AML
MCID: ACT019
MIFTS: 94

Acute Myeloid Leukemia (AML) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Acute Myeloid Leukemia

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Leukemia is cancer of the white blood cells. white blood cells help your body fight infection. your blood cells form in your bone marrow. in leukemia, however, the bone marrow produces abnormal white blood cells. these cells crowd out the healthy blood cells, making it hard for blood to do its work. in acute myeloid leukemia (aml), there are too many of a specific type of white blood cell called a myeloblast. aml is the most common type of acute leukemia in adults. this type of cancer usually gets worse quickly if it is not treated. possible risk factors include smoking, previous chemotherapy treatment, and exposure to radiation. symptoms of aml include: fever shortness of breath easy bruising or bleeding bleeding under the skin weakness or feeling tired weight loss or loss of appetite tests that examine the blood and bone marrow diagnose aml. treatments include chemotherapy, other drugs, radiation therapy, stem cell transplants, and targeted therapy. targeted therapy uses substances that attack cancer cells without harming normal cells. once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute

MalaCards: Acute Myeloid Leukemia, also known as aml - acute myeloid leukemia, is related to leukemia and acute leukemia. An important gene associated with Acute Myeloid Leukemia is RUNX1 (runt-related transcription factor 1), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs cyclophosphamide and etoposide and the compounds retinoic acid and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are mortality/aging and cellular.

Wikipedia:63 Acute myeloid leukemia (AML), also known as acute myelogenous leukemia or acute nonlymphocytic leukemia... more...

Description from OMIM:46 602439,601626

Aliases & Classifications for Acute Myeloid Leukemia

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8Disease Ontology, 10DISEASES, 48Orphanet, 33MedlinePlus, 30LifeMap Discovery™, 22GTR, 60UMLS, 9diseasecard, 46OMIM, 42NIH Rare Diseases, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
acute myeloid leukemia:
Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

acute myeloid leukemia 8 10 48 33 30
aml - acute myeloid leukemia 8 22
leukemia, acute myeloblastic 9 46
leukemia, myelocytic, acute 8 60
aml 8 48
acute myeloid leukemia without mention of remission 8
acute non-lymphoblastic leukemia 48
acute myeloid leukaemia, disease 8
acute myeloblastic leukemia 8
acute myelogenous leukemia 48
acute myelocytic leukemia 42
acute myeloid leukaemia 8
leukemia, acute myeloid 46
anll in remission 8


External Ids:

Disease Ontology8 DOID:9119
MeSH34 D015470
ICD9CM27 205.0
MESH via Orphanet35 D015470
ICD10 via Orphanet26 C92.0
SNOMED-CT via Orphanet57 103691009, 17788007, 359648001 413443009, 91861009, more
UMLS via Orphanet61 C0023467, C1879321

Related Diseases for Acute Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
Myeloid Leukemia Acute Myeloid Leukemia, Adult
Npm1-Related Acute Myeloid Leukemia

Diseases related to Acute Myeloid Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 369)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.8ARNT, ARHGEF12, PICALM, FLT3, MLF1, SH3GL1
2acute leukemia32.7RUNX1, NPM1, JAK2, GATA2, FLT3, MLF1
3myeloid leukemia32.7RUNX1, NPM1, JAK2, GATA2, PICALM, FLT3
4myeloid sarcoma31.3KIT, FLT3
5sarcoma31.3RUNX1, JAK2, KIT, TERT
6chronic myeloid leukemia31.3RUNX1, JAK2, GATA2, FLT3, KIT
7acute lymphocytic leukemia31.1RUNX1, JAK2, GATA2, PICALM, FLT3, KIT
8breast cancer31.0RUNX1, NPM1, JAK2, GATA2, ARNT, FLT3
9systemic mastocytosis31.0JAK2, KIT
10myelofibrosis30.9KIT, JAK2
11down syndrome30.8RUNX1, JAK2, GATA2, FLT3
12aplastic anemia30.7TERT, FLT3, GATA2
13polycythemia30.7JAK2
14polycythemia vera30.6JAK2, FLT3, KIT
15thrombocytosis30.6FLT3, JAK2
16acute myeloid leukemia, adult30.5RUNX1, NPM1, FLT3, KIT
17acute promyelocytic leukemia30.5RUNX1, NPM1, GATA2, FLT3
18retinoblastoma30.4CEBPA, TERT, NPM1, RUNX1
19juvenile myelomonocytic leukemia30.4RUNX1, FLT3
20gastrointestinal stromal tumor30.4KIT, FLT3
21hepatocellular carcinoma29.7RUNX1, NPM1, TERT
22childhood leukemia11.0
23acute t cell leukemia11.0
24t-cell leukemia10.8
25acute monocytic leukemia10.8
26monocytic leukemia10.8
27lymphoblastic leukemia10.7
28neutropenia10.7
29familial acute myeloid leukemia with mutated cebpa10.7
30lymphoid leukemia10.7
31cytogenetically normal acute myeloid leukemia10.6
32diphtheria10.6
33mast-cell leukemia10.6
34aspergillosis10.6
35core binding factor acute myeloid leukemia10.6
36graft versus host disease10.6
37diabetes insipidus10.6
38invasive aspergillosis10.6
39mediastinitis10.6
40severe congenital neutropenia10.5
41natural killer cell leukemia10.5
42chronic lymphocytic leukemia10.5
43eosinophilia10.5
44acute myeloblastic leukemia without maturation10.5
45central nervous system leukemia10.5
46thrombocytopenia10.5
47hairy cell leukemia10.4
48multiple myeloma10.4
49myeloma10.4
50minimally differentiated acute myeloblastic leukemia10.4

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia:



Diseases related to acute myeloid leukemia

Clinical Features for Acute Myeloid Leukemia

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Sources:
46OMIM
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Clinical features from OMIM:

602439,601626

Clinical synopsis from OMIM:

601626

Drugs & Therapeutics for Acute Myeloid Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia

Search NIH Clinical Center for Acute Myeloid Leukemia

Search CenterWatch for Acute Myeloid Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Acute Myeloid Leukemia cell therapies at LifeMap Discovery.

Genetic Tests for Acute Myeloid Leukemia

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22GTR
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Genetic tests related to Acute Myeloid Leukemia:

id Genetic test Affiliating Genes
1 Aml - Acute Myeloid Leukemia22

Anatomical Context for Acute Myeloid Leukemia

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Acute Myeloid Leukemia:

32
Myeloid, Bone, Bone marrow, T cells, Testes, Skin, Monocytes, Endothelial, Breast, Nk cells, B cells, Lung, Testis, Liver, Brain, Kidney, Thyroid, Spleen, Pituitary, Smooth muscle, Eye, Colon, Pancreas, Tonsil, Small intestine

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Acute Myeloid Leukemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowCommon Myeloid Progenitor Cells Potential therapeutic candidate, affected by disease
2 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate

Animal Models for Acute Myeloid Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Myeloid Leukemia:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076813.2CEBPA, RUNX1, NSD1, NPM1, JAK2, GATA2
2MP:000538412.9RUNX1, NPM1, JAK2, GATA2, ARNT, ARHGEF12
3MP:000537812.6ARNT, GATA2, JAK2, NPM1, RUNX1, ARHGEF12
4MP:000539712.5RUNX1, NPM1, JAK2, GATA2, ARNT, ARHGEF12
5MP:000538712.2RUNX1, NPM1, JAK2, ARNT, ARHGEF12, PICALM
6MP:000200612.0RUNX1, NPM1, JAK2, ARNT, FLT3, KIT
7MP:000287311.7RUNX1, JAK2, GATA2, ARNT, SH3GL1, KIT
8MP:000537011.7RUNX1, NPM1, GATA2, ARNT, PICALM, KIT
9MP:000538911.6GATA2, ARNT, LPP, KIT, TERT, CEBPA
10MP:000537611.4RUNX1, GATA2, ARNT, PICALM, LPP, FLT3
11MP:000538010.8ARNT

Publications for Acute Myeloid Leukemia

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50PubMed
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Articles related to Acute Myeloid Leukemia:

(show top 50)    (show all 3054)
idTitleAuthorsYear
1
Bone marrow stromal cells in the pathogenesis of acute myeloid leukemia. (24389180)
2014
2
BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia. (24413067)
2014
3
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. (24014241)
2013
4
Lacrimal gland enlargement in acute myeloid leukemia. (23878498)
2013
5
Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia. (23135354)
2013
6
Recent advances in the management of therapy-related myelodysplastic syndromes and acute myeloid leukemia. (23343830)
2013
7
Whole exome sequencing in del(5q) myelodysplastic syndromes in transformation to acute myeloid leukemia. (24365791)
2013
8
CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia. (23744585)
2013
9
JmjC-domain containing histone demethylase 1B-mediated p15(Ink4b) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia. (22086844)
2013
10
Patterns of Infection in Patients With Myelodysplastic Syndromes and Acute Myeloid Leukemia Receiving Azacitidine as Salvage Therapy. Implications for Primary Antifungal Prophylaxis. (24220615)
2013
11
Dose-intense etoposide-cyclophosphamide without stem cell transplantation for patients with intermediate and high cytogenetic risk primary refractory and relapsed acute myeloid leukemia. (23759246)
2013
12
Mixed T/myeloid phenotype acute leukemia with rare variants of IDH1 and CEBPA. (23469962)
2013
13
T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia. (24030378)
2013
14
Role of neuropilin-1 and its expression in Egyptian acute myeloid and acute lymphoid leukemia patients. (21978468)
2012
15
Secondary acute myeloid leukemia occurring after successful treatment of acute promyelocytic leukemia. (22318353)
2012
16
A meta-analysis of TET2 mutations shows a distinct distribution pattern in de novo acute myeloid leukemia and chronic myelomonocytic leukemia. (22080757)
2012
17
U2AF1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. (23029227)
2012
18
Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen. (22529286)
2012
19
Identification of GLIPR1 tumor suppressor as methylation-silenced gene in acute myeloid leukemia by microarray analysis. (21922325)
2011
20
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation. (20795789)
2010
21
IDH mutations in glioma and acute myeloid leukemia. (20692206)
2010
22
Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients. (20061022)
2010
23
Amplification of the RARA gene in acute myeloid leukemia: significant finding or coincidental observation? (20804918)
2010
24
CD147 and VEGF co-expression predicts prognosis in patients with acute myeloid leukemia. (20558462)
2010
25
CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy. (19092854)
2009
26
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder. (19357396)
2009
27
Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia. (18451139)
2008
28
Prognostic significance of myeloperoxidase expression in childhood acute myeloid leukemia. (17763467)
2008
29
Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription. (17533375)
2007
30
Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma. (17377585)
2007
31
5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. (16043219)
2006
32
Critically short telomeres in acute myeloid leukemia with loss or gain of parts of chromosomes. (16281260)
2006
33
Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. (15840695)
2005
34
Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival. (15718307)
2005
35
Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia. (15994285)
2005
36
Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients. (15059064)
2004
37
PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22). (15188461)
2004
38
The detection of flow cytometric G-CSF receptor expression and it's effect on therapy in acute myeloid leukemia. (12802915)
2003
39
A pediatric case of lymphomatoid granulomatosis with onset after completion of chemotherapy for acute myeloid leukemia. (12571471)
2003
40
Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML. (11986951)
2002
41
The majority of children and adolescents with acute myeloid leukemia have detectable anti-DT388-GMCSF IgG concentrations, but at concentrations that should not preclude in vivo activity. (12368687)
2002
42
Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia. (11425459)
2001
43
Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia. (11549802)
2001
44
Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. (10995463)
2000
45
Secondary myeloid/natural killer cell precursor acute leukemia following essential thrombocythemia. (10414508)
1999
46
Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia. (9665198)
1998
47
Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. (8667638)
1996
48
TCR delta gene rearrangements in acute myeloid leukemia with T-lymphoid antigen expression. (8750622)
1995
49
c-fms point mutations in acute myeloid leukemia: fact or fiction? (8321048)
1993
50
In vitro growth response to G-CSF and GM-CSF by bone marrow cells of patients with acute myeloid leukemia. (1690827)
1990

Genetic Variations for Acute Myeloid Leukemia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute Myeloid Leukemia:

62
id Symbol AA change Variation ID SNP ID
1JAK2p.Lys607AsnVAR_032696
2JAK2p.Val617PheVAR_032697
3SETBP1p.Gly870SerVAR_063809
4SETBP1p.Ser854AlaVAR_069848
5SETBP1p.Gly870ArgVAR_069854
6SETBP1p.Ile871SerVAR_069856

Expression for genes affiliated with Acute Myeloid Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia

Search GEO for disease gene expression data for Acute Myeloid Leukemia.

Pathways for genes affiliated with Acute Myeloid Leukemia

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29KEGG, 4Cell Signaling Technology, 37NCBI BioSystems Database
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Pathways related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.3RUNX1, ARNT, FLT3, KIT, CEBPA
2
Hide members
11.1RUNX1, FLT3, KIT, CEBPA
311.1RUNX1, GATA2, KIT, CEBPA
411.1CEBPA, MLF1, FLT3, RUNX1
511.1KIT, FLT3, JAK2, NPM1
611.1TERT, ARNT, GATA2, NPM1

Compounds for genes affiliated with Acute Myeloid Leukemia

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.3CEBPA, RUNX1, NPM1, JAK2, GATA2, ARNT
2oligonucleotide4412.2RUNX1, JAK2, GATA2, ARNT, ARHGEF12, FLT3
3tyrosine4412.0RUNX1, NPM1, JAK2, ARNT, ARHGEF12, FLT3
4leucine4411.8NPM1, JAK2, GATA2, PICALM, KIT, CEBPA
5vegf4411.7RUNX1, JAK2, ARNT, FLT3, KIT, TERT
6threonine4411.6RUNX1, NPM1, JAK2, FLT3, KIT, TERT
7rapamycin4411.6NPM1, JAK2, FLT3, KIT, TERT
8doxorubicin44 49 1113.6TERT, KIT, FLT3, NPM1, RUNX1
9imatinib44 49 1113.4RUNX1, JAK2, FLT3, KIT
10arsenite44 2412.4RUNX1, JAK2, FLT3, TERT
11butyrate4411.3RUNX1, JAK2, GATA2, TERT
12methylcellulose4411.2GATA2, FLT3, KIT
13leptomycin b44 5912.2NPM1, LPP, NUP214
14tandutinib4411.1KIT, FLT3
15beta-tyrosine4411.1JAK2, KIT
16lestaurtinib44 5912.1FLT3, JAK2
17hydroxyurea44 49 1113.0KIT, GATA2, JAK2
18gp 1304410.9JAK2, FLT3, KIT
19pkc 4124410.9KIT, FLT3
20su54164410.8KIT, FLT3
21ag-12964410.5KIT, FLT3

GO Terms for genes affiliated with Acute Myeloid Leukemia

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16Gene Ontology
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Cellular components related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.7WHSC1L1, NSD1, NPM1, JAK2, GATA2, ARNT

Biological processes related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:01922111.6JAK2, FLT3, NUP214, KIT, CEBPA
2myeloid progenitor cell differentiationGO:00231811.4KIT, MLF1, FLT3, RUNX1
3hemopoiesisGO:03009711.4RUNX1, PICALM, FLT3, KIT
4embryonic placenta developmentGO:00189211.2CEBPA, ARNT, GATA2
5positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.2KIT, FLT3, JAK2
6peptidyl-tyrosine phosphorylationGO:01810811.2JAK2, FLT3, KIT
7negative regulation of cell proliferationGO:00828511.0CEBPA, FLT3, JAK2, NPM1
8histone methylationGO:01657111.0WHSC1L1, NSD1
9definitive hemopoiesisGO:06021610.9GATA2, RUNX1
10positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.9KIT, JAK2
11myeloid cell differentiationGO:03009910.8RUNX1, CEBPA
12positive regulation of erythrocyte differentiationGO:04564810.8ARNT, GATA2
13embryonic hemopoiesisGO:03516210.5KIT, RUNX1

Molecular functions related to Acute Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.3WHSC1L1, RUNX1, NPM1, JAK2, GATA2, ARNT
2protein homodimerization activityGO:04280311.4RUNX1, NPM1, FLT3, KIT, TERT, CEBPA
3transcription factor bindingGO:00813410.8CEBPA, ARNT, GATA2, RUNX1
4phosphatidylinositol 3-kinase bindingGO:04354810.8FLT3, JAK2

Products for genes affiliated with Acute Myeloid Leukemia

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  • Antibodies
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  • Antibodies

Sources for Acute Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet