MCID: ACT074
MIFTS: 55

Acute Lymphocytic Leukemia

Categories: Cancer diseases, Immune diseases, Rare diseases, Genetic diseases, Blood diseases

Aliases & Classifications for Acute Lymphocytic Leukemia

MalaCards integrated aliases for Acute Lymphocytic Leukemia:

Name: Acute Lymphocytic Leukemia 38 12 41 14 69
Precursor Cell Lymphoblastic Leukemia Lymphoma 69
Acute Lymphoblastic Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9952
ICD10 33 C91.0 C91.00
ICD9CM 35 204.0
NCIt 47 C3167
UMLS 69 C0023449

Summaries for Acute Lymphocytic Leukemia

MedlinePlus : 41 leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards based summary : Acute Lymphocytic Leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to acute lymphoblastic leukemia, childhood and hemolytic anemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Acute Lymphocytic Leukemia is ACTB (Actin Beta), and among its related pathways/superpathways are Pathways in cancer and Transcriptional misregulation in cancer. The drugs Marqibo and Arranon have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

Related Diseases for Acute Lymphocytic Leukemia

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 3 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 2 Adult Acute Lymphocytic Leukemia
Chronic Lymphocytic Leukemia

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
id Related Disease Score Top Affiliating Genes
1 acute lymphoblastic leukemia, childhood 33.0 ETV6 MTHFR PAX5 RUNX1 TAL1
2 hemolytic anemia 29.5 BCR CDKN2B ETV6 NOTCH1 PAX5 RUNX1
3 acute monocytic leukemia 28.0 ASNS CDKN2A CDKN2B ETV6 MME MTHFR
4 adult acute lymphocytic leukemia 12.3
5 t-cell adult acute lymphocytic leukemia 12.0
6 b-cell adult acute lymphocytic leukemia 12.0
7 t-cell childhood acute lymphocytic leukemia 12.0
8 leukemia, acute lymphoblastic 11.7
9 leukemia 11.5
10 acute leukemia 11.3
11 childhood leukemia 11.3
12 precursor t-cell acute lymphoblastic leukemia 11.1
13 leukemia, acute lymphoblastic 3 11.1
14 ataxia-telangiectasia 11.0
15 testis seminoma 10.8 CDKN2A MME
16 deafness, autosomal recessive 8/10 10.8 ETV6 RUNX1
17 hypertonia 10.8 MTHFR TYMS
18 plasmodium vivax malaria 10.8 MME RUNX1
19 congenital sucrase-isomaltase deficiency without starch intolerance 10.8 NOTCH1 TP53
20 cervical adenoid cystic carcinoma 10.7 CDKN2A TP53
21 lymphoma, large-cell, immunoblastic 10.7 CDKN2B MME NOTCH1 TAL1
22 lymphoma, small cleaved-cell, diffuse 10.7 BCR ETV6 RUNX1
23 col12a1-related muscle diseases 10.7 BCR RUNX1 TYMS
24 idiopathic syringomyelia 10.6 BCR CDKN2A NOTCH1 TAL1
25 duodenal ulcer 10.6 BCR NOTCH1 TP53
26 split hand split foot nystagmus 10.6 CDKN2A TP53
27 phalanx chondroma 10.6 CDKN2A NOTCH1 TP53
28 penis paget's disease 10.6 CDKN2A CDKN2B TP53
29 tracheal disease 10.6 CDKN2A NOTCH1 TP53
30 cystic lymphangioma 10.6 CDKN2A CDKN2B TP53
31 gastrointestinal neuroendocrine tumor 10.6 CDKN2A MTHFR TP53
32 hepatic osteogenic sarcoma 10.6 MME PAX5 TP53
33 thai symphalangism syndrome 10.6 NOTCH1 TP53
34 atrophic gastritis 10.6 CDKN2A CDKN2B TP53
35 leiomyoma cutis 10.6 CDKN2A TP53
36 dubin-johnson syndrome 10.5 CDKN2A CDKN2B TP53
37 small cell sarcoma 10.5 CDKN2A CDKN2B TP53
38 non-distal trisomy 10q 10.5 ETV6 MTHFR TP53
39 nelson syndrome 10.5 BCR ETV6 RUNX1
40 anal squamous cell carcinoma 10.5 CDKN2A TP53
41 rete testis adenoma 10.5 NOTCH1 TP53
42 anaerobic pneumonia 10.5 CDKN2A NR3C1 TP53
43 gallbladder cancer 10.5 CDKN2A TP53 TYMS
44 spinal cord glioma 10.4 CDKN2A CDKN2B TP53
45 drug-induced hepatitis 10.4 MME PAX5 TP53
46 breast osteosarcoma 10.4 ETV6 MTHFR RUNX1 TP53
47 ritter's disease 10.4 CDKN2A TP53
48 bipolar disorder 10.4 CDKN2A MME PAX5 TP53
49 prostate cancer 10.3
50 rectum squamous cell carcinoma 10.3 CDKN2A TP53

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Acute Lymphocytic Leukemia

UMLS symptoms related to Acute Lymphocytic Leukemia:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

44 (show all 15)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 ACTB ASNS BCR CDKN2A ETV6 MTHFR
2 homeostasis/metabolism MP:0005376 10.36 ACTB ANKS1B BCR CDKN2A CDKN2B ETV6
3 hematopoietic system MP:0005397 10.35 TP53 TPMT ACTB ASNS BCR CDKN2A
4 cellular MP:0005384 10.28 BCR CDKN2A CDKN2B ETV6 NBN NOTCH1
5 behavior/neurological MP:0005386 10.25 CDKN2A NBN NR3C1 PAX5 RUNX1 TAL2
6 immune system MP:0005387 10.25 ACTB BCR CDKN2A CDKN2B ETV6 MME
7 mortality/aging MP:0010768 10.2 TAL1 TAL2 TP53 TPMT ACTB BCR
8 endocrine/exocrine gland MP:0005379 10.16 CDKN2B ETV6 NBN NOTCH1 NR3C1 RUNX1
9 embryo MP:0005380 10.13 ACTB CDKN2A ETV6 NBN NOTCH1 RUNX1
10 integument MP:0010771 10.1 CDKN2B ETV6 MME MTHFR NOTCH1 NR3C1
11 nervous system MP:0003631 10 PAX5 RUNX1 TAL1 TAL2 TP53 ACTB
12 liver/biliary system MP:0005370 9.97 ACTB BCR CDKN2A MME NOTCH1 NR3C1
13 neoplasm MP:0002006 9.91 ACTB CDKN2A CDKN2B ETV6 NBN NOTCH1
14 no phenotypic analysis MP:0003012 9.56 ACTB CDKN2A CDKN2B ETV6 MTHFR NR3C1
15 skeleton MP:0005390 9.28 ANKS1B CDKN2A MTHFR NOTCH1 NR3C1 PAX5

Drugs & Therapeutics for Acute Lymphocytic Leukemia

FDA approved drugs:

(show all 7)
id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Marqibo 17 46 VINCRISTINE SULFATE Talon Therapeutics August 2012
2
Arranon 17 46 NELARABINE GlaxoSmithKline October 2005
3
Blincyto 17 46 BLINATUMOMAB Amgen December 2014
4
Clolar 17 46 CLOFARABINE Genzyme December, 2004
5
Erwinaze 17 46 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
6
Iclusig 17 46 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
7
Sprycel 17 46 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 620)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
3
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 147-94-4 6253
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
5
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
6
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
7
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
11
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
12
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
13
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
14
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
15
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
16
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
17
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
18
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
19
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
20
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
21
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
22
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
23
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
25 Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
26
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
27
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
28
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
29
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
30
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
31
Oprelvekin Approved, Investigational Phase 4 145941-26-0
32
Menthol Approved Phase 4 2216-51-5 16666
33
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
34
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
35
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
36
Nicotine Approved Phase 4 54-11-5 942 89594
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
39
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
41
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
42
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
43
Butyric Acid Experimental Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
44
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
45 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Adjuvants, Immunologic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
47 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
50 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1714)

id Name Status NCT ID Phase Drugs
1 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
2 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
3 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
4 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
5 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
6 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
7 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
8 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
9 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
10 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
11 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
12 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
13 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
14 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
15 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
16 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
17 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
18 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
19 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
20 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
21 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
22 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
23 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
24 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
25 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
26 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
27 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
28 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
29 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
30 Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS Recruiting NCT01540812 Phase 4 Vincristine in induction;Daunorubicin in induction;Prednisone in induction;Metotrexato in induction;Cytarabine in induction;Hydrocortisone in induction;Idarubicin in induction-2;Fludarabine in induction-2;Ara-C in induction-2;G-CSF in induction-2;Dexamethasone in consolidation-1;Vincristrine in consolidation-1;Metotrexato in consolidation-1;PEG-ASP in consolidation-1;Dexamethasone in consolidation-2;ARA-C in consolidation-2;PEG-ASP in consolidation-2;Dexamethasone in consolidation-3;Vincristine in consolidation-3;Metotrexato in consolidation-3;PEG-ASP in consolidation-3
31 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
32 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
33 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
34 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
35 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
36 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
37 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
38 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
39 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Active, not recruiting NCT01200355 Phase 4 micafungin;posaconazole
40 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
41 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Not yet recruiting NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
42 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
43 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
44 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
45 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
46 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
47 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
48 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
49 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
50 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

39
T Cells, Bone, Bone Marrow, B Cells, Myeloid, Testes, Kidney

Publications for Acute Lymphocytic Leukemia

Articles related to Acute Lymphocytic Leukemia:

(show top 50) (show all 614)
id Title Authors Year
1
Blinatumomab (Blincyto): lessons learned from the bispecific t-cell engager (BiTE) in acute lymphocytic leukemia (ALL). ( 28379283 )
2017
2
Hyper-CVAD + epratuzumab as a salvage regimen for younger patients with relapsed/refractory CD22-positive precursor B-cell acute lymphocytic leukemia. ( 28154086 )
2017
3
The correlation between Pax5 deletion and patients survival in Iranian children with precursor B-cell acute lymphocytic leukemia. ( 28886309 )
2017
4
TS Gene Polymorphisms Correlate with Susceptibility to Acute Lymphocytic Leukemia in Children. ( 28646637 )
2017
5
Treatment of Philadelphia Chromosome-Positive Acute Lymphocytic Leukemia. ( 28382538 )
2017
6
Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. ( 28670495 )
2017
7
Diagnosis of Lymphoid Malignancy by PCR for Analysis of Antigen Receptor Rearrangement after Blood Transfusion in a Dog with Acute Lymphocytic Leukemia. ( 28860956 )
2017
8
New Therapeutic Strategies in Acute Lymphocytic Leukemia. ( 28353016 )
2017
9
Immunization practices in acute lymphocytic leukemia and post-hematopoietic stem cell transplant in Canadian Pediatric Hematology/Oncology centers. ( 26962702 )
2016
10
Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors. ( 27094799 )
2016
11
Extramedullary Involvement of the Sigmoid Colon with Acute Lymphocytic Leukemia. ( 27189376 )
2016
12
Acute lymphocytic leukemia presenting as a single brain mass. ( 27430416 )
2016
13
Recent advances and novel treatment paradigms in acute lymphocytic leukemia. ( 27695616 )
2016
14
Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia. ( 27599414 )
2016
15
Recurrence of acute lymphocytic leukemia as spinal epidural mass. ( 26778825 )
2016
16
Campylobacter jejuni Bacteremia in a Patient With Acute Lymphocytic Leukemia. ( 27621914 )
2016
17
Allogeneic bone marrow transplantation for therapy-related acute lymphocytic leukemia after autologous hematopoietic stem cell transplantation for multiple myeloma. ( 27473192 )
2016
18
Acute lymphocytic leukemia mimicking spondyloarthritis in an adolescent: A case report and review of the literature. ( 26893708 )
2016
19
Novel Approaches for the Interim Management of Relapsed/Refractory Acute Lymphocytic Leukemia: Introduction. ( 27007406 )
2016
20
B Cell Acute Lymphocytic Leukemia Presenting as a Bile Duct Stricture Diagnosed With Cholangioscopy. ( 27807569 )
2016
21
Blinatumomab: A New Treatment for Adults With Relapsed Acute Lymphocytic Leukemia. ( 26991709 )
2016
22
BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients. ( 27123097 )
2016
23
Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia. ( 27987364 )
2016
24
Secondary glioma following acute lymphocytic leukemia: therapeutic implications. ( 27159974 )
2016
25
A single black ulcer in a child with acute lymphocytic leukemia. ( 28099607 )
2016
26
Disseminated Mycobacterium abscessus Complex Infection Manifesting as Multiple Areas of Lymphadenitis and Skin Abscess in the Preclinical Stage of Acute Lymphocytic Leukemia. ( 27374685 )
2016
27
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. ( 27301866 )
2016
28
Catheter-related bloodstream infection due to Gordonia sputi in a patient with acute lymphocytic leukemia: a Case Report. ( 26902218 )
2016
29
Potent anti-leukemia activities of chimeric antigen receptor modified T cells against CD19 in Chinese patients with relapsed/refractory acute lymphocytic leukemia. ( 28039267 )
2016
30
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )
2016
31
Multiple unusual lung etiologies in a child with acute lymphocytic leukemia. ( 27616461 )
2016
32
Expression of CD56 is a risk factor for acute lymphocytic leukemia with central nervous system involvement in adults. ( 27734763 )
2016
33
Myelodysplastic Syndrome and Acute Lymphocytic Leukemia in Common Variable Immunodeficiency (CVID). ( 26993985 )
2016
34
Palifermin and Chlorhexidine Mouthwashes in Prevention of Chemotherapy-Induced Mucositis in Children with Acute Lymphocytic Leukemia: a Randomized Controlled Trial. ( 27942550 )
2016
35
Role of peripheral blood minimum residual disease at day 8 of induction therapy in high-risk pediatric patients with acute lymphocytic leukemia. ( 27526794 )
2016
36
Treating adults with acute lymphocytic leukemia: new pharmacotherapy options. ( 27759440 )
2016
37
A rare case of chemotherapy induced reversible cerebral vasoconstriction syndrome in a patient of acute lymphocytic leukemia. ( 26881572 )
2015
38
Subcutaneous adipose tissue plays a beneficial effect on subclinical atherosclerosis in young survivors of acute lymphocytic leukemia. ( 26316772 )
2015
39
Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia. ( 26661660 )
2015
40
Successful Pregnancy and Delivery After Radiation With Ovarian Shielding for Acute Lymphocytic Leukemia Before Menarche. ( 25739028 )
2015
41
Myeloid Antigen-positive T Cell Acute Lymphocytic Leukemia with t(14;18) and Trisomy 10: Report of a Case and Literature Review. ( 26265522 )
2015
42
Tetramethylpyrazine inhibits the proliferation of acute lymphocytic leukemia cell lines via decrease in GSK-3I^. ( 25812605 )
2015
43
Acute Lymphocytic Leukemia with Bilateral Renal Masses Masquerading as Nephroblastomatosis. ( 26613060 )
2015
44
Mechanistic Study of the Phytocompound, 2- I^ -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches. ( 26557148 )
2015
45
Incidental detection of congenital Robertsonian translocation at diagnosis of Philadelphia chromosome-positive acute lymphocytic leukemia. ( 26062669 )
2015
46
L-asparaginase and venous thromboembolism in acute lymphocytic leukemia. ( 26274336 )
2015
47
Comparative study of quality of life of adult survivors of childhood acute lymphocytic leukemia and Wilms' tumor. ( 26537509 )
2015
48
Prognostic Significance of Lymphoid Enhancer-Binding Factor-1 Expression in Egyptian Adult B-Acute Lymphocytic Leukemia Patients. ( 25805670 )
2015
49
Acute Lymphocytic Leukemia in Adults. Pathologic Features and Prognosis. ( 26076558 )
2015
50
The clinical potential of inotuzumab ozogamicin in relapsed and refractory acute lymphocytic leukemia. ( 26425338 )
2015

Variations for Acute Lymphocytic Leukemia

ClinVar genetic disease variations for Acute Lymphocytic Leukemia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NBN NM_002485.4(NBN): c.511A> G (p.Ile171Val) single nucleotide variant risk factor rs61754966 GRCh37 Chromosome 8, 90990521: 90990521
2 ACTB NP_001092.1(ACTB): p.Val209Leu protein only Pathogenic

Expression for Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for Acute Lymphocytic Leukemia

Pathways related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.95 BCR CDKN2A CDKN2B RUNX1 TP53
2 11.71 ETV6 PAX5 RUNX1 TP53
3 10.3 CDKN2A CDKN2B TP53

GO Terms for Acute Lymphocytic Leukemia

Cellular components related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.55 ACTB ANKS1B ASNS BCR CDKN2A CDKN2B

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.85 ETV6 NOTCH1 NR3C1 PAX5 TAL1 TP53
2 definitive hemopoiesis GO:0060216 9.54 BCR TAL1
3 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.51 NBN TP53
4 hematopoietic stem cell proliferation GO:0071425 9.49 ETV6 RUNX1
5 tetrahydrofolate interconversion GO:0035999 9.46 MTHFR TYMS
6 cell cycle arrest GO:0007050 9.46 CDKN2A CDKN2B NBN TP53
7 tetrahydrofolate metabolic process GO:0046653 9.43 MTHFR TYMS
8 somatic stem cell division GO:0048103 9.4 CDKN2A NOTCH1
9 response to folic acid GO:0051593 9.32 MTHFR TYMS
10 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.28 CDKN2A CDKN2B ETV6 NOTCH1 NR3C1 PAX5
11 megakaryocyte differentiation GO:0030219 9.26 CDKN2B TAL1
12 regulation of myeloid cell differentiation GO:0045637 9.18 TAL1
13 replicative senescence GO:0090399 9.13 CDKN2A MME TP53
14 transcription, DNA-templated GO:0006351 10.18 CDKN2A ETV6 NOTCH1 NR3C1 PAX5 RUNX1

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.5 ETV6 NOTCH1 NR3C1 PAX5 RUNX1 TAL1
2 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.46 ETV6 TAL1 TAL2 TP53
3 core promoter binding GO:0001047 9.43 NOTCH1 NR3C1 RUNX1
4 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.32 CDKN2A CDKN2B
5 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.02 ETV6 RUNX1 TAL1 TAL2 TP53

Sources for Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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