AML
MCID: ACT019
MIFTS: 92

Acute Myeloid Leukemia (AML) malady

Genetic diseases, Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Acute Myeloid Leukemia

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34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute myeloid leukemia (aml), there are too many of a specific type of white blood cell called a myeloblast. aml is the most common type of acute leukemia in adults. this type of cancer usually gets worse quickly if it is not treated. possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. symptoms of aml include: fever shortness of breath easy bruising or bleeding bleeding under the skin weakness or feeling tired weight loss or loss of appetite tests that examine the blood and bone marrow diagnose aml. treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Myeloid Leukemia, also known as aml - acute myeloid leukemia, is related to myeloid leukemia and leukemia. An important gene associated with Acute Myeloid Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs cyclophosphamide and etoposide and the compounds retinoic acid and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are mortality/aging and cellular.

Wikipedia:65 Acute myeloid leukemia (AML), also known as acute myelogenous leukemia or acute nonlymphocytic leukemia... more...

Description from OMIM:47 602439,601626

Aliases & Classifications for Acute Myeloid Leukemia

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Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 62UMLS, 22GTR, 9diseasecard, 47OMIM, 43NIH Rare Diseases, 40NCIt, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
acute myeloid leukemia:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

acute myeloid leukemia 8 10 49 34 31
aml - acute myeloid leukemia 8 22
leukemia, acute myeloblastic 9 47
leukemia, myelocytic, acute 8 62
aml 8 49
acute myeloid leukemia without mention of remission 8
acute myeloid leukaemia, disease 8
acute myeloblastic leukemia 8
acute myelogenous leukemia 49
acute myelocytic leukemia 43
leukemia, acute myeloid 47
acute myeloid leukaemia 8
anll in remission 8


External Ids:

Disease Ontology8 DOID:9119
MeSH35 D015470
ICD9CM27 205.0
MESH via Orphanet36 D015470
ICD10 via Orphanet26 C92.0
SNOMED-CT via Orphanet59 103691009, 17788007, 359648001 413443009, 91861009, more
UMLS via Orphanet63 C0023467, C1879321

Related Diseases for Acute Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
Acute Myeloid Leukemia with T(9;11)(p22;q23) Acute Myeloid Leukemia with T(8;16)(p11;p13)
Acute Myeloid Leukemia with T(6;9)(p23;q34)

Diseases related to Acute Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 414)
idRelated DiseaseScoreTop Affiliating Genes
1myeloid leukemia33.0MLF1, FLT3, RUNX1, KIT, NPM1, GATA2
2leukemia32.9ARHGEF12, CEBPA, JAK2, FLT3, SH3GL1, ARNT
3myelodysplastic syndromes32.0SETBP1, GATA2
4sarcoma31.5RUNX1, TERT, JAK2, KIT
5myeloid sarcoma31.5KIT, FLT3
6acute promyelocytic leukemia31.4FLT3, NPM1, RUNX1, GATA2
7acute leukemia31.3KIT, GATA2, MLF1, FLT3, TERT, CEBPA
8mastocytosis31.3KIT, CHIC2
9refractory anemia31.3KIT, RUNX1, JAK2, FLT3
10systemic mastocytosis31.3JAK2, KIT
11chronic myelomonocytic leukemia31.2RUNX1, FLT3, KIT, JAK2
12myelofibrosis31.2JAK2
13breast cancer31.1JAK2, FLT3, RUNX1, KIT, GATA2, NPM1
14down syndrome31.1FLT3, JAK2, RUNX1, GATA2
15myeloproliferative disorder31.1RUNX1, KIT, JAK2, FLT3
16aplastic anemia30.9GATA2, FLT3, TERT
17polycythemia vera30.9KIT, JAK2, FLT3
18acute lymphocytic leukemia30.8PICALM, RUNX1, GATA2, KIT, JAK2, FLT3
19chronic myeloid leukemia30.8GATA2, RUNX1, KIT, JAK2, FLT3
20acute myeloid leukemia, adult30.7SETBP1, JAK2
21juvenile myelomonocytic leukemia30.7RUNX1, FLT3
22retinoblastoma30.6CEBPA, RUNX1, TERT, NPM1
23sotos syndrome30.5WHSC1L1, NSD1
24hemorrhagic thrombocythemia30.4KIT, JAK2
25b-cell lymphomas30.4FLT3, NPM1, JAK2
26cytogenetically normal acute myeloid leukemia11.0
27core binding factor acute myeloid leukemia11.0
28wilms tumor10.8
29endotheliitis10.8
30neutropenia10.8
31hematopoietic stem cell transplantation10.7
32lymphoblastic leukemia10.7
33acute myeloid leukemia with multilineage dysplasia10.7
34aspergillosis10.6
35tetraploidy10.6
36diphtheria10.6
37familial acute myeloid leukemia with mutated cebpa10.6
38mn110.6
39graft versus host disease10.6
40diabetes insipidus10.6
41mediastinitis10.6
42refractory anemia with excess blasts10.6
43invasive aspergillosis10.6
44severe congenital neutropenia10.6
45eosinophilia10.6
46essential thrombocythemia10.6
47thrombocytopenia10.5
48acute myeloid leukemia with t(8;16)(p11;p13)10.5
49chronic lymphocytic leukemia10.5
50hairy cell leukemia10.5

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia:



Diseases related to acute myeloid leukemia

Symptoms for Acute Myeloid Leukemia

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47OMIM
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Symptoms by clinical synopsis from OMIM:

601626

Clinical features from OMIM:

602439,601626

Drugs & Therapeutics for Acute Myeloid Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia

Search NIH Clinical Center for Acute Myeloid Leukemia

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Myeloid Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Myeloid Leukemia

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22GTR
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Genetic tests related to Acute Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Aml - Acute Myeloid Leukemia22

Anatomical Context for Acute Myeloid Leukemia

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Acute Myeloid Leukemia:

33
Myeloid, Bone, Bone marrow, Testes, Skin, T cells, Monocytes, Endothelial, Breast, Nk cells, B cells, Lung, Testis, Thyroid, Liver, Brain, Kidney, Eye, Spleen, Smooth muscle, Small intestine, Pancreas, Colon, Tonsil, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Myeloid Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowCommon Myeloid Progenitor Cells Potential therapeutic candidate, affected by disease
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate

Animal Models for Acute Myeloid Leukemia or affiliated genes

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37MGI
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Publications for Acute Myeloid Leukemia

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52PubMed
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Articles related to Acute Myeloid Leukemia:

(show top 50)    (show all 2874)
idTitleAuthorsYear
1
Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid. (24413389)
2014
2
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
3
Protective effect of cytomegalovirus reactivation on relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia patients is influenced by conditioning regimen. (24120526)
2014
4
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. (24035334)
2013
5
Defining consensus leukemia-associated immunophenotypes for detection of minimal residual disease in acute myeloid leukemia in a multicenter setting. (23912609)
2013
6
Mobilization of CD34(+)CD38(-) hematopoietic stem cells after priming in acute myeloid leukemia. (24179607)
2013
7
Prognostic implication of BAALC gene expression in adult acute myeloid leukemia. (23865362)
2013
8
CAR T cells for acute myeloid leukemia: the LeY of the land. (24201214)
2013
9
Interferon I+ may be back on track to treat acute myeloid leukemia. (23734314)
2013
10
Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia. (23728608)
2013
11
FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013? (24319184)
2013
12
Genetic mutations in patients with acute myeloid leukemia and leukostasis. (23548579)
2013
13
Receptor activator for NF-I_B ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance. (23241893)
2013
14
Rapid screening of ASXL1, IDH1, IDH2, and c-CBL mutations in de novo acute myeloid leukemia by high-resolution melting. (22929312)
2012
15
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease. (21692072)
2012
16
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-I_B and underlies its chemo-resistance. (23077289)
2012
17
High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group. (22915059)
2012
18
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. (22490330)
2012
19
Expression of HtrA2 and WT1 genes in acute myeloid leukemia]. (22391154)
2012
20
DNMT3A mutations are rare in childhood acute myeloid leukemia. (21685466)
2011
21
Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. (21951951)
2011
22
Relapsing acute myeloid leukemia presenting as hypopyon uveitis. (21836350)
2011
23
A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. (21156465)
2010
24
Analysis of CEBPA mutation in acute myeloid leukemia]. (20723288)
2010
25
Peripheral blasts on day 21 of induction chemotherapy in a patient with core binding factor acute myeloid leukemia: more than meets the eye. (20709669)
2010
26
Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. (19637342)
2009
27
CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy. (19092854)
2009
28
Prognostic implication of N-RAS gene mutations in Egyptian adult acute myeloid leukemia. (20726318)
2009
29
An unusual case of febrile neutropenia: acute myeloid leukemia presenting as myeloid sarcoma of the spleen. (18717148)
2008
30
Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. (18768433)
2008
31
Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells. (18616510)
2008
32
Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells. (18268283)
2008
33
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. (18160671)
2008
34
A MLL-KIAA0284 fusion gene in a patient with secondary acute myeloid leukemia and t(11;14)(q23;q32). (18640063)
2008
35
Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia. (18497996)
2008
36
Analysis of NPM1 gene mutations in acute myeloid leukemia]. (17877154)
2007
37
Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia. (17822317)
2007
38
Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (15840695)
2005
39
P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. (15661399)
2005
40
Acute myeloid leukemia associated with necrotizing temporal arteritis. (12672210)
2003
41
Efficacy and toxicity of low-dose melphalan in myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia. (12937849)
2003
42
Concomitant Mycobacterium tuberculosis and Aspergillus niger infection in a patient with acute myeloid leukemia. (14504439)
2003
43
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. (12006512)
2002
44
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML. (11986951)
2002
45
BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. (12145683)
2002
46
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias. (11830484)
2002
47
Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. (11587212)
2001
48
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. (11568008)
2001
49
p91 STAT1 activation in interleukin-3-stimulated primary acute myeloid leukemia cells. (8806691)
1996
50
Rearrangements and fusion gene of AML1 and MTG8 in acute myeloid leukemia M2b]. (7553157)
1995

Variations for Acute Myeloid Leukemia

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Acute Myeloid Leukemia:

64
id Symbol AA change Variation ID SNP ID
1JAK2p.Lys607AsnVAR_032696
2JAK2p.Val617PheVAR_032697
3SETBP1p.Gly870SerVAR_063809
4SETBP1p.Ser854AlaVAR_069848
5SETBP1p.Gly870ArgVAR_069854
6SETBP1p.Ile871SerVAR_069856

Clinvar genetic disease variations for Acute Myeloid Leukemia:

1 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1KRASKRAS, 3-BP INS, GLY11INSinsertionPathogenic
2KITNM_000222.2(KIT): c.2446G> T (p.Asp816Tyr)single nucleotide variantPathogenicrs121913506GRCh37Chr 4, 55599320: 55599320
3NPM1NM_002520.6(NPM1): c.860_863dupTCTG (p.Trp288Cysfs)duplicationPathogenicGRCh38Chr 5, 171410540: 171410543
4NPM1NM_002520.6(NPM1): c.863_864insCATG (p.Trp288Cysfs)insertionPathogenicGRCh38Chr 5, 171410543: 171410544
5NPM1NM_002520.6(NPM1): c.863_864insCGTG (p.Trp288Cysfs)insertionPathogenicGRCh38Chr 5, 171410543: 171410544
6NPM1NM_002520.6(NPM1): c.863_864insCCTG (p.Trp288Cysfs)insertionPathogenicGRCh38Chr 5, 171410543: 171410544
7JAK2NM_004972.3(JAK2): c.1849G> T (p.Val617Phe)single nucleotide variantPathogenic, risk factorrs77375493GRCh37Chr 9, 5073770: 5073770
8JAK2NM_004972.3(JAK2): c.1821G> C (p.Lys607Asn)single nucleotide variantPathogenicrs121912472GRCh37Chr 9, 5073742: 5073742
9FLT3NM_004119.2(FLT3): c.2520_2521insGGATCC (p.Ser840_Asn841insGlySer)insertionPathogenicrs398122514GRCh37Chr 13, 28592624: 28592625
10FLT3NM_004119.2(FLT3): c.2504A> T (p.Asp835Val)single nucleotide variantPathogenicrs121909646GRCh37Chr 13, 28592641: 28592641
11FLT3NM_004119.2(FLT3): c.2503G> C (p.Asp835His)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
12FLT3NM_004119.2(FLT3): c.2503G> A (p.Asp835Asn)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
13FLT3FLT3, ASP835GLUundetermined variantPathogenic
14FLT3NM_004119.2(FLT3): c.2503G> T (p.Asp835Tyr)single nucleotide variantPathogenicrs121913488GRCh37Chr 13, 28592642: 28592642
15FLT3NM_004119.2(FLT3): c.2503_2505delGAT (p.Asp835del)deletionPathogenicrs121913486GRCh37Chr 13, 28592640: 28592642
16CEBPANM_004364.4(CEBPA): c.115_121delCCCGCGC (p.Pro39Serfs)deletionPathogenicGRCh38Chr 19, 33302294: 33302300
17CEBPANM_004364.4(CEBPA): c.148G> T (p.Glu50Ter)single nucleotide variantPathogenicrs121912791GRCh37Chr 19, 33793173: 33793173
18CEBPANM_004364.4(CEBPA): c.251A> T (p.His84Leu)single nucleotide variantPathogenicrs28931590GRCh37Chr 19, 33793070: 33793070
19CEBPANM_004364.4(CEBPA): c.935_991dup57 (p.Gln330_Leu331insGlnLysValLeuGluLeuThrSerAspAsnAspArgLeuArgLysArgValGluGln)duplicationPathogenicGRCh38Chr 19, 33301424: 33301480
20CEBPANM_004364.4(CEBPA): c.925_951dup27 (p.Leu317_Thr318insGluThrGlnGlnLysValLeuGluLeu)duplicationPathogenicGRCh38Chr 19, 33301464: 33301490
21CEBPANM_004364.4(CEBPA): c.211_214dupGCCG (p.Ala72Glyfs)duplicationPathogenicGRCh38Chr 19, 33302201: 33302204
22CEBPANM_004364.4(CEBPA): c.68delC (p.Pro23Argfs)deletionPathogenicrs137852728GRCh38Chr 19, 33302347: 33302347
23CEBPANM_004364.4(CEBPA): c.141delC (p.Ala48Profs)deletionPathogenicrs137852730GRCh37Chr 19, 33793180: 33793180
24CEBPANM_004364.4(CEBPA): c.198_201dupCTAC (p.Ile68Leufs*41)duplicationPathogenicrs137852731GRCh37Chr 19, 33793120: 33793123
25CEBPANM_004364.4(CEBPA): c.217_218insC (p.Phe73Serfs)insertionPathogenicrs137852733GRCh37Chr 19, 33793103: 33793104
26CEBPANM_004364.4(CEBPA): c.318_319dupTG (p.Asp107Valfs*54)duplicationPathogenicrs137852732GRCh37Chr 19, 33793001: 33793002
27CEBPANM_004364.4(CEBPA): c.68dupC (p.His24Alafs)duplicationPathogenicrs137852729GRCh37Chr 19, 33793252: 33793253
28GATA2NM_001145661.1(GATA2): c.1061C> T (p.Thr354Met)single nucleotide variantPathogenic, risk factorrs387906631GRCh37Chr 3, 128200744: 128200744
29TGM6NM_198994.2(TGM6): c.1550T> G (p.Leu517Trp)single nucleotide variantPathogenicrs387907097GRCh37Chr 20, 2398091: 2398091
30TERTNM_198253.2(TERT): c.3184G> A (p.Ala1062Thr)single nucleotide variantPathogenic, risk factorrs35719940GRCh37Chr 5, 1254594: 1254594
31ETV6NM_001987.4(ETV6): c.226G> T (p.Glu76Ter)single nucleotide variantPathogenicrs121434637GRCh37Chr 12, 11992136: 11992136
32ETV6NM_001987.4(ETV6): c.1307_1308insGGG (p.His436delinsGlnGly)insertionPathogenicGRCh37Chr 12, 12043928: 12043929

Expression for genes affiliated with Acute Myeloid Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia

Search GEO for disease gene expression data for Acute Myeloid Leukemia.

Pathways for genes affiliated with Acute Myeloid Leukemia

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Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 5Cell Signaling Technology, 38NCBI BioSystems Database
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Pathways related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6RUNX1, FLT3, CEBPA, KIT, ARNT
2
Show member pathways
Signal transduction PTEN pathway60
10.6RUNX1, FLT3, CEBPA, KIT
310.6RUNX1, CEBPA, KIT, GATA2
410.6CEBPA, FLT3, MLF1, RUNX1
510.6NPM1, KIT, JAK2, FLT3
610.6ARNT, NPM1, GATA2, TERT

Compounds for genes affiliated with Acute Myeloid Leukemia

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Sources:
45Novoseek, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.1ARNT, RUNX1, TERT, FLT3, JAK2, CEBPA
2oligonucleotide4511.0RUNX1, TERT, FLT3, JAK2, KIT, GATA2
3tyrosine4511.0RUNX1, TERT, FLT3, JAK2, KIT, NPM1
4estrogen4511.0TERT, JAK2, CEBPA, KIT, GATA2, NPM1
5leucine4511.0PICALM, JAK2, CEBPA, KIT, GATA2, NPM1
6doxorubicin45 51 1113.0RUNX1, TERT, FLT3, KIT, NPM1
7vegf4511.0RUNX1, TERT, FLT3, JAK2, KIT, ARNT
8rapamycin4511.0TERT, FLT3, JAK2, KIT, NPM1
9threonine4511.0RUNX1, TERT, FLT3, JAK2, KIT, NPM1
10imatinib45 51 1112.9RUNX1, FLT3, JAK2, KIT
11arsenite45 2411.9RUNX1, TERT, FLT3, JAK2
12tandutinib4510.9KIT, FLT3
13methylcellulose4510.9GATA2, KIT, FLT3
14beta-tyrosine4510.9KIT, JAK2
15butyrate4510.9GATA2, JAK2, TERT, RUNX1
16leptomycin b45 6111.9NUP214, LPP, NPM1
17zinc45 2411.8RUNX1, TERT, GATA2, NPM1, ARNT
18lestaurtinib45 6111.8JAK2, FLT3
19hydroxyurea45 51 1112.8JAK2, KIT, GATA2
20gp 1304510.8KIT, JAK2, FLT3
21pkc 4124510.8KIT, FLT3
22lactate4510.8FLT3, KIT, NPM1, ARNT
23ag-12964510.8KIT, FLT3
24su54164510.7KIT, FLT3
25agarose4510.7NPM1, KIT, FLT3
26thymidine45 2411.7TERT, FLT3, JAK2, KIT
27ponatinib51 1111.7KIT, FLT3
28aspartate4510.6NPM1, KIT, JAK2, FLT3
29cycloheximide4510.6NPM1, GATA2, KIT, JAK2
305-aza-2deoxycytidine4510.5TERT, FLT3, JAK2
31sunitinib45 51 1112.4KIT, FLT3
32l-lysine29 24 1112.2WHSC1L1, NSD1

GO Terms for genes affiliated with Acute Myeloid Leukemia

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16Gene Ontology
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Cellular components related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.6ARNT, NPM1, GATA2, NUP214, TERT
2nucleusGO:00563410.4ARNT, RUNX1, PICALM, MLF1, NUP214, SETBP1

Biological processes related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922110.9JAK2, NUP214, KIT, CEBPA, FLT3
2transcription, DNA-templatedGO:00635110.9ARNT, GATA2, CEBPA, NSD1, MLF1, RUNX1
3myeloid progenitor cell differentiationGO:00231810.9MLF1, RUNX1, KIT, FLT3
4hemopoiesisGO:03009710.9PICALM, FLT3, KIT, RUNX1
5embryonic placenta developmentGO:00189210.8ARNT, CEBPA, GATA2
6positive regulation of phosphatidylinositol 3-kinase signalingGO:01406810.8KIT, JAK2, FLT3
7peptidyl-tyrosine phosphorylationGO:01810810.8KIT, JAK2, FLT3
8negative regulation of cell proliferationGO:00828510.8CEBPA, NPM1, FLT3, JAK2
9definitive hemopoiesisGO:06021610.8GATA2, RUNX1
10histone methylationGO:01657110.7WHSC1L1, NSD1
11positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.7JAK2, KIT
12myeloid cell differentiationGO:03009910.7RUNX1, CEBPA
13embryonic hemopoiesisGO:03516210.6RUNX1, KIT
14positive regulation of erythrocyte differentiationGO:04564810.6ARNT, GATA2
15protein autophosphorylationGO:04677710.5FLT3, JAK2, KIT
16positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.5JAK2, KIT
17positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.4FLT3, KIT
18positive regulation of transcription, DNA-templatedGO:04589310.3ARNT, PICALM, RUNX1, NSD1

Molecular functions related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0TERT, RUNX1, PICALM, MLF1, NUP214, SH3GL1
2protein homodimerization activityGO:04280310.7RUNX1, TERT, FLT3, CEBPA, KIT, NPM1
3transcription factor bindingGO:00813410.6RUNX1, CEBPA, GATA2, ARNT
4transmembrane receptor protein tyrosine kinase activityGO:00471410.5FLT3, KIT
5protein heterodimerization activityGO:04698210.5CEBPA, NPM1, ARNT, RUNX1
6phosphatidylinositol 3-kinase bindingGO:04354810.2FLT3, JAK2

Products for genes affiliated with Acute Myeloid Leukemia

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Sources for Acute Myeloid Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
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37MGI
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41NDF-RT
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53QIAGEN
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