MCID: ACT193
MIFTS: 33

Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) malady

Categories: Rare diseases, Blood diseases, Bone diseases, Immune diseases, Cancer diseases

Aliases & Classifications for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Sources:
46NIH Rare Diseases, 66UMLS, 52Orphanet, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

Name: Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) 46 52
Acute Myelomonocytic Leukemia 46 66
Aml with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) 52
Aml with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16 46
Aml with Inv(16)(p13.1q22) or T(16 46
 
Cbfb-Myh11 46
16)(p13.1 46
16)(p13 46
Q22) 46

Classifications:



External Ids:

Orphanet52 ORPHA98829
ICD10 via Orphanet29 C92.5

Summaries for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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NIH Rare Diseases:46 Acute myelomonocytic leukemia (amml) is a cancer that typically develops in the bone marrow and blood of older individuals.  amml is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly.  symptoms of amml often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia).  the cause of amml is currently unknown.  treatment typically consists of chemotherapy. last updated: 2/12/2013

MalaCards based summary: Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22), also known as acute myelomonocytic leukemia, is related to acute myelomonocytic leukemia and acute myeloid leukemia with t(8;21)(q22;q22) translocation, and has symptoms including fatigue An important gene associated with Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) is CBFB (Core-Binding Factor Beta Subunit), and among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Tyrosine Kinases / Adaptors. The drugs gemtuzumab and gemtuzumab ozogamicin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and myeloid, and related mouse phenotypes are neoplasm and cellular.

Related Diseases for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1acute myelomonocytic leukemia12.6
2acute myeloid leukemia with t(8;21)(q22;q22) translocation12.1
3leukemia, acute promyelocytic, somatic11.2
4leukemia11.0
5mowat-wilson syndrome due to monosomy 2q2210.9
6eosinophilia10.4
7sarcoma10.3
8myeloma10.2
9multiple myeloma10.1
10myelodysplastic syndrome10.1
11lymphoma10.1
12mycosis fungoides10.0
13gingivitis10.0
14metabolic acidosis10.0CBFB, MYH11
15chronic lymphocytic leukemia9.9
16chronic myelomonocytic leukemia9.9
17vasculitis9.9
18myeloid sarcoma9.9
19myeloid leukemia9.9
20macroglobulinemia9.9
21adult central nervous system mature teratoma9.9FLT3, MYH11
22unclassified intestinal pseudoobstruction9.8FLT3, KIT
23acute myeloid leukemia, somatic dnmt3a-related9.8FLT3, KIT
24acute panmyelosis with myelofibrosis9.8FLT3, KIT
25lung cancer9.8
26esophageal cancer9.8
27renal cell carcinoma9.8
28retinoblastoma9.8
29pick disease9.8
30myeloperoxidase deficiency9.8
31acute leukemia9.8
32acute lymphocytic leukemia9.8
33acute monocytic leukemia9.8
34gastric cancer9.8
35niemann-pick disease9.8
36paroxysmal nocturnal hemoglobinuria9.8
37systemic mastocytosis9.8
38hypophosphatemia9.8
39osteomyelitis9.8
40lymphoblastic leukemia9.8
41disseminated intravascular coagulation9.8
42choroiditis9.8
43nephrotic syndrome9.8
44esophagitis9.8
45pancytopenia9.8
46hemolytic-uremic syndrome9.8
47hypercalcemia9.8
48central nervous system leukemia9.8
49leukostasis9.8
50amenorrhea9.8

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):



Diseases related to acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

Symptoms for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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UMLS symptoms related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):


fatigue

Drugs & Therapeutics for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22)

Inferred drug relations via UMLS66/NDF-RT44:

Genetic Tests for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Anatomical Context for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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MalaCards organs/tissues related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

34
Bone marrow, Bone, Myeloid

Animal Models for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils... or affiliated genes

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MGI Mouse Phenotypes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22):

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0CBFB, FLT3, KIT
2MP:00053848.4CBFB, FLT3, KIT, MYH11

Publications for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Variations for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Expression for genes affiliated with Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Search GEO for disease gene expression data for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22).

Pathways for genes affiliated with Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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GO Terms for genes affiliated with Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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Biological processes related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1myeloid progenitor cell differentiationGO:00023189.6FLT3, KIT
2positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.6FLT3, KIT
3protein autophosphorylationGO:00467779.3FLT3, KIT
4peptidyl-tyrosine phosphorylationGO:00181089.2FLT3, KIT
5positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.2FLT3, KIT
6cytokine-mediated signaling pathwayGO:00192219.1FLT3, KIT
7positive regulation of MAPK cascadeGO:00434109.1FLT3, KIT
8hemopoiesisGO:00300979.0FLT3, KIT
9positive regulation of MAP kinase activityGO:00434068.8FLT3, KIT

Molecular functions related to Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils Inv(16)(p13q22) or T(16;16)(p13;q22) according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00047149.1FLT3, KIT

Sources for Acute Myeloid Leukemia with Abnormal Bone Marrow Eosinophils...

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet