MCID: ACT134
MIFTS: 52

Acute Liver Failure

Categories: Gastrointestinal diseases, Genetic diseases, Rare diseases, Metabolic diseases, Liver diseases

Aliases & Classifications for Acute Liver Failure

MalaCards integrated aliases for Acute Liver Failure:

Name: Acute Liver Failure 37 55 51
Fulminant Hepatic Failure 55 36
Acute Hepatic Failure 55 28
Hepatic Failure Fulminant 51
Liver Failure, Acute 69
Liver Failure Acute 51

Characteristics:

Orphanet epidemiological data:

55
acute liver failure
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 55  
Rare hepatic diseases


External Ids:

Orphanet 55 ORPHA90062
MESH via Orphanet 42 D017114
UMLS via Orphanet 70 C0162557
ICD10 via Orphanet 33 K72.0
KEGG 36 H01712
UMLS 69 C0162557

Summaries for Acute Liver Failure

MalaCards based summary : Acute Liver Failure, also known as fulminant hepatic failure, is related to hepatitis and wilson disease. An important gene associated with Acute Liver Failure is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Acetylcysteine and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and brain.

Wikipedia : 72 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

Related Diseases for Acute Liver Failure

Diseases in the Liver Disease family:

Liver Failure, Infantile, Transient Infantile Liver Failure Syndrome 1
Infantile Liver Failure Syndrome 2 Acute Liver Failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 hepatitis 32.1 F2 GPT SLC17A5
2 wilson disease 30.1 ALB F2 GPT
3 hepatitis a 30.0 ALB F2 GPT
4 hepatitis e 29.9 ALB F2 GPT
5 scrub typhus 29.8 GPT SLC17A5
6 non-a-e hepatitis 29.7 ALB F2
7 hepatitis b 29.7 ALB F2 GPT SLC17A5
8 hepatorenal syndrome 29.6 ALB F2
9 dengue hemorrhagic fever 29.6 ALB F2
10 intracranial hypertension 29.5 F2 F5
11 protein s deficiency 29.3 F2 F5
12 hepatic tuberculosis 29.3 ALB F2 GPT
13 portal hypertension 29.3 ALB F2 GPT
14 factor x deficiency 29.2 F2 F5
15 hemorrhagic fever 29.2 ALB F2 GPT SLC17A5
16 viral hepatitis 29.2 ALB F2 GPT SLC17A5
17 liver disease 29.0 ALB F2 GPT HGF SLC17A5
18 alcoholic hepatitis 28.8 ALB F2 GPT SLC17A5
19 primary biliary cirrhosis 28.8 ALB F2 GPT SLC17A5
20 hepatic coma 28.7 ALB F2 GPT TSPO
21 hepatic encephalopathy 28.3 ALB F2 GC GPT SLC17A5 TSPO
22 infantile liver failure syndrome 1 11.6
23 liver failure, infantile, transient 11.4
24 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 11.3
25 ruijs-aalfs syndrome 11.1
26 infantile liver failure syndrome 2 11.0
27 mitochondrial dna depletion syndrome 4a 10.9
28 hepatoportal sclerosis 10.4 F2 GPT
29 hepatitis d 10.4 F2 GPT
30 paraquat poisoning 10.4 GPT SLC17A5
31 pyridoxine deficiency 10.4 GPT SLC17A5
32 hydrops, lactic acidosis, and sideroblastic anemia 10.3
33 brain edema 10.3
34 separation anxiety disorder 10.2 NBAS TSPO
35 antipyrine metabolism 10.2 ALB F2
36 fournier gangrene 10.2 ALB F2
37 abdominal tuberculosis 10.2 ALB F2
38 splenic disease 10.2 ALB F2
39 esophageal varix 10.2 ALB F2
40 ascending cholangitis 10.2 ALB F2
41 hypersplenism 10.2 ALB F2
42 hepatic vascular disease 10.1 ALB F2
43 blastomycosis 10.1 ALB GC
44 encephalopathy 10.1
45 nonalcoholic steatohepatitis 10.1 F2 GPT SLC17A5
46 legionnaires' disease 10.1 ALB SLC17A5
47 cerebritis 10.1
48 protein-energy malnutrition 10.1 ALB GPT
49 burns 10.1 ALB HGF
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to Acute Liver Failure

Symptoms & Phenotypes for Acute Liver Failure

Drugs & Therapeutics for Acute Liver Failure

Drugs for Acute Liver Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4,Phase 3 616-91-1 12035
2
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
6 Antiviral Agents Phase 4,Phase 3
7 Gastrointestinal Agents Phase 4
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
9 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2
10 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
11 Antidotes Phase 4,Phase 3
12 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2
13 Expectorants Phase 4,Phase 3
14 N-monoacetylcystine Phase 4,Phase 3
15 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
16 Respiratory System Agents Phase 4,Phase 3
17 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2
18 Anti-HIV Agents Phase 4
19 Anti-Retroviral Agents Phase 4
20 Nucleic Acid Synthesis Inhibitors Phase 4
21 Reverse Transcriptase Inhibitors Phase 4
22 Anti-Inflammatory Agents Phase 4
23 Autonomic Agents Phase 4
24 Hormone Antagonists Phase 4
25 Hormones Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
27 Antiemetics Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 glucocorticoids Phase 4
30 Methylprednisolone acetate Phase 4
31 Methylprednisolone Hemisuccinate Phase 4
32 Neuroprotective Agents Phase 4
33 Prednisolone acetate Phase 4
34 Prednisolone hemisuccinate Phase 4
35 Prednisolone phosphate Phase 4
36
Acetaminophen Approved Phase 3,Phase 2 103-90-2 1983
37
Formaldehyde Approved, Vet_approved Phase 2, Phase 3 50-00-0 712
38 Analgesics Phase 3,Phase 2
39 Analgesics, Non-Narcotic Phase 3,Phase 2
40 Antipyretics Phase 3,Phase 2
41 Complement C3a Phase 3,Phase 2
42
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
43
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
44
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
45
Phenylacetic acid Approved Phase 2 103-82-2 999
46
Pentoxifylline Approved, Investigational Phase 1, Phase 2 6493-05-6 4740
47
Dobutamine Approved Phase 2 34368-04-2 36811
48
Norepinephrine Approved Phase 2 51-41-2 439260
49
Ornithine Approved, Nutraceutical Phase 2 70-26-8, 3184-13-2 6262
50 Excitatory Amino Acid Agonists Phase 2

Interventional clinical trials:

(show top 50) (show all 71)

# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Trial of Lamivudine in Acute Hepatitis B Completed NCT00380614 Phase 4 Lamivudine
2 Steroids in Fulminant Hepatic Failure in the Pediatric Age Group Recruiting NCT02375867 Phase 4 prednisolone;methylprednisolone
3 Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography Recruiting NCT02757170 Phase 4
4 Study of N-Acetylcysteine in Acute Liver Failure (ALF) Terminated NCT00896025 Phase 4 N-acetylcysteine
5 Minocycline Administration During Human Liver Transplantation Withdrawn NCT02712775 Phase 4 Minocycline (yes/no);Placebo
6 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
7 Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen Completed NCT00004467 Phase 3 N-acetylcysteine (NAC);Placebo
8 The MARS® Albumin Dialysis System in Patients With Fulminant and Subfulminant Hepatic Failure Completed NCT00224705 Phase 3
9 13C-Methacetin Breath Test for the Prediction of Outcome in ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-methacetin
10 Study to Assess Safety and Efficacy of ELAD in Subjects With Severe Acute Alcoholic Hepatitis (sAAH) and Lille Score Failure Terminated NCT01829347 Phase 3
11 Registry Protocol for Tracking Trial Subjects After VTI-206 Study Completion Withdrawn NCT01452295 Phase 2, Phase 3 ELAD (Extracorporeal Liver Assist System)
12 Cardiox Liver Function Test Pivotal Trial Withdrawn NCT02552901 Phase 3 0.1 mg/kg ICG Dose;0.5 mg/kg ICG dose
13 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
14 Efficacy & Safety of ALF-5755 in Patients With Nonacetaminophen Severe Acute Hepatitis & Early Stage Acute Liver Failure Unknown status NCT01318525 Phase 2 ALF-5755;Saline solution (0.9% NaCl)
15 Phase I/II Study of Recombinant Human Hepatocyte Growth Factor in Fulminant Hepatic Failure Unknown status NCT00225901 Phase 1, Phase 2 Recombinant human hepatocyte growth factor
16 Mesenchymal Stem Cells After Renal or Liver Transplantation Unknown status NCT01429038 Phase 1, Phase 2
17 Emergency Use of OCR-002 in Acute Liver Failure Completed NCT01634230 Phase 2 OCR-002
18 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Completed NCT01548690 Phase 2 Ornithine phenylacetate
19 Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure Completed NCT00030225 Phase 2
20 Safety & Efficacy of the Extracorporeal Liver Assist Device (ELAD) System in Patients With Hepatic Insufficiency Completed NCT00771446 Phase 1, Phase 2
21 Molecular Adsorbent Recirculating System (MARS®) in Hypoxic Hepatitis Recruiting NCT01690845 Phase 2
22 Safety and Efficacy of ELAD to Treat Acute Liver Failure (ALF) Terminated NCT01875874 Phase 2
23 Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF Terminated NCT01937130 Phase 2 IDN-6556
24 Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) Withdrawn NCT00832728 Phase 2
25 Hepatocyte Transplantation in Liver Failure Withdrawn NCT00805610 Phase 1, Phase 2
26 A Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With 2 Formulations (Panadol and SafeTynadol) in Healthy Volunteers Completed NCT03451487 Phase 1 Panadol®;SafeTynadol®
27 Hepatocyte Transplantation for Acute Decompensated Liver Failure Suspended NCT01345565 Phase 1 human hepatocytes
28 A Phase 1 Study of LJPC-501 in Patients With Hepatorenal Syndrome Terminated NCT01906307 Phase 1 LJPC-501
29 Granulocyte Colony Stimulating Factor (G-CSF) in Acute Liver Failure and Alcoholic Hepatitis Unknown status NCT01341951 Granulocyte colony stimulating factor
30 Growth Factors and Hepatic Progenitor Cells in Acute Liver Failure Unknown status NCT01312220
31 Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery Unknown status NCT01435421
32 Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis Unknown status NCT00375635
33 Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects Unknown status NCT01209455 Chlorphenamine and Ranitidine;Paracetamol;Paracetamol
34 Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment Unknown status NCT00772252
35 A Multi-Center Group to Study Acute Liver Failure in Children Completed NCT00986648
36 A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure Completed NCT00950508
37 Risk of Acute Liver Failure Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086293
38 Cerebral Microdialysis in Patients With Fulminant Hepatic Failure Completed NCT00836420
39 The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure Completed NCT00655304
40 Indocyangreen Elimination in Cirrhosis and Acute Liver Failure Completed NCT00245310
41 Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver Failure (ACLF). Completed NCT01946360
42 Unknown Cause of Acute Liver Failure Completed NCT02041637
43 Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure Completed NCT00670124
44 Extended Drug Utilization Study Among Patients Exposed to Ticagrelor, Clopidogrel and Prasugrel Completed NCT01276275 Risk of selected safety events
45 Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF Completed NCT02460510 Mannitol;3% hypertonic saline
46 Neuromonitoring of Hepatic Encephalopathy Completed NCT01878305
47 Hepatic Monitoring for Pazopanib Completed NCT01449825 Pazopanib use;Use of sunitinib, bevacizumab, or sorafenib
48 Adduct Dipstick for Diagnosis of Acetaminophen Toxicity Completed NCT01575847
49 Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure Completed NCT01872767
50 Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc) - Positive Patients Completed NCT00881036

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Liver Failure cell therapies at LifeMap Discovery.

Genetic Tests for Acute Liver Failure

Genetic tests related to Acute Liver Failure:

# Genetic test Affiliating Genes
1 Acute Hepatic Failure 28

Anatomical Context for Acute Liver Failure

MalaCards organs/tissues related to Acute Liver Failure:

38
Liver, Brain, Testes, Endothelial, Neutrophil, Kidney, T Cells
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Potential therapeutic candidate, affected by disease

Publications for Acute Liver Failure

Articles related to Acute Liver Failure:

(show top 50) (show all 820)
# Title Authors Year
1
Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome. ( 29407307 )
2018
2
Drug idiosyncrasy due to pirfenidone presenting as acute liver failure: Case report and mini-review of the literature. ( 29404521 )
2018
3
Identification of key candidate genes and pathways in hepatitis B virus-associated acute liver failure by bioinformatical analysis. ( 29384847 )
2018
4
Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. ( 29253766 )
2018
5
Hepatitis A, cardiomyopathy, aplastic anemia, and acute liver failure: A devastating scenario. ( 29359844 )
2018
6
Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure. ( 29374146 )
2018
7
Acute Liver Failure in an Adolescent Male Induced by Human Herpesvirus 6 (HHV-6): A Case Report With Literature Review. ( 29390152 )
2018
8
Human liver organoids generated with single donor-derived multiple cells rescue mice from acute liver failure. ( 29321049 )
2018
9
SCYL1 variants cause a syndrome with low I^-glutamyl-transferase cholestasis, acute liver failure, and neurodegeneration (CALFAN). ( 29419818 )
2018
10
Early Combination Therapy with Corticosteroid and Nucleoside Analogue Induces Rapid Resolution of Inflammation in Acute Liver Failure Due to Transient Hepatitis B Virus Infection. ( 29321429 )
2018
11
Endoplasmic reticulum stress restrains hepatocyte growth factor expression in hepatic stellate cells and rat acute liver failure model. ( 28844859 )
2017
12
Liver transplantation is associated with good clinical outcome in patients with active tuberculosis and acute liver failure due to anti-tubercular treatment. ( 28054732 )
2017
13
Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease? ( 28914695 )
2017
14
Budd-chiari syndrome and acute liver failure: A complex condition requiring a rapid response. ( 28006871 )
2017
15
Acute Liver Failure due to Trazodone and Diazepam. ( 28848778 )
2017
16
Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype. ( 28031453 )
2017
17
NBAS mutations cause acute liver failure: when acetaminophen is not a culprit. ( 28946922 )
2017
18
American Gastroenterological Association Institute Guidelines for the Diagnosis and Management of Acute Liver Failure. ( 28056348 )
2017
19
Prometheus therapy for the treatment of acute liver failure in patients after cardiac surgery. ( 29354174 )
2017
20
Live donor liver transplantation for antitubercular drug-induced acute liver failure. ( 28066854 )
2017
21
Psychosocial and behavioral factors in acetaminophen-related acute liver failure and liver injury. ( 28867424 )
2017
22
Retrospective Identification of Herpes Simplex 2 Virus-Associated Acute Liver Failure in an Immunocompetent Patient Detected Using Whole Transcriptome Shotgun Sequencing. ( 29441209 )
2017
23
Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab. ( 28948184 )
2017
24
Drug-induced acute liver failure in children and adults: Results of a single-centre study of 128 patients. ( 29222960 )
2017
25
Babesiosis Presenting as Acute Liver Failure. ( 29430231 )
2017
26
Continuous renal replacement therapy is associated with reduced serum ammonia levels and mortality in acute liver failure. ( 28859230 )
2017
27
Delta model for end-stage liver disease and delta clinical prognostic indicator as predictors of mortality in patients with viral acute liver failure. ( 29291180 )
2017
28
Predicting Fluid Responsiveness in Acute Liver Failure: A Prospective Study. ( 27984249 )
2017
29
Recurrent elevated liver transaminases and acute liver failure in two siblings with novel bi-allelic mutations of NBAS. ( 28576691 )
2017
30
A rare cause of acute liver failure- a case report. ( 29262779 )
2017
31
Identifying Brain Dysfunction Among Children With Acute Liver Failure-Can Spectral Electroencephalography Help? ( 28060158 )
2017
32
Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment. ( 28809737 )
2017
33
Dengue hemorrhagic fever complicated with acute liver failure: a case report. ( 29216924 )
2017
34
Is dengue emerging as important cause of acute liver failure in endemic regions? ( 28798927 )
2017
35
Peak hyperammonemia and atypical acute liver failure: the eruption of an urea cycle disorder during hyperemesis gravidarum. ( 28939132 )
2017
36
Management of Cerebral Edema in Acute Liver Failure. ( 29262439 )
2017
37
Parvovirus B19 Infection in a Fatal Case of Acute Liver Failure. ( 28787384 )
2017
38
Acute liver failure caused by pembrolizumab in a patient with pulmonary metastatic liver cancer: A case report. ( 29390572 )
2017
39
Good outcome of living donor liver transplantation in drug induced acute liver failure: a single centre experience. ( 28054388 )
2017
40
Appropriate timing to start and optimal response evaluation of high-dose corticosteroid therapy for patients with acute liver failure. ( 28078470 )
2017
41
Exertional Heat Illness Resulting in Acute Liver Failure and Liver Transplantation. ( 28910461 )
2017
42
Interleukin-10 secreted by mesenchymal stem cells attenuates acute liver failure through inhibiting pyroptosis. ( 28833919 )
2017
43
Intravenous amiodarone-induced acute liver failure in cardiac surgery intensive care unit. ( 29395301 )
2017
44
Mir-24 regulates hepatocyte apoptosis via BIM during acute liver failure. ( 29218090 )
2017
45
Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population. ( 28513770 )
2017
46
Dengue Hemorrhagic Fever: ARare Cause of Acute Liver Failure. ( 28903847 )
2017
47
High ferritin concentration in acute liver failure: the top of the iceberg? ( 28941305 )
2017
48
Acute Liver Failure in a Patient Travelling From Asia: The Other Face of the Coin of Infectious Disease. ( 28912916 )
2017
49
Protective role of hypoxia-inducible factor-1I+-dependent CD39 and CD73 in fulminant acute liver failure. ( 27899277 )
2017
50
Predictors of infection in viral-hepatitis related acute liver failure. ( 28875762 )
2017

Variations for Acute Liver Failure

ClinVar genetic disease variations for Acute Liver Failure:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 POLG2 NM_007215.3(POLG2): c.544C> T (p.Arg182Trp) single nucleotide variant Likely pathogenic rs886037843 GRCh37 Chromosome 17, 62492543: 62492543

Expression for Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for Acute Liver Failure

Pathways related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 ALB F2

GO Terms for Acute Liver Failure

Cellular components related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 ALB F2 F5
2 extracellular space GO:0005615 9.43 ALB F2 F5 GC GPT HGF
3 blood microparticle GO:0072562 9.33 ALB F2 GC
4 platelet alpha granule lumen GO:0031093 8.8 ALB F5 HGF

Biological processes related to Acute Liver Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB F2 F5
2 positive regulation of reactive oxygen species metabolic process GO:2000379 9.16 F2 TSPO
3 anion transport GO:0006820 8.96 SLC17A5 TSPO
4 platelet degranulation GO:0002576 8.8 ALB F5 HGF

Sources for Acute Liver Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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