MCID: ACT183
MIFTS: 27

Acute Myeloid Leukemia with T Translocation malady

Blood, Cancer categories

Summaries for Acute Myeloid Leukemia with T Translocation

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MalaCards: Acute Myeloid Leukemia with T Translocation is related to myxoid liposarcoma and liposarcoma. An important gene associated with Acute Myeloid Leukemia with T Translocation is RUNX1T1 (runt-related transcription factor 1; translocated to, 1 (cyclin D-related)), and among its related pathways are TGF Beta Signaling Pathway and LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production. The compounds pge2 and asparagine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are respiratory system and nervous system.

Aliases & Classifications for Acute Myeloid Leukemia with T Translocation

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Aliases & Descriptions:

acute myeloid leukemia with t translocation 49


External Ids:

ICD10 via Orphanet26 C92.7

Related Diseases for Acute Myeloid Leukemia with T Translocation

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17GeneCards, 18GeneDecks
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Diseases related to Acute Myeloid Leukemia with T Translocation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 31)
idRelated DiseaseScoreTop Affiliating Genes
1myxoid liposarcoma10.0DDIT3
2liposarcoma10.0DDIT3, FUS
3retinal degeneration10.0JUN
4endometrial carcinoma10.0EP300, HOXA10
5ovarian cancer10.0JUN, RUNX1
6adenocarcinoma10.0EP300, CREBBP
7pancreatic cancer10.0JUN
8rubinstein-taybi syndrome10.0EP300, CREBBP
9cervical cancer10.0EP300, DDIT3, CREBBP
10acute monocytic leukemia10.0KAT6A, CREBBP, NUP98, EP300
11peripheral primitive neuroectodermal tumor10.0DDIT3, EP300, ERG, FUS
12acute myelomonocytic leukemia10.0ETV6, CREBBP, RUNX1
13monocytic leukemia10.0EP300, KAT6A, RUNX1, JUN
14fibrosarcoma10.0JUN, ETV6, EP300
15stomach cancer10.0DDIT3, RUNX1, JUN
16precursor t-cell acute lymphoblastic leukemia10.0HOXA10, ETV6, NUP98, RUNX1
17prostate cancer10.0JUN, CREBBP, DDIT3, EP300
18sarcoma10.0FUS, EP300, ETV6, DDIT3, RUNX1
19acute myeloid leukemia10.0CEBPA, RUNX1
20acute promyelocytic leukemia10.0JUN, RUNX1, RUNX1T1, CREBBP, MEIS1, EP300
21ipex syndrome10.0JUN, PSIP1, CREBBP, NUP98, EP300
22myelodysplastic syndromes10.0RUNX1, CREBBP, NUP98, ETV6, EP300, HOXA9
23t-cell leukemia10.0JUN, CREBBP, EP300, IL5
24chronic myeloid leukemia10.0RUNX1, CREBBP, MEIS1, NUP98, ETV6, HOXA10
25hematologic cancer10.0RUNX1, RUNX1T1, CREBBP, NUP98, ETV6, EP300
26acute lymphocytic leukemia10.0JUN, RUNX1, CREBBP, MEIS1, ETV6, EP300
27retinoblastoma10.0JUN, RUNX1, CREBBP, EP300, CEBPA
28breast cancer10.0JUN, RUNX1, CREBBP, DDIT3, CBFA2T3, ETV6
29acute leukemia10.0RUNX1, RUNX1T1, CREBBP, MEIS1, MLLT4, NUP98
30myeloid leukemia10.0JUN, RUNX1, RUNX1T1, CREBBP, MEIS1, ERG
31leukemia9.9CEBPA, KAT6A, PSIP1, CREBBP, MEIS1, MLLT4

Graphical network of the top 20 diseases related to Acute Myeloid Leukemia with T Translocation:



Diseases related to acute myeloid leukemia with t   translocation

Clinical Features for Acute Myeloid Leukemia with T Translocation

Drugs & Therapeutics for Acute Myeloid Leukemia with T Translocation

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Myeloid Leukemia with T Translocation

Drug clinical trials:

Search ClinicalTrials for Acute Myeloid Leukemia with T Translocation

Search NIH Clinical Center for Acute Myeloid Leukemia with T Translocation

Search CenterWatch for Acute Myeloid Leukemia with T Translocation

Genetic Tests for Acute Myeloid Leukemia with T Translocation

Anatomical Context for Acute Myeloid Leukemia with T Translocation

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33MalaCards
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MalaCards organs/tissues related to Acute Myeloid Leukemia with T Translocation:

33
Myeloid

Animal Models for Acute Myeloid Leukemia with T Translocation or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Acute Myeloid Leukemia with T Translocation:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6JUN, CREBBP, MEIS1, EP300
2MP:00036319.1JUN, RUNX1, CREBBP, MEIS1, HOXA10, ERG
3MP:00053709.0CEBPA, IL5, MEIS1, KAT6A, RUNX1, JUN
4MP:00053899.0RUNX1T1, KAT6A, PSIP1, HOXA9, FUS, CEBPA
5MP:00020068.7RUNX1, CREBBP, ETV6, EP300, IL5, CEBPA
6MP:00053818.4RUNX1T1, KAT6A, CREBBP, ETV6, EP300, HOXA10
7MP:00053908.3JUN, RUNX1, KAT6A, PSIP1, CREBBP, HOXA10
8MP:00107718.2JUN, RUNX1, RUNX1T1, KAT6A, CREBBP, MEIS1
9MP:00053868.1JUN, RUNX1, RUNX1T1, KAT6A, PSIP1, CREBBP
10MP:00028738.1JUN, RUNX1, RUNX1T1, PSIP1, CREBBP, ETV6
11MP:00053798.0JUN, PSIP1, CREBBP, DDIT3, ETV6, HOXA10
12MP:00053857.3JUN, RUNX1, RUNX1T1, KAT6A, CREBBP, MEIS1
13MP:00053767.2JUN, RUNX1, KAT6A, CREBBP, DDIT3, ETV6
14MP:00053846.4MEIS1, CREBBP, PSIP1, KAT6A, RUNX1, JUN
15MP:00107686.3CREBBP, PSIP1, KAT6A, RUNX1T1, RUNX1, JUN
16MP:00053786.2MLLT4, CREBBP, KAT6A, RUNX1T1, RUNX1, JUN
17MP:00053976.2CEBPA, JUN, RUNX1, KAT6A, PSIP1, CREBBP
18MP:00053876.0DDIT3, CREBBP, PSIP1, KAT6A, RUNX1, JUN

Publications for Acute Myeloid Leukemia with T Translocation

Genetic Variations for Acute Myeloid Leukemia with T Translocation

Expression for genes affiliated with Acute Myeloid Leukemia with T Translocation

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myeloid Leukemia with T   Translocation

Search GEO for disease gene expression data for Acute Myeloid Leukemia with T Translocation.

Pathways for genes affiliated with Acute Myeloid Leukemia with T Translocation

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 12EMD Millipore, 30KEGG, 4Cell Signaling Technology
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Pathways related to Acute Myeloid Leukemia with T Translocation according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2EP300
210.0CREBBP, EP300
310.0EP300, CREBBP
49.8CREBBP, EP300, CEBPA
59.8CEBPA, EP300, CREBBP
69.8CEBPA, EP300, CREBBP
79.8CREBBP, EP300, HOXA10
8
Hide members
9.8EP300, CREBBP, JUN
99.8EP300, CREBBP, JUN
10
Development Ligand-dependent activation of the ESR1/AP-1 pathway
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9.8JUN, CREBBP, EP300
119.8JUN, CREBBP, EP300
12
Apoptosis and survival Lymphotoxin-beta receptor signaling
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9.8JUN, CREBBP, EP300
139.8EP300, CREBBP, JUN
149.8JUN, CREBBP, EP300
15
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9.8JUN, CREBBP, EP300
16
Hide members
9.8EP300, CREBBP, JUN
17
Hide members
9.8EP300, CREBBP, JUN
18
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9.8EP300, CREBBP, JUN
199.8EP300, CREBBP, JUN
209.8EP300, CREBBP, JUN
219.8EP300, CREBBP, JUN
229.7CEBPA, EP300, DDIT3
23
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9.7CEBPA, RUNX1T1, RUNX1, JUN
249.6JUN, DDIT3, EP300
259.6CEBPA, EP300, CREBBP, JUN
269.6JUN, CREBBP, EP300, CEBPA
279.5EP300, MLLT4, CREBBP
289.5RUNX1, RUNX1T1, PSIP1, CEBPA
299.5JUN, CREBBP, EP300, IL5
309.5JUN, CREBBP, EP300, IL5
319.4JUN, CREBBP, EP300, HOXA9
329.4PSIP1, CREBBP, EP300, FUS
33
Hide members
9.4PSIP1, CREBBP, EP300, IL5
34
Hide members
9.3EP300, NUP98, CREBBP, JUN
35
Hide members
9.3CEBPA, IL5, EP300, CREBBP, JUN
36
Hide members
9.2JUN, CREBBP, DDIT3, EP300, CEBPA
379.2JUN, RUNX1, RUNX1T1, CREBBP, EP300, CEBPA
38
Hide members
8.9JUN, PSIP1, CREBBP, MLLT4, IL5
39
Hide members
8.8JUN, PSIP1, CREBBP, DDIT3, EP300, IL5
407.5CEBPA, RUNX1, RUNX1T1, MEIS1, DDIT3, ETV6

Compounds for genes affiliated with Acute Myeloid Leukemia with T Translocation

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 29IUPHAR
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Compounds related to Acute Myeloid Leukemia with T Translocation according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1pge24510.4PSIP1
2asparagine459.7EP300, DDIT3, CREBBP
3helenalin459.7EP300, JUN
4arsenite45 2410.7DDIT3, MEIS1, RUNX1, JUN
5ionomycin459.6JUN, DDIT3, EP300, IL5
6vitamin d459.6JUN, CREBBP, EP300, IL5
7retinoid459.6JUN, CREBBP, DDIT3, EP300
8butyrate459.6IL5, EP300, CREBBP, RUNX1, JUN
9sb 20358045 6010.5IL5, EP300, DDIT3, JUN
10etoposide45 50 60 1112.5JUN, RUNX1, CREBBP, DDIT3, EP300
11prednisolone45 29 1111.4IL5, ETV6, RUNX1
12zinc45 2410.3RUNX1, RUNX1T1, KAT6A, CREBBP, EP300, FUS
13testosterone45 60 11 2412.2CREBBP, DDIT3, EP300, HOXA10, IL5
14oligonucleotide459.1JUN, RUNX1, RUNX1T1, NUP98, HOXA10
15vegf458.6JUN, RUNX1, CREBBP, DDIT3, ETV6, EP300
16retinoic acid45 248.9MEIS1, CREBBP, RUNX1, JUN, DDIT3, CBFA2T3
17tyrosine457.1IL5, JUN, RUNX1, PSIP1, CREBBP, MEIS1

GO Terms for genes affiliated with Acute Myeloid Leukemia with T Translocation

Sources:
16Gene Ontology
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Cellular components related to Acute Myeloid Leukemia with T Translocation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase complexGO:00012310.0EP300, CREBBP
2nuclear peripheryGO:0343999.6NUP98, PSIP1
3transcription factor complexGO:0056679.1HOXA9, JUN, CREBBP, MEIS1, EP300, HOXA10
4nucleoplasmGO:0056548.2JUN, PSIP1, CREBBP, DDIT3, CBFA2T3, NUP98
5nucleolusGO:0057308.1RUNX1, KAT6A, PSIP1, MLLT4, CBFA2T3, EP300
6nucleusGO:0056346.0MLLT4, MEIS1, CREBBP, PSIP1, KAT6A, RUNX1

Biological processes related to Acute Myeloid Leukemia with T Translocation according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1N-terminal peptidyl-lysine acetylationGO:01807610.1EP300, CREBBP
2definitive hemopoiesisGO:06021610.0RUNX1, MEIS1, HOXA9
3myeloid cell differentiationGO:03009910.0RUNX1, KAT6A, CEBPA
4histone acetylationGO:0165739.9CREBBP, KAT6A
5positive regulation by host of viral transcriptionGO:0439239.9JUN, EP300
6liver developmentGO:0018899.8CEBPA, RUNX1, JUN
7negative regulation of myeloid cell differentiationGO:0456389.7HOXA9, MEIS1
8modulation by virus of host morphology or physiologyGO:0190489.1PSIP1, CREBBP, NUP98, EP300, CEBPA
9positive regulation of transcription, DNA-dependentGO:0458939.0JUN, RUNX1, KAT6A, CREBBP, DDIT3, IL5
10positive regulation of transcription from RNA polymerase II promoterGO:0459448.8CEBPA, EP300, CBFA2T3, DDIT3, PSIP1, RUNX1
11transcription, DNA-dependentGO:0063517.3CEBPA, RUNX1, RUNX1T1, KAT6A, PSIP1, CBFA2T3

Molecular functions related to Acute Myeloid Leukemia with T Translocation according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1HMG box domain bindingGO:07183710.0CEBPA, JUN
2acetyltransferase activityGO:0164079.9EP300, CREBBP, KAT6A
3RNA polymerase II activating transcription factor bindingGO:0011029.9JUN, CREBBP, EP300
4histone acetyltransferase activityGO:0044029.7EP300, CREBBP, KAT6A
5RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:0037059.7CEBPA, MEIS1, JUN
6activating transcription factor bindingGO:0336139.6EP300, PSIP1
7transcription coactivator activityGO:0037139.4JUN, KAT6A, CREBBP, EP300
8chromatin bindingGO:0036829.0KAT6A, PSIP1, CREBBP, MEIS1, CBFA2T3, EP300
9transcription factor bindingGO:0081348.9JUN, RUNX1, KAT6A, CREBBP, DDIT3, EP300
10sequence-specific DNA bindingGO:0435658.3MEIS1, DDIT3, ETV6, HOXA10, HOXA9, ERG
11DNA bindingGO:0036778.2JUN, RUNX1, RUNX1T1, KAT6A, DDIT3, EP300
12sequence-specific DNA binding transcription factor activityGO:0037006.6CEBPA, JUN, RUNX1, RUNX1T1, GAS7, CREBBP
13protein bindingGO:0055154.9MLLT4, MEIS1, CREBBP, PSIP1, KAT6A, RUNX1T1

Products for genes affiliated with Acute Myeloid Leukemia with T Translocation

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Sources for Acute Myeloid Leukemia with T Translocation

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet