AML
MCID: ACT019
MIFTS: 87

Acute Myeloid Leukemia (AML) malady

Blood, Cancer, Immune categories

Summaries for Acute Myeloid Leukemia

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute myeloid leukemia (aml), there are too many of a specific type of white blood cell called a myeloblast. aml is the most common type of acute leukemia in adults. this type of cancer usually gets worse quickly if it is not treated. possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. symptoms of aml include: fever shortness of breath easy bruising or bleeding bleeding under the skin weakness or feeling tired weight loss or loss of appetite tests that examine the blood and bone marrow diagnose aml. treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Myeloid Leukemia, also known as aml - acute myeloid leukemia, is related to acute leukemia and acute myeloid leukemia, adult. An important gene associated with Acute Myeloid Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs cyclophosphamide and etoposide and the compounds retinoic acid and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are mortality/aging and cellular.

Wikipedia:64 Acute myeloid leukemia (AML), also known as acute myelogenous leukemia or acute nonlymphocytic leukemia... more...

Description from OMIM:47 602439,601626,252270

Aliases & Classifications for Acute Myeloid Leukemia

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 47OMIM, 34MedlinePlus, 31LifeMap Discovery™, 22GTR, 61UMLS, 9diseasecard, 43NIH Rare Diseases, 35MeSH, 40NCIt, 57SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
acute myeloid leukemia:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

acute myeloid leukemia 8 10 49 47 34 31
aml - acute myeloid leukemia 8 22
leukemia, acute myeloblastic 9 47
leukemia, myelocytic, acute 8 61
aml 8 49
acute myeloid leukemia without mention of remission 8
acute non-lymphoblastic leukemia 49
acute myeloid leukaemia, disease 8
acute myeloblastic leukemia 8
acute myelogenous leukemia 49
acute myelocytic leukemia 43
acute myeloid leukaemia 8
leukemia, acute myeloid 47
anll in remission 8


External Ids:

Disease Ontology8 DOID:9119
MeSH35 D015470
ICD9CM27 205.0
MESH via Orphanet36 D015470
ICD10 via Orphanet26 C92.0
SNOMED-CT via Orphanet58 103691009, 17788007, 359648001 413443009, 91861009, more
UMLS via Orphanet62 C0023467, C1879321

Related Diseases for Acute Myeloid Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acute Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 368)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.8RUNX1, NPM1, JAK2, GATA2, FLT3, MLF1
2acute myeloid leukemia, adult31.8RUNX1, NPM1, FLT3, KIT
3myelodysplastic syndromes31.6RUNX1, NPM1, JAK2, GATA2, FLT3, MLF1
4myeloid sarcoma31.3KIT, FLT3
5chronic myeloid leukemia31.3RUNX1, JAK2, GATA2, FLT3, KIT
6acute promyelocytic leukemia31.2RUNX1, NPM1, GATA2, FLT3
7wilms tumor31.2FLT3
8mastocytosis31.1KIT, CHIC2
9systemic mastocytosis31.0JAK2, KIT
10refractory anemia31.0RUNX1, JAK2, FLT3, KIT
11chronic myelomonocytic leukemia31.0RUNX1, JAK2, FLT3, KIT
12acute lymphocytic leukemia30.9RUNX1, JAK2, GATA2, PICALM, FLT3, KIT
13myeloproliferative disorder30.8KIT, FLT3, JAK2, RUNX1
14aplastic anemia30.7TERT, FLT3, GATA2
15polycythemia vera30.6JAK2, FLT3, KIT
16thrombocytosis30.6FLT3, JAK2
17down syndrome30.4RUNX1, JAK2, GATA2, FLT3
18juvenile myelomonocytic leukemia30.4RUNX1, FLT3
19gastrointestinal stromal tumor30.4KIT, FLT3
20acute t cell leukemia11.3
21t-cell leukemia11.3
22acute myeloid leukemia, childhood11.0
23core binding factor acute myeloid leukemia11.0
24leukemia, acute myeloid, therapy-related11.0
25n syndrome10.9
26acute myelomonocytic leukemia10.8
27acute monocytic leukemia10.7
28hematopoietic stem cell transplantation10.7
29lymphoid leukemia10.7
30leukemia, acute myeloid, somatic10.7
31familial acute myeloid leukemia with mutated cebpa10.7
32diphtheria10.6
33mast-cell leukemia10.6
34aspergillosis10.6
35tetraploidy10.6
36graft versus host disease10.6
37diabetes insipidus10.6
38invasive aspergillosis10.6
39acute graft versus host disease10.6
40essential thrombocythemia10.6
41plasma cell leukemia10.6
42leukemia, acute pre-b-cell10.6
43severe congenital neutropenia10.5
44natural killer cell leukemia10.5
45acute myeloblastic leukemia without maturation10.5
46central nervous system leukemia10.5
47thrombocytopenia10.5
48acute erythroid leukemia10.5
49bone marrow necrosis10.5
50minimally differentiated acute myeloblastic leukemia10.4

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia:



Diseases related to acute myeloid leukemia

Clinical Features for Acute Myeloid Leukemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

602439,601626,252270

Clinical synopsis from OMIM:

252270

Drugs & Therapeutics for Acute Myeloid Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia

Search NIH Clinical Center for Acute Myeloid Leukemia

Search CenterWatch for Acute Myeloid Leukemia

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Myeloid Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Myeloid Leukemia

Sources:
22GTR
See all sources

Genetic tests related to Acute Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Aml - Acute Myeloid Leukemia22

Anatomical Context for Acute Myeloid Leukemia

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Acute Myeloid Leukemia:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Spleen, Bone marrow, Whole blood, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Testis, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Pituitary, Testis germ

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Myeloid Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowCommon Myeloid Progenitor Cells Potential therapeutic candidate, affected by disease
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate

Animal Models for Acute Myeloid Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acute Myeloid Leukemia

Sources:
51PubMed
See all sources

Articles related to Acute Myeloid Leukemia:

(show top 50)    (show all 3058)
idTitleAuthorsYear
1
Receptor activator for NF-I_B ligand in acute myeloid leukemia: expression, function, and modulation of NK cell immunosurveillance. (23241893)
2013
2
Voltage-gated potassium channel antibody paraneoplastic limbic encephalitis associated with acute myeloid leukemia. (23898271)
2013
3
Busulfan plus fludarabine as a myeloablative conditioning regimen compared with busulfan plus cyclophosphamide for acute myeloid leukemia in first complete remission undergoing allogeneic hematopoietic stem cell transplantation: a prospective and multicenter study. (23394705)
2013
4
Clinicopathologic analysis of acute myeloid leukemia arising from chronic myelomonocytic leukemia. (23307061)
2013
5
Acute myeloid leukemia in the elderly: do we know who should be treated and how? (23885839)
2013
6
DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia. (23741974)
2013
7
Therapy-related myelodysplasia and acute myeloid leukemia. (24331189)
2013
8
Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group. (24039149)
2013
9
SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia. (22873195)
2012
10
Detection of IDH1 R132H mutation in acute myeloid leukemia by mutation-specific immunohistochemistry. (22172803)
2012
11
MLL partner genes drive distinct gene expression profiles and genomic alterations in pediatric acute myeloid leukemia: an AIEOP study. (21331072)
2011
12
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. (21813447)
2011
13
Simultaneous tumors: acute myeloid leukemia infiltrating mediastinal ganglioneuroblastoma. (20973101)
2011
14
Candida albicans cervical lymphadenitis in patients who have acute myeloid leukemia. (21816377)
2011
15
FLT3 and NPM1 mutations in myelodysplastic syndromes: Frequency and potential value for predicting progression to acute myeloid leukemia. (21173125)
2011
16
Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. (21625234)
2011
17
Correlation between IDH2 mutations and disease status in acute myeloid leukemia. (20929316)
2010
18
Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. (20368538)
2010
19
Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome. (20038735)
2010
20
Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics. (19490647)
2009
21
Relapsed acute myeloid leukemia with Down syndrome showing long disease-free survival after bone marrow transplantation]. (19265297)
2009
22
Activation of Wnt signaling in cKit-ITD mediated transformation and imatinib sensitivity in acute myeloid leukemia. (18668305)
2008
23
Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4. (19020754)
2008
24
A critical role for Lyn in acute myeloid leukemia. (18056483)
2008
25
Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. (18523155)
2008
26
Analysis of NPM1 gene mutations in acute myeloid leukemia]. (17877154)
2007
27
Cytotoxic activity of the third-generation bisphosphonate zoledronic acid in acute myeloid leukemia. (16939689)
2007
28
Validation of an interphase fluorescence in situ hybridization approach for the detection of MLL gene rearrangements and of the MLL/AF9 fusion in acute myeloid leukemia. (16503549)
2006
29
Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. (16688229)
2006
30
Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. (16847333)
2006
31
Constitutive phosphoinositide 3-kinase activation in acute myeloid leukemia is not due to p110delta mutations. (16341041)
2006
32
Expression of B cell-specific activator protein/PAX5 in acute myeloid leukemia with t(8;21)(q22;q22). (16891199)
2006
33
Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemia. (15789228)
2005
34
Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome. (15902282)
2005
35
Characterization of CEBPA mutations in acute myeloid leukemia: most patients with CEBPA mutations have biallelic mutations and show a distinct immunophenotype of the leukemic cells. (15746035)
2005
36
Gefitinib induces myeloid differentiation of acute myeloid leukemia. (15998836)
2005
37
Delineation and molecular characterization of acute myeloid leukemia patients with coduplication of FLT3 and MLL. (16104873)
2005
38
The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. (15837624)
2005
39
Multidrug resistance markers monitoring in acute myeloid leukemia cells]. (15373290)
2004
40
Efficacy and toxicity of low-dose melphalan in myelodysplastic syndromes and acute myeloid leukemia with multilineage dysplasia. (12937849)
2003
41
New developments in antibody therapy for acute myeloid leukemia. (12939719)
2003
42
Quantitative real-time RT-PCR detects elevated Wilms tumor gene (WT1) expression in autologous blood stem cell preparations (PBSCs) from acute myeloid leukemia (AML) patients indicating contamination with leukemic blasts. (11919726)
2002
43
Activity and expression of the multidrug resistance proteins P-glycoprotein, MRP1, MRP2, MRP3 and MRP5 in de novo and relapsed acute myeloid leukemia. (11587212)
2001
44
HFE mutations do not account for transfusional iron overload in patients with acute myeloid leukemia. (11399828)
2001
45
A novel aminosteroid is active for proliferation inhibition and differentiation induction of human acute myeloid leukemia HL-60 cells. (10229323)
1999
46
Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. (10339474)
1999
47
CD117 (c-kit) is a restricted antigen of acute myeloid leukemia and characterizes early differentiative levels of M5 FAB subtype. (9658721)
1998
48
Possible association between adult T-cell leukemia/lymphoma and acute myeloid leukemia. (9452266)
1998
49
Blast cell proliferative activity and sensitivity to GM-CSF in vitro are associated with early response to TAD-9 induction therapy in acute myeloid leukemia. (7475275)
1995
50
Cytokines and cytokine receptors in acute lymphoblastic leukemia expressing myeloid markers--role in growth regulation. (7873998)
1994

Genetic Variations for Acute Myeloid Leukemia

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Acute Myeloid Leukemia:

63
id Symbol AA change Variation SNP ID
1JAK2p.Lys607AsnVAR_032696
2JAK2p.Val617PheVAR_032697
3SETBP1p.Gly870SerVAR_063809
4SETBP1p.Ser854AlaVAR_069848
5SETBP1p.Gly870ArgVAR_069854
6SETBP1p.Ile871SerVAR_069856

Expression for genes affiliated with Acute Myeloid Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia

Search GEO for disease gene expression data for Acute Myeloid Leukemia.

Pathways for genes affiliated with Acute Myeloid Leukemia

Sources:
30KEGG, 4Cell Signaling Technology, 38NCBI BioSystems Database
See all sources

Pathways related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3RUNX1, ARNT, FLT3, KIT, CEBPA
2
Hide members
11.1RUNX1, FLT3, KIT, CEBPA
311.1RUNX1, GATA2, KIT, CEBPA
411.1CEBPA, MLF1, FLT3, RUNX1
511.1KIT, FLT3, JAK2, NPM1
611.1TERT, ARNT, GATA2, NPM1

Compounds for genes affiliated with Acute Myeloid Leukemia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2413.3CEBPA, RUNX1, NPM1, JAK2, GATA2, ARNT
2oligonucleotide4512.2RUNX1, JAK2, GATA2, ARNT, ARHGEF12, FLT3
3tyrosine4512.0RUNX1, NPM1, JAK2, ARNT, ARHGEF12, FLT3
4leucine4511.8NPM1, JAK2, GATA2, PICALM, KIT, CEBPA
5vegf4511.7RUNX1, JAK2, ARNT, FLT3, KIT, TERT
6threonine4511.6RUNX1, NPM1, JAK2, FLT3, KIT, TERT
7rapamycin4511.6NPM1, JAK2, FLT3, KIT, TERT
8doxorubicin45 50 1113.6TERT, KIT, FLT3, NPM1, RUNX1
9imatinib45 50 1113.4RUNX1, JAK2, FLT3, KIT
10arsenite45 2412.4RUNX1, JAK2, FLT3, TERT
11butyrate4511.3RUNX1, JAK2, GATA2, TERT
12methylcellulose4511.2GATA2, FLT3, KIT
13leptomycin b45 6012.2NPM1, LPP, NUP214
14tandutinib4511.1KIT, FLT3
15beta-tyrosine4511.1JAK2, KIT
16lestaurtinib45 6012.1FLT3, JAK2
17hydroxyurea45 50 1113.0KIT, GATA2, JAK2
18gp 1304510.9JAK2, FLT3, KIT
19pkc 4124510.9KIT, FLT3
20su54164510.8KIT, FLT3
21ag-12964510.5KIT, FLT3

GO Terms for genes affiliated with Acute Myeloid Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.7WHSC1L1, NSD1, NPM1, JAK2, GATA2, ARNT

Biological processes related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922111.6JAK2, FLT3, NUP214, KIT, CEBPA
2myeloid progenitor cell differentiationGO:00231811.4KIT, MLF1, FLT3, RUNX1
3hemopoiesisGO:03009711.4RUNX1, PICALM, FLT3, KIT
4embryonic placenta developmentGO:00189211.2CEBPA, ARNT, GATA2
5positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.2KIT, FLT3, JAK2
6peptidyl-tyrosine phosphorylationGO:01810811.2JAK2, FLT3, KIT
7negative regulation of cell proliferationGO:00828511.0CEBPA, FLT3, JAK2, NPM1
8histone methylationGO:01657111.0WHSC1L1, NSD1
9definitive hemopoiesisGO:06021610.9GATA2, RUNX1
10positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9KIT, JAK2
11myeloid cell differentiationGO:03009910.8RUNX1, CEBPA
12positive regulation of erythrocyte differentiationGO:04564810.8ARNT, GATA2
13embryonic hemopoiesisGO:03516210.5KIT, RUNX1

Molecular functions related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.3WHSC1L1, RUNX1, NPM1, JAK2, GATA2, ARNT
2protein homodimerization activityGO:04280311.4RUNX1, NPM1, FLT3, KIT, TERT, CEBPA
3transcription factor bindingGO:00813410.8CEBPA, ARNT, GATA2, RUNX1
4phosphatidylinositol 3-kinase bindingGO:04354810.8FLT3, JAK2

Products for genes affiliated with Acute Myeloid Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Myeloid Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet