MCID: ACT075
MIFTS: 57

Acute Myocardial Infarction malady

Genetic diseases (common), Cardiovascular diseases categories

Aliases & Classifications for Acute Myocardial Infarction

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Acute Myocardial Infarction, Aliases & Descriptions:

Name: Acute Myocardial Infarction 30 9 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:9408
ICD9CM27 410.9, 410.90, 410
NCIt38 C35204
ICD1025 I21

Summaries for Acute Myocardial Infarction

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MalaCards based summary: Acute Myocardial Infarction is related to cardiac rupture and cardiogenic shock. An important gene associated with Acute Myocardial Infarction is NPPA (natriuretic peptide A), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and A-beta Plaque Formation and APP Metabolism. The compounds dobutamine and enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are behavior/neurological and muscle.

Related Diseases for Acute Myocardial Infarction

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Diseases in the Myocardial Infarction family:

acute myocardial infarction Posterior Myocardial Infarction
Myocardial Infarction, Susceptibility to, 1

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1cardiac rupture32.2PLAT, CHKB
2cardiogenic shock32.2PIK3C2A, PLAT, NPPB
3coronary thrombosis31.7PLAT, F3
4congestive heart failure31.5TNNT2, TNNI3
5myocarditis31.4NPPB, MB, CHKB, TNNI3, TNNT2
6atrial fibrillation31.4CHKB, ACE, PLAT, NPPA, NPPB
7coronary artery vasospasm31.2AHSP, CHKB
8kawasaki disease31.2ADM, CRP, NPPB
9rheumatic disease31.1CRP
10atrioventricular block31.1PIK3C2A, NPPB
11sick sinus syndrome31.0NPPA
12factor xiii deficiency30.9F3
13syndrome of inappropriate antidiuretic hormone30.9NPPA, NPPB
14pericardial effusion30.9CHKB, PIK3C2A
15status asthmaticus30.9PIK3C2A
16antiphospholipid syndrome30.8PLAT, F3, SULT1A3
17obesity30.8SULT1A3, FABP12, FABP3, SAA4, CRP
18neuroleptic malignant syndrome30.8PIK3C2A, CHKB, MB
19thrombocytosis30.8SERPINF2, F3, CRP
20peripheral vascular disease30.8PLAT, F3
21thrombophilia30.7PLAT, F3, SERPINF2
22polymyositis30.7PIK3C2A, CHKB, MB
23pneumonia30.7PIK3C2A, ADM, SAA4, CRP, MB
24respiratory failure30.6PIK3C2A, F3, CRP
25acute pancreatitis30.5SULT1A3, CRP, MB
26vasculitis30.5PTX3, SULT1A3, CRP
27intermediate coronary syndrome30.4PIK3C2A, TNNT2, TNNI3, PLAT, MB
28arthritis30.3SULT1A3, SAA4, CRP, MB
29hypertrophic cardiomyopathy30.3TNNI3, TNNT2
30proteinuria30.2CRP, ACE, SAA4, ADM, PIK3C2A
31disseminated intravascular coagulation30.2PIK3C2A, SERPINF2, F3, PLAT, MB
32rheumatoid arthritis30.2MB, CRP, SAA4, CHKB, PTX3
33ischemia30.1PIK3C2A, AHSP, TNNT2, CTF1, NPPB, MB
34pulmonary embolism30.0SERPINF2, FABP3, F3, PLAT, NPPB
35vascular disease29.9CRP, PLAT, ACE, F3, SULT1A3, AHSP
36coronary artery disease29.7CRP, MB, NPPA, NPPB, CTF1, PLAT
37myocardial infarction29.3FABP12, FABP3, SAA4, F3, ACE, PLAT
38atherosclerosis29.1SULT1A3, SERPINF2, PTX3, AHSP, FABP12, SAA4
39endotheliitis11.0
40aneurysm10.9
41angina pectoris10.9
42right bundle branch block10.9
43artery disease10.8
44blindness10.8
45spontaneous coronary artery dissection10.8
46coronary aneurysm10.7
47acute myocarditis10.7
48coronary artery aneurysm10.7
49coronary stenosis10.7
50dextrocardia10.6

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to acute myocardial infarction

Symptoms for Acute Myocardial Infarction

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Drugs & Therapeutics for Acute Myocardial Infarction

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Drug clinical trials:

Search ClinicalTrials for Acute Myocardial Infarction

Search NIH Clinical Center for Acute Myocardial Infarction

Genetic Tests for Acute Myocardial Infarction

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Anatomical Context for Acute Myocardial Infarction

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MalaCards organs/tissues related to Acute Myocardial Infarction:

31
Heart, Endothelial, Brain, Monocytes, Testes, Bone, Neutrophil, Bone marrow, Myeloid, T cells, Thyroid, Prostate, Testis, Whole blood, Kidney, Skeletal muscle, Liver, Lung, Spinal cord, Spleen, Small intestine, Pituitary

Animal Models for Acute Myocardial Infarction or affiliated genes

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MGI Mouse Phenotypes related to Acute Myocardial Infarction:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2TNNI3, ADM, CHKB, FABP3, F3, ACE
2MP:00053698.1NPPB, TNNT2, TNNI3, ADM, CHKB, FABP3
3MP:00053848.0PTX3, ADM, F3, ACE, PLAT, MB
4MP:00053857.8TNNT2, TNNI3, ADM, FABP3, F3, ACE
5MP:00053977.5PIK3C2A, AHSP, PTX3, ADM, F3, ACE
6MP:00107687.4PIK3C2A, AHSP, TNNT2, TNNI3, ADM, FABP3
7MP:00053877.3PIK3C2A, AHSP, PTX3, ADM, F3, ACE
8MP:00053766.8CHKB, ADM, SERPINF2, TNNT2, PIK3C2A, FABP3

Publications for Acute Myocardial Infarction

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Articles related to Acute Myocardial Infarction:

(show top 50)    (show all 2540)
idTitleAuthorsYear
1
Acute myocardial infarction in Kabuki syndrome: chance occurrence or a novel risk factor for premature atherosclerosis? (25065336)
2014
2
Reactive thrombocytosis leading to acute myocardial infarction. (24772734)
2013
3
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
4
The Relationship of Acute Myocardial Infarction With or Without ST-Segment Elevation and Viscosity. (23742945)
2013
5
Endoscopy after acute myocardial infarction: an evaluation of safety. (24096947)
2013
6
The angiotensinogen gene M235T polymorphism and acute myocardial infarction risk: a meta-analysis of 22 studies. (23666149)
2013
7
Comparison of cancer risk associated with low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction in women versus men. (23972348)
2013
8
Validity of the GRACE score for 6-month death or reinfarction after presentation with acute myocardial infarction in patients 80 years of age and older. (23965947)
2013
9
Acute myocardial infarction in patients with chronic kidney disease: how are the most vulnerable patients doing? (23903416)
2013
10
Cardiovascular outcomes using intra-aortic balloon pump in high-risk acute myocardial infarction with or without cardiogenic shock: a meta-analysis. (21335478)
2012
11
Association of platelet collagen receptor polymorphisms with premature acute myocardial infarction. (22627583)
2012
12
Diagnostic performance of high-sensitivity troponin T, myeloperoxidase, and pregnancy-associated plasma protein A assays for triage of patients with acute myocardial infarction. (21779191)
2011
13
Appraisal of the prognosis in patients with acute myocardial infarction treated with primary percutaneous coronary intervention. (19568720)
2009
14
The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. (19637097)
2009
15
Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients. (19540141)
2009
16
Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. (18997620)
2009
17
Enhanced proinflammatory response of mononuclear cells to in vitro LPS-challenge in patients with ventricular fibrillation in the setting of acute myocardial infarction. (18571935)
2008
18
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments. (17726257)
2007
19
Dynamics and source of endothelin-1 and interleukin-6 following coronary reperfusion in patients with acute myocardial infarction. (17507790)
2007
20
Glomerular filtration rate on admission independently predicts short-term in-hospital mortality after acute myocardial infarction. (16926535)
2006
21
Relationship between the mismatch of 123I-BMIPP and 201Tl myocardial single-photon emission computed tomography and autonomic nervous system activity in patients with acute myocardial infarction. (16607047)
2006
22
On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease. (16251892)
2006
23
Kinetics of chemokines in acute myocardial infarction. (15928736)
2005
24
Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy. (14965340)
2004
25
Noninvasive estimation of impaired hemodynamics for patients with acute myocardial infarction by Tei index. (15163931)
2004
26
The pro- and anti-inflammatory markers in patients with acute myocardial infarction and chronic stable angina. (15254785)
2004
27
Acute myocardial infarction probably caused by paradoxical embolus in a pregnant woman. (14966073)
2004
28
Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. (12520145)
2003
29
Pleiotropic effects of cytokines on acute myocardial infarction: G-CSF as a novel therapy for acute myocardial infarction. (12769752)
2003
30
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
31
Acute myocardial infarction: a rare complication of protein C deficiency. (11294179)
2001
32
Soluble P-selectin and the success of thrombolysis in acute myocardial infarction. (11461745)
2001
33
Biochemical markers in the management of suspected acute myocardial infarction in the emergency department. (11310455)
2001
34
Survival outcomes 1 year after reperfusion therapy with either alteplase or reteplase for acute myocardial infarction: results from the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO) III Trial. (11023929)
2000
35
Intracranial hemorrhage rates and effect of immediate beta-blocker use in patients with acute myocardial infarction treated with tissue plasminogen activator. Participants in the National Registry of Myocardial Infarction-2. (11078295)
2000
36
Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction. (10816061)
2000
37
Prehospital management of acute myocardial infarction: Electrocardiogram acquisition and interpretation, and thrombolysis by prehospital care providers. (9852937)
1998
38
Plasma levels of adrenomedullin in patients with acute myocardial infarction. (9536921)
1998
39
Elevated plasma levels of interleukin-1 receptor antagonist and interleukin-10 in patients with acute myocardial infarction. (9085939)
1997
40
Effects of ramipril and spironolactone on ventricular remodeling after acute myocardial infarction: randomized and double-blind study]. (9515282)
1997
41
Captopril reduced plasminogen activator inhibitor activity in patients with acute myocardial infarction. (9152782)
1997
42
Evolution of haptoglobin concentration in serum during the early phase of acute myocardial infarction. (9056748)
1997
43
The prognostic value of predischarge quantitative two-dimensional echocardiographic measurements and the effects of early lisinopril treatment on left ventricular structure and function after acute myocardial infarction in the GISSI-3 Trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. (8922912)
1996
44
Clinical benefit of angiotensin converting enzyme inhibition after acute myocardial infarction: myocardial reperfusion revisited. (9023710)
1996
45
Brazilian study with alteplase in acute myocardial infarction--EBRALT]. (8554497)
1995
46
Urinary albumin excretion increases during an acute myocardial infarct especially in patients who develop heart failure]. (7498633)
1995
47
The use of myoglobin for the early diagnosis of reperfusion in acute myocardial infarct]. (8087811)
1994
48
Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors. (8429112)
1993
49
Cardiac rupture, a clinically predictable complication of acute myocardial infarction: report of 70 cases with clinicopathologic correlations. (8354804)
1993
50
Serum elastinolytic activity and blood lipids in various clinical forms of arteriosclerosis and in acute myocardial infarct]. (2047114)
1991

Variations for Acute Myocardial Infarction

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Expression for genes affiliated with Acute Myocardial Infarction

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LifeMap Discovery
Genes differentially expressed in tissues of Acute Myocardial Infarction patients vs. healthy controls: 30
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1EGR3early growth response 3Blood+5.520.000
2LOC286058uncharacterized LOC286058Blood+4.730.000
3IL8interleukin 8Blood+3.510.004
4LEPleptinHeart+3.450.011
5ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinBlood+3.180.007

Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for genes affiliated with Acute Myocardial Infarction

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Pathways related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1NPPB, NPPA
210.0PLAT, ACE
39.9SERPINF2, PLAT
49.8CTF1, NPPB, NPPA
5
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.7TNNT2, TNNI3, ACE
6
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.5SERPINF2, F3, PLAT
7
Show member pathways
9.5PLAT, F3, SERPINF2
8
Show member pathways
thioredoxin pathway36
9.5CRP, PLAT, SAA4

Compounds for genes affiliated with Acute Myocardial Infarction

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Compounds related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1dobutamine43 28 49 1213.0PLAT, NPPA, NPPB, CHKB
2enalaprilat439.9ACE, PLAT, NPPA, NPPB
3fosinopril43 1210.9NPPB, NPPA, CRP, ACE
4quinapril43 49 1211.9CRP, ACE, PLAT, NPPA
5omapatrilat439.8ADM, ACE, PLAT, NPPA
6perindopril43 49 1211.7ACE, PLAT, CRP, NPPA, NPPB
7ramipril43 1210.7ACE, CRP, NPPA, NPPB
8spec-t439.6ADM, CHKB, PLAT, NPPA, NPPB
9thallium439.6PIK3C2A, NPPB, FABP3, CHKB
10clopidogrel43 49 24 1212.6CHKB, F3, ACE, PLAT, CRP
11tirofiban43 1210.6NPPB, CRP, PLAT, F3
128-bromo cgmp439.4ADM, NPPA, AHSP, NPPB
13losartan43 49 28 1212.3ADM, NPPB, NPPA, CRP, ACE, PLAT
14kininogen439.3PLAT, SERPINF2, ACE, F3, NPPA
15mibg439.3NPPA, ADM, PIK3C2A, FABP3, NPPB
16captopril43 59 49 28 1213.2F3, AHSP, ADM, ACE, NPPB, NPPA
17fluvastatin43 49 28 1212.1ACE, MB, CRP, PIK3C2A, CHKB, PLAT
18atorvastatin43 49 28 24 1213.1PIK3C2A, NPPB, CRP, ACE, PLAT, CHKB
19aprotinin43 1210.0PLAT, NPPB, F3, SERPINF2, MB
20citrate438.9FABP3, F3, CRP, MB, CHKB, PIK3C2A
21pravastatin43 49 28 24 1212.9ACE, CRP, CHKB, PIK3C2A, NPPB
22thyroxine43 249.8PIK3C2A, CHKB, PLAT, MB, NPPB, SERPINF2
23catecholamine438.8NPPA, CHKB, PIK3C2A, SULT1A3, ADM, NPPB
24isoproterenol43 129.7PLAT, NPPA, NPPB, PIK3C2A, AHSP, ADM
25sodium nitroprusside438.7ADM, NPPB, PIK3C2A, NPPA, MB, PLAT
26aspirin43 49 28 2411.6ACE, CHKB, SULT1A3, AHSP, PLAT, CRP
27acetylcholine43 49 28 24 1212.5NPPB, MB, AHSP, PIK3C2A, ADM, ACE
28endotoxin438.4AHSP, F3, SERPINF2, ADM, CHKB, SAA4
29prostaglandin f2alpha438.4ADM, FABP12, CRP, MB, SAA4, AHSP
30potassium43 24 1210.3NPPA, CHKB, ADM, TNNI3, PIK3C2A, ACE
31uric acid43 249.2CHKB, FABP12, NPPB, CRP, SAA4, PIK3C2A
32prostacyclin438.1NPPB, NPPA, CRP, PLAT, ACE, F3
33testosterone43 59 24 1211.0MB, NPPB, NPPA, CRP, CHKB, ADM
34vegf438.0CHKB, F3, CRP, MB, PIK3C2A, SERPINF2
35nitroglycerin43 128.9PLAT, CRP, NPPA, NPPB, ACE, F3
36epinephrine43 24 129.9ADM, SERPINF2, PIK3C2A, CHKB, F3, SULT1A3
37arginine437.8PIK3C2A, SERPINF2, NPPA, MB, CHKB, ADM
38ptca437.8PIK3C2A, TNNT2, SERPINF2, ADM, CHKB, SAA4
39heparin43 28 24 1210.6NPPB, SULT1A3, F3, MB, CHKB, SERPINF2
40norepinephrine43 24 129.6ACE, PIK3C2A, SULT1A3, ADM, CHKB, FABP3
41homocysteine43 248.6PIK3C2A, AHSP, SULT1A3, ADM, SAA4, F3
42fibrinogen437.6AHSP, SERPINF2, CHKB, SAA4, F3, PLAT
43fatty acid437.5CHKB, FABP12, ADM, NPPB, FABP3, PIK3C2A
44lactate437.4MB, FABP12, PIK3C2A, FABP3, CRP, NPPB
45alanine437.3SERPINF2, PIK3C2A, TNNT2, CHKB, F3, MB
46glucose436.9CRP, PIK3C2A, AHSP, ADM, NPPB, PLAT
47lipid436.4NPPB, CRP, ACE, SAA4, FABP12, ADM
48calcium43 49 24 129.4TNNI3, CRP, PIK3C2A, AHSP, SERPINF2, FABP12
49cholesterol43 28 24 128.8PIK3C2A, AHSP, PTX3, FABP3, CRP, PLAT
50creatinine435.0PIK3C2A, CRP, MB, NPPA, NPPB, PLAT

GO Terms for genes affiliated with Acute Myocardial Infarction

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Cellular components related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:00058619.9TNNI3, TNNT2
2extracellular spaceGO:00056157.6SERPINF2, ADM, F3, ACE, PLAT, CRP
3extracellular regionGO:00055767.1CTF1, PTX3, SERPINF2, ADM, SAA4, ACE

Biological processes related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:000618210.2NPPB, NPPA
2negative regulation of ATPase activityGO:003278010.1TNNT2, TNNI3
3regulation of vasodilationGO:004231210.1NPPB, ACE
4receptor guanylyl cyclase signaling pathwayGO:000716810.1NPPA, NPPB
5regulation of blood pressureGO:000821710.0NPPB, NPPA, ACE
6regulation of blood vessel sizeGO:005088010.0NPPB, NPPA
7response to insulinGO:00328689.9NPPA, FABP3, ADM
8opsonizationGO:00082289.8CRP, PTX3
9heart developmentGO:00075079.6MB, ADM, TNNI3
10fibrinolysisGO:00427309.6PLAT, SERPINF2
11acute-phase responseGO:00069539.5SERPINF2, SAA4, CRP
12response to hypoxiaGO:00016669.5NPPA, MB, CRP, PLAT, ADM

Molecular functions related to Acute Myocardial Infarction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.7NPPB, NPPA, ADM
2troponin C bindingGO:00301729.6TNNI3, TNNT2

Products for genes affiliated with Acute Myocardial Infarction

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Sources for Acute Myocardial Infarction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet