Acute Megakaryoblastic Leukemia malady

Wikipedia: Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are...⁴⁴ more...

MalaCards: Acute Megakaryoblastic Leukemia, also known as megakaryoblastic leukemia, acute, is related to down syndrome and acute myeloid leukemia. An important gene associated with Acute Megakaryoblastic Leukemia is RBM15B (RNA binding motif protein 15B), and among its related pathways are Imatinib Pathway, Pharmacokinetics/Pharmacodynamics and Pathways in cancer. The compounds carbamazepine and aspartate have been mentioned in the context of this disorder. Affiliated tissues include myeloid, t cells and b cells, and related mouse phenotypes are endocrine/exocrine gland and integument.

acute megakaryoblastic leukemia 30 megakaryoblastic leukemia, acute 33

megakaryoblastic leukemia acute 32 acute megakaryocytic leukemias 43

Diseases related to acute megakaryoblastic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 256)

id	Related Disease	Score	Top Affiliating Genes
1	down syndrome	34.3	JAK2, MNX1, MLL, FLT3, ETV6, RUNX1
2	acute myeloid leukemia	30.2	PICALM, KIT, FLT3, RUNX1
3	megakaryocytic leukemia	30.0	VWF, RBM15, RBM6, MPO, JAK2, CD36
4	myelofibrosis	29.7	KIT, MPL, JAK2, IL3, CSF3
5	myeloproliferative disorder	29.0	KIT, VWF, MPL, MPO, JAK2, MLL
6	twinning	27.8	VWF, MPO, CD36, MNX1, MLL, IL6
7	leukemia	26.6	PICALM, KIT, VWF, RBM15, RBM15B, RBM6
8	megakaryoblastic leukemia	26.6	PICALM, KIT, VWF, RBM15, RBM15B, RBM6
9	myeloid leukemia	21.0	PICALM, KIT, VWF, RBM15, BMP6, MPL
10	papillary epithelial neoplasm	13.7	RBM15, SPEN
11	gray platelet syndrome	13.5	CD36, GP9, GATA1
12	macrothrombocytopenia	13.5	CD36, GP9, GATA1
13	congenital amegakaryocytic thrombocytopenia	13.5	MPL, IL3
14	essential thrombocythemia	13.4	MPL, JAK2
15	chronic neutrophilic leukemia	13.4	MLL, CSF3
16	leukemoid reaction	13.3	IL3, CSF3, GATA1
17	chronic cystitis	13.3	KIT, RBM6
18	virus associated hemophagocytic syndrome	13.3	MLL, CSF3
19	dyserythropoietic anemia with thrombocytopenia	13.3	MPL, IL3, CSF3
20	cyclic hematopoiesis	13.2	IL3, CSF3
21	severe congenital neutropenia	13.2	IL3, CSF3
22	mesoblastic nephroma	13.1	KIT, ETV6
23	bone marrow cancer	13.1	KIT, FLT3, IL3
24	mast cell neoplasm	13.1	KIT, FLT3, IL3
25	blood platelet disease	13.1	VWF, GP9, RUNX1
26	pancytopenia	13.0	MPL, MLL, IL3, CSF3
27	cellulitis	13.0	CD36, IL3, CSF3
28	erythrocytosis	13.0	MPL, JAK2, IL3
29	variegate porphyria	13.0	BMP6, CD36, CSF3, GATA1
30	al amyloidosis	12.9	VWF, IL3, CSF3
31	hemorrhagic disease	12.9	VWF, CD36, RUNX1
32	acute monocytic leukemia	12.9	MPO, MLL, FLT3, NUP98
33	leukemia, acute nonlymphocytic	12.9	MLL, IL3, ABCB1
34	cyclic thrombocytopenia	12.9	IL3, IL6
35	hypereosinophilic syndrome	12.8	KIT, JAK2, IL3
36	cblc	12.8	KIT, MPL, JAK2, CSF1R
37	juvenile myelomonocytic leukemia	12.8	JAK2, FLT3, RUNX1
38	splenomegaly	12.8	MPL, JAK2, CSF3, RUNX1, GATA1
39	uterine sarcoma	12.7	KIT, ABCB1, CSF1R
40	myeloid sarcoma	12.7	KIT, MPO, MLL, FLT3
41	sm-ahnmd	12.6	KIT, MPO, JAK2
42	dna topoisomerase ii	12.6	MLL, ABCB1, NUP98, RUNX1
43	crescentic glomerulonephritis	12.6	KIT, BMP6, MPO, CD36
44	poems syndrome	12.6	CD36, IL6, CSF3
45	boomerang dysplasia	12.6	MLL, FLT3, ABCG2, RUNX1, GATA1
46	breast adenocarcinoma	12.6	BMP6, CD36, ABCB1, ABCG2
47	stem cell leukemia	12.5	KIT, MPO, FLT3, RUNX1, GATA1
48	acute myelomonocytic leukemia	12.5	MPO, MLL, ETV6, CSF1R, RUNX1
49	mastocytosis	12.5	KIT, MPO, JAK2, IL3
50	cadasil	12.5	MPO, IL6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to acute megakaryoblastic leukemia:

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MGI Mouse Phenotypes related to acute megakaryoblastic leukemia:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.2	ETV6, MNX1, MKL1, CSF1R, SPEN
2	integument phenotype	MP:0010771	7.9	GATA1, RUNX1, CSF3, CSF1R, ABCG2, SPEN
3	skeleton phenotype	MP:0005390	7.9	KIT, BMP6, MLL, IL6, CSF1R, RUNX1
4	tumorigenesis	MP:0002006	7.7	MLL, PML, ETV6, IL6, IL3, RUNX1
5	liver/biliary system phenotype	MP:0005370	7.4	PICALM, GATA1, CD36, MLL, IL6, KIT
6	growth/size phenotype	MP:0005378	6.2	FLT3, IL6, MLL, MNX1, CD36, JAK2
7	cardiovascular system phenotype	MP:0005385	6.0	IL6, MKL1, VWF, BACH1, MPO, CD36
8	mortality/aging	MP:0010768	5.4	IL6, FLT3, MKL1, MLL, ETV6, SPEN
9	homeostasis/metabolism phenotype	MP:0005376	4.7	JAK2, MPO, BACH1, KIT, MPL, PICALM
10	cellular phenotype	MP:0005384	4.7	PICALM, VWF, KIT, RBM15, NUP98, ABCB1
11	immune system phenotype	MP:0005387	4.1	CSF1R, RBM15, PML, FLT3, NUP98, ABCB1
12	hematopoietic system phenotype	MP:0005397	4.0	SPEN, MPL, RBM15, VWF, KIT, PICALM

Articles related to acute megakaryoblastic leukemia:

(show all 36)

id	Title	Authors	Year	Affiliating Genes
1	Acute megakaryoblastic leukemia with a four-way varia nt translocation originating the RBM15-MKL1 fusion gene. (21370421)	Torres L.... Teixeira M.R.	2011	RBM15
2	Identification of a novel, tissue-specific ABCG2 prom oter expressed in pediatric acute megakaryoblastic leukemia. (21640380)	Campbell P.K.... Sorrentino B.P.	2011	ABCG2
3	Acute megakaryoblastic leukemia without GATA1 mutatio n after transient myeloproliferative disorder in an infant without Down syndrom e. (21205752)	Inaba H.... Raimondi S.C.	2011	GATA1
4	Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Jan us kinase 3 mutations in normal subjects. (21599579)	Riera L.... Inghirami G.	2011	JAK3
5	The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model. (19287095)	Mercher T.... Gilliland D.G.	2009	MPL
6	Activating mutations in human acute megakaryoblastic leukemia. (18755984)	Malinge S.... Bernard O.A.	2008	KIT, JAK2, JAK3
7	MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia and expression of the MNX1 gene in leukemia and normal B cell lines. (18940475)	Taketani T.... Hayashi Y.	2008	ETV6, MNX1
8	Tetrasomy 21 as a sole acquired abnormality without GATA1 gene mutation in pediatric acute megakaryoblastic leukemia: a case report and review of the literature. (18372039)	Shin M.G.... Ryang D.W.	2008	GATA1
9	A novel mutation in the GATA1 gene associated with acute megakaryoblastic leukemia in a Korean Down syndrome patient. (19119459)	Kim I.S.... Chi H.S.	2008	GATA1
10	High incidence of CALM-AF10 fusion and the identification of a novel fusion transcript in acute megakaryoblastic leukemia in children without Down's syndrome. (17170719)	Abdelhaleem M.... Shago M.	2007	PICALM
11	JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults. (17252020)	Kiyoi H.... Naoe T.	2007	JAK3
12	Acute megakaryoblastic leukemia in Down syndrome. (17943965)	Hitzler J.K.	2007	GATA1
13	A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. (17360941)	Gu T.L.... Polakiewicz R.D.	2007	CSF1R, RBM6
14	Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. (16492768)	Bourquin J.P.... Orkin S.H.	2006	BACH1
15	Acute megakaryoblastic leukemia and loss of the RUNX1 gene. (16364766)	Berger R.... Romana S.P.	2006	RUNX1
16	Activating alleles of JAK3 in acute megakaryoblastic leukemia. (16843266)	Walters D.K.... Druker B.J.	2006	JAK3
17	CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. (17071479)	Savasan S.... Ravindranath Y.	2006	CD36
18	Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome. (16628190)	Xu G.... Ito E.	2006	RUNX1, GATA1
19	Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5. (16778363)	Kanezaki R.... Ito E.	2006	FXR2
20	GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia. (15390312)	Crispino J.D.	2005	GATA1
21	GATA 1 mutations as clonal markers of minimal residual disease in acute megakaryoblastic leukemia of Down syndrome--a new tool with significant potential applications. (15925405)	Hitzler J.... Zipursky A.	2005	GATA1
22	Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia. (16028218)	Tosi S.... Harbott J.	2005	NUP98, CCDC28A
23	MLL-MLLT10 fusion gene in pediatric acute megakaryoblastic leukemia. (16111539)	Morerio C.... Panarello C.	2005	MLL
24	Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome. (14684662)	Shimada A.... Ito E.	2004	GATA1
25	The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome. (15070711)	Harigae H.... Ito E.	2004	GATA1
26	Mutations in GATA1 in both transient myeloproliferative disorder and acute megakaryoblastic leukemia of Down syndrome. (14636651)	Greene M.E.... Crispino J.D.	2003	GATA1
27	The potential effect of short-course high-dose steroid on the maturation and apoptosis of leukemic cells in a child with acute megakaryoblastic leukemia. (12854906)	Hicsonmez G.... Gurgey A.	2003	GP9
28	GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. (12586620)	Hitzler J.K.... Zipursky A.	2003	GATA1
29	Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. (11431691)	Ma Z.... Hitzler J.K.	2001	MKL1, RBM15
30	Characteristics of a cell line established from a cas e of acute megakaryoblastic leukemia. (9210910)	Skinnider L.F.... Zheng C.Y.	1997	IL3
31	Expression of MDR-1/P-glycoprotein in childhood acute megakaryoblastic leukemia cells. (8590843)	Ota S.... Tsuruo T.	1995	ABCB1
32	Immunolocalization of platelet-derived growth factor, transforming growth factor-beta, and fibronectin in acute megakaryoblastic leukemia manifesting tumor formation. (8026832)	Kitagawa M.... Kamiyama R.	1994	CD36
33	Acute megakaryoblastic leukemia in one cat and two dogs. (8470339)	Colbatzky F.... Hermanns W.	1993	VWF, MPO
34	Induction of complete remission in a case of drug-resistant childhood acute megakaryoblastic leukemia by combination of G-CSF and chemotherapy (1374487)	Sugita K.... Miyauchi J.	1992	CSF3
35	Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin-3 and interleukin-6: an ultrastructural cytochemical study. (1655816)	Miyauchi J.... Shimizu K.	1991	IL6, IL3
36	The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis. (2317561)	Terui T.... Saito H.	1990	BMP6

Genes related to acute megakaryoblastic leukemia according to GeneCards:

(show all 32)

id	Symbol	Description	Score	GeneCards Section Context
1	RBM15B	RNA binding motif protein 15B	11.0	Orthologs
2	GATA1	GATA binding protein 1 (globin transcription factor 1)	11.0	Publications
3	CCDC28A	coiled-coil domain containing 28A	11.0	Publications
4	RBM15	RNA binding motif protein 15	11.0	Publications, Orthologs
5	MNX1	motor neuron and pancreas homeobox 1	11.0	Publications
6	GP9	glycoprotein IX (platelet)	11.0	Publications
7	FXR2	fragile X mental retardation, autosomal homolog 2	11.0	Publications
8	BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	11.0	Publications
9	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
10	MKL1	megakaryoblastic leukemia (translocation) 1	11.0	Publications
11	SPEN	spen homolog, transcriptional regulator (Drosophila)	11.0	Orthologs
12	RBM6	RNA binding motif protein 6	11.0	Publications
13	NUP98	nucleoporin 98kDa	11.0	Publications
14	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
15	PML	promyelocytic leukemia	11.0	Publications
16	PICALM	phosphatidylinositol binding clathrin assembly protein	11.0	Publications
17	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
18	FLT3	fms-related tyrosine kinase 3	11.0	Publications
19	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
20	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	11.0	Publications
21	RUNX1	runt-related transcription factor 1	11.0	Publications
22	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
23	BMP6	bone morphogenetic protein 6	11.0	Publications
24	ETV6	ets variant 6	11.0	Publications
25	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
26	VWF	von Willebrand factor	11.0	Publications
27	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
28	JAK2	Janus kinase 2	11.0	Publications
29	MPO	myeloperoxidase	11.0	Publications
30	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
31	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
32	JAK3	Janus kinase 3	10.2	Publications

Pathways related to acute megakaryoblastic leukemia according to GeneDecks:

(show all 40)

id	Pathway	Score	Top Affiliating Genes
1	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics34	10.6	ABCG2
2	Pathways in cancer20	9.9	CSF1R, RUNX1, PML, FLT3
3	Ras Pathway36	9.9	IL3, KIT, FLT3, CSF1R
4	Acute myeloid leukemia20	9.8	KIT, RUNX1, PML, FLT3
5	ILK Signaling36	9.7	CSF1R, KIT, IL3, FLT3
6	Akt Signaling36	9.6	IL6, KIT, FLT3
7	Tyrosine Kinases / Adaptors3	9.5	KIT, FLT3, JAK2, CSF1R
8	Molecular Mechanisms of Cancer36	9.5	BMP6, CSF1R, IL6, IL3
9	Abacavir transport and metabolism38	9.4	ABCB1, ABCG2
10	Lymphocyte Signaling3	9.1	MPO, RUNX1, GATA1, KIT
11	Cellular Apoptosis Pathway36	9.1	BMP6, PML, IL6, KIT, IL3
12	MIF Mediated Glucocorticoid Regulation36	9.1	BMP6, IL6, IL3, CSF3
13	Cytokine production by Th17 cells in CF41	9.1	CSF3, IL6, JAK2
14	MIF Regulation of Innate Immune Cells36	9.0	BMP6, IL3, IL6, CSF3
15	Nanog in Mammalian ESC Pluripotency36	9.0	CSF1R, IL3, BMP6, KIT, FLT3, IL6
16	Jak-STAT signaling pathway20	9.0	MPL, IL3, IL6, JAK2, CSF3
17	Paxillin Interactions36	9.0	FLT3, IL3, KIT, BMP6, IL6, CSF1R
18	14-3-3 Induced Intracellular Signaling36	9.0	BMP6, CSF1R, IL6, FLT3, KIT, IL3
19	eNOS Signaling36	8.9	KIT, BMP6, FLT3, IL3, IL6, CSF1R
20	NFAT in Immune Response36	8.9	IL3, FLT3, KIT, IL6, BMP6, CSF1R
21	Estrogen Pathway36	8.9	FLT3, BMP6, KIT, IL6, CSF1R, IL3
22	GPCR Pathway36	8.9	IL6, CSF1R, FLT3, BMP6, KIT, IL3
23	GSK3 Signaling36	8.9	IL6, IL3, FLT3, BMP6, KIT, CSF1R
24	JNK Pathway36	8.9	CSF1R, KIT, BMP6, FLT3, IL3, IL6
25	Activation of PKA through GPCR36	8.8	CSF1R, IL3, KIT, BMP6, FLT3, IL6
26	Intracellular Calcium Signaling36	8.8	CSF1R, IL3, BMP6, FLT3, KIT, IL6
27	p70S6K Signaling36	8.8	IL6, KIT, IL3, JAK2, BMP6
28	Renin-Angiotensin Pathway36	8.7	BMP6, IL6, IL3, JAK2, KIT
29	Cytokine-cytokine receptor interaction20	8.7	IL6, CSF3, CSF1R, MPL, IL3, FLT3
30	STAT3 Pathway36	8.7	JAK2, BMP6, IL3, CSF3, CSF1R, IL6
31	Endothelin-1 Signaling Pathway36	8.6	CSF1R, BMP6, FLT3, IL3, KIT, IL6
32	MAPK Signaling36	8.6	CSF1R, IL6, FLT3, BMP6, KIT, IL3
33	p38 Signaling36	8.5	IL3, CSF3, CSF1R, IL6, FLT3, BMP6
34	Pancreatic Adenocarcinoma36	8.5	CSF1R, BMP6, KIT, JAK2, FLT3, IL3
35	Hematopoietic cell lineage20	8.5	KIT, IL3, FLT3, CD36, IL6, GP9
36	Rho Family GTPases36	8.5	FLT3, CSF1R, IL6, IL3, KIT, BMP6
37	ERK Signaling36	8.4	CSF3, FLT3, KIT, IL3, IL6, CSF1R
38	JAK-STAT Pathway36	8.4	CSF1R, IL6, FLT3, JAK2, MPL, BMP6
39	Antioxidant Action of Vitamin-C36	8.3	CSF3, BMP6, KIT, CSF1R, IL3, JAK2
40	Activation of cAMP-Dependent PKA36	8.3	IL6, KIT, BMP6, FLT3, IL3, CSF1R

Compounds related to acute megakaryoblastic leukemia according to GeneDecks:

(show top 50)    (show all 130)

id	Compound	Score	Top Affiliating Genes
1	carbamazepine32 34 9 9	13.1	CD36
2	aspartate32	10.0	BMP6, GP9, MLL
3	cysteine32	10.0	BACH1, PML, GP9, MPL
4	vincristine32 34 9 9	13.0	MLL, KIT, ABCG2
5	estrogen32	10.0	VWF, CD36, ABCG2
6	daniplestim32	10.0	CSF3, IL3, FLT3
7	threonine32	9.9	MPL, MLL, CSF1R, GP9, FLT3
8	aclarubicin32	9.8	CSF3, GATA1, IL3
9	dmso32	9.7	CSF1R, GATA1, RUNX1, CD36, BMP6
10	agar32	9.7	ETV6, CSF1R, JAK2
11	il 1132	9.5	IL3, IL6, CSF3
12	pixy32132	9.4	FLT3, CSF3, IL6, IL3
13	nilotinib34 9 9	11.3	ABCG2, KIT, ABCB1
14	homoharringtonine32	9.2	ABCB1, IL3, CSF3
15	gm-csf32	9.2	BMP6, IL6, CSF3, IL3
16	rhodamine 12332 34	10.2	KIT, IL3, ABCB1, ABCG2
17	teniposide32 9 9	11.1	CSF3, ABCG2, ABCB1, MLL
18	hydroxyurea32 9 9	11.1	KIT, JAK2, ABCG2, GATA1, IL3, CSF3
19	sunitinib32 9 9	11.1	CSF1R, ABCG2, FLT3, ABCB1, KIT
20	methylcellulose32	9.0	KIT, FLT3, IL3, CSF3, IL6
21	epinephrine32 9 18 9	12.0	ABCG2, ABCB1, JAK2, BMP6
22	idarubicin32 9 9	11.0	CSF3, FLT3, IL3, ABCB1, ABCG2
23	sorafenib32 9 9	10.8	FLT3, KIT, ABCG2, ABCB1
24	doxorubicin32 34 9 9	11.8	BMP6, GATA1, ABCB1, FLT3, KIT, MLL
25	herbimycin a32 42	9.7	BMP6, JAK2, CD36, FLT3, IL3, IL6
26	docetaxel32 34 9 9	11.7	KIT, IL3, ABCG2, ABCB1, CSF3
27	leucine32	8.7	JAK2, BACH1, PML, PICALM, MLL, KIT
28	butyrate32	8.7	JAK2, GATA1, RUNX1, BMP6, MPO, IL3
29	cyclosporin a32 42	9.7	JAK2, ABCB1, VWF, ABCG2, IL3
30	etoposide32 42 9 9	11.6	FLT3, IL3, MLL, ABCG2, CSF1R, RUNX1
31	adriamycin32	8.5	CSF3, ABCG2, ABCB1, IL3, CD36
32	mitoxantrone32 9 9	10.4	FLT3, MPO, IL3, ABCB1, ABCG2, CSF3
33	hydrocortisone32 9 9	10.4	ABCG2, ABCB1, IL6, IL3, CD36, BMP6
34	glutamine32	8.2	ABCG2, KIT, VWF, BMP6, IL3, CD36
35	daunorubicin32 9 9	10.2	FLT3, IL3, ABCB1, CSF3, ABCG2, MPO
36	gp 13032	8.2	KIT, MPL, IL6, IL3, FLT3, JAK2
37	methotrexate32 34 42 9 9	12.0	IL6, BMP6, CSF3, ABCG2, ABCB1, KIT
38	cycloheximide32	7.9	KIT, GATA1, IL3, CD36, JAK2, BMP6
39	5fluorouracil32	7.9	MPL, ABCB1, IL3, CD36, MPO, ABCG2
40	oligonucleotide32	7.9	FLT3, VWF, MLL, GATA1, RUNX1, JAK2
41	actinomycin d32	7.8	KIT, JAK2, MLL, IL3, IL6, ABCB1
42	genistein32 9 18 9	10.7	ABCG2, IL3, JAK2, ABCB1, IL6, MLL
43	cytarabine32 34 9 9	10.6	CD36, KIT, MPO, FLT3, IL3, ABCB1
44	serine32	7.2	VWF, KIT, BMP6, MPL, MPO, GATA1
45	imatinib32 34 9 9	10.1	ETV6, IL3, ABCB1, ABCG2, RUNX1, CSF3
46	prednisolone32 9 9	9.0	IL6, BMP6, VWF, RUNX1, CSF3, ABCB1
47	dexamethasone32 42 34 9 9	11.0	IL6, ABCB1, ABCG2, CSF1R, CSF3, IL3
48	tyrosine32	6.4	ABCG2, ETV6, IL6, CSF1R, CSF3, IL3
49	vegf32	6.3	CSF3, RUNX1, GATA1, KIT, FLT3, CSF1R
50	retinoic acid32 42 18	7.7	IL6, FLT3, MLL, CD36, ETV6, CSF1R

Biological processes related to acute megakaryoblastic leukemia according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	myeloid progenitor cell differentiation	GO:002318	9.9	KIT, FLT3, RUNX1
2	hemopoiesis	GO:030097	9.6	RUNX1, CSF1R, FLT3, KIT
3	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.5	IL3, JAK2, KIT
4	embryonic hemopoiesis	GO:035162	9.5	IL3, KIT, RUNX1, GATA1, MLL
5	erythrocyte differentiation	GO:030218	9.4	GATA1, JAK2, KIT
6	peptidyl-tyrosine phosphorylation	GO:018108	9.4	CSF1R, FLT3, JAK2, KIT
7	positive regulation of MAPK cascade	GO:043410	9.1	KIT, CD36, FLT3, IL6
8	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.1	JAK2, FLT3, KIT
9	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	9.1	JAK2, KIT, CSF1R, IL6
10	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	IL6, IL3, CD36, JAK2, GATA1
11	blood coagulation	GO:007596	9.0	GATA1, CD36, JAK2, MPL, VWF, GP9
12	platelet activation	GO:030168	8.9	VWF, MPL, GP9, CD36, IL6
13	positive regulation of cell proliferation	GO:008284	8.2	KIT, JAK2, FLT3, IL3, IL6, CSF1R
14	cytokine-mediated signaling pathway	GO:019221	8.1	IL6, FLT3, JAK2, KIT, NUP98, CSF1R

Molecular functions related to acute megakaryoblastic leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	xenobiotic-transporting ATPase activity	GO:008559	9.4	ABCG2, ABCB1
2	protein homodimerization activity	GO:042803	8.2	RUNX1, KIT, VWF, MLL, FLT3, ABCG2
3	protein binding	GO:005515	5.3	GATA1, RUNX1, PML, NUP98, ABCG2, ABCB1