MCID: ACT009
MIFTS: 61

Acute Monocytic Leukemia malady

Blood diseases, Cancer diseases categories

Summaries for Acute Monocytic Leukemia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia. more...

MalaCards: Acute Monocytic Leukemia, also known as acute monoblastic leukemia, is related to monocytic leukemia and acute leukemia. An important gene associated with Acute Monocytic Leukemia is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are LDL Oxidation in Atherogenesis and LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and skin, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Description from OMIM:46 151380

Aliases & Classifications for Acute Monocytic Leukemia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 46OMIM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
acute monocytic leukemia:
Prevalence: 1-9/1000000; Age of onset: Childhood


Aliases & Descriptions:

acute monocytic leukemia 8 10 44 48 30 60
acute monoblastic leukemia 8 42 48 60
acute monoblastic leukemia and acute monocytic leukemia 8
acute monocytic leukemia without mention of remission 8
acute monocytic leukemia, morphology 8
acute myeloblastic leukemia type 5 48
acute monocytic leukemia, fab m5 8
acute monocytic leukaemia 8
aml-m5 48


External Ids:

Disease Ontology8 DOID:8864
ICD9CM27 206.0
NCIt39 C7318
OMIM46 151380
MeSH34 D007948
MESH via Orphanet35 D007948
ICD10 via Orphanet26 C92.7
SNOMED-CT via Orphanet57 277601005, 278170009, 413441006 22331004, 413442004, more
UMLS via Orphanet61 C0457334, C1318544

Related Diseases for Acute Monocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Monocytic Leukemia family:

Chronic Monocytic Leukemia Subacute Monocytic Leukemia
Monocytic Leukemia

Diseases related to Acute Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1monocytic leukemia31.9KAT6A, CSF1, CRAT, CD40, CD14, EP300
2acute leukemia31.9CSF1, RARA, KMT2A, HOXA9, CD14, NUP98
3leukemia31.9MLLT10, MPO, NUP98, CD40, CD14, EP300
4disseminated intravascular coagulation30.5CD14, RARA, THBD
5sarcoma30.5CSF1, EP300
6acute lymphocytic leukemia30.5CREBBP, MLLT10, MPO, CD40, EP300, HOXA9
7myeloid leukemia30.5CSF1, CREBBP, CRAT, MLLT10, MPO, NUP98
8myeloid sarcoma30.3KMT2A, MPO
9hepatocellular carcinoma30.1RARA, NME1, CD14, CRAT
10myeloma30.1RARA, CD14, CD40, CSF1
11neutropenia30.1CD40, MPO, CSF1
12t-cell leukemia30.1EP300, CD40, CRAT, CREBBP
13acute myeloblastic leukemia type 510.5
14childhood leukemia10.4
15acute t cell leukemia10.4
16histiocytosis10.4
17acute myeloid leukemia10.3
18testicular leukemia10.2
19central nervous system leukemia10.2
20infectious mononucleosis10.2
21chronic monocytic leukemia10.2
22aleukemic monocytic leukemia cutis10.2
23aleukemic leukemia cutis10.2
24gingivitis10.2
25lymphoblastic leukemia10.2
26respiratory failure10.2
27ichthyosis vulgaris10.2
28klinefelter's syndrome10.2
29duchenne muscular dystrophy10.2
30brachial plexus neuropathy10.2
31muscular dystrophy10.2
32neuropathy10.2
33osteosclerosis10.2
34rhabdomyosarcoma10.2
35gingival hypertrophy10.1
36neurofibromatosis10.1
37non-hodgkin lymphoma10.1
38macroglobulinemia10.1
39severe congenital neutropenia10.1
40diabetes insipidus10.1
41hemoglobinuria10.1
42natural killer cell leukemia10.1
43leukostasis10.1
44malignant histiocytosis10.1
45down syndrome10.1
46protein c deficiency10.1
47aplastic anemia10.1
48chromosomal disease10.1
49chronic lymphocytic leukemia10.1
50hepatitis10.1

Graphical network of the top 20 diseases related to Acute Monocytic Leukemia:



Diseases related to acute monocytic leukemia

Clinical Features for Acute Monocytic Leukemia

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46OMIM
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Clinical features from OMIM:

151380

Drugs & Therapeutics for Acute Monocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Monocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Monocytic Leukemia

Search NIH Clinical Center for Acute Monocytic Leukemia

Search CenterWatch for Acute Monocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Monocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Monocytic Leukemia:
NiCord
Embryonic/Adult Cultured Cells Related to Acute Monocytic Leukemia:
Umbilical cord blood-derived stem cells (NiCord), PMID: 22198152

Genetic Tests for Acute Monocytic Leukemia

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Anatomical Context for Acute Monocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute Monocytic Leukemia:

32
Monocytes, Myeloid, Skin, Bone, Bone marrow, B cells, T cells, Liver, Spinal cord, Testes, Spleen, Endothelial

Animal Models for Acute Monocytic Leukemia or affiliated genes

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36MGI
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Publications for Acute Monocytic Leukemia

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Sources:
50PubMed
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Articles related to Acute Monocytic Leukemia:

(show top 50)    (show all 299)
idTitleAuthorsYear
1
The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1. (24121275)
2013
2
The need for continuing chemotherapy for leukemic cell lysis pneumopathy in patients with acute myelomonocytic/monocytic leukemia. (23728559)
2013
3
Fatal bronchial invasion of Scopulariopsis brevicaulis in an acute monocytic leukemia patient. (22633337)
2012
4
The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells. (23096114)
2012
5
Effect of RNAi-induced down regulation of nuclear factor kappa-B p65 on acute monocytic leukemia THP-1 cells in vitro and vivo. (21901538)
2012
6
Heterogeneous leukemic clones identified by NPM1 mutation analysis in patient with acute monocytic leukemia. (22035378)
2012
7
Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia. (21617233)
2011
8
Quantitative assessment of MLAA-34 expression in diagnosis and prognosis of acute monocytic leukemia. (21240483)
2011
9
The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. (20138666)
2010
10
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia. (17972946)
2008
11
Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes. (18790773)
2008
12
Leukemia cutis in a patient with acute monocytic leukemia presenting as unique facial erythema. (19017048)
2008
13
A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. (17656258)
2007
14
Spontaneous remission of acute monocytic leukemia after infection with Clostridium septicum. (17824921)
2007
15
Indoleamine 2, 3-dioxygenase expression in cells of human acute monocyte leukemia (M(5)) and acute lymphocyte leukemia and therapeutic effect of its inhibitor 1-methyl tryptophan. (17605849)
2007
16
Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15. (16826222)
2006
17
Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. (16518848)
2006
18
Acute monocytic leukemia (French-American-British classification M5) does not have a worse prognosis than other subtypes of acute myeloid leukemia: a report from the Eastern Cooperative Oncology Group. (14970186)
2004
19
MLL/GRAF fusion in an infant acute monocytic leukemia (AML M5b) with a cytogenetically cryptic ins(5;11)(q31;q23q23). (15382263)
2004
20
Simultaneous presentation of multiple myeloma and acute monocytic leukemia. (14567751)
2003
21
Atypical generalized eruptive histiocytosis associated with acute monocytic leukemia. (14576638)
2003
22
Light chain proteinuria and lysozymuria in a patient with acute monocytic leukemia. (12089194)
2002
23
Cloning and characterization of a novel zinc finger protein (MDZF) that is associated with monocytic differentiation of acute promyelocytic leukemia cells. (11710595)
2001
24
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (10824998)
2000
25
Tetrasomy 8 evolving into a segmental triplication 8q in a case of acute monocytic leukemia. (10616537)
2000
26
Fluorescence in situ hybridization characterization of the chromosomal breakpoints in a case with ins(17;3)(q11.2;q21q26.3) and acute monocytic leukemia. (9797776)
1998
27
Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia]. (10743082)
1997
28
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23). (9305600)
1997
29
Double isochromosome 8q as single cytogenetic aberration in acute myelo-monocytic leukemia. (8535230)
1995
30
Third case of acute monocytic leukemia (M5) occurring in an HIV-seropositive man: a case report. (7639286)
1995
31
Monocytic differentiation of acute promyelocytic leukemia cells in response to 1,25-dihydroxyvitamin D3 is independent of nuclear receptor binding. (7608152)
1995
32
A case of acute monocytic leukemia with t(11;17) involving a rearrangement of MLL-1 and a region proximal to the RARA gene. (8194047)
1994
33
Synthesis and regulation of complement components by human monocytes/macrophages and by acute monocytic leukemia. (8517928)
1993
34
Intracerebral chloroma complicating acute monocytic leukemia. (1603221)
1992
35
Acute monocytic leukemia with chloroacetate esterase positivity. FAB M4 or M5? (1615924)
1992
36
Orbital tumor in an infant with acute monocytic leukemia associated with chromosome 5q-,t(9p-11q+),11p+. (1762721)
1991
37
An unusual chromosome aberration 47,XX,+21,dup(12)(q13----q24),dup(12)(q13----q24) in a girl with Down syndrome and acute monocytic leukemia. (1833047)
1991
38
In situ hybridization ascertains the presence of a translocation t(6;11) in an acute monocytic leukemia. (2268582)
1990
39
Early deaths due to hemorrhage and leukostasis in childhood acute myelogenous leukemia. Associations with hyperleukocytosis and acute monocytic leukemia. (3479232)
1987
40
Identification of monocytic nature in acute undifferentiated leukemia by in vitro marrow culture study. (3635419)
1986
41
Translocation X;10 in a case of congenital acute monocytic leukemia. (3856472)
1985
42
Defective mechanisms of immunophagocytosis by leukemic monocytes in childhood acute monocytic leukemia demonstrated by electron microscopy. (6594894)
1984
43
Interleukin 1 production by a human acute monocytic leukemia cell line. (6309415)
1983
44
Phenotypic change of acute monocytic leukemia to acute lymphoblastic leukemia on therapy. (6584045)
1983
45
Acute monocytic leukemia complicating combined-modality therapy for localized childhood Ewing's sarcoma. (6949907)
1981
46
Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). (6970727)
1980
47
Therapeutic leukopheresis of acute myelo-monocytic leukemia in pregnancy. (272483)
1978
48
Monocytic leukemia as a cause of acute respiratory obstruction. (4521037)
1974
49
Acute monocytic leukemia in pregnancy. Report of a case treated with 6-mercaptopurine in the first trimester. (19777624)
1963
50
Acute monocytic leukemia; a case report. (20988154)
1946

Genetic Variations for Acute Monocytic Leukemia

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Expression for genes affiliated with Acute Monocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Monocytic Leukemia

Search GEO for disease gene expression data for Acute Monocytic Leukemia.

Pathways for genes affiliated with Acute Monocytic Leukemia

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Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MPO, CSF1
210.4EP300, CREBBP
310.4EP300, CREBBP
410.3CREBBP, EP300, NME1
510.3EP300, MPO, CREBBP
610.3CREBBP, CD40, EP300
7
Hide members
10.3RARA, EP300, CREBBP
8
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
10.3CREBBP, EP300, RARA
9
Hide members
10.2CREBBP, CD40, CD14, EP300
1010.2CREBBP, EP300, NME1, RARA
11
Hide members
10.1CSF1, CREBBP, CD40, CD14, EP300, RARA
1210.1RARA, KMT2A, HOXA9, CD14, CD40, MPO

Compounds for genes affiliated with Acute Monocytic Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1pge24410.8CRAT
2estrogen4410.8KMT2A
3butyrate4410.7CSF1, CRAT, CD40
4cyclophosphamide44 49 1112.7CREBBP, CD40, THBD
5aspartate4410.6CRAT, CD14, NME1, KMT2A
6p0034410.6CSF1, CREBBP
7pentoxifylline44 1111.6CRAT, MPO, CD14, THBD
8neopterin4410.6CSF1, CD40, CD14, THBD
9dbc-amp4410.6CREBBP, CRAT, CD14, THBD
10prednisolone44 28 1112.5CSF1, MPO, CD40, CD14, KMT2A, THBD
11dexamethasone44 49 28 1113.5CRAT, LTB4R, CD14, NME1, RARA
12paclitaxel44 49 1112.5CSF1, CRAT, RARA
13creatinine4410.5CSF1, CREBBP, CRAT, CD14, EP300, NME1
14chloramphenicol44 2 1112.5CSF1, CRAT, MPO, CD40, RARA, THBD
151,25 dihydroxy vitamin d34410.5RARA, CD14, CRAT, CSF1
16calcitriol44 59 11 2413.5CSF1, CD14, EP300, NME1, KMT2A, RARA
17pd 98,0594410.5CSF1, CREBBP, CD40, CD14, EP300, RARA
18polyinosinic-polycytidylic acid4410.5CD40, CRAT, CSF1
19vitamin d4410.5CREBBP, CRAT, CD14, EP300, RARA, THBD
20paraffin4410.5CSF1, MPO, CD40, CD14, NME1, RARA
21retinoid4410.5CSF1, CREBBP, CRAT, CD14, EP300, RARA
22serine4410.5CSF1, CREBBP, MPO, EP300, NME1, KMT2A
23etoposide44 49 59 1113.5CSF1, CREBBP, CRAT, EP300, NME1, KMT2A
24doxorubicin44 49 1112.5CSF1, CREBBP, CRAT, CD40, EP300, KMT2A
25lactate4410.4CSF1, CRAT, MPO, CD14, NME1, THBD
26actinomycin d4410.4CSF1, CRAT, CD40, EP300, KMT2A, RARA
27histamine44 28 2412.4THBD, CD14, CD40, MPO, CSF1
28mannose4410.4CSF1, CREBBP, CD40, CD14
29cisplatin44 49 59 1113.4CSF1, CREBBP, CRAT, MPO, EP300, NME1
30superoxide44 2411.4CSF1, CREBBP, MPO, LTB4R, CD40, CD14
31ly2940024410.4CSF1, CD40, CD14, EP300, RARA
32progesterone44 59 28 11 2414.4CSF1, CREBBP, CRAT, CD40, EP300, NME1
33steroid4410.4CREBBP, CRAT, CD40, CD14, EP300, NME1
34alanine4410.4CSF1, CREBBP, LTB4R, CD14, EP300, NME1
35arginine4410.4CSF1, CREBBP, CRAT, CD14, EP300, KMT2A
36oligonucleotide4410.4CRAT, NUP98, CD40, CD14, NME1, KMT2A
37cysteine4410.3CSF1, CREBBP, CD40, CD14, EP300, NME1
38fmlp4410.3CSF1, MPO, LTB4R, CD14
39nitric oxide44 11 2412.3CREBBP, CRAT, MPO, LTB4R, CD40, EP300
40vegf4410.3CSF1, CREBBP, CRAT, MPO, CD40, CD14
41zinc44 2411.3KAT6A, CREBBP, CRAT, MLLT10, CD40, EP300
42forskolin44 49 1112.3THBD, CD14, CD40, CRAT, CREBBP
43mitoxantrone44 49 1112.3CSF1, CREBBP, MPO
44atp44 2811.3CREBBP, CRAT, LTB4R, CD14, EP300, NME1
45ch 554410.2THBD, RARA
46gtp44 2811.2KMT2A, NME1, CD14, NUP98, CRAT
47prostaglandin4410.2CD40, LTB4R, CRAT, CSF1
48tyrosine4410.2CSF1, CREBBP, CD40, EP300, HOXA9, NME1
49retinoic acid44 2411.2THBD, CSF1, CREBBP, CRAT, MPO, LTB4R
50alpha-naphthyl butyrate4410.1CD14, MPO

GO Terms for genes affiliated with Acute Monocytic Leukemia

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Sources:
16Gene Ontology
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Biological processes related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.2CD14, CD40, LTB4R, CSF1
2N-terminal peptidyl-lysine acetylationGO:01807610.1EP300, CREBBP

Molecular functions related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:01640710.4EP300, CREBBP, KAT6A
2histone acetyltransferase activityGO:00440210.3EP300, CREBBP, KAT6A
3transcription factor bindingGO:00813410.2RARA, EP300, CREBBP, KAT6A
4chromatin bindingGO:00368210.2KAT6A, CREBBP, MPO, EP300, KMT2A
5transcription coactivator activityGO:0037139.9KAT6A, CREBBP, EP300, RARA
6zinc ion bindingGO:0082709.9KAT6A, CREBBP, MLLT6, MLLT10, EP300, KMT2A
7protein bindingGO:0055159.6NUP98, MYH7B, MLLT10, MLLT6, CREBBP, KAT6A

Products for genes affiliated with Acute Monocytic Leukemia

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  • Antibodies
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Sources for Acute Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet