Acute Lymphoblastic Leukemia malady

Wikipedia: Acute lymphoblastic leukemia (ALL) is a form of leukemia, or cancer of the white blood cells...⁴⁴ more...

MalaCards: Acute Lymphoblastic Leukemia, also known as acute lymphocytic leukemia, is related to lymphoblastic leukemia and leukemia. An important gene associated with Acute Lymphoblastic Leukemia is TSPAN7 (tetraspanin 7), and among its related pathways are Akt Signaling and Antioxidant Action of Vitamin-C. The drugs isotretinoin and methotrexate and the compounds estrogen and progesterone have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related mouse phenotypes are cellular and mortality/aging.

acute lymphoblastic leukemia 30 acute lymphocytic leukemia 30 43 leukemia, acute lymphoblastic 33

lymphoblastic leukemia acute 32 leukemia 43 all 30

Disease types for acute lymphoblastic leukemia family:

leukemia, acute lymphoblastic 2

Diseases related to acute lymphoblastic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1476)

id	Related Disease	Score	Top Affiliating Genes
1	lymphoblastic leukemia	132.5	ZNF384, ZNF521, PIK3CA, PICALM, PIK3CG, LRP5
2	leukemia	131.5	ZNF384, ZNF521, PIK3CA, PICALM, PIK3CG, LRP5
3	carcinoma	93.7	ZNF384, PIK3CA, PIK3CG, LRP5, KLF10, KLF5
4	prostatitis	73.8	PIK3CA, PIK3CG, LRP5, KLF10, KLF5, RFC1
5	myeloid leukemia	71.4	PIK3CA, PICALM, PIK3CG, LRP5, KLF5, NCAM1
6	neuronitis	68.7	ZNF384, PIK3CA, PICALM, PIK3CG, KLF10, NCAM1
7	pancreatitis	66.1	PIK3CA, PIK3CG, LRP5, KLF10, KLF5, NCAM1
8	lymphocytic leukemia	64.8	PIK3CA, PIK3CG, NCAM1, RELA, KIT, KITLG
9	acute leukemia	63.8	ZNF384, PIK3CA, PICALM, NCAM1, KIT, KITLG
10	acute myeloid leukemia	63.6	PIK3CA, PICALM, PIK3CG, LRP5, KLF5, NCAM1
11	melanoma	62.0	PIK3CA, PIK3CG, KLF5, NCAM1, NCOA3, RELA
12	adenocarcinoma	61.0	PIK3CA, PIK3CG, KLF10, NCAM1, NCOA3, RELA
13	thyroiditis	59.9	PIK3CA, PICALM, PIK3CG, COG2, KLF10, RFC1
14	myeloma	59.5	PIK3CA, PIK3CG, LRP5, NCAM1, RELA, KIT
15	hepatocellular carcinoma	58.6	ZNF384, PIK3CA, PIK3CG, NCAM1, NCOA3, RELA
16	arthritis	57.4	PIK3CG, LRP5, KLF5, RFC1, RELA, KIT
17	gastric cancer	57.2	PIK3CA, PIK3CG, KLF5, RFC1, NCOA3, RELA
18	rheumatoid arthritis	54.7	PIK3CG, LRP5, KLF5, RFC1, RELA, KIT
19	sarcoma	54.4	ZNF384, PIK3CA, PIK3CG, NCAM1, NCOA3, RELA
20	neuroblastoma	54.3	PIK3CA, PIK3CG, NCAM1, RELA, KIT, KITLG
21	cervicitis	52.9	ZNF384, PIK3CA, PIK3CG, RFC1, RELA, KIT
22	multiple myeloma	52.9	PIK3CA, PIK3CG, NCAM1, RELA, KIT, KITLG
23	colon cancer	50.4	PIK3CA, PIK3CG, KLF5, RFC1, NCAM1, RELA
24	esophagitis	50.1	PIK3CA, PIK3CG, KLF5, NCAM1, NCOA3, RELA
25	non-hodgkin lymphoma	50.0	KITLG, NBN, SELL, NAT1, NAT2, VDR
26	anemia	49.4	NCAM1, RELA, KIT, KITLG, VWF, PCNA
27	leukemia/lymphoma	48.7	PIK3CA, PIK3CG, RFC1, KITLG, RB1, NBN
28	alzheimer's disease	47.8	PIK3CA, PICALM, PIK3CG, COG2, RFC1, NCAM1
29	hypoxia	47.3	PIK3CA, PIK3CG, LRP5, KLF5, RELA, KIT
30	lupus erythematosus	47.0	PIK3CG, COG2, KIR3DL1, VWF, SFTPD, PCNA
31	lung carcinoma	46.8	PIK3CA, PIK3CG, NCAM1, SFTPD, PCNA, RB1
32	breast carcinoma	46.5	PIK3CA, PIK3CG, NCOA3, KIT, KITLG, VWF
33	cholesterol	46.4	PIK3CA, PIK3CG, LRP5, COG2, KLF5, NCOA3
34	cerebritis	46.0	PIK3CG, COG2, NCAM1, RELA, CNTNAP2, KITLG
35	adult t-cell leukemia	45.8	NCAM1, MYC, MYB, PAX5, BCL2, BCL2L1
36	squamous cell carcinoma	45.8	PIK3CA, NCOA3, RELA, PCNA, RB1, NBN
37	asthma	45.4	PIK3CA, PIK3CG, KIT, KITLG, SFRP5, SFTPD
38	chronic lymphocytic leukemia	44.7	SELL, BRCA2, LPL, MYB, BIRC2, BIRC5
39	chronic myeloid leukemia	44.6	PIK3CG, KIT, KITLG, KIR3DL1, SELP, MYC
40	osteosarcoma	44.6	PIK3CA, PIK3CG, LRP5, KLF10, RFC1, PDE1A
41	retinoblastoma	44.1	PIK3CA, PIK3CG, RFC1, NCAM1, KIT, KITLG
42	obesity	43.9	PIK3CA, PIK3CG, LRP5, COG2, NCOA3, RELA
43	ovarian carcinoma	43.9	PIK3CA, PIK3CG, NCOA3, RELA, KIT, PCNA
44	burkitt's lymphoma	43.9	MYC, MYB, MYBL1, BMI1, BMP6, RAG1
45	adenoma	43.9	PIK3CA, NCAM1, NCOA3, KIT, KITLG, SFRP1
46	retinitis	43.7	PIK3CA, PIK3CG, LRP5, KIT, KITLG, VWF
47	pneumonia	43.3	COG2, RELA, SFTPD, BTK, SELL, SERPINC1
48	hodgkin's lymphoma	43.0	PIK3CG, SELP, SERPINB9, BSG, BRCA2, BMI1
49	hematopoiesis	42.7	PIK3CG, NCOA3, KIT, KITLG, PCNA, RB1
50	acute lymphocytic leukemia	42.4	RB1, SERPINC1, VEGFA, VEGFC, LPL, MYC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cytarabine, cytarabine liposome, doxorubicin hydrochloride, irinotecan, irinotecan hydrochloride, isotretinoin, methotrexate, methotrexate sodium, pipobroman, vincristine, vincristine sulfate

MalaCards organs/tissues related to acute lymphoblastic leukemia:

²²

MGI Mouse Phenotypes related to acute lymphoblastic leukemia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	34.7	PIK3CA, PICALM, PIK3CG, LRP5, KLF10, KLF5
2	mortality/aging	MP:0010768	34.7	PIK3CA, PICALM, LRP5, KLF5, NCAM1, RELA
3	growth/size phenotype	MP:0005378	32.1	ZNF384, ZNF521, PIK3CA, PICALM, PIK3CG, KLF5
4	homeostasis/metabolism phenotype	MP:0005376	30.8	PIK3CA, PICALM, PIK3CG, LRP5, KLF10, KLF5
5	hematopoietic system phenotype	MP:0005397	29.8	PICALM, KIT, SFRP1, PCNA, VPREB1, BTK
6	immune system phenotype	MP:0005387	28.8	PICALM, LRP5, KLF5, NCOA3, KIT, VWF
7	nervous system phenotype	MP:0003631	24.8	LRP5, RELA, CNTNAP2, KIT, KITLG, VWF
8	cardiovascular system phenotype	MP:0005385	23.7	PIK3CA, PIK3CG, LRP5, KLF5, RELA, KIT
9	normal phenotype	MP:0002873	22.3	LRP5, KLF5, RELA, SFRP5, NAT1, BRAF
10	embryogenesis phenotype	MP:0005380	22.2	PIK3CA, PICALM, LRP5, KLF5, NCOA3, KIT
11	integument phenotype	MP:0010771	22.0	PIK3CG, KLF10, NCOA3, RELA, CNTNAP2, KIT
12	behavior/neurological phenotype	MP:0005386	21.4	PIK3CA, LRP5, NCAM1, NCOA3, CNTNAP2, KIT
13	tumorigenesis	MP:0002006	20.0	PIK3CA, KLF10, NCOA3, KIT, KITLG, BTK
14	digestive/alimentary phenotype	MP:0005381	19.1	KLF5, NCOA3, KIT, KITLG, VWF, BTK
15	skeleton phenotype	MP:0005390	18.4	ZNF384, ZNF521, PIK3CG, KLF10, RELA, KIT
16	renal/urinary system phenotype	MP:0005367	18.1	NCOA3, KIT, SELP, BRAF, LMO2, RAG1
17	endocrine/exocrine gland phenotype	MP:0005379	17.8	ZNF384, LRP5, KLF5, SFRP5, NBN, SELL
18	reproductive system phenotype	MP:0005389	17.4	ZNF384, PIK3CA, NCOA3, SFRP5, NBN, SEPT4
19	craniofacial phenotype	MP:0005382	16.6	ZNF521, LRP5, NCOA3, KIT, KITLG, NBN
20	liver/biliary system phenotype	MP:0005370	16.6	PICALM, LRP5, NCOA3, KIT, SERPINC1, VEGFA
21	vision/eye phenotype	MP:0005391	16.5	PIK3CA, LRP5, NCAM1, RELA, KIT, KITLG
22	no phenotypic analysis	MP:0003012	16.4	SFRP1, PCNA, RB1, VEGFA, BNC1, MYC
23	limbs/digits/tail phenotype	MP:0005371	16.3	LRP5, KLF10, RELA, KIT, KITLG, SFRP1
24	hearing/vestibular/ear phenotype	MP:0005377	15.7	NCOA3, KIT, KITLG, RB1, VDR, MYC
25	respiratory system phenotype	MP:0005388	15.7	KLF5, SFTPD, SELL, SELP, LPL, RAG1
26	muscle phenotype	MP:0005369	14.8	PIK3CA, PIK3CG, KLF5, NCOA3, RELA, KIT
27	adipose tissue phenotype	MP:0005375	12.9	PIK3CA, NCOA3, SFRP1, RB1, SERPINE1, BRAF
28	pigmentation phenotype	MP:0001186	12.6	LRP5, KIT, KITLG, RB1, SERPINC1, BRAF
29	other phenotype	MP:0005395	11.3	RARA, RARB, PBX1, KDR, LEPR, JAK2

Articles related to acute lymphoblastic leukemia:

(show top 50)    (show all 1353)

id	Title	Authors	Year	Affiliating Genes
1	An aggressive systemic juvenile xanthogranuloma clona lly related to a preceding T-cell acute lymphoblastic leukemia. (20848640)	Perez-Becker R.... Klapper W.	2011	TRG@
2	Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group stud y. (20459861)	Cleaver A.L.... Kees U.R.	2010	IL7R, IL7
3	IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with e xpression of proliferation and survival markers. (20060740)	Sasson S.C.... Kelleher A.D.	2010	IL2RG, IL7R, IL7
4	NF-kappaB activation mediates resistance to IFN beta in MLL-rearranged acute lymphoblastic leukemia. (20130599)	Tracey L.... Davidoff A.M.	2010	IFNB1
5	Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B- cell acute lymphoblastic leukemia. (20170710)	Schwartz J.R.... Vedeckis W.V.	2010	NR3C1
6	Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. (19139102)	Hornakova T.... Renauld J.C.	2009	IL2RA, JAK1, IL18R1
7	Pre-B cell receptor-mediated cell cycle arrest in Phi ladelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS func tion. (19620627)	Trageser D.... MA1schen M.	2009	BLNK, IKZF1
8	AML1 amplification and 17q25 deletion in a case of ch ildhood acute lymphoblastic leukemia. (19927343)	Gulten T.... GuneA9 A.M.	2009	SEPT9
9	Novel IGHalpha translocations, t(2;14)(q14.3;q32) and t(14;17)(q32;q21), in B-cell precursor acute lymphoblastic leukemia. (18656697)	Aventin A.... Mecucci C.	2008	IGH@
10	BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients. (18455790)	Jimenez-Morales S.... Orozco L.	2008	PBX1, TCF3
11	Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3- yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. (18577685)	Fala F.... Martelli A.M.	2008	CASP3
12	Role of GSTM1 (Present/Null) and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic leukemia among the South Indian population. (19256768)	Suneetha K.J.... Rajkumar T.	2008	GSTP1, GSTM1
13	Translocation (14;14)(q11;q32) with simultaneous involvement of the IGH and CEBPE genes in B-lineage acute lymphoblastic leukemia. (19027493)	Han Y.... Bai S.	2008	TCL1A
14	5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children. (18421714)	Alcasabas P.... Everson R.B.	2008	MTHFR
15	Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. (18362173)	Flex E.... Tartaglia M.	2008	JAK1, IL18R1
16	Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (17910045)	Paulsson K.... Johansson B.	2008	PTPN11, FLT3, NRAS
17	Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia. (17332311)	Infante-Rivard C.... Weinberg C.R.	2007	NQO1
18	Clinical and prognostic significance of cytokine receptor expression in adult acute lymphoblastic leukemia: interleukin-2 receptor alpha-chain predicts a poor prognosis. (17205058)	Nakase K.... Katayama N.	2007	FLT3, IL2RA, CSF1R
19	TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia. (17015828)	Sabaawy H.E.... Hickstein D.D.	2006	RUNX1, ETV6
20	Mutational screen reveals a novel JAK2 mutation, L611S, in a child with acute lymphoblastic leukemia. (16341038)	Kratz C.P.... Stanulla M.	2006	JAK2
21	High-level amplification of the RUNX1 gene in two cases of childhood acute lymphoblastic leukemia. (17011991)	Garcia-Casado Z.... Sanz M.A.	2006	RUNX1
22	Molecular cytogenetic analysis of gene rearrangements in childhood acute lymphoblastic leukemia. (15716599)	Woo H.Y.... Kim S.H.	2005	CDKN2A, MLL
23	Methemoglobinemia in children with acute lymphoblastic leukemia (ALL) receiving dapsone for pneumocystis carinii pneumonia (PCP) prophylaxis: a correlation with cytochrome b5 reductase (Cb5R) enzyme levels. (15390276)	Williams S.... Athale U.H.	2005	CYB5R3
24	Therapy-related acute lymphoblastic leukemia with MLL rearrangement following treatment of Burkitt's leukemia. (16019540)	Millot F.... Brizard A.	2005	MLL
25	Thromboembolism in adults with acute lymphoblastic leukemia during induction with L-asparaginase-containing multi-agent regimens: incidence, risk factors, and possible role of antithrombin. (15370205)	Elliott M.A.... Litzow M.R.	2004	SERPINC1
26	Mature B-cell acute lymphoblastic leukemia with t(9;11) translocation: a distinct subset of B-cell acute lymphoblastic leukemia. (15098014)	Tsao L.... Alobeid B.	2004	MYC, MLL
27	Primary acute lymphoblastic leukemia cells use a novel promoter and 5'noncoding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start. (15297414)	Flatley R.M.... Matherly L.H.	2004	SLC19A1
28	Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia. (15201966)	Matsushita C.... Taguchi H.	2004	DAPK1, RARB, CDKN2A
29	The role of breast cancer resistance protein in acute lymphoblastic leukemia. (14613996)	Plasschaert S.L.... de Vries E.G.	2003	ABCC1, ABCG2, ABCC2
30	Expression of functional markers in acute lymphoblastic leukemia. (12860010)	Oh E.J.... Han K.	2003	ABCC1, ABCB1, IL3
31	Changes of hemostatic factors in children with acute lymphoblastic leukemia receiving combined chemotherapy including high dose methylprednisolone and L-asparaginase. (10221516)	Oner A.F.... TunAs B.	1999	VWF, THBD
32	Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy. (9748136)	Zhang L.... Matherly L.H.	1998	SLC19A1
33	Relation between age, immunophenotype and in vitro dr ug resistance in 395 children with acute lymphoblastic leukemia--implications f or treatment of infants. (9737681)	Pieters R.... Veerman A.J.	1998	IDUA
34	Improving the diagnostic accuracy of cytologic cerebr ospinal fluid examinations in acute lymphoblastic leukemia using high-power mic roscopy and terminal deoxynucleotidyl transferase determinations. (9143842)	Desai K.... Wilbur D.C.	1997	DNTT
35	Human granulocyte colony-stimulating factor after induction chemotherapy in children with acute lymphoblastic leukemia. (9187068)	Pui C.H.... Evans W.E.	1997	CSF3
36	Granulocyte colony-stimulating factor as an adjunct to induction chemotherapy for adult acute lymphoblastic leukemia--a randomized phase-III study. (9226158)	Geissler K.... Lechner K.	1997	CSF2, CSF3
37	Myeloperoxidase mRNA analysis in acute lymphoblastic leukemia. (8955614)	Crisan D.... O'Malley B.	1996	BCR
38	Role of granulocyte-macrophage colony-stimulating factor in Philadelphia (Ph1)-positive acute lymphoblastic leukemia: studies on two newly established Ph1-positive acute lymphoblastic leukemia cell lines (Z-119 and Z-181). (8600166)	Estrov Z.... Kurzrock R.	1996	IL3, CSF2
39	Detection of minimal residual disease in patients with childhood common acute lymphoblastic leukemia after autologous bone marrow transplantation with ex vivo purging and systemic IL-2 infusion: unsuccessful prediction of subsequent relapse. (8535317)	Kiyoi H.... Naoe T.	1995	IL2
40	Proliferation of MIELIKI a novel t(7;9) early pre-B acute lymphoblastic leukemia cell line is inhibited concomitantly by IL-4 and IL-7. (7630198)	Renard N.... Saeland S.	1995	IL7
41	Dysregulation of HOX11 by chromosome translocations in T-cell acute lymphoblastic leukemia: a paradigm for homeobox gene involvement in human cancer. (7719228)	Lichty B.D.... Dube I.D.	1995	TLX1
42	Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. (7742527)	Fizzotti M.... Lo Coco F.	1995	CDK4, CDKN2A
43	High glucocorticoid receptor content of leukemic blasts is a favorable prognostic factor in childhood acute lymphoblastic leukemia. (8400283)	Kato G.J.... Leventhal B.G.	1993	NR3C1
44	Common acute lymphoblastic leukemia antigen expression on visceral epithelial cells in several types of glomerulonephritis. (8302714)	Ivanov A.... Paltsev M.	1993	MME
45	Expression of common acute lymphoblastic leukemia antigen (CD 10) by myelinated fibers of the peripheral nervous system. (8392520)	Cadoni A.... Zicca A.	1993	MME
46	Establishment of a new human pre-B acute lymphoblastic leukemia cell line (KMO-90) with 1;19 translocation carrying p53 gene alterations. (8412323)	Sotomatsu M.... Shitara T.	1993	CD22
47	Karyotype and T-cell receptor expression in T-lineage acute lymphoblastic leukemia. (1377008)	Secker-Walker L.M.... Coustan-Smith E.	1992	LMO2
48	Glucocorticoid receptors in acute lymphoblastic leukemia in children (1766744)	GershteA-n E.S.... Bassalyk L.S.	1991	NR3C1
49	Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions. (2528730)	D'Adamio L.... Reinherz E.L.	1989	MME
50	The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27). (2521237)	Barker P.E.... Reinherz E.L.	1989	MME

Genes related to acute lymphoblastic leukemia according to GeneCards:

(show top 50)    (show all 723)

id	Symbol	Description	Score	GeneCards Section Context
1	TSPAN7	tetraspanin 7	11.1	Publications, Aliases & Descriptions
2	TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	11.1	Publications, Summaries
3	PBX1	pre-B-cell leukemia homeobox 1	11.1	Publications, Summaries
4	IKZF1	IKAROS family zinc finger 1 (Ikaros)	11.1	Publications, Summaries
5	TAL2	T-cell acute lymphocytic leukemia 2	11.1	Publications, Functions, Summaries
6	TLX1	T-cell leukemia homeobox 1	11.1	Publications, Summaries
7	HMHB1	histocompatibility (minor) HB-1	11.1	Publications, Expressions, Functions, Summaries
8	LYL1	lymphoblastic leukemia derived sequence 1	11.1	Publications, Summaries
9	LMO2	LIM domain only 2 (rhombotin-like 1)	11.1	Publications, Summaries
10	OLIG2	oligodendrocyte lineage transcription factor 2	11.1	Publications, Summaries
11	AFF4	AF4/FMR2 family, member 4	11.1	Publications, Summaries
12	ARID5B	AT rich interactive domain 5B (MRF1-like)	11.1	Publications, Summaries
13	FLT3	fms-related tyrosine kinase 3	11.1	Publications, Functions, Summaries
14	ABCC5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	11.1	Publications, Summaries
15	BCL9	B-cell CLL/lymphoma 9	11.1	Summaries
16	BLNK	B-cell linker	11.1	Publications, Summaries
17	FLI1	Friend leukemia virus integration 1	11.1	UniProt Related, Summaries
18	MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	11.1	Summaries
19	PICALM	phosphatidylinositol binding clathrin assembly protein	11.1	Publications, Summaries
20	LALL	Lymphomatous acute lymphoblastic leukemia	11.1	Aliases & Descriptions
21	BLACE	B-cell acute lymphoblastic leukemia expressed	11.1	Aliases & Descriptions, Proteins
22	TPD52L2	tumor protein D52-like 2	11.0	Summaries
23	ZMIZ1	zinc finger, MIZ-type containing 1	11.0	Summaries
24	TAL1	T-cell acute lymphocytic leukemia 1	11.0	Publications
25	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
26	IL7	interleukin 7	11.0	Publications
27	ETV6	ets variant 6	11.0	Publications
28	HLF	hepatic leukemia factor	11.0	Publications
29	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
30	IL7R	interleukin 7 receptor	11.0	Publications
31	RUNX1	runt-related transcription factor 1	11.0	Publications, Functions
32	TCL1A	T-cell leukemia/lymphoma 1A	11.0	Publications
33	THY1	Thy-1 cell surface antigen	11.0	Publications
34	TFPT	TCF3 (E2A) fusion partner (in childhood Leukemia)	11.0	Publications
35	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
36	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	11.0	Publications
37	IL2RG	interleukin 2 receptor, gamma	11.0	Publications
38	MTAP	methylthioadenosine phosphorylase	11.0	Publications
39	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
40	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	11.0	Publications
41	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
42	MYB	v-myb myeloblastosis viral oncogene homolog (avian)	11.0	Publications
43	BAX	BCL2-associated X protein	11.0	Publications
44	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
45	LEP	leptin	11.0	Publications
46	BRCA2	breast cancer 2, early onset	11.0	Publications
47	INS	insulin	11.0	Publications
48	IGKDEL	immunoglobulin kappa deleting element or like	11.0	Publications
49	MIR1972-2	microRNA 1972-2	11.0	Publications
50	MIR1973	microRNA 1973	11.0	Publications

Pathways related to acute lymphoblastic leukemia according to GeneDecks:

(show top 50)    (show all 299)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	15.4	PIK3CG, KIT, BTK, VEGFC, CD28, CD80
2	Antioxidant Action of Vitamin-C36	15.4	KIT, KITLG, BTK, VEGFC, BMP6, BDNF
3	Lymphocyte Signaling3	14.8	NCAM1, KIT, KITLG, BTK, BMI1, RAG1
4	Apoptosis and Autophagy3	13.9	LMNB1, MYC, BIRC2, BIRC5, BIRC7, PARP1
5	Pathways in cancer20	13.8	PIK3CA, PIK3CG, RELA, RB1, BRCA2, VEGFA
6	Hematopoietic cell lineage20	13.8	KIT, KITLG, MS4A1, CD33, CD36, CD34
7	Pancreatic Adenocarcinoma36	13.7	KIT, KITLG, RB1, BRAF, BRCA2, VEGFC
8	Glucocorticoid Receptor Signaling36	13.7	NCOA3, BTK, BMP6, BCL2, BAX, CEBPA
9	ERK Signaling36	13.7	KIT, KITLG, BTK, BRAF, VEGFC, MYC
10	Cellular Apoptosis Pathway36	12.8	KIT, KITLG, VEGFC, VDAC1, BMP6, BIRC2
11	Paxillin Interactions36	12.7	KIT, KITLG, VEGFC, BDNF, KDR, ITGA5
12	Endothelin-1 Signaling Pathway36	12.7	KIT, BTK, BRAF, MYC, BMP6, CD80
13	p70S6K Signaling36	12.6	KIT, KITLG, VEGFC, BMP6, BDNF, KDR
14	Phospholipase-C Pathway36	12.6	KIT, KITLG, BTK, VEGFC, BMP6, BLNK
15	Measles20	12.5	PIK3CA, PIK3CG, RELA, JAK1, JAK2, CDK6
16	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	12.2	MTRR, MTHFR, MTR, MTHFD1, FPGS, SHMT1
17	Nanog in Mammalian ESC Pluripotency36	12.2	KIT, KITLG, BRAF, VEGFC, BMP6, BDNF
18	CREB Pathway36	12.2	KIT, KITLG, BMP6, BDNF, KDR, FLT4
19	p53 Mediated Apoptosis36	12.2	KIT, KITLG, VEGFC, BMP6, BDNF, KDR
20	DHA Signaling36	12.1	KIT, KITLG, VEGFC, BMP6, BDNF, KDR
21	Cyclins and Cell Cycle Regulation36	12.0	RB1, ATM, CDK6, CDKN1A, CDKN2C, CDK2
22	Immune response IL-22 signaling pathway10	12.0	MYC, BCL2, BCL2L1, JUN, JAK1, JAK2
23	Apoptosis20	11.9	PIK3CA, PIK3CG, RELA, BIRC2, BCL2, BCL2L1
24	P2Y Receptor Signaling36	11.9	KIT, BRAF, VEGFC, MYC, KDR, JUN
25	G1-S Phase Transition36	11.9	RB1, ATM, CDK6, CDKN1A, CDKN2C, CDK2
26	Immune response_IL-22 signaling pathway41	11.9	MYC, BCL2, BCL2L1, JUN, JAK1, JAK2
27	Intestinal immune network for IgA production20	11.8	CD28, CD40LG, CD80, CD40, IL10, IL15
28	Signal transduction_AKT signaling41	11.7	PIK3CA, RELA, PCNA, MYC, BCL2L1, BCL2L11
29	Telomerase Components in Cell Signaling36	11.7	KIT, KITLG, RB1, VEGFC, MYC, BMP6
30	Development_IGF-1 receptor signaling41	11.7	PIK3CA, RELA, MYC, BCL2L1, MTOR, MAPK3
31	Apoptosis and survival_TNFR1 signaling pathway41	11.6	RELA, BIRC2, BCL2, BAX, XIAP, JUN
32	IL-2 Pathway36	11.6	MYC, LCK, JUN, JAK1, FOS, IL2
33	Rac1 Pathway36	11.6	KITLG, BMP6, BDNF, KDR, JUN, ITGA5
34	Apoptosis and survival TNFR1 signaling pathway10	11.5	RELA, BIRC2, BAX, XIAP, JUN, APAF1
35	Tuberculosis20	11.5	RELA, VDR, BCL2, BAX, JAK1, JAK2
36	Actin-Based Motility by Rho Family GTPases36	11.5	BDNF, ITGA6, ITGAL, ITGAM, IL2, IGF1
37	TNF Superfamily Pathway36	11.4	JUN, FOS, FADD, MAPK8, MAPK12, MAPK14
38	THC Differentiation Pathway36	11.3	CD28, IL10, IL10RA, IL12A, IL12B, IL12RB1
39	Development PDGF signaling via STATs and NF-kB10	11.2	PIK3CA, RELA, MYC, JAK1, JAK2, FOS
40	TRAF Pathway36	11.1	BIRC2, UBC, JUN, FOS, IL12A, IL12B
41	Influenza A20	11.1	PIK3CA, PIK3CG, RELA, VDAC1, JUN, JAK1
42	Osteoclast differentiation20	11.0	PIK3CA, PIK3CG, RELA, BTK, LILRB1, BLNK
43	TGF-beta Signaling Pathways37	10.9	PIK3CG, RELA, BRAF, MYC, MTOR, JUN
44	Development_Prolactin receptor signaling41	10.9	PIK3CA, RELA, MYC, BCL2, BCL2L1, JUN
45	Focal adhesion20	10.9	PIK3CA, PIK3CG, VWF, BRAF, VEGFC, BIRC2
46	Colorectal cancer20	10.9	PIK3CG, BRAF, MSH2, MSH3, FOS, MAPK8
47	Hepatitis C20	10.8	PIK3CA, PIK3CG, RELA, BRAF, JAK1, CDKN1A
48	Bladder cancer20	10.8	RB1, BRAF, VEGFA, VEGFC, MYC, CDKN1A
49	Colorectal Cancer Metastasis36	10.6	LRP5, BRAF, MYC, BIRC5, BCL2L1, BAX
50	Development_VEGF signaling and activation41	9.6	PIK3CA, RELA, VEGFA, RASA1, KDR, JUN

Compounds related to acute lymphoblastic leukemia according to GeneDecks:

(show top 50)    (show all 461)

id	Compound	Score	Top Affiliating Genes
1	estrogen32	18.4	LRP5, COG2, KLF10, KLF5, NCOA3, VWF
2	progesterone32 42 9 18 9	21.4	PIK3CA, NCAM1, NCOA3, KIT, PCNA, RB1
3	wortmannin32 42	16.4	PIK3CA, PIK3CG, KITLG, BTK, BRAF, RAD51
4	hydrogen32 18	16.4	KIR3DL1, BTK, RAD51, RARA, CLIP1, BDNF
5	threonine32	15.1	BTK, NBN, SET, PARK2, ZAP70, LCK
6	butyrate32	15.1	NCOA3, KITLG, PCNA, RB1, VDR, MYC
7	imatinib32 34 9 9	18.0	PIK3CA, PIK3CG, KIT, KITLG, SELL, BRAF
8	ethanol32 34 9 18 9	18.0	NCAM1, KITLG, RARB, BDNF, LEPR, MTR
9	polysaccharide32	13.7	NCAM1, NCOA3, KITLG, SFTPD, SELL, SELP
10	aspartate32	13.7	PCNA, SELP, BRAF, VDR, BMP6, RAG1
11	ionomycin32	13.7	BTK, LMNB1, RAG1, CLIP1, LCK, CDK6
12	fludarabine32 9 9	15.6	BIRC2, BIRC5, PARP1, BCL2, BCL2L1, ZAP70
13	bromodeoxyuridine32	13.5	PIK3CA, NCAM1, NCOA3, KITLG, PCNA, BTK
14	tamoxifen32 34 9 9	16.3	PIK3CA, NCOA3, PCNA, SERPINC1, SERPINB9, BRCA2
15	chloramphenicol32 9 9	15.3	SERPINC1, SERPINE1, LPL, VDR, MYC, MYB
16	endotoxin32	13.3	SFTPD, SELL, SERPINF2, LEPR, CHKB, JAK2
17	mitomycin c32	13.1	VWF, PCNA, RB1, NBN, BRCA2, RAD51
18	p00232	13.1	KIT, RB1, BRAF, BRCA2, BIRC5, LEP
19	quercetin32 42 9 18 9	17.0	PIK3CA, PIK3CG, BIRC5, PARP1, BCL2, BCL2L1
20	cytidine32 9 18 9	16.0	MYC, RAG1, PAX5, ZAP70, UCK2, CD79A
21	okadaic acid32 42	13.4	PIK3CA, RELA, RB1, MYC, MYB, BMP6
22	glycerol32 9 18 9	15.4	VWF, PCNA, SERPINC1, LPL, VDAC1, LEP
23	dmso32	12.3	KITLG, SELP, BMP6, XDH, CD36, ITGAM
24	depsipeptide32	12.3	KITLG, RB1, BRAF, MYC, BCL2, BCL2L1
25	thyroxine32 18	13.1	COG2, VWF, PCNA, SERPINF2, LPL, VDR
26	acetaminophen32 34 9 18 9	16.0	PCNA, NAT2, MYC, BCL2L1, UGT1A1, B2M
27	adpribose32	11.9	PIK3CA, PIK3CG, PCNA, RB1, BRCA2, LMNB1
28	6 mercaptopurine32	11.9	UGT1A1, MTHFR, XDH, MSH2, ITPA, FPGS
29	warfarin32 34 9 18 9	15.9	VWF, SELP, SERPINC1, NAT2, BGLAP, MTHFR
30	oxaliplatin32 34 9 9	14.8	VEGFA, BIRC5, BCL2L1, UGT1A1, MTHFR, XRCC1
31	dasatinib32 34 9 9	14.6	KIT, BCL2L1, BCR, LCK, MCL1, CYP1A1
32	trastuzumab32 34 9 9	14.6	PIK3CA, PIK3CG, KIT, VEGFC, BIRC5, KDR
33	sodium dodecylsulfate32	11.6	VWF, SERPINF2, SERPINE1, LPL, VDAC1, MYC
34	herbimycin a32 42	12.5	PIK3CG, KITLG, SELL, MYC, BMP6, LCK
35	sulforaphane32	11.4	PIK3CG, RB1, PARP1, UGT1A1, JUN, CDKN1A
36	octreotide32 42 9 9	14.3	VEGFA, MPO, MME, MMP2, INS, INSR
37	egcg32	11.3	PIK3CG, BCL2L1, UGT1A1, XIAP, CDK6, CDK2
38	indomethacin32 9 9	13.3	PCNA, SELL, LPL, MYC, BMP6, BIRC5
39	okt332	11.3	BMP6, ZAP70, LCK, CD79A, CD40LG, ITGB2
40	progestin32	11.2	SERPINC1, VEGFA, KDR, CDK6, CDK4, FKBP5
41	nicotine32 34 9 9	14.2	RB1, SELL, BIRC5, UGT1A1, CCR7, GPT
42	resveratrol32 9 18 9	14.2	PIK3CA, PIK3CG, PCNA, RB1, BSG, BRCA2
43	vitamin b1232	11.1	VWF, PCNA, MTRR, MTHFR, MTR, B2M
44	betulinic acid32	11.0	BIRC5, PARP1, BCL2, BCL2L1, MCL1, ANXA5
45	vitamin e succinate32	10.8	MYC, BMP6, PARP1, BCL2, BCL2L1, BAX
46	staurosporin32	10.6	PIK3CA, PIK3CG, BCL2, BCL2L1, JUN, CDKN3
47	anisomycin32 42 9 9	13.4	PIK3CG, MYC, BDNF, MTOR, JUN, FOS
48	gf 109203x32 42	11.1	PIK3CG, KITLG, BTK, VEGFA, JUN, JAK2
49	gm-csf32	10.1	KITLG, VEGFA, BMP6, BCL2L1, IL10, IL11
50	ciglitazone32	9.5	SERPINE1, RARA, RARB, PARP1, BCL2L1, BAX

Cellular components related to acute lymphoblastic leukemia according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	32.8	ZNF384, ZNF521, PICALM, KLF10, KLF5, NCOA3
2	cytoplasm	GO:005737	26.5	PIK3CG, NCOA3, RELA, KIT, KITLG, PCNA
3	plasma membrane	GO:005886	23.4	PIK3CG, LRP5, NCAM1, KIT, KITLG, KIR3DL1
4	cytosol	GO:005829	23.4	PIK3CA, PIK3CG, PDE1A, RELA, SFRP1, BTK
5	nucleolus	GO:005730	18.1	ZNF384, KLF5, NCOA3, PCNA, RBM39, NBN
6	integral to plasma membrane	GO:005887	17.2	KIR3DL1, SELL, SELP, KDR, SCARB2, UGT1A1
7	nucleoplasm	GO:005654	15.7	RFC1, NCOA3, RELA, PCNA, RB1, RBM39
8	extracellular region	GO:005576	15.5	NCAM1, KITLG, VWF, SFTPD, VPREB1, SERPINC1
9	extracellular space	GO:005615	14.7	KIT, KITLG, SFRP1, SFRP5, SFTPD, SELP
10	membrane	GO:016020	13.2	PIK3CG, CNTNAP2, VEGFA, VEGFC, VDAC1, RAB6A
11	external side of plasma membrane	GO:009897	13.1	NCAM1, KIT, VWF, SELL, SELP, LILRB1

Biological processes related to acute lymphoblastic leukemia according to GeneDecks:

(show top 50)    (show all 57)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	17.6	PIK3CA, PIK3CG, NCOA3, BSG, NAT1, NAT2
2	signal transduction	GO:007165	16.6	PDE1A, CNTNAP2, KIT, KITLG, SFRP5, VEGFC
3	positive regulation of transcription from RNA polymerase II promoter	GO:045944	15.6	LRP5, NCOA3, RELA, RB1, SERPINF2, SERPINE1
4	positive regulation of cell proliferation	GO:008284	15.5	LRP5, KLF5, KIT, SFRP1, NBN, VEGFA
5	immune response	GO:006955	15.2	KIR3DL1, VPREB1, SERPINB9, BMP6, RAG1, ZAP70
6	cell proliferation	GO:008283	14.5	KLF10, KITLG, PCNA, NBN, RAPGEF3, LIG4
7	positive regulation of transcription, DNA-dependent	GO:045893	14.5	PICALM, LRP5, KLF5, NCOA3, RELA, SFRP1
8	negative regulation of transcription from RNA polymerase II promoter	GO:000122	14.4	KLF10, VDR, LMO1, MYC, MYB, BMI1
9	apoptotic process	GO:006915	14.1	SFRP5, BTK, NBN, SEPT4, VDAC1, LMNB1
10	negative regulation of cell proliferation	GO:008285	13.8	KLF10, SFRP1, SFRP5, BTG1, VDR, RARB
11	cell-cell signaling	GO:007267	13.6	KLF10, CEACAM6, CD33, CD70, CD80, ITGB2
12	negative regulation of apoptotic process	GO:043066	13.4	PIK3CG, RELA, SFRP1, SERPINE1, BRAF, VEGFA
13	negative regulation of transcription, DNA-dependent	GO:045892	13.0	RELA, SFRP1, RB1, SET, VDR, MYB
14	virus-host interaction	GO:019048	12.8	RELA, RB1, VDAC1, RAN, KDR, LCK
15	blood coagulation	GO:007596	12.6	PIK3CA, PIK3CG, PDE1A, VWF, SELL, SELP
16	cytokine-mediated signaling pathway	GO:019221	12.6	NCAM1, RELA, KIT, UBC, MT2A, B2M
17	anti-apoptosis	GO:006916	12.6	PIK3CA, RELA, SERPINB9, BRAF, BIRC2, BIRC5
18	induction of apoptosis	GO:006917	12.6	KLF10, BCL2L11, BCL2L13, LCK, BAX, CDKN2C
19	response to drug	GO:042493	12.4	SFRP1, NBN, VEGFC, LPL, MYC, BGLAP
20	positive regulation of apoptotic process	GO:043065	12.3	SFRP1, SEPT4, RARB, LILRB1, BCL2L11, BAK1
21	cell surface receptor signaling pathway	GO:007166	12.2	BSG, BIRC2, LEPR, MPL, CD28, CD27
22	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	12.1	MYC, BCL2L11, BCL2L13, LCK, BAX, XDH
23	B cell differentiation	GO:030183	12.1	RAG1, BLNK, BCL11A, MSH2, CD79A, CD40LG
24	cell cycle arrest	GO:007050	12.0	RB1, NBN, MYC, MSH2, ATM, CDK6
25	peptidyl-tyrosine phosphorylation	GO:018108	12.0	KIT, BTK, KDR, ZAP70, JAK1, JAK2
26	positive regulation of gene expression	GO:010628	12.0	NCOA3, KIT, BRAF, VEGFA, VDR, LILRB1
27	G1 phase of mitotic cell cycle	GO:000080	11.9	RB1, UBC, CDK6, CDKN1A, CDKN2C, CDKN2B
28	leukocyte migration	GO:050900	11.9	PIK3CA, SELL, SELP, BSG, LCK, CD34
29	response to lipopolysaccharide	GO:032496	11.8	SELP, UGT1A1, JUN, JAK2, MMP9, IL12A
30	response to ethanol	GO:045471	11.7	BGLAP, BCL2, BAK1, CD27, CDK1, MMP9
31	positive regulation of MAPK cascade	GO:043410	11.7	KIT, KDR, LEP, CD36, CDH2, ITGB1
32	nerve growth factor receptor signaling pathway	GO:048011	11.7	PIK3CA, PDE1A, RELA, BRAF, BCL2L11, UBC
33	induction of apoptosis by extracellular signals	GO:008624	11.6	BTK, VDR, BCL2L11, UBC, BAK1, BAX
34	liver development	GO:001889	11.6	VWF, UGT1A1, CEBPA, JUN, ASNS, ARID5B
35	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	11.5	KITLG, VEGFA, MTOR, JAK2, CD36, CD81
36	angiogenesis	GO:001525	11.5	PIK3CA, PIK3CG, KLF5, SERPINE1, VEGFA, VEGFC
37	fibroblast growth factor receptor signaling pathway	GO:008543	11.5	PIK3CA, PDE1A, BRAF, UBC, MTOR, CDKN1B
38	response to hypoxia	GO:001666	11.5	VEGFA, USF1, BCL2, LEP, XRCC1, ATM
39	induction of apoptosis by intracellular signals	GO:008629	11.3	MYC, BCL2, BCL2L1, BCL2L11, BAK1, BAX
40	positive regulation of B cell proliferation	GO:030890	11.3	BCL2, CDKN1A, CD40LG, CD40, CD38, MEF2C
41	epidermal growth factor receptor signaling pathway	GO:007173	11.2	PIK3CA, PDE1A, UBC, MTOR, CDKN1B, CDK1
42	humoral immune response	GO:006959	11.1	BLNK, PAX5, BCL2, MS4A2, CD28, MEF2C
43	inflammatory response	GO:006954	11.0	PIK3CG, RELA, KIT, SELP, BMP6, BLNK
44	response to estradiol stimulus	GO:032355	10.8	BRCA2, VDR, RARA, MMP9, INSR, IL1B
45	aging	GO:007568	10.7	VDR, BAK1, JUN, IL15, IL1B, FAS
46	response to organic cyclic compound	GO:014070	10.7	SFRP1, SELP, UGT1A1, BAK1, MSH2, JUN
47	positive regulation of protein phosphorylation	GO:001934	10.7	VEGFA, MTOR, CD40, FLT4, INSR, IL1B
48	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	10.6	NCOA3, KIT, JAK2, ARID5B, IL10, IL1B
49	platelet activation	GO:030168	10.4	PIK3CA, PIK3CG, VWF, SELP, SERPINF2, SERPINE1
50	positive regulation of smooth muscle cell proliferation	GO:048661	10.0	SERPINF2, JUN, FLT1, IL6, IL6R, IGF1

Molecular functions related to acute lymphoblastic leukemia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	36.4	EPOR, LYL1, RORA, ROR1, NKX3-1, NKX2-5
2	sequence-specific DNA binding transcription factor activity	GO:003700	18.6	AFF1, EP300, HDAC1, EBF1, RORA, NKX3-1
3	sequence-specific DNA binding	GO:043565	16.1	STAT3, NR3C1, SP1, SRF, DLX4, TP73
4	protein homodimerization activity	GO:042803	13.9	ADRB2, BCL11A, CLIP1, BIRC5, USF1, LILRB1
5	protein heterodimerization activity	GO:046982	13.2	NKX2-5, ENO2, MCL1, APOE, APOB, IL12B
6	transcription factor binding	GO:008134	13.1	TCF3, DNMT1, AHR, HES1, NFKBIA, CREBBP
7	protein kinase binding	GO:019901	13.0	MSH2, JAK2, CDKN2C, CDH2, CDKN2D, LCK
8	enzyme binding	GO:019899	11.8	RARA, BTG1, CNTNAP2, USF1, LYN, CSF3
9	transcription regulatory region DNA binding	GO:044212	11.5	AHR, WT1, NFKB1, CTNNB1, SP1, DLX5
10	protease binding	GO:002020	11.4	CD28, UBC, BCL2, BRCA2, SERPINE1, SERPINF2
11	cytokine activity	GO:005125	11.1	IL6, IL7, IFNA2, IFNB1, IFNG, TNF
12	growth factor activity	GO:008083	10.9	IGF2, MDK, IL7, IL6, IL4, IL3