MCID: ACT009
MIFTS: 57

Acute Monocytic Leukemia malady

Cancer diseases category
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Summaries for Acute Monocytic Leukemia

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Wikipedia:65 Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid leukemia. more...

MalaCards based summary: Acute Monocytic Leukemia, also known as acute monoblastic leukemia and acute monocytic leukemia, is related to monocytic leukemia and leukemia. An important gene associated with Acute Monocytic Leukemia is NME1 (NME/NM23 nucleoside diphosphate kinase 1), and among its related pathways are Activation of DNA fragmentation factor and LDL Oxidation in Atherogenesis. The compounds alpha-naphthyl butyrate and mitoxantrone have been mentioned in the context of this disorder. Affiliated tissues include monocytes, myeloid and bone, and related mouse phenotypes are muscle and respiratory system.

Description from OMIM:46 151380

Aliases & Classifications for Acute Monocytic Leukemia

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Acute Monocytic Leukemia, Aliases & Descriptions:

Name: Acute Monocytic Leukemia 30 8 10 44 62
Acute Monoblastic Leukemia and Acute Monocytic Leukemia 8
Acute Monocytic Leukaemia Without Mention of Remission 62
 
Acute Monocytic Leukemia Without Mention of Remission 8
Acute Monocytic Leukemia, Morphology 8
Acute Monocytic Leukemia, Fab M5 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:8864
ICD9CM27 206.0
OMIM46 151380
NCIt39 C7318
MeSH34 D007948

Related Diseases for Acute Monocytic Leukemia

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Diseases in the Acute Monocytic Leukemia family:

Chronic Monocytic Leukemia Subacute Monocytic Leukemia
Monocytic Leukemia

Diseases related to Acute Monocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1monocytic leukemia31.2CSF1, THBD, EP300, CD40, CD14
2leukemia30.9MPO, EP300, CSF1, CREBBP, NME1, CD14
3langerhans-cell histiocytosis30.5CD40, CSF1
4acute myelomonocytic leukemia30.3CSF1, CREBBP, MPO
5severe combined immunodeficiency30.2CSF1, CD40
6myeloma30.2CD14, CD40, CSF1
7neutropenia30.2CD40, MPO, CSF1
8myeloid leukemia30.2CSF1, NME1, MPO, CREBBP, CD14
9acute pancreatitis30.1CD14, MPO
10acute lymphoblastic leukemia30.0CREBBP, CD40, MPO, EP300
11myelodysplastic syndromes30.0MPO, EP300, CSF1, CREBBP
12acute monoblastic leukemia28.9CD14, NME1, CREBBP, CSF1, MPO, THBD
13histiocytosis10.4
14peripheral vascular disease10.4MPO
15sarcoma10.4
16acute myeloid leukemia10.3
17infectious mononucleosis10.3
18aleukemic leukemia cutis10.3
19gingivitis10.3
20lymphoblastic leukemia10.3
21respiratory failure10.3
22cytomegalovirus infection10.3
23germ cell tumors10.3
24rubinstein-taybi syndrome10.2CREBBP, EP300
25pdgfrb-associated chronic eosinophilic leukemia10.2CSF1, MPO
26wegener's granulomatosis10.2CD14, MPO
27arteriosclerosis10.2CD40, CD14
28acute lymphocytic leukemia10.1
29aplastic anemia10.1
30chronic lymphocytic leukemia10.1
31chronic myelomonocytic leukemia10.1
32hepatitis10.1
33hepatocellular carcinoma10.1
34multiple myeloma10.1
35myelofibrosis10.1
36non-hodgkin lymphoma10.1
37paroxysmal nocturnal hemoglobinuria10.1
38severe congenital neutropenia10.1
39nijmegen breakage syndrome10.1
40down syndrome10.1
41leukostasis10.1
42hemoglobinuria10.1
43diabetes insipidus10.1
44testicular leukemia10.1
45macroglobulinemia10.1
46neurofibromatosis10.1
47malignant histiocytosis10.1
48protein c deficiency10.1
49lactic acidosis10.1
50neuroblastoma10.1

Graphical network of the top 20 diseases related to Acute Monocytic Leukemia:



Diseases related to acute monocytic leukemia

Symptoms for Acute Monocytic Leukemia

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Clinical features from OMIM:

151380

Drugs & Therapeutics for Acute Monocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Monocytic Leukemia

Search NIH Clinical Center for Acute Monocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Monocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Acute Monocytic Leukemia:
NiCord
Embryonic/Adult Cultured Cells Related to Acute Monocytic Leukemia:
Umbilical cord blood-derived stem cells (NiCord), PMID: 22198152

Genetic Tests for Acute Monocytic Leukemia

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Anatomical Context for Acute Monocytic Leukemia

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MalaCards organs/tissues related to Acute Monocytic Leukemia:

32
Monocytes, Myeloid, Bone, Bone marrow, Skin, Spinal cord, Liver, B cells, Spleen, Testes, T cells

Animal Models for Acute Monocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute Monocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6MPO, CSF1, CREBBP, EP300
2MP:00053888.0THBD, EP300, CSF1, CREBBP, CD14
3MP:00053787.4CREBBP, NME1, THBD, EP300, CSF1, CD14
4MP:00053857.4CREBBP, CSF1, THBD, MPO, EP300
5MP:00036317.3CD40, NME1, CREBBP, CSF1, EP300, THBD
6MP:00107687.1NME1, CD14, CREBBP, CSF1, EP300, MPO
7MP:00053876.9CD40, CD14, CSF1, EP300, MPO, CREBBP
8MP:00053976.6THBD, MPO, CD40, CD14, NME1, CREBBP
9MP:00053766.6NME1, CD14, CD40, CSF1, EP300, MPO

Publications for Acute Monocytic Leukemia

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Articles related to Acute Monocytic Leukemia:

(show top 50)    (show all 232)
idTitleAuthorsYear
1
Leukemia cutis in a patient with acute monocytic leukemia diagnosed simultaneously with hepatocellular carcinoma: A case study. (24179516)
2013
2
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. (23037626)
2012
3
Role of misfolded N-CoR mediated transcriptional deregulation of Flt3 in acute monocytic leukemia (AML)-M5 subtype. (22514634)
2012
4
Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. (21605636)
2011
5
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. (22187541)
2011
6
Successful treatment of acute monocytic leukemia with intracranial hemorrhage as the first manifestation. (20958870)
2010
7
A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia. (20471517)
2010
8
Effect of epigallocatechin-3-galate on human acute monocytic leukemia cell line U937 and its relevant mechanism]. (20416153)
2010
9
A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25). (18642054)
2008
10
Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes]. (18928586)
2008
11
Bioinformatic analysis and identification for a novel antigen MLAA-22 in acute monocytic leukemia]. (18549609)
2008
12
Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-1 in vitro and subcutaneous tissue of rats in vivo. (16880981)
2005
13
Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21). (16105757)
2005
14
Prognosis of acute monocytic leukemia (French-American-British classification M5). (15718341)
2005
15
Remission of acute monocytic leukemia, secondary to treatment with epipodophyllotoxins, in a patient with t(8;16)(p11;p13) and MYST3-CREBBP fusion. (15262444)
2004
16
Acute monocytic leukemia (French-American-British classification M5) does not have a worse prognosis than other subtypes of acute myeloid leukemia: a report from the Eastern Cooperative Oncology Group. (14970186)
2004
17
Simultaneous presentation of multiple myeloma and acute monocytic leukemia. (14567751)
2003
18
Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia. (12645654)
2003
19
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
20
Light chain proteinuria and lysozymuria in a patient with acute monocytic leukemia. (12089194)
2002
21
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. (11243405)
2001
22
MOZ is fused to p300 in an acute monocytic leukemia with t(8;22). (10824998)
2000
23
Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia. (10905060)
2000
24
Typical CBFbeta/MYH11 fusion due to insertion of the 3'-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22. (11150605)
2000
25
Tetrasomy 8 evolving into a segmental triplication 8q in a case of acute monocytic leukemia. (10616537)
2000
26
Involvement of the MLL and RARalpha genes in a patient with acute monocytic leukemia with t(11;17)(q23;q12) (10720155)
2000
27
Spurious elevation of automated platelet counts in secondary acute monocytic leukemia associated with tumor lysis syndrome. (10539919)
1999
28
Effective treatment of thymic carcinoma with operation and combination chemotherapy against acute monocyte leukemia: case report and review of the literature. (9793029)
1998
29
Identification of a YAC spanning the translocation breakpoint t(8;22) associated with acute monocytic leukemia. (8721686)
1996
30
Infantile acute monocytic leukemia with tumor formation in the skin expressing adhesion molecules as seen by electronmicroscopy. (9021702)
1996
31
Unusual pattern of gastric and hepatic infiltration in an infant with acute monocytic leukemia. (7761154)
1995
32
Acute monocytic leukemia: a single institution experience. (8535217)
1995
33
Heavy-chain immunoglobulin gene rearrangement and cytoplasmic immunoglobulin expression in acute monocytic leukemia following primary germ cell tumor. (7533544)
1995
34
Establishment of a monocytoid cell line (DOP-M1) from an infant with acute monocytic leukemia. (1581583)
1992
35
Intracerebral chloroma complicating acute monocytic leukemia. (1603221)
1992
36
Severe lactic acidosis due to thiamine deficiency after bone marrow transplantation in a child with acute monocytic leukemia. (2129119)
1990
37
Acute monocytic leukemia with B cell markers expression following B chronic lymphocytic leukemia. (2587203)
1989
38
Neurofibromatosis and acute monocytic leukemia in adults. (2507124)
1989
39
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
40
Acute monocytic leukemia in children. Response to VP-16-213 as a single agent. (3326651)
1987
41
Acute monocytic leukemia presenting in the eyelid. An immunohistochemical and electron microscopic study. (3468454)
1986
42
Defective mechanisms of immunophagocytosis by leukemic monocytes in childhood acute monocytic leukemia demonstrated by electron microscopy. (6594894)
1984
43
Acute monocytic leukemia: a surface marker study. (6951407)
1982
44
Acute monocytic leukemia complicating combined-modality therapy for localized childhood Ewing's sarcoma. (6949907)
1981
45
Electron microscopic studies on leukemic cells in suspension culture in childhood acute monocytic leukemia. (284701)
1979
46
Positive monospot tests preceding the diagnosis of acute monocytic leukemia in two adolescents. (275531)
1978
47
Pure acute monocytic leukemia. A study of 12 cases. (304666)
1977
48
Acute monocytic leukemia. Cytologic, histologic, cytochemical, ultrastructural, and cytogenetic observations. (57715)
1976
49
SYNDROME OF ERYTHREMIA DI GUGLIELMO AFTER LIGHTNING INJURY WITH AUTOIMMUNE ANTIBODIES AND TERMINATING IN ACUTE MONOCYTIC LEUKEMIA. (14282054)
1965
50
Acute monocytic leukemia responsive to ACTH therapy. (13002763)
1952

Variations for Acute Monocytic Leukemia

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Expression for genes affiliated with Acute Monocytic Leukemia

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Expression patterns in normal tissues for genes affiliated with Acute Monocytic Leukemia

Search GEO for disease gene expression data for Acute Monocytic Leukemia.

Pathways for genes affiliated with Acute Monocytic Leukemia

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Pathways related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 50)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7EP300, NME1
29.5CSF1, MPO
39.5CSF1, CREBBP
49.5CREBBP, EP300
59.5EP300, CREBBP
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.5CREBBP, EP300
7
Show member pathways
9.5CREBBP, EP300
89.5CREBBP, EP300
9
Show member pathways
FOXA transcription factor networks37
9.5EP300, CREBBP
109.5CREBBP, EP300
119.5CREBBP, EP300
129.5CREBBP, EP300
139.5EP300, CREBBP
14
Show member pathways
p53 pathway37
9.5CREBBP, EP300
159.5CREBBP, EP300
16
Show member pathways
9.5EP300, CREBBP
17
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling60
9.5EP300, CREBBP
189.5EP300, CREBBP
199.5EP300, CREBBP
209.5EP300, CREBBP
21
Show member pathways
DNA damage Role of SUMO in p53 regulation60
9.5EP300, CREBBP
22
Show member pathways
9.5CREBBP, EP300
239.5CREBBP, EP300
249.5EP300, CREBBP
25
Show member pathways
IFN-gamma pathway37
9.5CREBBP, EP300
269.5EP300, CREBBP
279.5CREBBP, EP300
289.5EP300, CREBBP
299.5CREBBP, EP300
30
Show member pathways
9.5CREBBP, EP300
31
Show member pathways
9.5CREBBP, EP300
329.5EP300, CREBBP
339.5EP300, CREBBP
349.5CREBBP, EP300
359.5CD14, CD40
369.2EP300, THBD
379.2EP300, CREBBP, NME1
389.2EP300, CREBBP, NME1
399.1EP300, CREBBP, CD14
40
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1EP300, CREBBP, CD14
41
Show member pathways
9.1CD14, CREBBP, EP300
429.0CREBBP, EP300, MPO
439.0MPO, CD14, CD40
44
Show member pathways
8.9EP300, CREBBP, CD40
458.9CD40, CREBBP, EP300
468.9CD40, CREBBP, EP300
478.9CD40, CREBBP, EP300
48
Show member pathways
8.7CREBBP, EP300, THBD
49
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5EP300, CREBBP, CD14, CD40
50
Show member pathways
8.1CD40, CD14, CREBBP, CSF1, EP300

Compounds for genes affiliated with Acute Monocytic Leukemia

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Compounds related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate449.6CD14, MPO
2mitoxantrone44 50 1111.4MPO, CSF1, CREBBP
3etoposide44 50 61 1112.1NME1, CREBBP, CSF1, EP300
45fluorouracil449.0NME1, CREBBP, CSF1, MPO
5pentoxifylline44 1110.0CD14, MPO, THBD
6n-formylmethionyl-leucylphenylalanine449.0THBD, MPO, CSF1
7p003448.9CD40, CD14, CREBBP, CSF1
8mannose448.9CD40, CD14, CREBBP, CSF1
9rantes448.9CD40, CD14, CREBBP, CSF1
10ly294002448.9EP300, CSF1, CD14, CD40
11wortmannin448.9CD40, CD14, CSF1, EP300
12glutamine448.8CD14, NME1, CREBBP, EP300
13dmso448.7THBD, MPO, CSF1, NME1
14carboplatin44 50 1110.7MPO, CSF1, CREBBP
15doxorubicin44 50 1110.7EP300, CSF1, CREBBP, CD40
16neopterin448.7THBD, CSF1, CD14, CD40
17dbc-amp448.7CD14, CREBBP, THBD
18cisplatin44 50 61 1111.6MPO, EP300, CSF1, CREBBP, NME1
19vitamin d448.6CD14, CREBBP, EP300, THBD
20calcitriol44 61 24 1111.5THBD, EP300, CSF1, NME1, CD14
21pd 98,059448.5EP300, CSF1, CREBBP, CD14, CD40
22chloramphenicol44 2 50 1111.5THBD, MPO, CSF1, CD40
23aspartate448.4THBD, EP300, CSF1, NME1, CD14
24superoxide44 249.4CD40, CD14, CREBBP, CSF1, MPO
25phosphatidylinositol448.4EP300, CSF1, CREBBP, CD14, CD40
26lactate448.4THBD, MPO, CSF1, NME1, CD14
27actinomycin d448.3THBD, EP300, CSF1, CD40
28retinoid448.3THBD, EP300, CSF1, CREBBP, CD14
29dexamethasone44 50 28 1111.2THBD, CSF1, NME1, CD14, CD40
30arginine448.2CD14, CREBBP, CSF1, EP300, THBD
31prednisolone44 28 1110.2THBD, MPO, CSF1, CD14, CD40
32forskolin44 50 1110.1THBD, CREBBP, CD14, CD40
33histamine44 28 2410.1THBD, MPO, CSF1, CD14, CD40
34estrogen448.1NME1, CREBBP, CSF1, EP300, THBD
35atp44 289.1CD14, NME1, CREBBP, EP300, THBD
36butyrate448.0MPO, EP300, CSF1, CREBBP, CD14, CD40
37cyclophosphamide44 50 1110.0THBD, MPO, CSF1, CREBBP, CD40
38alanine447.9THBD, EP300, CSF1, CREBBP, NME1, CD14
39paraffin447.8THBD, MPO, CSF1, NME1, CD14, CD40
40glucose447.8THBD, EP300, CREBBP, CD14, CD40
41steroid447.8THBD, EP300, CREBBP, NME1, CD14, CD40
42progesterone44 28 61 24 1111.7THBD, EP300, CSF1, CREBBP, NME1, CD40
43pge2447.7MPO, EP300, CSF1, CREBBP, NME1, CD14
44tyrosine447.6THBD, EP300, CSF1, CREBBP, NME1, CD40
45nitric oxide44 24 119.6THBD, MPO, EP300, CREBBP, NME1, CD40
46cysteine447.4THBD, EP300, CSF1, CREBBP, NME1, CD14
47creatinine446.9CD40, THBD, MPO, EP300, CSF1, CREBBP
48vegf446.9THBD, MPO, EP300, CSF1, CREBBP, NME1
49retinoic acid44 247.8THBD, MPO, EP300, CSF1, CREBBP, NME1
50serine446.8THBD, MPO, EP300, CSF1, CREBBP, NME1

GO Terms for genes affiliated with Acute Monocytic Leukemia

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Cellular components related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase complexGO:0001239.5CREBBP, EP300
2extracellular spaceGO:0056157.4CD40, CD14, CSF1, MPO, THBD

Biological processes related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA bindingGO:0433889.8NME1, EP300
2response to tumor necrosis factorGO:0346129.8CD14, EP300
3N-terminal peptidyl-lysine acetylationGO:0180769.7CREBBP, EP300
4regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.6EP300, CREBBP
5cellular response to lipopolysaccharideGO:0712229.5CD40, CD14
6response to cAMPGO:0515919.2THBD, NME1
7positive regulation of type I interferon productionGO:0324819.2CREBBP, EP300
8inflammatory responseGO:0069549.1CD40, CD14, CSF1
9innate immune responseGO:0450878.9EP300, CSF1, CREBBP, CD14

Molecular functions related to Acute Monocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activityGO:0164079.6CREBBP, EP300
2RNA polymerase II activating transcription factor bindingGO:0011029.6CREBBP, EP300
3histone acetyltransferase activityGO:0044029.4CREBBP, EP300
4antigen bindingGO:0038239.4CD40, EP300
5p53 bindingGO:0020399.2CREBBP, EP300
6chromatin bindingGO:0036829.0MPO, EP300, CREBBP

Products for genes affiliated with Acute Monocytic Leukemia

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Sources for Acute Monocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet