MCID: ACT134
MIFTS: 48

Acute Liver Failure

Categories: Liver diseases, Rare diseases, Genetic diseases, Metabolic diseases, Gastrointestinal diseases

Aliases & Classifications for Acute Liver Failure

MalaCards integrated aliases for Acute Liver Failure:

Name: Acute Liver Failure 38 56 52
Acute Hepatic Failure 56 29
Fulminant Hepatic Failure 56
Hepatic Failure Fulminant 52
Liver Failure, Acute 69
Liver Failure Acute 52

Characteristics:

Orphanet epidemiological data:

56
acute liver failure
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 56  
Rare hepatic diseases


External Ids:

Orphanet 56 ORPHA90062
MESH via Orphanet 43 D017114
UMLS via Orphanet 70 C0162557
ICD10 via Orphanet 34 K72.0

Summaries for Acute Liver Failure

MalaCards based summary : Acute Liver Failure, also known as acute hepatic failure, is related to liver failure, transient infantile and wolcott-rallison syndrome. An important gene associated with Acute Liver Failure is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and brain.

Wikipedia : 72 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

Related Diseases for Acute Liver Failure

Diseases in the Liver Disease family:

Infantile Liver Failure Syndrome 2 Infantile Liver Failure Syndrome 1
Liver Failure, Transient Infantile Acute Liver Failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
id Related Disease Score Top Affiliating Genes
1 liver failure, transient infantile 11.3
2 wolcott-rallison syndrome 11.2
3 hepatitis 11.2
4 ruijs-aalfs syndrome 11.0
5 infantile liver failure syndrome 2 10.9
6 infantile liver failure syndrome 1 10.8
7 mitochondrial dna depletion syndrome 4a 10.8
8 argyria 10.6 F2 GPT
9 maxillary sinusitis 10.6 F2 GPT
10 htra1-related autosomal dominant cerebral small vessel disease 10.6 GPT SLC17A5
11 quinquaud's decalvans folliculitis 10.6 GPT SLC17A5
12 megaloblastic anemia 10.5 GPT SLC17A5
13 hypertrophy of breast 10.4 NBAS TSPO
14 non-hodgkin lymphoma, during pregnancy 10.4 ALB F2
15 nonsyndromic hereditary sensorineural hearing loss 10.4 GPT SLC17A5
16 fragile x syndrome type 2 10.4 ALB F2
17 oral cavity carcinoma in situ 10.4 ALB F2
18 chronic inflammatory demyelinating polyneuritis 10.3 ALB F2
19 angelucci's syndrome 10.3 ALB F2
20 atrophic vulva 10.3 ALB F2
21 childhood brain stem glioma 10.3 ALB F2
22 myopia 10.3 ALB F2
23 capillary hemangioma 10.3 ALB F2
24 nephrocalcinosis 10.3 ALB GC
25 common cold 10.2 ALB SLC17A5
26 brain edema 10.2
27 bladder sarcoma 10.2 ALB GPT
28 cataract 10.2 ALB HGF
29 syncope 10.2 F2 F5
30 lockwood feingold syndrome 10.2 F2 F5
31 superior limbic keratoconjunctivitis 10.2 F2 F5
32 hereditary ataxia 10.2 F2 GPT SLC17A5
33 46,xy ovotesticular disorder of sex development 10.2 F2 F5
34 follicular adenoma 10.2 F2 F5
35 ischemic heart disease 10.2 ALB F2
36 testicular gonadoblastoma 10.2 F2 F5
37 bile duct cystadenoma 10.2 F2 F5
38 collagenous colitis 10.2 F2 F5
39 hiv-1 10.2 F2 F5
40 glutathioninuria 10.1 F2 F5
41 late yaws 10.1 ALB SLC17A5
42 primary pigmented nodular adrenocortical disease 10.1 F2 F5
43 rheumatoid lung disease 10.1 F2 F5
44 facioscapulohumeral muscular dystrophy 1 10.1 F2 F5
45 cryptosporidiosis 10.1 F2 F5
46 factor v deficiency 10.1 F2 F5
47 intestinal pseudo-obstruction 10.1 F2 F5
48 congenital syphilis 10.1 F2 F5
49 homologous wasting disease 10.1 F2 F5
50 idiopathic juvenile osteoporosis 10.1 ALB HGF

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to Acute Liver Failure

Symptoms & Phenotypes for Acute Liver Failure

Drugs & Therapeutics for Acute Liver Failure

Drugs for Acute Liver Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
4
Lenograstim Approved Phase 4,Phase 3 135968-09-1
5
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
6
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
7
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351
8
Entecavir Approved, Investigational Phase 4,Phase 2 142217-69-4 153941
9
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
11 Antifungal Agents Phase 4
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2
13 Echinocandins Phase 4
14 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
15 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2
16 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
17 Antiemetics Phase 4
18 Anti-Inflammatory Agents Phase 4,Phase 2
19 Antineoplastic Agents, Hormonal Phase 4,Phase 2
20 Autonomic Agents Phase 4
21 Gastrointestinal Agents Phase 4,Phase 2
22 glucocorticoids Phase 4,Phase 2
23 Hormone Antagonists Phase 4,Phase 2
24 Hormones Phase 4,Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
26 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
27 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2
28 Adjuvants, Immunologic Phase 4,Phase 3
29 Antidotes Phase 4,Phase 3
30 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2
31 Expectorants Phase 4,Phase 3
32 N-monoacetylcystine Phase 4,Phase 3
33 Respiratory System Agents Phase 4,Phase 3
34 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
35 Anti-HIV Agents Phase 4
36 Anti-Retroviral Agents Phase 4
37 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
38 Reverse Transcriptase Inhibitors Phase 4
39
Tenofovir Phase 4 147127-20-6 464205
40 gamma-Globulins Phase 4
41 Immunoglobulins, Intravenous Phase 4
42 Rho(D) Immune Globulin Phase 4
43 Anticoagulants Phase 4,Phase 3
44 calcium heparin Phase 4
45 Calcium, Dietary Phase 4
46 Chelating Agents Phase 4
47 Dialysis Solutions Phase 4,Phase 2,Phase 3
48 Fibrinolytic Agents Phase 4
49 Antimetabolites Phase 4,Phase 2
50 Methylprednisolone acetate Phase 4

Interventional clinical trials:

(show top 50) (show all 132)

id Name Status NCT ID Phase Drugs
1 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Unknown status NCT01968395 Phase 4 Caspofungin 70 mg
2 A Randomized Controlled Trial of Lamivudine in Acute Hepatitis B Completed NCT00380614 Phase 4 Lamivudine
3 Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure Completed NCT01074645 Phase 4 Tenofovir disoproxil fumarate (TDF)
4 Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure" Completed NCT01201720 Phase 4
5 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
6 Steroids in Fulminant Hepatic Failure in the Pediatric Age Group Recruiting NCT02375867 Phase 4 prednisolone;methylprednisolone
7 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Recruiting NCT02757170 Phase 4
8 RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure Recruiting NCT02331745 Phase 4 Granulocyte colony-stimulating factor;standard treatment
9 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4 N-acetylcysteine
10 Minocycline Administration During Human Liver Transplantation Withdrawn NCT02712775 Phase 4 Minocycline (yes/no);Placebo
11 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
12 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Completed NCT00004467 Phase 3 N-acetylcysteine (NAC);Placebo
13 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3 Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO);Placebo
14 The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Completed NCT00224705 Phase 3
15 Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure Completed NCT01471028 Phase 3
16 13C-Methacetin Breath Test for the Prediction of Outcome in ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-methacetin
17 Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction Recruiting NCT02837939 Phase 2, Phase 3 Human derived Transfer factor;Aqua pro injectione 4ml ampules for subcutaneous injection
18 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Recruiting NCT02612428 Phase 3
19 Evaluation of the Effect of Gabexate Mesilate in the Hepatocyte Protection After Liver Resection Recruiting NCT02710266 Phase 3 Preoperative Gabexate Mesilate group;Intraoperative Gabexate Mesilate group;hepatectomy with dextrose water
20 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
21 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
22 Cardiox Liver Function Test Pivotal Trial Withdrawn NCT02552901 Phase 3 0.1 mg/kg ICG Dose;0.5 mg/kg ICG dose
23 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
24 Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure Unknown status NCT01318525 Phase 2 ALF-5755;Saline solution (0.9% NaCl)
25 Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure Unknown status NCT00225901 Phase 1, Phase 2 Recombinant human hepatocyte growth factor
26 Umbilical Cord Mesenchymal Stem Cells Transplantation Combined With Plasma Exchange for Patients With Liver Failure Unknown status NCT01724398 Phase 1, Phase 2
27 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
28 Emergency Use of OCR-002 in Acute Liver Failure Completed NCT01634230 Phase 2 OCR-002
29 Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure Completed NCT00030225 Phase 2
30 Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency Completed NCT00771446 Phase 1, Phase 2
31 The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure Completed NCT01254994 Phase 2 entecavir;Traditional comprehensive medical treatment
32 Single Pass Albumin Dialysis in Patients With Cirrhosis Completed NCT00764049 Phase 1, Phase 2
33 Low Dose IL-2, Hematopoietic Stem Cell Transplantation, IL2 for GVHD Completed NCT00539695 Phase 2
34 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Recruiting NCT01548690 Phase 2 Ornithine phenylacetate
35 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Recruiting NCT01690845 Phase 2
36 Phase II Safety Study of 2 Dose Regimens of HepaStem in Patients With ACLF Recruiting NCT02946554 Phase 2
37 A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virus Recruiting NCT01698723 Phase 2 Ribavirin;Placebo
38 A Randomized Controlled Clinical Trial of Thymoglobulin® After Liver Transplantation Recruiting NCT02544113 Phase 2 Thymoglobulin;Placebo
39 Pneumatic Reversible Portal Vein Diameter Modulation After Major Hepatectomy Recruiting NCT02390713 Phase 1, Phase 2
40 Safety and Efficacy of ProQuad® in Children 6-24 Month Being Evaluated for Solid Organ Transplant Recruiting NCT02687763 Phase 1, Phase 2
41 T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts Recruiting NCT00368355 Phase 2 Ara-C;Cyclophosphamide
42 Effects of Rifaximin in Patients With Acute Alcoholic Hepatitis Enrolling by invitation NCT02116556 Phase 2 Prednisone;Rifaximin
43 UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver Failure Not yet recruiting NCT02812121 Phase 2 umbilical cord blood mesenchymal stem cells
44 Safety and Efficacy of ELAD to Treat Acute Liver Failure (ALF) Terminated NCT01875874 Phase 2
45 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
46 Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) Withdrawn NCT00832728 Phase 2
47 Hepatocyte Transplantation in Liver Failure Withdrawn NCT00805610 Phase 1, Phase 2
48 Allogenic Bone Marrow Mesenchymal Stem Cell Therapy in Acute-on-chronic Liver Failure Recruiting NCT02857010 Phase 1
49 Hepatocyte Transplantation for Acute Decompensated Liver Failure Suspended NCT01345565 Phase 1 human hepatocytes
50 A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome Terminated NCT01906307 Phase 1 LJPC-501

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.

Genetic Tests for Acute Liver Failure

Genetic tests related to Acute Liver Failure:

id Genetic test Affiliating Genes
1 Acute Hepatic Failure 29

Anatomical Context for Acute Liver Failure

MalaCards organs/tissues related to Acute Liver Failure:

39
Liver, Brain, Testes, T Cells, Bone, Bone Marrow, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Potential therapeutic candidate, affected by disease

Publications for Acute Liver Failure

Articles related to Acute Liver Failure:

(show top 50) (show all 796)
id Title Authors Year
1
Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease? ( 28914695 )
2017
2
Endoplasmic reticulum stress restrains hepatocyte growth factor expression in hepatic stellate cells and rat acute liver failure model. ( 28844859 )
2017
3
Acute liver failure induced by idiosyncratic reaction to drugs: Challenges in diagnosis and therapy. ( 28771932 )
2017
4
Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure. ( 28088395 )
2017
5
Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab. ( 28948184 )
2017
6
Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure. ( 28859230 )
2017
7
Association of Mutations in Toll-like Receptor 2 Signaling Genes With Fulminant Form of Hepatitis B-Related Acute Liver Failure. ( 28329297 )
2017
8
Peak hyperammonemia and atypical acute liver failure: the eruption of an urea cycle disorder during hyperemesis gravidarum. ( 28939132 )
2017
9
Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure. ( 28787384 )
2017
10
Protective role of hypoxia-inducible factor-1I+-dependent CD39 and CD73 in fulminant acute liver failure. ( 27899277 )
2017
11
Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment. ( 28809737 )
2017
12
Appropriate timing to start and optimal response evaluation of high-dose corticosteroid therapy for patients with acute liver failure. ( 28078470 )
2017
13
Acute Liver Failure in a Patient Travelling From Asia: The Other Face of the Coin of Infectious Disease. ( 28912916 )
2017
14
Interleukin-10 secreted by mesenchymal stem cells attenuates acute liver failure through inhibiting pyroptosis. ( 28833919 )
2017
15
Liver transplantation is associated with good clinical outcome in patients with active tuberculosis and acute liver failure due to anti-tubercular treatment. ( 28054732 )
2017
16
Identifying Brain Dysfunction Among Children With Acute Liver Failure-Can Spectral Electroencephalography Help? ( 28060158 )
2017
17
NBAS mutations cause acute liver failure: when acetaminophen is not a culprit. ( 28946922 )
2017
18
Is dengue emerging as important cause of acute liver failure in endemic regions? ( 28798927 )
2017
19
Psychosocial and behavioral factors in acetaminophen-related acute liver failure and liver injury. ( 28867424 )
2017
20
Predictors of infection in viral-hepatitis related acute liver failure. ( 28875762 )
2017
21
Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype. ( 28031453 )
2017
22
Decreased activity of plasma ADAMTS13 are related to enhanced cytokinemia and endotoxemia in patients with acute liver failure. ( 28894574 )
2017
23
Budd-chiari syndrome and acute liver failure: A complex condition requiring a rapid response. ( 28006871 )
2017
24
Dengue Hemorrhagic Fever: ARare Cause of Acute Liver Failure. ( 28903847 )
2017
25
High ferritin concentration in acute liver failure: the top of the iceberg? ( 28941305 )
2017
26
Acute Liver Failure due to Trazodone and Diazepam. ( 28848778 )
2017
27
Good outcome of living donor liver transplantation in drug induced acute liver failure: a single centre experience. ( 28054388 )
2017
28
American Gastroenterological Association Institute Guidelines for the Diagnosis and Management of Acute Liver Failure. ( 28056348 )
2017
29
Exertional Heat Illness Resulting in Acute Liver Failure and Liver Transplantation. ( 28910461 )
2017
30
Predicting Fluid Responsiveness in Acute Liver Failure: A Prospective Study. ( 27984249 )
2017
31
Slow ventricular tachycardia presenting with acute liver failure. ( 28835821 )
2017
32
C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure. ( 28028363 )
2016
33
Development of a Model to Predict Transplant-free Survival of Patients with Acute Liver Failure. ( 27085756 )
2016
34
Plasma exchange and chelator therapy rescues acute liver failure in Wilson disease without liver transplantation. ( 27007780 )
2016
35
Encapsulated platelets modulate Kupffer cell activation and reduce oxidative stress in a model of acute liver failure. ( 27509591 )
2016
36
N-Acetylcysteine Use in Non-Acetaminophen-Induced Acute Liver Failure. ( 27482990 )
2016
37
Transplantation of Adipose-Derived Mesenchymal Stem Cells Efficiently Rescues Thioacetamide-Induced Acute Liver Failure in Mice. ( 27569972 )
2016
38
Intracerebral Administration of S-Adenosylhomocysteine or S-Adenosylmethionine Attenuates the Increases in the Cortical Extracellular Levels of Dimethylarginines Without Affecting cGMP Level in Rats with Acute Liver Failure. ( 27604291 )
2016
39
Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A virus: no evidence of the co-infection as a cause of acute liver failure. ( 27074255 )
2016
40
Combined treatment with MSC transplantation and neutrophil depletion ameliorates D-GalN/LPS-induced acute liver failure in rats. ( 27637473 )
2016
41
Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure. ( 27057357 )
2016
42
Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study. ( 27043883 )
2016
43
Liver transplantation for acute liver failure accompanied by severe acute pancreatitis. ( 27600056 )
2016
44
Acute liver failure impairs function and expression of breast cancer resistant protein (BCRP) at rat blood-brain barrier partly via ammonia-ROS-ERK1/2 activation. ( 27168176 )
2016
45
Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure. ( 27496798 )
2016
46
Liver Transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis. ( 27216884 )
2016
47
Tamoxifen Attenuates Lipopolysaccharide/Galactosamine-induced Acute Liver Failure by Antagonizing Hepatic Inflammation and Apoptosis. ( 27967264 )
2016
48
Aetiology and Outcome of Acute Liver Failure in Children: Experience at a Tertiary Care Hospital of Bangladesh. ( 27612896 )
2016
49
Incidence of Primary Mitochondrial Disease in Children Presenting With Acute Liver Failure Under 2 Years of Age. ( 27482763 )
2016
50
Sequential analysis of variable markers for predicting outcomes in pediatric patients with acute liver failure. ( 28032939 )
2016

Variations for Acute Liver Failure

ClinVar genetic disease variations for Acute Liver Failure:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh37 Chromosome 17, 62492543: 62492543

Expression for Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for Acute Liver Failure

Pathways related to Acute Liver Failure according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.27 ALB F2

GO Terms for Acute Liver Failure

Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ALB F2 F5 GC GPT HGF
2 blood microparticle GO:0072562 9.33 ALB F2 GC
3 platelet alpha granule lumen GO:0031093 8.8 ALB F5 HGF

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB F2 F5
2 positive regulation of reactive oxygen species metabolic process GO:2000379 9.16 F2 TSPO
3 anion transport GO:0006820 8.96 SLC17A5 TSPO
4 platelet degranulation GO:0002576 8.8 ALB F5 HGF

Sources for Acute Liver Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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