MCID: ACT074
MIFTS: 61

Acute Lymphocytic Leukemia

Categories: Blood diseases, Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Acute Lymphocytic Leukemia

MalaCards integrated aliases for Acute Lymphocytic Leukemia:

Name: Acute Lymphocytic Leukemia 37 12 72 40 14 69
Precursor Cell Lymphoblastic Leukemia Lymphoma 69
Acute Lymphoblastic Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9952
ICD10 32 C91.0 C91.00
ICD9CM 34 204.0
NCIt 46 C3167

Summaries for Acute Lymphocytic Leukemia

MedlinePlus : 40 Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. ALL is the most common type of cancer in children. Possible risk factors for ALL include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. Symptoms of ALL include: Weakness or feeling tired Fever Easy bruising or bleeding Bleeding under the skin Shortness of breath Weight loss or loss of appetite Pain in the bones or stomach Pain or a feeling of fullness below the ribs Painless lumps in the neck, underarm, stomach, or groin Tests that examine the blood and bone marrow diagnose ALL. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. NIH: National Cancer Institute

MalaCards based summary : Acute Lymphocytic Leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to childhood leukemia and acute leukemia, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Acute Lymphocytic Leukemia is ACTB (Actin Beta), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A lymphoblastic leukemia that is characterized by over production of lymphoblasts.

Wikipedia : 72 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Acute Lymphocytic Leukemia

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Adult Acute Lymphocytic Leukemia

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 childhood leukemia 32.4 ETV6 MTHFR RUNX1 TP53
2 acute leukemia 32.3 ETV6 MTHFR PAX5 RUNX1 TAL1
3 leukemia 32.3 BCR CDKN2A ETV6 MME RUNX1 TAL1
4 acute lymphoblastic leukemia, childhood 32.0 ASNS CDKN2A CDKN2B ETV6 MME MTHFR
5 leukemia, acute lymphoblastic 3 31.9 BCR CDKN2A CDKN2B ETV6 MME PAX5
6 precursor t-cell acute lymphoblastic leukemia 31.6 ASNS BCR CDKN2A CDKN2B ETV6 NOTCH1
7 lymphoblastic leukemia 30.8 BCR CDKN2A ETV6 NBN NOTCH1 PAX5
8 central nervous system leukemia 30.4 MME RUNX1
9 lymphoblastic lymphoma 30.3 CDKN2B MME NOTCH1 TAL1
10 leukemia, acute lymphoblastic 30.3 ACTB ASNS BCR CDKN2A CDKN2B ETV6
11 leukemia, acute myeloid 29.6 BCR CDKN2A CDKN2B ETV6 MME RUNX1
12 lymphoma, non-hodgkin, familial 29.4 BCR CDKN2B MME NBN PAX5
13 adult acute lymphocytic leukemia 12.4
14 b-cell adult acute lymphocytic leukemia 12.2
15 t-cell adult acute lymphocytic leukemia 12.2
16 t-cell childhood acute lymphocytic leukemia 12.1
17 ataxia-telangiectasia 11.1
18 fallopian tube endometrioid adenocarcinoma 10.6 CDKN2A MME
19 hemifacial spasm 10.5 MTHFR TYMS
20 platelet disorder, familial, with associated myeloid malignancy 10.5 ETV6 RUNX1
21 brain stem astrocytic neoplasm 10.5 CDKN2A TP53
22 splenic diffuse red pulp small b-cell lymphoma 10.5 NOTCH1 TP53
23 lymphoid leukemia 10.4 BCR ETV6 RUNX1
24 prostate cancer 10.4
25 squamous cell carcinoma of the oropharynx 10.4 CDKN2A TP53
26 richter's syndrome 10.4 BCR NOTCH1 TP53
27 bone squamous cell carcinoma 10.4 CDKN2A NOTCH1 TP53
28 thyroid lymphoma 10.4 CDKN2A CDKN2B TP53
29 scrotal carcinoma 10.4 CDKN2A CDKN2B TP53
30 spitz nevus 10.4 CDKN2A TP53
31 tetraploidy 10.4 NOTCH1 TP53
32 gastrointestinal system benign neoplasm 10.4 CDKN2A MTHFR TP53
33 grade iii astrocytoma 10.4 CDKN2A CDKN2B TP53
34 skin melanoma 10.3 CDKN2A CDKN2B TP53
35 nervous system cancer 10.3 CDKN2A CDKN2B TP53
36 melanoma, cutaneous malignant 1 10.3 CDKN2A CDKN2B TP53
37 keratinizing squamous cell carcinoma 10.3 CDKN2A TP53
38 invasive bladder transitional cell carcinoma 10.3 NOTCH1 TP53
39 bone marrow cancer 10.3 BCR ETV6 RUNX1
40 in situ carcinoma 10.3 CDKN2A NR3C1 TP53
41 gastrointestinal system cancer 10.3 CDKN2A TP53 TYMS
42 diffuse large b-cell lymphoma 10.3 MME PAX5 TP53
43 differentiated thyroid carcinoma 10.3 CDKN2A ETV6 MTHFR TP53
44 tenosynovial giant cell tumor 10.2 CDKN2A CDKN2B
45 papilloma 10.2 CDKN2A CDKN2B TP53 TYMS
46 squamous cell carcinoma of the larynx 10.2 CDKN2A TP53
47 oligodendroglioma 10.2 CDKN2A CDKN2B TP53
48 b-cell lymphomas 10.2 CDKN2A MME PAX5 TP53
49 lymphoma 10.1
50 hematologic cancer 10.0 BCR CDKN2B ETV6 NOTCH1 PAX5 RUNX1

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to Acute Lymphocytic Leukemia

Symptoms & Phenotypes for Acute Lymphocytic Leukemia

UMLS symptoms related to Acute Lymphocytic Leukemia:


edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 CDKN2B ETV6 BCR NOTCH1 ACTB CDKN2A
2 growth/size/body region MP:0005378 10.37 ASNS NBN ETV6 BCR NOTCH1 ACTB
3 hematopoietic system MP:0005397 10.35 NBN ASNS CDKN2B ETV6 BCR NOTCH1
4 behavior/neurological MP:0005386 10.34 NR3C1 ASNS NBN BCR ACTB CDKN2A
5 cellular MP:0005384 10.29 CDKN2A NBN CDKN2B ETV6 BCR NOTCH1
6 immune system MP:0005387 10.28 NR3C1 NBN CDKN2B ETV6 BCR NOTCH1
7 mortality/aging MP:0010768 10.25 NBN CDKN2B ETV6 BCR NOTCH1 ACTB
8 endocrine/exocrine gland MP:0005379 10.16 NBN CDKN2B ETV6 NOTCH1 ACTB CDKN2A
9 integument MP:0010771 10.14 NR3C1 CDKN2B ETV6 NOTCH1 MME CDKN2A
10 embryo MP:0005380 10.13 CDKN2A NBN ETV6 NOTCH1 ACTB RUNX1
11 digestive/alimentary MP:0005381 10.08 CDKN2A BCR ETV6 NOTCH1 TLX3 NR3C1
12 nervous system MP:0003631 10.03 NBN ASNS BCR NOTCH1 ACTB CDKN2A
13 liver/biliary system MP:0005370 9.97 BCR NOTCH1 MME ACTB CDKN2A NR3C1
14 neoplasm MP:0002006 9.96 NBN CDKN2B ETV6 NOTCH1 ACTB CDKN2A
15 no phenotypic analysis MP:0003012 9.56 CDKN2B ETV6 ACTB MTHFR CDKN2A RUNX1
16 skeleton MP:0005390 9.28 ANKS1B NOTCH1 MTHFR CDKN2A RUNX1 NR3C1

Drugs & Therapeutics for Acute Lymphocytic Leukemia

FDA approved drugs:

(show all 7)
# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Arranon 17 45 NELARABINE GlaxoSmithKline October 2005
2
Blincyto 17 45 BLINATUMOMAB Amgen December 2014
3
Clolar 17 45 CLOFARABINE Genzyme December, 2004
4
Erwinaze 17 45 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
5
Iclusig 17 45 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
6
Marqibo 17 45 VINCRISTINE SULFATE Talon Therapeutics August 2012
7
Sprycel 17 45 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 615)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
3
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 147-94-4 6253
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
5
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
6
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
7
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
10
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
11
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
12
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
13
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
14
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
15
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 23214-92-8 31703
16
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
17
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
18
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
19
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
20
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
21
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
22
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2 53643-48-4, 59917-39-4 40839
23
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
24
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 657311 5754
25
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
26 Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
27
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
28
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
29
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
30
Methylphenidate Approved, Investigational Phase 4 20748-11-2, 113-45-1 4158
31
Oprelvekin Approved, Investigational Phase 4 145941-26-0
32
Menthol Approved Phase 4 2216-51-5 16666
33
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
34
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
35
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
36
Nicotine Approved Phase 4 54-11-5 89594 942
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
38
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
39
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
41
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
42
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 31703
43
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
44
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
45 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Adjuvants, Immunologic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
47 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1723)

# Name Status NCT ID Phase Drugs
1 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
2 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
3 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
4 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
5 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
6 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
7 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
8 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
9 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
10 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
11 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
12 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
13 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
14 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
15 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
16 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
17 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
18 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
19 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
20 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
21 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
22 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
23 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
24 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
25 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
26 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
27 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
28 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
29 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
30 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
31 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
32 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
33 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
34 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
35 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
36 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
37 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
38 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
39 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
40 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Active, not recruiting NCT01200355 Phase 4 micafungin;posaconazole
41 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
42 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
43 ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia Terminated NCT00386997 Phase 4 liposomal amphotericin B (AmBisome®)
44 Atomoxetine for Children With Acquired Attentional Disorders Following Completion of Chemotherapy for ALL Terminated NCT00299234 Phase 4 Atomoxetine
45 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
46 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
47 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
48 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
49 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
50 Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia: Unknown status NCT02070523 Phase 3 VDCLD regimen

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

38
T Cells, Bone, Bone Marrow, B Cells, Myeloid, Testes, Kidney

Publications for Acute Lymphocytic Leukemia

Articles related to Acute Lymphocytic Leukemia:

(show top 50) (show all 620)
# Title Authors Year
1
Late effects awareness website for pediatric survivors of acute lymphocytic leukemia. ( 29451924 )
2018
2
Vaccine-associated paralytic poliomyelitis in a patient with acute lymphocytic leukemia. ( 29322435 )
2018
3
Incidence of acute lymphocytic leukemia in Calgary, Alberta, Canada: a retrospective cohort study. ( 29415769 )
2018
4
Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies. ( 29447943 )
2018
5
ASSESSMENT OF THE LATE EFFECTS ON BONES AND ON BODY COMPOSITION OF CHILDREN AND ADOLESCENTS TREATED FOR ACUTE LYMPHOCYTIC LEUKEMIA ACCORDING TO BRAZILIAN PROTOCOLS. ( 28977305 )
2017
6
The correlation between Pax5 deletion and patients survival in Iranian children with precursor B-cell acute lymphocytic leukemia. ( 28886309 )
2017
7
New Therapeutic Strategies in Acute Lymphocytic Leukemia. ( 28353016 )
2017
8
Hyper-CVAD + epratuzumab as a salvage regimen for younger patients with relapsed/refractory CD22-positive precursor B-cell acute lymphocytic leukemia. ( 28154086 )
2017
9
Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. ( 28670495 )
2017
10
TS Gene Polymorphisms Correlate with Susceptibility to Acute Lymphocytic Leukemia in Children. ( 28646637 )
2017
11
Treatment of Philadelphia Chromosome-Positive Acute Lymphocytic Leukemia. ( 28382538 )
2017
12
Blinatumomab (Blincyto): lessons learned from the bispecific t-cell engager (BiTE) in acute lymphocytic leukemia (ALL). ( 28379283 )
2017
13
Magnusiomyces capitatus Peritonitis in a Child With Acute Lymphocytic Leukemia as a Breakthrough Infection During Caspofungin Therapy. ( 29145348 )
2017
14
Diagnosis of Lymphoid Malignancy by PCR for Analysis of Antigen Receptor Rearrangement after Blood Transfusion in a Dog with Acute Lymphocytic Leukemia. ( 28860956 )
2017
15
Immunization practices in acute lymphocytic leukemia and post-hematopoietic stem cell transplant in Canadian Pediatric Hematology/Oncology centers. ( 26962702 )
2016
16
Extramedullary Involvement of the Sigmoid Colon with Acute Lymphocytic Leukemia. ( 27189376 )
2016
17
Secondary glioma following acute lymphocytic leukemia: therapeutic implications. ( 27159974 )
2016
18
Novel Approaches for the Interim Management of Relapsed/Refractory Acute Lymphocytic Leukemia: Introduction. ( 27007406 )
2016
19
Allogeneic bone marrow transplantation for therapy-related acute lymphocytic leukemia after autologous hematopoietic stem cell transplantation for multiple myeloma. ( 27473192 )
2016
20
Treating adults with acute lymphocytic leukemia: new pharmacotherapy options. ( 27759440 )
2016
21
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. ( 27301866 )
2016
22
Acute lymphocytic leukemia mimicking spondyloarthritis in an adolescent: A case report and review of the literature. ( 26893708 )
2016
23
B Cell Acute Lymphocytic Leukemia Presenting as a Bile Duct Stricture Diagnosed With Cholangioscopy. ( 27807569 )
2016
24
BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients. ( 27123097 )
2016
25
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia. ( 27328933 )
2016
26
Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia. ( 27599414 )
2016
27
Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors. ( 27094799 )
2016
28
Catheter-related bloodstream infection due to Gordonia sputi in a patient with acute lymphocytic leukemia: a Case Report. ( 26902218 )
2016
29
Potent anti-leukemia activities of chimeric antigen receptor modified T cells against CD19 in Chinese patients with relapsed/refractory acute lymphocytic leukemia. ( 28039267 )
2016
30
Myelodysplastic Syndrome and Acute Lymphocytic Leukemia in Common Variable Immunodeficiency (CVID). ( 26993985 )
2016
31
Multiple unusual lung etiologies in a child with acute lymphocytic leukemia. ( 27616461 )
2016
32
A single black ulcer in a child with acute lymphocytic leukemia. ( 28099607 )
2016
33
Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia. ( 27987364 )
2016
34
Campylobacter jejuni Bacteremia in a Patient With Acute Lymphocytic Leukemia. ( 27621914 )
2016
35
Expression of CD56 is a risk factor for acute lymphocytic leukemia with central nervous system involvement in adults. ( 27734763 )
2016
36
Role of peripheral blood minimum residual disease at day 8 of induction therapy in high-risk pediatric patients with acute lymphocytic leukemia. ( 27526794 )
2016
37
Blinatumomab: A New Treatment for Adults With Relapsed Acute Lymphocytic Leukemia. ( 26991709 )
2016
38
Disseminated Mycobacterium abscessus Complex Infection Manifesting as Multiple Areas of Lymphadenitis and Skin Abscess in the Preclinical Stage of Acute Lymphocytic Leukemia. ( 27374685 )
2016
39
Recurrence of acute lymphocytic leukemia as spinal epidural mass. ( 26778825 )
2016
40
Acute lymphocytic leukemia presenting as a single brain mass. ( 27430416 )
2016
41
Recent advances and novel treatment paradigms in acute lymphocytic leukemia. ( 27695616 )
2016
42
Palifermin and Chlorhexidine Mouthwashes in Prevention of Chemotherapy-Induced Mucositis in Children with Acute Lymphocytic Leukemia: a Randomized Controlled Trial. ( 27942550 )
2016
43
Mechanistic Study of the Phytocompound, 2- I^ -D-Glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne in Human T-Cell Acute Lymphocytic Leukemia Cells by Using Combined Differential Proteomics and Bioinformatics Approaches. ( 26557148 )
2015
44
The clinical potential of inotuzumab ozogamicin in relapsed and refractory acute lymphocytic leukemia. ( 26425338 )
2015
45
Successful Pregnancy and Delivery After Radiation With Ovarian Shielding for Acute Lymphocytic Leukemia Before Menarche. ( 25739028 )
2015
46
Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia. ( 26661660 )
2015
47
Myeloid Antigen-positive T Cell Acute Lymphocytic Leukemia with t(14;18) and Trisomy 10: Report of a Case and Literature Review. ( 26265522 )
2015
48
Acute Lymphocytic Leukemia with Bilateral Renal Masses Masquerading as Nephroblastomatosis. ( 26613060 )
2015
49
Acute Lymphocytic Leukemia in Adults. Pathologic Features and Prognosis. ( 26076558 )
2015
50
L-asparaginase and venous thromboembolism in acute lymphocytic leukemia. ( 26274336 )
2015

Variations for Acute Lymphocytic Leukemia

ClinVar genetic disease variations for Acute Lymphocytic Leukemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NBN NM_002485.4(NBN): c.511A> G (p.Ile171Val) single nucleotide variant risk factor rs61754966 GRCh37 Chromosome 8, 90990521: 90990521
2 ACTB NP_001092.1(ACTB): p.Val209Leu protein only Pathogenic

Expression for Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for Acute Lymphocytic Leukemia

Pathways related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 ACTB CDKN2A CDKN2B NOTCH1 TP53
2 12.36 BCR CDKN2A CDKN2B NOTCH1 RUNX1 TP53
3 11.83 CDKN2A CDKN2B NBN TP53
4
Show member pathways
11.74 BCR CDKN2A RUNX1 TP53
5 11.29 ETV6 PAX5 RUNX1 TLX3 TP53
6 10.64 CDKN2A CDKN2B TP53

GO Terms for Acute Lymphocytic Leukemia

Cellular components related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.85 ACTB CDKN2A NBN NOTCH1 NR3C1 PAX5
2 nucleus GO:0005634 9.8 ACTB CDKN2A CDKN2B ETV6 NBN NOTCH1
3 cytosol GO:0005829 9.53 ACTB ANKS1B ASNS BCR CDKN2A CDKN2B

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 ETV6 NOTCH1 NR3C1 PAX5 TAL1 TP53
2 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.56 NBN TP53
3 hematopoietic stem cell proliferation GO:0071425 9.54 ETV6 RUNX1
4 tetrahydrofolate interconversion GO:0035999 9.52 MTHFR TYMS
5 tetrahydrofolate metabolic process GO:0046653 9.51 MTHFR TYMS
6 regulation of myeloid cell differentiation GO:0045637 9.49 RUNX1 TAL1
7 regulation of B cell receptor signaling pathway GO:0050855 9.48 PAX5 RUNX1
8 somatic stem cell division GO:0048103 9.46 CDKN2A NOTCH1
9 response to amino acid GO:0043200 9.43 ASNS MTHFR TP53
10 response to folic acid GO:0051593 9.4 MTHFR TYMS
11 megakaryocyte differentiation GO:0030219 9.37 CDKN2B TAL1
12 cell cycle arrest GO:0007050 9.35 CDKN2A CDKN2B NBN NOTCH1 TP53
13 replicative senescence GO:0090399 9.33 CDKN2A MME TP53
14 positive regulation of transcription by RNA polymerase II GO:0045944 9.28 CDKN2A CDKN2B ETV6 NOTCH1 NR3C1 PAX5
15 transcription, DNA-templated GO:0006351 10.2 CDKN2A ETV6 NOTCH1 NR3C1 PAX5 RUNX1
16 regulation of transcription, DNA-templated GO:0006355 10.02 CDKN2A ETV6 NOTCH1 NR3C1 PAX5 RUNX1

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.97 CDKN2A ETV6 NR3C1 PAX5 RUNX1 TAL1
2 DNA binding transcription factor activity GO:0003700 9.5 ETV6 NOTCH1 NR3C1 PAX5 RUNX1 TAL1
3 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.46 ETV6 TAL1 TAL2 TP53
4 core promoter binding GO:0001047 9.43 NOTCH1 NR3C1 RUNX1
5 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.37 CDKN2A CDKN2B
6 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.02 ETV6 RUNX1 TAL1 TAL2 TP53

Sources for Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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