MCID: ACT019
MIFTS: 92

Acute Myeloid Leukemia malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories

Summaries for Acute Myeloid Leukemia

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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute myeloid leukemia (aml), there are too many of a specific type of white blood cell called a myeloblast. aml is the most common type of acute leukemia in adults. this type of cancer usually gets worse quickly if it is not treated. possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. symptoms of aml include: fever shortness of breath easy bruising or bleeding bleeding under the skin weakness or feeling tired weight loss or loss of appetite tests that examine the blood and bone marrow diagnose aml. treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards based summary: Acute Myeloid Leukemia, also known as aml - acute myeloid leukemia, is related to myeloid leukemia and leukemia, and has symptoms including autosomal dominant inheritanceand acute myeloid leukemia. An important gene associated with Acute Myeloid Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs cyclophosphamide and etoposide and the compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are cellular and mortality/aging.

Disease Ontology:9 A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.

Wikipedia:64 Acute myeloid leukemia (AML), also known as acute myelogenous leukemia or acute nonlymphocytic leukemia... more...

Descriptions from OMIM:46 601626,602439

Aliases & Classifications for Acute Myeloid Leukemia

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Acute Myeloid Leukemia, Aliases & Descriptions:

Name: Acute Myeloid Leukemia 31 9 11 33
Aml - Acute Myeloid Leukemia 9 23
Leukemia, Acute Myeloblastic 10 46
Leukemia, Myelocytic, Acute 9 61
 
Aml - Acute Myeloid Leukaemia 61
Acute Myeloblastic Leukemia 9
Acute Myelocytic Leukemia 42
Leukemia, Acute Myeloid 46


Classifications:



External Ids:

Disease Ontology9 DOID:9119
MeSH34 D015470
ICD9CM28 205.0

Related Diseases for Acute Myeloid Leukemia

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Diseases in the Acute Myeloid Leukemia family:

Chronic Myeloid Leukemia Subacute Myeloid Leukemia
Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
'acute Myeloid Leukemia with T(9;11)(p22;q23)' 'acute Myeloid Leukemia with T(6;9)(p23;q34)'

Diseases related to Acute Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 335)
idRelated DiseaseScoreTop Affiliating Genes
1myeloid leukemia33.7RUNX1, PICALM, FLT3, JAK2, ETV6, KIT
2leukemia33.1FLT3, JAK2, ETV6, CEBPA, KIT, KRAS
3myelodysplastic syndromes32.5SETBP1, GATA2
4myeloid sarcoma32.3KIT, FLT3
5acute promyelocytic leukemia32.3RUNX1, FLT3, GATA2, NPM1
6refractory anemia32.1RUNX1, FLT3, JAK2, KIT
7sarcoma31.9RUNX1, TERT, JAK2, ETV6, KIT, KRAS
8myelofibrosis31.9KIT, JAK2
9systemic mastocytosis31.9KIT, JAK2
10acute lymphoblastic leukemia31.9RUNX1, PICALM, FLT3, JAK2, ETV6, KIT
11mastocytosis31.9CHIC2, KIT
12acute leukemia31.8RUNX1, TERT, FLT3, JAK2, ETV6, CEBPA
13down syndrome31.7RUNX1, FLT3, JAK2, ETV6, GATA2
14polycythemia vera31.6FLT3, JAK2, KIT
15juvenile myelomonocytic leukemia31.6KRAS, FLT3, RUNX1
16eosinophilia31.6JAK2, CHIC2, ETV6
17aplastic anemia31.5GATA2, FLT3, TERT
18chronic myeloid leukemia31.4RUNX1, FLT3, JAK2, ETV6, KIT, KRAS
19breast cancer31.3RUNX1, TERT, FLT3, JAK2, ETV6, KIT
20acute myeloid leukemia, adult31.2SETBP1, JAK2
21acute myelomonocytic leukemia31.1RUNX1, ETV6
22hematologic cancer31.1RUNX1, PICALM, FLT3, JAK2, ETV6, KIT
23precursor t-cell acute lymphoblastic leukemia31.0RUNX1, PICALM, NUP214, FLT3, JAK2, ETV6
24melanoma31.0TERT, FLT3, JAK2, KIT, KRAS
25b-cell lymphomas31.0NPM1, JAK2, FLT3
26non-hodgkin lymphoma30.9FLT3, JAK2, ETV6, NPM1
27cytogenetically normal acute myeloid leukemia11.1
28core binding factor acute myeloid leukemia11.0
29wilms tumor10.8
30hematopoietic stem cell transplantation10.8
31endotheliitis10.8
32neutropenia10.8
33lymphoblastic leukemia10.8
34chronic myelomonocytic leukemia10.7
35familial acute myeloid leukemia with mutated cebpa10.7
36acute myeloid leukemia with multilineage dysplasia10.7
37acute myeloblastic leukemia without maturation10.7
38diphtheria10.6
39aspergillosis10.6
40tetraploidy10.6
41diabetes insipidus10.6
42mn110.6
43bone marrow cancer10.6JAK2, FLT3
44graft versus host disease10.6
45mediastinitis10.6
46refractory anemia with excess blasts10.6
47severe congenital neutropenia10.6
48invasive aspergillosis10.6
49essential thrombocythemia10.6
50malignant mixed mullerian tumor10.6KRAS, KIT

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia:



Diseases related to acute myeloid leukemia

Symptoms for Acute Myeloid Leukemia

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Symptoms by clinical synopsis from OMIM:

601626

Clinical features from OMIM:

601626,602439

HPO human phenotypes related to Acute Myeloid Leukemia:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 acute myeloid leukemia HP:0004808

Drugs & Therapeutics for Acute Myeloid Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia

Search NIH Clinical Center for Acute Myeloid Leukemia

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Myeloid Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Myeloid Leukemia

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Genetic tests related to Acute Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Aml - Acute Myeloid Leukemia23

Anatomical Context for Acute Myeloid Leukemia

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MalaCards organs/tissues related to Acute Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, Testes, T cells, Skin, Monocytes, Endothelial, Breast, Nk cells, Lung, B cells, Testis, Neutrophil, Brain, Kidney, Liver, Thyroid, Eye, Spleen, Thymus, Smooth muscle, Small intestine, Colon, Pancreas, Tonsil, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Myeloid Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowCommon Myeloid Progenitor Cells Potential therapeutic candidate, affected by disease
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate

Animal Models for Acute Myeloid Leukemia or affiliated genes

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Publications for Acute Myeloid Leukemia

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Articles related to Acute Myeloid Leukemia:

(show top 50)    (show all 2970)
idTitleAuthorsYear
1
Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. (24413389)
2014
2
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
3
Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. (24120526)
2014
4
Implication of higher BAALC expression in combination with other gene mutations in adult cytogenetically normal acute myeloid leukemia. (23647058)
2014
5
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. (24035334)
2013
6
Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting. (23912609)
2013
7
Mobilization of CD34(+)CD38(-) hematopoietic stem cells after priming in acute myeloid leukemia. (24179607)
2013
8
Prognostic implication of BAALC gene expression in adult acute myeloid leukemia. (23865362)
2013
9
CAR T cells for acute myeloid leukemia: the LeY of the land. (24201214)
2013
10
Interferon I+ may be back on track to treat acute myeloid leukemia. (23734314)
2013
11
Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia. (23728608)
2013
12
FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013? (24319184)
2013
13
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
14
Receptor activator for NF-I_B ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance. (23241893)
2013
15
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting. (22929312)
2012
16
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease. (21692072)
2012
17
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-I_B and underlies its chemo-resistance. (23077289)
2012
18
High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group. (22915059)
2012
19
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. (22490330)
2012
20
Expression of HtrA2 and WT1 genes in acute myeloid leukemia]. (22391154)
2012
21
DNMT3A mutations are rare in childhood acute myeloid leukemia. (21685466)
2011
22
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. (21951951)
2011
23
Relapsing acute myeloid leukemia presenting as hypopyon uveitis. (21836350)
2011
24
A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. (21156465)
2010
25
Analysis of CEBPA mutation in acute myeloid leukemia]. (20723288)
2010
26
Peripheral blasts on day 21 of induction chemotherapy in a patient with core binding factor acute myeloid leukemia: more than meets the eye. (20709669)
2010
27
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. (19637342)
2009
28
CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy. (19092854)
2009
29
Prognostic implication of N-RAS gene mutations in Egyptian adult acute myeloid leukemia. (20726318)
2009
30
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
31
Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. (18768433)
2008
32
Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells. (18616510)
2008
33
Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells. (18268283)
2008
34
A MLL-KIAA0284 fusion gene in a patient with secondary acute myeloid leukemia and t(11;14)(q23;q32). (18640063)
2008
35
Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia. (18497996)
2008
36
Analysis of NPM1 gene mutations in acute myeloid leukemia]. (17877154)
2007
37
Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia. (17822317)
2007
38
Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (15840695)
2005
39
P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. (15661399)
2005
40
Acute myeloid leukemia associated with necrotizing temporal arteritis. (12672210)
2003
41
Efficacy and toxicity of low-dose melphalan in myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia. (12937849)
2003
42
Concomitant Mycobacterium tuberculosis and Aspergillus niger infection in a patient with acute myeloid leukemia. (14504439)
2003
43
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. (12006512)
2002
44
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML. (11986951)
2002
45
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. (12145683)
2002
46
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. (11830484)
2002
47
Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. (11587212)
2001
48
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. (11568008)
2001
49
p91 STAT1 activation in interleukin-3-stimulated primary acute myeloid leukemia cells. (8806691)
1996
50
Rearrangements and fusion gene of AML1 and MTG8 in acute myeloid leukemia M2b]. (7553157)
1995

Variations for Acute Myeloid Leukemia

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UniProtKB/Swiss-Prot genetic disease variations for Acute Myeloid Leukemia:

63
id Symbol AA change Variation ID SNP ID
1JAK2p.Lys607AsnVAR_032696
2JAK2p.Val617PheVAR_032697
3SETBP1p.Gly870SerVAR_063809
4SETBP1p.Ser854AlaVAR_069848
5SETBP1p.Gly870ArgVAR_069854
6SETBP1p.Ile871SerVAR_069856

Clinvar genetic disease variations for Acute Myeloid Leukemia:

7 (show all 31)
id Gene Name Type Significance SNP ID Assembly Location
1KRASKRAS, 3-BP INS, GLY11INSinsertionPathogenic
2KITNM_000222.2(KIT): c.2446G> T (p.Asp816Tyr)single nucleotide variantPathogenicrs121913506GRCh37Chr 4, 55599320: 55599320
3NPM1NM_002520.6(NPM1): c.860_863dupTCTG (p.Trp288Cysfs)duplicationPathogenicGRCh38Chr 5, 171410540: 171410543
4NPM1NM_002520.6(NPM1): c.863_864insCATG (p.Trp288Cysfs)insertionPathogenicGRCh38Chr 5, 171410543: 171410544
5NPM1NM_002520.6(NPM1): c.863_864insCGTG (p.Trp288Cysfs)insertionPathogenicGRCh38Chr 5, 171410543: 171410544
6NPM1NM_002520.6(NPM1): c.863_864insCCTG (p.Trp288Cysfs)insertionPathogenicGRCh38Chr 5, 171410543: 171410544
7JAK2NM_004972.3(JAK2): c.1849G> T (p.Val617Phe)single nucleotide variantPathogenic, risk factorrs77375493GRCh37Chr 9, 5073770: 5073770
8JAK2NM_004972.3(JAK2): c.1821G> C (p.Lys607Asn)single nucleotide variantPathogenicrs121912472GRCh37Chr 9, 5073742: 5073742
9FLT3NM_004119.2(FLT3): c.2520_2521insGGATCC (p.Ser840_Asn841insGlySer)insertionPathogenicrs398122514GRCh37Chr 13, 28592624: 28592625
10FLT3NM_004119.2(FLT3): c.2504A> T (p.Asp835Val)single nucleotide variantPathogenicrs121909646GRCh37Chr 13, 28592641: 28592641
11FLT3NM_004119.2(FLT3): c.2503G> C (p.Asp835His)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
12FLT3NM_004119.2(FLT3): c.2503G> A (p.Asp835Asn)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
13FLT3FLT3, ASP835GLUundetermined variantPathogenic
14FLT3NM_004119.2(FLT3): c.2503G> T (p.Asp835Tyr)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
15FLT3NM_004119.2(FLT3): c.2503_2505delGAT (p.Asp835del)deletionPathogenicrs121913486GRCh37Chr 13, 28592640: 28592642
16CEBPANM_004364.4(CEBPA): c.115_121delCCCGCGC (p.Pro39Serfs)deletionPathogenicGRCh38Chr 19, 33302294: 33302300
17CEBPANM_004364.4(CEBPA): c.148G> T (p.Glu50Ter)single nucleotide variantPathogenicrs121912791GRCh37Chr 19, 33793173: 33793173
18CEBPANM_004364.4(CEBPA): c.251A> T (p.His84Leu)single nucleotide variantPathogenicrs28931590GRCh37Chr 19, 33793070: 33793070
19CEBPANM_004364.4(CEBPA)duplicationPathogenicGRCh38Chr 19, 33301424: 33301480
20CEBPANM_004364.4(CEBPA)duplicationPathogenicGRCh38Chr 19, 33301464: 33301490
21CEBPANM_004364.4(CEBPA): c.211_214dupGCCG (p.Ala72Glyfs)duplicationPathogenicGRCh38Chr 19, 33302201: 33302204
22CEBPANM_004364.4(CEBPA): c.68delC (p.Pro23Argfs)deletionPathogenicrs137852728GRCh38Chr 19, 33302347: 33302347
23CEBPANM_004364.4(CEBPA): c.141delC (p.Ala48Profs)deletionPathogenicrs137852730GRCh37Chr 19, 33793180: 33793180
24CEBPANM_004364.4(CEBPA): c.198_201dupCTAC (p.Ile68Leufs*41)duplicationPathogenicrs137852731GRCh37Chr 19, 33793120: 33793123
25CEBPANM_004364.4(CEBPA): c.217_218insC (p.Phe73Serfs)insertionPathogenicrs137852733GRCh37Chr 19, 33793103: 33793104
26CEBPANM_004364.4(CEBPA): c.318_319dupTG (p.Asp107Valfs*54)duplicationPathogenicrs137852732GRCh37Chr 19, 33793001: 33793002
27CEBPANM_004364.4(CEBPA): c.68dupC (p.His24Alafs)duplicationPathogenicrs137852729GRCh37Chr 19, 33793252: 33793253
28GATA2NM_001145661.1(GATA2): c.1061C> T (p.Thr354Met)single nucleotide variantPathogenic, risk factorrs387906631GRCh37Chr 3, 128200744: 128200744
29TGM6NM_198994.2(TGM6): c.1550T> G (p.Leu517Trp)single nucleotide variantPathogenicrs387907097GRCh37Chr 20, 2398091: 2398091
30ETV6NM_001987.4(ETV6): c.226G> T (p.Glu76Ter)single nucleotide variantPathogenicrs121434637GRCh37Chr 12, 11992136: 11992136
31ETV6NM_001987.4(ETV6): c.1307_1308insGGG (p.His436delinsGlnGly)insertionPathogenicGRCh37Chr 12, 12043928: 12043929

Expression for genes affiliated with Acute Myeloid Leukemia

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Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia

Search GEO for disease gene expression data for Acute Myeloid Leukemia.

Pathways for genes affiliated with Acute Myeloid Leukemia

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Compounds for genes affiliated with Acute Myeloid Leukemia

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Compounds related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2512.2ARNT, RUNX1, TERT, FLT3, JAK2, ETV6
2tyrosine4411.2RUNX1, TERT, FLT3, JAK2, ETV6, KIT
3oligonucleotide4411.1RUNX1, TERT, FLT3, JAK2, KIT, KRAS
4vegf4411.1RUNX1, TERT, FLT3, JAK2, ETV6, KIT
5estrogen4411.1TERT, JAK2, CEBPA, KIT, KRAS, GATA2
6imatinib44 50 1213.0RUNX1, FLT3, JAK2, ETV6, KIT, KRAS
7leucine4411.0PICALM, JAK2, CEBPA, KIT, GATA2, NPM1
8rapamycin4411.0TERT, FLT3, JAK2, KIT, KRAS, NPM1
9threonine4411.0NPM1, KIT, JAK2, FLT3, TERT, RUNX1
10doxorubicin44 50 1213.0RUNX1, TERT, FLT3, KIT, NPM1
11butyrate4411.0GATA2, KRAS, JAK2, TERT, RUNX1
12arsenite44 2512.0RUNX1, TERT, FLT3, JAK2
13paclitaxel44 50 1212.9NPM1, KRAS, KIT, TERT
14methylcellulose4410.9FLT3, KIT, GATA2
15tandutinib4410.9FLT3, KIT
16zinc44 2511.9RUNX1, TERT, GATA2, NPM1, ARNT
17phosphatidylinositol4410.9TERT, FLT3, JAK2, KIT, KRAS
18leptomycin b44 6011.9NUP214, LPP, NPM1
19beta-tyrosine4410.9KIT, JAK2
20hydroxyurea44 50 1212.9JAK2, KIT, GATA2
21lestaurtinib44 6011.9JAK2, FLT3
22gp 1304410.9KIT, JAK2, FLT3
23phosphoinositide4410.9FLT3, JAK2, KIT, KRAS
24pkc 4124410.8KIT, FLT3
25paraffin4410.8TERT, KIT, KRAS, NPM1
26lactate4410.8FLT3, KIT, NPM1, ARNT
27ag-12964410.8FLT3, KIT
28su54164410.8KIT, FLT3
29agarose4410.8NPM1, KIT, FLT3
30thymidine44 2511.7TERT, FLT3, JAK2, KIT
31ponatinib50 1211.7KIT, FLT3
32aspartate4410.7FLT3, JAK2, KIT, NPM1
335-aza-2deoxycytidine4410.6JAK2, FLT3, TERT
34cycloheximide4410.6NPM1, GATA2, KIT, JAK2
35sunitinib44 50 1212.5FLT3, KIT
36valine4410.5KRAS, KIT, JAK2
37regorafenib50 1211.2KIT, KRAS

GO Terms for genes affiliated with Acute Myeloid Leukemia

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Cellular components related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.8ARNT, PICALM, NUP214, SETBP1, JAK2, CEBPA

Biological processes related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922110.9KRAS, NUP214, FLT3, JAK2, CEBPA, KIT
2hemopoiesisGO:03009710.9RUNX1, PICALM, FLT3, KIT
3myeloid progenitor cell differentiationGO:00231810.9KIT, FLT3, RUNX1
4embryonic placenta developmentGO:00189210.8ARNT, GATA2, CEBPA
5positive regulation of phosphatidylinositol 3-kinase signalingGO:01406810.8FLT3, JAK2, KIT
6peptidyl-tyrosine phosphorylationGO:01810810.8KIT, JAK2, FLT3
7negative regulation of cell proliferationGO:00828510.8NPM1, CEBPA, JAK2, FLT3
8definitive hemopoiesisGO:06021610.8RUNX1, GATA2
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.7JAK2, KIT
10positive regulation of cell proliferationGO:00828410.7FLT3, JAK2, KIT, KRAS
11myeloid cell differentiationGO:03009910.7CEBPA, RUNX1
12embryonic hemopoiesisGO:03516210.6KIT, RUNX1
13positive regulation of erythrocyte differentiationGO:04564810.5ARNT, GATA2
14positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.5KIT, JAK2
15protein autophosphorylationGO:04677710.5FLT3, JAK2, KIT
16positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.2KIT, FLT3

Molecular functions related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.1ARNT, RUNX1, TERT, PICALM, NUP214, FLT3
2protein homodimerization activityGO:04280310.8RUNX1, TERT, FLT3, CEBPA, KIT, NPM1
3transcription factor bindingGO:00813410.7ARNT, GATA2, CEBPA, RUNX1
4protein heterodimerization activityGO:04698210.6RUNX1, CEBPA, NPM1, ARNT
5transmembrane receptor protein tyrosine kinase activityGO:00471410.5KIT, FLT3
6phosphatidylinositol 3-kinase bindingGO:04354810.4JAK2, FLT3
7sequence-specific DNA binding transcription factor activityGO:00370010.3RUNX1, ETV6, CEBPA, GATA2, ARNT

Products for genes affiliated with Acute Myeloid Leukemia

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Sources for Acute Myeloid Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet