AML
MCID: ACT019
MIFTS: 94

Acute Myeloid Leukemia (AML) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Acute Myeloid Leukemia

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute myeloid leukemia (aml), there are too many of a specific type of white blood cell called a myeloblast. aml is the most common type of acute leukemia in adults. this type of cancer usually gets worse quickly if it is not treated. possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. symptoms of aml include: fever shortness of breath easy bruising or bleeding bleeding under the skin weakness or feeling tired weight loss or loss of appetite tests that examine the blood and bone marrow diagnose aml. treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Myeloid Leukemia, also known as aml - acute myeloid leukemia, is related to leukemia and acute leukemia. An important gene associated with Acute Myeloid Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs cyclophosphamide and etoposide and the compounds retinoic acid and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are mortality/aging and cellular.

Wikipedia:63 Acute myeloid leukemia (AML), also known as acute myelogenous leukemia or acute nonlymphocytic leukemia... more...

Description from OMIM:46 602439,601626

Aliases & Classifications for Acute Myeloid Leukemia

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8Disease Ontology, 10DISEASES, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 22GTR, 60UMLS, 9diseasecard, 46OMIM, 42NIH Rare Diseases, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acute myeloid leukemia:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

acute myeloid leukemia 8 10 48 33 30
aml - acute myeloid leukemia 8 22
leukemia, acute myeloblastic 9 46
leukemia, myelocytic, acute 8 60
aml 8 48
acute myeloid leukemia without mention of remission 8
acute non-lymphoblastic leukemia 48
acute myeloid leukaemia, disease 8
acute myeloblastic leukemia 8
acute myelogenous leukemia 48
acute myelocytic leukemia 42
acute myeloid leukaemia 8
leukemia, acute myeloid 46
anll in remission 8


External Ids:

Disease Ontology8 DOID:9119
MeSH34 D015470
ICD9CM27 205.0
MESH via Orphanet35 D015470
ICD10 via Orphanet26 C92.0
SNOMED-CT via Orphanet57 103691009, 17788007, 359648001 413443009, 91861009, more
UMLS via Orphanet61 C0023467, C1879321

Related Diseases for Acute Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia

Diseases related to Acute Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 369)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.8ARNT, ARHGEF12, PICALM, FLT3, MLF1, SH3GL1
2acute leukemia32.7RUNX1, NPM1, JAK2, GATA2, FLT3, MLF1
3myeloid leukemia32.7RUNX1, NPM1, JAK2, GATA2, PICALM, FLT3
4myeloid sarcoma31.3KIT, FLT3
5sarcoma31.3RUNX1, JAK2, KIT, TERT
6chronic myeloid leukemia31.3RUNX1, JAK2, GATA2, FLT3, KIT
7acute lymphocytic leukemia31.1RUNX1, JAK2, GATA2, PICALM, FLT3, KIT
8breast cancer31.0RUNX1, NPM1, JAK2, GATA2, ARNT, FLT3
9systemic mastocytosis31.0JAK2, KIT
10myelofibrosis30.9KIT, JAK2
11down syndrome30.8RUNX1, JAK2, GATA2, FLT3
12aplastic anemia30.7TERT, FLT3, GATA2
13polycythemia30.7JAK2
14polycythemia vera30.6JAK2, FLT3, KIT
15thrombocytosis30.6FLT3, JAK2
16acute myeloid leukemia, adult30.5RUNX1, NPM1, FLT3, KIT
17acute promyelocytic leukemia30.5RUNX1, NPM1, GATA2, FLT3
18retinoblastoma30.4CEBPA, TERT, NPM1, RUNX1
19juvenile myelomonocytic leukemia30.4RUNX1, FLT3
20gastrointestinal stromal tumor30.4KIT, FLT3
21hepatocellular carcinoma29.7RUNX1, NPM1, TERT
22childhood leukemia11.0
23acute t cell leukemia11.0
24t-cell leukemia10.8
25acute monocytic leukemia10.8
26monocytic leukemia10.8
27lymphoblastic leukemia10.7
28neutropenia10.7
29familial acute myeloid leukemia with mutated cebpa10.7
30lymphoid leukemia10.7
31cytogenetically normal acute myeloid leukemia10.6
32diphtheria10.6
33mast-cell leukemia10.6
34aspergillosis10.6
35core binding factor acute myeloid leukemia10.6
36graft versus host disease10.6
37diabetes insipidus10.6
38invasive aspergillosis10.6
39mediastinitis10.6
40severe congenital neutropenia10.5
41natural killer cell leukemia10.5
42chronic lymphocytic leukemia10.5
43eosinophilia10.5
44acute myeloblastic leukemia without maturation10.5
45central nervous system leukemia10.5
46thrombocytopenia10.5
47hairy cell leukemia10.4
48multiple myeloma10.4
49myeloma10.4
50minimally differentiated acute myeloblastic leukemia10.4

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia:



Diseases related to acute myeloid leukemia

Clinical Features for Acute Myeloid Leukemia

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46OMIM
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Clinical features from OMIM:

602439,601626

Clinical synopsis from OMIM:

601626

Drugs & Therapeutics for Acute Myeloid Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia

Search NIH Clinical Center for Acute Myeloid Leukemia

Search CenterWatch for Acute Myeloid Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Myeloid Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Myeloid Leukemia

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22GTR
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Genetic tests related to Acute Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Aml - Acute Myeloid Leukemia22

Anatomical Context for Acute Myeloid Leukemia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Acute Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, T cells, Testes, Skin, Monocytes, Endothelial, Breast, Nk cells, B cells, Lung, Testis, Thyroid, Liver, Kidney, Brain, Eye, Spleen, Smooth muscle, Small intestine, Colon, Tonsil, Pancreas, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Myeloid Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowCommon Myeloid Progenitor Cells Potential therapeutic candidate, affected by disease
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate

Animal Models for Acute Myeloid Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Myeloid Leukemia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076813.2CEBPA, RUNX1, NSD1, NPM1, JAK2, GATA2
2MP:000538412.9RUNX1, NPM1, JAK2, GATA2, ARNT, ARHGEF12
3MP:000537812.6ARNT, GATA2, JAK2, NPM1, RUNX1, ARHGEF12
4MP:000539712.5RUNX1, NPM1, JAK2, GATA2, ARNT, ARHGEF12
5MP:000538712.2RUNX1, NPM1, JAK2, ARNT, ARHGEF12, PICALM
6MP:000200612.0RUNX1, NPM1, JAK2, ARNT, FLT3, KIT
7MP:000287311.7RUNX1, JAK2, GATA2, ARNT, SH3GL1, KIT
8MP:000537011.7RUNX1, NPM1, GATA2, ARNT, PICALM, KIT
9MP:000538911.6GATA2, ARNT, LPP, KIT, TERT, CEBPA
10MP:000537611.4RUNX1, GATA2, ARNT, PICALM, LPP, FLT3
11MP:000538010.8ARNT

Publications for Acute Myeloid Leukemia

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50PubMed
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Articles related to Acute Myeloid Leukemia:

(show top 50)    (show all 3054)
idTitleAuthorsYear
1
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
2
Prognostic impact of the number of methylated genes in myelodysplastic syndromes and acute myeloid leukemias treated with azacytidine. (23740492)
2013
3
AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia. (23492767)
2013
4
KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement. (23053179)
2013
5
Durable second complete remissions with oral melphalan in hypocellular Acute Myeloid Leukemia and Refractory Anemia with Excess Blast with normal karyotype relapsing after intensive chemotherapy. (24371768)
2013
6
A case of acute myeloid leukemia (AML) with an unreported combination of chromosomal abnormalities: gain of isochromosome 5p, tetrasomy 8 and unbalanced translocation der(19)t(17;19)(q23;p13). (24079663)
2013
7
Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels. (23357299)
2013
8
Medicare fee-for-service enrollees with primary acute myeloid leukemia: an analysis of treatment patterns, survival, and healthcare resource utilization and costs. (23677706)
2013
9
Vascular endothelial growth factor signaling in acute myeloid leukemia. (22833169)
2013
10
Mutation of the NPM1 gene contributes to the development of donor cell-derived acute myeloid leukemia after unrelated cord blood transplantation for acute lymphoblastic leukemia. (23465275)
2013
11
Antifungal prophylaxis with posaconazole in patients with acute myeloid leukemia: dose intensification coupled with avoidance of proton pump inhibitors is beneficial in shortening time to effective concentrations. (24060872)
2013
12
Rare cytogenetic abnormalities in acute myeloid leukemia transformed from Fanconi anemia -- a case report. (23937881)
2013
13
Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis. (24030154)
2013
14
The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression. (23398943)
2013
15
Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). (22284693)
2012
16
Negative impact of FLT3-ITD mutation on expression of MDR-1 mRNA in adult acute myeloid leukemia. (22591177)
2012
17
Relapsing acute myeloid leukemia presenting as hypopyon uveitis. (21836350)
2011
18
Novel variant form of t(11;22)(q23;q13)/MLL-EP300 fusion transcript in the evolution of an acute myeloid leukemia with myelodysplasia-related changes. (20980053)
2011
19
Recurrent pericarditis after chemotherapy for acute myeloid leukemia: a case report and a modern approach to chemotherapy-induced pericarditis. (22179126)
2011
20
Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity? (21030560)
2011
21
Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans. (20438363)
2010
22
NF-kappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction. (20332229)
2010
23
Cladribine in the treatment of acute myeloid leukemia: a single-institution experience. (19717379)
2009
24
Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia. (19652057)
2009
25
Systemic mastocytosis associated with t(8;21)(q22;q22) acute myeloid leukemia. (19669220)
2009
26
The role of myeloid growth factors in acute leukemia. (19176208)
2009
27
Very early onset of an acute myeloid leukemia in an adult patient with B-cell lymphoblastic leukemia. (19143872)
2009
28
CCAAT/enhancer binding protein-alpha polymorphisms occur more frequently than mutations in acute myeloid leukemia and exist across all cytogenetic risk groups and leukemia subtypes. (18729193)
2008
29
A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia. (18765556)
2008
30
Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia. (18981008)
2008
31
PRAME mRNA expression in newly diagnosed acute myeloid leukemia patients and its application to monitoring minimal residual disease]. (19035174)
2008
32
Analysis of Flt-3 expression and Flt-3/ITD mutation in acute myeloid leukemia cells]. (16800917)
2006
33
Three-way translocation involves MLL, MLLT3, and a novel cell cycle control gene, FLJ10374, in the pathogenesis of acute myeloid leukemia with t(9;11;19)(p22;q23;p13.3). (16450356)
2006
34
Detailed analysis of FLT3 expression levels in acute myeloid leukemia. (16330434)
2005
35
Acute myeloid leukemia cells in G0 phase of the cell cycle that are unresponsive to conventional chemotherapy are sensitive to treatment with granulocyte-macrophage colony-stimulating factor/diphtheria toxin fusion proteins. (15102480)
2004
36
Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia. (12930926)
2003
37
Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. (12689943)
2003
38
FLAG-IDA in the treatment of refractory/relapsed acute myeloid leukemia: single-center experience. (12707726)
2003
39
Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid leukemia-derived cell lines. (11755471)
2002
40
More cell death in refractory anemia with excess blasts in transformation than in acute myeloid leukemia. (12399969)
2002
41
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia. (11568008)
2001
42
Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. (11320212)
2001
43
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. (11001933)
2000
44
A unique structural abnormality of chromosome 16 resulting in a CBF beta-MYH11 fusion transcript in a patient with acute myeloid leukemia, FAB M4. (10958941)
2000
45
Chromosomal alterations associated with evolution from myelodysplastic syndrome to acute myeloid leukemia. (10996202)
2000
46
CD8(+) minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate human acute myeloid leukemia stem cells. (10411928)
1999
47
Rearrangement between the MYH11 gene at 16p13 and D12S158 at 12p13 in a case of acute myeloid leukemia M1 (AML-M1). (9713991)
1998
48
Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells. (8643682)
1996
49
Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. (8700862)
1996
50
Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. (1384791)
1992

Genetic Variations for Acute Myeloid Leukemia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute Myeloid Leukemia:

62
id Symbol AA change Variation ID SNP ID
1JAK2p.Lys607AsnVAR_032696
2JAK2p.Val617PheVAR_032697
3SETBP1p.Gly870SerVAR_063809
4SETBP1p.Ser854AlaVAR_069848
5SETBP1p.Gly870ArgVAR_069854
6SETBP1p.Ile871SerVAR_069856

Expression for genes affiliated with Acute Myeloid Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia

Search GEO for disease gene expression data for Acute Myeloid Leukemia.

Pathways for genes affiliated with Acute Myeloid Leukemia

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29KEGG, 4Cell Signaling Technology, 37NCBI BioSystems Database
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Pathways related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3RUNX1, ARNT, FLT3, KIT, CEBPA
2
Hide members
11.1RUNX1, FLT3, KIT, CEBPA
311.1RUNX1, GATA2, KIT, CEBPA
411.1CEBPA, MLF1, FLT3, RUNX1
511.1KIT, FLT3, JAK2, NPM1
611.1TERT, ARNT, GATA2, NPM1

Compounds for genes affiliated with Acute Myeloid Leukemia

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.3CEBPA, RUNX1, NPM1, JAK2, GATA2, ARNT
2oligonucleotide4412.2RUNX1, JAK2, GATA2, ARNT, ARHGEF12, FLT3
3tyrosine4412.0RUNX1, NPM1, JAK2, ARNT, ARHGEF12, FLT3
4leucine4411.8NPM1, JAK2, GATA2, PICALM, KIT, CEBPA
5vegf4411.7RUNX1, JAK2, ARNT, FLT3, KIT, TERT
6threonine4411.6RUNX1, NPM1, JAK2, FLT3, KIT, TERT
7rapamycin4411.6NPM1, JAK2, FLT3, KIT, TERT
8doxorubicin44 49 1113.6TERT, KIT, FLT3, NPM1, RUNX1
9imatinib44 49 1113.4RUNX1, JAK2, FLT3, KIT
10arsenite44 2412.4RUNX1, JAK2, FLT3, TERT
11butyrate4411.3RUNX1, JAK2, GATA2, TERT
12methylcellulose4411.2GATA2, FLT3, KIT
13leptomycin b44 5912.2NPM1, LPP, NUP214
14tandutinib4411.1KIT, FLT3
15beta-tyrosine4411.1JAK2, KIT
16lestaurtinib44 5912.1FLT3, JAK2
17hydroxyurea44 49 1113.0KIT, GATA2, JAK2
18gp 1304410.9JAK2, FLT3, KIT
19pkc 4124410.9KIT, FLT3
20su54164410.8KIT, FLT3
21ag-12964410.5KIT, FLT3

GO Terms for genes affiliated with Acute Myeloid Leukemia

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16Gene Ontology
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Cellular components related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.7WHSC1L1, NSD1, NPM1, JAK2, GATA2, ARNT

Biological processes related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922111.6JAK2, FLT3, NUP214, KIT, CEBPA
2myeloid progenitor cell differentiationGO:00231811.4KIT, MLF1, FLT3, RUNX1
3hemopoiesisGO:03009711.4RUNX1, PICALM, FLT3, KIT
4embryonic placenta developmentGO:00189211.2CEBPA, ARNT, GATA2
5positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.2KIT, FLT3, JAK2
6peptidyl-tyrosine phosphorylationGO:01810811.2JAK2, FLT3, KIT
7negative regulation of cell proliferationGO:00828511.0CEBPA, FLT3, JAK2, NPM1
8histone methylationGO:01657111.0WHSC1L1, NSD1
9definitive hemopoiesisGO:06021610.9GATA2, RUNX1
10positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9KIT, JAK2
11myeloid cell differentiationGO:03009910.8RUNX1, CEBPA
12positive regulation of erythrocyte differentiationGO:04564810.8ARNT, GATA2
13embryonic hemopoiesisGO:03516210.5KIT, RUNX1

Molecular functions related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.3WHSC1L1, RUNX1, NPM1, JAK2, GATA2, ARNT
2protein homodimerization activityGO:04280311.4RUNX1, NPM1, FLT3, KIT, TERT, CEBPA
3transcription factor bindingGO:00813410.8CEBPA, ARNT, GATA2, RUNX1
4phosphatidylinositol 3-kinase bindingGO:04354810.8FLT3, JAK2

Products for genes affiliated with Acute Myeloid Leukemia

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  • Antibodies
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Sources for Acute Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet