25	phosphorus⁴⁴	9.5	GC, SLC17A5
26	valproic acid⁴⁴ ⁵⁰ ²⁵ ¹²	12.5	SLC17A5, TSPO
27	rosiglitazone²⁹ ⁴⁴ ⁵⁰ ²⁵ ¹²	13.4	SLC17A5, GK
28	morphine⁴⁴ ⁵⁰ ²⁹ ¹²	12.4	TSPO, SLC17A5
29	chloride⁴⁴	9.4	AQP4, TSPO, SLC17A5
30	bicarbonate⁴⁴	9.4	GC, AQP4
31	acetaminophen⁴⁴ ³ ⁵⁰ ²⁵ ¹²	13.3	SLC17A5, GC, F2
32	norepinephrine⁴⁴ ²⁵ ¹²	11.2	GK, TSPO, SLC17A5
33	glycerol⁴⁴ ²⁵ ¹²	11.2	TSPO, AQP4, GK
34	cyclosporin a⁴⁴ ²⁹ ⁶⁰	11.2	F2, SEPSECS, TSPO, SLC17A5
35	fibrinogen⁴⁴	9.2	F2, GC, SLC17A5
36	urea⁴⁴ ²⁵ ¹²	11.1	AQP4, GC, SLC17A5
37	aspartate⁴⁴	9.1	SLC17A5, GC, F2
38	h2o2⁴⁴	9.0	GK, TSPO, SLC17A5
39	fatty acid⁴⁴	8.9	SLC17A5, GC, GK
40	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.7	SLC17A5, GC, TSPO
41	glutamate⁴⁴	8.6	AQP4, TSPO, GC, SLC17A5
42	steroid⁴⁴	8.5	GC, TSPO, SEPSECS
43	creatinine⁴⁴	8.1	SLC17A5, GC, TSPO, GK, F2

GO Terms for genes affiliated with Acute Liver Failure

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial outer membrane	GO:005741	9.3	TSPO, GK

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	anion transport	GO:006820	9.4	SLC17A5, TSPO
2	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.3	TSPO, F2
3	steroid metabolic process	GO:008202	9.1	GC, TSPO