MCID: ACT134
MIFTS: 48

Acute Liver Failure malady

Genetic diseases, Rare diseases, Liver diseases, Metabolic diseases categories

Aliases & Classifications for Acute Liver Failure

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Sources:
30LifeMap Discovery®, 43Novoseek, 47Orphanet, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Acute Liver Failure, Aliases & Descriptions:

Name: Acute Liver Failure 30 43 47
Acute Hepatic Failure 47
 
Liver Failure, Acute 60
Liver Failure Acute 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Metabolic diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

47
acute liver failure:
Prevalence: 1-5/10000 (Europe)


External Ids:

Orphanet47 90062
MESH via Orphanet34 D017114
ICD10 via Orphanet26 K72.0
UMLS via Orphanet61 C0162557

Summaries for Acute Liver Failure

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Wikipedia:63 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards based summary: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis and hepatitis a. An important gene associated with Acute Liver Failure is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). The compounds hepaplastin and aminopyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related mouse phenotype homeostasis/metabolism.

Related Diseases for Acute Liver Failure

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Diseases in the Liver Disease family:

Infantile Liver Failure Syndrome 1 Infantile Liver Failure Syndrome 2
Liver Failure, Transient Infantile acute liver failure
Liver Failure Acute Infantile Acute Infantile Liver Failure Due to Synthesis Defect of Mtdna-Encoded Proteins

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.6F2, SEPSECS, SLC17A5
2hepatitis a31.4F2
3hepatitis b31.2F2, SLC17A5
4liver disease31.2SEPSECS, F2
5autoimmune hepatitis30.8SLC17A5, SEPSECS, F2
6alcoholic hepatitis30.5F2, SLC17A5
7portal hypertension30.5F2, SLC17A5
8hepatic coma30.4TSPO, F2
9cholestasis30.4SLC17A5, F2
10hepatitis c30.3F2, SLC17A5
11viral hepatitis30.3SLC17A5, SEPSECS, F2
12primary biliary cirrhosis30.3SLC17A5, SEPSECS, F2
13hepatocellular carcinoma29.9SLC17A5, TSPO, F2
14hepatic encephalopathy29.8SLC17A5, GC, TSPO, AQP4, F2
15brain edema10.8
16cerebritis10.6
17wilson disease10.6
18herpes simplex10.4
19choledocholithiasis10.4SLC17A5
20hepatitis e10.4
21liver failure acute infantile10.4
22eye disease10.4TSPO
23leukemia10.4
24endotheliitis10.4
25aplastic anemia10.3
26hemophagocytic lymphohistiocytosis10.3
27hypophosphatemia10.3
28cholangitis10.3SLC17A5, SEPSECS
29adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.3SLC17A5, SEPSECS
30bilirubin metabolic disorder10.2F2, SLC17A5
31alcoholic liver cirrhosis10.2SLC17A5, F2
32choreoacanthocytosis10.2
33focal dermal hypoplasia10.2
34hypersensitivity syndrome, carbamazepine-induced10.2
35familial mediterranean fever, ar10.2
36cystic echinococcosis10.2
37yellow fever10.2
38ebola hemorrhagic fever10.2
39lyell syndrome10.2
40breast cancer10.2
41adult t-cell leukemia10.2
42peripheral t-cell lymphoma10.2
43leptospirosis10.2
44polyarteritis nodosa10.2
45adult-onset still's disease10.2
46amyloidosis10.2
47intracranial hypertension10.2
48lactic acidosis10.2
49pancreatitis10.2
50porphyria10.2

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to acute liver failure

Symptoms for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

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Anatomical Context for Acute Liver Failure

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MalaCards organs/tissues related to Acute Liver Failure:

31
Liver, Brain, Testes, Kidney, T cells, Neutrophil, Bone marrow, Bone, Breast, Endothelial, Heart, Lung, Monocytes, Pancreas, B cells, Skeletal muscle

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

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MGI Mouse Phenotypes related to Acute Liver Failure:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7SLC17A5, GC, AQP4, GK, F2

Publications for Acute Liver Failure

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Articles related to Acute Liver Failure:

(show top 50)    (show all 667)
idTitleAuthorsYear
1
Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. (25885260)
2015
2
Acute liver failure in a patient consuming Herbalife products and Noni juice. (25824932)
2015
3
Paracetamol-associated acute liver failure in Australian and New Zealand children: high rate of medication errors. (25228327)
2014
4
L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. (25258408)
2014
5
Management of acute liver failure in infants and children: consensus statement of the pediatric gastroenterology chapter, Indian academy of pediatrics. (23778727)
2013
6
TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. (23532086)
2013
7
Serum Testosterone Levels and Androgen Receptor CAG Polymorphism Correlate with Hepatitis B Virus (HBV)-Related Acute Liver Failure in Male HBV Carriers. (24391916)
2013
8
Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. (23489904)
2013
9
Letter: treatment of autoimmune acute liver failure--beyond consensus guidelines; author's reply. (24099481)
2013
10
Radiologic and Histologic Heterogeneity in a Case of AutoimmuneA Acute Liver Failure. (23962551)
2013
11
Acute liver failure associated with levetiracetam and lacosamide combination treatment for unspecified epileptic disorder. (24027645)
2013
12
Intraoperative predictors of short-term mortality in living donor liver transplantation due to acute liver failure. (23375307)
2013
13
Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. (24164805)
2013
14
Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. (23166746)
2012
15
Lipopolysaccharide binding protein is down-regulated during acute liver failure. (22278340)
2012
16
Neurological complications of acute liver failure: pathophysiological basis of current management and emerging therapies. (22100567)
2012
17
Neutrophil CD64 expression is elevated in acetaminophen-induced acute liver failure. (23155217)
2012
18
Urgent liver transplantation for nevirapine-induced acute liver failure: report of a case and review of the literature. (22466918)
2012
19
Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats. (22535497)
2012
20
Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia. (22171136)
2011
21
Assessment of emergency liver transplantation criteria in acute liver failure due to Amanita phalloides. (21960294)
2011
22
Effects of intraperitoneal albumin on systemic and cerebral hemodynamics in a swine model of acute liver failure. (21524179)
2011
23
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
24
Early myocardial injury is an integral component of experimental acute liver failure - a study in two porcine models. (22291759)
2011
25
Invasive versus noninvasive intracranial pressure monitoring in children with acute liver failure. (22067827)
2011
26
Metastatic breast cancer presenting as acute liver failure. (21346858)
2011
27
Bridging therapies and liver transplantation in acute liver failure, 10 years of MARS experience from Finland. (21482500)
2011
28
Case report of a successful liver transplantation for acute liver failure due to mitochondrial respiratory chain complex III deficiency. (22172894)
2011
29
Acute liver failure in neonates, infants and children. (22017699)
2011
30
A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review. (21103229)
2010
31
Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)
2010
32
Serum proinflammatory cytokines correlate with diffusion tensor imaging derived metrics and 1H-MR spectroscopy in patients with acute liver failure. (20838864)
2010
33
Drug-induced acute liver failure and gastrointestinal complications. (20502172)
2010
34
Alternative transplant procedures for acute liver failure. (21086942)
2010
35
Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation. (21168638)
2010
36
Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure. (19505222)
2009
37
Sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure. (19954554)
2009
38
A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure. (19590182)
2009
39
De novo mutations in POLG presenting with acute liver failure or encephalopathy. (19252446)
2009
40
Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case. (18609519)
2008
41
Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. (18161828)
2008
42
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
43
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. (17185352)
2007
44
Efficacy and safety of coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration for multiple organ dysfunction syndrome patients with acute liver failure]. (17207366)
2007
45
Caspase 8 small interfering RNA prevents acute liver failure in mice. (12810955)
2003
46
Glycine conjugation of para-aminobenzoic acid (PABA): a pilot study of a novel prognostic test in acute liver failure in children. (12499998)
2003
47
Living related liver transplantation for acute liver failure in children. (10226105)
1999
48
Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)
1997
49
Acute liver failure as the initial manifestation of Wilson disease]. (7565403)
1995
50
Does hypophosphatemia play a role in acute liver failure? (2921001)
1989

Variations for Acute Liver Failure

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Expression for genes affiliated with Acute Liver Failure

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Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

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Compounds for genes affiliated with Acute Liver Failure

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Compounds related to Acute Liver Failure according to GeneCards Suite gene sharing:

(show all 43)
idCompoundScoreTop Affiliating Genes
1hepaplastin4310.1SLC17A5, F2
2aminopyrine4310.1SLC17A5, F2
3antipyrine43 1211.0SLC17A5, F2
4levonorgestrel43 59 28 1213.0F2, SLC17A5
5amiodarone43 49 28 1213.0SLC17A5, F2
6lamivudine43 49 1212.0SLC17A5, F2
7digoxin43 59 49 24 1214.0SLC17A5, F2
8ursodeoxycholic acid43 24 1212.0SLC17A5, F2
9penicillin4310.0TSPO, F2
10halothane43 49 28 1213.0SEPSECS, SLC17A5
11silymarin4310.0SLC17A5, F2
12dipyridamole43 59 28 1212.9TSPO, F2
13thiamine43 2 24 1212.9TSPO, SLC17A5
14isoflurane49 43 1211.9SLC17A5, TSPO
15pge1439.9SLC17A5, F2
16aprotinin43 1210.8F2, SLC17A5
17disulfiram43 49 59 1212.8SLC17A5, TSPO
18phenytoin43 49 28 1212.8TSPO, SLC17A5
19polyethylene glycol439.8SLC17A5, F2
20carbamazepine43 49 1211.8TSPO, SLC17A5
21opiate439.8TSPO, SLC17A5
22benzodiazepine439.7TSPO, GK
23phenobarbital43 28 49 1212.7SLC17A5, TSPO
24lidocaine43 28 1211.6F2, TSPO, SLC17A5
25phosphorus439.5GC, SLC17A5
26valproic acid43 49 24 1212.5SLC17A5, TSPO
27rosiglitazone28 43 49 24 1213.4SLC17A5, GK
28morphine43 49 28 1212.4TSPO, SLC17A5
29chloride439.4AQP4, TSPO, SLC17A5
30bicarbonate439.4GC, AQP4
31acetaminophen43 2 49 24 1213.3SLC17A5, GC, F2
32norepinephrine43 24 1211.2GK, TSPO, SLC17A5
33glycerol43 24 1211.2TSPO, AQP4, GK
34cyclosporin a43 28 5911.2F2, SEPSECS, TSPO, SLC17A5
35fibrinogen439.2F2, GC, SLC17A5
36urea43 24 1211.1AQP4, GC, SLC17A5
37aspartate439.1SLC17A5, GC, F2
38h2o2439.0GK, TSPO, SLC17A5
39fatty acid438.9SLC17A5, GC, GK
40testosterone43 59 24 1211.7SLC17A5, GC, TSPO
41glutamate438.6AQP4, TSPO, GC, SLC17A5
42steroid438.5GC, TSPO, SEPSECS
43creatinine438.1SLC17A5, GC, TSPO, GK, F2

GO Terms for genes affiliated with Acute Liver Failure

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Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00057419.3TSPO, GK

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1anion transportGO:00068209.4SLC17A5, TSPO
2positive regulation of reactive oxygen species metabolic processGO:020003799.3TSPO, F2
3steroid metabolic processGO:00082029.1GC, TSPO

Molecular functions related to Acute Liver Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tRNA bindingGO:00000499.7TRMU, SEPSECS

Products for genes affiliated with Acute Liver Failure

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Sources for Acute Liver Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet