ALL
MCID: ACT074
MIFTS: 75

Acute Lymphocytic Leukemia (ALL) malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories
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Summaries for Acute Lymphocytic Leukemia

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Sources:
34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to adult acute lymphocytic leukemia and leukemia. An important gene associated with Acute Lymphocytic Leukemia is BCR (breakpoint cluster region), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and folate polyglutamylation. The compounds ch2h4folate and 5-Methyltetrahydrofolic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin, and related mouse phenotypes are tumorigenesis and normal.

Wikipedia:65 Acute lymphoblastic leukemia (ALL) or acute lymphoid leukemia is an acute form of leukemia, or cancer of... more...

Description from OMIM:47 613067,613065,247640

Aliases & Classifications for Acute Lymphocytic Leukemia

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Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 45Novoseek, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
acute lymphocytic leukemia:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute lymphocytic leukemia 8 43 49 34 31 62
acute lymphoblastic leukemia 8 43 49
leukemia, acute lymphoblastic 9 47
all 43 49
leukemia, acute lymphoblastic, susceptibility to 9
acute lymphoblastic leukemia/lymphoma 49
lymphoblastic leukemia acute 45
leukemia, acute lymphocytic 47


External Ids:

Disease Ontology8 DOID:9952
ICD9CM27 204.0
NCIt40 C3167
ICD10 via Orphanet26 C91.0
ICD1025 C91.0

Related Diseases for Acute Lymphocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 431)
idRelated DiseaseScoreTop Affiliating Genes
1adult acute lymphocytic leukemia31.7CDKN2B, SHMT1, TYMS
2leukemia31.6IKZF1, MTHFR, MTR, BCR, TAL1, CDX2
3wilms tumor31.1MME, CDKN1C
4myelodysplastic syndromes30.8NUP98, CDKN1C, CDKN2B
5non-hodgkin lymphoma30.7PAX5, IKZF1, MTR, BCR, TAL1, CDKN2B
6acute lymphoblastic leukemia, childhood30.7TYMS, MME, IKZF1, MTHFR, BCR, CDKN2B
7burkitt's lymphoma30.6PAX5, CDKN2B
8retinoblastoma30.6ABCG2, TYMS, BCR, CDKN1C, CDKN2B
9myeloma30.5ABCG2, PAX5, BCR, CDKN2B
10lymphoblastic lymphoma30.5PAX5, TAL1, CDKN2B
11chronic myeloid leukemia30.4NUP98, IKZF1, BCR, TAL1, CDKN1C, CDKN2B
12astrocytoma30.4PAX5, BCR, CDKN1C, CDKN2B
13leukemia, acute lymphoblastic 330.4CDKN2B, BCR, MME, PAX5
14chronic lymphocytic leukemia30.4CDKN2B, BCR, PAX5
15vitamin b12 deficiency30.3MTR, MTHFR
16esophagitis30.3CDX1, CDX2
17b-cell lymphomas30.3ABCG2, PAX5, MME, IKZF1, BCR, CDKN1C
18acute leukemia30.3ABCG2, NUP98, PAX5, MTHFR, BCR, TAL1
19b-cell chronic lymphocytic leukemia30.3MME, PAX5
20precursor t-cell acute lymphoblastic leukemia30.2TYMS, NUP98, PAX5, IKZF1, BCR, TAL1
21follicular lymphoma30.2PAX5, MME, BCR, CDKN1C
22adenoma30.1CDX1, CDKN1C, CDX2, MTR, MTHFR
23t-cell leukemia30.1TAL1, IKZF1, TYMS
24breast cancer30.0ABCG2, TYMS, SHMT1, MME, MTHFR, MTR
25pre-b-cell acute lymphoblastic leukemia10.9
26hemophagocytic lymphohistiocytosis10.6
27hypertriglyceridemia10.6
28fusariosis10.5
29obesity10.5
30pancreatitis10.5
31noonan syndrome10.5
32hyperphosphatemia10.5
33acute t cell leukemia10.5
34arthritis10.5
35influenza10.5
36ataxia10.5
37myeloid leukemia10.5
38hyperglycemia10.4
39hematopoietic stem cell transplantation10.4
40hypoglycemia10.4
41severe congenital neutropenia10.4
42pancytopenia10.4
43aleukemic leukemia cutis10.4
44lactic acidosis10.4
45chronic myelomonocytic leukemia10.4
46growth hormone deficiency10.4
47zygomycosis10.4
48eosinophilia10.4
49histiocytosis10.4
50meningitis10.4

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to acute lymphocytic leukemia

Symptoms for Acute Lymphocytic Leukemia

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Sources:
47OMIM
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Clinical features from OMIM:

613067,613065,247640

Drugs & Therapeutics for Acute Lymphocytic Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Lymphocytic Leukemia

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Lymphocytic Leukemia

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Anatomical Context for Acute Lymphocytic Leukemia

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

33
Bone, Bone marrow, Skin, Testes, T cells, B cells, Myeloid, Liver, Thyroid, Breast, Brain, Kidney, Prostate, Monocytes, Spleen, Endothelial, Pineal

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Acute Lymphocytic Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

37 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5TCF3, IKZF1, CDX2, SHMT1, CDKN2B
2MP:00028739.2CDKN1C, BCR, CDX2, CDX1, PAX5, TCF3
3MP:00053709.1SHMT1, MME, IKZF1, BCR, ABCG2
4MP:00107719.0ABCG2, MME, TCF3, IKZF1, MTHFR, TAL1
5MP:00053849.0BCR, CDKN2B, CDKN1C, CDX2, TAL1, IKZF1
6MP:00053909.0TAL1, CDKN1C, CDX2, MTHFR, PAX5, CDX1
7MP:00053808.7TCF3, TAL1, CDX2, CDKN1C, CDX1, NUP98
8MP:00036318.6CDKN1C, BCR, MTHFR, ABCG2, TCF3, PAX5
9MP:00053878.3CDKN2B, CDKN1C, TAL1, BCR, TCF3, MME
10MP:00053787.9NUP98, CDKN1C, CDX2, TAL1, TAL2, BCR
11MP:00053977.5CDKN2B, IKZF1, BCR, TAL2, TAL1, CDKN1C
12MP:00053767.5CDKN2B, CDKN1C, CDX2, TAL2, SHMT1, MME
13MP:00107687.4CDX2, TAL2, PAX5, TCF3, IKZF1, MTR

Publications for Acute Lymphocytic Leukemia

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52PubMed
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Articles related to Acute Lymphocytic Leukemia:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia. (23633004)
2013
2
Cavernous malformations of the brain after treatment for acute lymphocytic leukemia: presentation and long-term follow-up. (23215773)
2013
3
Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice. (23301070)
2013
4
Native kidney BK virus nephropathy associated with acute lymphocytic leukemia. (23443506)
2013
5
Acute lymphocytic leukemia presented as back pain and revealed by bone scintigraphy. (23640214)
2013
6
Human leukocyte antigen (HLA)-DRB1*14 is associated with a high incidence of acute lymphocytic leukemia. (22868506)
2012
7
Exposure to magnetic fields and childhood acute lymphocytic leukemia in SALo Paulo, Brazil. (21840286)
2011
8
Inhibition of histone deacetylase 6 as a therapeutic strategy for acute lymphocytic leukemia. (21657957)
2011
9
Bilateral numb chin syndrome leading to a diagnosis of Burkitt's cell acute lymphocytic leukemia: a case report and literature review. (21215664)
2011
10
Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906. (21360654)
2011
11
B cell acute lymphocytic leukemia in pregnancy. (20717686)
2011
12
A rare initial manifestation of acute lymphocytic leukemia: bilaterally enlarged kidneys and liver. (19721300)
2009
13
Detection of human cyclin C gene expression in childhood acute lymphocytic leukemia using real-time fluorescence quantitative PCR]. (18289462)
2008
14
Outcome of adults with acute lymphocytic leukemia after second salvage therapy. (18846563)
2008
15
Philadelphia chromosome positive acute lymphocytic leukemia: a new era of challenges. (18024662)
2007
16
Acute lymphocytic leukemia in sporadic neurofibromatosis. (17675741)
2007
17
Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia. (17170503)
2006
18
Electrolyte abnormalities at diagnosis of acute lymphocytic leukemia may be a clue for renal damage in long-term period. (15838391)
2005
19
Outcomes of unrelated cord blood transplants and allogeneic-related hematopoietic stem cell transplants in children with high-risk acute lymphocytic leukemia. (15361908)
2004
20
Cutaneous mucormycosis during induction chemotherapy for acute lymphocytic leukemia. (15061222)
2004
21
Acute lymphocytic leukemia after fulminant varicella associated with severe neutropenia. (12940335)
2003
22
Methotrexate infusions as central nervous system prophylaxis in children with acute lymphocytic leukemia: the Norwegian experience. (12637215)
2003
23
Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. (14559839)
2003
24
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. (11986237)
2002
25
Comparison of two different schedules of granulocyte-colony-stimulating factor during treatment for acute lymphocytic leukemia with a hyper-CVAD (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) regimen. (11900213)
2002
26
Immunophenotypic analysis of acute lymphocytic leukemia. (12094473)
2002
27
Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes. Correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia. (11726315)
2001
28
Cytogenetic aberrations in adult acute lymphocytic leukemia: optimal technique may influence the results. (11454422)
2001
29
Ph-positive acute lymphocytic leukemia in a man with Klinefelter syndrome. (10766521)
2000
30
The hyper-CVAD regimen in adult acute lymphocytic leukemia. (11147229)
2000
31
Deletions and losses in chromosomes 5 or 7 in adult acute lymphocytic leukemia: incidence, associations and implications. (10360374)
1999
32
Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia. (9619913)
1998
33
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. (9028333)
1997
34
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. (9305617)
1997
35
Leukocyte glucose 6 phosphate dehydrogenase (G6PD) as prognostic indicator in children with acute lymphocytic leukemia. (8786155)
1995
36
p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia. (7780130)
1995
37
The role of bone marrow transplantation in adult acute lymphocytic leukemia. (8338797)
1993
38
From the Centers for Disease Control and Prevention. Change in source of information: availability of varicella vaccine for children with acute lymphocytic leukemia. (8315766)
1993
39
Chemotherapy-related side effects in children with acute lymphocytic leukemia in Taiwan: a nursing perspective. (1514401)
1992
40
Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia. (1381235)
1992
41
Results of the vincristine, doxorubicin, and dexamethasone regimen in adults with standard- and high-risk acute lymphocytic leukemia. (2189958)
1990
42
Successful use of granulocyte-macrophage colony-stimulating factor in patients with acute lymphocytic leukemia. (2203265)
1990
43
Deletion of alpha-, beta-, and omega-interferon genes in malignant cells from children with acute lymphocytic leukemia. (1701354)
1990
44
Improved prognosis for childhood acute lymphocytic leukemia with very high white blood cell count (greater than 100/nl) with rotation of non-cross-resistant drug combinations. (2182442)
1990
45
Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. (2114933)
1990
46
Mitoxantrone and high-dose cytosine arabinoside for the treatment of refractory acute lymphocytic leukemia. (2293869)
1990
47
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. (2323651)
1990
48
Acute lymphocytic leukemia treatment: effects on learning. (2778595)
1989
49
A comparison of two regimens for high-risk acute lymphocytic leukemia in childhood. A Pediatric Oncology Group Study. (2910421)
1989
50
Testicular relapse in adult acute lymphocytic leukemia: a case report and literature review. (2649778)
1989

Variations for Acute Lymphocytic Leukemia

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Acute Lymphocytic Leukemia:

64
id Symbol AA change Variation ID SNP ID
1PAX5p.Gly183SerVAR_070682
2PAX5p.Gly183SerVAR_070682

Clinvar genetic disease variations for Acute Lymphocytic Leukemia:

1
id Gene Name Type Significance SNP ID Assembly Location
1FLT3NM_004119.2(FLT3): c.2504A> T (p.Asp835Val)single nucleotide variantPathogenicrs121909646GRCh37Chr 13, 28592641: 28592641
2FLT3NM_004119.2(FLT3): c.2503G> T (p.Asp835Tyr)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
3FLT3FLT3, 3-BP DEL, NT1777deletionPathogenic
4NBNNM_002485.4(NBN): c.511A> G (p.Ile171Val)single nucleotide variantPathogenic, Uncertain significance, risk factorrs61754966GRCh37Chr 8, 90990521: 90990521

Expression for genes affiliated with Acute Lymphocytic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 5Cell Signaling Technology, 60Thomson Reuters
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Pathways related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0BCR, ABCG2
2
Show member pathways
Glycine Metabolism38
glycine biosynthesis I38
folate transformations38
9.9SHMT1, MTR
3
Show member pathways
9.8CDKN2B, CDKN1C, TYMS
4
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.6MTR, MTHFR, SHMT1
5
Show member pathways
flavin biosynthesis IV (mammalian)38
molybdenum cofactor biosynthesis38
coenzyme A biosynthesis38
thiamin salvage III38
alanine biosynthesis III38
thio-molybdenum cofactor biosynthesis38
biotin-carboxyl carrier protein assembly38
9.6MTHFR, MTR, SHMT1
6
Show member pathways
9.6MTHFR, ABCG2, TYMS
79.6MME, TAL1, TCF3, PAX5, IKZF1
8
Show member pathways
One Carbon Metabolism38
dTMP de novo biosynthesis (mitochondrial)38
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate38
Trans-sulfuration and one carbon metabolism38
methionine salvage38
Methionine metabolism60
9.4SHMT1, TYMS, MTHFR, MTR
98.8MTR, NUP98, SHMT1, MTHFR, CDKN2B, BCR

Compounds for genes affiliated with Acute Lymphocytic Leukemia

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45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1ch2h4folate4510.3MTHFR, TYMS
25-Methyltetrahydrofolic acid2410.3MTHFR, MTR
3methyl-group4510.3MTR, MTHFR
4pemetrexed51 1111.2MTHFR, TYMS
59-aminocamptothecin4510.2ABCG2, TYMS
65,10-methenyltetrahydrofolate4510.2MTHFR, MTR
7dactinomycin51 1111.2ABCG2, MTR
8adenosylcobalamin45 2411.2MTHFR, MTR
9methylcobalamin45 2411.1MTHFR, MTR
10nilotinib51 1111.1ABCG2, BCR
115,10-Methylene-THF2410.1MTHFR, SHMT1, TYMS
12probenecid29 45 61 51 1114.1PAX5, TYMS, ABCG2
13cyanocobalamin51 24 1112.1MTR, MTHFR
14hydroxocobalamin45 1111.1MTHFR, MTR
15leucovorin45 51 1112.1SHMT1, TYMS, MTHFR
16Tetrahydrofolic acid24 1111.0MTR, MTHFR, SHMT1
1710-formyltetrahydrofolate4510.0MTHFR, MTR
18thiopurine4510.0MTHFR, ABCG2, TYMS
19taxane4510.0MTHFR, TYMS, ABCG2
20vitamin b12459.9MTHFR, TYMS, MTR
21oxaliplatin45 51 1111.9TYMS, MTHFR, ABCG2
225-methyltetrahydrofolate45 1110.9MTR, MTHFR
235-aza-2deoxycytidine459.8CDKN1C, CDX1, CDKN2B, CDX2
24b vitamins459.8TYMS, SHMT1, MTHFR, MTR
25tetrahydrofolate459.8SHMT1, MTR, MTHFR, TYMS
26vitamin b6459.8MTHFR, MTR, TYMS, SHMT1
27pyridoxal 5-phosphate459.8MTR, SHMT1, TYMS, MTHFR
28carboplatin45 51 1111.8ABCG2, TYMS, MTHFR
29purine45 2410.8MTHFR, SHMT1, MTR, TYMS
30thymidylate459.8MTHFR, MTR, TYMS, SHMT1
31fluorouracil51 1110.8MTHFR, SHMT1, ABCG2, TYMS
32irinotecan45 51 1111.8ABCG2, MTHFR, SHMT1, TYMS
33benazepril45 51 1111.8MTR, MTHFR
34cytarabine45 51 1111.8CDKN2B, TYMS, ABCG2, BCR, MME
35cyclophosphamide45 51 1111.7BCR, MTR, MTHFR, ABCG2
36methionine459.7MTR, SHMT1, MME, MTHFR
37gemcitabine45 51 1111.7ABCG2, TYMS, MTHFR
38thymidine45 2410.6MME, TYMS, MTHFR, CDX2, BCR
39bevacizumab51 1110.6MTHFR, SHMT1
40homocysteine45 2410.6MTR, MTHFR, SHMT1
41creatinine459.6MTR, MME, MTHFR, PAX5, TYMS
42cholesterol45 29 24 1112.5PAX5, CDKN1C, BCR, MTHFR, ABCG2
43doxorubicin45 51 1111.4MME, TYMS, MTR, ABCG2
44folate459.3MTR, IKZF1, MTHFR, ABCG2, SHMT1, TYMS
45cysteine459.3CDX2, BCR, MTR, MTHFR, MME, TYMS
46dihydrofolate459.3MTR, CDKN2B, MTHFR, SHMT1, TYMS, ABCG2
47methotrexate51 45 1111.3MTHFR, SHMT1, TYMS, MTR, ABCG2, CDKN2B
48oligonucleotide459.3PAX5, CDX2, BCR, ABCG2, NUP98, TAL1
49estrogen459.2CDKN2B, CDX2, MTHFR, MME, ABCG2, MTR
50serine458.9PAX5, CDKN2B, TAL1, TYMS, BCR, MTR

GO Terms for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
16Gene Ontology
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Cellular components related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.3TYMS, SHMT1, PAX5, TCF3, IKZF1, TAL1
2cytosolGO:0058297.8TYMS, NUP98, SHMT1, GIMAP4, MTHFR, MTR

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1Peyers patch developmentGO:04854110.4IKZF1, TCF3
2megakaryocyte differentiationGO:03021910.3CDKN2B, TAL1
3natural killer cell differentiationGO:00177910.2IKZF1, TCF3
4tetrahydrofolate interconversionGO:03599910.2SHMT1, MTHFR
5folic acid metabolic processGO:04665510.1MTHFR, SHMT1
6negative regulation of protein serine/threonine kinase activityGO:07190110.1CDKN2B, CDKN1C
7response to folic acidGO:05159310.1MTHFR, TYMS
8organ morphogenesisGO:0098879.9CDX1, CDX2, PAX5
9negative regulation of phosphorylationGO:0423269.9CDKN1C, CDKN2B
10water-soluble vitamin metabolic processGO:0067679.9MTHFR, MTR, SHMT1
11vitamin metabolic processGO:0067669.9SHMT1, MTHFR, MTR
12positive regulation of transforming growth factor beta receptor signaling pathwayGO:0305119.7CDKN2B, CDKN1C
13negative regulation of transcription from RNA polymerase II promoterGO:0001229.7CDKN1C, PAX5, CDX2, TAL1, IKZF1
14response to drugGO:0424939.6ABCG2, TYMS, TCF3, MTHFR
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.6CDX1, IKZF1, TCF3, PAX5, TAL1, CDKN2B
16positive regulation of transcription, DNA-templatedGO:0458939.6CDKN1C, CDX2, TAL1, TCF3
17small molecule metabolic processGO:0442818.6TYMS, MTR, MTHFR, SHMT1, NUP98, ABCG2

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:07088810.1TAL1, TCF3
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.1CDKN2B, CDKN1C
3RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.0CDX1, TAL1
4peptide bindingGO:0422779.5MME, NUP98
5sequence-specific DNA binding transcription factor activityGO:0037009.4PAX5, TCF3, IKZF1, TAL1, CDX2

Products for genes affiliated with Acute Lymphocytic Leukemia

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  • Antibodies
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Sources for Acute Lymphocytic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet