ALL
MCID: ACT074
MIFTS: 77

Acute Lymphocytic Leukemia (ALL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Acute Lymphocytic Leukemia

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to acute leukemia and leukemia. An important gene associated with Acute Lymphocytic Leukemia is BCR (breakpoint cluster region), and among its related pathways are Lymphocyte Signaling and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds dihydrofolate and b vitamins have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related mouse phenotypes are mortality/aging and hematopoietic system.

Wikipedia:63 Acute lymphoblastic leukemia (ALL) is a form of leukemia, or cancer of the white blood cells... more...

Description from OMIM:46 613065,613067,247640

Aliases & Classifications for Acute Lymphocytic Leukemia

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 44Novoseek, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acute lymphocytic leukemia:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute lymphocytic leukemia 8 42 48 33 30 60
acute lymphoblastic leukemia 8 42 48
leukemia, acute lymphoblastic 9 46
all 42 48
leukemia, acute lymphoblastic, susceptibility to 9
acute lymphoblastic leukemia/lymphoma 48
lymphoblastic leukemia acute 44
leukemia, acute lymphocytic 46


External Ids:

Disease Ontology8 DOID:9952
NCIt39 C3167
ICD9CM27 204.0
ICD10 via Orphanet26 C91.0
ICD1025 C91.0

Related Diseases for Acute Lymphocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute Lymphocytic Leukemia family:

Adult Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia
Familial Acute Lymphocytic Leukemia Familial Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 3
Leukemia, Acute Lymphocytic 1 Leukemia, Chronic Lymphocytic 1
Leukemia, Chronic Lymphocytic 5 Leukemia, Chronic Lymphocytic 2

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1419)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.1NUP98, TAL1, PAX5, BCR, MTHFR, CDKN2B
2leukemia32.1TAL1, MTHFR, MTR, ANKS1B, TYMS, NUP98
3adult acute lymphocytic leukemia31.6SHMT1, TYMS, CDKN2B
4myeloid leukemia30.8CDKN2B, NUP98, BCR
5non-hodgkin lymphoma30.7PAX5, BCR, CDKN2B, MTR, IKZF1, TAL1
6acute lymphoblastic leukemia, childhood30.7BCR, MME, IKZF1, CDKN2B, MTHFR, TYMS
7burkitt's lymphoma30.6MME, PAX5, BCR
8retinoblastoma30.5TYMS, CDKN2B, BCR, CDKN1C
9rheumatoid arthritis30.5MME, MTHFR
10myeloma30.4CDKN2B, PAX5, BCR
11chronic myeloid leukemia30.4BCR, TAL1, IKZF1, CDKN1C, CDKN2B, NUP98
12precursor b-cell acute lymphoblastic leukemia30.3MME, CDKN2B, PAX5, BCR
13precursor t-cell acute lymphoblastic leukemia30.3TYMS, NUP98, BCR, PAX5, IKZF1, CDKN2B
14prostate cancer30.3MME, BCR, CDKN2B, CDX2
15hepatocellular carcinoma30.2CDKN2B, CDX2, MME, BCR, CDKN1C
16melanoma30.1CDKN2B, MME, CDX2
17lung cancer30.1TYMS
18esophagitis30.1CDX2, CDX1
19osteosarcoma30.1TYMS
20adenoma30.1CDKN1C, CDX2, CDX1, MTR, MTHFR
21breast cancer30.1SHMT1, CDKN1C, CDX2, MTHFR, MTR, MME
22glioblastoma multiforme30.1CDKN1C, CDKN2B
23down syndrome30.1MTR, MTHFR
24meningioma30.1CDKN2B
25adenocarcinoma30.1MME, CDX2, CDX1, CDKN1C, TYMS
26pancreatic cancer30.1CDKN1C, CDX2, TYMS
27colorectal cancer29.9MTHFR, SHMT1, TYMS, CDX2, MTR, CDKN1C
28colon cancer29.8MTHFR, MTR, CDX1, CDKN2B, CDX2, TYMS
29ovarian cancer29.8TYMS, MME
30spina bifida29.8MTHFR, MTR
31malignant mesothelioma29.8TYMS, CDKN2B
32migraine29.7MTHFR
33cholangiocarcinoma29.6CDX2, MME
34gallbladder cancer29.6TYMS, CDX2
35bladder carcinoma29.4TYMS
36hematologic cancer29.4PAX5, BCR, CDKN1C, CDKN2B, NUP98, IKZF1
37childhood leukemia11.0
38acute t cell leukemia10.8
39t-cell leukemia10.8
40chronic lymphocytic leukemia10.6
41hemophagocytic lymphohistiocytosis10.6
42acute myeloid leukemia10.5
43acute pancreatitis10.5
44fusariosis10.5
45obesity10.5
46pancreatitis10.5
47central nervous system leukemia10.5
48noonan syndrome10.5
49hyperphosphatemia10.5
50arthritis10.5

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to acute lymphocytic leukemia

Clinical Features for Acute Lymphocytic Leukemia

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

613065,613067,247640

Drugs & Therapeutics for Acute Lymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Lymphocytic Leukemia

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Search CenterWatch for Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Lymphocytic Leukemia

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Anatomical Context for Acute Lymphocytic Leukemia

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

32
Bone, Bone marrow, T cells, B cells, Skin, Testes, Myeloid, Liver, Monocytes, Thyroid, Breast, Kidney, Brain, Prostate, Spleen, Whole blood, Endothelial, Pineal

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Acute Lymphocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.8HOXD4, CDKN2B, BCR, PAX5, CDX2, TCF3
2MP:000539710.7IKZF1, CDKN1C, CDX1, CDKN2B, NUP98, TAL2
3MP:000537810.7IKZF1, BCR, PAX5, TCF3, TAL1, TAL2
4MP:000538710.6TAL1, IKZF1, CDKN1C, CDKN2B, NUP98, GIMAP4
5MP:000538410.6IKZF1, NUP98, CDKN2B, CDX2, CDKN1C, TAL1
6MP:000537610.5SHMT1, BCR, TCF3, MME, TAL1, TAL2
7MP:000539010.2CDX2, CDKN1C, CDX1, PAX5, TAL1, HOXD4

Publications for Acute Lymphocytic Leukemia

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Sources:
50PubMed
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Articles related to Acute Lymphocytic Leukemia:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Intentional donor lymphocyte induced limited acute graft versus host disease is essential for long-term survival of relapsed acute myeloid leukemia after allogeneic stem cell transplantation. (24241493)
2013
2
Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737. (23723123)
2013
3
Therapy-related acute myeloid leukemia in a patient with chronic lymphocytic leukemia treated with rituximab-bendamustine. (23907409)
2013
4
The indicative effect of Notch1 expression for the prognosis of T-cell acute lymphocytic leukemia: a systematic review. (22311010)
2012
5
Vascular endothelial growth factor-C and its receptor type-3 expressed in acute lymphocytic leukemia cases with t(1;19). (21732038)
2011
6
Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease. (20146989)
2010
7
Treatment of Philadelphia-positive acute lymphocytic leukemia with tyrosine kinase inhibitors: What is the optimal regimen? (20131307)
2010
8
Transient hyperglycemia during childhood acute lymphocytic leukemia chemotherapy: an old event revisited. (19701154)
2009
9
Orbital meningioma after cranial radiation for acute lymphocytic leukemia. (18716974)
2008
10
Study of the correlation between the expression level of asparagine synthetase and the outcome of children with acute lymphocytic leukemia]. (19035175)
2008
11
Successful high-dose methotrexate chemotherapy in a patient with acute lymphocytic leukemia who developed acute renal failure during the initial treatment. (18045317)
2007
12
Indoleamine 2, 3-dioxygenase expression in cells of human acute monocyte leukemia (M(5)) and acute lymphocyte leukemia and therapeutic effect of its inhibitor 1-methyl tryptophan. (17605849)
2007
13
Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia. (17170503)
2006
14
Analysis of genetic alterations and clonal proliferation in children treated for acute lymphocytic leukemia. (16951156)
2006
15
Induction of autologous CD4- and CD8-mediated T-cell responses against acute lymphocytic leukemia cell line using apoptotic tumor cell-loaded dendritic cells. (16459188)
2006
16
Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia. (15978938)
2005
17
Treatment outcome of adult acute lymphocytic leukemia with VPD(L) regimen: analysis of prognostic factors. (12760264)
2003
18
Acute lymphocytic leukemia CNS disease presenting as central diabetes insipidus. (12038668)
2002
19
Leukodepletion for acute lymphocytic leukemia in a three-week-old infant. (11309829)
2001
20
Acute myelogenous leukemia blasts as accessory cells during in vitro T lymphocyte activation. (11161436)
2000
21
Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia. (10905060)
2000
22
Hepatic and small bowel mucormycosis after chemotherapy in a patient with acute lymphocytic leukemia. (10895981)
2000
23
A comparative pharmacokinetic study of doxorubicin and 4'-epi-doxorubicin in children with acute lymphocytic leukemia using a limited sampling procedure. (10789596)
2000
24
Hemolytic-uremic syndrome as a presenting form of acute lymphocytic leukemia. (10985366)
2000
25
CD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. (10411928)
1999
26
Effect of high-dose methylprednisolone and G-CSF treatments on lymphocyte subtypes in neutropenic children with acute lymphoblastic leukemia: a pilot study. (9842648)
1998
27
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. (9028333)
1997
28
Analysis of the BCR-ABL protein in Philadelphia chromosome-positive adult acute lymphocytic leukemia. (9305617)
1997
29
Biology and treatment of acute lymphocytic leukemia in children. (9045307)
1997
30
Acute lymphocytic leukemia: nursing care, psychosocial issues, and discharge education. (9297182)
1997
31
Sporadic acute lymphocytic leukemia arising in a patient with neurofibromatosis and xanthogranulomatosis. (8597895)
1996
32
Growth and biologic properties of karyotypically defined subcategories of adult acute lymphocytic leukemia in mice with severe combined immunodeficiency. (7492788)
1995
33
V-J junctional sequences of T cell receptor gamma gene in acute lymphocytic leukemia. (7755873)
1995
34
Traditional Chinese medicines improve the course of refractory leukemic lymphoblastic lymphoma and acute lymphocytic leukemia: two case reports. (7572781)
1995
35
Acute lymphocytic leukemia with dermatomyositis-like onset in childhood. (8371239)
1993
36
Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes. (1351762)
1992
37
Prognostic significance of elevated serum beta 2-microglobulin levels in adult acute lymphocytic leukemia. (1466355)
1992
38
Individualized dosages of chemotherapy as a strategy to improve response for acute lymphocytic leukemia. (1780747)
1991
39
Hypoplastic anemia: a preleukemic state in acute lymphocytic leukemia. (1797672)
1991
40
Clinical application of thymidine kinase activity in patients with acute non-lymphocytic leukemia]. (1987902)
1991
41
Successful use of granulocyte-macrophage colony-stimulating factor in patients with acute lymphocytic leukemia. (2203265)
1990
42
Improved prognosis for childhood acute lymphocytic leukemia with very high white blood cell count (greater than 100/nl) with rotation of non-cross-resistant drug combinations. (2182442)
1990
43
Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia. (2114933)
1990
44
In vitro and in vivo properties of human/mouse chimeric monoclonal antibody specific for common acute lymphocytic leukemia antigen. (2348236)
1990
45
Breast involvement with acute lymphocytic leukemia. (2924269)
1989
46
B-cell acute lymphocytic leukemia in HIV-antibody-positive patients. (2816914)
1989
47
Characterisation of enkephalinase (EC 3.4.24.11) activity on various leukemic cells expressing the common acute lymphocytic leukemia antigen (CALLA). (2524403)
1989
48
Experience with vincristine, doxorubicin, and dexamethasone (VAD) chemotherapy in adults with refractory acute lymphocytic leukemia. (2659160)
1989
49
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. (3052630)
1988
50
Therapy of adult acute lymphocytic leukemia. (6594761)
1984

Genetic Variations for Acute Lymphocytic Leukemia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute Lymphocytic Leukemia:

62
id Symbol AA change Variation ID SNP ID
1PAX5p.Gly183SerVAR_070682
2PAX5p.Gly183SerVAR_070682

Expression for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
4Cell Signaling Technology, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1dihydrofolate4410.9SHMT1, TYMS, MTR, MTHFR, CDKN2B
2b vitamins4410.9MTHFR, SHMT1, TYMS, MTR
3folate4410.9MTR, SHMT1, TYMS, IKZF1, MTHFR
4tetrahydrofolate4410.9TYMS, MTR, MTHFR, SHMT1
5vitamin b64410.9SHMT1, TYMS, MTR, MTHFR
6pyridoxal 5-phosphate4410.9MTHFR, MTR, SHMT1, TYMS
7methotrexate44 49 1112.9TYMS, CDKN2B, MTHFR, MTR, SHMT1
8serine4410.9CDKN2B, TAL1, BCR
9cytarabine44 49 1112.9BCR, CDKN2B, TYMS, MME
10Tetrahydrofolic acid11 2411.9MTHFR, SHMT1, MTR
11purine44 2411.9TYMS, SHMT1, MTR, MTHFR
12thymidine44 2411.9MME, CDX2, BCR, TYMS, MTHFR
13thymidylate4410.9MTHFR, MTR, SHMT1, TYMS
145-aza-2deoxycytidine4410.9CDKN1C, CDX2, CDX1, CDKN2B
15methyl-group4410.9MTHFR, MTR
16ch2h4folate4410.8MTHFR, TYMS
17creatinine4410.8PAX5, TYMS, MME
185,10-methenyltetrahydrofolate4410.8MTHFR, MTR
19adenosylcobalamin44 2411.8MTR, MTHFR
20vitamin b124410.8MTR, TYMS, MTHFR
21methylcobalamin44 2411.8MTHFR, MTR
22pemetrexed49 1111.8MTHFR, TYMS
23retinoic acid44 2411.8MTHFR, CDKN2B, HOXD4, TAL1, MME, CDX1
2410-formyltetrahydrofolate4410.8MTHFR, MTR
25cyanocobalamin49 11 2412.8MTHFR, MTR
26hydroxocobalamin44 1111.7MTR, MTHFR
27methionine4410.7MTR, MME, MTHFR, SHMT1
28cysteine4410.7MTHFR, TYMS, CDX2, MME, BCR, MTR
295-methyltetrahydrofolate44 1111.7MTHFR, MTR
30betaine44 2411.6MTR, MTHFR
31homocysteine44 2411.6MTHFR, MTR, SHMT1
32oligonucleotide4410.6NUP98, CDX2, TAL1, PAX5, BCR
33risedronate44 59 49 28 1114.5TYMS, PAX5
34cystathionine4410.5MTR, MTHFR
35capecitabine44 49 1112.4MTHFR, TYMS
36methylmalonic acid44 2411.2MTR, MTHFR

GO Terms for genes affiliated with Acute Lymphocytic Leukemia

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Sources:
16Gene Ontology
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Cellular components related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.6PAX5, TYMS, GIMAP4, CDKN2B, CDX1, CDKN1C

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594410.8TCF3, CDKN2B, CDX1, IKZF1, TAL1, PAX5
2tetrahydrofolate interconversionGO:03599910.7SHMT1, MTHFR
3megakaryocyte differentiationGO:03021910.7CDKN2B, TAL1
4Peyers patch developmentGO:04854110.7IKZF1, TCF3
5folic acid metabolic processGO:04665510.6MTHFR, SHMT1
6water-soluble vitamin metabolic processGO:00676710.6MTHFR, SHMT1, MTR
7negative regulation of transcription from RNA polymerase II promoterGO:00012210.6TAL1, IKZF1, CDKN1C, CDX2, PAX5
8vitamin metabolic processGO:00676610.5SHMT1, MTHFR, MTR
9negative regulation of phosphorylationGO:04232610.5CDKN1C, CDKN2B
10organ morphogenesisGO:00988710.4CDX1, CDX2, PAX5
11natural killer cell differentiationGO:00177910.2TCF3, IKZF1

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.5CDX1, TAL1
2sequence-specific DNA binding transcription factor activityGO:00370010.5IKZF1, PAX5, TCF3, TAL1, CDX2, HOXD4
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1C, CDKN2B

Products for genes affiliated with Acute Lymphocytic Leukemia

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  • Antibodies
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  • Lysates
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Sources for Acute Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet