MCID: ACT009
MIFTS: 50

Acute Monocytic Leukemia malady

Cancer diseases category

Summaries for Acute Monocytic Leukemia

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Wikipedia:63 Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia. more...

MalaCards based summary: Acute Monocytic Leukemia, also known as acute monocytic leukemia without mention of remission, is related to monocytic leukemia and leukemia, and has symptoms including autosomal dominant somatic cell mutationand acute monocytic leukemia. An important gene associated with Acute Monocytic Leukemia is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are Activation of DNA fragmentation factor and LDL Oxidation in Atherogenesis. The compounds alpha-naphthyl butyrate and mitoxantrone have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Acute Monocytic Leukemia

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Acute Monocytic Leukemia, Aliases & Descriptions:

Name: Acute Monocytic Leukemia 30 9 11 43 60
Acute Monocytic Leukemia Without Mention of Remission 9 60
Acute Monoblastic Leukemia and Acute Monocytic Leukemia 9
 
M5b Acute Differentiated Monocytic Leukemia 60
Acute Monocytic Leukemia, Morphology 9
Acute Monocytic Leukemia, Fab M5 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:8864
ICD9CM27 206.0
MeSH33 D007948
NCIt38 C7318

Related Diseases for Acute Monocytic Leukemia

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Diseases in the Monocytic Leukemia family:

acute monocytic leukemia Chronic Monocytic Leukemia
Subacute Monocytic Leukemia

Diseases related to Acute Monocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1monocytic leukemia31.2CD40, THBD, EP300, CSF1, CD14
2leukemia30.9MPO, EP300, CSF1, CREBBP, NME1, CD14
3chronic myelomonocytic leukemia30.5CSF1, MPO
4langerhans-cell histiocytosis30.5CD40, CSF1
5acute pancreatitis30.3CD14, MPO
6acute myelomonocytic leukemia30.3MPO, CSF1, CREBBP
7severe combined immunodeficiency30.2CD40, CSF1
8myeloma30.2CD40, CD14, CSF1
9myelodysplastic syndrome30.2MPO, EP300, CSF1, CREBBP
10neutropenia30.2CD40, CSF1, MPO
11leukemia, acute lymphoblastic30.2CD40, CREBBP, EP300, MPO
12myeloid leukemia30.0MPO, CSF1, CREBBP, NME1, CD14
13histiocytosis10.5
14peripheral vascular disease10.4MPO
15sarcoma10.4
16aleukemic leukemia cutis10.3
17gingivitis10.3
18lymphoblastic leukemia10.3
19respiratory failure10.3
20blastic plasmacytoid dendritic cell10.3
21cytomegalovirus infection10.3
22rubinstein-taybi syndrome10.2CREBBP, EP300
23wegener granulomatosis10.2CD14, MPO
24hepatocellular carcinoma10.2
25nijmegen breakage syndrome10.2
26platelet disorder, familial, with associated myeloid malignancy10.2
27testicular germ cell tumor10.2
28aplastic anemia10.2
29neuroblastoma10.2
30hodgkin lymphoma10.2
31multiple myeloma10.2
32neutropenia, severe congenital 1, autosomal dominant10.2
33chronic lymphocytic leukemia10.2
34hepatitis10.2
35myelofibrosis10.2
36paroxysmal nocturnal hemoglobinuria10.2
37severe congenital neutropenia10.2
38diabetes insipidus10.2
39neurofibromatosis10.2
40leukostasis10.2
41malignant histiocytosis10.2
42testicular leukemia10.2
43macroglobulinemia10.2
44protein c deficiency10.2
45down syndrome10.2
46hemoglobinuria10.2
47lactic acidosis10.2
48pancreatitis10.2
49thymic carcinoma10.2
50turner syndrome10.2

Graphical network of the top 20 diseases related to Acute Monocytic Leukemia:



Diseases related to acute monocytic leukemia

Symptoms for Acute Monocytic Leukemia

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HPO human phenotypes related to Acute Monocytic Leukemia:

id Description Frequency HPO Source Accession
1 autosomal dominant somatic cell mutation HP:0001444
2 acute monocytic leukemia HP:0004845

Drugs & Therapeutics for Acute Monocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Monocytic Leukemia

Search NIH Clinical Center for Acute Monocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Acute Monocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Monocytic Leukemia:
NiCord
Embryonic/Adult Cultured Cells Related to Acute Monocytic Leukemia:
Umbilical cord blood-derived stem cells (NiCord), PMID: 22198152

Genetic Tests for Acute Monocytic Leukemia

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Anatomical Context for Acute Monocytic Leukemia

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MalaCards organs/tissues related to Acute Monocytic Leukemia:

31
Monocytes, Myeloid, Bone, Bone marrow, Skin, Spinal cord, Liver, B cells, Spleen, Testes, T cells

Animal Models for Acute Monocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute Monocytic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6CREBBP, CSF1, EP300, MPO
2MP:00053888.0THBD, EP300, CSF1, CREBBP, CD14
3MP:00053787.4THBD, EP300, CSF1, CREBBP, NME1, CD14
4MP:00053857.4THBD, MPO, EP300, CSF1, CREBBP
5MP:00036317.3THBD, EP300, CSF1, CREBBP, NME1, CD40
6MP:00107687.1THBD, MPO, EP300, CSF1, CREBBP, NME1
7MP:00053876.9THBD, MPO, EP300, CSF1, CREBBP, CD14
8MP:00053976.6CD40, THBD, MPO, EP300, CSF1, CREBBP
9MP:00053766.6THBD, MPO, EP300, CSF1, CREBBP, NME1

Publications for Acute Monocytic Leukemia

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Articles related to Acute Monocytic Leukemia:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Leukemia cutis in a patient with acute monocytic leukemia diagnosed simultaneously with hepatocellular carcinoma: A case study. (24179516)
2013
2
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
3
Role of misfolded N-CoR mediated transcriptional deregulation of Flt3 in acute monocytic leukemia (AML)-M5 subtype. (22514634)
2012
4
Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. (21605636)
2011
5
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. (22187541)
2011
6
Successful treatment of acute monocytic leukemia with intracranial hemorrhage as the first manifestation. (20958870)
2010
7
A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia. (20471517)
2010
8
Effect of epigallocatechin-3-galate on human acute monocytic leukemia cell line U937 and its relevant mechanism]. (20416153)
2010
9
A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25). (18642054)
2008
10
Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. (18928586)
2008
11
Bioinformatic analysis and identification for a novel antigen MLAA-22 in acute monocytic leukemia]. (18549609)
2008
12
Acute monocytic leukemia and multiple abnormalities in a child with duplication of 1q detected by GTG-banding and SKY. (15964069)
2005
13
Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo. (16880981)
2005
14
Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21). (16105757)
2005
15
Prognosis of acute monocytic leukemia (French-American-British classification M5). (15718341)
2005
16
Remission of acute monocytic leukemia, secondary to treatment with epipodophyllotoxins, in a patient with t(8;16)(p11;p13) and MYST3-CREBBP fusion. (15262444)
2004
17
Acute monocytic leukemia (French-American-British classification M5) does not have a worse prognosis than other subtypes of acute myeloid leukemia: a report from the Eastern Cooperative Oncology Group. (14970186)
2004
18
Simultaneous presentation of multiple myeloma and acute monocytic leukemia. (14567751)
2003
19
Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia. (12645654)
2003
20
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
21
Light chain proteinuria and lysozymuria in a patient with acute monocytic leukemia. (12089194)
2002
22
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. (11243405)
2001
23
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (10824998)
2000
24
Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia. (10905060)
2000
25
Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22. (11150605)
2000
26
Involvement of the MLL and RARalpha genes in a patient with acute monocytic leukemia with t(11;17)(q23;q12) (10720155)
2000
27
Spurious elevation of automated platelet counts in secondary acute monocytic leukemia associated with tumor lysis syndrome. (10539919)
1999
28
Effective treatment of thymic carcinoma with operation and combination chemotherapy against acute monocyte leukemia: case report and review of the literature. (9793029)
1998
29
Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia. (8721686)
1996
30
Infantile acute monocytic leukemia with tumor formation in the skin expressing adhesion molecules as seen by electronmicroscopy. (9021702)
1996
31
Unusual pattern of gastric and hepatic infiltration in an infant with acute monocytic leukemia. (7761154)
1995
32
Acute monocytic leukemia: a single institution experience. (8535217)
1995
33
Heavy-chain immunoglobulin gene rearrangement and cytoplasmic immunoglobulin expression in acute monocytic leukemia following primary germ cell tumor. (7533544)
1995
34
Establishment of a monocytoid cell line (DOP-M1) from an infant with acute monocytic leukemia. (1581583)
1992
35
Intracerebral chloroma complicating acute monocytic leukemia. (1603221)
1992
36
Severe lactic acidosis due to thiamine deficiency after bone marrow transplantation in a child with acute monocytic leukemia. (2129119)
1990
37
Acute monocytic leukemia with B cell markers expression following B chronic lymphocytic leukemia. (2587203)
1989
38
Neurofibromatosis and acute monocytic leukemia in adults. (2507124)
1989
39
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
40
Acute monocytic leukemia in children. Response to VP-16-213 as a single agent. (3326651)
1987
41
Acute monocytic leukemia presenting in the eyelid. An immunohistochemical and electron microscopic study. (3468454)
1986
42
Defective mechanisms of immunophagocytosis by leukemic monocytes in childhood acute monocytic leukemia demonstrated by electron microscopy. (6594894)
1984
43
Acute monocytic leukemia: a surface marker study. (6951407)
1982
44
Acute monocytic leukemia complicating combined-modality therapy for localized childhood Ewing's sarcoma. (6949907)
1981
45
Electron microscopic studies on leukemic cells in suspension culture in childhood acute monocytic leukemia. (284701)
1979
46
Positive monospot tests preceding the diagnosis of acute monocytic leukemia in two adolescents. (275531)
1978
47
Pure acute monocytic leukemia. A study of 12 cases. (304666)
1977
48
Acute monocytic leukemia. Cytologic, histologic, cytochemical, ultrastructural, and cytogenetic observations. (57715)
1976
49
SYNDROME OF ERYTHREMIA DI GUGLIELMO AFTER LIGHTNING INJURY WITH AUTOIMMUNE ANTIBODIES AND TERMINATING IN ACUTE MONOCYTIC LEUKEMIA. (14282054)
1965
50
Acute monocytic leukemia responsive to ACTH therapy. (13002763)
1952

Variations for Acute Monocytic Leukemia

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Expression for genes affiliated with Acute Monocytic Leukemia

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Search GEO for disease gene expression data for Acute Monocytic Leukemia.

Pathways for genes affiliated with Acute Monocytic Leukemia

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Pathways related to Acute Monocytic Leukemia according to GeneCards Suite gene sharing:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7EP300, NME1
29.5CSF1, MPO
39.5CSF1, CREBBP
49.5CREBBP, EP300
59.5EP300, CREBBP
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.5CREBBP, EP300
7
Show member pathways
9.5CREBBP, EP300
89.5CREBBP, EP300
9
Show member pathways
FOXA transcription factor networks36
9.5EP300, CREBBP
109.5CREBBP, EP300
119.5CREBBP, EP300
129.5CREBBP, EP300
139.5EP300, CREBBP
14
Show member pathways
p53 pathway36
9.5CREBBP, EP300
159.5CREBBP, EP300
16
Show member pathways
9.5EP300, CREBBP
17
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling58
9.5EP300, CREBBP
189.5EP300, CREBBP
199.5EP300, CREBBP
209.5EP300, CREBBP
21
Show member pathways
DNA damage Role of SUMO in p53 regulation58
9.5EP300, CREBBP
22
Show member pathways
9.5CREBBP, EP300
239.5CREBBP, EP300
249.5EP300, CREBBP
25
Show member pathways
IFN-gamma pathway36
9.5CREBBP, EP300
269.5EP300, CREBBP
279.5CREBBP, EP300
289.5EP300, CREBBP
299.5CREBBP, EP300
30
Show member pathways
9.5CREBBP, EP300
31
Show member pathways
9.5CREBBP, EP300
329.5EP300, CREBBP
339.5EP300, CREBBP
349.5CREBBP, EP300
359.5CD14, CD40
369.2EP300, THBD
379.2EP300, CREBBP, NME1
389.2EP300, CREBBP, NME1
399.1EP300, CREBBP, CD14
40
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.1EP300, CREBBP, CD14
41
Show member pathways
9.1CD14, CREBBP, EP300
429.0CREBBP, EP300, MPO
439.0MPO, CD14, CD40
44
Show member pathways
8.9EP300, CREBBP, CD40
458.9CD40, CREBBP, EP300
468.9CD40, CREBBP, EP300
478.9CD40, CREBBP, EP300
48
Show member pathways
8.7CREBBP, EP300, THBD
49
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.5EP300, CREBBP, CD14, CD40
50
Show member pathways
8.1CD40, CD14, CREBBP, CSF1, EP300

Compounds for genes affiliated with Acute Monocytic Leukemia

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Compounds related to Acute Monocytic Leukemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate439.6CD14, MPO
2mitoxantrone43 49 1211.4MPO, CSF1, CREBBP
3etoposide43 49 59 1212.1CREBBP, CSF1, EP300, NME1
45fluorouracil439.0NME1, CREBBP, CSF1, MPO
5pentoxifylline43 1210.0MPO, CD14, THBD
6n-formylmethionyl-leucylphenylalanine439.0MPO, CSF1, THBD
7p003438.9CSF1, CREBBP, CD40, CD14
8mannose438.9CREBBP, CD14, CD40, CSF1
9rantes438.9CREBBP, CD14, CD40, CSF1
10ly294002438.9CD40, CD14, EP300, CSF1
11wortmannin438.9CSF1, CD14, CD40, EP300
12glutamine438.8CD14, NME1, CREBBP, EP300
13dmso438.7MPO, NME1, CSF1, THBD
14carboplatin43 49 1210.7CREBBP, CSF1, MPO
15doxorubicin43 49 1210.7CREBBP, CD40, CSF1, EP300
16neopterin438.7CSF1, CD40, THBD, CD14
17dbc-amp438.7CREBBP, THBD, CD14
18cisplatin43 49 59 1211.6NME1, MPO, EP300, CREBBP, CSF1
19vitamin d438.6CREBBP, CD14, THBD, EP300
20calcitriol43 59 24 1211.5THBD, EP300, CSF1, NME1, CD14
21pd 98,059438.5CD40, CD14, CREBBP, CSF1, EP300
22chloramphenicol43 2 49 1211.5THBD, CSF1, CD40, MPO
23aspartate438.4NME1, THBD, EP300, CSF1, CD14
24superoxide43 249.4CD40, CD14, CREBBP, CSF1, MPO
25phosphatidylinositol438.4CD14, CREBBP, CD40, EP300, CSF1
26lactate438.4THBD, MPO, CSF1, NME1, CD14
27actinomycin d438.3CD40, CSF1, EP300, THBD
28retinoid438.3THBD, EP300, CSF1, CREBBP, CD14
29dexamethasone43 49 28 1211.2CD40, CSF1, CD14, THBD, NME1
30arginine438.2CREBBP, THBD, CSF1, CD14, EP300
31prednisolone43 28 1210.2MPO, THBD, CD40, CD14, CSF1
32forskolin43 49 1210.1CD40, CD14, THBD, CREBBP
33histamine43 28 2410.1CSF1, THBD, MPO, CD40, CD14
34estrogen438.1NME1, CREBBP, EP300, CSF1, THBD
35atp43 289.1THBD, EP300, CREBBP, NME1, CD14
36butyrate438.0MPO, CD40, EP300, CSF1, CREBBP, CD14
37cyclophosphamide43 49 1210.0THBD, MPO, CSF1, CREBBP, CD40
38alanine437.9CD14, NME1, CSF1, EP300, CREBBP, THBD
39paraffin437.8NME1, THBD, CSF1, MPO, CD14, CD40
40glucose437.8CD14, CREBBP, CD40, EP300, THBD
41steroid437.8NME1, THBD, EP300, CD14, CD40, CREBBP
42progesterone43 28 59 24 1211.7NME1, CREBBP, CSF1, EP300, THBD, CD40
43pge2437.7CREBBP, NME1, CD14, CD40, CSF1, EP300
44tyrosine437.6CD40, CSF1, THBD, EP300, NME1, CREBBP
45nitric oxide43 24 129.6MPO, EP300, CREBBP, NME1, CD40, THBD
46cysteine437.4CSF1, CD40, CD14, NME1, CREBBP, EP300
47creatinine436.9EP300, THBD, CD40, CD14, NME1, CREBBP
48vegf436.9THBD, CD14, NME1, CREBBP, CSF1, EP300
49retinoic acid43 247.8CSF1, CREBBP, NME1, CD14, CD40, MPO
50serine436.8THBD, CD40, CD14, NME1, CREBBP, CSF1

GO Terms for genes affiliated with Acute Monocytic Leukemia

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Cellular components related to Acute Monocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase complexGO:00001239.5CREBBP, EP300
2extracellular spaceGO:00056157.4CD40, CD14, CSF1, MPO, THBD

Biological processes related to Acute Monocytic Leukemia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA bindingGO:00433889.8NME1, EP300
2response to tumor necrosis factorGO:00346129.8CD14, EP300
3N-terminal peptidyl-lysine acetylationGO:00180769.7CREBBP, EP300
4regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:00614189.6EP300, CREBBP
5cellular response to lipopolysaccharideGO:00712229.5CD40, CD14
6response to cAMPGO:00515919.2THBD, NME1
7positive regulation of type I interferon productionGO:00324819.2CREBBP, EP300
8inflammatory responseGO:00069549.1CD40, CD14, CSF1
9innate immune responseGO:00450878.9EP300, CSF1, CREBBP, CD14

Molecular functions related to Acute Monocytic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:00164079.6CREBBP, EP300
2RNA polymerase II activating transcription factor bindingGO:00011029.6CREBBP, EP300
3histone acetyltransferase activityGO:00044029.4CREBBP, EP300
4antigen bindingGO:00038239.4CD40, EP300
5p53 bindingGO:00020399.2CREBBP, EP300
6chromatin bindingGO:00036829.0MPO, EP300, CREBBP

Products for genes affiliated with Acute Monocytic Leukemia

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Sources for Acute Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet