MCID: ACT200
MIFTS: 47

Acute Monoblastic Leukemia

Categories: Rare diseases, Cancer diseases, Blood diseases

Aliases & Classifications for Acute Monoblastic Leukemia

MalaCards integrated aliases for Acute Monoblastic Leukemia:

Name: Acute Monoblastic Leukemia 49 55 69
Acute Monocytic Leukemia 49 55 69
Aml M5 49 55
M5b Acute Differentiated Monocytic Leukemia 69
Acute Monocytic/monoblastic Leukemia 69
Acute Myeloblastic Leukemia Type 5 49
Aml-M5 49

Characteristics:

Orphanet epidemiological data:

55
acute monoblastic leukemia
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Childhood;

Classifications:



External Ids:

Orphanet 55 ORPHA514
MESH via Orphanet 42 D007948
UMLS via Orphanet 70 C0457334 C1318544 C0023465
ICD10 via Orphanet 33 C92.7
ICD10 32 C93.0

Summaries for Acute Monoblastic Leukemia

NIH Rare Diseases : 49 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 514Disease definitionAcute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML; see this term) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).Visit the Orphanet disease page for more resources. Last updated: 11/10/2015

MalaCards based summary : Acute Monoblastic Leukemia, also known as acute monocytic leukemia, is related to monocytic leukemia and myeloma, multiple. An important gene associated with Acute Monoblastic Leukemia is LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma), and among its related pathways/superpathways are Pathways in cancer and Transcriptional misregulation in cancer. The drugs Mitoxantrone and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, monocytes and bone.

Related Diseases for Acute Monoblastic Leukemia

Diseases related to Acute Monoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 monocytic leukemia 32.1 CSF2 CXCL8 IL6 KMT2A
2 myeloma, multiple 29.6 CD44 CSF2 CXCL8 IL6
3 adult acute monocytic leukemia 12.6
4 leukemia, acute monocytic 11.2
5 leukemia 10.7
6 engraftment syndrome 10.4 CSF2 CXCL8
7 giant papillary conjunctivitis 10.4 CXCL8 IL7
8 felty syndrome 10.4 CSF2 CXCL8
9 cyclic neutropenia 10.4 CSF2 CXCL8
10 natural killer cell leukemia 10.3 EPO IL7
11 recurrent corneal erosion 10.3 CXCL8 IL6
12 bagassosis 10.3 CXCL8 IL6
13 acute transverse myelitis 10.3 CXCL8 IL6
14 streptococcal toxic-shock syndrome 10.3 CXCL8 IL6
15 denture stomatitis 10.3 CXCL8 IL6
16 funisitis 10.3 CXCL8 IL6
17 b-cell growth factor 10.3 IL6 IL7
18 neutrophilia, hereditary 10.3 CSF2 IL6
19 vibrio vulnificus infection 10.3 EPO IL6
20 vaginal disease 10.3 CXCL8 IL6
21 ascaris lumbricoides infection 10.2 IL6 IL7
22 louse-borne relapsing fever 10.2 CXCL8 IL6
23 arteriovenous fistula 10.2 EPO IL6
24 vaginitis 10.2 CXCL8 IL6
25 preterm premature rupture of the membranes 10.2 CXCL8 IL6
26 sarcoma 10.2
27 endometrial disease 10.2 CXCL8 IL6
28 transverse myelitis 10.2 CXCL8 IL6
29 poems syndrome 10.2 EPO IL6
30 necrotizing fasciitis 10.2 CXCL8 IL6
31 cowpox 10.2 CXCL8 IL6
32 bacteriuria 10.1 CXCL8 IL6
33 papillary conjunctivitis 10.1 CXCL8 IL6 IL7
34 pulpitis 10.1 CXCL8 IL6
35 anemia of prematurity 10.1 CSF2 EPO
36 capillary leak syndrome 10.1 CSF2 CXCL8 IL6
37 meconium aspiration syndrome 10.1 CSF2 CXCL8 IL6
38 mastitis 10.1 CSF2 CXCL8 IL6
39 respiratory system disease 10.1 CSF2 CXCL8 IL6
40 emanuel syndrome 10.0 LOC108449888 LOC108449897
41 pharyngitis 10.0 CSF2 CXCL8
42 kaposi sarcoma 10.0 CSF2 CXCL8 IL6
43 acute cystitis 10.0 CXCL8 IL6
44 thrombocytosis 10.0 CSF2 EPO IL6
45 myelodysplastic syndrome 10.0
46 disseminated intravascular coagulation 10.0
47 myeloid sarcoma 10.0
48 acquired immunodeficiency syndrome 10.0 CSF2 EPO IL6
49 immune system disease 10.0 CSF2 EPO IL6
50 endosteal hyperostosis, autosomal dominant 9.9

Graphical network of the top 20 diseases related to Acute Monoblastic Leukemia:



Diseases related to Acute Monoblastic Leukemia

Symptoms & Phenotypes for Acute Monoblastic Leukemia

Drugs & Therapeutics for Acute Monoblastic Leukemia

Drugs for Acute Monoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 216)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 3,Phase 2,Phase 1 65271-80-9 4212
2
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323
3
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
4
Idarubicin Approved Phase 3,Phase 2,Phase 1,Early Phase 1 58957-92-9 42890
5
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
6
Amsacrine Approved, Investigational Phase 3 51264-14-3 2179
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
8
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1 55-98-1 2478
9
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
10
Mesna Approved, Investigational Phase 3 3375-50-6 598
11
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
12
Clofarabine Approved, Investigational Phase 2, Phase 3, Phase 1 123318-82-1 119182
13
Thioguanine Approved Phase 3,Phase 1 154-42-7 2723601
14
Aldesleukin Approved Phase 3,Phase 1,Phase 2 110942-02-4, 85898-30-2
15
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
16
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
17
Melphalan Approved Phase 2, Phase 3, Phase 1 148-82-3 460612 4053
18
Hydroxyurea Approved Phase 3 127-07-1 3657
19
Fludarabine Approved Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
20
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 657311 5754
21
alemtuzumab Approved, Investigational Phase 2, Phase 3,Phase 1 216503-57-0
22
Asparaginase Approved, Investigational Phase 3,Phase 2,Phase 1 9015-68-3
23
Carmustine Approved, Investigational Phase 3 154-93-8 2578
24
Azacitidine Approved, Investigational Phase 2, Phase 3, Phase 1 320-67-2 9444
25
Arsenic trioxide Approved, Investigational Phase 2, Phase 3,Phase 1 1327-53-3 518740
26
Decitabine Approved, Investigational Phase 3,Phase 2,Phase 1 2353-33-5 451668
27
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
28
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
29
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
30
Cyproheptadine Approved Phase 3 129-03-3 2913
31
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2,Phase 1 302-79-4 5538
32
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
33
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
34
tipifarnib Investigational Phase 2, Phase 3,Phase 1 192185-72-1 159324
35 Staurosporine Experimental Phase 3,Phase 1 62996-74-1
36
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
37 Analgesics Phase 3,Phase 2,Phase 1
38 Alkylating Agents Phase 3,Phase 2,Phase 1
39 Gemtuzumab Phase 2, Phase 3, Phase 1
40 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
41 Vaccines Phase 3,Phase 1
42 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1
43 Dermatologic Agents Phase 3,Phase 2,Phase 1
44 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
45 Antibodies, Monoclonal Phase 3,Phase 2
46 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Early Phase 1
47 Anti-HIV Agents Phase 3,Phase 1,Phase 2
48 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
49 Antifungal Agents Phase 3,Phase 2,Phase 1,Early Phase 1
50 Immunoglobulins Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 182)

# Name Status NCT ID Phase Drugs
1 Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia in Remission Unknown status NCT00454168 Phase 3
2 Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00002549 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mesna;mitoxantrone hydrochloride
3 Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia Unknown status NCT00006045 Phase 3 cytarabine;etoposide;mitoxantrone hydrochloride
4 Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Unknown status NCT00091234 Phase 2, Phase 3 gemtuzumab ozogamicin
5 Combination Chemotherapy, Interleukin-2, and Peripheral Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00004128 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide
6 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
7 Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
8 Combination Chemotherapy With or Without Valspodar in Treating Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00003190 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar
9 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Completed NCT00002798 Phase 3 asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
10 Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
11 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
12 Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia Completed NCT00005863 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;tretinoin
13 Cytarabine and Daunorubicin With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00121303 Phase 3 cytarabine;daunorubicin hydrochloride;gemtuzumab ozogamicin
14 Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Completed NCT00454480 Phase 2, Phase 3 arsenic trioxide;azacitidine;busulfan;clofarabine;cytarabine;daunorubicin hydrochloride;fludarabine phosphate;gemtuzumab ozogamicin;melphalan;tipifarnib
15 Chemotherapy With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00052299 Phase 3 cytarabine;etoposide;gemtuzumab ozogamicin;idarubicin;mitoxantrone hydrochloride
16 Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia Completed NCT00046930 Phase 3 cytarabine;daunorubicin hydrochloride;zosuquidar trihydrochloride;Placebo
17 S0106 Cytarabine and Daunorubicin w/ or w/o Gemtuzumab Followed By HD Cytarabine and Either Gemtuzumab or Nothing in de Novo AML Completed NCT00085709 Phase 3 gemtuzumab ozogamicin;Cytosine arabinoside;Daunomycin
18 Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia Completed NCT00112554 Phase 3 cytarabine;laromustine
19 Combination Chemotherapy With or Without G-CSF in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00002719 Phase 3 amsacrine;carmustine;cytarabine;etoposide;idarubicin;mitoxantrone hydrochloride
20 Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00005823 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;hydroxyurea;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin;valspodar
21 flt3L in Treating Patients With Acute Myeloid Leukemia Completed NCT00006223 Phase 3
22 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00002517 Phase 3 cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine
23 Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome Completed NCT00003593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;methotrexate;therapeutic hydrocortisone;thioguanine
24 High Dose Chemotherapy, Peripheral Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00002945 Phase 3 cyclophosphamide;cytarabine;etoposide;idarubicin;melphalan
25 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3 caspofungin acetate;fluconazole
26 Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
27 Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT00651261 Phase 3 cytarabine;daunorubicin;midostaurin;dexamethasone acetate
28 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
29 Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant Unknown status NCT02038153 Phase 1, Phase 2 Lenalidomide
30 Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00003405 Phase 2 amifostine trihydrate;bromodeoxyuridine;cytarabine;idarubicin;idoxuridine;isotretinoin;mitoxantrone hydrochloride
31 Combination Chemotherapy in Treating Patients With Relapsed Acute Myelogenous Leukemia Unknown status NCT00003758 Phase 2 cytarabine;idarubicin
32 Clofarabine, Cytarabine, and Idarubicin in Treating Patients With Intermediate-Risk or High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplasia Unknown status NCT00838240 Phase 1, Phase 2 clofarabine;cytarabine;idarubicin
33 VNP40101M Followed by Cytarabine in Treating Older Patients With Acute Myeloid Leukemia Unknown status NCT00354276 Phase 2 cytarabine;laromustine
34 Bexarotene and GM-CSF in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Unknown status NCT00425477 Phase 2 bexarotene
35 Monoclonal Antibody in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00006084 Phase 2
36 Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia Completed NCT00666588 Phase 2 idarubicin;cytarabine;bortezomib;etoposide
37 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma Completed NCT01177371 Phase 2 busulfan;cyclophosphamide;methylprednisolone;methotrexate;cyclosporine
38 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
39 Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00027872 Phase 2 tipifarnib
40 Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia Completed NCT01870596 Phase 2 Cytarabine;CHK1 Inhibitor SCH 900776
41 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia Completed NCT01361464 Phase 2 Tipifarnib
42 Busulfan, Fludarabine Phosphate, and Anti-Thymocyte Globulin Followed By Donor Stem Cell Transplant and Azacitidine in Treating Patients With High-Risk Myelodysplastic Syndrome and Older Patients With Acute Myeloid Leukemia Completed NCT01168219 Phase 2 Azacitidine;Busulfan;Fludarabine Phosphate;Methotrexate;Tacrolimus
43 Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia Completed NCT02144675 Phase 2 choline magnesium trisalicylate;idarubicin;cytarabine
44 Alvocidib, Cytarabine, and Mitoxantrone Hydrochloride or Cytarabine and Daunorubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT01349972 Phase 2 alvocidib;daunorubicin hydrochloride;mitoxantrone hydrochloride;cytarabine
45 AKT Inhibitor MK-2206 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT01253447 Phase 2 Akt inhibitor MK2206
46 Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy Completed NCT01235572 Phase 2
47 Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML Completed NCT00895934 Phase 1, Phase 2 vorinostat;gemtuzumab ozogamicin;azacitidine
48 Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT00634244 Phase 2 alvocidib;mitoxantrone hydrochloride;carboplatin;cytarabine;sirolimus;etoposide;topotecan hydrochloride
49 Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00795002 Phase 2 alvocidib;mitoxantrone hydrochloride;cytarabine
50 Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00742625 Phase 1, Phase 2 daunorubicin hydrochloride;cytarabine;bortezomib

Search NIH Clinical Center for Acute Monoblastic Leukemia

Genetic Tests for Acute Monoblastic Leukemia

Anatomical Context for Acute Monoblastic Leukemia

MalaCards organs/tissues related to Acute Monoblastic Leukemia:

38
Myeloid, Monocytes, Bone, Bone Marrow, Prostate, Lung, B Cells

Publications for Acute Monoblastic Leukemia

Articles related to Acute Monoblastic Leukemia:

(show all 49)
# Title Authors Year
1
Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm. ( 29417354 )
2018
2
Central hypothyroidism in a pediatric case of primary acute monoblastic leukemia with central nervous system infiltration: A case report. ( 28658145 )
2017
3
Acute monoblastic leukemia presenting with striking periorbital and periauricular infiltration. ( 28642361 )
2017
4
Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16). ( 28272065 )
2017
5
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia. ( 29442054 )
2017
6
Pseudo Chediak-Higashi anomaly in acute monoblastic leukemia. ( 27884836 )
2016
7
Spontaneous remission of aleukemic cutaneous myeloid sarcoma followed by crisis of acute monoblastic leukemia. ( 26661142 )
2016
8
Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity. ( 26960652 )
2016
9
Isolated central nervous system primary acute monoblastic leukemia presenting as papilledema. ( 27569601 )
2016
10
Acute monoblastic leukemia presented with multiple granulocytic sarcoma nodules. ( 27094724 )
2016
11
Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse. ( 27268298 )
2016
12
Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements. ( 25548462 )
2015
13
Transfusion medicine illustrated. Blast cell fragments mimic platelets in acute monoblastic leukemia. ( 26074175 )
2015
14
Concurrent Acute Monoblastic Leukemia and Multiple Myeloma in a 66-Year-Old Chemotherapy-Naive Woman. ( 29147380 )
2014
15
Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin. ( 23975227 )
2013
16
A rare cryptic and complex rearrangement leading to MLL-MLLT10 gene fusion masked by del(10)(p12) in a child with acute monoblastic leukemia (AML-M5). ( 22261229 )
2012
17
MLL-ELL fusion gene in two infants with acute monoblastic leukemia and myeloid sarcoma. ( 22149207 )
2012
18
CD44 activation enhances acute monoblastic leukemia cell survival via Mcl-1 upregulation. ( 21993315 )
2012
19
Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia: a case report. ( 22217491 )
2012
20
Successful Administration of Recombinant Human Soluble Thrombomodulin I+ (Recomodulin) for Disseminated Intravascular Coagulation during Induction Chemotherapy in an Elderly Patient with Acute Monoblastic Leukemia Involving the t(9;11)(p22;q23) MLL/AF9 Translocation. ( 22937304 )
2011
21
Polyradiculoneuritis revealing an acute monoblastic leukemia 5. ( 21293744 )
2010
22
Successful treatment of Aspergillus liver abscesses in a patient with acute monoblastic leukemia using combination antifungal therapy including micafungin as a key drug. ( 20352380 )
2010
23
Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype. ( 20303016 )
2010
24
Acute monoblastic leukemia with abnormal granules and disseminated intravascular coagulation: diagnostic pitfalls. ( 19806662 )
2009
25
Monoblastic sarcoma cutis preceding acute monoblastic leukemia. ( 19051330 )
2009
26
A complex 1;19;11 translocation involving the MLL gene in a patient with congenital acute monoblastic leukemia identified by molecular and cytogenetic techniques. ( 19107484 )
2009
27
A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia. ( 18000862 )
2008
28
Chemotherapy-induced acral erythema in a pediatric patient with acute monoblastic leukemia. ( 18432504 )
2008
29
Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: a case report and literature review. ( 18556867 )
2008
30
Donor cell-derived acute monoblastic leukemia involving MLL gene translocation in an adult patient who received umbilical cord blood transplantation. ( 17982506 )
2008
31
Acute monoblastic leukemia in a FeLV-positive cat. ( 18296895 )
2008
32
Tetrasomy 8 in a patient with acute monoblastic leukemia. ( 18728374 )
2008
33
Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of acute monoblastic leukemia. ( 17914409 )
2008
34
Dramatic response of acute monoblastic leukemia to a single dose of docetaxel. ( 18297537 )
2008
35
Trisomy 22 as sole cytogenetic abnormality in acute monoblastic leukemia (M5b). ( 16875946 )
2006
36
Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation. ( 15621793 )
2005
37
Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute monoblastic leukemia: association of rare genetic disorders and childhood malignant diseases. ( 12116087 )
2002
38
Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia. ( 11719396 )
2001
39
p230 does not always predict a mild clinical course in myeloid malignancies: e19a2 bcr/abl fusion transcript with additional chromosome abnormalities in a patient with acute monoblastic leukemia (M5a). ( 11255282 )
2001
40
t(11;14)(q23;q24) generates an MLL-human gephyrin fusion gene along with a de facto truncated MLL in acute monoblastic leukemia. ( 11289145 )
2001
41
Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement. ( 9594441 )
1998
42
Characterization of a novel malignant B cell line with t(14;18) and t(4;11) established from a patient with acute monoblastic leukemia. ( 9293903 )
1997
43
Ultrastructural localization of myeloperoxidase activity in acute monoblastic leukemia. ( 8161732 )
1993
44
Cutis verticis gyrata secondary to acute monoblastic leukemia. ( 8103266 )
1993
45
Acute monoblastic leukemia of infancy in Klinefelter's syndrome. ( 1638488 )
1992
46
Translocation t(11;22)(q23;q11) in an adult with acute monoblastic leukemia. ( 2089178 )
1990
47
Acute monoblastic leukemia with osteosclerosis and extensive myelofibrosis. ( 3239709 )
1988
48
Brachial plexus neuropathy following high-dose cytarabine in acute monoblastic leukemia. ( 2992782 )
1985
49
A possible specific chromosome marker for monocytic leukemia: three more patients with t(9;11)(p22;q24) and another with t(11;17)(q24;q21), each with acute monoblastic leukemia. ( 6572092 )
1983

Variations for Acute Monoblastic Leukemia

Expression for Acute Monoblastic Leukemia

Search GEO for disease gene expression data for Acute Monoblastic Leukemia.

Pathways for Acute Monoblastic Leukemia

Pathways related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 12.62 CXCL8 EPO IL6 IL7
2 12 CSF2 CXCL8 IL6 KMT2A
3
Show member pathways
12 CSF2 EPO IL6 IL7
4 11.73 CSF2 CXCL8 IL6
5
Show member pathways
11.7 CSF2 CXCL8 IL6
6 11.68 CSF2 CXCL8 IL6
7 11.65 CSF2 CXCL8 IL6
8 11.61 CSF2 CXCL8 IL6
9 11.49 CSF2 CXCL8 IL6
10 11.48 CD44 CXCL8 IL6 KMT2A
11
Show member pathways
11.47 CSF2 CXCL8 IL6
12 11.42 CD44 CSF2 EPO IL6 IL7
13 11.36 CD44 CXCL8 IL6
14 11.27 CSF2 CXCL8 IL6
15 11.23 CSF2 EPO IL6
16 11.12 CSF2 CXCL8
17 11.09 IL6 IL7
18 11.01 CD44 CSF2 EPO IL6 IL7
19 10.99 CSF2 CXCL8 IL6 IL7
20 10.91 CSF2 IL6 IL7
21 10.85 CXCL8 IL6

GO Terms for Acute Monoblastic Leukemia

Biological processes related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.76 CD44 EPO IL6 IL7
2 positive regulation of cell proliferation GO:0008284 9.73 CSF2 EPO IL6 IL7
3 immune response GO:0006955 9.62 CSF2 CXCL8 IL6 IL7
4 cellular response to fibroblast growth factor stimulus GO:0044344 9.4 CD44 CXCL8
5 homeostasis of number of cells within a tissue GO:0048873 9.37 IL7 KMT2A
6 cellular response to lipopolysaccharide GO:0071222 9.33 CSF2 CXCL8 IL6
7 positive regulation of chemokine production GO:0032722 9.26 IL6 IL7
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 CSF2 EPO IL6
9 regulation of receptor activity GO:0010469 9.02 CSF2 CXCL8 EPO IL6 IL7

Molecular functions related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 CSF2 IL6 IL7
2 cytokine activity GO:0005125 9.02 CSF2 CXCL8 EPO IL6 IL7

Sources for Acute Monoblastic Leukemia

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
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58 PubMed
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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