MCID: ACT103
MIFTS: 53

Acute Lymphoblastic Leukemia, Childhood

Categories: Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Acute Lymphoblastic Leukemia, Childhood

MalaCards integrated aliases for Acute Lymphoblastic Leukemia, Childhood:

Name: Acute Lymphoblastic Leukemia, Childhood 37
Childhood Acute Lymphocytic Leukemia 12 49 14
Childhood Acute Lymphoblastic Leukemia 12 49
Pediatric Acute Lymphoblastic Leukemia 49
Lymphoblastic Leukemia Acute Childhood 51
Leukemia, Lymphocytic, Acute, L1 69
Childhood All 49

Classifications:



External Ids:

Disease Ontology 12 DOID:0080144
NCIt 46 C3168
UMLS 69 C0023452

Summaries for Acute Lymphoblastic Leukemia, Childhood

NIH Rare Diseases : 49 Childhood acute lymphoblastic leukemia (ALL) is a type of cancer of the blood and bone marrow, and the most common type of cancer in children. In children with this condition, too many stem cells made by the bone marrow become lymphoblasts, B lymphocytes, or T lymphocytes. These cells do not function normally and have trouble fighting off infections. Signs and symptoms may include fever; easy bruising or bleeding; bone or joint pain; painless lumps in the neck, underarm, stomach, or groin; weakness; fatigue; and/or loss of appetite. Treatment depends on several factors and may include combination chemotherapy, targeted therapy, and/or stem cell transplant. On August 30 2017, Kymriah became the first gene therapy approved by the FDA. Kymriah is now an option for children and young adults up to 25 years old with B-Cell precursor ALL that has proven resistant to other treatments or has relapsed two or more times. Last updated: 9/18/2017

MalaCards based summary : Acute Lymphoblastic Leukemia, Childhood, also known as childhood acute lymphocytic leukemia, is related to leukemia and central nervous system leukemia. An important gene associated with Acute Lymphoblastic Leukemia, Childhood is ETV6 (ETS Variant 6), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Asparaginase and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 An acute lymphocytic leukemia occuring during childhood.

Related Diseases for Acute Lymphoblastic Leukemia, Childhood

Diseases related to Acute Lymphoblastic Leukemia, Childhood via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 leukemia 30.5 CDKN2A ETV6 FLT3 MME RUNX1
2 central nervous system leukemia 30.3 MME RUNX1
3 lymphoblastic leukemia 29.9 CDKN2A ETV6 FLT3 RUNX1
4 acute lymphocytic leukemia 27.1 ABCB1 ASNS CDKN2A CDKN2B ETV6 GSTM1
5 b-cell childhood acute lymphoblastic leukemia 12.6
6 t-cell childhood acute lymphocytic leukemia 12.2
7 platelet disorder, familial, with associated myeloid malignancy 10.6 ETV6 RUNX1
8 methotrexate toxicity or dose selection 10.5 MTHFR SLC19A1
9 upper thoracic spina bifida cystica 10.5 MTHFD1 MTHFR
10 cervicothoracic spina bifida cystica 10.5 MTHFD1 MTHFR
11 cervical spina bifida cystica 10.5 MTHFD1 MTHFR
12 lumbosacral spina bifida cystica 10.5 MTHFD1 MTHFR
13 thoracolumbosacral spina bifida cystica 10.5 MTHFD1 MTHFR
14 total spina bifida cystica 10.5 MTHFD1 MTHFR
15 upper thoracic spina bifida aperta 10.5 MTHFD1 MTHFR
16 thoracolumbosacral spina bifida aperta 10.5 MTHFD1 MTHFR
17 lumbosacral spina bifida aperta 10.5 MTHFD1 MTHFR
18 cervical spina bifida aperta 10.5 MTHFD1 MTHFR
19 cervicothoracic spina bifida aperta 10.4 MTHFD1 MTHFR
20 total spina bifida aperta 10.4 MTHFD1 MTHFR
21 lymphoid leukemia 10.4 ETV6 RUNX1
22 fallopian tube endometrioid adenocarcinoma 10.4 CDKN2A MME
23 tenosynovial giant cell tumor 10.4 CDKN2A CDKN2B
24 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.4 FLT3 RUNX1
25 hemifacial spasm 10.4 MTHFR TYMS
26 squamous cell carcinoma of the larynx 10.4 CDKN2A GSTM1
27 thyroid lymphoma 10.3 CDKN2A CDKN2B
28 scrotal carcinoma 10.3 CDKN2A CDKN2B
29 atypical neurofibroma 10.3 CDKN2A CDKN2B
30 mn1 10.3 ETV6 FLT3
31 cholangiolocellular carcinoma 10.2 ABCB1 CDKN2A
32 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.2 ETV6 FLT3 RUNX1
33 chronic myelomonocytic leukemia 10.2 ETV6 FLT3 RUNX1
34 pediatric osteosarcoma 10.2 MTHFR SLC19A1
35 anal canal carcinoma 10.2 CDKN2A NQO1
36 bone marrow cancer 10.2 ETV6 FLT3 RUNX1
37 papilloma 10.1 CDKN2A CDKN2B TYMS
38 hearing loss, noise-induced 10.0 GSTM1 GSTT1
39 differentiated thyroid carcinoma 10.0 CDKN2A ETV6 MTHFR XRCC1
40 childhood leukemia 10.0 ETV6 MTHFR NQO1 RUNX1
41 leukemia, chronic myeloid 10.0 ABCB1 ETV6 FLT3 RUNX1
42 gastric cardia carcinoma 9.9 MTHFR XRCC1
43 isolated cleft lip 9.9 GSTM1 GSTT1
44 cerebritis 9.9
45 hyperglycemia 9.9
46 plasmablastic lymphoma 9.9 ABCB1 CDKN2A
47 neural tube defects 9.9 MTHFD1 MTHFR SLC19A1 TYMS
48 arteritic anterior ischemic optic neuropathy 9.9 GSTM1 GSTT1 MTHFR
49 ischemic optic neuropathy 9.9 GSTM1 GSTT1 MTHFR
50 gastrointestinal stromal tumor 9.8 CDKN2A FLT3 MTHFR

Graphical network of the top 20 diseases related to Acute Lymphoblastic Leukemia, Childhood:



Diseases related to Acute Lymphoblastic Leukemia, Childhood

Symptoms & Phenotypes for Acute Lymphoblastic Leukemia, Childhood

MGI Mouse Phenotypes related to Acute Lymphoblastic Leukemia, Childhood:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.27 SLC19A1 NQO1 TPMT NR3C1 XRCC1 RUNX1
2 homeostasis/metabolism MP:0005376 10.25 SLC19A1 NQO1 TPMT NR3C1 XRCC1 RUNX1
3 hematopoietic system MP:0005397 10.21 SLC19A1 NQO1 TPMT NR3C1 RUNX1 CDKN2B
4 immune system MP:0005387 10.11 RUNX1 SLC19A1 NQO1 NR3C1 MTHFD1 CDKN2B
5 endocrine/exocrine gland MP:0005379 10.08 RUNX1 SLC19A1 NR3C1 CDKN2B ABCB1 ETV6
6 integument MP:0010771 9.97 RUNX1 MTHFR SLC19A1 NQO1 NR3C1 CDKN2B
7 mortality/aging MP:0010768 9.93 RUNX1 MTHFR SLC19A1 TPMT XRCC1 NR3C1
8 liver/biliary system MP:0005370 9.8 RUNX1 SLC19A1 NQO1 NR3C1 ABCB1 CDKN2A
9 neoplasm MP:0002006 9.5 RUNX1 NQO1 XRCC1 CDKN2B ETV6 FLT3
10 no phenotypic analysis MP:0003012 9.23 RUNX1 MTHFR NR3C1 CDKN2B ABCB1 ETV6

Drugs & Therapeutics for Acute Lymphoblastic Leukemia, Childhood

Drugs for Acute Lymphoblastic Leukemia, Childhood (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 374)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
3
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
5
Idarubicin Approved Phase 4,Phase 3,Phase 2 58957-92-9 42890
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
7
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
8
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
10
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
11 Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
12
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
13
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
16
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
17
Oprelvekin Approved, Investigational Phase 4 145941-26-0
18
Budesonide Approved Phase 4 51333-22-3 5281004 63006
19
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
20
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
21
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
22
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
24
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
25
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
27
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
28
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
31 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
32 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
33 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
34 Antibodies Phase 4,Phase 3,Phase 1,Phase 2
35
Ethylene Phase 4 74-85-1 6325
36 Immunoglobulins Phase 4,Phase 3,Phase 1,Phase 2
37 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
41 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
42 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
44 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
45 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
46 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
47 Hormones Phase 4,Phase 3,Phase 2,Phase 1
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
49 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
50
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 475)

# Name Status NCT ID Phase Drugs
1 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
2 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
3 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
4 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
5 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
6 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
7 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
8 Inhaled Steroids for Pediatric Asthma at Pediatric Emergency Medicine Discharge Recruiting NCT03369847 Phase 4 budesonide, beclomethasone
9 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
10 Intranasal Ketamine for Anxiolysis in Pediatric Emergency Department Patients Recruiting NCT03043430 Phase 4 Ketamine 100 MG/ML;Midazolam 5 MG/ML
11 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
12 Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO Not yet recruiting NCT03318393 Phase 4 Bivalirudin;Unfractionated heparin
13 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
14 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
15 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
16 ALL-SCT BFM International- HSCT in Children and Adolescents With ALL Unknown status NCT01423500 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
17 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
18 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia Unknown status NCT00002499 Phase 2, Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;dexamethasone;methotrexate;prednisone;vincristine sulfate
19 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
20 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
21 Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00002816 Phase 3 cytarabine;dexamethasone;etoposide;idarubicin;ifosfamide;leucovorin calcium;mesna;pegaspargase;therapeutic hydrocortisone;thioguanine;vincristine sulfate;Methotrexate
22 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3 6MPindividualized;6MPfixed
23 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase Completed NCT00819351 Phase 3 PEG Asparaginase at six weeks interval;PEG Asparaginase at two weeks interval
24 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005585 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
25 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00022737 Phase 3 asparaginase;cyclophosphamide;cyclosporine;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;ifosfamide;imatinib mesylate;leucovorin calcium;mercaptopurine tablet;methotrexate;pegaspargase;vincristine sulfate
26 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00613457 Phase 3 dexamethasone;asparaginase;Asparaginase;cyclophosphamide;cytarabine;daunorubicin;doxorubicin;Etoposide;Ifosfamide;mercaptopurine;Methotrexate;prednisone;thioguanine;Vincristine;Vindesine
27 A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors Completed NCT00186901 Phase 3 Calcium carbonate (Tums), vitamin D
28 Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005945 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
29 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
30 Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia Completed NCT00015873 Phase 3 asparaginase;cytarabine;mercaptopurine;methotrexate;prednisolone;vincristine sulfate
31 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00005596 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
32 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005603 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
33 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed NCT00381680 Phase 3 vincristine sulfate;prednisone;doxorubicin hydrochloride;pegaspargase;cytarabine;methotrexate;dexamethasone;etoposide;cyclophosphamide;leucovorin calcium;asparaginase;mercaptopurine
34 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00002744 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisone;therapeutic hydrocortisone;thioguanine;vincristine sulfate
35 Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
36 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
37 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
38 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
39 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
40 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
41 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
42 Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical Trial Completed NCT00750009 Phase 3
43 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
44 Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation Completed NCT01371656 Phase 3 levofloxacin
45 Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission Completed NCT00002534 Phase 3 cyclophosphamide;cytarabine;methylprednisolone;thiotepa
46 Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation Completed NCT00004255 Phase 2, Phase 3 cyclophosphamide;fludarabine phosphate;methylprednisolone;tacrolimus
47 TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma Completed NCT00002757 Phase 3 cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;methotrexate;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
48 Ondansetron in Treating Patients With Advanced Cancer and Chronic Nausea and Vomiting Not Caused by Cancer Treatment Completed NCT00006348 Phase 3 ondansetron
49 A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families Completed NCT00782145 Phase 3
50 Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia Completed NCT00005977 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate

Search NIH Clinical Center for Acute Lymphoblastic Leukemia, Childhood

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Acute Lymphoblastic Leukemia, Childhood:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Acute Lymphoblastic Leukemia, Childhood:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Acute Lymphoblastic Leukemia, Childhood

Anatomical Context for Acute Lymphoblastic Leukemia, Childhood

MalaCards organs/tissues related to Acute Lymphoblastic Leukemia, Childhood:

38
Bone, Bone Marrow, T Cells, Myeloid, B Cells, Kidney, Testes

Publications for Acute Lymphoblastic Leukemia, Childhood

Articles related to Acute Lymphoblastic Leukemia, Childhood:

(show all 50)
# Title Authors Year
1
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. ( 27301866 )
2016
2
Comparative study of quality of life of adult survivors of childhood acute lymphocytic leukemia and Wilms' tumor. ( 26537509 )
2015
3
Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia. ( 23433104 )
2013
4
Pyrethroid pesticide exposure and risk of childhood acute lymphocytic leukemia in Shanghai. ( 23153377 )
2012
5
[Relationship between genetic polymorphism of multidrug resistance 1 gene and the risk of childhood acute lymphocytic leukemia]. ( 23158821 )
2012
6
Exposure to magnetic fields and childhood acute lymphocytic leukemia in SALo Paulo, Brazil. ( 21840286 )
2011
7
Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses. ( 19953649 )
2010
8
Monitoring treatment response of childhood acute lymphocytic leukemia with certain molecular and biochemical markers. ( 21182165 )
2010
9
High incidence of Epstein Barr virus infection in childhood acute lymphocytic leukemia: a preliminary study. ( 20090225 )
2010
10
Isolated extramedullary relapse in childhood acute lymphocytic leukemia. ( 20717757 )
2010
11
High incidence of Epstein-Barr virus infection in childhood acute lymphocytic leukemia. ( 21045472 )
2010
12
Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia. ( 18667478 )
2009
13
Transient hyperglycemia during childhood acute lymphocytic leukemia chemotherapy: an old event revisited. ( 19701154 )
2009
14
Intractable epilepsy in patients treated for childhood acute lymphocytic leukemia. ( 19041267 )
2009
15
Hyperglycemia during induction therapy is associated with increased infectious complications in childhood acute lymphocytic leukemia. ( 18523991 )
2008
16
[Detection of human cyclin C gene expression in childhood acute lymphocytic leukemia using real-time fluorescence quantitative PCR]. ( 18289462 )
2008
17
Shortage of chemotherapeutic agents in Iraq and outcome of childhood acute lymphocytic leukemia, 1990-2002. ( 18650525 )
2008
18
[Expression of WAVE1 in childhood acute lymphocytic leukemia and in the apoptosis of Jurkat cells induced by adriamycin]. ( 18947485 )
2008
19
Socioeconomic status and childhood acute lymphocytic leukemia incidence in SALo Paulo, Brazil. ( 18688860 )
2008
20
Clinical role of bone marrow angiogenesis in childhood acute lymphocytic leukemia. ( 17461513 )
2007
21
A meta-analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia. ( 16628558 )
2007
22
Childhood acute lymphocytic leukemia and perspectives on risk assessment of early-life stage exposures. ( 17049456 )
2006
23
Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. ( 16923565 )
2006
24
Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia. ( 16154856 )
2005
25
Secondary malignant neoplasms of the bladder after cyclophosphamide treatment for childhood acute lymphocytic leukemia. ( 14752871 )
2004
26
Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): a cytogenetic, morphologic, and immunophenotypic study. ( 14623459 )
2003
27
Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States). ( 11899114 )
2002
28
Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic leukemia. ( 11154214 )
2001
29
Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. ( 10194447 )
1999
30
On the prognostic value of systemic methotrexate clearance in childhood acute lymphocytic leukemia. ( 9225071 )
1997
31
Salvage therapy for relapsed or refractory childhood acute lymphocytic leukemia by alternative administration a lymphoid- and myeloid-directed chemotherapeutic regimen consisting of dual modulation of ara-C, hydroxyurea, and etoposide. ( 9393595 )
1997
32
ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia. ( 9305598 )
1997
33
Hepatotoxicity of 6-mercaptopurine in childhood acute lymphocytic leukemia: pharmacokinetic characteristics. ( 8531858 )
1996
34
Malignant external otitis as the presentation of childhood acute lymphocytic leukemia. ( 8970229 )
1996
35
Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia. ( 8622065 )
1996
36
Epidemiological characteristics of childhood acute lymphocytic leukemia. Analysis by immunophenotype. The Childrens Cancer Group. ( 8182942 )
1994
37
Epidemiological characteristics of childhood acute lymphocytic leukemia. ( 7934179 )
1994
38
Changes in lactate dehydrogenase isoenzymes associated with relapse of childhood acute lymphocytic leukemia. ( 7826848 )
1994
39
Childhood acute lymphocytic leukemia with a preleukemic phase: report of an associated translocation and review of the literature. ( 8260901 )
1993
40
Adult and childhood acute lymphocytic leukemia: are they different diseases? ( 8416287 )
1993
41
Clinical trials of teniposide (VM-26) in childhood acute lymphocytic leukemia. ( 1411639 )
1992
42
Neonatal exposure to protoporphyrin-activating lighting as a contributing cause of childhood acute lymphocytic leukemia. ( 1617127 )
1992
43
Abnormal cerebral glucose metabolism in long-term survivors of childhood acute lymphocytic leukemia. ( 2042943 )
1991
44
Decrease in cerebral metabolic rate of glucose after high-dose methotrexate in childhood acute lymphocytic leukemia. ( 2242171 )
1990
45
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. ( 2323651 )
1990
46
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. ( 2407301 )
1990
47
Improved prognosis for childhood acute lymphocytic leukemia with very high white blood cell count (greater than 100/nl) with rotation of non-cross-resistant drug combinations. ( 2182442 )
1990
48
An unusual t(9;12)(p13;q24) in childhood acute lymphocytic leukemia. ( 2702632 )
1989
49
Induction of tumoricidal activity and alterations of growth by interleukin-2 and manipulation of protein kinase C and cytosolic calcium in childhood acute lymphocytic leukemia cells. ( 2787455 )
1989
50
Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. Case report. ( 6590801 )
1984

Variations for Acute Lymphoblastic Leukemia, Childhood

Copy number variations for Acute Lymphoblastic Leukemia, Childhood from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 250737 9 21967751 21994490 Deletion CDKN2A pediatric acute lymphoblastic leukemia

Expression for Acute Lymphoblastic Leukemia, Childhood

Search GEO for disease gene expression data for Acute Lymphoblastic Leukemia, Childhood.

Pathways for Acute Lymphoblastic Leukemia, Childhood

GO Terms for Acute Lymphoblastic Leukemia, Childhood

Cellular components related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.47 ASNS CDKN2A CDKN2B ETV6 FLT3 GSTM1

Biological processes related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.76 ABCB1 MTHFR TYMS XRCC1
2 response to toxic substance GO:0009636 9.61 ASNS NQO1 TYMS
3 glutathione derivative biosynthetic process GO:1901687 9.49 GSTM1 GSTT1
4 negative regulation of phosphorylation GO:0042326 9.48 CDKN2A CDKN2B
5 hematopoietic stem cell proliferation GO:0071425 9.4 ETV6 RUNX1
6 replicative senescence GO:0090399 9.37 CDKN2A MME
7 tetrahydrofolate metabolic process GO:0046653 9.32 MTHFR TYMS
8 response to folic acid GO:0051593 9.26 MTHFR TYMS
9 methionine metabolic process GO:0006555 9.16 MTHFD1 MTHFR
10 folic acid metabolic process GO:0046655 9.13 MTHFD1 MTHFR SLC19A1
11 tetrahydrofolate interconversion GO:0035999 8.8 MTHFD1 MTHFR TYMS

Molecular functions related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cofactor binding GO:0048037 9.16 ASNS TYMS
2 folic acid binding GO:0005542 8.96 SLC19A1 TYMS
3 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2A CDKN2B

Sources for Acute Lymphoblastic Leukemia, Childhood

3 CDC
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10 dbSNP
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16 ExPASy
18 FMA
27 GO
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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