MCID: ACT009
MIFTS: 59

Acute Monocytic Leukemia malady

Blood, Cancer categories

Summaries for Acute Monocytic Leukemia

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia. more...

MalaCards: Acute Monocytic Leukemia, also known as acute monoblastic leukemia, is related to acute leukemia and t-cell leukemia. An important gene associated with Acute Monocytic Leukemia is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are LDL Oxidation in Atherogenesis and LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and spinal cord, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Description from OMIM:47 151380

Aliases & Classifications for Acute Monocytic Leukemia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 43NIH Rare Diseases, 47OMIM, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
acute monocytic leukemia:
Prevalence: 1-9/1000000; Age of onset: Childhood


Aliases & Descriptions:

acute monocytic leukemia 8 10 45 49 31 61
acute monoblastic leukemia 8 43 49 47 61
acute monoblastic leukemia and acute monocytic leukemia 8
acute monocytic leukemia without mention of remission 8
acute monocytic leukemia, morphology 8
acute myeloblastic leukemia type 5 49
acute monocytic leukemia, fab m5 8
acute monocytic leukaemia 8
aml-m5 49


External Ids:

Disease Ontology8 DOID:8864
ICD9CM27 206.0
NCIt40 C7318
OMIM47 151380
MeSH35 D007948
MESH via Orphanet36 D007948
ICD10 via Orphanet26 C92.7
SNOMED-CT via Orphanet58 277601005, 278170009, 413441006
UMLS via Orphanet62 C0457334, C1318544

Related Diseases for Acute Monocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acute Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.9MPO, NUP98, CSF1, CREBBP, MLLT10, CD14
2t-cell leukemia31.0EP300, CD40, CRAT, CREBBP
3myeloid sarcoma30.3KMT2A, MPO
4acute myelomonocytic leukemia30.1KMT2A, MPO, CREBBP, CSF1
5acute lymphocytic leukemia30.1EP300, CD40, KMT2A, MLLT10, CREBBP, HOXA9
6acute t cell leukemia10.7
7acute myeloblastic leukemia type 510.5
8acute myeloid leukemia10.4
9plasma cell leukemia10.4
10testicular leukemia10.3
11central nervous system leukemia10.3
12infectious mononucleosis10.3
13chronic monocytic leukemia10.3
14aleukemic monocytic leukemia cutis10.3
15aleukemic leukemia cutis10.3
16cytomegalovirus infection10.3
17ichthyosis vulgaris10.2
18klinefelter's syndrome10.2
19adult t-cell leukemia10.2
20duchenne muscular dystrophy10.2
21brachial plexus neuropathy10.2
22cutis verticis gyrata10.2
23gingival hypertrophy10.2
24neurofibromatosis10.1
25macroglobulinemia10.1
26severe congenital neutropenia10.1
27diabetes insipidus10.1
28hemoglobinuria10.1
29natural killer cell leukemia10.1
30leukostasis10.1
31malignant histiocytosis10.1
32aplastic anemia10.1
33thymic carcinoma10.1
34turner syndrome10.1
35blastic plasmacytoid dendritic cell10.1
36chronic myelomonocytic leukemia10.1
37clostridium septicum infection10.1
38paroxysmal nocturnal hemoglobinuria10.1
39polymyositis10.1
40leukemia/lymphoma, t-cell10.1
41leukemia, acute myeloid, therapy-related10.1
42testicular germ cell tumor10.1
43generalized eruptive histiocytosis10.1
44pancytopenia10.0
45influenza10.0CRAT
46pancreatitis10.0MPO
47sarcoma10.0EP300, CSF1
48glomerulonephritis10.0MPO
49nephritis10.0RARA, MPO
50peritonitis10.0MPO, CD14

Graphical network of the top 20 diseases related to Acute Monocytic Leukemia:



Diseases related to acute monocytic leukemia

Clinical Features for Acute Monocytic Leukemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

151380

Clinical synopsis from OMIM:

151380

Drugs & Therapeutics for Acute Monocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Monocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Monocytic Leukemia

Search NIH Clinical Center for Acute Monocytic Leukemia

Search CenterWatch for Acute Monocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Monocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Monocytic Leukemia:
NiCord
Embryonic/Adult Cultured Cells Related to Acute Monocytic Leukemia:
Umbilical cord blood-derived stem cells (NiCord), PMID: 22198152

Genetic Tests for Acute Monocytic Leukemia

Anatomical Context for Acute Monocytic Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acute Monocytic Leukemia:

33
Bone marrow, Spleen, Spinal cord, Liver, Skin, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Acute Monocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acute Monocytic Leukemia

Sources:
51PubMed
See all sources

Articles related to Acute Monocytic Leukemia:

(show top 50)    (show all 283)
idTitleAuthorsYear
1
Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report. (24396488)
2014
2
Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells. (24263100)
2013
3
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. (22187541)
2011
4
Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. (21745629)
2011
5
Efficiency of GHA priming therapy on patients with acute monocytic leukemia and its mechanism]. (20137150)
2010
6
Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (18592235)
2009
7
A novel translocation, t(3;20)(q13;p13), in acute monocytic leukemia. (19061781)
2009
8
Expression of genes psma6 and slc25a4 in patients with acute monocytic leukemia]. (19840444)
2009
9
Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells. (19117987)
2009
10
A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25). (18642054)
2008
11
Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes. (18790773)
2008
12
Impairment of granulo-monocytic development of human common myeloid progenitors but not of granulo-monocytic progenitors by decreasing stem cell leukemia/T-cell acute leukemia 1 expression. (18436863)
2008
13
Severe acute graft-vs-host disease in a patient with acute monocytic leukemia having a recombination event between HLA-A/B loci from a multiple recombinant family. (17990988)
2007
14
Comparison of cytogenetics and clinical manifestations between M5a and M5b of acute monocytic leukemia. (16928293)
2006
15
A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice. (15951289)
2005
16
Impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia. (15972121)
2005
17
Hypoxemic respiratory failure in a 57-year-old woman with acute monocytic leukemia. (16304323)
2005
18
Remission of acute monocytic leukemia, secondary to treatment with epipodophyllotoxins, in a patient with t(8;16)(p11;p13) and MYST3-CREBBP fusion. (15262444)
2004
19
Acute monocytic leukemia (French-American-British classification M5) does not have a worse prognosis than other subtypes of acute myeloid leukemia: a report from the Eastern Cooperative Oncology Group. (14970186)
2004
20
A phylogenetic comparison between acute monocytic leukemia cells and monocytes-macrophages in lower vertebrates. (12675202)
2003
21
Light chain proteinuria and lysozymuria in a patient with acute monocytic leukemia. (12089194)
2002
22
Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia. (11604555)
2001
23
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (10824998)
2000
24
Tetrasomy 8 evolving into a segmental triplication 8q in a case of acute monocytic leukemia. (10616537)
2000
25
Molecular analysis of the rearranged genome and chimeric mRNAs caused by the t(6;11)(q27;q23) chromosome translocation involving MLL in an infant acute monocytic leukemia. (10719372)
2000
26
Hepatosplenic abscess caused by Curvularia boedijn in a patient with acute monocytic leukemia. (8970227)
1996
27
Double isochromosome 8q as single cytogenetic aberration in acute myelo-monocytic leukemia. (8535230)
1995
28
Unusual pattern of gastric and hepatic infiltration in an infant with acute monocytic leukemia. (7761154)
1995
29
Third case of acute monocytic leukemia (M5) occurring in an HIV-seropositive man: a case report. (7639286)
1995
30
Synthesis and regulation of complement components by human monocytes/macrophages and by acute monocytic leukemia. (8517928)
1993
31
Acute monocytic leukemia with chloroacetate esterase positivity: FAB M4 or M5? (8240517)
1993
32
Acute monocytic leukemia with (8;22)(p11;q13) translocation. Involvement of 8p11 as in classical t(8;16)(p11;p13). (1606561)
1992
33
Orbital tumor in an infant with acute monocytic leukemia associated with chromosome 5q-,t(9p-11q+),11p+. (1762721)
1991
34
"Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia. (1993304)
1991
35
Evidence for the neoplastic involvement of monocytic, eosinophilic and basophilic lineages in acute myelomonocytic leukemia with eosinophilia. (2109454)
1990
36
Tumor necrosis factor alpha down-regulates c-myc mRNA expression and induces in vitro monocytic differentiation in fresh blast cells from patients with acute myeloblastic leukemia. (2359342)
1990
37
A case of acute monocytic leukemia with lysozyme-positive leukemic monocytes and normal serum lysozyme levels. (2469276)
1989
38
A lineage switch in acute monocytic leukemia. A case report. (2751072)
1989
39
An unusual presentation of acute monocytic leukemia: a case report. (3253268)
1988
40
Monocytoid reaction due to cytomegalovirus infection in acute monocytic leukemia. (2856361)
1987
41
t(9;11)(p22;q24) in a patient with acute monocytic leukemia. (3463406)
1986
42
Thymidine kinase isoenzymes in human acute monocytic leukemia. (3856734)
1985
43
Defective mechanisms of immunophagocytosis by leukemic monocytes in childhood acute monocytic leukemia demonstrated by electron microscopy. (6594894)
1984
44
Alkaline phosphatase-positive leukemic monocytes in a child with acute monocytic leukemia. (6419530)
1984
45
Acute myelofibrosis developing into acute monocytic leukemia. A case report. (6580606)
1983
46
Giant granules and rod-shaped inclusions arising de novo in monocytes and macrophages cultured from a patient with acute monocytic leukemia. (6293332)
1982
47
Acute monocytic leukemia complicating combined-modality therapy for localized childhood Ewing's sarcoma. (6949907)
1981
48
Isolation of novel glycoprotein HNC1beta from the urine of a patient with acute monocytic leukemia. (272227)
1978
49
Monocytic leukemia as a cause of acute respiratory obstruction. (4521037)
1974
50
TOTAL body radiation in acute monocytic leukemia. (13571257)
1958

Genetic Variations for Acute Monocytic Leukemia

Expression for genes affiliated with Acute Monocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Monocytic Leukemia

Search GEO for disease gene expression data for Acute Monocytic Leukemia.

Pathways for genes affiliated with Acute Monocytic Leukemia

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MPO, CSF1
210.4EP300, CREBBP
310.4EP300, CREBBP
410.3CREBBP, EP300, NME1
510.3EP300, MPO, CREBBP
610.3CREBBP, CD40, EP300
7
Hide members
10.3RARA, EP300, CREBBP
8
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
10.3CREBBP, EP300, RARA
9
Hide members
10.2CREBBP, CD40, CD14, EP300
1010.2CREBBP, EP300, NME1, RARA
11
Hide members
10.1CSF1, CREBBP, CD40, CD14, EP300, RARA
1210.1RARA, KMT2A, HOXA9, CD14, CD40, MPO

Compounds for genes affiliated with Acute Monocytic Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1pge24510.8CRAT
2estrogen4510.8KMT2A
3butyrate4510.7CSF1, CRAT, CD40
4cyclophosphamide45 50 1112.7CREBBP, CD40, THBD
5aspartate4510.6CRAT, CD14, NME1, KMT2A
6p0034510.6CSF1, CREBBP
7pentoxifylline45 1111.6CRAT, MPO, CD14, THBD
8neopterin4510.6CSF1, CD40, CD14, THBD
9dbc-amp4510.6CREBBP, CRAT, CD14, THBD
10prednisolone45 29 1112.5CSF1, MPO, CD40, CD14, KMT2A, THBD
11dexamethasone45 50 29 1113.5CRAT, LTB4R, CD14, NME1, RARA
12paclitaxel45 50 1112.5CSF1, CRAT, RARA
13creatinine4510.5CSF1, CREBBP, CRAT, CD14, EP300, NME1
14chloramphenicol45 2 1112.5CSF1, CRAT, MPO, CD40, RARA, THBD
151,25 dihydroxy vitamin d34510.5RARA, CD14, CRAT, CSF1
16calcitriol45 60 11 2413.5CSF1, CD14, EP300, NME1, KMT2A, RARA
17pd 98,0594510.5CSF1, CREBBP, CD40, CD14, EP300, RARA
18polyinosinic-polycytidylic acid4510.5CD40, CRAT, CSF1
19vitamin d4510.5CREBBP, CRAT, CD14, EP300, RARA, THBD
20paraffin4510.5CSF1, MPO, CD40, CD14, NME1, RARA
21retinoid4510.5CSF1, CREBBP, CRAT, CD14, EP300, RARA
22serine4510.5CSF1, CREBBP, MPO, EP300, NME1, KMT2A
23etoposide45 50 60 1113.5CSF1, CREBBP, CRAT, EP300, NME1, KMT2A
24doxorubicin45 50 1112.5CSF1, CREBBP, CRAT, CD40, EP300, KMT2A
25lactate4510.4CSF1, CRAT, MPO, CD14, NME1, THBD
26actinomycin d4510.4CSF1, CRAT, CD40, EP300, KMT2A, RARA
27histamine45 29 2412.4THBD, CD14, CD40, MPO, CSF1
28mannose4510.4CSF1, CREBBP, CD40, CD14
29cisplatin45 50 60 1113.4CSF1, CREBBP, CRAT, MPO, EP300, NME1
30superoxide45 2411.4CSF1, CREBBP, MPO, LTB4R, CD40, CD14
31ly2940024510.4CSF1, CD40, CD14, EP300, RARA
32progesterone45 60 29 11 2414.4CSF1, CREBBP, CRAT, CD40, EP300, NME1
33steroid4510.4CREBBP, CRAT, CD40, CD14, EP300, NME1
34alanine4510.4CSF1, CREBBP, LTB4R, CD14, EP300, NME1
35arginine4510.4CSF1, CREBBP, CRAT, CD14, EP300, KMT2A
36oligonucleotide4510.4CRAT, NUP98, CD40, CD14, NME1, KMT2A
37cysteine4510.3CSF1, CREBBP, CD40, CD14, EP300, NME1
38fmlp4510.3CSF1, MPO, LTB4R, CD14
39nitric oxide45 11 2412.3CREBBP, CRAT, MPO, LTB4R, CD40, EP300
40vegf4510.3CSF1, CREBBP, CRAT, MPO, CD40, CD14
41zinc45 2411.3KAT6A, CREBBP, CRAT, MLLT10, CD40, EP300
42forskolin45 50 1112.3THBD, CD14, CD40, CRAT, CREBBP
43mitoxantrone45 50 1112.3CSF1, CREBBP, MPO
44atp45 2911.3CREBBP, CRAT, LTB4R, CD14, EP300, NME1
45ch 554510.2THBD, RARA
46gtp45 2911.2KMT2A, NME1, CD14, NUP98, CRAT
47prostaglandin4510.2CD40, LTB4R, CRAT, CSF1
48tyrosine4510.2CSF1, CREBBP, CD40, EP300, HOXA9, NME1
49retinoic acid45 2411.2THBD, CSF1, CREBBP, CRAT, MPO, LTB4R
50alpha-naphthyl butyrate4510.1CD14, MPO

GO Terms for genes affiliated with Acute Monocytic Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.2CD14, CD40, LTB4R, CSF1
2N-terminal peptidyl-lysine acetylationGO:01807610.1EP300, CREBBP

Molecular functions related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:01640710.4EP300, CREBBP, KAT6A
2histone acetyltransferase activityGO:00440210.3EP300, CREBBP, KAT6A
3transcription factor bindingGO:00813410.2RARA, EP300, CREBBP, KAT6A
4chromatin bindingGO:00368210.2KAT6A, CREBBP, MPO, EP300, KMT2A
5transcription coactivator activityGO:0037139.9KAT6A, CREBBP, EP300, RARA
6zinc ion bindingGO:0082709.9KAT6A, CREBBP, MLLT6, MLLT10, EP300, KMT2A
7protein bindingGO:0055159.6NUP98, MYH7B, MLLT10, MLLT6, CREBBP, KAT6A

Products for genes affiliated with Acute Monocytic Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Monocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet