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MCID: ACT134
MIFTS: 50

Acute Liver Failure malady

Categories: Liver diseases, Rare diseases, Genetic diseases, Metabolic diseases, Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acute Liver Failure

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Aliases & Descriptions for Acute Liver Failure:

Name: Acute Liver Failure 38 56 52
Acute Hepatic Failure 56 29
Fulminant Hepatic Failure 56
Hepatic Failure Fulminant 52
Liver Failure, Acute 69
Liver Failure Acute 52

Characteristics:

Orphanet epidemiological data:

56
acute liver failure
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Metabolic diseases
Anatomical: Liver diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 56  
Rare hepatic diseases


External Ids:

Orphanet 56 ORPHA90062
MESH via Orphanet 43 D017114
UMLS via Orphanet 70 C0162557
ICD10 via Orphanet 34 K72.0
Sources

Summaries for Acute Liver Failure

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MalaCards based summary : Acute Liver Failure, also known as acute hepatic failure, is related to liver failure, transient infantile and hepatitis. An important gene associated with Acute Liver Failure is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and brain.

Wikipedia : 71 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

Sources

Related Diseases for Acute Liver Failure

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Diseases in the Liver Disease family:

Infantile Liver Failure Syndrome 2 Infantile Liver Failure Syndrome 1
Liver Failure, Transient Infantile Acute Liver Failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
id Related Disease Score Top Affiliating Genes
1 liver failure, transient infantile 11.3
2 hepatitis 11.2
3 ruijs-aalfs syndrome 11.0
4 infantile liver failure syndrome 2 10.9
5 mitochondrial dna depletion syndrome 4a 10.8
6 infantile liver failure syndrome 1 10.8
7 familial progressive hyperpigmentation 10.2 F2 GPT
8 maxillary sinusitis 10.2 F2 GPT
9 brain edema 10.2
10 congenital insensitivity to pain with severe intellectual disability 10.2 F2 GC
11 gastric neuroendocrine tumor type 1 10.2 GPT SLC17A5
12 radiation induced cancer 10.2 GPT SLC17A5
13 pulpitis 10.2 F2 SLC17A5
14 megaloblastic anemia 10.2 GPT SLC17A5
15 nondystrophic myotonia 10.2 ALB F2
16 freiberg's disease 10.1 ALB F2
17 pharynx carcinoma in situ 10.1 ALB F2
18 chronic inflammatory demyelinating polyneuritis 10.1 ALB F2
19 angelucci's syndrome 10.1 ALB F2
20 ovarian papillary cystadenoma 10.1 ALB F2
21 myopia 10.1 ALB F2
22 eagle syndrome 10.1 ALB F2
23 atrophic vulva 10.1 ALB F2
24 acute proliferative glomerulonephritis 10.1 F2 GPT SLC17A5
25 nephrocalcinosis 10.1 ALB GC
26 encephalopathy 10.1
27 hereditary hemorrhagic telangiectasia 10.1 F2 GPT SLC17A5
28 mastitis 10.0 NBAS TSPO
29 wilson disease 10.0
30 cataract 10.0 ALB HGF
31 capillary hemangioma 10.0 ALB F2
32 isolated growth hormone deficiency 10.0 ALB GPT
33 bladder sarcoma 10.0 ALB GPT
34 bile duct cystadenocarcinoma 10.0 ALB F2 GPT
35 benign deep fibrous histiocytoma 10.0 ALB F2 GPT
36 hemolytic-uremic syndrome 10.0 ALB F2 GPT
37 pyelitis 10.0 ALB F2 GPT
38 not otherwise specified 3-mga-uria type 10.0 GPT SLC17A5
39 fallopian tube leiomyosarcoma 10.0 ALB F2 GPT
40 gastrointestinal adenoma 10.0 ALB F2 GPT
41 hepatitis b 10.0
42 cerebritis 10.0
43 fiedler's myocarditis 10.0 ALB F2 GPT
44 infiltrating ureter transitional cell carcinoma 10.0 ALB F2 SLC17A5
45 bacterial meningitis 10.0 ALB F2 GPT
46 ischemic optic neuropathy 10.0 ALB F2
47 anal fistula 10.0 ALB F2 SLC17A5
48 idiopathic juvenile osteoporosis 10.0 ALB HGF
49 rosacea 10.0 ALB GPT SLC17A5
50 duane retraction syndrome 10.0 ALB F2 TSPO

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to Acute Liver Failure
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Symptoms & Phenotypes for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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Drugs for Acute Liver Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 367)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
3
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
4
Somatostatin Approved Phase 4,Phase 3 38916-34-6, 51110-01-1 53481605
5
Terlipressin Approved, Investigational Phase 4,Phase 2 14636-12-5 72081
6
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
7
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
8
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
9
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 104987-11-3 445643 439492
10
Lactulose Approved Phase 4,Phase 3,Phase 2 4618-18-2 11333
11
Lenograstim Approved Phase 4,Phase 3,Phase 2 135968-09-1
12
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2 616-91-1 12035
13
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
14
Heparin Approved, Investigational Phase 4,Phase 1 9005-49-6 772 46507594
15
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
16
Daclizumab Approved, Investigational Phase 4,Phase 3 152923-56-3
17
Rifaximin Approved, Investigational Phase 4,Phase 2 80621-81-4 6436173
18
Citalopram Approved Phase 4 59729-33-8 2771
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
21
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351
22
Entecavir Approved, Investigational Phase 4,Phase 2 142217-69-4 153941
23
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
24
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
25
Enalaprilat Approved Phase 4 76420-72-9 6917719
26
Magnesium Sulfate Approved, Vet_approved Phase 4 7487-88-9 24083
27 Antifungal Agents Phase 4,Phase 3,Phase 2
28 Anti-Infective Agents Phase 4,Phase 3,Phase 2
29 Echinocandins Phase 4
30 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
31 Antihypertensive Agents Phase 4,Phase 2
32 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
33 Coagulants Phase 4,Phase 2
34 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Hemostatics Phase 4,Phase 2
36 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
37 Hormones Phase 4,Phase 2,Phase 3,Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
39 Lypressin Phase 4,Phase 2
40 Natriuretic Agents Phase 4,Phase 3,Phase 1,Phase 2
41 Vasoconstrictor Agents Phase 4,Phase 2
42 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
44 Anticoagulants Phase 4,Phase 3
45 Calcium, Dietary Phase 4
46 Chelating Agents Phase 4
47 Excitatory Amino Acid Agonists Phase 4,Phase 2
48 Excitatory Amino Acids Phase 4,Phase 2
49 Neurotransmitter Agents Phase 4,Phase 2
50 N-Methylaspartate Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 276)
id Name Status NCT ID Phase
1 Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure Unknown status NCT01968395 Phase 4
2 Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding Unknown status NCT00966355 Phase 4
3 A Randomized Controlled Trial of Lamivudine in Acute Hepatitis B Completed NCT00380614 Phase 4
4 Randomized Controlled Trial of Tenofovir in Patients of Reactivation of Hepatitis B Presenting as Acute on Chronic Liver Failure Completed NCT01074645 Phase 4
5 Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure" Completed NCT01201720 Phase 4
6 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
7 Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy. Completed NCT01041755 Phase 4
8 Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection Completed NCT00163657 Phase 4
9 Efficacy of Albumin for Acute Encephalopathy in Patients With Cirrhosis Completed NCT00886925 Phase 4
10 Lactulose, L-ornithine L-aspartate, or Rifaximin Versus Placebo for Preventing Hepatic Encephalopathy in Variceal Bleeding Completed NCT02158182 Phase 4
11 L-ornithine L-aspartate in Overt Hepatic Encephalopathy Completed NCT01722578 Phase 4
12 Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit Completed NCT00872027 Phase 4
13 Steroids in Fulminant Hepatic Failure in the Pediatric Age Group Recruiting NCT02375867 Phase 4
14 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Recruiting NCT02757170 Phase 4
15 RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure Recruiting NCT02331745 Phase 4
16 Genetic Determinants of ACEI Prodrug Activation Recruiting NCT03051282 Phase 4
17 A Phase 4, Open Label Multi-Center, Prospective, Randomized Study of Comparing the Efficacy and Safety of Generic vs. Brand Tacrolimus on Kidney Transplant Outcomes in De Novo in Kidney, Heart and Liver Transplant Recipients Not yet recruiting NCT02866682 Phase 4
18 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4
19 Trial of Calcineurin Inhibitor-Sparing Immunosuppression Regimen in Pediatric Liver Transplantation Terminated NCT00656266 Phase 4
20 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4
21 Minocycline Administration During Human Liver Transplantation Withdrawn NCT02712775 Phase 4
22 Lactulose for the Prevention of Hepatic Encephalopathy in Cirrhotic Patients With Upper Gastrointestinal Hemorrhage Unknown status NCT00553423 Phase 3
23 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3
24 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Completed NCT00004467 Phase 3
25 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3
26 The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Completed NCT00224705 Phase 3
27 Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure Completed NCT01471028 Phase 3
28 CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment Completed NCT00604357 Phase 3
29 Efficacy and Safety of Concentration-controlled Everolimus to Eliminate or to Reduce Tacrolimus Compared to Tacrolimus in de Novo Liver Transplant Recipients Completed NCT00622869 Phase 3
30 RESCUE Study - Everolimus in Liver Transplantation Recipients With Renal Insufficiency Completed NCT00267189 Phase 3
31 Extension Study to Evaluate the Long-term Efficacy and Safety of Everolimus in Liver Transplant Recipients Completed NCT01150097 Phase 3
32 Efficacy and Safety of Basiliximab, Cyclosporine/Cyclosporine Microemulsion, and Steroids in Pediatric de Novo Liver Transplant Recipients Avoiding Intraoperative Steroids Completed NCT00149890 Phase 3
33 Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients. Completed NCT01598987 Phase 3
34 A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant Recipients Completed NCT01625377 Phase 3
35 Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients Completed NCT00497796 Phase 3
36 Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN Study) Completed NCT00883948 Phase 3
37 Study to Ascertain if Prolonged Release Tacrolimus (FK506E - MR4) is Safe and Effective When Used in the Long Term and in Combination With Other Immunosuppressive Drugs in Patients Who Have Received a Transplant Completed NCT02118896 Phase 3
38 13C-Methacetin Breath Test for the Prediction of Outcome in ALF Recruiting NCT02786836 Phase 2, Phase 3
39 Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction Recruiting NCT02837939 Phase 2, Phase 3
40 Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD Recruiting NCT02612428 Phase 3
41 Evaluation of the Effect of Gabexate Mesilate in the Hepatocyte Protection After Liver Resection Recruiting NCT02710266 Phase 3
42 Granulocyte Colony Stimulating Factor And Growth Hormone In Cirrhosis Of Liver: An Open Label Study Recruiting NCT02451033 Phase 2, Phase 3
43 Preoperative Glucocorticoid Use in Major Hepatectomy Recruiting NCT01997658 Phase 2, Phase 3
44 REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategy Recruiting NCT02115113 Phase 3
45 Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy Recruiting NCT02464124 Phase 2, Phase 3
46 Study of BEGEDINA® vs "Conventional Treatment" for Treating Steroid-Resistant Acute GvHD Recruiting NCT02411084 Phase 3
47 Artemether-lumefantrine vs Chloroquine for Uncomplicated P. Vivax Malaria in Malaysia Recruiting NCT02348788 Phase 3
48 Diuretic Versus Placebo in Pulmonary Embolism Recruiting NCT02268903 Phase 3
49 The Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury Recruiting NCT00987688 Phase 3
50 Efficacy and Safety of Everolimus in Liver Transplant Recipients of Living Donor Liver Transplants Active, not recruiting NCT01888432 Phase 3

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Liver cells for liver diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes PMIDs: 15239608 12777539 9580649 22789058 22167636
Liver cells PMIDs: 22532025 19295306 19796496 16454359 17060866
Sources

Genetic Tests for Acute Liver Failure

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Genetic tests related to Acute Liver Failure:

id Genetic test Affiliating Genes
1 Acute Hepatic Failure 29
Sources

Anatomical Context for Acute Liver Failure

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MalaCards organs/tissues related to Acute Liver Failure:

39
Liver, Brain, Testes, Neutrophil, T Cells, Kidney, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Potential therapeutic candidate, affected by disease
Sources

Publications for Acute Liver Failure

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Articles related to Acute Liver Failure:

(show top 50) (show all 775)
id Title Authors Year
1
Predicting Fluid Responsiveness in Acute Liver Failure: A Prospective Study. ( 27984249 )
2017
2
Live donor liver transplantation for antitubercular drug-induced acute liver failure. ( 28066854 )
2017
3
Appropriate timing to start and optimal response evaluation of high-dose corticosteroid therapy for patients with acute liver failure. ( 28078470 )
2017
4
Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype. ( 28031453 )
2017
5
Liver transplantation is associated with good clinical outcome in patients with active tuberculosis and acute liver failure due to anti-tubercular treatment. ( 28054732 )
2017
6
American Gastroenterological Association Institute Guidelines for the Diagnosis and Management of Acute Liver Failure. ( 28056348 )
2017
7
Lactate and Lactate: Pyruvate Ratio in the Diagnosis and Outcomes of Pediatric Acute Liver Failure. ( 28088395 )
2017
8
Identifying Brain Dysfunction Among Children With Acute Liver Failure-Can Spectral Electroencephalography Help? ( 28060158 )
2017
9
Budd-chiari syndrome and acute liver failure: A complex condition requiring a rapid response. ( 28006871 )
2017
10
Good outcome of living donor liver transplantation in drug induced acute liver failure: a single centre experience. ( 28054388 )
2017
11
Infectious complications, steroid use and timing for emergency liver transplantation in acute liver failure: Analysis in a Japanese center. ( 27629813 )
2016
12
Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study. ( 27043883 )
2016
13
Hepatitis E virus in acute liver failure: An unusual suspect? ( 27496198 )
2016
14
Sequential analysis of variable markers for predicting outcomes in pediatric patients with acute liver failure. ( 28032939 )
2016
15
Encapsulated platelets modulate Kupffer cell activation and reduce oxidative stress in a model of acute liver failure. ( 27509591 )
2016
16
Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A virus: no evidence of the co-infection as a cause of acute liver failure. ( 27074255 )
2016
17
Development and Pilot of a Checklist for Management of Acute Liver Failure in the Intensive Care Unit. ( 27176033 )
2016
18
Incidence of Primary Mitochondrial Disease in Children Presenting With Acute Liver Failure Under 2 Years of Age. ( 27482763 )
2016
19
The Pathology of Acute Liver Failure. ( 27058243 )
2016
20
Predicting acute liver failure in dengue infection. ( 27031978 )
2016
21
Tamoxifen Attenuates Lipopolysaccharide/Galactosamine-induced Acute Liver Failure by Antagonizing Hepatic Inflammation and Apoptosis. ( 27967264 )
2016
22
A Liver transplantation followed by autologous stem cell transplantation for acute liver failure caused by AL amyloidosis. Case report and review of the literature. ( 27236160 )
2016
23
Combined treatment with MSC transplantation and neutrophil depletion ameliorates D-GalN/LPS-induced acute liver failure in rats. ( 27637473 )
2016
24
Acute Liver Failure. ( 27975112 )
2016
25
Liver Transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis. ( 27216884 )
2016
26
Methanobactin reverses acute liver failure in a rat model of Wilson disease. ( 27322060 )
2016
27
Acute Liver Failure. ( 27959298 )
2016
28
The Impact of Emergency Adult Living-Donor Liver Transplantation on the Survival of Patients with Antituberculosis Therapy-Induced Acute Liver Failure. ( 28006868 )
2016
29
A Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure. ( 27049497 )
2016
30
Acute liver failure impairs function and expression of breast cancer resistant protein (BCRP) at rat blood-brain barrier partly via ammonia-ROS-ERK1/2 activation. ( 27168176 )
2016
31
A Case of Acute Liver Failure during Ritonavir-Boosted Paritaprevir, Ombitasvir and Dasabuvir Therapy in a Patient with HCV Genotype 1b Cirrhosis. ( 27981315 )
2016
32
Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. ( 27482818 )
2016
33
Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy. ( 27921061 )
2016
34
Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism. ( 27483465 )
2016
35
Precise Regulation of miR-210 is Critical for the Cellular Homeostasis Maintenance and Transplantation Efficacy Enhancement of Mesenchymal Stem Cell in Acute Liver Failure Therapy. ( 27983913 )
2016
36
Hypothermia in acute liver failure: what got lost in translation? ( 27184532 )
2016
37
Management for acute liver failure of Wilson disease: Indication for liver transplantation. ( 27061913 )
2016
38
Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine. ( 28076501 )
2016
39
Transplantation of Adipose-Derived Mesenchymal Stem Cells Efficiently Rescues Thioacetamide-Induced Acute Liver Failure in Mice. ( 27569972 )
2016
40
Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis. ( 26971250 )
2016
41
Retrospective evaluation of acute liver failure in dogs (1995-2012): 49 cases. ( 27147282 )
2016
42
Clinical Features and Outcomes of Complementary and Alternative Medicine Induced Acute Liver Failure and Injury. ( 27045922 )
2016
43
C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure. ( 28028363 )
2016
44
Aetiology and Outcome of Acute Liver Failure in Children: Experience at a Tertiary Care Hospital of Bangladesh. ( 27612896 )
2016
45
Acute Liver Failure Caused by Hepatitis A Virus with Dengue Coinfection. ( 27493466 )
2016
46
Frequency and Pathophysiology of Acute Liver Failure in Ornithine Transcarbamylase Deficiency (OTCD). ( 27070778 )
2016
47
Acute Liver Failure - It's Just a Matter of Cell Death. ( 27170397 )
2016
48
N-Acetylcysteine Use in Non-Acetaminophen-Induced Acute Liver Failure. ( 27482990 )
2016
49
Interleukin-10 Contributes to Therapeutic Effect of Mesenchymal Stem Cells for Acute Liver Failure via Signal Transducer and Activator of Transcription 3 Signaling Pathway. ( 27064043 )
2016
50
The role of hepatitis E virus infection in Adult Americans with acute liver failure. ( 27215797 )
2016
Sources

Variations for Acute Liver Failure

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ClinVar genetic disease variations for Acute Liver Failure:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh37 Chromosome 17, 62492543: 62492543
Sources

Expression for Acute Liver Failure

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Search GEO for disease gene expression data for Acute Liver Failure.
Sources

Pathways for Acute Liver Failure

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Pathways related to Acute Liver Failure according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
FOXA2 and FOXA3 transcription factor networks 1
10.27 ALB F2
Sources

GO Terms for Acute Liver Failure

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Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ALB F2 GC GPT HGF
2 blood microparticle GO:0072562 8.8 ALB F2 GC

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of reactive oxygen species metabolic process GO:2000379 9.26 F2 TSPO
2 response to light stimulus GO:0009416 9.16 POLG SLC1A2
3 transport GO:0006810 9.1 ALB GC NBAS SLC17A5 SLC1A2 TSPO
4 anion transport GO:0006820 8.96 SLC17A5 TSPO

Molecular functions related to Acute Liver Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.62 ALB GPT
Sources

Sources for Acute Liver Failure

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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