MCID: ACT115
MIFTS: 27

Acute Myeloid Leukemia, Adult malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Cancer diseases categories

Aliases & Classifications for Acute Myeloid Leukemia, Adult

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Sources:
42NIH Rare Diseases, 44Novoseek, 22GTR, 61UMLS
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Aliases & Descriptions for Acute Myeloid Leukemia, Adult:

Name: Acute Myeloid Leukemia, Adult 42
Leukemia Acute Myelogenous 42 22
Aml Adult 42 44
Adult Acute Myeloid Leukemia Without Maturation 61
Adult Acute Myeloblastic Leukemia 61
Acute Non-Lymphocytic Leukemia 42
 
Adult Acute Myeloid Leukemia 42
Leukemia, Myelocytic, Acute 61
Acute Granulocytic Leukemia 42
Acute Myelogenous Leukemia 42
Acute Myeloid Leukemia 42
Aml 42


Classifications:



Summaries for Acute Myeloid Leukemia, Adult

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MalaCards based summary: Acute Myeloid Leukemia, Adult, also known as leukemia acute myelogenous, is related to core binding factor acute myeloid leukemia and myelodysplastic syndrome. An important gene associated with Acute Myeloid Leukemia, Adult is GATA2 (GATA binding protein 2). The drugs cyclophosphamide and etoposide have been mentioned in the context of this disorder. Affiliated tissues include myeloid.

Related Diseases for Acute Myeloid Leukemia, Adult

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Diseases in the Myeloid Leukemia family:

Leukemia, Acute Myeloid Leukemia, Chronic Myeloid
Subacute Myeloid Leukemia acute myeloid leukemia, adult
Npm1-Related Acute Myeloid Leukemia Inherited Acute Myeloid Leukemia
'acute Myeloid Leukemia with T(9;11)(p22;q23)' 'acute Myeloid Leukemia with T(6;9)(p23;q34)'

Diseases related to Acute Myeloid Leukemia, Adult via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 337)
idRelated DiseaseScoreTop Affiliating Genes
1core binding factor acute myeloid leukemia11.0
2myelodysplastic syndrome10.9
3leukemia10.7
4familial acute myeloid leukemia with mutated cebpa10.7
5acute myeloid leukemia with multilineage dysplasia10.7
6myelofibrosis10.7
7hematopoietic stem cell transplantation10.6
8mediastinitis10.6
9sarcoma10.6
10essential thrombocythemia10.6
11neutropenia10.5
12leukostasis10.5
13leukemia, acute promyelocytic10.5
14chronic lymphocytic leukemia10.5
15'acute myeloid leukemia with t(9;11)(p22;q23)'10.5
16leukemia, acute myeloid10.5
17platelet disorder, familial, with associated myeloid malignancy10.5
18familial platelet disorder with propensity to acute myelogenous leukemia10.5
19central nervous system disease10.5
20nervous system disease10.5
21blastic plasmacytoid dendritic cell10.5
22blindness10.5
23inherited acute myeloid leukemia10.5
24acute myeloid leukemia with t(8;16)(p11;p13) translocation10.5
25'acute myeloid leukemia with t(6;9)(p23;q34)'10.5
26acute myeloid leukemia with 11q23 abnormalities10.5
27severe congenital neutropenia10.4
28diabetes insipidus10.4
29hidradenitis10.4
30lymphoblastic leukemia10.4
31acute febrile neutrophilic dermatosis10.4
32mastocytosis10.4
33zygomycosis10.4
34endotheliitis10.4
35refractory anemia10.4
36acute erythroid leukemia10.4
37sinusitis10.4
38mast-cell leukemia10.4
39obstructive jaundice10.4
40thrombophlebitis10.4
41uveitis10.4
42acute myeloid leukemia, childhood10.4
43acute myeloid leukemia, susceptibility, gata2-related10.4
44npm1-related acute myeloid leukemia10.4
45hypoxia10.4
46acute myeloid leukemia and myelodysplastic syndromes related to radiation10.4
47acute myeloid leukemia with cebpa somatic mutations10.4
48'acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)'10.4
49'megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)'10.4
50acute myeloid leukemia with npm1 somatic mutations10.4

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia, Adult:



Diseases related to acute myeloid leukemia, adult

Symptoms for Acute Myeloid Leukemia, Adult

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Drugs & Therapeutics for Acute Myeloid Leukemia, Adult

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Mylotarg13 38 GEMTUZUMAB OZOGAMICIN Wyeth Approved May 2000
FDA Label: Mylotarg
Malady that Drug Treats: Acute Myeloid Leukemia (AML)
Indications and Usage:13 Mylotarg is indicated for the treatment of patients with CD33 positive acute myeloid leukemia in; first relapse who are 60 years of age or older and who are not considered candidates for other; cytotoxic chemotherapy. The safety and efficacy of Mylotarg in patients with poor performance; status and organ dysfunction has not been established.; The effectiveness of Mylotarg is based on OR rates (see CLINICAL STUDIES section). There; are no controlled trials demonstrating a clinical benefit, such as improvement in disease-related; symptoms or increased survival, compared to any other treatment.
DrugBank Targets:11 1. Myeloid cell surface antigen CD33; 2. Low affinity immunoglobulin gamma Fc region receptor III-B; 3. Complement C1r subcomponent; 4. Complement C1q subcomponent subunit A; 5. Complement C1q subcomponent subunit B; 6. Complement C1q subcomponent subunit C; 7. Low affinity immunoglobulin gamma Fc region receptor III-A; 8. Complement C1s subcomponent; 9. High affinity immunoglobulin gamma Fc receptor I; 10. Low affinity immunoglobulin gamma Fc region receptor II-a; 11. Low affinity immunoglobulin gamma Fc region receptor II-b; 12. Low affinity immunoglobulin gamma Fc region receptor II-c
Mechanism of Action:13 
Target: CD33 antigen expressed by; hematopoietic cells
Action: binds to form complex that then causes a break in the DNA double strand
FDA: Mylotarg is directed against the CD33 antigen expressed by; hematopoietic cells. Binding of the anti-CD33 antibody portion of Mylotarg with the CD33; antigen results in the formation of a complex that is internalized. Upon internalization, the; calicheamicin derivative is released inside the lysosomes of the myeloid cell. The released; calicheamicin derivative binds to DNA in the minor groove resulting in DNA double strand; breaks and cell death.; Gemtuzumab ozogamicin is cytotoxic to the CD33 positive HL-60 human leukemia cell line.; Gemtuzumab ozogamicin produces significant inhibition of colony formation in cultures of adult; leukemic bone marrow cells. The cytotoxic effect on normal myeloid precursors leads to; substantial myelosuppression, but this is reversible because pluripotent hematopoietic stem cells; are spared. In preclinical animal studies, gemtuzumab ozogamicin demonstrates antitumor; effects in the HL-60 human promyelocytic leukemia xenograft tumor in athymic mice.

Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia, Adult

Search NIH Clinical Center for Acute Myeloid Leukemia, Adult

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Acute Myeloid Leukemia, Adult

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Genetic tests related to Acute Myeloid Leukemia, Adult:

id Genetic test Affiliating Genes
1 Acute Myelogenous Leukemia22

Anatomical Context for Acute Myeloid Leukemia, Adult

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MalaCards organs/tissues related to Acute Myeloid Leukemia, Adult:

31
Myeloid

Animal Models for Acute Myeloid Leukemia, Adult or affiliated genes

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Publications for Acute Myeloid Leukemia, Adult

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Variations for Acute Myeloid Leukemia, Adult

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Clinvar genetic disease variations for Acute Myeloid Leukemia, Adult:

5
id Gene Variation Type Significance SNP ID Assembly Location
1GATA2NM_001145661.1(GATA2): c.1061C> T (p.Thr354Met)single nucleotide variantPathogenic, risk factorrs387906631GRCh37Chr 3, 128200744: 128200744

Expression for genes affiliated with Acute Myeloid Leukemia, Adult

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Search GEO for disease gene expression data for Acute Myeloid Leukemia, Adult.

Pathways for genes affiliated with Acute Myeloid Leukemia, Adult

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Compounds for genes affiliated with Acute Myeloid Leukemia, Adult

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GO Terms for genes affiliated with Acute Myeloid Leukemia, Adult

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Sources for Acute Myeloid Leukemia, Adult

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet