MCID: ACT134
MIFTS: 57

Acute Liver Failure malady

Liver diseases category

Summaries for Acute Liver Failure

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Acute liver failure is the appearance of severe complications rapidly after the first signs of liver... more...

MalaCards: Acute Liver Failure, also known as acute hepatic failure, is related to hepatitis and hepatitis a. An important gene associated with Acute Liver Failure is F2 (coagulation factor II (thrombin)), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Common Pathway. The compounds d-galactosamine and 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and t cells, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Acute Liver Failure

About this section
Sources:
30LifeMap Discovery™, 44Novoseek, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
acute liver failure:
Prevalence: 1-5/10000


Aliases & Descriptions:

acute liver failure 30 44 48
acute hepatic failure 48
liver failure, acute 60
liver failure acute 44


External Ids:

MESH via Orphanet35 D017114
ICD10 via Orphanet26 K72.0
SNOMED-CT via Orphanet57 197270009
UMLS via Orphanet61 C0162557

Related Diseases for Acute Liver Failure

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Liver Disease family:

acute liver failure

Diseases related to Acute Liver Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3GPT, SLC17A5
2hepatitis a31.0F2
3wilson disease30.7OTC, SLC17A5, GPT
4hepatitis b30.7SLC17A5, F2, GPT, FGL2, AFP
5liver cirrhosis30.6HGF, AFP, GPT, F2, SLC17A5, TSPO
6herpes simplex30.6GC
7hepatitis e30.6GPT
8hepatic encephalopathy30.5GC, GPT, F2, SLC17A5, TSPO
9hypertension30.5F2
10autoimmune hepatitis30.5SEPSECS
11leukemia30.4CCL20, EIF2AK3, FST, OTC
12pancreatitis30.2SLC17A5
13acute pancreatitis30.2SLC17A5, GPT
14porphyria30.2ALAS1
15viral hepatitis30.2AFP, FGL2, GPT, F2, SLC17A5, SEPSECS
16endometriosis30.0FST, HGF, GC
17ischemia30.0HGF, EIF2AK3, FST, SLC17A5
18cholangiocarcinoma30.0HGF, AFP
19arthritis30.0CCL20, CD163
20tuberculosis30.0GC
21acute myocardial infarction30.0F7
22hepatic coma30.0F2, TSPO
23myocardial infarction30.0F7, CD163
24cholestasis30.0GPT, F2, SLC17A5
25portal hypertension30.0GPT, F2, SLC17A5
26alcoholic liver cirrhosis30.0SLC17A5, F2, GPT
27factor x deficiency30.0F7, F2
28alcoholic hepatitis30.0F2, HGF
29primary biliary cirrhosis30.0GPT, F2, SLC17A5, SEPSECS
30hepatitis c30.0AFP, GPT, F2, SLC17A5
31brain disease30.0GC, GPT, F2, SLC17A5, OTC, TSPO
32myopathy30.0SLC17A5, GPT, GK
33hepatocellular carcinoma30.0HGF, CCL20, AFP, F7, EIF2AK3, GPT
34brain edema10.7
35liver disease10.7
36cerebritis10.5
37acute kidney failure10.4
38liver failure acute infantile10.4
39liver lymphoma10.3
40acute leukemia10.3
41hemophagocytic lymphohistiocytosis10.3
42acute t cell leukemia10.3
43aplastic anemia10.3
44respiratory failure10.3
45t-cell leukemia10.3
46hypophosphatemia10.2
47adult t-cell leukemia10.2
48leptospirosis10.2
49polyarteritis nodosa10.2
50acute porphyria10.2

Graphical network of the top 20 diseases related to Acute Liver Failure:



Diseases related to acute liver failure

Clinical Features for Acute Liver Failure

About this section

Drugs & Therapeutics for Acute Liver Failure

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Liver Failure

Drug clinical trials:

Search ClinicalTrials for Acute Liver Failure

Search NIH Clinical Center for Acute Liver Failure

Search CenterWatch for Acute Liver Failure

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Liver Failure cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Liver Failure:
Hepatocyte transplantation for treatment of liver disorders
Hepatocyte transplantation for treatment of liver failure and inherited metabolic diseases
Embryonic/Adult Cultured Cells Related to Acute Liver Failure:
Hepatocytes, PMIDs: 15239608, 12777539, 9580649, 22789058, 22167636
Hepatocytes

Genetic Tests for Acute Liver Failure

About this section

Anatomical Context for Acute Liver Failure

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Acute Liver Failure:

32
Liver, Brain, T cells, Kidney, Testes, Bone, Bone marrow, Breast, Endothelial, Heart, Lung, Monocytes, Nk cells, B cells, Pancreas, Skeletal muscle

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Liver Failure:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Potential therapeutic candidate, affected by disease

Animal Models for Acute Liver Failure or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Acute Liver Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.7GK, AFP, F7, FGL2, EIF2AK3, LECT2
2MP:00107689.4ALAS1, HGF, GK, AFP, F7, FGL2

Publications for Acute Liver Failure

About this section
Sources:
50PubMed
See all sources

Articles related to Acute Liver Failure:

(show top 50)    (show all 716)
idTitleAuthorsYear
1
Exhaled breath analysis with electronic nose technology for detection of acute liver failure in rats. (24135544)
2014
2
Radiologic and Histologic Heterogeneity in a Case of AutoimmuneA Acute Liver Failure. (23962551)
2013
3
Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. (24164805)
2013
4
Acute liver failure associated with propylthiouracil in a pregnant 26-year-old woman. (23798915)
2013
5
Artificial neural network is highly predictive of outcome in paediatric acute liver failure. (23802584)
2013
6
Mycobacterium kansasii septicemia in an AIDS patient complicated by acute respiratory distress syndrome and acute liver failure. (23970643)
2013
7
Acute liver failure resulting from discontinuation of nucleoside analogues in chronic hepatitis B patients: a report of two cases. (22830672)
2013
8
Hypoxic hepatitis and acute liver failure in a patient with newly onset atrial fibrillation and diltiazem infusion. (24042208)
2013
9
Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure. (23389887)
2013
10
Portal Vein Arterialization as a Bridge Procedure Against Acute Liver Failure After Extended Hepatectomy for Hilar Cholangiocarcinoma. (24172166)
2013
11
Selective head cooling for the treatment of neurologic complications of acute liver failure in a newborn with disseminated herpes infection. (24255865)
2013
12
Pathophysiology of cerebral oedema in acute liver failure. (24409052)
2013
13
Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser. (23763943)
2013
14
Factors associated with outcome in acute liver failure in an intensive care unit. (23054946)
2013
15
Acute kidney injury following acute liver failure: potential role of systemic cadmium mobilization? (22237746)
2012
16
Acute liver failure, multiorgan failure, cerebral oedema, and activation of proangiogenic and antiangiogenic factors in a case of Marburg haemorrhagic fever. (22394985)
2012
17
Acute liver failure: we measure the intracranial pressure and now what?. (22222656)
2012
18
Acute liver failure in young children with systemic-onset juvenile idiopathic arthritis without macrophage activation syndrome: report of two cases. (22050445)
2012
19
Assessment of emergency liver transplantation criteria in acute liver failure due to Amanita phalloides. (21960294)
2011
20
Is there a role for extracorporeal liver support as a bridge to liver transplantation in acute liver failure? (21989274)
2011
21
Accuracy of MELD scores in predicting mortality in decompensated cirrhosis from variceal bleeding, hepatorenal syndrome, alcoholic hepatitis, or acute liver failure as well as mortality after non-transplant surgery or TIPS. (20844956)
2011
22
Occludin is regulated by epidermal growth factor receptor activation in brain endothelial cells and brains of mice with acute liver failure. (21480332)
2011
23
Celiac artery trunk thrombosis presenting as acute liver failure. (21575541)
2011
24
Hepatocyte growth factor promotes liver regeneration induced by transfusion of bone marrow mononuclear cells in a murine acute liver failure model. (21076985)
2011
25
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. (20977905)
2011
26
Acute liver failure in a pediatric patient with disseminated tuberculosis. (21695402)
2011
27
Granulocyte colony-stimulating factor treatment ameliorates liver injury and improves survival in rats with D-galactosamine-induced acute liver failure. (21550386)
2011
28
Acute liver failure. (20691389)
2010
29
Pediatric living-donor liver transplantation for acute liver failure: analysis of 57 cases. (20158695)
2010
30
Lactate is important in determining prognosis in acute liver failure. (20471710)
2010
31
Liver transplantation for acute liver failure: a Spanish perspective. (20304207)
2010
32
Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure. (20353598)
2010
33
Prognostic models for acute liver failure. (20382580)
2010
34
Is lactate concentration of major value in determining the prognosis in patients with acute liver failure? Hardly. (20447712)
2010
35
Role of monocytes and macrophages in experimental and human acute liver failure. (20397256)
2010
36
A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure. (19590182)
2009
37
Prediction of the prognosis of patients with acute-on-chronic hepatitis B liver failure using the model for end-stage liver disease scoring system and a novel logistic regression model. (19413694)
2009
38
Impaired TLR3/IFN-beta signaling in monocyte-derived dendritic cells from patients with acute-on-chronic hepatitis B liver failure: relevance to the severity of liver damage. (19833099)
2009
39
Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. (18161828)
2008
40
Emergency right lobe adult-to-adult live-donor liver transplantation for the treatment of acute liver failure following severe hepatitis]. (19094619)
2008
41
Rapid evolution of congenital hepatic fibrosis after liver transplantation for acute liver failure: the potential role of extrahepatic factors. (18433070)
2008
42
The coagulopathy of acute liver failure and implications for intracranial pressure monitoring. (18379899)
2008
43
Brain edema in acute liver failure: can it be prevented? Can it be treated? (17316881)
2007
44
Aetiology, clinical profile and prognostic indicators for children with acute liver failure admitted in a teaching hospital in Kolkata. (18384007)
2007
45
Acute liver failure in pregnancy associated with maternal MCAD deficiency. (17186412)
2007
46
Soluble CD163 from activated macrophages predicts mortality in acute liver failure. (17629586)
2007
47
Molecular characterization of hepatitis E virus in three acute liver failure cases in children in Argentina]. (17407988)
2006
48
The decrease in cytokine concentration during albumin dialysis correlates with the prognosis of patients with acute on chronic liver failure. (16182740)
2005
49
Acute liver failure due to enalapril. (11141678)
2000
50
Acute liver failure due to diffuse intrasinusoidal metastases of urothelial carcinoma. (8903067)
1996

Genetic Variations for Acute Liver Failure

About this section

Expression for genes affiliated with Acute Liver Failure

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Liver Failure

Search GEO for disease gene expression data for Acute Liver Failure.

Pathways for genes affiliated with Acute Liver Failure

About this section
Sources:
53Reactome, 49PharmGKB, 51QIAGEN, 37NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Acute Liver Failure

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Acute Liver Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1d-galactosamine4410.7HGF, GPT, SLC17A5
25-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)1110.7F2, F7
3aminopyrine4410.7SLC17A5, GPT, F2
4hepaplastin4410.7GPT, SLC17A5, F2, HGF
5lamivudine44 1111.7F2, SLC17A5
6lidocaine44 28 1112.7HGF, TSPO, F2, SLC17A5
7ursodeoxycholic acid44 11 2412.7HGF, F2, GPT, SLC17A5
8levonorgestrel44 59 28 1113.7SLC17A5, F2, F7
9isoflurane44 1111.6GPT, TSPO, SLC17A5
10vitamin a44 11 2412.6GTF3A, HGF, GC, FST
11glutamate4410.6GPT, LECT2, OTC, TSPO
12pge14410.6SLC17A5, F2, GPT, HGF
13fatty acid4410.6HGF, OTC, SLC17A5, GK
14vitamin-e4410.6F7, EIF2AK3, GPT, SLC17A5, HGF
15phenobarbital44 28 1112.6TSPO, GPT, HGF, ALAS1, SLC17A5
165-hydroxytryptophol4410.6GPT, SLC17A5
17ccl444 2811.6CCL20, AFP, GPT, SLC17A5, HGF
18valproic acid44 49 11 2413.6GPT, TSPO, OTC, SLC17A5
19acetaminophen44 2 49 11 2414.6F2, AFP, HGF, GC, SLC17A5, GPT
20urea44 11 2412.6GC, OTC, SLC17A5, GPT, AFP
21glucose4410.6FST, GK, SLC17A5, OTC, GTF3A
22pyruvate4410.6HGF, SLC17A5, GPT, GK, OTC
23methotrexate44 49 1112.6GPT, HGF, AFP, F2, SLC17A5
24serine4410.6AFP, F7, FGL2, GTF3A, SEPSECS
25simvastatin44 49 59 28 11 2415.5AFP, GPT, F2, SLC17A5
26cyclosporin a44 28 5912.5HGF, TSPO, SEPSECS, SLC17A5, F2, GPT
27thyroxine44 2411.5AFP, GPT, SLC17A5, GC
28disulfiram44 59 1112.5GPT, TSPO, SLC17A5
29hyaluronic acid44 2411.5HGF, GPT, F2, SLC17A5
30phosphorus4410.5GC, GPT, SLC17A5
31alpha-hydroxybutyrate4410.5SLC17A5, GPT
32silymarin4410.5GPT, F2, SLC17A5
33glycogen44 2411.5OTC, SLC17A5, GPT, AFP, HGF
34lactate4410.5GPT, AFP, HGF, OTC, F2, FST
35iron44 2411.4AFP, CD163, GPT, SLC17A5, ALAS1, CCL20
36testosterone44 59 11 2413.4TSPO, SLC17A5, AFP, HGF, GC, FST
37fibrinogen4410.4FGL2, GC, F7, GTF3A, SLC17A5, F2
38glutamine4410.4HGF, AFP, EIF2AK3, GPT, LECT2, SLC17A5
39valproate4410.4GPT, SLC17A5, OTC
40aspartate4410.4HGF, SLC17A5, OTC, F2, GPT, EIF2AK3
41steroid4410.4FST, GTF3A, GC, TSPO, SEPSECS, AFP
42atp44 2811.4HGF, EIF2AK3, GK, FST, SLC17A5, OTC
43pyridoxal 5-phosphate4410.4SLC17A5, GPT, ALAS1
44lipid4410.3AFP, CD163, GC, F7, SLC17A5, OTC
45alanine4410.3EIF2AK3, HGF, CCL20, AFP, ALAS1, GPT
46creatinine4410.3FST, GC, HGF, AFP, GK, F7
47glycerol44 11 2412.2TSPO, OTC, GK, EIF2AK3
48Pyridoxal Phosphate1110.2SEPSECS, GPT, ALAS1
49nitric oxide44 11 2412.1FST, CCL20, EIF2AK3, SLC17A5, OTC, F7
50calcium44 49 11 2412.6CD163, F7, EIF2AK3, RGN, AFP, CCL20

GO Terms for genes affiliated with Acute Liver Failure

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0HGF, CCL20, CD163, F7, F2, FST
2extracellular spaceGO:0056159.7F2, GC, HGF, CCL20, AFP, F7

Biological processes related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:03019410.4F2, F7
2anion transportGO:00682010.3TSPO, SLC17A5
3peptidyl-glutamic acid carboxylationGO:01718710.1F2, F7

Molecular functions related to Acute Liver Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.3ALAS1, SEPSECS, GPT

Products for genes affiliated with Acute Liver Failure

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Liver Failure

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet