MCID: ACT105
MIFTS: 40

Acute Mountain Sickness malady

Summaries for Acute Mountain Sickness

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63Wikipedia, 32MalaCards
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Wikipedia:63 Altitude sickness—also known as acute mountain sickness (AMS), altitude illness, hypobaropathy, \"the... more...

MalaCards: Acute Mountain Sickness, also known as high altitude pulmonary edema, is related to obesity and sarcoidosis. An important gene associated with Acute Mountain Sickness is BDKRB2 (bradykinin receptor B2), and among its related pathways are HIF-2-alpha transcription factor network and p70S6K Signaling. The compounds superoxide and norepinephrine have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and embryogenesis.

Aliases & Classifications for Acute Mountain Sickness

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42NIH Rare Diseases, 60UMLS, 48Orphanet, 26ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
high altitude pulmonary edema:
Prevalence: 1-9/1000000


Aliases & Descriptions:

acute mountain sickness 42 60
high altitude pulmonary edema 42 48
high altitude cerebral edema 42
altitude sickness 42
mountain sickness 42
altitude anoxia 42


External Ids:

ICD10 via Orphanet26 J81

Related Diseases for Acute Mountain Sickness

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Acute Mountain Sickness:



Diseases related to acute mountain sickness

Clinical Features for Acute Mountain Sickness

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Drugs & Therapeutics for Acute Mountain Sickness

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Acute Mountain Sickness

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Genetic Tests for Acute Mountain Sickness

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Anatomical Context for Acute Mountain Sickness

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Animal Models for Acute Mountain Sickness or affiliated genes

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36MGI
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Publications for Acute Mountain Sickness

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Genetic Variations for Acute Mountain Sickness

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Expression for genes affiliated with Acute Mountain Sickness

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Mountain Sickness

Search GEO for disease gene expression data for Acute Mountain Sickness.

Pathways for genes affiliated with Acute Mountain Sickness

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 29KEGG, 49PharmGKB, 4Cell Signaling Technology, 12EMD Millipore, 55SinoBiological
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Pathways related to Acute Mountain Sickness according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FLT1, VHL
2
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9.9ACE, AGTR1
39.9HIF1A, VHL
4
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9.5VEGFA, FLT1
59.4BDKRB2, AGTR1, NOS3, ADRB2
6
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9.4ACE, NOS3, AGTR1, BDKRB2
7
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9.2BDKRB2, CCK, EDN1, AGTR1
8
CFTR folding and maturation (norm and CF)
9.2NOS3, HSPA1A, HSPA1B
9
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9.2HIF1A, VEGFA, VHL
109.2NOS3, HIF1A, FLT1, VHL
11
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9.2HSPA1B, HSPA1A, FLT1
12
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.0EDN1, VEGFA, HIF1A
139.0HIF1A, VEGFA, EDN1
14
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9.0BDKRB2, CCK, EDN1, AGTR1, ADRB2
15
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9.0PIK3C2A, FLT1, VEGFA
168.9ADRB2, FLT1, HSPA1A, HSPA1B
17
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8.9CCK, FLT1, VEGFA, NOS3
18
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8.9VHL, VEGFA, HIF1A, NOS3
198.8FLT1, VEGFA, HIF1A, NOS3
20
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8.6VHL, FLT1, VEGFA, HIF1A, NOS3
218.2HSPA1B, HSPA1A, VHL, EDN1, HIF1A, NOS3
22
Development Endothelin-1/EDNRA signaling
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8.2HSPA1B, HSPA1A, EDN1, VEGFA, NOS3
23
Hide members
7.7BDKRB2, CCK, EDN1, FLT1, AGTR1, VEGFA
247.3ENO2, VHL, EDN1, FLT1, VEGFA, HIF1A

Compounds for genes affiliated with Acute Mountain Sickness

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Acute Mountain Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1superoxide44 2411.3AGTR1, NOS3
2norepinephrine44 11 2412.0CCK, MB, HSPA1A
3captopril44 28 49 59 1114.0EDN1, BDKRB2
4lacidipine449.7EDN1, AGTR1, ACE
5cilazapril44 1110.6AGTR1, ACE, EDN1
6nebivolol44 1110.6ADRB2, NOS3, EDN1, ACE
7bradykinin59 28 2411.6BDKRB2, AGTR1, ACE
8trandolapril44 1110.5AGTR1, ACE, EDN1
9pge2449.5BDKRB2, MB, VEGFA, ADRB2
10potassium44 11 2411.5AGTR1, PIK3C2A, ACE, VHL
11diltiazem44 28 1111.5CCK, EDN1, AGTR1, ACE
12isoproterenol44 1110.5BDKRB2, PIK3C2A, AGTR1
13lisinopril44 11 2411.4BDKRB2, ACE, VEGFA, AGTR1
14isosorbide dinitrate44 49 1111.4NOS3, EDN1, ACE
15perindopril44 49 1111.3AGTR1, NOS3, ACE, VEGFA
168-isoprostane449.3AGTR1, HSPA1A, EDN1, NOS3
17sunitinib44 49 1111.2FLT1, HIF1A, VHL, VEGFA
18glucose449.1CCK, PIK3C2A, FLT1, HIF1A, AGTR1
19halothane44 28 1111.1MB, HIF1A, ADRB2, HSPA1A, PIK3C2A
20radicicol44 59 1111.0VEGFA, HSPA1A, HIF1A, NOS3
21l-nmma449.0BDKRB2, CCK, EDN1, AGTR1, HIF1A, NOS3
22sodium44 2410.0BDKRB2, EDN1, PIK3C2A, AGTR1, ACE
23oxygen44 249.9VHL, MB, HSPA1A, PIK3C2A, FLT1, ADRB2
24ang ii448.9ACE, EDN1, AGTR1, VEGFA, NOS3
25geldanamycin44 49 59 1111.9VHL, HSPA1A, HIF1A, NOS3, VEGFA
26thapsigargin44 599.8HIF1A, HSPA1A, BDKRB2, EDN1, CCK, NOS3
27candesartan44 28 1110.8ACE, NOS3, HIF1A, VEGFA, AGTR1, BDKRB2
28carvedilol44 49 28 1111.7EDN1, ADRB2, ACE, AGTR1, VEGFA, NOS3
29nitroglycerin44 119.6HIF1A, AGTR1, ACE, NOS3, EDN1, PIK3C2A
30epinephrine44 11 2410.6HSPA1A, EDN1, PIK3C2A, AGTR1, ADRB2, MB
31glycerol44 11 2410.6MB, ADRB2, NOS3, CCK, PIK3C2A
32phosphoinositide448.4PIK3C2A, EDN1, AGTR1, HIF1A, ADRB2, BDKRB2
33creatinine448.3MB, AGTR1, ADRB2, FLT1, PIK3C2A, BDKRB2
34sodium nitroprusside448.3NOS3, HIF1A, AGTR1, PIK3C2A, EDN1, MB
35doxorubicin44 49 1110.3HIF1A, NOS3, PIK3C2A, FLT1, VEGFA, MB
36genistein44 28 59 2 11 2413.2BDKRB2, EDN1, NOS3, FLT1, HIF1A, VEGFA
37actinomycin d448.2AGTR1, VEGFA, HIF1A, VHL, NOS3, EDN1
38dexamethasone44 49 28 1111.1ENO2, HIF1A, VEGFA, CCK, BDKRB2, HSPA1A
39pd 98,059448.1HSPA1A, NOS3, ENO2, EDN1, BDKRB2, HIF1A
40sb 20358044 599.1AGTR1, HSPA1A, EDN1, VEGFA, FLT1, HIF1A
41phosphatidylinositol448.1AGTR1, NOS3, FLT1, PIK3C2A, EDN1, BDKRB2
42prostacyclin448.0AGTR1, EDN1, VEGFA, ACE, NOS3, PIK3C2A
43glutamate447.9BDKRB2, CCK, PIK3C2A, AGTR1, NOS3, ADRB2
44arginine447.6NOS3, HIF1A, ADRB2, PIK3C2A, BDKRB2, CCK
45acetylcholine44 49 28 11 2411.5NOS3, ADRB2, MB, ENO2, ACE, AGTR1
46cisplatin44 49 59 1110.3MB, AGTR1, VEGFA, ENO2, FLT1, PIK3C2A
47nitric oxide44 11 248.9HSPA1A, BDKRB2, VHL, EDN1, ENO2, ACE
48calcium44 49 11 249.6PIK3C2A, CCK, ACE, VHL, BDKRB2, HSPA1A
49tyrosine446.5AGTR1, HSPA1A, ADRB2, ENO2, HIF1A, BDKRB2
50vegf446.3BDKRB2, NOS3, HIF1A, VEGFA, AGTR1, FLT1

GO Terms for genes affiliated with Acute Mountain Sickness

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16Gene Ontology
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Cellular components related to Acute Mountain Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:0057689.3ADRB2, ACE, FLT1, BDKRB2

Biological processes related to Acute Mountain Sickness according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.1ACE, AGTR1
2regulation of sodium ion transportGO:00202810.0ADRB2, NOS3
3regulation of vasodilationGO:04231210.0ADRB2, ACE, AGTR1
4regulation of systemic arterial blood pressure by endothelinGO:00310010.0NOS3, EDN1
5positive regulation of chemokine-mediated signaling pathwayGO:07010110.0HIF1A, EDN1
6positive regulation of receptor biosynthetic processGO:0108709.9HIF1A, EDN1
7arachidonic acid secretionGO:0504829.8BDKRB2, ACE
8vasoconstrictionGO:0423109.8EDN1, BDKRB2
9positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.8HIF1A, VEGFA
10elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.7EDN1, AGTR1
11elevation of cytosolic calcium ion concentrationGO:0072049.7BDKRB2, EDN1, AGTR1
12regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.6VHL, VEGFA, HIF1A
13dopaminergic neuron differentiationGO:0715429.5HIF1A, VEGFA
14regulation of vasoconstrictionGO:0192299.5ACE, AGTR1, EDN1, BDKRB2
15positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.5FLT1, VEGFA, HIF1A
16cellular response to hypoxiaGO:0714569.4VHL, VEGFA, HIF1A
17kidney developmentGO:0018229.4ACE, VEGFA, AGTR1
18patterning of blood vesselsGO:0015699.4VEGFA, FLT1, EDN1
19positive regulation of MAP kinase activityGO:0434069.3EDN1, FLT1, VEGFA
20positive regulation of angiogenesisGO:0457669.2NOS3, HIF1A, VEGFA, FLT1
21response to hypoxiaGO:0016669.1MB, EDN1, VEGFA, HIF1A
22positive regulation of cell migrationGO:0303358.8VEGFA, FLT1, EDN1

Molecular functions related to Acute Mountain Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.8ACE, AGTR1
2protein heterodimerization activityGO:0469829.0HIF1A, VEGFA, AGTR1, BDKRB2
3protein bindingGO:0055156.0HSPA1B, BDKRB2, VHL, CCK, EDN1, FLT1

Products for genes affiliated with Acute Mountain Sickness

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  • Antibodies
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Sources for Acute Mountain Sickness

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet