MCID: ACT115
MIFTS: 49

Acute Myeloid Leukemia, Adult malady

Immune category

Summaries for Acute Myeloid Leukemia, Adult

Sources:
47OMIM, 33MalaCards
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MalaCards: Acute Myeloid Leukemia, Adult, also known as acute myelogenous leukemia, is related to myelodysplastic syndromes and severe congenital neutropenia. An important gene associated with Acute Myeloid Leukemia, Adult is ACSL6 (acyl-CoA synthetase long-chain family member 6), and among its related pathways are IL-3 Signaling Pathway and Thyroid cancer. The compounds tamoxifen and o6-methylguanine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lung and breast, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Description from OMIM:47 601626

Aliases & Classifications for Acute Myeloid Leukemia, Adult

Sources:
43NIH Rare Diseases, 22GTR, 47OMIM, 45Novoseek
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

acute myeloid leukemia, adult 43
acute myelogenous leukemia 43 22
aml adult 43 45
acute non-lymphocytic leukemia 43
adult acute myeloid leukemia 43
leukemia, acute myelogenous 47
acute granulocytic leukemia 43
myelogenous leukemia, acute 47


Related Diseases for Acute Myeloid Leukemia, Adult

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Myeloid Leukemia, Adult via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1myelodysplastic syndromes30.8IL3, JAK2, IRF1, KRAS
2severe congenital neutropenia30.5JAK2, IL3
3refractory anemia30.5IL3, JAK2
4acute lymphocytic leukemia30.5JAK2, IL3, KRAS
5acute leukemia30.5IRF1, JAK2, IL3, KRAS
6juvenile myelomonocytic leukemia30.2KRAS
7polycythemia vera30.2IL3, JAK2
8acute t cell leukemia11.0
9t-cell leukemia11.0
10n syndrome10.6
11hematopoietic stem cell transplantation10.6
12adult t-cell leukemia10.5
13leukostasis10.5
14adult syndrome10.5
15graft versus host disease10.4
16diabetes insipidus10.4
17acute febrile neutrophilic dermatosis10.4
18acute graft versus host disease10.4
19acute myelomonocytic leukemia10.4
20acute promyelocytic leukemia10.4
21familial platelet disorder with associated myeloid malignancy10.4
22mastocytosis10.4
23acute monocytic leukemia10.3
24pulmonary alveolar proteinosis10.3
25hemoglobinuria10.3
26mast-cell leukemia10.3
27aplastic anemia10.3
28aspergillosis10.3
29thrombocytopenia10.3
30acute biphenotypic leukemia10.3
31bone marrow necrosis10.3
32granulocytopenia10.3
33paroxysmal nocturnal hemoglobinuria10.3
34tetraploidy10.3
35zygomycosis10.3
36familial platelet disorder with propensity to acute myelogenous leukemia10.3
37myeloproliferative disorder10.3
38leukemia, post-chemotherapy10.3
39acute myeloid leukemia10.2
40central nervous system leukemia10.2
41myeloid sarcoma10.2
42vascular disease10.2
43hypoxia10.2
44venous thrombosis10.2
45lymphoid leukemia10.2
46acute thyroiditis10.2
47suppurative thyroiditis10.2
48neurofibromatosis10.2
49marantic endocarditis10.2
50acute interstitial pneumonia10.2

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia, Adult:



Diseases related to acute myeloid leukemia, adult

Clinical Features for Acute Myeloid Leukemia, Adult

Sources:
47OMIM
See all sources

Clinical features from OMIM:

601626

Drugs & Therapeutics for Acute Myeloid Leukemia, Adult

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Myeloid Leukemia, Adult

Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia, Adult

Search NIH Clinical Center for Acute Myeloid Leukemia, Adult

Search CenterWatch for Acute Myeloid Leukemia, Adult

Genetic Tests for Acute Myeloid Leukemia, Adult

Sources:
22GTR
See all sources

Genetic tests related to Acute Myeloid Leukemia, Adult:

id Genetic test Affiliating Genes
1 Acute Myelogenous Leukemia22

Anatomical Context for Acute Myeloid Leukemia, Adult

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Myeloid Leukemia, Adult:

33
Bone marrow, Lung, Breast, Myeloid, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Acute Myeloid Leukemia, Adult or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Myeloid Leukemia, Adult:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.6IRF1
2MP:00020069.4KRAS, IRF1
3MP:00053877.6TP53, KRAS, IL3, JAK2, IRF1
4MP:00053977.5IRF1, JAK2, IL3, KRAS, TP53

Publications for Acute Myeloid Leukemia, Adult

Sources:
51PubMed
See all sources

Articles related to Acute Myeloid Leukemia, Adult:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
FLT3-ITD and MLL-PTD influence the expression of MDR-1, MRP-1, and BCRP mRNA but not LRP mRNA assessed with RQ-PCR method in adult acute myeloid leukemia. (24030729)
2013
2
Prevalence of extramedullary relapses is higher after allogeneic stem cell transplantation than after chemotherapy in adult patients with acute myeloid leukemia. (24054717)
2013
3
Risk assessment before allogeneic hematopoietic cell transplantation for older adults with acute myeloid leukemia. (24083472)
2013
4
Rapid detection of AML1 associated fusion genes in patients with adult acute myeloid leukemia and its clinical significance. (23998567)
2013
5
Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. (23677058)
2013
6
Expert insights into the contemporary management of older adults with acute myeloid leukemia. (24077448)
2013
7
Biological and clinical features of trisomy 21 in adult patients with acute myeloid leukemia. (23969309)
2013
8
Clinical importance of myeloid antigen expression in Moroccan patients with adult B-lineage acute lymphoblastic leukemia. (23790175)
2013
9
Characteristics and Prognosis of Adult Acute Myeloid Leukemia with Internal Tandem Duplication in the FLT3 Gene. (24223248)
2013
10
Low 25(OH) vitamin D3 levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia. (24166051)
2013
11
Preclinical and phase i results of decitabine in combination with midostaurin (PKC412) for newly diagnosed elderly or relapsed/refractory adult patients with acute myeloid leukemia. (23798029)
2013
12
Phase I study of azacitidine and bortezomib in adults with relapsed or refractory acute myeloid leukemia. (23952243)
2013
13
The prognostic significance of IRF8 transcripts in adult patients with acute myeloid leukemia. (23967110)
2013
14
Neurofibromatosis-1 gene deletions and mutations in de novo adult acute myeloid leukemia. (23460398)
2013
15
Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. (21685467)
2011
16
High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9-positive patients. (21937695)
2011
17
PHF6 mutations in adult acute myeloid leukemia. (21030981)
2011
18
Hypoxia-inducible factor-1I+ protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia. (21176961)
2011
19
A population-based study of the epidemiology and clinical features of adults with acute myeloid leukemia in Algeria: report on behalf of the Algerian Acute Leukemia Study Group. (22198187)
2011
20
The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia. (21079611)
2011
21
Prognostic potential of detection of WT1 mRNA level in peripheral blood in adult acute myeloid leukemia. (20849384)
2010
22
High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia. (20522712)
2010
23
High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities. (20308656)
2010
24
Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. (20097881)
2010
25
The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia. (19151774)
2009
26
AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. (19808697)
2009
27
Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics. (19396856)
2009
28
FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications. (17940205)
2008
29
Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. (18591546)
2008
30
Effect of priming with granulocyte-macrophage colony-stimulating factor in younger adults with newly diagnosed acute myeloid leukemia: a trial by the Acute Leukemia French Association (ALFA) Group. (17252021)
2007
31
Glutathione S-transferase GSTM1 and GSTT1 polymorphisms in adult acute myeloid leukemia; its impact on toxicity and response to chemotherapy. (17671537)
2006
32
Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia. (16573741)
2006
33
The frequencies of NAD(P)H quinone oxidoreductase (NQO1) variant allele in Israeli ethnic groups and the relationship of NQO1*2 to adult acute myeloid leukemia in Israeli patients. (16818284)
2006
34
An antecedent diagnosis of refractory anemia with excess blasts has no prognostic relevance in acute myeloid leukemia of older adult patients. (16687417)
2006
35
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. (16051734)
2005
36
MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia. (16278398)
2005
37
Acute myeloid leukemia in an adult Noonan syndrome patient with PTPN11 mutation. (15929108)
2005
38
Breast cancer resistance protein and P-glycoprotein in 149 adult acute myeloid leukemias. (15585622)
2004
39
KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication. (15339674)
2004
40
A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group. (14512295)
2004
41
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. (14726504)
2004
42
Two patients with nonimmune chronic idiopathic neutropenia of adults developing acute myeloid leukemia with aberrant phenotype and complex karyotype but no mutations in granulocyte colony-stimulating factor receptor. (11807637)
2002
43
Soluble hepatocyte growth factor (sHGF) and vascular endothelial growth factor (sVEGF) in adult acute myeloid leukemia: relationship to disease characteristics. (12850814)
2002
44
JC-1: a very sensitive fluorescent probe to test Pgp activity in adult acute myeloid leukemia. (11154229)
2001
45
Acute myeloid leukemia in adults: where do we go from here? (11587367)
2001
46
The prognostic value of Bcl-XL gene expression for remission induction is influenced by cytogenetics in adult acute myeloid leukemia. (11410409)
2001
47
The immunophenotype of 177 adults with acute myeloid leukemia: proposal of a prognostic score. (10910899)
2000
48
Trisomy 10 in acute myeloid leukemia. Three additional cases from the database of the Japan Adult Leukemia Study Group (JALSG) AML-92 and AML-95. (10942805)
2000
49
Lung resistance protein (LRP) gene expression in adult acute myeloid leukemia: a critical evaluation by three techniques. (9737684)
1998
50
Molecular rearrangement of the MLL gene in adult acute myeloid leukemia without cytogenetic evidence of 11q23 aberration. (8616778)
1996

Genetic Variations for Acute Myeloid Leukemia, Adult

Expression for genes affiliated with Acute Myeloid Leukemia, Adult

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia, Adult

Search GEO for disease gene expression data for Acute Myeloid Leukemia, Adult.

Pathways for genes affiliated with Acute Myeloid Leukemia, Adult

Sources:
38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 53R&D Systems, 54Reactome, 52QIAGEN
See all sources

Pathways related to Acute Myeloid Leukemia, Adult according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL3
29.5TP53, KRAS
39.3JAK2, IRF1
49.3IRF1, JAK2
59.3JAK2, IRF1
6
Immune response Bacterial infections in normal airways
9.3JAK2, IRF1
7
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.0TP53, KRAS, JAK2
8
Hide members
8.9KRAS, JAK2, IRF1
9
Development Prolactin receptor signaling
Hide members
8.9IRF1, JAK2, KRAS
108.9IRF1, KRAS, TP53
118.8TP53, JAK2, IRF1
12
Hide members
8.8IRF1, JAK2, TP53
13
Hide members
8.7KRAS, IL3, JAK2
148.7IL3, KRAS, TP53
158.5TP53, IRF1, IL3
168.2JAK2, IL3, KRAS, TP53
17
Hide members
8.1KRAS, IL3, JAK2, IRF1

Compounds for genes affiliated with Acute Myeloid Leukemia, Adult

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 24HMDB
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Compounds related to Acute Myeloid Leukemia, Adult according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1tamoxifen45 50 29 1113.1IRF1
2o6-methylguanine459.8KRAS, TP53
3crcs459.7KRAS, TP53
4parthenolide45 210.6TP53, JAK2
5oxaliplatin45 50 1111.5TP53, KRAS
6lomustine45 1110.5TP53, IL3
7amifostine45 1110.5IL3, TP53
8leucovorin45 50 1111.2KRAS, IL3
9suberoylanilide hydroxamic acid459.2IRF1, TP53
10depsipeptide459.2TP53, IL3
11imatinib45 50 1111.1KRAS, IL3, JAK2
12sb 20358045 6010.1IRF1, JAK2, TP53
13valine459.1JAK2, IL3, KRAS
145fluorouracil459.0TP53, KRAS, IL3
15hydroxyurea45 50 1111.0TP53, IL3, JAK2
165-aza-2deoxycytidine459.0TP53, IL3, JAK2
17paclitaxel45 50 1110.9TP53, KRAS, IL3
18adriamycin458.9IRF1, IL3, TP53
19n acetylcysteine458.9TP53, IL3, JAK2
20rapamycin458.9KRAS, IL3, JAK2
21wortmannin458.8JAK2, IL3, KRAS
22etoposide45 50 60 1111.8TP53, IL3, IRF1
23poly(i-c)458.7IL3, IRF1
24oligonucleotide458.7TP53, KRAS, JAK2, IRF1
25ly294002458.6JAK2, IL3, KRAS, TP53
26cisplatin45 50 60 1111.6JAK2, IL3, KRAS, TP53
27h2o2458.6JAK2, IL3, KRAS, TP53
28phosphatidylinositol458.4IRF1, JAK2, IL3, KRAS
29actinomycin d458.4TP53, IL3, JAK2, IRF1
30thymidine45 249.4IRF1, JAK2, IL3, TP53
31cycloheximide458.4TP53, IL3, JAK2, IRF1
32butyrate458.0TP53, KRAS, IL3, JAK2, IRF1
33retinoic acid45 249.0IRF1, JAK2, IL3, KRAS, TP53
34serine457.9IRF1, JAK2, IL3, KRAS, TP53

GO Terms for genes affiliated with Acute Myeloid Leukemia, Adult

Sources:
16Gene Ontology
See all sources

Biological processes related to Acute Myeloid Leukemia, Adult according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:0001869.5KRAS, JAK2
2response to antibioticGO:0466779.5JAK2, TP53
3interferon-gamma-mediated signaling pathwayGO:0603339.3JAK2, IRF1
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.3IL3, JAK2
5cytokine-mediated signaling pathwayGO:0192219.0KRAS, JAK2, IRF1
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8TP53, IL3, JAK2
7negative regulation of cell proliferationGO:0082858.7IRF1, JAK2, TP53
8blood coagulationGO:0075968.6IRF1, JAK2, KRAS, TP53
9positive regulation of cell proliferationGO:0082848.4KRAS, IL3, JAK2

Products for genes affiliated with Acute Myeloid Leukemia, Adult

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Sources for Acute Myeloid Leukemia, Adult

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet