MCID: ACT074
MIFTS: 56

Acute Lymphocytic Leukemia malady

Categories: Cancer diseases, Immune diseases, Rare diseases, Genetic diseases, Blood diseases

Aliases & Classifications for Acute Lymphocytic Leukemia

Aliases & Descriptions for Acute Lymphocytic Leukemia:

Name: Acute Lymphocytic Leukemia 38 12 41 14 69
Acute Lymphoblastic Leukemia 12 14
Precursor Cell Lymphoblastic Leukemia Lymphoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9952
ICD10 33 C91.0 C91.00
ICD9CM 35 204.0
NCIt 47 C3167
UMLS 69 C0023449

Summaries for Acute Lymphocytic Leukemia

MedlinePlus : 41 leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards based summary : Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to adult acute lymphocytic leukemia and pyomyositis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Acute Lymphocytic Leukemia is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Pathways in cancer and Pancreatic cancer. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

Related Diseases for Acute Lymphocytic Leukemia

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 3 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 2 Adult Acute Lymphocytic Leukemia
Chronic Lymphocytic Leukemia

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
id Related Disease Score Top Affiliating Genes
1 adult acute lymphocytic leukemia 31.9 ANKS1B ASNS BCR CDKN2A CDKN2B CSF3
2 pyomyositis 29.8 CDKN2A NR3C1 TP53
3 b-cell adult acute lymphocytic leukemia 12.0
4 t-cell adult acute lymphocytic leukemia 12.0
5 t-cell childhood acute lymphocytic leukemia 12.0
6 leukemia, acute lymphoblastic 11.7
7 acute lymphoblastic leukemia, childhood 11.7
8 leukemia 11.5
9 acute leukemia 11.3
10 childhood leukemia 11.3
11 leukemia, acute lymphoblastic 3 11.1
12 precursor t-cell acute lymphoblastic leukemia 11.1
13 lymphoblastic leukemia 11.0
14 ataxia-telangiectasia 11.0
15 alcohol abuse 10.3 CDKN2B MME TYMS
16 prostate cancer 10.3
17 lymphoma, small cleaved-cell, diffuse 10.3 CDKN2B MME NOTCH1 TAL1
18 comt-related pain sensitivity alteration 10.3 BCR ETV6 RUNX1
19 congenital sucrase-isomaltase deficiency without sucrose intolerance 10.3 NOTCH1 TP53
20 lymphomatoid granulomatosis 10.3 BCR ETV6 RUNX1
21 extranodal nasal nk/t cell lymphoma 10.3 CDKN2A CDKN2B CSF3
22 clear cell adenofibroma 10.3 CDKN2A TP53
23 pharc syndrome 10.3 CSF3 MTHFR TYMS
24 ampulla of vater neoplasm 10.3 CDKN2A CDKN2B TP53
25 lacrimal gland adenoid cystic carcinoma 10.3 CDKN2A TP53
26 intracranial cysts 10.3 MTHFR TYMS
27 brain stem medulloblastoma 10.2 CDKN2A NOTCH1 TP53
28 uterine disease 10.2 CDKN2A CDKN2B TP53
29 posterior myocardial infarction 10.2 CDKN2A MME
30 childhood brain stem glioma 10.2 MME PAX5 TP53
31 interstitial lung disease 10.2 CDKN2A CDKN2B TP53
32 pericardium leiomyoma 10.2 CDKN2A TP53
33 advanced sleep phase syndrome 10.2 CDKN2A MTHFR TP53
34 actinobacillosis 10.2 BCR CSF3 ETV6 RUNX1
35 traumatic brain injury 10.2 CDKN2A NOTCH1 TP53
36 bifid uvula 10.2 BCR CDKN2A NOTCH1 TAL1 TLX3
37 lattice corneal dystrophy 10.2 CDKN2A CDKN2B TP53
38 peroxisome biogenesis disorder 7a 10.2 BCR CSF3 ETV6 RUNX1
39 ectodermal dysplasia 10.2 CDKN2A MME PAX5 TP53
40 mixed astrocytoma-ependymoma-oligodendroglioma 10.2 ETV6 MTHFR RUNX1 TP53
41 non-distal monosomy 10q 10.2 CDKN2A ETV6 MTHFR TP53
42 bladder disease 10.1 CDKN2A MME PAX5 TP53
43 spondylarthropathy 10.1 CDKN2A TP53
44 milker's nodule 10.1 BCR CSF3 ETV6 RUNX1
45 lymphoma 10.0
46 pulmonary fibrosis, idiopathic 10.0 BCR CDKN2B CSF3 MME PAX5 TP53
47 thoracic outlet syndrome 10.0 CDKN2A CDKN2B TP53
48 hemophagocytic lymphohistiocytosis 10.0 BCR CDKN2B CSF3 ETV6 NOTCH1 PAX5
49 hematopoietic stem cell transplantation 10.0
50 hyperglycemia 9.9

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Acute Lymphocytic Leukemia

UMLS symptoms related to Acute Lymphocytic Leukemia:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.36 ANKS1B ASNS BCR CDKN2A ETV6 MTHFR
2 homeostasis/metabolism MP:0005376 10.35 BCR CDKN2A CDKN2B ETV6 MME MTHFR
3 hematopoietic system MP:0005397 10.34 ASNS BCR CDKN2A CDKN2B CSF3 ETV6
4 immune system MP:0005387 10.27 BCR CDKN2A CDKN2B CSF3 ETV6 MME
5 integument MP:0010771 10.21 CDKN2A CDKN2B CSF3 ETV6 MME MTHFR
6 mortality/aging MP:0010768 10.21 BCR CDKN2A CDKN2B ETV6 MTHFR NOTCH1
7 digestive/alimentary MP:0005381 10.07 BCR CDKN2A ETV6 NOTCH1 NR3C1 TLX3
8 nervous system MP:0003631 10.07 ANKS1B ASNS BCR CDKN2A MTHFR NOTCH1
9 liver/biliary system MP:0005370 9.95 BCR CDKN2A MME NOTCH1 NR3C1 RUNX1
10 neoplasm MP:0002006 9.92 NOTCH1 PAX5 RUNX1 TLX3 TP53 CDKN2A
11 no phenotypic analysis MP:0003012 9.7 CDKN2A CDKN2B ETV6 MTHFR NR3C1 RUNX1
12 renal/urinary system MP:0005367 9.5 BCR CDKN2B CSF3 NOTCH1 NR3C1 TAL1
13 skeleton MP:0005390 9.28 ANKS1B CDKN2A MTHFR NOTCH1 NR3C1 PAX5

Drugs & Therapeutics for Acute Lymphocytic Leukemia

FDA approved drugs:

(show all 7)
id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Arranon 17 46 NELARABINE GlaxoSmithKline Approved October 2005
2
Blincyto 17 46 BLINATUMOMAB Amgen Approved December 2014
3
Clolar 17 46 CLOFARABINE Genzyme Approved December, 2004
4
Erwinaze 17 46 asparaginase Erwinia chrysanthemi Eusa Pharma Approved November of 2011
5
Iclusig 17 46 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals Approved December 2012
6
Marqibo 17 46 VINCRISTINE SULFATE Talon Therapeutics Approved August 2012
7
Sprycel 17 46 DASATINIB Bristol-Myers Squibb Approved June 2006

Drugs for Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 622)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
3
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 147-94-4 6253
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
5
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
6
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
7
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
11
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
12
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
13
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
14
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
15
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
16
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
17
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
18
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
19
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
20
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
21
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
22
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
23
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
25
Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
26
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
28
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
29
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
30
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
31
Oprelvekin Approved, Investigational Phase 4 145941-26-0
32
Menthol Approved Phase 4 2216-51-5 16666
33
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
34
Blinatumomab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 853426-35-4
35
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
36
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
37
Nicotine Approved Phase 4 54-11-5 942 89594
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
39
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
40
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
41
Butyric Acid Experimental Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
42 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1
43 Adjuvants, Immunologic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
44 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
47 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
48 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
50 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1730)
id Name Status NCT ID Phase
1 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4
2 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4
3 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4
4 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4
5 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4
6 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4
7 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
8 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4
9 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4
10 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4
11 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4
12 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4
13 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4
14 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4
15 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4
16 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4
17 Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia Completed NCT01457040 Phase 4
18 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
19 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4
20 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4
21 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4
22 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4
23 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4
24 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4
25 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4
26 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
27 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4
28 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4
29 Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS Recruiting NCT01540812 Phase 4
30 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4
31 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4
32 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4
33 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4
34 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Recruiting NCT01873807 Phase 4
35 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
36 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
37 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4
38 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Recruiting NCT02290132 Phase 4
39 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4
40 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Active, not recruiting NCT01200355 Phase 4
41 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4
42 Expanded Access Protocol of Blinatumomab in Pediatric and Adolescent Subjects With Relapsed and/or Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) Available NCT02187354 Phase 4
43 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Not yet recruiting NCT02690922 Phase 4
44 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
45 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
46 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4
47 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4
48 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3
49 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3
50 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

39
Bone, Bone Marrow, T Cells, Myeloid, B Cells, Skin, Testes

Publications for Acute Lymphocytic Leukemia

Articles related to Acute Lymphocytic Leukemia:

(show top 50) (show all 605)
id Title Authors Year
1
Allogeneic bone marrow transplantation for therapy-related acute lymphocytic leukemia after autologous hematopoietic stem cell transplantation for multiple myeloma. ( 27473192 )
2016
2
Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors. ( 27094799 )
2016
3
Catheter-related bloodstream infection due to Gordonia sputi in a patient with acute lymphocytic leukemia: a Case Report. ( 26902218 )
2016
4
Palifermin and Chlorhexidine Mouthwashes in Prevention of Chemotherapy-Induced Mucositis in Children with Acute Lymphocytic Leukemia: a Randomized Controlled Trial. ( 27942550 )
2016
5
Immunization practices in acute lymphocytic leukemia and post-hematopoietic stem cell transplant in Canadian Pediatric Hematology/Oncology centers. ( 26962702 )
2016
6
Recurrence of acute lymphocytic leukemia as spinal epidural mass. ( 26778825 )
2016
7
B Cell Acute Lymphocytic Leukemia Presenting as a Bile Duct Stricture Diagnosed With Cholangioscopy. ( 27807569 )
2016
8
Secondary glioma following acute lymphocytic leukemia: therapeutic implications. ( 27159974 )
2016
9
Multiple unusual lung etiologies in a child with acute lymphocytic leukemia. ( 27616461 )
2016
10
Campylobacter jejuni Bacteremia in a Patient With Acute Lymphocytic Leukemia. ( 27621914 )
2016
11
Expression of CD56 is a risk factor for acute lymphocytic leukemia with central nervous system involvement in adults. ( 27734763 )
2016
12
Disseminated Mycobacterium abscessus Complex Infection Manifesting as Multiple Areas of Lymphadenitis and Skin Abscess in the Preclinical Stage of Acute Lymphocytic Leukemia. ( 27374685 )
2016
13
Myelodysplastic Syndrome and Acute Lymphocytic Leukemia in Common Variable Immunodeficiency (CVID). ( 26993985 )
2016
14
Extramedullary Involvement of the Sigmoid Colon with Acute Lymphocytic Leukemia. ( 27189376 )
2016
15
Potent anti-leukemia activities of chimeric antigen receptor modified T cells against CD19 in Chinese patients with relapsed/refractory acute lymphocytic leukemia. ( 28039267 )
2016
16
Recent advances and novel treatment paradigms in acute lymphocytic leukemia. ( 27695616 )
2016
17
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )
2016
18
Blinatumomab: A New Treatment for Adults With Relapsed Acute Lymphocytic Leukemia. ( 26991709 )
2016
19
BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients. ( 27123097 )
2016
20
Treating adults with acute lymphocytic leukemia: new pharmacotherapy options. ( 27759440 )
2016
21
Acute lymphocytic leukemia presenting as a single brain mass. ( 27430416 )
2016
22
Novel Approaches for the Interim Management of Relapsed/Refractory Acute Lymphocytic Leukemia: Introduction. ( 27007406 )
2016
23
Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia. ( 27987364 )
2016
24
Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia. ( 27599414 )
2016
25
Acute lymphocytic leukemia mimicking spondyloarthritis in an adolescent: A case report and review of the literature. ( 26893708 )
2016
26
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. ( 27301866 )
2016
27
Role of peripheral blood minimum residual disease at day 8 of induction therapy in high-risk pediatric patients with acute lymphocytic leukemia. ( 27526794 )
2016
28
Subcutaneous adipose tissue plays a beneficial effect on subclinical atherosclerosis in young survivors of acute lymphocytic leukemia. ( 26316772 )
2015
29
Comparative study of quality of life of adult survivors of childhood acute lymphocytic leukemia and Wilms' tumor. ( 26537509 )
2015
30
Mechanistic Study of the Phytocompound, 2- I^ -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches. ( 26557148 )
2015
31
Acute Lymphocytic Leukemia with Bilateral Renal Masses Masquerading as Nephroblastomatosis. ( 26613060 )
2015
32
Prognostic Significance of Lymphoid Enhancer-Binding Factor-1 Expression in Egyptian Adult B-Acute Lymphocytic Leukemia Patients. ( 25805670 )
2015
33
Incidental detection of congenital Robertsonian translocation at diagnosis of Philadelphia chromosome-positive acute lymphocytic leukemia. ( 26062669 )
2015
34
Tetramethylpyrazine inhibits the proliferation of acute lymphocytic leukemia cell lines via decrease in GSK-3I^. ( 25812605 )
2015
35
L-asparaginase and venous thromboembolism in acute lymphocytic leukemia. ( 26274336 )
2015
36
Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia. ( 26661660 )
2015
37
Myeloid Antigen-positive T Cell Acute Lymphocytic Leukemia with t(14;18) and Trisomy 10: Report of a Case and Literature Review. ( 26265522 )
2015
38
Acute Lymphocytic Leukemia in Adults. Pathologic Features and Prognosis. ( 26076558 )
2015
39
A rare case of chemotherapy induced reversible cerebral vasoconstriction syndrome in a patient of acute lymphocytic leukemia. ( 26881572 )
2015
40
Successful Pregnancy and Delivery After Radiation With Ovarian Shielding for Acute Lymphocytic Leukemia Before Menarche. ( 25739028 )
2015
41
The clinical potential of inotuzumab ozogamicin in relapsed and refractory acute lymphocytic leukemia. ( 26425338 )
2015
42
Medical history, lifestyle, family history, and occupational risk factors for adult acute lymphocytic leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. ( 25174033 )
2014
43
Erdheim-Chester disease with rare radiological features in a 14-year old girl with pre-B Acute Lymphocytic Leukemia and Diabetes Mellitus. ( 25426240 )
2014
44
The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia-a systematic review. ( 24997618 )
2014
45
Impact of chemotherapy-related hyperglycemia on prognosis of child acute lymphocytic leukemia. ( 25374219 )
2014
46
New antibodies for acute lymphocytic leukemia. ( 25356581 )
2014
47
Agents for refractory/relapsed acute lymphocytic leukemia in adults. ( 25268091 )
2014
48
Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker. ( 25293656 )
2014
49
Novel treatments in acute lymphocytic leukemia. ( 25003350 )
2014
50
Acute lymphocytic leukemia with superimposed invasive aspergillosis and pneumopericardium successfully treated with voriconazole. ( 24982579 )
2014

Variations for Acute Lymphocytic Leukemia

ClinVar genetic disease variations for Acute Lymphocytic Leukemia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ACTB NP_001092.1(ACTB): p.Val209Leu protein only Pathogenic

Expression for Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for Acute Lymphocytic Leukemia

Pathways related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.32 BCR CDKN2A CDKN2B RUNX1 TP53
2
Show member pathways
11.6 BCR CDKN2A RUNX1 TP53
3 11.28 ETV6 PAX5 RUNX1 TLX3 TP53
4 11.11 CSF3 NOTCH1 RUNX1
5 10.64 CDKN2A CDKN2B TP53

GO Terms for Acute Lymphocytic Leukemia

Cellular components related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.5 ANKS1B ASNS BCR CDKN2A CDKN2B ETV6

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.85 CDKN2A ETV6 NOTCH1 NR3C1 PAX5 RUNX1
2 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.8 ETV6 NOTCH1 NR3C1 PAX5 TAL1 TP53
3 definitive hemopoiesis GO:0060216 9.51 BCR TAL1
4 hematopoietic stem cell proliferation GO:0071425 9.48 ETV6 RUNX1
5 tetrahydrofolate interconversion GO:0035999 9.46 MTHFR TYMS
6 tetrahydrofolate metabolic process GO:0046653 9.43 MTHFR TYMS
7 somatic stem cell division GO:0048103 9.4 CDKN2A NOTCH1
8 response to folic acid GO:0051593 9.37 MTHFR TYMS
9 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.32 CDKN2A CDKN2B CSF3 ETV6 NOTCH1 NR3C1
10 megakaryocyte differentiation GO:0030219 9.26 CDKN2B TAL1
11 replicative senescence GO:0090399 9.13 CDKN2A MME TP53
12 transcription, DNA-templated GO:0006351 10.15 CDKN2A ETV6 NOTCH1 NR3C1 PAX5 RUNX1

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.7 ETV6 NOTCH1 NR3C1 PAX5 RUNX1 TAL1
2 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.56 ETV6 TAL1 TAL2 TP53
3 core promoter binding GO:0001047 9.5 NOTCH1 NR3C1 RUNX1
4 cofactor binding GO:0048037 9.43 ASNS TYMS
5 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.4 CDKN2A CDKN2B
6 enzyme binding GO:0019899 9.35 BCR CSF3 NOTCH1 TAL1 TP53
7 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.02 ETV6 RUNX1 TAL1 TAL2 TP53
8 DNA binding GO:0003677 10.02 CDKN2A ETV6 NR3C1 PAX5 RUNX1 TAL1

Sources for Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
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31 HMDB
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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