MCID: ACT134
MIFTS: 53

Acute Liver Failure malady

Rare diseases, Liver diseases, Gastrointestinal diseases categories
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Summaries for Acute Liver Failure

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis and hepatitis b. An important gene associated with Acute Liver Failure is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). The compounds hepaplastin and aminopyrine have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Acute Liver Failure

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Sources:
31LifeMap Discovery™, 45Novoseek, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Liver diseases, Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

49
acute liver failure:
Prevalence: 1-5/10000


Aliases & Descriptions:

acute liver failure 31 45 49
acute hepatic failure 49
liver failure, acute 62
liver failure acute 45


External Ids:

MESH via Orphanet36 D017114
ICD10 via Orphanet26 K72.0
SNOMED-CT via Orphanet59 197270009
UMLS via Orphanet63 C0162557

Related Diseases for Acute Liver Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Liver Disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.4F2, SEPSECS, SLC17A5
2hepatitis b30.9F2, SLC17A5
3hepatitis a30.8F2
4autoimmune hepatitis30.6SLC17A5, SEPSECS, F2
5hepatic encephalopathy30.4SLC17A5, GC, TSPO, AQP4, F2
6hepatic coma30.2TSPO, F2
7alcoholic hepatitis30.2F2, SLC17A5
8portal hypertension30.2F2, SLC17A5
9cholestasis30.1SLC17A5, F2
10hepatitis c30.1F2, SLC17A5
11viral hepatitis30.1SLC17A5, SEPSECS, F2
12primary biliary cirrhosis30.1SLC17A5, SEPSECS, F2
13hepatocellular carcinoma30.0SLC17A5, TSPO, F2
14brain edema10.8
15cerebritis10.6
16wilson disease10.5
17liver disease10.5
18herpes simplex10.4
19hepatitis e10.4
20liver failure acute infantile10.4
21hypertension10.3
22leukemia10.3
23endotheliitis10.3
24hemophagocytic lymphohistiocytosis10.3
25aplastic anemia10.3
26leptospirosis10.2
27polyarteritis nodosa10.2
28hypophosphatemia10.2
29adult t-cell leukemia10.2
30amyloidosis10.2
31breast cancer10.2
32intracranial hypertension10.2
33pancreatitis10.2
34porphyria10.2
35t-cell leukemia10.2
36macrophage activation syndrome10.2
37neonatal herpes10.2
38patent ductus venosus10.2
39peripheral t-cell lymphoma10.2
40sepsis10.2
41choledocholithiasis10.1SLC17A5
42eye disease10.1TSPO
43cholangitis10.1SLC17A5, SEPSECS
44congenital stationary night blindness, type 1f10.1SLC17A5, SEPSECS
45bilirubin metabolic disorder10.1F2, SLC17A5
46graft versus host disease10.1
47cardiac tamponade10.1
48peliosis hepatis10.1
49diabetes insipidus10.1
50focal dermal hypoplasia10.1

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to acute liver failure

Symptoms for Acute Liver Failure

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Drugs & Therapeutics for Acute Liver Failure

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

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Anatomical Context for Acute Liver Failure

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Acute Liver Failure:

33
Liver, Brain, T cells, Testes, Kidney, Endothelial, Bone marrow, Bone, Breast, Monocytes, Heart, Lung, B cells, Pancreas, Skeletal muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Acute Liver Failure:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7SLC17A5, GC, AQP4, GK, F2

Publications for Acute Liver Failure

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Sources:
52PubMed
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Articles related to Acute Liver Failure:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
Management of acute liver failure in infants and children: consensus statement of the pediatric gastroenterology chapter, Indian academy of pediatrics. (23778727)
2013
2
TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure. (23532086)
2013
3
Serum Testosterone Levels and Androgen Receptor CAG Polymorphism Correlate with Hepatitis B Virus (HBV)-Related Acute Liver Failure in Male HBV Carriers. (24391916)
2013
4
Significant advances towards a reproducible, clinically relevant large animal model of acetaminophen-induced acute liver failure. (23489904)
2013
5
Letter: treatment of autoimmune acute liver failure--beyond consensus guidelines; author's reply. (24099481)
2013
6
Radiologic and Histologic Heterogeneity in a Case of AutoimmuneA Acute Liver Failure. (23962551)
2013
7
Acute liver failure associated with levetiracetam and lacosamide combination treatment for unspecified epileptic disorder. (24027645)
2013
8
Intraoperative predictors of short-term mortality in living donor liver transplantation due to acute liver failure. (23375307)
2013
9
Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. (24164805)
2013
10
Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications. (23166746)
2012
11
Lipopolysaccharide binding protein is down-regulated during acute liver failure. (22278340)
2012
12
Neurological complications of acute liver failure: pathophysiological basis of current management and emerging therapies. (22100567)
2012
13
Neutrophil CD64 expression is elevated in acetaminophen-induced acute liver failure. (23155217)
2012
14
Urgent liver transplantation for nevirapine-induced acute liver failure: report of a case and review of the literature. (22466918)
2012
15
Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats. (22535497)
2012
16
GABAergic neurosteroids: the "endogenous benzodiazepines" of acute liver failure. (22041164)
2012
17
Acute liver failure. (22447259)
2012
18
Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia. (22171136)
2011
19
Assessment of emergency liver transplantation criteria in acute liver failure due to Amanita phalloides. (21960294)
2011
20
Effects of intraperitoneal albumin on systemic and cerebral hemodynamics in a swine model of acute liver failure. (21524179)
2011
21
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
22
Early myocardial injury is an integral component of experimental acute liver failure - a study in two porcine models. (22291759)
2011
23
Invasive versus noninvasive intracranial pressure monitoring in children with acute liver failure. (22067827)
2011
24
Metastatic breast cancer presenting as acute liver failure. (21346858)
2011
25
Bridging therapies and liver transplantation in acute liver failure, 10 years of MARS experience from Finland. (21482500)
2011
26
Case report of a successful liver transplantation for acute liver failure due to mitochondrial respiratory chain complex III deficiency. (22172894)
2011
27
Acute liver failure in neonates, infants and children. (22017699)
2011
28
Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. (21499580)
2011
29
A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review. (21103229)
2010
30
Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)
2010
31
Serum proinflammatory cytokines correlate with diffusion tensor imaging derived metrics and 1H-MR spectroscopy in patients with acute liver failure. (20838864)
2010
32
Drug-induced acute liver failure and gastrointestinal complications. (20502172)
2010
33
Alternative transplant procedures for acute liver failure. (21086942)
2010
34
Japanese-style intensive medical care improves prognosis for acute liver failure and the perioperative management of liver transplantation. (21168638)
2010
35
Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure. (19505222)
2009
36
Sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure. (19954554)
2009
37
A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure. (19590182)
2009
38
De novo mutations in POLG presenting with acute liver failure or encephalopathy. (19252446)
2009
39
Acetaminophen-induced acute liver failure treated with single-pass albumin dialysis: report of a case. (18609519)
2008
40
Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. (18161828)
2008
41
Effects of granulocyte colony-stimulating factor on hepatocyte apoptosis in acute liver failure: experiment with rats]. (18756972)
2008
42
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
43
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. (17185352)
2007
44
Efficacy and safety of coupled plasma filtration adsorption combined with continuous veno-venous hemofiltration for multiple organ dysfunction syndrome patients with acute liver failure]. (17207366)
2007
45
Caspase 8 small interfering RNA prevents acute liver failure in mice. (12810955)
2003
46
Glycine conjugation of para-aminobenzoic acid (PABA): a pilot study of a novel prognostic test in acute liver failure in children. (12499998)
2003
47
Living related liver transplantation for acute liver failure in children. (10226105)
1999
48
Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)
1997
49
Acute liver failure as the initial manifestation of Wilson disease]. (7565403)
1995
50
Does hypophosphatemia play a role in acute liver failure? (2921001)
1989

Variations for Acute Liver Failure

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Expression for genes affiliated with Acute Liver Failure

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

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Compounds for genes affiliated with Acute Liver Failure

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1hepaplastin4510.1SLC17A5, F2
2aminopyrine4510.1SLC17A5, F2
3antipyrine45 1111.0SLC17A5, F2
4levonorgestrel45 61 29 1113.0F2, SLC17A5
5amiodarone45 51 29 1113.0SLC17A5, F2
6lamivudine45 51 1112.0SLC17A5, F2
7digoxin45 61 51 24 1114.0SLC17A5, F2
8ursodeoxycholic acid45 24 1112.0SLC17A5, F2
9penicillin4510.0TSPO, F2
10halothane45 51 29 1113.0SEPSECS, SLC17A5
11silymarin4510.0SLC17A5, F2
12dipyridamole45 61 29 1112.9TSPO, F2
13thiamine45 3 24 1112.9TSPO, SLC17A5
14isoflurane51 45 1111.9SLC17A5, TSPO
15pge1459.9SLC17A5, F2
16aprotinin45 1110.8F2, SLC17A5
17disulfiram45 51 61 1112.8SLC17A5, TSPO
18phenytoin45 51 29 1112.8TSPO, SLC17A5
19polyethylene glycol459.8SLC17A5, F2
20carbamazepine45 51 1111.8TSPO, SLC17A5
21opiate459.8TSPO, SLC17A5
22benzodiazepine459.7TSPO, GK
23phenobarbital45 29 51 1112.7SLC17A5, TSPO
24lidocaine45 29 1111.6F2, TSPO, SLC17A5
25phosphorus459.5GC, SLC17A5
26valproic acid45 51 24 1112.5SLC17A5, TSPO
27rosiglitazone29 45 51 24 1113.4SLC17A5, GK
28morphine45 51 29 1112.4TSPO, SLC17A5
29chloride459.4AQP4, TSPO, SLC17A5
30bicarbonate459.4GC, AQP4
31acetaminophen45 3 51 24 1113.3SLC17A5, GC, F2
32norepinephrine45 24 1111.2GK, TSPO, SLC17A5
33glycerol45 24 1111.2TSPO, AQP4, GK
34cyclosporin a45 29 6111.2F2, SEPSECS, TSPO, SLC17A5
35fibrinogen459.2F2, GC, SLC17A5
36urea45 24 1111.1AQP4, GC, SLC17A5
37aspartate459.1SLC17A5, GC, F2
38h2o2459.0GK, TSPO, SLC17A5
39fatty acid458.9SLC17A5, GC, GK
40testosterone45 61 24 1111.7SLC17A5, GC, TSPO
41glutamate458.6AQP4, TSPO, GC, SLC17A5
42steroid458.5GC, TSPO, SEPSECS
43creatinine458.1SLC17A5, GC, TSPO, GK, F2

GO Terms for genes affiliated with Acute Liver Failure

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Sources:
16Gene Ontology
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Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.3TSPO, GK

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anion transportGO:0068209.4SLC17A5, TSPO
2positive regulation of reactive oxygen species metabolic processGO:20003799.3TSPO, F2
3steroid metabolic processGO:0082029.1GC, TSPO

Molecular functions related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tRNA bindingGO:0000499.7TRMU, SEPSECS

Products for genes affiliated with Acute Liver Failure

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Liver Failure

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet