MCID: ACT193
MIFTS: 53

Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22)

Categories: Rare diseases, Cancer diseases, Immune diseases, Bone diseases, Blood diseases

Aliases & Classifications for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

MalaCards integrated aliases for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

Name: Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) 49 55
Acute Myelomonocytic Leukemia 49 55 28 69
Aml with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) 49 55
Aml M4 49 55
Ammol 49 55
Aml with Inv(16)(p13.1q22) or T(16;16)(p13.1;q22) 49
Acute Myeloblastic Leukemia Type 4 49
Leukemia, Acute Myelomonocytic 13
Leukemia Myelomonocytic Acute 51
Cbfb-Myh11 49
Aml-M4 49

Characteristics:

Orphanet epidemiological data:

55
acute myelomonocytic leukemia
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

MESH via Orphanet 42 D015479
UMLS via Orphanet 70 C0023479
ICD10 via Orphanet 33 C92.5
ICD10 32 C92.5
UMLS 69 C0023479

Summaries for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

NIH Rare Diseases : 49 Acute myelomonocytic leukemia (AMML) is a cancer that typically develops in the bone marrow and blood of older individuals.  AMML is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly.  Symptoms of AMML often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia).  The cause of AMML is currently unknown.  Treatment typically consists of chemotherapy. Last updated: 2/12/2013

MalaCards based summary : Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22), also known as acute myelomonocytic leukemia, is related to ring chromosome 21 and leukemia, and has symptoms including fever and fatigue. An important gene associated with Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) is CBFB (Core-Binding Factor Beta Subunit), and among its related pathways/superpathways are PAK Pathway and Endometrial cancer. Affiliated tissues include bone marrow, bone and myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 ring chromosome 21 30.0 ETV6 KMT2A
2 leukemia 29.6 CBFB CREBBP ETV6 FLT3 KIT KMT2A
3 leukemia, acute monocytic 29.4 CREBBP KMT2A MPO
4 chronic myelomonocytic leukemia 29.4 ETV6 FLT3 KIT RUNX1
5 lymphoblastic leukemia 29.4 ETV6 FLT3 RUNX1
6 acute promyelocytic leukemia 29.3 CSF1R FLT3 MPO RUNX1
7 aleukemic leukemia cutis 29.3 FLT3 MPO MYH11 RUNX1
8 myeloid sarcoma 29.1 DNTT FLT3 KIT KMT2A MPO
9 leukemia, chronic myeloid 28.8 DNTT ETV6 FLT3 KIT RUNX1
10 malignant histiocytosis 28.8 CSF1 CSF1R
11 myeloid leukemia 27.7 CBFB CREBBP ETV6 FLT3 KIT MPO
12 myelodysplastic syndrome 27.3 CSF1 CSF1R DNTT ETV6 FLT3 KIT
13 acute leukemia 27.1 CREBBP DNTT ETV6 FLT3 KIT KMT2A
14 acute myeloblastic leukemia with maturation 10.4 FLT3 KIT
15 acute myeloid leukemia with minimal differentiation 10.4 FLT3 MPO
16 cytogenetically normal acute myeloid leukemia 10.3 FLT3 KMT2A
17 lymphoplasmacytic lymphoma 10.3 CBFB MYH11
18 mast-cell sarcoma 10.3 KIT MPO
19 chronic eosinophilic leukemia 10.3 FLT3 KIT
20 uterine inversion 10.3 CSF1R KIT
21 sarcoma 10.3
22 mn1 10.2 ETV6 FLT3
23 polymorphous low-grade adenocarcinoma 10.2 KIT MYH11
24 acute basophilic leukemia 10.2 ETV6 MPO
25 congenital mesoblastic nephroma 10.1 ETV6 KIT
26 platelet disorder, familial, with associated myeloid malignancy 10.1 ETV6 RUNX1
27 neonatal leukemia 10.1 CREBBP FLT3
28 myeloma, multiple 10.1
29 tetrasomy 21 10.1 DNTT RUNX1
30 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.0 FLT3 KIT RUNX1
31 lymphoma 10.0
32 myelofibrosis 10.0 FLT3 KIT MPO
33 dendritic cell tumor 10.0 DNTT MPO
34 8p11 myeloproliferative syndrome 10.0 FLT3 KIT RUNX1
35 mycosis fungoides 10.0
36 gingivitis 10.0
37 acute biphenotypic leukemia 10.0 DNTT KMT2A MPO
38 lymphoblastic lymphoma 9.9 DNTT KMT2A MPO
39 malignant mesenchymoma 9.9 ETV6 KIT
40 multiple cranial nerve palsy 9.9 MPO RUNX1
41 acute lymphoblastic leukemia, childhood 9.9 ETV6 FLT3 RUNX1
42 tenosynovial giant cell tumor 9.9 CSF1 CSF1R
43 lymphoid leukemia 9.9 ETV6 KMT2A RUNX1
44 leukemia, chronic lymphocytic 2 9.9
45 leukemia, chronic lymphocytic 9.9
46 vasculitis 9.9
47 macroglobulinemia 9.9
48 leukemia, b-cell, chronic 9.9
49 pdgfrb-associated chronic eosinophilic leukemia 9.9
50 xp22.13p22.2 duplication syndrome 9.9

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):



Diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22)

Symptoms & Phenotypes for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

UMLS symptoms related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):


fever, fatigue

GenomeRNAi Phenotypes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

25 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.06 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.06 FLT3 KIT DNTT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.06 FLT3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.06 FLT3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.06 FLT3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.06 FLT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.06 DNTT FLT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.06 MPO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.06 DNTT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.06 DNTT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.06 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.06 DNTT KIT MPO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.06 DNTT
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.06 FLT3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.06 KIT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.06 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-182 10.06 DNTT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.06 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.06 DNTT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.06 FLT3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.06 MPO
22 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.06 KIT
23 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.06 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.06 KIT
25 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.06 MPO
26 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.06 MPO
27 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.06 MPO FLT3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.06 DNTT
29 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.06 KIT
30 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.06 KIT
31 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.06 KIT

MGI Mouse Phenotypes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

43 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.29 KIT DNTT ETV6 FLT3 CBFB CSF1
2 cardiovascular system MP:0005385 10.28 KIT DNTT ETV6 CBFB CSF1 CREBBP
3 cellular MP:0005384 10.27 FLT3 KIT ETV6 CSF1R CBFB CSF1
4 hematopoietic system MP:0005397 10.26 KIT DNTT ETV6 FLT3 CBFB CSF1
5 growth/size/body region MP:0005378 10.24 CSF1R FLT3 KIT ETV6 CREBBP CBFB
6 immune system MP:0005387 10.24 KIT DNTT ETV6 FLT3 CSF1R CBFB
7 endocrine/exocrine gland MP:0005379 10.15 CSF1R FLT3 KIT ETV6 CREBBP CBFB
8 mortality/aging MP:0010768 10.14 FLT3 KIT ETV6 CSF1R CBFB CSF1
9 integument MP:0010771 10.13 KIT ETV6 CSF1R CBFB CSF1 CREBBP
10 craniofacial MP:0005382 10.04 CSF1R KIT CREBBP CBFB CSF1 KMT2A
11 embryo MP:0005380 10.03 ETV6 KIT CREBBP CBFB KMT2A RUNX1
12 limbs/digits/tail MP:0005371 9.93 CSF1R KIT CREBBP CBFB CSF1 KMT2A
13 liver/biliary system MP:0005370 9.91 KIT CREBBP CBFB CSF1 KMT2A RUNX1
14 neoplasm MP:0002006 9.87 FLT3 KIT ETV6 CBFB CREBBP KMT2A
15 no phenotypic analysis MP:0003012 9.86 KIT ETV6 CSF1R FLT3 CBFB CSF1
16 muscle MP:0005369 9.85 KIT CREBBP CSF1 MPO MYH11 KMT2A
17 normal MP:0002873 9.76 CSF1R DNTT KIT ETV6 CREBBP CBFB
18 respiratory system MP:0005388 9.43 KIT CREBBP CBFB CSF1 MYH11 RUNX1
19 skeleton MP:0005390 9.23 CSF1R FLT3 KIT CREBBP CBFB CSF1

Drugs & Therapeutics for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Search Clinical Trials , NIH Clinical Center for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22)

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Genetic tests related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

# Genetic test Affiliating Genes
1 Acute Myelomonocytic Leukemia 28

Anatomical Context for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

MalaCards organs/tissues related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

38
Bone Marrow, Bone, Myeloid

Publications for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Articles related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

(show top 50) (show all 275)
# Title Authors Year
1
Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway. ( 26675333 )
2016
2
A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia. ( 26185647 )
2015
3
MLL-ELL fusion gene in an acute myelomonocytic leukemia patient transformed from acute promyelocytic leukemia. ( 26185637 )
2015
4
Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia. ( 26124967 )
2015
5
RANBP2-ALK fusion combined with monosomy 7 in acute myelomonocytic leukemia. ( 24613277 )
2014
6
Cochlear implantation in a patient with acute myelomonocytic leukemia before allogeneic peripheral blood stem cell transplantation. ( 24560096 )
2014
7
Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins. ( 24523193 )
2014
8
A novel fusion of SQSTM1 and FGFR1 in a patient with acute myelomonocytic leukemia with t(5;8)(q35;p11) translocation. ( 25501022 )
2014
9
Bilateral Adrenal Masses in a Patient in Remission From Acute Myelomonocytic Leukemia. ( 24566206 )
2014
10
Interaction Between Myelomonocytic and Lymphoid Cells in a Patient with Acute MyeloMonocytic Leukemia and Chronic Lymphocytic Leukemia. ( 23987820 )
2013
11
Leukemic ascites as an initial presentation of acute myelomonocytic leukemia with inversion of chromosome 16. ( 23563011 )
2013
12
Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review. ( 23605368 )
2013
13
Thrombomodulin-induced differentiation of acute myelomonocytic leukemia cells via JNK signaling. ( 22342852 )
2012
14
Acute myelomonocytic leukemia presenting with gingival enlargement as the only clinical manifestation. ( 23493961 )
2012
15
p210 BCR/ABL1 as a secondary change in a patient with acute myelomonocytic leukemia (M4Eo) with inv(16). ( 23054652 )
2012
16
Establishment and characterization of a new human acute myelomonocytic leukemia cell line JIH-3. ( 22340903 )
2012
17
Myeloid Sarcoma and Acute Myelomonocytic Leukemia in an Adolescent with Tetrasomy 8: Staging with (18)F-FDG PET/CT. ( 24900045 )
2012
18
CD7-positive acute myelomonocytic leukemia with trisomy 21 as a sole acquired chromosomal abnormality in two adolescents. ( 21592571 )
2011
19
Acute myelomonocytic leukemia (AML-M4) in a dog with the extradural lesion. ( 21060242 )
2011
20
Isolated central nervous system relapse in an adolescent with acute myelomonocytic leukemia, Charcot Marie Tooth syndrome, and paraneoplastic autoantibody. ( 20724950 )
2010
21
Myeloid sarcoma in the nasal cavities that developed during the course of acute myelomonocytic leukemia. ( 21123976 )
2010
22
Double supernumerary isochromosome 4p in acute myelomonocytic leukemia. ( 20863564 )
2010
23
Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases. ( 18818702 )
2009
24
Gemtuzumab ozogamicin-induced long-term remission in a woman with acute myelomonocytic leukemia and bone marrow relapse following allogeneic transplantation. ( 19904520 )
2009
25
Pseudo Chediak-Higashi anomaly in acute myelomonocytic leukemia. ( 19332932 )
2009
26
Treatment-related acute myelomonocytic leukemia with t(11;19) in a child following chemotherapy for hepatoblastoma. ( 17973320 )
2008
27
A dog with acute myelomonocytic leukemia. ( 18628605 )
2008
28
Systemic mastocytosis with acute myelomonocytic leukemia: a case report. ( 23100960 )
2008
29
Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping. ( 17571080 )
2007
30
Parotid involvement in acute myelomonocytic leukemia. ( 17978464 )
2007
31
Mesenteric chloroma with t(16;16) followed by acute myelomonocytic leukemia with clonal evolution. ( 18036407 )
2007
32
Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature. ( 17889707 )
2007
33
Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive). ( 16679933 )
2006
34
[Immunophenotypic and cytogenetic features of acute myelomonocytic leukemia]. ( 17059770 )
2006
35
Acute myelomonocytic leukemia with dysplastic bone marrow eosinophils showing t(5;17)(q13;q11) and a secondary chromosomal aberration, inv(16)(p13q22). ( 17189222 )
2006
36
Dup(1)(p31.2p36.2) in acute myelomonocytic leukemia. ( 16490603 )
2006
37
Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication. ( 17118759 )
2006
38
Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up. ( 17214400 )
2006
39
[Depressing the immune escape of acute myelomonocytic leukemia via an anti-Fas ribozyme]. ( 17096877 )
2006
40
Extra copy of 20q deletion, acute myelomonocytic leukemia (M4) and Niemann-Pick disease. ( 16027483 )
2005
41
Deletion of CBFB in a patient with acute myelomonocytic leukemia (AML M4Eo) and inversion 16. ( 15381374 )
2004
42
Erythema nodosum and granulomatous lesions preceding acute myelomonocytic leukemia. ( 15628321 )
2004
43
Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome. ( 15111789 )
2004
44
Transient atypical monocytosis mimic acute myelomonocytic leukemia in post-chemotherapy patients receiving G-CSF: report of two cases. ( 15485468 )
2004
45
Flow cytometry immunophenotypic characteristics of monocytic population in acute monocytic leukemia (AML-M5), acute myelomonocytic leukemia (AML-M4), and chronic myelomonocytic leukemia (CMML). ( 15603447 )
2004
46
A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. ( 12964013 )
2003
47
A pulmonary syndrome in patients with acute myelomonocytic leukemia and inversion of chromosome 16. ( 12691148 )
2003
48
Re: Oral manifestations of acute myelomonocytic leukemia: a case report and review of the classification of leukemias. Wu J, Fantasia Je, Kaplan R. (2002;73:664-668). ( 12416783 )
2002
49
Oral manifestations of acute myelomonocytic leukemia: a case report and review of the classification of leukemias. ( 12083541 )
2002
50
Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25). ( 12095151 )
2002

Variations for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Expression for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Search GEO for disease gene expression data for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22).

Pathways for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Pathways related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CREBBP CSF1 CSF1R KIT MYH11
2
Show member pathways
12.76 CREBBP CSF1R FLT3 KIT MPO RUNX1
3
Show member pathways
12.73 CREBBP CSF1 CSF1R FLT3 KIT
4 12.6 CREBBP CSF1R FLT3 KIT RUNX1
5 12.52 CSF1 CSF1R FLT3 KIT
6
Show member pathways
12.49 CSF1 CSF1R FLT3 KIT
7 11.88 CSF1R FLT3 KIT
8 11.73 CSF1 FLT3 KIT MPO
9 11.45 CREBBP CSF1R KIT MPO
10 11.37 CSF1R ETV6 FLT3 KMT2A MPO RUNX1
11 11.34 CSF1 CSF1R DNTT FLT3 KIT
12 11.33 CSF1 CSF1R FLT3 KIT
13 11.31 CSF1 CSF1R KIT
14
Show member pathways
11.23 CREBBP CSF1 CSF1R
15 10.84 CREBBP ETV6 FLT3
16 10.77 CSF1 CSF1R FLT3 KIT
17 10.73 CSF1 MPO
18 10.45 CBFB RUNX1

GO Terms for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

Cellular components related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 CSF1 CSF1R FLT3 KIT
2 positive regulation of cell migration GO:0030335 9.82 CSF1 CSF1R KIT
3 protein autophosphorylation GO:0046777 9.78 CSF1R FLT3 KIT
4 peptidyl-tyrosine phosphorylation GO:0018108 9.77 CSF1R FLT3 KIT
5 cytokine-mediated signaling pathway GO:0019221 9.76 CSF1R FLT3 KIT
6 regulation of hematopoietic stem cell differentiation GO:1902036 9.65 CBFB KMT2A RUNX1
7 homeostasis of number of cells within a tissue GO:0048873 9.63 CSF1 KMT2A
8 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.63 FLT3 KIT
9 regulation of Wnt signaling pathway GO:0030111 9.62 CBFB RUNX1
10 cellular response to cytokine stimulus GO:0071345 9.61 CSF1R FLT3
11 osteoclast differentiation GO:0030316 9.6 CSF1 CSF1R
12 macrophage differentiation GO:0030225 9.58 CSF1 CSF1R
13 regulation of megakaryocyte differentiation GO:0045652 9.58 CBFB KMT2A RUNX1
14 definitive hemopoiesis GO:0060216 9.57 CBFB KMT2A
15 regulation of keratinocyte differentiation GO:0045616 9.56 CBFB RUNX1
16 regulation of intracellular estrogen receptor signaling pathway GO:0033146 9.55 CBFB RUNX1
17 embryonic hemopoiesis GO:0035162 9.54 KIT KMT2A
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 CSF1R FLT3 KIT
19 regulation of regulatory T cell differentiation GO:0045589 9.52 CBFB RUNX1
20 regulation of bicellular tight junction assembly GO:2000810 9.51 CBFB RUNX1
21 hematopoietic stem cell proliferation GO:0071425 9.49 ETV6 RUNX1
22 regulation of B cell receptor signaling pathway GO:0050855 9.46 CBFB RUNX1
23 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.46 CSF1 CSF1R FLT3 KIT
24 regulation of cytokine-mediated signaling pathway GO:0001959 9.43 CBFB RUNX1
25 myeloid progenitor cell differentiation GO:0002318 9.32 FLT3 KIT
26 macrophage colony-stimulating factor signaling pathway GO:0038145 9.26 CSF1 CSF1R
27 regulation of myeloid cell differentiation GO:0045637 9.13 CBFB CREBBP RUNX1
28 hemopoiesis GO:0030097 9.02 CSF1 CSF1R FLT3 KIT RUNX1
29 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 CBFB CREBBP ETV6 KMT2A RUNX1

Molecular functions related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.85 CREBBP CSF1R DNTT FLT3 KIT KMT2A
2 DNA binding transcription factor activity GO:0003700 9.72 CBFB CREBBP ETV6 KMT2A RUNX1
3 protein tyrosine kinase activity GO:0004713 9.43 CSF1R FLT3 KIT
4 protein homodimerization activity GO:0042803 9.35 CSF1 CSF1R FLT3 KIT KMT2A
5 cytokine binding GO:0019955 9.16 CSF1R KIT
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 CSF1R FLT3 KIT

Sources for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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