MCID: ACT103
MIFTS: 37

Acute Lymphoblastic Leukemia, Childhood malady

Immune diseases category

Summaries for Acute Lymphoblastic Leukemia, Childhood

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MalaCards: Acute Lymphoblastic Leukemia, Childhood, also known as childhood acute lymphoblastic leukemia, is related to acute leukemia and myeloid leukemia. An important gene associated with Acute Lymphoblastic Leukemia, Childhood is CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)), and among its related pathways are GPCR Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds estrogen and sodium bisulfite have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and renal/urinary system.

Aliases & Classifications for Acute Lymphoblastic Leukemia, Childhood

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42NIH Rare Diseases, 30LifeMap Discovery™, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

acute lymphoblastic leukemia, childhood 42 30
childhood acute lymphoblastic leukemia 42
lymphoblastic leukemia acute childhood 44


Related Diseases for Acute Lymphoblastic Leukemia, Childhood

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17GeneCards, 18GeneDecks
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Diseases related to Acute Lymphoblastic Leukemia, Childhood via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.3KMT2A, ETV6, CDKN2B, CDKN2C, TAL1
2myeloid leukemia30.6ETV6, CDKN2B, KMT2A
3retinoblastoma30.5MDM2, CDKN2A, CDKN2B, CDKN1B, CDKN2C
4acute lymphocytic leukemia30.5MTAP, ETV6, CDKN2A, CDKN2B, CDKN2C, IKZF1
5lung cancer30.3CDKN2A
6oligodendroglioma30.3CDKN2C, CDKN2B, CDKN2A
7hodgkin's lymphoma30.3MDM2, CDKN2C, KMT2A
8breast cancer30.2MDM2, MTAP, ETV6, CDKN2A, CDKN1B, CDKN2C
9leukemia30.2MDM2, MTAP, ETV6, CDKN2A, CDKN2B, CDKN1B
10childhood leukemia10.8
11central nervous system leukemia10.6
12t-cell leukemia10.6
13testicular leukemia10.5
14testicular disease10.5
15acute myeloid leukemia10.5
16nijmegen breakage syndrome10.5
17hypercalcemia10.4
18central nervous system disease10.4
19nervous system disease10.4
20obesity10.4
21lymphoid leukemia10.2
22childhood oligodendroglioma10.2
23osteonecrosis10.2
24acute t cell leukemia10.2
25meningoencephalitis10.2
26spindle cell carcinoma10.2
27hypoglycemia10.2
28siderosis10.2
29nephrocalcinosis10.2
30adult syndrome10.2
31mucoepidermoid carcinoma10.2
32acinar cell carcinoma10.2
33cranial nerve palsy10.2
34herpes simplex10.2
35lymphoblastic leukemia10.2
36nephroblastoma10.2
37pericardial effusion10.2
38pneumonia10.2
39primitive neuroectodermal tumor10.2
40retinitis10.2
41medulloblastoma10.0CDKN2B
42multiple myeloma10.0CDKN2A
43multiple endocrine neoplasia10.0CDKN1B
44thyroid cancer10.0CDKN1B
45esophageal cancer10.0CDKN2A
46rhabdomyosarcoma10.0MDM2
47biliary tract neoplasm10.0MTAP
48lipoma10.0MDM2
49hyperparathyroidism10.0CDKN1B
50mycosis fungoides10.0CDKN2B

Graphical network of the top 20 diseases related to Acute Lymphoblastic Leukemia, Childhood:



Diseases related to acute lymphoblastic leukemia, childhood

Clinical Features for Acute Lymphoblastic Leukemia, Childhood

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Drugs & Therapeutics for Acute Lymphoblastic Leukemia, Childhood

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Lymphoblastic Leukemia, Childhood

Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Acute Lymphoblastic Leukemia, Childhood:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Acute Lymphoblastic Leukemia, Childhood:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Acute Lymphoblastic Leukemia, Childhood

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Anatomical Context for Acute Lymphoblastic Leukemia, Childhood

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32MalaCards
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MalaCards organs/tissues related to Acute Lymphoblastic Leukemia, Childhood:

32
Bone

Animal Models for Acute Lymphoblastic Leukemia, Childhood or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Lymphoblastic Leukemia, Childhood:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.3TAL1
2MP:000536710.3KMT2A
3MP:00053809.5KMT2A, INS
4MP:00036319.5KMT2A, INS
5MP:00053889.0CDKN1B, CDKN2C, IKZF1, CEBPE
6MP:00053799.0ETV6, CDKN2A, CDKN2B, CDKN1B, CDKN2C
7MP:00053908.6CEBPE, KMT2A, TAL1, ARID5B
8MP:00053898.3ARID5B, CDKN2A, CDKN2B, CDKN1B, CDKN2C, KMT2A
9MP:00053697.9MDM2, ARID5B, CDKN2A, INS, LEP
10MP:00030127.9MDM2, ETV6, CDKN2A, CDKN2B, CDKN1B, INS
11MP:00053707.7MDM2, MTAP, CDKN2A, CDKN1B, INS, IKZF1
12MP:00053767.4ARID5B, ETV6, CDKN2C, INS, TAL1, LEP
13MP:00053857.3MDM2, MTAP, ETV6, CDKN1B, CDKN2C, INS
14MP:00020067.3MDM2, ETV6, CDKN2A, CDKN2B, CDKN1B, CDKN2C
15MP:00053867.0MDM2, ARID5B, CDKN2A, CDKN1B, CDKN2C, INS
16MP:00053816.6MDM2, ARID5B, ETV6, CDKN2A, CDKN1B, INS
17MP:00107716.6MDM2, ETV6, CDKN2A, CDKN2B, CDKN1B, CDKN2C
18MP:00053786.0MDM2, ARID5B, ETV6, CDKN2A, CDKN1B, CDKN2C
19MP:00053975.4CDKN2B, CDKN2A, ETV6, ARID5B, MDM2, CDKN1B
20MP:00053845.3MDM2, ARID5B, ETV6, CDKN2A, CDKN2B, CDKN1B
21MP:00053875.1CEBPE, MDM2, ARID5B, MTAP, ETV6, CDKN2A
22MP:00107685.1CDKN2B, CDKN2A, ETV6, MTAP, ARID5B, MDM2

Publications for Acute Lymphoblastic Leukemia, Childhood

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Genetic Variations for Acute Lymphoblastic Leukemia, Childhood

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Expression for genes affiliated with Acute Lymphoblastic Leukemia, Childhood

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Lymphoblastic Leukemia, Childhood

Search GEO for disease gene expression data for Acute Lymphoblastic Leukemia, Childhood.

Pathways for genes affiliated with Acute Lymphoblastic Leukemia, Childhood

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51QIAGEN, 52R&D Systems, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 4Cell Signaling Technology
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Pathways related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CDKN2B
2
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10.2CDKN1B
39.8MDM2, CDKN2A
49.8MDM2, CDKN2A
59.8CDKN1B, MDM2
6
Cell cycle Cell cycle (generic schema)
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9.6CDKN1B, CDKN2B, CDKN2A
7
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9.5MDM2, CDKN2A, CDKN1B
89.5CDKN1B, CDKN2A, MDM2
9
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9.5CDKN1B, CDKN2A, MDM2
10
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9.5CDKN1B, CDKN2A, MDM2
11
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9.4CDKN2C, CDKN1B, CDKN2B, CDKN2A
129.3MDM2, CDKN2A, CDKN2B, CDKN1B
139.3MDM2, CDKN2A, CDKN2B, CDKN1B
14
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9.3CDKN2C, CDKN1B, CDKN2A, MDM2
15
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9.3CDKN2C, CDKN1B, CDKN2A, MDM2
16
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9.0MDM2, CDKN2A, CDKN2B, CDKN1B, CDKN2C
17
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8.6MDM2, CDKN2A, CDKN2B, CDKN1B, CDKN2C, INS
188.6MDM2, CDKN2A, CDKN1B, INS, KMT2A
198.0CEBPE, KMT2A, CDKN2C, CDKN1B, ETV6, MDM2

Compounds for genes affiliated with Acute Lymphoblastic Leukemia, Childhood

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4KMT2A
2sodium bisulfite4410.2CDKN2B, CDKN2A
3fatty acid4410.1CDKN2A, CDKN1B
4exenatide44 1111.1LEP, INS
55-methylthioadenosine4410.1CDKN2B, CDKN2A, MTAP
67,12-dimethylbenz(a)anthracene4410.1MDM2, CDKN2A
7sibutramine44 1111.0LEP, INS
8pramlintide44 1111.0LEP, INS
9beta-hydroxybutyrate4410.0LEP, INS
10cytarabine44 49 1112.0CDKN2A, CDKN2B, CDKN1B
11acipimox44 2811.0LEP, INS
12flavopiridol44 1110.9CDKN1B, CDKN2A, MDM2
13nucleoside449.9MDM2, MTAP, CDKN1B
14intralipid449.8INS, LEP
155-methylcytosine44 2410.8CDKN2A, CDKN2B
16nash449.8INS, LEP
17camptothecin44 59 1111.8MDM2, CDKN2A, CDKN1B
18adenine44 11 2411.8MTAP, CDKN2A, LEP
19mg 13244 5910.7CDKN1B, CDKN2A, MDM2
20telmisartan44 28 1111.7INS, LEP
21troglitazone44 28 59 1112.7LEP, INS, CDKN1B
22vincristine44 49 1111.7MDM2, CDKN2A, KMT2A
23p003449.6MDM2, CDKN2B, CDKN1B, LEP
24pd 98,059449.6LEP, CDKN1B, CDKN2B, MDM2
255-aza-2deoxycytidine449.5MDM2, CDKN2A, CDKN2B, KMT2A
26paraffin449.5MDM2, CDKN2A, CDKN1B, LEP
27p00001449.4MDM2, CDKN2A, CDKN1B, KMT2A
28etoposide44 49 59 1112.4MDM2, CDKN1B, TAL1, KMT2A
29rapamycin449.4MDM2, CDKN1B, INS, LEP
30ly294002449.4MDM2, CDKN1B, INS, LEP
31wortmannin449.4MDM2, CDKN1B, INS, LEP
32doxorubicin44 49 1111.4MDM2, CDKN2A, CDKN1B, KMT2A
33actinomycin d449.4KMT2A, CDKN1B, CDKN2A, MDM2
34cisplatin44 49 59 1112.3MDM2, CDKN2A, CDKN1B, LEP
35genistein44 28 59 2 11 2414.3MDM2, CDKN2A, CDKN1B, KMT2A
36imatinib44 49 1111.3CDKN1B, ETV6, MDM2
37testosterone44 59 11 2412.1MDM2, CDKN2A, CDKN1B, INS, LEP
38oligonucleotide449.1KMT2A, TAL1, CDKN1B, CDKN2A, MDM2
39agar449.0MDM2, MTAP, ETV6, CDKN2A, CDKN1B
40progesterone44 59 28 11 2413.0MDM2, CDKN2A, CDKN1B, IKZF1, LEP
41dexamethasone44 49 28 1112.0MDM2, CDKN2A, CDKN1B, INS, IKZF1
42alanine448.9MDM2, CDKN2A, CDKN1B, INS, IKZF1
43leucine448.8KMT2A, IKZF1, CDKN1B, CDKN2A
44vegf448.7MDM2, ETV6, CDKN2A, CDKN1B, TAL1, LEP
45threonine448.7MDM2, MTAP, CDKN2A, CDKN2B, CDKN1B, CDKN2C
46arginine448.6MDM2, CDKN2A, CDKN1B, INS, LEP, KMT2A
47retinoic acid44 249.6ETV6, CDKN2A, CDKN2B, CDKN1B, TAL1, KMT2A
48methotrexate44 49 1110.2LEP, CDKN1B, CDKN2B, CDKN2A, MTAP, ARID5B
49atp44 289.2MTAP, CDKN2A, CDKN1B, IKZF1, KMT2A
50serine447.9MDM2, CDKN2A, CDKN2B, CDKN1B, CDKN2C, INS

GO Terms for genes affiliated with Acute Lymphoblastic Leukemia, Childhood

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16Gene Ontology
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Cellular components related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056345.5CEBPE, ARID5B, MTAP, ETV6, CDKN2A, CDKN2B

Biological processes related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1megakaryocyte differentiationGO:03021910.2TAL1, CDKN2B
2cellular response to antibioticGO:07123610.0CDKN1B, MDM2
3positive regulation of insulin receptor signaling pathwayGO:0466289.9INS, LEP
4regulation of cyclin-dependent protein serine/threonine kinase activityGO:0000799.9CDKN2C, CDKN1B, CDKN2B
5negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.9CDKN2A, CDKN1B
6negative regulation of cell growthGO:0303089.8CDKN2C, CDKN1B, CDKN2A
7protein destabilizationGO:0316489.7MDM2, CDKN2A
8embryonic hemopoiesisGO:0351629.7KMT2A, TAL1
9negative regulation of phosphorylationGO:0423269.7CDKN2C, CDKN1B, CDKN2B, CDKN2A
10cell cycle arrestGO:0070509.7CDKN2A, CDKN2B, CDKN1B, CDKN2C
11mitotic cell cycleGO:0002789.5CDKN2A, CDKN2B, CDKN1B, CDKN2C
12adipose tissue developmentGO:0606129.3LEP, ARID5B
13positive regulation of cell proliferationGO:0082849.1MDM2, CDKN1B, INS, LEP
14negative regulation of cell proliferationGO:0082859.1CDKN2A, CDKN2B, CDKN1B, CDKN2C, KMT2A
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.8CDKN2A, CDKN2B, IKZF1, TAL1, KMT2A
16negative regulation of transcription, DNA-dependentGO:0458928.4CDKN1B, CDKN2A, ARID5B, MDM2

Molecular functions related to Acute Lymphoblastic Leukemia, Childhood according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.4CDKN2C, CDKN1B, CDKN2B, CDKN2A
2transcription regulatory region DNA bindingGO:0442128.9KMT2A, TAL1, ARID5B
3sequence-specific DNA binding transcription factor activityGO:0037007.8ETV6, IKZF1, TAL1, KMT2A, CEBPE
4protein bindingGO:0055156.3MDM2, ARID5B, ETV6, CDKN2A, CDKN2B, CDKN1B

Products for genes affiliated with Acute Lymphoblastic Leukemia, Childhood

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Sources for Acute Lymphoblastic Leukemia, Childhood

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3CDC
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14FMA
22GTR
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24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
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34MeSH
35MESH via Orphanet
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39NCIt
40NDF-RT
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44Novoseek
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47OMIM via Orphanet
50PubMed
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