ALL
MCID: ACT074
MIFTS: 77

Acute Lymphocytic Leukemia (ALL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Acute Lymphocytic Leukemia

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to acute leukemia and leukemia. An important gene associated with Acute Lymphocytic Leukemia is BCR (breakpoint cluster region), and among its related pathways are Lymphocyte Signaling and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds dihydrofolate and b vitamins have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are mortality/aging and hematopoietic system.

Wikipedia:63 Acute lymphoblastic leukemia (ALL) is a form of leukemia, or cancer of the white blood cells... more...

Description from OMIM:46 613065,613067,247640

Aliases & Classifications for Acute Lymphocytic Leukemia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 9diseasecard, 46OMIM, 44Novoseek, 39NCIt, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acute lymphocytic leukemia:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute lymphocytic leukemia 8 42 48 33 30 60
acute lymphoblastic leukemia 8 42 48
leukemia, acute lymphoblastic 9 46
all 42 48
leukemia, acute lymphoblastic, susceptibility to 9
acute lymphoblastic leukemia/lymphoma 48
lymphoblastic leukemia acute 44
leukemia, acute lymphocytic 46


External Ids:

Disease Ontology8 DOID:9952
NCIt39 C3167
ICD9CM27 204.0
ICD10 via Orphanet26 C91.0
ICD1025 C91.0

Related Diseases for Acute Lymphocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1419)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.1NUP98, TAL1, PAX5, BCR, MTHFR, CDKN2B
2leukemia32.1TAL1, MTHFR, MTR, ANKS1B, TYMS, NUP98
3adult acute lymphocytic leukemia31.6SHMT1, TYMS, CDKN2B
4myeloid leukemia30.8CDKN2B, NUP98, BCR
5non-hodgkin lymphoma30.7PAX5, BCR, CDKN2B, MTR, IKZF1, TAL1
6acute lymphoblastic leukemia, childhood30.7BCR, MME, IKZF1, CDKN2B, MTHFR, TYMS
7burkitt's lymphoma30.6MME, PAX5, BCR
8retinoblastoma30.5TYMS, CDKN2B, BCR, CDKN1C
9rheumatoid arthritis30.5MME, MTHFR
10myeloma30.4CDKN2B, PAX5, BCR
11chronic myeloid leukemia30.4BCR, TAL1, IKZF1, CDKN1C, CDKN2B, NUP98
12precursor b-cell acute lymphoblastic leukemia30.3MME, CDKN2B, PAX5, BCR
13precursor t-cell acute lymphoblastic leukemia30.3TYMS, NUP98, BCR, PAX5, IKZF1, CDKN2B
14prostate cancer30.3MME, BCR, CDKN2B, CDX2
15hepatocellular carcinoma30.2CDKN2B, CDX2, MME, BCR, CDKN1C
16melanoma30.1CDKN2B, MME, CDX2
17lung cancer30.1TYMS
18esophagitis30.1CDX2, CDX1
19osteosarcoma30.1TYMS
20adenoma30.1CDKN1C, CDX2, CDX1, MTR, MTHFR
21breast cancer30.1SHMT1, CDKN1C, CDX2, MTHFR, MTR, MME
22glioblastoma multiforme30.1CDKN1C, CDKN2B
23down syndrome30.1MTR, MTHFR
24meningioma30.1CDKN2B
25adenocarcinoma30.1MME, CDX2, CDX1, CDKN1C, TYMS
26pancreatic cancer30.1CDKN1C, CDX2, TYMS
27colorectal cancer29.9MTHFR, SHMT1, TYMS, CDX2, MTR, CDKN1C
28colon cancer29.8MTHFR, MTR, CDX1, CDKN2B, CDX2, TYMS
29ovarian cancer29.8TYMS, MME
30spina bifida29.8MTHFR, MTR
31malignant mesothelioma29.8TYMS, CDKN2B
32migraine29.7MTHFR
33cholangiocarcinoma29.6CDX2, MME
34gallbladder cancer29.6TYMS, CDX2
35bladder carcinoma29.4TYMS
36hematologic cancer29.4PAX5, BCR, CDKN1C, CDKN2B, NUP98, IKZF1
37childhood leukemia11.0
38acute t cell leukemia10.8
39t-cell leukemia10.8
40chronic lymphocytic leukemia10.6
41hemophagocytic lymphohistiocytosis10.6
42acute myeloid leukemia10.5
43acute pancreatitis10.5
44fusariosis10.5
45obesity10.5
46pancreatitis10.5
47central nervous system leukemia10.5
48noonan syndrome10.5
49hyperphosphatemia10.5
50arthritis10.5

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to acute lymphocytic leukemia

Clinical Features for Acute Lymphocytic Leukemia

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

613065,613067,247640

Drugs & Therapeutics for Acute Lymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Lymphocytic Leukemia

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Search CenterWatch for Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Lymphocytic Leukemia

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Anatomical Context for Acute Lymphocytic Leukemia

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

32
Bone, Bone marrow, T cells, B cells, Skin, Testes, Myeloid, Liver, Monocytes, Thyroid, Breast, Kidney, Brain, Prostate, Spleen, Whole blood, Endothelial, Pineal

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Acute Lymphocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.8BCR, MTHFR, MTR, SHMT1, NUP98, CDKN2B
2MP:000539710.7NUP98, CDKN2B, CDX1, CDKN1C, IKZF1, TAL2
3MP:000537810.7CDKN1C, CDX2, NUP98, MTHFR, HOXD4, IKZF1
4MP:000538710.6CDKN1C, CDKN2B, NUP98, GIMAP4, IKZF1, TAL1
5MP:000538410.6CDKN2B, CDX2, CDKN1C, IKZF1, TAL1, TCF3
6MP:000537610.5CDKN2B, SHMT1, MTR, MTHFR, CDX2, CDKN1C
7MP:000539010.2CDX1, CDX2, CDKN1C, HOXD4, TAL1, PAX5

Publications for Acute Lymphocytic Leukemia

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Sources:
50PubMed
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Articles related to Acute Lymphocytic Leukemia:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Biology and treatment of acute lymphocytic leukemia in adolescents and young adults. (23714524)
2013
2
Interaction Between Myelomonocytic and Lymphoid Cells in a Patient with Acute MyeloMonocytic Leukemia and Chronic Lymphocytic Leukemia. (23987820)
2013
3
Superiority of preemptive donor lymphocyte infusion based on minimal residual disease in acute leukemia patients after allogeneic hematopoietic stem cell transplantation. (24372162)
2013
4
Cranial radiotherapy predisposes to abdominal adiposity in survivors of childhood acute lymphocytic leukemia. (23433104)
2013
5
Renal abscess involving mucormycosis by immunohistochemical detection in a patient with acute lymphocytic leukemia: a case report and literature review. (23883851)
2013
6
Intractable diffuse alopecia caused by multifactorial side-effects in treatment of acute lymphocytic leukemia: connection to iatrogenic failure of estrogen secretion. (22211668)
2013
7
Outcome of donor lymphocyte infusion after T cell-depleted allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndromes. (23266740)
2013
8
Ovarian reserve in women treated for acute lymphocytic leukemia or acute myeloid leukemia with chemotherapy, but not stem cell transplantation. (23050166)
2012
9
Leser-TrAclat sign presenting in a patient with recurrent pre-B-cell acute lymphocytic leukemia. (22439308)
2012
10
Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906. (21360654)
2011
11
B cell acute lymphocytic leukemia in pregnancy. (20717686)
2011
12
A phase I/II study of chemotherapy followed by donor lymphocyte infusion plus interleukin-2 for relapsed acute leukemia after allogeneic hematopoietic cell transplantation. (21232624)
2011
13
The Effect of self-care on the lives of children suffering from acute lymphocytic leukemia. (22039382)
2011
14
Decreased hormone content of immune cells in children during acute lymphocytic leukemia (ALL) - effect of treatment. (21450554)
2011
15
Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (21518475)
2011
16
Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting. (19718057)
2010
17
Executive function, coping, and behavior in survivors of childhood acute lymphocytic leukemia. (18667478)
2009
18
Antioxidant status in pediatric acute lymphocytic leukemia (ALL) and solid tumors: the impact of oxidative stress. (18623225)
2008
19
Leukemic infiltration of the breast in acute lymphocytic leukemia (ALL). (18616877)
2008
20
Ribosome display and selection of human anti-cD22 scFvs derived from an acute lymphocytic leukemia patient. (18225987)
2008
21
Pyomyositis as the presenting feature of acute lymphocytic leukemia. (18258997)
2008
22
Philadelphia chromosome positive acute lymphocytic leukemia: a new era of challenges. (18024662)
2007
23
Treatment of acute lymphocytic leukemia using zinc adjuvant with chemotherapy and radiation--a case history and hypothesis. (15823699)
2005
24
West Nile virus infection in a teenage boy with acute lymphocytic leukemia in remission. (16344671)
2005
25
Secondary malignant neoplasms of the bladder after cyclophosphamide treatment for childhood acute lymphocytic leukemia. (14752871)
2004
26
Expression of CD58 in normal, regenerating and leukemic bone marrow B cells: implications for the detection of minimal residual disease in acute lymphocytic leukemia. (14607753)
2003
27
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. (12586619)
2003
28
Splenic artery embolization as emergency treatment of splenic rupture in a child with T-cell acute lymphocytic leukemia having t(8;14) translocation. (14515402)
2003
29
DNA methylation patterns at relapse in adult acute lymphocytic leukemia. (12060634)
2002
30
Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes. Correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia. (11726315)
2001
31
Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults. (11253611)
2001
32
Prevalence of myeloperoxidase gene expression in infant acute lymphocytic leukemia. (9802341)
1998
33
Apoptosis and acute lymphocytic leukemia in children. (9382453)
1997
34
Candida abscess of the thyroid in a patient with acute lymphocytic leukemia. (9262492)
1997
35
A low rate of loss of heterozygosity is found at many different loci in childhood B-lineage acute lymphocytic leukemia. (8751467)
1996
36
Pyomyositis during induction chemotherapy for acute lymphocytic leukemia. (8689354)
1996
37
p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia. (7780130)
1995
38
Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia. (1731053)
1992
39
From the Centers of Disease Control. Availability of varicella vaccine for children with acute lymphocytic leukemia. (1316974)
1992
40
Early diagnosis of leukoencephalopathy of acute lymphocytic leukemia by MRI. (1797008)
1991
41
Phase II trial of mitoxantrone in acute lymphocytic leukemia of childhood. A Pediatric Oncology Group study. (1783526)
1991
42
Mixed-lineage leukemia revisited: acute lymphocytic leukemia with myeloperoxidase-positive blasts by electron microscopy. (2166608)
1990
43
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. (2323651)
1990
44
Thyroid adenoma following treatment of acute lymphocytic leukemia. (2198824)
1990
45
Update of the cytogenetic study of childhood non-high-risk acute lymphocytic leukemia at diagnosis in protocol VI of the Dutch Childhood Leukemia Study Group. (2138993)
1990
46
An unusual t(9;12)(p13;q24) in childhood acute lymphocytic leukemia. (2702632)
1989
47
Eaton-Lambert syndrome in a patient with acute T cell lymphocytic leukemia. (3059524)
1988
48
Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. (3475171)
1987
49
The in vivo distribution of indium-111 labeled in vitro alloactivated syngeneic lymphocytes in a patient with relapsed acute myelomonocytic leukemia: implications for adoptive chemoimmunotherapy. (6387300)
1984
50
Klinefelter's syndrome and acute non-lymphocytic leukemia. (7059687)
1982

Genetic Variations for Acute Lymphocytic Leukemia

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute Lymphocytic Leukemia:

62
id Symbol AA change Variation ID SNP ID
1PAX5p.Gly183SerVAR_070682
2PAX5p.Gly183SerVAR_070682

Expression for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
4Cell Signaling Technology, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1dihydrofolate4410.9MTHFR, MTR, SHMT1, TYMS, CDKN2B
2b vitamins4410.9TYMS, SHMT1, MTR, MTHFR
3folate4410.9MTHFR, MTR, SHMT1, TYMS, IKZF1
4tetrahydrofolate4410.9TYMS, SHMT1, MTR, MTHFR
5vitamin b64410.9MTHFR, MTR, SHMT1, TYMS
6pyridoxal 5-phosphate4410.9TYMS, SHMT1, MTR, MTHFR
7methotrexate44 49 1112.9MTHFR, MTR, SHMT1, TYMS, CDKN2B
8serine4410.9BCR, TAL1, CDKN2B
9cytarabine44 49 1112.9BCR, MME, CDKN2B, TYMS
10Tetrahydrofolic acid11 2411.9SHMT1, MTR, MTHFR
11purine44 2411.9MTHFR, MTR, SHMT1, TYMS
12thymidine44 2411.9MTHFR, TYMS, CDX2, MME, BCR
13thymidylate4410.9TYMS, SHMT1, MTR, MTHFR
145-aza-2deoxycytidine4410.9CDKN1C, CDX2, CDX1, CDKN2B
15methyl-group4410.9MTHFR, MTR
16ch2h4folate4410.8MTHFR, TYMS
17creatinine4410.8TYMS, MME, PAX5
18adenosylcobalamin44 2411.8MTR, MTHFR
195,10-methenyltetrahydrofolate4410.8MTR, MTHFR
20vitamin b124410.8TYMS, MTR, MTHFR
21pemetrexed49 1111.8MTHFR, TYMS
22retinoic acid44 2411.8MTHFR, CDKN2B, CDX1, HOXD4, TAL1, MME
23methylcobalamin44 2411.8MTHFR, MTR
24cyanocobalamin49 11 2412.8MTHFR, MTR
25hydroxocobalamin44 1111.8MTHFR, MTR
2610-formyltetrahydrofolate4410.7MTHFR, MTR
27methionine4410.7MTHFR, MTR, SHMT1, MME
28cysteine4410.7MTHFR, MTR, TYMS, CDX2, MME, BCR
295-methyltetrahydrofolate44 1111.7MTR, MTHFR
30betaine44 2411.6MTR, MTHFR
31homocysteine44 2411.6MTHFR, MTR, SHMT1
32oligonucleotide4410.6BCR, PAX5, TAL1, CDX2, NUP98
33risedronate44 59 49 28 1114.5PAX5, TYMS
34cystathionine4410.5MTHFR, MTR
35capecitabine44 49 1112.4MTHFR, TYMS
36methylmalonic acid44 2411.2MTR, MTHFR

GO Terms for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
16Gene Ontology
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Cellular components related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.6PAX5, TYMS, GIMAP4, CDKN2B, CDX1, CDKN1C

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594410.8PAX5, TCF3, TAL1, IKZF1, CDX1, CDKN2B
2tetrahydrofolate interconversionGO:03599910.7MTHFR, SHMT1
3megakaryocyte differentiationGO:03021910.7TAL1, CDKN2B
4Peyers patch developmentGO:04854110.7TCF3, IKZF1
5folic acid metabolic processGO:04665510.6SHMT1, MTHFR
6water-soluble vitamin metabolic processGO:00676710.6MTHFR, MTR, SHMT1
7negative regulation of transcription from RNA polymerase II promoterGO:00012210.6PAX5, TAL1, IKZF1, CDKN1C, CDX2
8vitamin metabolic processGO:00676610.5MTHFR, MTR, SHMT1
9negative regulation of phosphorylationGO:04232610.5CDKN1C, CDKN2B
10organ morphogenesisGO:00988710.4PAX5, CDX2, CDX1
11natural killer cell differentiationGO:00177910.2TCF3, IKZF1

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.5TAL1, CDX1
2sequence-specific DNA binding transcription factor activityGO:00370010.5PAX5, CDX2, HOXD4, IKZF1, TAL1, TCF3
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1C, CDKN2B

Products for genes affiliated with Acute Lymphocytic Leukemia

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  • Antibodies
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  • Lysates
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Sources for Acute Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet