MCID: ACT134
MIFTS: 55

Acute Liver Failure malady

Liver category

Summaries for Acute Liver Failure

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis a and hepatitis c. An important gene associated with Acute Liver Failure is F2 (coagulation factor II (thrombin)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds d-galactosamine and 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Acute Liver Failure

Sources:
31LifeMap Discovery™, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Characteristics (Orphanet epidemiological data):

49
acute liver failure:
Prevalence: 1-5/10000


Aliases & Descriptions:

acute liver failure 31 45 49
acute hepatic failure 49
liver failure, acute 61
liver failure acute 45


External Ids:

MESH via Orphanet36 D017114
ICD10 via Orphanet26 K72.0
SNOMED-CT via Orphanet58 197270009
UMLS via Orphanet62 C0162557

Related Diseases for Acute Liver Failure

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the liver disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis a31.1F2
2hepatitis c31.0AFP, GPT, F2, SLC17A5
3wilson disease30.8OTC, SLC17A5, GPT
4hepatitis e30.5GPT
5autoimmune hepatitis30.5SEPSECS
6acute pancreatitis30.2SLC17A5, GPT
7hepatitis b30.2SLC17A5, F2, GPT, FGL2, AFP
8viral hepatitis30.2AFP, FGL2, GPT, F2, SLC17A5, SEPSECS
9arthritis30.0CCL20, CD163
10tuberculosis30.0GC
11acute myocardial infarction30.0F7
12hepatic coma30.0F2, TSPO
13portal hypertension30.0GPT, F2, SLC17A5
14alcoholic liver cirrhosis30.0SLC17A5, F2, GPT
15alcoholic hepatitis30.0F2, HGF
16primary biliary cirrhosis30.0GPT, F2, SLC17A5, SEPSECS
17brain disease30.0GC, GPT, F2, SLC17A5, OTC, TSPO
18brain edema10.8
19hepatitis c virus10.6
20hepatitis d10.5
21acute kidney failure10.4
22liver failure acute infantile10.4
23liver lymphoma10.3
24acute leukemia10.3
25hemophagocytic lymphohistiocytosis10.3
26aplastic anemia10.3
27hypophosphatemia10.2
28leptospirosis10.2
29polyarteritis nodosa10.2
30acute porphyria10.2
31amyloidosis10.2
32neonatal herpes10.2
33patent ductus venosus10.2
34sepsis10.2
35graft versus host disease10.0
36cardiac tamponade10.0
37ebola hemorrhagic fever10.0
38small cell carcinoma10.0
39peliosis hepatis10.0
40diabetes insipidus10.0
41focal dermal hypoplasia10.0
42yellow fever10.0
43chorea-acanthocytosis10.0
44nephrogenic diabetes insipidus10.0
45japanese spotted fever10.0
46hepatic vein thrombosis10.0
47spotted fever10.0
48acute graft versus host disease10.0
49chronic graft versus host disease10.0
50epiphyseal dysplasia multiple with early-onset diabetes mellitus10.0

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to acute liver failure

Clinical Features for Acute Liver Failure

Drugs & Therapeutics for Acute Liver Failure

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Liver Failure

Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Search CenterWatch for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

Anatomical Context for Acute Liver Failure

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Acute Liver Failure:

33
Bone marrow, Whole blood, Brain, Heart, Skeletal muscle, Small intestine, Kidney, Liver, Lung, Pancreas, Breast, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Temporal lobe, Fetal liver, Fetal lung

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Liver Failure:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.7GK, AFP, F7, FGL2, EIF2AK3, LECT2
2MP:00107689.4ALAS1, HGF, GK, AFP, F7, FGL2

Publications for Acute Liver Failure

Sources:
51PubMed
See all sources

Articles related to Acute Liver Failure:

(show top 50)    (show all 717)
idTitleAuthorsYear
1
Specificity of an anti-capsid antibody associated with Hepatitis B Virus-related acute liver failure. (23079477)
2013
2
Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial. (22886633)
2013
3
Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chronic hepatitis B liver failure. (24366287)
2013
4
Lung Injury and Its Prognostic Significance in Acute Liver Failure. (24152589)
2013
5
The efficacy of Continuous Plasma Diafiltraion Therapy in critical Patients with Acute Liver Failure. (24224755)
2013
6
Improvements in hepatic serological biomarkers are associated with clinical benefit of intravenous N-acetylcysteine in early stage non-acetaminophen acute liver failure. (23325162)
2013
7
Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure. (23292505)
2013
8
Risk factors for invasive pulmonary aspergillosis and hospital mortality in acute-on-chronic liver failure patients: a retrospective-cohort study. (24151434)
2013
9
Rapid recovery from acute liver failure secondary to pancreatoduodenectomy-related non-alcoholic steatohepatitis. (23467319)
2013
10
Evaluation of the Hepa WashAr treatment in pigs with acute liver failure. (23668774)
2013
11
The long-term outcomes of patients transplanted due to acute liver failure with hepatic human herpesvirus-6 infection. (23769070)
2013
12
Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure 2011. (22213561)
2012
13
A novel small molecule, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5'-methyl-7,7'-dimethoxy-4,4'-bibenzo[d][1,3]dioxole-5,5'-dicarboxylate (7k), alleviates the development of D-galactosamine/lipopolysaccharide-induced acute liver failure by inhibiting macrophage infiltration and regulating cytokine expression. (22238210)
2012
14
Increased plasma levels of high mobility group box 1 in patients with acute liver failure. (22585050)
2012
15
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. (22691571)
2012
16
Successful use of intravenous N-acetylcysteine in dengue haemorrhagic fever with acute liver failure. (23292059)
2012
17
Etiologies and outcomes of acute liver failure in Germany. (22373724)
2012
18
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
19
Acute liver failure in neonates, infants and children. (22017699)
2011
20
Acute liver failure because of chronic lymphocytic leukemia: case report and review of the literature. (21331280)
2011
21
Acute liver failure: current practice and recent advances. (21893272)
2011
22
Post-traumatic stress disorders, mood disorders, and quality of life in transplant recipients with acute liver failure. (21335184)
2011
23
Changing etiologies and outcomes of acute liver failure: A perspective from Japan. (21199516)
2011
24
The analysis of IL-10 and its methylation in the patients with acute on chronic liver failure]. (21863628)
2011
25
Correlation between promoter methylation of glutathione-S-tranferase P1 and oxidative stress in acute-on-chronic hepatitis B liver failure. (21692937)
2011
26
Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. (21224054)
2011
27
Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation. (21168638)
2010
28
Xenotransplantation of hepatocytes in rats with acute liver failure using sirolimus for immunosuppression. (20515568)
2010
29
Acute liver failure caused by concurrent autoimmune hepatitis and hepatitis B in a 16-year old girl. (21160949)
2010
30
Subtle BBB alterations in brain edema associated with acute liver failure. (20201130)
2010
31
Treatment of brain edema in acute liver failure. (20842576)
2010
32
High-density lipoprotein cholesterol improves the model for end-stage liver disease scoring system for prognostic prediction of acute liver failure. (20001750)
2010
33
Liver repopulation by transplanted hepatocytes in a rat model of acute liver failure induced by carbon tetrachloride and a partial hepatectomy. (21183876)
2010
34
The effect of Prometheus device on laboratory markers of inflammation and tissue regeneration in acute liver failure management. (21094824)
2010
35
Meta-analysis of performance of Kings's College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure. (20580460)
2010
36
Systematic review: prognostic tests of paracetamol-induced acute liver failure. (20180786)
2010
37
Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure. (19505222)
2009
38
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. (19439490)
2009
39
Acute liver failure in Lithuania. (18695350)
2008
40
TIPS can be lifesaving in acute liver failure associated with portal vein and inferior vena cava thrombosis in a case of Budd Chiari syndrome due to protein S deficiency. (18046604)
2008
41
Efficacy and safety of coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration for multiple organ dysfunction syndrome patients with acute liver failure]. (17207366)
2007
42
Fulminant liver failure from acute autochthonous hepatitis E in France: description of seven patients with acute hepatitis E and encephalopathy. (17439518)
2007
43
Molecular adsorbent recirculating system dialysis in patients with acute liver failure who are assessed for liver transplantation. (16941171)
2006
44
Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure. (15912107)
2005
45
Extracorporeal albumin dialysis in acute-on-chronic liver failure: will it stand the test of time? (12297853)
2002
46
Hepatocyte transplantation in acute liver failure. (10648575)
2000
47
Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. (10733542)
2000
48
Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure. (10516999)
1999
49
Acute liver failure as the initial manifestation of Wilson disease]. (7565403)
1995
50
Does hypophosphatemia play a role in acute liver failure? (2921001)
1989

Genetic Variations for Acute Liver Failure

Expression for genes affiliated with Acute Liver Failure

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Acute Liver Failure

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1d-galactosamine4510.7HGF, GPT, SLC17A5
25-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)1110.7F2, F7
3aminopyrine4510.7GPT, F2, SLC17A5
4hepaplastin4510.7HGF, GPT, F2, SLC17A5
5lamivudine45 1111.7SLC17A5, F2
6lidocaine45 29 1112.7TSPO, SLC17A5, F2, HGF
7ursodeoxycholic acid45 11 2412.7HGF, GPT, F2, SLC17A5
8levonorgestrel45 60 29 1113.7F7, F2, SLC17A5
9isoflurane45 1111.6TSPO, SLC17A5, GPT
10vitamin a45 11 2412.6GC, HGF, FST, GTF3A
11glutamate4510.6GPT, LECT2, OTC, TSPO
12pge14510.6HGF, GPT, F2, SLC17A5
13fatty acid4510.6OTC, SLC17A5, GK, HGF
14vitamin-e4510.6HGF, F7, EIF2AK3, GPT, SLC17A5
15phenobarbital45 29 1112.6ALAS1, TSPO, SLC17A5, GPT, HGF
165-hydroxytryptophol4510.6SLC17A5, GPT
17ccl445 2911.6HGF, CCL20, AFP, GPT, SLC17A5
18valproic acid45 50 11 2413.6TSPO, OTC, SLC17A5, GPT
19acetaminophen45 2 50 11 2414.6GC, HGF, AFP, GPT, F2, SLC17A5
20urea45 11 2412.6GC, AFP, GPT, SLC17A5, OTC
21glucose4510.6GK, FST, SLC17A5, OTC, GTF3A
22pyruvate4510.6OTC, SLC17A5, GPT, GK, HGF
23methotrexate45 50 1112.6HGF, AFP, GPT, F2, SLC17A5
24serine4510.6GTF3A, SEPSECS, FGL2, F7, AFP
25simvastatin45 50 60 29 11 2415.5SLC17A5, F2, GPT, AFP
26cyclosporin a45 29 6012.5HGF, GPT, F2, SLC17A5, SEPSECS, TSPO
27thyroxine45 2411.5GC, AFP, GPT, SLC17A5
28disulfiram45 60 1112.5GPT, SLC17A5, TSPO
29hyaluronic acid45 2411.5SLC17A5, F2, GPT, HGF
30phosphorus4510.5SLC17A5, GPT, GC
31alpha-hydroxybutyrate4510.5SLC17A5, GPT
32silymarin4510.5GPT, F2, SLC17A5
33glycogen45 2411.5HGF, AFP, GPT, SLC17A5, OTC
34lactate4510.5HGF, AFP, GPT, F2, FST, SLC17A5
35iron45 2411.4CCL20, AFP, CD163, GPT, SLC17A5, ALAS1
36testosterone45 60 11 2413.4GC, HGF, AFP, FST, SLC17A5, TSPO
37fibrinogen4510.4GC, GTF3A, SLC17A5, F2, GPT, FGL2
38glutamine4510.4HGF, AFP, EIF2AK3, GPT, LECT2, SLC17A5
39valproate4510.4GPT, SLC17A5, OTC
40aspartate4510.4F2, GPT, EIF2AK3, F7, AFP, HGF
41steroid4510.4GC, AFP, FST, SEPSECS, GTF3A, TSPO
42atp45 2911.4HGF, GK, EIF2AK3, FST, SLC17A5, OTC
43pyridoxal 5-phosphate4510.4GPT, SLC17A5, ALAS1
44lipid4510.3GC, HGF, GK, AFP, CD163, F7
45alanine4510.3HGF, CCL20, AFP, EIF2AK3, GPT, F2
46creatinine4510.3TSPO, GC, HGF, GK, AFP, F7
47glycerol45 11 2412.2TSPO, OTC, EIF2AK3, GK
48Pyridoxal Phosphate1110.2GPT, SEPSECS, ALAS1
49nitric oxide45 11 2412.1F7, EIF2AK3, FST, SLC17A5, OTC, CCL20
50calcium45 50 11 2412.6GC, HGF, CCL20, AFP, CD163, F7

GO Terms for genes affiliated with Acute Liver Failure

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0HGF, CCL20, CD163, F7, F2, FST
2extracellular spaceGO:0056159.7F2, GC, HGF, CCL20, AFP, F7

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:03019410.4F2, F7
2anion transportGO:00682010.3TSPO, SLC17A5
3peptidyl-glutamic acid carboxylationGO:01718710.1F2, F7

Molecular functions related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.3ALAS1, SEPSECS, GPT

Products for genes affiliated with Acute Liver Failure

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Liver Failure

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet