ALL
MCID: ACT074
MIFTS: 69

Acute Lymphocytic Leukemia (ALL) malady

Cancer, Blood, Immune categories

Summaries for Acute Lymphocytic Leukemia

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute lymphocytic leukemia (all), also called acute lymphoblastic leukemia, there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. all is the most common type of cancer in children. possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70. symptoms of all include: weakness or feeling tired fever easy bruising or bleeding bleeding under the skin shortness of breath weight loss or loss of appetite pain in the bones or stomach pain or a feeling of fullness below the ribs painless lumps in the neck, underarm, stomach, or groin tests that examine the blood and bone marrow diagnose all. treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Lymphocytic Leukemia, also known as acute lymphoblastic leukemia, is related to acute lymphoblastic leukemia, childhood and acute leukemia. An important gene associated with Acute Lymphocytic Leukemia is BCR (breakpoint cluster region), and among its related pathways are Lymphocyte Signaling and One Carbon Metabolism. The compounds dihydrofolate and b vitamins have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Wikipedia:64 Acute lymphoblastic leukemia (ALL) is a form of leukemia, or cancer of the white blood cells... more...

Description from OMIM:47 613065,613067,247640

Aliases & Classifications for Acute Lymphocytic Leukemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 9diseasecard, 47OMIM, 45Novoseek, 40NCIt, 57SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
acute lymphocytic leukemia:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute lymphocytic leukemia 8 43 49 34 31 61
acute lymphoblastic leukemia 8 43 49
leukemia, acute lymphoblastic 9 47
all 43 49
leukemia, acute lymphoblastic, susceptibility to 9
acute lymphoblastic leukemia/lymphoma 49
lymphoblastic leukemia acute 45
leukemia, acute lymphocytic 47


External Ids:

Disease Ontology8 DOID:9952
NCIt40 C3167
ICD9CM27 204.0
ICD10 via Orphanet26 C91.0
ICD1025 C91.0

Related Diseases for Acute Lymphocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1346)
idRelated DiseaseScoreTop Affiliating Genes
1acute lymphoblastic leukemia, childhood32.2MTHFR, TYMS, CDKN2B, IKZF1, MME, BCR
2acute leukemia32.2MTHFR, NUP98, CDKN2B, TAL1, BCR
3adult acute lymphocytic leukemia31.6SHMT1, TYMS, CDKN2B
4wilms tumor30.9MME, CDKN1C
5burkitt's lymphoma30.6MTR, SHMT1, TYMS, CDKN2B, CDKN1C, IKZF1
6chronic myeloid leukemia30.5NUP98, CDKN2B, CDKN1C, IKZF1, TAL1, BCR
7precursor b-cell acute lymphoblastic leukemia30.3BCR, MME, CDKN2B
8precursor t-cell acute lymphoblastic leukemia30.3TYMS, NUP98, CDKN2B, IKZF1, TAL1, BCR
9follicular lymphoma30.2CDKN1C, MME, BCR
10adenocarcinoma30.1TYMS, CDX1, CDX2, CDKN1C, MME
11adenoma30.1MTHFR, MTR, CDX1, CDX2, CDKN1C
12down syndrome30.1MTHFR, MTR
13colorectal cancer30.0MTHFR, MTR, SHMT1, TYMS, CDX1, CDX2
14spina bifida29.8MTHFR, MTR
15neural tube defects29.7MTHFR, MTR, SHMT1, TYMS
16bladder carcinoma29.4TYMS
17lymphoma, diffuse large cell29.4CDKN2B, MME
18anencephaly29.4MTHFR
19acute t cell leukemia10.9
20t-cell leukemia10.9
21lymphocytic leukemia, acute t-cell10.9
22pre-b-cell acute lymphoblastic leukemia10.8
23leukemia, acute pre-b-cell10.8
24leukemia, acute lymphoblastic 210.8
25acute promyelocytic leukemia10.7
26leukemia/lymphoma, t-cell10.7
27acute non lymphoblastic leukemia10.7
28hemophagocytic lymphohistiocytosis10.6
29hypertriglyceridemia10.5
30acute myeloid leukemia10.5
31t-cell adult acute lymphocytic leukemia10.5
32fusariosis10.5
33central nervous system leukemia10.5
34adult t-cell leukemia10.5
35leukemia, acute lymphocytic 110.5
36acute pancreatitis10.5
37noonan syndrome10.5
38hyperphosphatemia10.5
39arthritis10.5
40chronic myelomonocytic leukemia10.5
41ataxia10.5
42familial acute lymphocytic leukemia10.4
43precursor b lymphoblastic lymphoma/leukemia10.4
44severe congenital neutropenia10.4
45pancytopenia10.4
46null-cell leukemia10.4
47hypoglycemia10.4
48measles10.4
49pediatric lymphoma10.4
50hepatitis a10.4

Graphical network of the top 20 diseases related to Acute Lymphocytic Leukemia:



Diseases related to acute lymphocytic leukemia

Clinical Features for Acute Lymphocytic Leukemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

613065,613067,247640

Drugs & Therapeutics for Acute Lymphocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Lymphocytic Leukemia

Search NIH Clinical Center for Acute Lymphocytic Leukemia

Search CenterWatch for Acute Lymphocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Lymphocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Lymphocytic Leukemia:
NiCord
Umbilical cord-derived hematopoietic stem cells for treatment of acute lymphoblastic leukemia
Embryonic/Adult Cultured Cells Related to Acute Lymphocytic Leukemia:
Umbilical cord blood-derived stem cells (NiCord), PMID: 22198152
Umbilical cord blood-derived hematopoietic stem cells (family), PMID: 17968329

Genetic Tests for Acute Lymphocytic Leukemia

Anatomical Context for Acute Lymphocytic Leukemia

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Acute Lymphocytic Leukemia:

33
Skin, Liver, Spinal cord, Brain, Kidney, Spleen, Bone marrow, Thyroid, Breast, Prostate, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Pineal

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Lymphocytic Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease
3 BloodHematopoietic Bone MarrowSmall Pre B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Acute Lymphocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Lymphocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.7TAL1, IKZF1, HOXD4, CDKN1C, CDX2, CDKN2B
2MP:000537610.6TCF3, MTHFR, BCR, MTR, SHMT1, CDKN2B
3MP:000538710.6BCR, TCF3, MME, IKZF1, CDKN1C, CDKN2B
4MP:000539710.5TAL1, TAL2, IKZF1, CDKN1C, CDX1, NUP98
5MP:000537810.3TCF3, NUP98, CDKN1C, CDX2, HOXD4, IKZF1

Publications for Acute Lymphocytic Leukemia

Sources:
51PubMed
See all sources

Articles related to Acute Lymphocytic Leukemia:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Results of inotuzumab ozogamicin, a CD22 monoclonal antibody, in refractory and relapsed acute lymphocytic leukemia. (23633004)
2013
2
Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice. (23301070)
2013
3
Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737. (23723123)
2013
4
Diagnosis of large granular lymphocytic leukemia in a patient previously treated for acute myeloblastic leukemia. (24416499)
2013
5
Human leukocyte antigen (HLA)-DRB1*14 is associated with a high incidence of acute lymphocytic leukemia. (22868506)
2012
6
Ovarian reserve in women treated for acute lymphocytic leukemia or acute myeloid leukemia with chemotherapy, but not stem cell transplantation. (23050166)
2012
7
Case of the disappearing subdural hygromas in a pediatric patient with acute lymphocytic leukemia. (22957755)
2012
8
Leser-TrAclat sign presenting in a patient with recurrent pre-B-cell acute lymphocytic leukemia. (22439308)
2012
9
Acute myeloid leukemia presenting with cutaneous infiltrates in a patient receiving etanercept for chronic lymphocytic vasculitis. (23158628)
2012
10
Exposure to magnetic fields and childhood acute lymphocytic leukemia in SALo Paulo, Brazil. (21840286)
2011
11
Radiation-induced glioblastoma multiforme in a remitted acute lymphocytic leukemia patient. (22102955)
2011
12
Development of Bullous Acrodermatitis Enteropathica during the Course of Chemotherapy for Acute Lymphocytic Leukemia. (22346269)
2011
13
FLT3 mutations in canine acute lymphocytic leukemia. (21272320)
2011
14
Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatment. (21536647)
2011
15
Peripheral ulcerative keratitis with bilateral optic nerve involvement as an initial presentation of acute lymphocytic leukemia in an adult. (18008055)
2009
16
A case of optic neuropathy after short-term linezolid use in a patient with acute lymphocytic leukemia. (19231981)
2009
17
miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. (17934639)
2007
18
Treatment of acute lymphocytic leukemia using zinc adjuvant with chemotherapy and radiation--a case history and hypothesis. (15823699)
2005
19
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. (16081687)
2005
20
Outcomes of unrelated cord blood transplants and allogeneic-related hematopoietic stem cell transplants in children with high-risk acute lymphocytic leukemia. (15361908)
2004
21
Genotoxicity of therapeutic intervention in children with acute lymphocytic leukemia. (15231655)
2004
22
Evaluation of patient age as a risk assigment parameter in high risk acute lymphocytic leukemia. (12898748)
2003
23
Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia. (12651272)
2003
24
Acute lymphocytic leukemia after fulminant varicella associated with severe neutropenia. (12356115)
2002
25
Ventral polyradiculopathy with pediatric acute lymphocytic leukemia. (11754193)
2002
26
Cutaneous lymphocytic vasculitis as the presenting feature of acute lymphoblastic leukemia. (12368694)
2002
27
Autologous stem cell transplantation for acute lymphocytic leukemia in adults. (11253604)
2001
28
Development of systemic lupus erythematosus following autologous bone marrow transplant for acute lymphocytic leukemia. (11409148)
2001
29
Prevalence of myeloperoxidase gene expression in infant acute lymphocytic leukemia. (9802341)
1998
30
Pseudomonas aeruginosa blepharoconjunctivitis during cytoreductive chemotherapy in a woman with acute lymphocytic leukemia. (9368482)
1997
31
Acute lymphocytic leukemia associated with severe myelofibrosis. (9444932)
1997
32
Changes in red blood cell methotrexate pharmacology and their impact on outcome when cytarabine is infused with methotrexate in the treatment of acute lymphocytic leukemia in children: a pediatric oncology group study. (9816176)
1996
33
Two cases of mature B-cell acute lymphocytic leukemia with normal karyotype in adults. (8922497)
1996
34
Time trends in survival of children with acute lymphocytic leukemia in Piedmont, Italy: a report from the Population-Based Cancer Registry. (7571021)
1995
35
Complete remission achieved by low-dose Ara-C, aclarubicin and rhG-CSF (CAG) therapy in acute non-lymphocytic leukemia with monosomy 7 occurring after severe aplastic anemia]. (7536277)
1995
36
Characteristics and outcome of patients with acute lymphocytic leukemia and myeloperoxidase-positive blasts by electron microscopy. (7860434)
1994
37
Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes. (8207989)
1994
38
From the Centers for Disease Control and Prevention. Change in source of information: availability of varicella vaccine for children with acute lymphocytic leukemia. (8315766)
1993
39
Deletions of the short arm of chromosome 9, including the interferon-alpha/-beta genes, in acute lymphocytic leukemia. Studies on loss of heterozygosity, parental origin of deleted genes and prognosis. (8100807)
1993
40
Adult and childhood acute lymphocytic leukemia: are they different diseases? (8416287)
1993
41
Effects of stem cell factor (SCF) on the in vitro growth of leukemic blast progenitors in acute non-lymphocytic leukemia. (7693028)
1993
42
Intensive chemotherapy with mitoxantrone and high-dose cytosine arabinoside followed by granulocyte-macrophage colony-stimulating factor in the treatment of patients with acute lymphocytic leukemia. (1737098)
1992
43
Overexpression of c-fos in a human pre-B cell acute lymphocytic leukemia derived cell line, SMS-SB. (1704120)
1991
44
Improved results of an intensified therapy in adult acute lymphocytic leukemia. (2009234)
1991
45
Deletion of alpha-, beta-, and omega-interferon genes in malignant cells from children with acute lymphocytic leukemia. (1701354)
1990
46
Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children. (2355954)
1990
47
Acute lymphocytic leukemia with Philadelphia chromosome and rearrangements of bcr gene and deletion of 5' side and of TCR-delta gene]. (2145450)
1990
48
Acute lymphocytic leukemia treatment: effects on learning. (2778595)
1989
49
Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study. (2778483)
1989
50
Results of therapy in adult acute lymphocytic leukemia. (1064827)
1975

Genetic Variations for Acute Lymphocytic Leukemia

Expression for genes affiliated with Acute Lymphocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for Acute Lymphocytic Leukemia.

Pathways for genes affiliated with Acute Lymphocytic Leukemia

Sources:
4Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG, 50PharmGKB, 54Reactome
See all sources

Compounds for genes affiliated with Acute Lymphocytic Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1dihydrofolate4510.9MTHFR, MTR, SHMT1, TYMS, CDKN2B
2b vitamins4510.9TYMS, SHMT1, MTR, MTHFR
3folate4510.9MTHFR, MTR, SHMT1, TYMS, IKZF1
4tetrahydrofolate4510.9TYMS, SHMT1, MTR, MTHFR
5vitamin b64510.9MTHFR, MTR, SHMT1, TYMS
6pyridoxal 5-phosphate4510.9TYMS, SHMT1, MTR, MTHFR
7serine4510.9MTHFR, MTR, SHMT1, TYMS, CDKN2B, TAL1
8methotrexate45 50 1112.9MTHFR, MTR, SHMT1, TYMS, CDKN2B
9cytarabine45 50 1112.9TYMS, CDKN2B, MME, BCR
10Tetrahydrofolic acid11 2411.9SHMT1, MTR, MTHFR
11purine45 2411.9TYMS, SHMT1, MTR, MTHFR
12thymidylate4510.9MTHFR, MTR, SHMT1, TYMS
13thymidine45 2411.9MTHFR, TYMS, CDX2, MME, BCR
145-aza-2deoxycytidine4510.8CDKN2B, CDX1, CDX2, CDKN1C
15methyl-group4510.8MTR, MTHFR
16ch2h4folate4510.8TYMS, MTHFR
17adenosylcobalamin45 2411.8MTR, MTHFR
185,10-methenyltetrahydrofolate4510.8MTR, MTHFR
19vitamin b124510.8MTHFR, MTR, TYMS
20methylcobalamin45 2411.8MTR, MTHFR
21pemetrexed50 1111.8TYMS, MTHFR
22retinoic acid45 2411.7MTHFR, CDKN2B, CDX1, HOXD4, TAL1, MME
23cyanocobalamin50 11 2412.7MTHFR, MTR
24hydroxocobalamin45 1111.7MTHFR, MTR
2510-formyltetrahydrofolate4510.7MTHFR, MTR
26methionine4510.7MTHFR, MTR, SHMT1, MME
27cysteine4510.7MTHFR, MTR, TYMS, CDX2, MME, BCR
285-methyltetrahydrofolate45 1111.6MTR, MTHFR
29betaine45 2411.6MTR, MTHFR
30homocysteine45 2411.5MTHFR, MTR, SHMT1
31methylmalonic acid45 2411.5MTR, MTHFR
32capecitabine45 50 1112.4TYMS, MTHFR
33cystathionine4510.2MTR, MTHFR

GO Terms for genes affiliated with Acute Lymphocytic Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tetrahydrofolate interconversionGO:03599910.7MTHFR, SHMT1
2Peyers patch developmentGO:04854110.7TCF3, IKZF1
3megakaryocyte differentiationGO:03021910.7CDKN2B, TAL1
4folic acid metabolic processGO:04665510.6MTHFR, SHMT1
5water-soluble vitamin metabolic processGO:00676710.6MTR, MTHFR, SHMT1
6vitamin metabolic processGO:00676610.5MTHFR, MTR, SHMT1
7negative regulation of phosphorylationGO:04232610.5CDKN2B, CDKN1C
8natural killer cell differentiationGO:00177910.4IKZF1, TCF3
9positive regulation of transcription from RNA polymerase II promoterGO:04594410.2TAL1, IKZF1, CDX1, CDKN2B, TCF3

Molecular functions related to Acute Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00098010.5TAL1, CDX1
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1C, CDKN2B

Products for genes affiliated with Acute Lymphocytic Leukemia

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Sources for Acute Lymphocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet