MCID: ACT115
MIFTS: 36

Acute Myeloid Leukemia, Adult malady

Immune diseases category

Summaries for Acute Myeloid Leukemia, Adult

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46OMIM, 32MalaCards
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MalaCards: Acute Myeloid Leukemia, Adult, also known as acute myelogenous leukemia, is related to leukemia and acute leukemia. An important gene associated with Acute Myeloid Leukemia, Adult is ACSL6 (acyl-CoA synthetase long-chain family member 6), and among its related pathways are Hepatitis C and Adipocytokine signaling pathway. The compounds guanylate and butyrate have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotype tumorigenesis.

Description from OMIM:46 601626

Aliases & Classifications for Acute Myeloid Leukemia, Adult

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Sources:
42NIH Rare Diseases, 22GTR, 44Novoseek, 46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

acute myeloid leukemia, adult 42
acute myelogenous leukemia 42 22
aml adult 42 44
acute non-lymphocytic leukemia 42
adult acute myeloid leukemia 42
leukemia, acute myelogenous 46
acute granulocytic leukemia 42
myelogenous leukemia, acute 46


Related Diseases for Acute Myeloid Leukemia, Adult

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17GeneCards, 18GeneDecks
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Diseases in the Acute Myeloid Leukemia family:

Subacute Myeloid Leukemia Chronic Myeloid Leukemia
Myeloid Leukemia acute myeloid leukemia, adult
Npm1-Related Acute Myeloid Leukemia

Diseases related to Acute Myeloid Leukemia, Adult via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0KRAS, JAK2, IRF1
2acute leukemia30.5KRAS, JAK2, IRF1
3myeloid leukemia30.3IRF1, JAK2
4juvenile myelomonocytic leukemia30.2KRAS
5polycythemia vera30.2JAK2
6breast cancer30.1IRF1, JAK2, KRAS
7acute t cell leukemia10.7
8t-cell leukemia10.7
9acute lymphocytic leukemia10.6
10childhood leukemia10.6
11neutropenia10.5
12sarcoma10.5
13leukostasis10.4
14adult syndrome10.4
15lymphoblastic leukemia10.4
16graft versus host disease10.4
17severe congenital neutropenia10.4
18diabetes insipidus10.4
19hidradenitis10.4
20familial platelet disorder with associated myeloid malignancy10.4
21acute monocytic leukemia10.3
22pulmonary alveolar proteinosis10.3
23hemoglobinuria10.3
24mast-cell leukemia10.3
25aplastic anemia10.3
26aspergillosis10.3
27glossitis10.3
28monocytic leukemia10.3
29retinoblastoma10.3
30severe combined immunodeficiency10.3
31thrombocytopenia10.3
32familial platelet disorder with propensity to acute myelogenous leukemia10.3
33megakaryocytic leukemia10.2
34acute myeloid leukemia10.2
35central nervous system leukemia10.2
36vascular disease10.2
37lymphoid leukemia10.1
38acute thyroiditis10.1
39suppurative thyroiditis10.1
40neurofibromatosis10.1
41marantic endocarditis10.1
42acute interstitial pneumonia10.1
43diamond-blackfan anemia10.1
44bloom syndrome10.1
45conversion disorder10.1
46klinefelter's syndrome10.1
47hemophagocytic lymphohistiocytosis10.1
48pseudotumor cerebri10.1
49diphtheria10.1
50erysipelas10.1

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia, Adult:



Diseases related to acute myeloid leukemia, adult

Clinical Features for Acute Myeloid Leukemia, Adult

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46OMIM
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Clinical features from OMIM:

601626

Drugs & Therapeutics for Acute Myeloid Leukemia, Adult

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Myeloid Leukemia, Adult

Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia, Adult

Search NIH Clinical Center for Acute Myeloid Leukemia, Adult

Search CenterWatch for Acute Myeloid Leukemia, Adult

Genetic Tests for Acute Myeloid Leukemia, Adult

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22GTR
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Genetic tests related to Acute Myeloid Leukemia, Adult:

id Genetic test Affiliating Genes
1 Acute Myelogenous Leukemia22

Anatomical Context for Acute Myeloid Leukemia, Adult

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32MalaCards
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MalaCards organs/tissues related to Acute Myeloid Leukemia, Adult:

32
Myeloid

Animal Models for Acute Myeloid Leukemia, Adult or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Myeloid Leukemia, Adult:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6KRAS, JAK2, IRF1

Publications for Acute Myeloid Leukemia, Adult

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Genetic Variations for Acute Myeloid Leukemia, Adult

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute Myeloid Leukemia, Adult:

62
id Symbol AA change Variation ID SNP ID
1JAK2p.Lys607AsnVAR_032696
2JAK2p.Val617PheVAR_032697
3SETBP1p.Gly870SerVAR_063809
4SETBP1p.Ser854AlaVAR_069848
5SETBP1p.Gly870ArgVAR_069854
6SETBP1p.Ile871SerVAR_069856

Expression for genes affiliated with Acute Myeloid Leukemia, Adult

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia, Adult

Search GEO for disease gene expression data for Acute Myeloid Leukemia, Adult.

Pathways for genes affiliated with Acute Myeloid Leukemia, Adult

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN, 52R&D Systems
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Pathways related to Acute Myeloid Leukemia, Adult according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4KRAS, IRF1
29.2ACSL6, JAK2
39.1JAK2, KRAS
49.1KRAS, JAK2
5
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.1JAK2, KRAS
6
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9.1KRAS, JAK2
79.1KRAS, JAK2
89.1JAK2, IRF1
9
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9.1IRF1, JAK2
10
Immune response IFN gamma signaling pathway
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9.1JAK2, IRF1
119.1JAK2, IRF1
129.1JAK2, IRF1
139.1JAK2, IRF1
14
Immune response Bacterial infections in normal airways
9.1JAK2, IRF1
15
Hide members
8.6IRF1, JAK2, KRAS
16
Hide members
8.6KRAS, JAK2, IRF1
17
Development Prolactin receptor signaling
Hide members
8.6KRAS, JAK2, IRF1

Compounds for genes affiliated with Acute Myeloid Leukemia, Adult

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Sources:
44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Acute Myeloid Leukemia, Adult according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1guanylate449.2IRF1, GMPS
2butyrate448.7KRAS, JAK2, IRF1
3oligonucleotide448.6KRAS, JAK2, IRF1
4Adenosine triphosphate11 249.6ACSL6, GMPS, JAK2
5phosphatidylinositol448.3KRAS, JAK2, IRF1

GO Terms for genes affiliated with Acute Myeloid Leukemia, Adult

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16Gene Ontology
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Cellular components related to Acute Myeloid Leukemia, Adult according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.1KRAS, JAK2

Biological processes related to Acute Myeloid Leukemia, Adult according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:0001869.1KRAS, JAK2
2negative regulation of neuron apoptotic processGO:0435249.1KRAS, JAK2
3interferon-gamma-mediated signaling pathwayGO:0603338.8JAK2, IRF1
4cytokine-mediated signaling pathwayGO:0192218.7KRAS, JAK2, IRF1
5blood coagulationGO:0075968.5IRF1, JAK2, KRAS

Products for genes affiliated with Acute Myeloid Leukemia, Adult

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Myeloid Leukemia, Adult

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet