MCID: ACT009
MIFTS: 61

Acute Monocytic Leukemia malady

Blood diseases, Cancer diseases categories

Summaries for Acute Monocytic Leukemia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia. more...

MalaCards: Acute Monocytic Leukemia, also known as acute monoblastic leukemia, is related to monocytic leukemia and acute leukemia. An important gene associated with Acute Monocytic Leukemia is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are LDL Oxidation in Atherogenesis and LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Description from OMIM:46 151380

Aliases & Classifications for Acute Monocytic Leukemia

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 27ICD9CM, 39NCIt, 46OMIM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
acute monocytic leukemia:
Prevalence: 1-9/1000000; Age of onset: Childhood


Aliases & Descriptions:

acute monocytic leukemia 8 10 44 48 30 60
acute monoblastic leukemia 8 42 48 60
acute monoblastic leukemia and acute monocytic leukemia 8
acute monocytic leukemia without mention of remission 8
acute monocytic leukemia, morphology 8
acute myeloblastic leukemia type 5 48
acute monocytic leukemia, fab m5 8
acute monocytic leukaemia 8
aml-m5 48


External Ids:

Disease Ontology8 DOID:8864
ICD9CM27 206.0
NCIt39 C7318
OMIM46 151380
MeSH34 D007948
MESH via Orphanet35 D007948
ICD10 via Orphanet26 C92.7
SNOMED-CT via Orphanet57 277601005, 278170009, 413441006 22331004, 413442004, more
UMLS via Orphanet61 C0457334, C1318544

Related Diseases for Acute Monocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Monocytic Leukemia family:

Chronic Monocytic Leukemia Subacute Monocytic Leukemia
Monocytic Leukemia

Diseases related to Acute Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1monocytic leukemia31.9KAT6A, CSF1, CRAT, CD40, CD14, EP300
2acute leukemia31.9CSF1, RARA, KMT2A, HOXA9, CD14, NUP98
3leukemia31.9MLLT10, MPO, NUP98, CD40, CD14, EP300
4disseminated intravascular coagulation30.5CD14, RARA, THBD
5sarcoma30.5CSF1, EP300
6acute lymphocytic leukemia30.5CREBBP, MLLT10, MPO, CD40, EP300, HOXA9
7myeloid leukemia30.5CSF1, CREBBP, CRAT, MLLT10, MPO, NUP98
8myeloid sarcoma30.3KMT2A, MPO
9hepatocellular carcinoma30.1RARA, NME1, CD14, CRAT
10myeloma30.1RARA, CD14, CD40, CSF1
11neutropenia30.1CD40, MPO, CSF1
12t-cell leukemia30.1EP300, CD40, CRAT, CREBBP
13acute myeloblastic leukemia type 510.5
14childhood leukemia10.4
15acute t cell leukemia10.4
16histiocytosis10.4
17acute myeloid leukemia10.3
18testicular leukemia10.2
19central nervous system leukemia10.2
20infectious mononucleosis10.2
21chronic monocytic leukemia10.2
22aleukemic monocytic leukemia cutis10.2
23aleukemic leukemia cutis10.2
24gingivitis10.2
25lymphoblastic leukemia10.2
26respiratory failure10.2
27ichthyosis vulgaris10.2
28klinefelter's syndrome10.2
29duchenne muscular dystrophy10.2
30brachial plexus neuropathy10.2
31muscular dystrophy10.2
32neuropathy10.2
33osteosclerosis10.2
34rhabdomyosarcoma10.2
35gingival hypertrophy10.1
36neurofibromatosis10.1
37non-hodgkin lymphoma10.1
38macroglobulinemia10.1
39severe congenital neutropenia10.1
40diabetes insipidus10.1
41hemoglobinuria10.1
42natural killer cell leukemia10.1
43leukostasis10.1
44malignant histiocytosis10.1
45down syndrome10.1
46protein c deficiency10.1
47aplastic anemia10.1
48chromosomal disease10.1
49chronic lymphocytic leukemia10.1
50hepatitis10.1

Graphical network of the top 20 diseases related to Acute Monocytic Leukemia:



Diseases related to acute monocytic leukemia

Clinical Features for Acute Monocytic Leukemia

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Sources:
46OMIM
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Clinical features from OMIM:

151380

Drugs & Therapeutics for Acute Monocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Monocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Monocytic Leukemia

Search NIH Clinical Center for Acute Monocytic Leukemia

Search CenterWatch for Acute Monocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Monocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Monocytic Leukemia:
NiCord
Embryonic/Adult Cultured Cells Related to Acute Monocytic Leukemia:
Umbilical cord blood-derived stem cells (NiCord), PMID: 22198152

Genetic Tests for Acute Monocytic Leukemia

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Anatomical Context for Acute Monocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute Monocytic Leukemia:

32
Monocytes, Myeloid, Bone, Skin, Bone marrow, B cells, T cells, Spinal cord, Liver, Testes, Spleen, Endothelial

Animal Models for Acute Monocytic Leukemia or affiliated genes

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36MGI
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Publications for Acute Monocytic Leukemia

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Sources:
50PubMed
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Articles related to Acute Monocytic Leukemia:

(show top 50)    (show all 299)
idTitleAuthorsYear
1
Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation. (23027709)
2013
2
Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1. (22179005)
2011
3
Successful treatment of acute monocytic leukemia with intracranial hemorrhage as the first manifestation. (20958870)
2010
4
A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia. (20471517)
2010
5
Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (18592235)
2009
6
Expression of genes psma6 and slc25a4 in patients with acute monocytic leukemia]. (19840444)
2009
7
Bioinformatic analysis and identification for a novel antigen MLAA-22 in acute monocytic leukemia]. (18549609)
2008
8
CD163: a specific immunohistochemical marker for acute myeloid leukemia with monocytic differentiation. (18542032)
2008
9
Impairment of granulo-monocytic development of human common myeloid progenitors but not of granulo-monocytic progenitors by decreasing stem cell leukemia/T-cell acute leukemia 1 expression. (18436863)
2008
10
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. (18782972)
2008
11
Effects of FMS-like tyrosine kinase 3 targeted RNA interference on proliferation and apoptosis of acute monocytic leukemia cell line THP-1]. (18021537)
2007
12
Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. (17446561)
2007
13
A unique case of acute promyelocytic leukemia showing monocytic differentiation after ATRA (all-trans retinoic acid) therapy. (16405439)
2006
14
Comparison of cytogenetics and clinical manifestations between M5a and M5b of acute monocytic leukemia. (16928293)
2006
15
The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22. (15897884)
2005
16
Impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia. (15972121)
2005
17
Flow cytometry immunophenotypic characteristics of monocytic population in acute monocytic leukemia (AML-M5), acute myelomonocytic leukemia (AML-M4), and chronic myelomonocytic leukemia (CMML). (15603447)
2004
18
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
19
Mononucleosis syndrome and acute monocytic leukemia. (12071940)
2002
20
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. (11243405)
2001
21
Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia. (11604555)
2001
22
Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b). (11530805)
2001
23
Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia. (10905060)
2000
24
Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22. (11150605)
2000
25
Analysis of MLL-derived transcripts in infant acute monocytic leukemia with a complex translocation (1;11;4)(q21;q23;p16). (10700861)
2000
26
Spurious elevation of automated platelet counts in secondary acute monocytic leukemia associated with tumor lysis syndrome. (10539919)
1999
27
Acute monocytic leukemia presenting as cutaneous involvement. (10640848)
1999
28
Effective treatment of thymic carcinoma with operation and combination chemotherapy against acute monocyte leukemia: case report and review of the literature. (9793029)
1998
29
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. (8667638)
1996
30
Hepatosplenic abscess caused by Curvularia boedijn in a patient with acute monocytic leukemia. (8970227)
1996
31
t(1;19)(q23;p13) in a case of acute monocytic leukemia. (8646742)
1996
32
Heavy-chain immunoglobulin gene rearrangement and cytoplasmic immunoglobulin expression in acute monocytic leukemia following primary germ cell tumor. (7533544)
1995
33
Acute monocytic leukemia: a myeloid leukemia subset that may be sensitive to methotrexate. (7532768)
1995
34
Acute monocytic leukemia with chloroacetate esterase positivity: FAB M4 or M5? (8240517)
1993
35
Chromosome painting in acute monocytic leukemia. (7680885)
1993
36
Establishment of a monocytoid cell line (DOP-M1) from an infant with acute monocytic leukemia. (1581583)
1992
37
"Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia. (1993304)
1991
38
Secretion of an interleukin 1-like activity by acute monocytic leukemia cells which inhibits growth of fibroblasts. (1966989)
1990
39
Tumor necrosis factor alpha down-regulates c-myc mRNA expression and induces in vitro monocytic differentiation in fresh blast cells from patients with acute myeloblastic leukemia. (2359342)
1990
40
An unusual presentation of acute monocytic leukemia: a case report. (3253268)
1988
41
Inv(16) occurring in a case of acute biphenotypic leukemia lacking monocytic markers: multiple but short remissions. (3470123)
1987
42
Monocytoid reaction due to cytomegalovirus infection in acute monocytic leukemia. (2856361)
1987
43
Interferon and c-ets-1 genes in the translocation (9;11)(p22;q23) in human acute monocytic leukemia. (3455787)
1986
44
A possible specific chromosome marker for monocytic leukemia: three more patients with t(9;11)(p22;q24) and another with t(11;17)(q24;q21), each with acute monoblastic leukemia. (6572092)
1983
45
Central nervous system involvement as a presenting feature of acute monocytic leukemia: preceding leukemia by 12 months. (6576628)
1983
46
Bone involvement in acute monocytic leukemia. (6407924)
1983
47
Isolation of novel glycoprotein HNC1beta from the urine of a patient with acute monocytic leukemia. (272227)
1978
48
An extra small acrocentric chromosome in a case of acute monocytic leukemia. (5213033)
1965
49
Leukopenic infectious monocytosis. Report of a case closely simulating acute monocytic leukemia. (13984381)
1963
50
Acute monocytic leukemia in childhood. (13199514)
1954

Genetic Variations for Acute Monocytic Leukemia

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Expression for genes affiliated with Acute Monocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Monocytic Leukemia

Search GEO for disease gene expression data for Acute Monocytic Leukemia.

Pathways for genes affiliated with Acute Monocytic Leukemia

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Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4MPO, CSF1
210.4EP300, CREBBP
310.4EP300, CREBBP
410.3CREBBP, EP300, NME1
510.3EP300, MPO, CREBBP
610.3CREBBP, CD40, EP300
7
Hide members
10.3RARA, EP300, CREBBP
8
Development Ligand-dependent activation of the ESR1/AP-1 pathway
Hide members
10.3CREBBP, EP300, RARA
9
Hide members
10.2CREBBP, CD40, CD14, EP300
1010.2CREBBP, EP300, NME1, RARA
11
Hide members
10.1CSF1, CREBBP, CD40, CD14, EP300, RARA
1210.1RARA, KMT2A, HOXA9, CD14, CD40, MPO

Compounds for genes affiliated with Acute Monocytic Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1pge24410.8CRAT
2estrogen4410.8KMT2A
3butyrate4410.7CSF1, CD40, CRAT
4cyclophosphamide44 49 1112.7CREBBP, THBD, CD40
5aspartate4410.6CRAT, CD14, NME1, KMT2A
6p0034410.6CREBBP, CSF1
7pentoxifylline44 1111.6CRAT, THBD, CD14, MPO
8neopterin4410.6CSF1, THBD, CD14, CD40
9prednisolone44 28 1112.5CD40, THBD, CD14, CSF1, MPO, KMT2A
10dbc-amp4410.5THBD, CREBBP, CRAT, CD14
11dexamethasone44 49 28 1113.5CRAT, NME1, CD14, RARA, LTB4R
12paclitaxel44 49 1112.5RARA, CRAT, CSF1
13creatinine4410.5EP300, THBD, CREBBP, CSF1, NME1, CRAT
14chloramphenicol44 2 1112.5CRAT, THBD, RARA, CD40, MPO, CSF1
151,25 dihydroxy vitamin d34410.5CSF1, RARA, CD14, CRAT
16calcitriol44 59 11 2413.5CSF1, CD14, NME1, KMT2A, RARA, EP300
17pd 98,0594410.5RARA, CD40, EP300, CD14, CSF1, CREBBP
18polyinosinic-polycytidylic acid4410.5CSF1, CD40, CRAT
19vitamin d4410.5CREBBP, CRAT, CD14, EP300, RARA, THBD
20paraffin4410.5CSF1, MPO, CD40, CD14, NME1, RARA
21retinoid4410.5CSF1, CREBBP, CRAT, CD14, THBD, EP300
22serine4410.5KMT2A, CREBBP, EP300, RARA, NME1, MPO
23etoposide44 49 59 1113.5EP300, CREBBP, NME1, RARA, CSF1, KMT2A
24doxorubicin44 49 1112.5EP300, CSF1, CD40, CRAT, CREBBP, KMT2A
25lactate4410.5CRAT, CSF1, MPO, CD14, NME1, THBD
26actinomycin d4410.4THBD, RARA, KMT2A, EP300, CRAT, CD40
27histamine44 28 2412.4CSF1, CD14, MPO, CD40, THBD
28mannose4410.4CD14, CREBBP, CD40, CSF1
29cisplatin44 49 59 1113.4NME1, EP300, CSF1, CREBBP, CRAT, MPO
30superoxide44 2411.4CD40, LTB4R, MPO, CREBBP, CD14, CSF1
31ly2940024410.4CSF1, RARA, EP300, CD14, CD40
32progesterone44 59 28 11 2414.4CRAT, THBD, RARA, NME1, EP300, CD40
33steroid4410.4NME1, RARA, THBD, CD14, CD40, CRAT
34alanine4410.4CSF1, RARA, NME1, EP300, CD14, LTB4R
35arginine4410.4CREBBP, CRAT, RARA, CSF1, CD14, KMT2A
36oligonucleotide4410.4THBD, NME1, NUP98, RARA, KMT2A, CD14
37cysteine4410.3THBD, RARA, NME1, EP300, CD40, CREBBP
38fmlp4410.3LTB4R, MPO, CSF1, CD14
39nitric oxide44 11 2412.3LTB4R, MPO, CD40, EP300, NME1, RARA
40vegf4410.3RARA, THBD, EP300, CD14, NME1, CSF1
41zinc44 2411.3EP300, CD40, RARA, KMT2A, KAT6A, CREBBP
42forskolin44 49 1112.3CREBBP, CRAT, THBD, CD14, CD40
43mitoxantrone44 49 1112.3MPO, CREBBP, CSF1
44atp44 2811.3CD14, NME1, CRAT, KMT2A, EP300, LTB4R
45alpha-naphthyl butyrate4410.3CD14, MPO
46gtp44 2811.2CRAT, CD14, NME1, KMT2A, NUP98
47prostaglandin4410.2LTB4R, CRAT, CD40, CSF1
48tyrosine4410.2CREBBP, RARA, NME1, KMT2A, EP300, CSF1
49retinoic acid44 2411.2CSF1, CREBBP, CRAT, MPO, LTB4R, CD40
50ch 554410.0RARA, THBD

GO Terms for genes affiliated with Acute Monocytic Leukemia

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16Gene Ontology
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Biological processes related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.2CD14, CD40, LTB4R, CSF1
2N-terminal peptidyl-lysine acetylationGO:01807610.1EP300, CREBBP

Molecular functions related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:01640710.4EP300, CREBBP, KAT6A
2histone acetyltransferase activityGO:00440210.3EP300, CREBBP, KAT6A
3transcription factor bindingGO:00813410.2RARA, EP300, CREBBP, KAT6A
4chromatin bindingGO:00368210.2KAT6A, CREBBP, MPO, EP300, KMT2A
5transcription coactivator activityGO:0037139.9KAT6A, CREBBP, EP300, RARA
6zinc ion bindingGO:0082709.9KAT6A, CREBBP, MLLT6, MLLT10, EP300, KMT2A
7protein bindingGO:0055159.6NUP98, MYH7B, MLLT10, MLLT6, CREBBP, KAT6A

Products for genes affiliated with Acute Monocytic Leukemia

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  • Antibodies
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Sources for Acute Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet