MCID: ACT105
MIFTS: 50

Acute Mountain Sickness malady

Summaries for Acute Mountain Sickness

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64Wikipedia, 33MalaCards
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Wikipedia:64 Altitude sickness—also known as acute mountain sickness (AMS), altitude illness, hypobaropathy, \"the... more...

MalaCards: Acute Mountain Sickness, also known as high altitude pulmonary edema, is related to bronchopulmonary dysplasia and primary pulmonary hypertension. An important gene associated with Acute Mountain Sickness is BDKRB2 (bradykinin receptor B2), and among its related pathways are HIF-2-alpha transcription factor network and p70S6K Signaling. The compounds superoxide and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skeletal muscle, and related mouse phenotypes are endocrine/exocrine gland and embryogenesis.

Aliases & Classifications for Acute Mountain Sickness

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

49
high altitude pulmonary edema:
Prevalence: 1-9/1000000


Aliases & Descriptions:

acute mountain sickness 43 61
high altitude pulmonary edema 43 49
high altitude cerebral edema 43
altitude sickness 43
mountain sickness 43
altitude anoxia 43


External Ids:

ICD10 via Orphanet26 J81

Related Diseases for Acute Mountain Sickness

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Acute Mountain Sickness:



Diseases related to acute mountain sickness

Clinical Features for Acute Mountain Sickness

Drugs & Therapeutics for Acute Mountain Sickness

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Mountain Sickness

Drug clinical trials:

Search ClinicalTrials for Acute Mountain Sickness

Search NIH Clinical Center for Acute Mountain Sickness

Search CenterWatch for Acute Mountain Sickness

Genetic Tests for Acute Mountain Sickness

Anatomical Context for Acute Mountain Sickness

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Mountain Sickness:

33
Brain, Heart, Skeletal muscle, Lung, Endothelial, Pituitary

Animal Models for Acute Mountain Sickness or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Mountain Sickness:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2BDKRB2, CCK
2MP:00053809.6EDN1, MB, VHL
3MP:00053899.4VHL, FLT1, VEGFA
4MP:00053909.4VEGFA, NOS3, ADRB2
5MP:00053698.9VHL, MB, FLT1, HIF1A, NOS3, ADRB2
6MP:00053758.8BDKRB2, PIK3C2A, NOS3, ACE, ADRB2
7MP:00036318.6ENO2, EDN1, CCK, HSPA1B
8MP:00053768.4ADRB2, BDKRB2, CCK, MB, PIK3C2A, AGTR1
9MP:00053678.4BDKRB2, VHL, EDN1, PIK3C2A, AGTR1, HIF1A
10MP:00053818.3VHL, EDN1, VEGFA, HIF1A, NOS3, BDKRB2
11MP:00028737.9BDKRB2, VHL, EDN1, FLT1, VEGFA, HIF1A
12MP:00053977.3BDKRB2, VHL, MB, PIK3C2A, FLT1, VEGFA
13MP:00053866.9BDKRB2, FLT1, VEGFA, HIF1A, NOS3, ACE
14MP:00053876.7HSPA1B, BDKRB2, VHL, PIK3C2A, FLT1, AGTR1
15MP:00053786.3PIK3C2A, MB, VHL, HSPA1A, HSPA1B, FLT1
16MP:00107686.3EDN1, MB, VHL, BDKRB2, HSPA1B, PIK3C2A
17MP:00053856.2HSPA1B, HSPA1A, BDKRB2, VHL, MB, EDN1
18MP:00053846.1HSPA1B, HSPA1A, BDKRB2, VHL, MB, FLT1

Publications for Acute Mountain Sickness

Sources:
51PubMed
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Articles related to Acute Mountain Sickness:

(show top 50)    (show all 471)
idTitleAuthorsYear
1
AltitudeOmics: Cerebral autoregulation during ascent, acclimatization, and re-exposure to high altitude and its relation with acute mountain sickness. (24371013)
2013
2
Is poor sleep quality at high altitude separate from acute mountain sickness? Factor structure and internal consistency of the lake louise score questionnaire. (24377339)
2013
3
Evaluation of the Balance Error Scoring System (BESS) in the diagnosis of acute mountain sickness at 4380a88m. (22724611)
2012
4
Who are more at risk for acute mountain sickness: a prospective study in Qinghai-Tibet railroad construction workers on Mt. Tanggula. (22613641)
2012
5
Con: Headache should not be a required symptom for the diagnosis of acute mountain sickness. (21452961)
2011
6
Endocrine aspects of high altitude acclimatization and acute mountain sickness. (21465908)
2011
7
End-tidal partial pressure of carbon dioxide and acute mountain sickness in the first 24 hours upon ascent to Cusco Peru (3326 meters). (20591371)
2010
8
Comparison of a visual analogue scale and Lake Louise symptom scores for acute mountain sickness. (20367491)
2010
9
Genotype at the missense G894T polymorphism (Glu298Asp) in the NOS3 gene is associated with susceptibility to acute mountain sickness. (19775216)
2009
10
Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness? (19726713)
2009
11
Acute mountain sickness in children and their parents after rapid ascent to 3500 m (Putre, Chile). (19099320)
2008
12
Direct measurement of intracranial pressure at high altitude and correlation of ventricular size with acute mountain sickness: Brian Cummins' results from the 1985 Kishtwar expedition. (19005388)
2008
13
Glomerular filtration rate estimates decrease during high altitude expedition but increase with Lake Louise acute mountain sickness scores. (17970827)
2008
14
Low-dose acetylsalicylic Acid analog and acetazolamide for prevention of acute mountain sickness. (19115924)
2008
15
Transient myoclonic jerks and restless legs during periodic tachypnea in acute mountain sickness. (17995536)
2007
16
Comparing questionnaires for the assessment of acute mountain sickness. (17824818)
2007
17
No association between variants in the ACE and angiotensin II receptor 1 genes and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 m. (17173513)
2006
18
Acute mountain sickness and ascent rates in trekkers above 2500 m in the Nepali Himalaya. (16856361)
2006
19
Early fluid retention and severe acute mountain sickness. (15501929)
2005
20
The sharpened Romberg test for assessing ataxia in mild acute mountain sickness. (15974254)
2005
21
Ginkgo biloba and acetazolamide for acute mountain sickness: exclusion of high risk, low status groups perpetuates discrimination and inequalities. (15258082)
2004
22
Acute mountain sickness: controversies and advances. (15265333)
2004
23
Cysteinyl leukotriene blockade does not prevent acute mountain sickness. (15152893)
2004
24
Summaries for patients. Obesity and acute mountain sickness. (12965998)
2003
25
Does theophylline really improve acute mountain sickness? (11405540)
2001
26
Acute mountain sickness at the South pole? (11809098)
2001
27
A potential role for free radical-mediated skeletal muscle soreness in the pathophysiology of acute mountain sickness. (11396556)
2001
28
Pharmacological prevention of acute mountain sickness. Same ascent rates must be used to assess effectiveness of different doses of acetazolamide. (11141168)
2001
29
Acute mountain sickness: the "poison of the pass" (10854392)
2000
30
Exercise exacerbates acute mountain sickness at simulated high altitude. (10658026)
2000
31
Prediction of acute mountain sickness. (7580641)
1995
32
The effect of altitude pre-acclimatization on acute mountain sickness during reexposure. (8526832)
1995
33
Acute mountain sickness in a general tourist population at moderate altitudes. (8452324)
1993
34
Acute mountain sickness susceptibility, fitness and hypoxic ventilatory response. (1783072)
1991
35
Cognitive changes at high altitude in healthy climbers and in climbers developing acute mountain sickness. (2031628)
1991
36
Prevalence of acute mountain sickness in the Swiss Alps. (2282425)
1990
37
Incidence of acute mountain sickness at intermediate altitudes. (2724500)
1989
38
Incidence of acute mountain sickness at intermediate altitude. (2911169)
1989
39
Acute mountain sickness. (2716800)
1989
40
Dexamethasone in the treatment of acute mountain sickness. (2687688)
1989
41
Acute mountain sickness at 4500 m is not altered by repeated eight-hour exposures to 3200-3550 m normobaric hypoxic equivalent. (3142454)
1988
42
Hypoxic ventilatory response and acute mountain sickness. (3224691)
1988
43
Acetazolamide in prevention of acute mountain sickness. (3533677)
1986
44
The clinical assessment of acute mountain sickness. (3975347)
1985
45
Cerebral etiology of acute mountain sickness: a case report. (4000444)
1985
46
Spironolactone and acute mountain sickness. (600194)
1977
47
Use of spironolactone in the prevention of acute mountain sickness on Kilimanjaro. (612430)
1977
48
Acute mountain sickness. (64851)
1977
49
Spironolactone and acute mountain sickness. (979834)
1976
50
Acute mountain sickness. (5782719)
1969

Genetic Variations for Acute Mountain Sickness

Expression for genes affiliated with Acute Mountain Sickness

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Mountain Sickness

Search GEO for disease gene expression data for Acute Mountain Sickness.

Pathways for genes affiliated with Acute Mountain Sickness

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 30KEGG, 50PharmGKB, 4Cell Signaling Technology, 12EMD Millipore, 56SinoBiological
See all sources

Pathways related to Acute Mountain Sickness according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FLT1, VHL
2
Hide members
9.9ACE, AGTR1
39.9HIF1A, VHL
4
Hide members
9.5VEGFA, FLT1
59.4BDKRB2, AGTR1, NOS3, ADRB2
6
Hide members
9.4ACE, NOS3, AGTR1, BDKRB2
7
Hide members
9.2BDKRB2, CCK, EDN1, AGTR1
8
CFTR folding and maturation (norm and CF)
9.2NOS3, HSPA1A, HSPA1B
9
Hide members
9.2HIF1A, VEGFA, VHL
109.2NOS3, HIF1A, FLT1, VHL
11
Hide members
9.2HSPA1B, HSPA1A, FLT1
12
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.0EDN1, VEGFA, HIF1A
139.0HIF1A, VEGFA, EDN1
14
Hide members
9.0BDKRB2, CCK, EDN1, AGTR1, ADRB2
15
Hide members
9.0PIK3C2A, FLT1, VEGFA
168.9ADRB2, FLT1, HSPA1A, HSPA1B
17
Hide members
8.9CCK, FLT1, VEGFA, NOS3
18
Hide members
8.9VHL, VEGFA, HIF1A, NOS3
198.8FLT1, VEGFA, HIF1A, NOS3
20
Hide members
8.6VHL, FLT1, VEGFA, HIF1A, NOS3
218.2HSPA1B, HSPA1A, VHL, EDN1, HIF1A, NOS3
22
Development Endothelin-1/EDNRA signaling
Hide members
8.2HSPA1B, HSPA1A, EDN1, VEGFA, NOS3
23
Hide members
7.7BDKRB2, CCK, EDN1, FLT1, AGTR1, VEGFA
247.3ENO2, VHL, EDN1, FLT1, VEGFA, HIF1A

Compounds for genes affiliated with Acute Mountain Sickness

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Acute Mountain Sickness according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1superoxide45 2411.3AGTR1, NOS3
2norepinephrine45 11 2412.0CCK, MB, HSPA1A
3captopril45 29 50 60 1114.0EDN1, BDKRB2
4lacidipine459.7EDN1, AGTR1, ACE
5cilazapril45 1110.6AGTR1, ACE, EDN1
6nebivolol45 1110.6ADRB2, NOS3, EDN1, ACE
7bradykinin60 29 2411.6BDKRB2, AGTR1, ACE
8trandolapril45 1110.5AGTR1, ACE, EDN1
9pge2459.5BDKRB2, MB, VEGFA, ADRB2
10potassium45 11 2411.5AGTR1, PIK3C2A, ACE, VHL
11diltiazem45 29 1111.5CCK, EDN1, AGTR1, ACE
12isoproterenol45 1110.5BDKRB2, PIK3C2A, AGTR1
13lisinopril45 11 2411.4BDKRB2, ACE, VEGFA, AGTR1
14isosorbide dinitrate45 50 1111.4NOS3, EDN1, ACE
15perindopril45 50 1111.3AGTR1, NOS3, ACE, VEGFA
168-isoprostane459.3AGTR1, HSPA1A, EDN1, NOS3
17sunitinib45 50 1111.2FLT1, HIF1A, VHL, VEGFA
18glucose459.1CCK, PIK3C2A, FLT1, HIF1A, AGTR1
19halothane45 29 1111.1MB, HIF1A, ADRB2, HSPA1A, PIK3C2A
20radicicol45 60 1111.0VEGFA, HSPA1A, HIF1A, NOS3
21l-nmma459.0BDKRB2, CCK, EDN1, AGTR1, HIF1A, NOS3
22sodium45 2410.0BDKRB2, EDN1, PIK3C2A, AGTR1, ACE
23oxygen45 249.9VHL, MB, HSPA1A, PIK3C2A, FLT1, ADRB2
24ang ii458.9ACE, EDN1, AGTR1, VEGFA, NOS3
25geldanamycin45 50 60 1111.9VHL, HSPA1A, HIF1A, NOS3, VEGFA
26thapsigargin45 609.8HIF1A, HSPA1A, BDKRB2, EDN1, CCK, NOS3
27candesartan45 29 1110.8ACE, NOS3, HIF1A, VEGFA, AGTR1, BDKRB2
28carvedilol45 50 29 1111.7EDN1, ADRB2, ACE, AGTR1, VEGFA, NOS3
29nitroglycerin45 119.6HIF1A, AGTR1, ACE, NOS3, EDN1, PIK3C2A
30epinephrine45 11 2410.6HSPA1A, EDN1, PIK3C2A, AGTR1, ADRB2, MB
31glycerol45 11 2410.6MB, ADRB2, NOS3, CCK, PIK3C2A
32phosphoinositide458.4PIK3C2A, EDN1, AGTR1, HIF1A, ADRB2, BDKRB2
33creatinine458.3MB, AGTR1, ADRB2, FLT1, PIK3C2A, BDKRB2
34sodium nitroprusside458.3NOS3, HIF1A, AGTR1, PIK3C2A, EDN1, MB
35doxorubicin45 50 1110.3HIF1A, NOS3, PIK3C2A, FLT1, VEGFA, MB
36genistein45 29 60 2 11 2413.2BDKRB2, EDN1, NOS3, FLT1, HIF1A, VEGFA
37actinomycin d458.2AGTR1, VEGFA, HIF1A, VHL, NOS3, EDN1
38dexamethasone45 50 29 1111.1ENO2, HIF1A, VEGFA, CCK, BDKRB2, HSPA1A
39pd 98,059458.1HSPA1A, NOS3, ENO2, EDN1, BDKRB2, HIF1A
40sb 20358045 609.1AGTR1, HSPA1A, EDN1, VEGFA, FLT1, HIF1A
41phosphatidylinositol458.1AGTR1, NOS3, FLT1, PIK3C2A, EDN1, BDKRB2
42prostacyclin458.0AGTR1, EDN1, VEGFA, ACE, NOS3, PIK3C2A
43glutamate457.9BDKRB2, CCK, PIK3C2A, AGTR1, NOS3, ADRB2
44arginine457.6NOS3, HIF1A, ADRB2, PIK3C2A, BDKRB2, CCK
45acetylcholine45 50 29 11 2411.5NOS3, ADRB2, MB, ENO2, ACE, AGTR1
46cisplatin45 50 60 1110.3MB, AGTR1, VEGFA, ENO2, FLT1, PIK3C2A
47nitric oxide45 11 248.9HSPA1A, BDKRB2, VHL, EDN1, ENO2, ACE
48calcium45 50 11 249.6PIK3C2A, CCK, ACE, VHL, BDKRB2, HSPA1A
49tyrosine456.5AGTR1, HSPA1A, ADRB2, ENO2, HIF1A, BDKRB2
50vegf456.3BDKRB2, NOS3, HIF1A, VEGFA, AGTR1, FLT1

GO Terms for genes affiliated with Acute Mountain Sickness

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Mountain Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosomeGO:0057689.3ADRB2, ACE, FLT1, BDKRB2

Biological processes related to Acute Mountain Sickness according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.1ACE, AGTR1
2regulation of sodium ion transportGO:00202810.0ADRB2, NOS3
3regulation of vasodilationGO:04231210.0ADRB2, ACE, AGTR1
4regulation of systemic arterial blood pressure by endothelinGO:00310010.0NOS3, EDN1
5positive regulation of chemokine-mediated signaling pathwayGO:07010110.0HIF1A, EDN1
6positive regulation of receptor biosynthetic processGO:0108709.9HIF1A, EDN1
7arachidonic acid secretionGO:0504829.8BDKRB2, ACE
8vasoconstrictionGO:0423109.8EDN1, BDKRB2
9positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.8HIF1A, VEGFA
10elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.7EDN1, AGTR1
11elevation of cytosolic calcium ion concentrationGO:0072049.7BDKRB2, EDN1, AGTR1
12regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.6VHL, VEGFA, HIF1A
13dopaminergic neuron differentiationGO:0715429.5HIF1A, VEGFA
14regulation of vasoconstrictionGO:0192299.5ACE, AGTR1, EDN1, BDKRB2
15positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.5FLT1, VEGFA, HIF1A
16cellular response to hypoxiaGO:0714569.4VHL, VEGFA, HIF1A
17kidney developmentGO:0018229.4ACE, VEGFA, AGTR1
18patterning of blood vesselsGO:0015699.4VEGFA, FLT1, EDN1
19positive regulation of MAP kinase activityGO:0434069.3EDN1, FLT1, VEGFA
20positive regulation of angiogenesisGO:0457669.2NOS3, HIF1A, VEGFA, FLT1
21response to hypoxiaGO:0016669.1MB, EDN1, VEGFA, HIF1A
22positive regulation of cell migrationGO:0303358.8VEGFA, FLT1, EDN1

Molecular functions related to Acute Mountain Sickness according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.8ACE, AGTR1
2protein heterodimerization activityGO:0469829.0HIF1A, VEGFA, AGTR1, BDKRB2
3protein bindingGO:0055156.0HSPA1B, BDKRB2, VHL, CCK, EDN1, FLT1

Products for genes affiliated with Acute Mountain Sickness

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Sources for Acute Mountain Sickness

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet