MCID: ACT200
MIFTS: 42

Acute Monoblastic Leukemia

Categories: Rare diseases, Blood diseases, Cancer diseases

Aliases & Classifications for Acute Monoblastic Leukemia

MalaCards integrated aliases for Acute Monoblastic Leukemia:

Name: Acute Monoblastic Leukemia 50 56 69
Acute Monocytic Leukemia 50 56 69
Aml M5 50 56
M5b Acute Differentiated Monocytic Leukemia 69
Acute Monocytic/monoblastic Leukemia 69
Acute Myeloblastic Leukemia Type 5 50
Aml-M5 50

Characteristics:

Orphanet epidemiological data:

56
acute monoblastic leukemia
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Childhood;

Classifications:



External Ids:

Orphanet 56 ORPHA514
MESH via Orphanet 43 D007948
UMLS via Orphanet 70 C0457334 C1318544 C0023465
ICD10 via Orphanet 34 C92.7

Summaries for Acute Monoblastic Leukemia

NIH Rare Diseases : 50 the following summary is from orphanet, a european reference portal for information on rare diseases and orphan drugs.orpha number: 514disease definitionacute monoblastic leukemia (aml-m5), is one of the most common subtypes of acute myeloid leukemia (aml; see this term) that is either comprised of more than 80% of monoblasts (aml-m5a) or 30-80% monoblasts with (pro)monocytic differentiation (aml-m5b). aml-m5 presents with asthenia, pallor, fever, and dizziness. specific features of aml-m5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. leukemia cutis and gingival infiltration can also be seen. a characteristic translocation observed in aml-m5 is t(9;11).visit the orphanet disease page for more resources. last updated: 11/10/2015

MalaCards based summary : Acute Monoblastic Leukemia, also known as acute monocytic leukemia, is related to monocytic leukemia and acute monocytic leukemia. An important gene associated with Acute Monoblastic Leukemia is LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Jak-STAT signaling pathway (KEGG). The drugs Cytarabine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow.

Related Diseases for Acute Monoblastic Leukemia

Diseases related to Acute Monoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Related Disease Score Top Affiliating Genes
1 monocytic leukemia 11.4
2 acute monocytic leukemia 11.1
3 leukemia 10.6
4 enterovesical fistula 10.6 CSF2 CXCL8
5 cystic adventitial disease 10.6 CSF2 IL7
6 retinal vascular disease 10.6 CXCL8 IL7
7 lymphangiectasia, intestinal 10.6 CSF2 CXCL8
8 breast fibroadenosis 10.5 EPO IL7
9 oculomotor nerve paralysis 10.5 CXCL8 IL6
10 common peroneal nerve lesion 10.5 CXCL8 IL6
11 drug rash with eosinophilia and systemic symptoms 10.5 CXCL8 IL6
12 spirillary rat-bite fever 10.5 CXCL8 IL6
13 schwannoma of ureter 10.5 CXCL8 IL6
14 infancy electroclinical syndrome 10.4 CXCL8 IL6
15 brachydactyly-distal symphalangism syndrome 10.4 CSF2 IL6
16 virilizing ovarian tumor 10.4 EPO IL6
17 osteogenesis imperfecta, type x 10.4 CXCL8 IL6
18 subglottis neoplasm 10.4 CXCL8 IL6
19 bullous retinoschisis 10.4 CXCL8 IL6
20 asphyxia neonatorum 10.4 EPO IL6
21 cicatricial lagophthalmos 10.4 CXCL8 IL6
22 carbuncle 10.4 CXCL8 IL6
23 autosomal dominant polycystic kidney disease 10.3 CXCL8 IL6
24 bipolar i disorder 10.3 EPO IL6
25 orthostatic proteinuria 10.3 CXCL8 IL6
26 tricho onychic dysplasia 10.3 CXCL8 IL6
27 lateral cystocele 10.3 CXCL8 IL6
28 psychotic disorder 10.2 CXCL8 IL6 IL7
29 hidradenitis 10.2 CSF2 CXCL8
30 myofascial pain syndrome 10.2 CXCL8 IL6 IL7
31 labyrinthine bilateral reactive loss 10.2 CSF2 CXCL8 IL6
32 pasteurellosis 10.2 CSF2 CXCL8 IL6
33 chronic endophthalmitis 10.2 CSF2 CXCL8 IL6
34 acquired thrombocytopenia 10.2 CXCL8 IL6
35 acute chest syndrome 10.2 CSF2 CXCL8 IL6
36 sarcoma 10.1
37 polyarteritis nodosa, childhood-onset 10.1 LOC108449888 LOC108449897
38 dysphagia 10.1 CXCL8 IL6
39 intracranial hemorrhage in brain cerebrovascular malformations 10.1 CSF2 CXCL8 IL6
40 granulomatous hepatitis 10.1 CSF2 EPO IL6
41 acral lentiginous melanoma 10.1 CSF2 EPO IL6
42 lacrimal system cancer 10.1 CSF2 EPO IL6
43 dic in newborn 10.0 CSF2 EPO
44 myelodysplastic syndrome 9.9
45 disseminated intravascular coagulation 9.9
46 myeloid sarcoma 9.9
47 histiocytic and dendritic cell cancer 9.9 CD44 CSF2 CXCL8 IL6
48 reticulosarcoma 9.9 CSF2 CXCL8 IL6 KMT2A
49 cpt deficiency, hepatic, type ia 9.9 CD44 CSF2 IL6
50 cranioectodermal dysplasia 1 9.9 CSF2 IL6 KMT2A LPP

Graphical network of the top 20 diseases related to Acute Monoblastic Leukemia:



Diseases related to Acute Monoblastic Leukemia

Symptoms & Phenotypes for Acute Monoblastic Leukemia

Drugs & Therapeutics for Acute Monoblastic Leukemia

Drugs for Acute Monoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 215)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
2
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
3
Mitoxantrone Approved, Investigational Phase 3,Phase 2,Phase 1 65271-80-9 4212
4
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1 55-98-1 2478
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
6
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323
7
Idarubicin Approved Phase 3,Phase 2,Phase 1,Early Phase 1 58957-92-9 42890
8
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
9
Mesna Approved Phase 3 3375-50-6 598
10
Aldesleukin Approved Phase 3,Phase 1,Phase 2 85898-30-2, 110942-02-4
11
Amsacrine Approved Phase 3 51264-14-3 2179
12
Thioguanine Approved Phase 3,Phase 1 154-42-7 2723601
13
Clofarabine Approved, Investigational Phase 2, Phase 3, Phase 1 123318-82-1 119182
14
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
15
Asparaginase Approved Phase 3,Phase 2,Phase 1 9015-68-3
16
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
17
Fludarabine Approved Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
18
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754 657311
19
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
20
Hydroxyurea Approved Phase 3 127-07-1 3657
21
alemtuzumab Approved, Investigational Phase 2, Phase 3,Phase 1 216503-57-0
22
Arsenic trioxide Approved, Investigational Phase 2, Phase 3,Phase 1 1327-53-3 518740
23
Azacitidine Approved, Investigational Phase 2, Phase 3, Phase 1 320-67-2 9444
24
Melphalan Approved Phase 2, Phase 3, Phase 1 148-82-3 4053 460612
25
Carmustine Approved Phase 3 154-93-8 2578
26
Decitabine Approved, Investigational Phase 3,Phase 2,Phase 1 2353-33-5 451668
27
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
28
Fluconazole Approved Phase 3 86386-73-4 3365
29
Cyproheptadine Approved Phase 3 129-03-3 2913
30
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
31
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2,Phase 1 302-79-4 5538
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
33
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
34
Butyric Acid Experimental Phase 3 107-92-6 264
35
tipifarnib Investigational Phase 2, Phase 3,Phase 1 192185-72-1 159324
36 Staurosporine Experimental Phase 3,Phase 1 62996-74-1
37 Analgesics Phase 3,Phase 2,Phase 1
38 Antibodies Phase 3,Phase 2
39 Antibodies, Monoclonal Phase 3,Phase 2
40 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
41 Antimetabolites Phase 3,Phase 2,Phase 1,Early Phase 1
42 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Early Phase 1
43 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
44 Antiviral Agents Phase 3,Phase 2,Phase 1,Early Phase 1
45 Etoposide phosphate Phase 3,Phase 2,Phase 1
46 Immunoglobulins Phase 3,Phase 2
47 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
48 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
49 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
50 Alkylating Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 182)

id Name Status NCT ID Phase Drugs
1 Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia Unknown status NCT00006045 Phase 3 cytarabine;etoposide;mitoxantrone hydrochloride
2 Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00002549 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mesna;mitoxantrone hydrochloride
3 Combination Chemotherapy, Interleukin-2, and Peripheral Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00004128 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide
4 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
5 Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia in Remission Unknown status NCT00454168 Phase 3
6 Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Unknown status NCT00091234 Phase 2, Phase 3 gemtuzumab ozogamicin
7 Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
8 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Completed NCT00002798 Phase 3 asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
9 Combination Chemotherapy With or Without Valspodar in Treating Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00003190 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar
10 Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
11 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
12 Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia Completed NCT00005863 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;tretinoin
13 flt3L in Treating Patients With Acute Myeloid Leukemia Completed NCT00006223 Phase 3
14 Cytarabine and Daunorubicin With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00121303 Phase 3 cytarabine;daunorubicin hydrochloride;gemtuzumab ozogamicin
15 Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia Completed NCT00046930 Phase 3 cytarabine;daunorubicin hydrochloride;zosuquidar trihydrochloride;Placebo
16 Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia Completed NCT00112554 Phase 3 cytarabine;laromustine
17 Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00005823 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;hydroxyurea;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin;valspodar
18 Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Completed NCT00454480 Phase 2, Phase 3 arsenic trioxide;azacitidine;busulfan;clofarabine;cytarabine;daunorubicin hydrochloride;fludarabine phosphate;gemtuzumab ozogamicin;melphalan;tipifarnib
19 Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome Completed NCT00003593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;methotrexate;therapeutic hydrocortisone;thioguanine
20 Combination Chemotherapy With or Without G-CSF in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00002719 Phase 3 amsacrine;carmustine;cytarabine;etoposide;idarubicin;mitoxantrone hydrochloride
21 Chemotherapy With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00052299 Phase 3 cytarabine;etoposide;gemtuzumab ozogamicin;idarubicin;mitoxantrone hydrochloride
22 S0106 Cytarabine and Daunorubicin w/ or w/o Gemtuzumab Followed By HD Cytarabine and Either Gemtuzumab or Nothing in de Novo AML Completed NCT00085709 Phase 3 gemtuzumab ozogamicin;Cytosine arabinoside;Daunomycin
23 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00002517 Phase 3 cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine
24 High Dose Chemotherapy, Peripheral Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00002945 Phase 3 cyclophosphamide;cytarabine;etoposide;idarubicin;melphalan
25 Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
26 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3 caspofungin acetate;fluconazole
27 Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT00651261 Phase 3 cytarabine;daunorubicin;midostaurin;dexamethasone acetate
28 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
29 Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant Unknown status NCT02038153 Phase 1, Phase 2 Lenalidomide
30 Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00003405 Phase 2 amifostine trihydrate;bromodeoxyuridine;cytarabine;idarubicin;idoxuridine;isotretinoin;mitoxantrone hydrochloride
31 Combination Chemotherapy in Treating Patients With Relapsed Acute Myelogenous Leukemia Unknown status NCT00003758 Phase 2 cytarabine;idarubicin
32 VNP40101M Followed by Cytarabine in Treating Older Patients With Acute Myeloid Leukemia Unknown status NCT00354276 Phase 2 cytarabine;laromustine
33 Monoclonal Antibody in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00006084 Phase 2
34 Clofarabine, Cytarabine, and Idarubicin in Treating Patients With Intermediate-Risk or High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplasia Unknown status NCT00838240 Phase 1, Phase 2 clofarabine;cytarabine;idarubicin
35 Bexarotene and GM-CSF in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Unknown status NCT00425477 Phase 2 bexarotene
36 Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia Completed NCT00666588 Phase 2 idarubicin;cytarabine;bortezomib;etoposide
37 Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00027872 Phase 2 tipifarnib
38 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma Completed NCT01177371 Phase 2 busulfan;cyclophosphamide;methylprednisolone;methotrexate;cyclosporine
39 Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia Completed NCT01870596 Phase 2 Cytarabine;CHK1 Inhibitor SCH 900776
40 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia Completed NCT01361464 Phase 2 Tipifarnib
41 Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT00634244 Phase 2 alvocidib;mitoxantrone hydrochloride;carboplatin;cytarabine;sirolimus;etoposide;topotecan hydrochloride
42 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
43 Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia Completed NCT02144675 Phase 2 choline magnesium trisalicylate;idarubicin;cytarabine
44 AKT Inhibitor MK-2206 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT01253447 Phase 2 Akt inhibitor MK2206
45 Alvocidib, Cytarabine, and Mitoxantrone Hydrochloride or Cytarabine and Daunorubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT01349972 Phase 2 alvocidib;daunorubicin hydrochloride;mitoxantrone hydrochloride;cytarabine
46 S0432 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00093418 Phase 2 tipifarnib
47 Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00407966 Phase 2 alvocidib;cytarabine;mitoxantrone hydrochloride
48 Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00742625 Phase 1, Phase 2 daunorubicin hydrochloride;cytarabine;bortezomib
49 Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00795002 Phase 2 alvocidib;mitoxantrone hydrochloride;cytarabine
50 Vorinostat in Treating Patients With Acute Myeloid Leukemia Completed NCT00305773 Phase 2 vorinostat;vorinostat

Search NIH Clinical Center for Acute Monoblastic Leukemia

Genetic Tests for Acute Monoblastic Leukemia

Anatomical Context for Acute Monoblastic Leukemia

MalaCards organs/tissues related to Acute Monoblastic Leukemia:

39
Myeloid, Bone, Bone Marrow, Monocytes, Prostate, Lung, B Cells

Publications for Acute Monoblastic Leukemia

Articles related to Acute Monoblastic Leukemia:

(show all 46)
id Title Authors Year
1
Acute monoblastic leukemia presenting with striking periorbital and periauricular infiltration. ( 28642361 )
2017
2
Central hypothyroidism in a pediatric case of primary acute monoblastic leukemia with central nervous system infiltration: A case report. ( 28658145 )
2017
3
Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16). ( 28272065 )
2017
4
Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity. ( 26960652 )
2016
5
Spontaneous remission of aleukemic cutaneous myeloid sarcoma followed by crisis of acute monoblastic leukemia. ( 26661142 )
2016
6
Acute monoblastic leukemia presented with multiple granulocytic sarcoma nodules. ( 27094724 )
2016
7
Pseudo Chediak-Higashi anomaly in acute monoblastic leukemia. ( 27884836 )
2016
8
Isolated central nervous system primary acute monoblastic leukemia presenting as papilledema. ( 27569601 )
2016
9
Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse. ( 27268298 )
2016
10
Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements. ( 25548462 )
2015
11
Transfusion medicine illustrated. Blast cell fragments mimic platelets in acute monoblastic leukemia. ( 26074175 )
2015
12
Hemophagocytic syndrome in children with acute monoblastic leukemia-another cause of fever of unknown origin. ( 23975227 )
2013
13
A rare cryptic and complex rearrangement leading to MLL-MLLT10 gene fusion masked by del(10)(p12) in a child with acute monoblastic leukemia (AML-M5). ( 22261229 )
2012
14
MLL-ELL fusion gene in two infants with acute monoblastic leukemia and myeloid sarcoma. ( 22149207 )
2012
15
CD44 activation enhances acute monoblastic leukemia cell survival via Mcl-1 upregulation. ( 21993315 )
2012
16
Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia: a case report. ( 22217491 )
2012
17
Successful Administration of Recombinant Human Soluble Thrombomodulin I+ (Recomodulin) for Disseminated Intravascular Coagulation during Induction Chemotherapy in an Elderly Patient with Acute Monoblastic Leukemia Involving the t(9;11)(p22;q23) MLL/AF9 Translocation. ( 22937304 )
2011
18
Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype. ( 20303016 )
2010
19
Polyradiculoneuritis revealing an acute monoblastic leukemia 5. ( 21293744 )
2010
20
Successful treatment of Aspergillus liver abscesses in a patient with acute monoblastic leukemia using combination antifungal therapy including micafungin as a key drug. ( 20352380 )
2010
21
Monoblastic sarcoma cutis preceding acute monoblastic leukemia. ( 19051330 )
2009
22
Acute monoblastic leukemia with abnormal granules and disseminated intravascular coagulation: diagnostic pitfalls. ( 19806662 )
2009
23
A complex 1;19;11 translocation involving the MLL gene in a patient with congenital acute monoblastic leukemia identified by molecular and cytogenetic techniques. ( 19107484 )
2009
24
Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: a case report and literature review. ( 18556867 )
2008
25
Chemotherapy-induced acral erythema in a pediatric patient with acute monoblastic leukemia. ( 18432504 )
2008
26
Tetrasomy 8 in a patient with acute monoblastic leukemia. ( 18728374 )
2008
27
Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of acute monoblastic leukemia. ( 17914409 )
2008
28
Dramatic response of acute monoblastic leukemia to a single dose of docetaxel. ( 18297537 )
2008
29
Donor cell-derived acute monoblastic leukemia involving MLL gene translocation in an adult patient who received umbilical cord blood transplantation. ( 17982506 )
2008
30
A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia. ( 18000862 )
2008
31
Acute monoblastic leukemia in a FeLV-positive cat. ( 18296895 )
2008
32
Trisomy 22 as sole cytogenetic abnormality in acute monoblastic leukemia (M5b). ( 16875946 )
2006
33
Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation. ( 15621793 )
2005
34
Duchenne muscular dystrophy-rhabdomyosarcoma, ichthyosis vulgaris/acute monoblastic leukemia: association of rare genetic disorders and childhood malignant diseases. ( 12116087 )
2002
35
p230 does not always predict a mild clinical course in myeloid malignancies: e19a2 bcr/abl fusion transcript with additional chromosome abnormalities in a patient with acute monoblastic leukemia (M5a). ( 11255282 )
2001
36
Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia. ( 11719396 )
2001
37
t(11;14)(q23;q24) generates an MLL-human gephyrin fusion gene along with a de facto truncated MLL in acute monoblastic leukemia. ( 11289145 )
2001
38
Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement. ( 9594441 )
1998
39
Characterization of a novel malignant B cell line with t(14;18) and t(4;11) established from a patient with acute monoblastic leukemia. ( 9293903 )
1997
40
Ultrastructural localization of myeloperoxidase activity in acute monoblastic leukemia. ( 8161732 )
1993
41
Cutis verticis gyrata secondary to acute monoblastic leukemia. ( 8103266 )
1993
42
Acute monoblastic leukemia of infancy in Klinefelter's syndrome. ( 1638488 )
1992
43
Translocation t(11;22)(q23;q11) in an adult with acute monoblastic leukemia. ( 2089178 )
1990
44
Acute monoblastic leukemia with osteosclerosis and extensive myelofibrosis. ( 3239709 )
1988
45
Brachial plexus neuropathy following high-dose cytarabine in acute monoblastic leukemia. ( 2992782 )
1985
46
A possible specific chromosome marker for monocytic leukemia: three more patients with t(9;11)(p22;q24) and another with t(11;17)(q24;q21), each with acute monoblastic leukemia. ( 6572092 )
1983

Variations for Acute Monoblastic Leukemia

Expression for Acute Monoblastic Leukemia

Search GEO for disease gene expression data for Acute Monoblastic Leukemia.

Pathways for Acute Monoblastic Leukemia

Pathways related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 20)
id Super pathways Score Top Affiliating Genes
1 11.99 CSF2 CXCL8 IL6 KMT2A
2
Show member pathways
11.86 CSF2 EPO IL6 IL7
3 11.73 CSF2 CXCL8 IL6
4
Show member pathways
11.7 CSF2 CXCL8 IL6
5 11.68 CSF2 CXCL8 IL6
6 11.65 CSF2 CXCL8 IL6
7 11.61 CSF2 CXCL8 IL6
8 11.49 CSF2 CXCL8 IL6
9 11.48 CD44 CXCL8 IL6 KMT2A
10
Show member pathways
11.47 CSF2 CXCL8 IL6
11 11.42 CD44 CSF2 EPO IL6 IL7
12 11.36 CD44 CXCL8 IL6
13 11.27 CSF2 CXCL8 IL6
14 11.23 CSF2 EPO IL6
15 11.11 CSF2 CXCL8
16 11.09 IL6 IL7
17 11.01 CD44 CSF2 EPO IL6 IL7
18 10.99 CSF2 CXCL8 IL6 IL7
19 10.91 CSF2 IL6 IL7
20 10.85 CXCL8 IL6

GO Terms for Acute Monoblastic Leukemia

Biological processes related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.76 CSF2 EPO IL6 IL7
2 negative regulation of apoptotic process GO:0043066 9.73 CD44 EPO IL6 IL7
3 immune response GO:0006955 9.56 CSF2 CXCL8 IL6 IL7
4 cellular response to fibroblast growth factor stimulus GO:0044344 9.4 CD44 CXCL8
5 homeostasis of number of cells within a tissue GO:0048873 9.37 IL7 KMT2A
6 cellular response to lipopolysaccharide GO:0071222 9.33 CSF2 CXCL8 IL6
7 response to electrical stimulus GO:0051602 9.32 EPO IL6
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 CSF2 EPO IL6
9 positive regulation of DNA replication GO:0045740 8.8 CSF2 EPO IL6

Molecular functions related to Acute Monoblastic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 CSF2 IL6 IL7
2 cytokine activity GO:0005125 8.92 CSF2 CXCL8 IL6 IL7

Sources for Acute Monoblastic Leukemia

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