ALL
MCID: ACT074
MIFTS: 77

Acute Lymphocytic Leukemia (ALL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Acute Lymphocytic Leukemia

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to acute leukemia and leukemia. An important gene associated with Acute Lymphocytic Leukemia is BCR (breakpoint cluster region), and among its related pathways are Lymphocyte Signaling and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds dihydrofolate and b vitamins have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are mortality/aging and hematopoietic system.

Wikipedia:63 Acute lymphoblastic leukemia (ALL) is a form of leukemia, or cancer of the white blood cells... more...

Description from OMIM:46 613065,613067,247640

Aliases & Classifications for Acute Lymphocytic Leukemia

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 9diseasecard, 46OMIM, 44Novoseek, 39NCIt, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acute lymphocytic leukemia:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute lymphocytic leukemia 8 42 48 33 30 60
acute lymphoblastic leukemia 8 42 48
leukemia, acute lymphoblastic 9 46
all 42 48
leukemia, acute lymphoblastic, susceptibility to 9
acute lymphoblastic leukemia/lymphoma 48
lymphoblastic leukemia acute 44
leukemia, acute lymphocytic 46


External Ids:

Disease Ontology8 DOID:9952
NCIt39 C3167
ICD9CM27 204.0
ICD10 via Orphanet26 C91.0
ICD1025 C91.0

Related Diseases for Acute Lymphocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1419)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.1NUP98, TAL1, PAX5, BCR, MTHFR, CDKN2B
2leukemia32.1TAL1, MTHFR, MTR, ANKS1B, TYMS, NUP98
3adult acute lymphocytic leukemia31.6SHMT1, TYMS, CDKN2B
4myeloid leukemia30.8CDKN2B, NUP98, BCR
5non-hodgkin lymphoma30.7PAX5, BCR, CDKN2B, MTR, IKZF1, TAL1
6acute lymphoblastic leukemia, childhood30.7BCR, MME, IKZF1, CDKN2B, MTHFR, TYMS
7burkitt's lymphoma30.6MME, PAX5, BCR
8retinoblastoma30.5TYMS, CDKN2B, BCR, CDKN1C
9rheumatoid arthritis30.5MME, MTHFR
10myeloma30.4CDKN2B, PAX5, BCR
11chronic myeloid leukemia30.4BCR, TAL1, IKZF1, CDKN1C, CDKN2B, NUP98
12precursor b-cell acute lymphoblastic leukemia30.3MME, CDKN2B, PAX5, BCR
13precursor t-cell acute lymphoblastic leukemia30.3TYMS, NUP98, BCR, PAX5, IKZF1, CDKN2B
14prostate cancer30.3MME, BCR, CDKN2B, CDX2
15hepatocellular carcinoma30.2CDKN2B, CDX2, MME, BCR, CDKN1C
16melanoma30.1CDKN2B, MME, CDX2
17lung cancer30.1TYMS
18esophagitis30.1CDX2, CDX1
19osteosarcoma30.1TYMS
20adenoma30.1CDKN1C, CDX2, CDX1, MTR, MTHFR
21breast cancer30.1SHMT1, CDKN1C, CDX2, MTHFR, MTR, MME
22glioblastoma multiforme30.1CDKN1C, CDKN2B
23down syndrome30.1MTR, MTHFR
24meningioma30.1CDKN2B
25adenocarcinoma30.1MME, CDX2, CDX1, CDKN1C, TYMS
26pancreatic cancer30.1CDKN1C, CDX2, TYMS
27colorectal cancer29.9MTHFR, SHMT1, TYMS, CDX2, MTR, CDKN1C
28colon cancer29.8MTHFR, MTR, CDX1, CDKN2B, CDX2, TYMS
29ovarian cancer29.8TYMS, MME
30spina bifida29.8MTHFR, MTR
31malignant mesothelioma29.8TYMS, CDKN2B
32migraine29.7MTHFR
33cholangiocarcinoma29.6CDX2, MME
34gallbladder cancer29.6TYMS, CDX2
35bladder carcinoma29.4TYMS
36hematologic cancer29.4PAX5, BCR, CDKN1C, CDKN2B, NUP98, IKZF1
37childhood leukemia11.0
38acute t cell leukemia10.8
39t-cell leukemia10.8
40chronic lymphocytic leukemia10.6
41hemophagocytic lymphohistiocytosis10.6
42acute myeloid leukemia10.5
43acute pancreatitis10.5
44fusariosis10.5
45obesity10.5
46pancreatitis10.5
47central nervous system leukemia10.5
48noonan syndrome10.5
49hyperphosphatemia10.5
50arthritis10.5

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to acute lymphocytic leukemia

Clinical Features for Acute Lymphocytic Leukemia

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

613065,613067,247640

Drugs & Therapeutics for Acute Lymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Lymphocytic Leukemia

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Search CenterWatch for Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Lymphocytic Leukemia

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Anatomical Context for Acute Lymphocytic Leukemia

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

32
Bone, Bone marrow, T cells, B cells, Skin, Testes, Myeloid, Liver, Monocytes, Thyroid, Breast, Kidney, Brain, Prostate, Spleen, Whole blood, Endothelial, Pineal

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Acute Lymphocytic Leukemia or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.8BCR, MTHFR, MTR, SHMT1, NUP98, CDKN2B
2MP:000539710.7NUP98, CDKN2B, CDX1, CDKN1C, IKZF1, TAL2
3MP:000537810.7CDKN1C, CDX2, NUP98, MTHFR, HOXD4, IKZF1
4MP:000538710.6CDKN1C, CDKN2B, NUP98, GIMAP4, IKZF1, TAL1
5MP:000538410.6CDKN2B, CDX2, CDKN1C, IKZF1, TAL1, TCF3
6MP:000537610.5CDKN2B, SHMT1, MTR, MTHFR, CDX2, CDKN1C
7MP:000539010.2CDX1, CDX2, CDKN1C, HOXD4, TAL1, PAX5

Publications for Acute Lymphocytic Leukemia

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Sources:
50PubMed
See all sources

Articles related to Acute Lymphocytic Leukemia:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Native kidney BK virus nephropathy associated with acute lymphocytic leukemia. (23443506)
2013
2
Chemotherapy followed by modified donor lymphocyte infusion as a treatment for relapsed acute leukemia after haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion: superior outcomes compared with chemotherapy alone and an analysis of prognostic factors. (23837640)
2013
3
Recent advancements of bortezomib in acute lymphocytic leukemia treatment. (23295437)
2013
4
Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10A years. (21181316)
2011
5
Deficiency of complement factor MBL in a patient required cardiac surgery after an acute myocardial infarction with underlining chronic lymphocytic leukemia. (19038464)
2010
6
Glycogen synthase kinase-3I^ inhibition induces nuclear factor-I_B-mediated apoptosis in pediatric acute lymphocyte leukemia cells. (21110852)
2010
7
Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation. (18784923)
2009
8
How I treat acute lymphocytic leukemia in adults. (17596539)
2007
9
Clonal evolution with +11q 13, t(1;7) and t(1;4) at relapse in a patient with Ph positive acute lymphocytic leukemia (ALL) treated with single agent front line imatinib followed by dasatinib. (17852464)
2007
10
Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia. (17209054)
2007
11
Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia. (17344919)
2007
12
Differential expression of histone post-translational modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry. (14698558)
2004
13
Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia. (15133630)
2004
14
Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival. (14684422)
2004
15
Analysis of microsatellite instability in children treated for acute lymphocytic leukemia with elevated HPRT mutant frequencies. (15388815)
2004
16
Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. (14559839)
2003
17
Cutaneous lymphocytic vasculitis as the presenting feature of acute lymphoblastic leukemia. (12368694)
2002
18
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
19
Double Philadelphia chromosomes in acute lymphocytic leukemia. (10991618)
2000
20
Philadelphia chromosome positive acute lymphocytic leukemia arising from aplastic anemia. (10679810)
2000
21
Central nervous system involvement of Epstein-Barr virus lymphoproliferative disease in a patient with acute lymphocytic leukemia. (10779033)
2000
22
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
23
Becoming a cancer patient: a study of families of children with acute lymphocytic leukemia. (9989016)
1999
24
Chronic parvovirus B19 meningitis in a child with acute lymphocytic leukemia. (10223704)
1999
25
Acute lymphocytic leukemia in the adolescent: diagnosis, treatment, and outcomes. (10611938)
1999
26
Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine. (9683281)
1998
27
Pseudomonas aeruginosa blepharoconjunctivitis during cytoreductive chemotherapy in a woman with acute lymphocytic leukemia. (9368482)
1997
28
Exclusive p15INK4B gene deletions in acute lymphocytic leukemia include the E1 beta exon of the p16INK4 gene. (8608263)
1996
29
Malignant external otitis as the presentation of childhood acute lymphocytic leukemia. (8970229)
1996
30
Acute lymphocytic leukemia: a comprehensive review with emphasis on biology and therapy. (8724635)
1996
31
Complete remission achieved by low-dose Ara-C, aclarubicin and rhG-CSF (CAG) therapy in acute non-lymphocytic leukemia with monosomy 7 occurring after severe aplastic anemia]. (7536277)
1995
32
Acute lymphocytic leukemia in adults: an update. (8140553)
1994
33
Glutathione peroxidase activities in serum and cerebrospinal fluid from patients with acute lymphocytic leukemia. (8192163)
1994
34
The role of bone marrow transplantation in adult acute lymphocytic leukemia. (8338797)
1993
35
Demyelinating neuropathy and acute lymphocytic leukemia. (8445952)
1993
36
Deletions of the short arm of chromosome 9, including the interferon-alpha/-beta genes, in acute lymphocytic leukemia. Studies on loss of heterozygosity, parental origin of deleted genes and prognosis. (8100807)
1993
37
Adult and childhood acute lymphocytic leukemia: are they different diseases? (8416287)
1993
38
Chemotherapy-related side effects in children with acute lymphocytic leukemia in Taiwan: a nursing perspective. (1514401)
1992
39
X;6 translocation in a child with congenital acute lymphocytic leukemia. (1730130)
1992
40
Overexpression of c-fos in a human pre-B cell acute lymphocytic leukemia derived cell line, SMS-SB. (1704120)
1991
41
Evaluation of cytogenetic samples and pertinent technical variables in adult acute lymphocytic leukemia. (2009514)
1991
42
Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: correlation with neuropsychologic deficiencies. (2052695)
1991
43
Abnormal cerebral glucose metabolism in long-term survivors of childhood acute lymphocytic leukemia. (2042943)
1991
44
Epstein-Barr virus infection in Chediak-Higashi syndrome mimicking acute lymphocytic leukemia. (2165746)
1990
45
Growth factor-dependent differentiation along the myeloid and lymphoid lineages in an immature acute T lymphocytic leukemia. (2246514)
1990
46
Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children. (2355954)
1990
47
Acute monocytic leukemia with B cell markers expression following B chronic lymphocytic leukemia. (2587203)
1989
48
Acute transformation of chronic large granular lymphocyte leukemia associated with additional chromosome abnormality. (2731121)
1989
49
Cytomegalovirus oophoritis with cortical necrosis during remission of acute lymphocytic leukemia. (2847481)
1988
50
T cell acute lymphocytic leukemia terminating as malignant histiocytosis. (306197)
1978

Genetic Variations for Acute Lymphocytic Leukemia

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute Lymphocytic Leukemia:

62
id Symbol AA change Variation ID SNP ID
1PAX5p.Gly183SerVAR_070682
2PAX5p.Gly183SerVAR_070682

Expression for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
4Cell Signaling Technology, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 53Reactome
See all sources

Compounds for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1dihydrofolate4410.9MTHFR, MTR, SHMT1, TYMS, CDKN2B
2b vitamins4410.9TYMS, SHMT1, MTR, MTHFR
3folate4410.9MTHFR, MTR, SHMT1, TYMS, IKZF1
4tetrahydrofolate4410.9TYMS, SHMT1, MTR, MTHFR
5vitamin b64410.9MTHFR, MTR, SHMT1, TYMS
6pyridoxal 5-phosphate4410.9TYMS, SHMT1, MTR, MTHFR
7methotrexate44 49 1112.9MTHFR, MTR, SHMT1, TYMS, CDKN2B
8serine4410.9BCR, TAL1, CDKN2B
9cytarabine44 49 1112.9BCR, MME, CDKN2B, TYMS
10Tetrahydrofolic acid11 2411.9SHMT1, MTR, MTHFR
11purine44 2411.9MTHFR, MTR, SHMT1, TYMS
12thymidine44 2411.9MTHFR, TYMS, CDX2, MME, BCR
13thymidylate4410.9TYMS, SHMT1, MTR, MTHFR
145-aza-2deoxycytidine4410.9CDKN1C, CDX2, CDX1, CDKN2B
15methyl-group4410.9MTHFR, MTR
16ch2h4folate4410.8MTHFR, TYMS
17creatinine4410.8TYMS, MME, PAX5
18adenosylcobalamin44 2411.8MTR, MTHFR
195,10-methenyltetrahydrofolate4410.8MTR, MTHFR
20vitamin b124410.8TYMS, MTR, MTHFR
21pemetrexed49 1111.8MTHFR, TYMS
22retinoic acid44 2411.8MTHFR, CDKN2B, CDX1, HOXD4, TAL1, MME
23methylcobalamin44 2411.8MTHFR, MTR
24cyanocobalamin49 11 2412.8MTHFR, MTR
25hydroxocobalamin44 1111.8MTHFR, MTR
2610-formyltetrahydrofolate4410.7MTHFR, MTR
27methionine4410.7MTHFR, MTR, SHMT1, MME
28cysteine4410.7MTHFR, MTR, TYMS, CDX2, MME, BCR
295-methyltetrahydrofolate44 1111.7MTR, MTHFR
30betaine44 2411.6MTR, MTHFR
31homocysteine44 2411.6MTHFR, MTR, SHMT1
32oligonucleotide4410.6BCR, PAX5, TAL1, CDX2, NUP98
33risedronate44 59 49 28 1114.5PAX5, TYMS
34cystathionine4410.5MTHFR, MTR
35capecitabine44 49 1112.4MTHFR, TYMS
36methylmalonic acid44 2411.2MTR, MTHFR

GO Terms for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
16Gene Ontology
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Cellular components related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.6PAX5, TYMS, GIMAP4, CDKN2B, CDX1, CDKN1C

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594410.8PAX5, TCF3, TAL1, IKZF1, CDX1, CDKN2B
2tetrahydrofolate interconversionGO:03599910.7MTHFR, SHMT1
3megakaryocyte differentiationGO:03021910.7TAL1, CDKN2B
4Peyers patch developmentGO:04854110.7TCF3, IKZF1
5folic acid metabolic processGO:04665510.6SHMT1, MTHFR
6water-soluble vitamin metabolic processGO:00676710.6MTHFR, MTR, SHMT1
7negative regulation of transcription from RNA polymerase II promoterGO:00012210.6PAX5, TAL1, IKZF1, CDKN1C, CDX2
8vitamin metabolic processGO:00676610.5MTHFR, MTR, SHMT1
9negative regulation of phosphorylationGO:04232610.5CDKN1C, CDKN2B
10organ morphogenesisGO:00988710.4PAX5, CDX2, CDX1
11natural killer cell differentiationGO:00177910.2TCF3, IKZF1

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.5TAL1, CDX1
2sequence-specific DNA binding transcription factor activityGO:00370010.5PAX5, CDX2, HOXD4, IKZF1, TAL1, TCF3
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1C, CDKN2B

Products for genes affiliated with Acute Lymphocytic Leukemia

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Acute Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet