MCID: ACT075
MIFTS: 61

Acute Myocardial Infarction malady

Cardiovascular diseases category

Summaries for Acute Myocardial Infarction

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32MalaCards
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MalaCards: Acute Myocardial Infarction is related to myocardial infarction and coronary artery disease. An important gene associated with Acute Myocardial Infarction is NPPA (natriuretic peptide A), and among its related pathways are Selenium Pathway and Complement and coagulation cascades. The compounds creatinine and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Acute Myocardial Infarction

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

acute myocardial infarction 8 44 60


External Ids:

Disease Ontology8 DOID:9408
ICD9CM27 410, 410.9, 410.90
NCIt39 C35204
ICD1025 I21

Related Diseases for Acute Myocardial Infarction

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17GeneCards, 18GeneDecks
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Diseases in the Myocardial Infarction family:

Posterior Myocardial Infarction acute myocardial infarction
Myocardial Infarction, Susceptibility to, 1 Myocardial Infarction 2

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 317)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction32.7SAA4, MB, TNNT2, TNNI3, NPPB, NPPA
2coronary artery disease31.1SELP, ACE, THBD, PLAT, AHSP, CHKB
3coronary stenosis31.1SELP
4myocarditis31.0MB, TNNT2, TNNI3, NPPB, CHKB
5diabetes mellitus31.0NPPB, NPPA, PIK3C2A, CRP, PLAT, THBD
6hypertension31.0NPPB, NPPA, CRP, PLAT, ACE, ADM
7ischemia30.8CHKB, SELP, ADM, MB, PLAT, AHSP
8atherosclerosis30.8CRP, AHSP, PLAT, THBD, ACE, PTX3
9stroke, ischemic30.8SELP, THBD, PLAT
10congestive heart failure30.8NPPB, NPPA, FABP3, CTF1, ACE, ADM
11obesity30.8SAA4, FABP12, FABP3, CRP
12hyperhomocysteinemia30.7CRP, PLAT, SELP, THBD
13coronary artery vasospasm30.7AHSP, CHKB
14hyperglycemia30.7ACE, CRP, AHSP
15lupus erythematosus30.7THBD
16ventricular septal defect30.7TNNI3
17thrombophilia30.6PLAT, THBD, SELP, SERPINF2
18thrombocytosis30.6SERPINF2, SELP, THBD, CRP
19kawasaki disease30.6ADM, CRP, NPPB
20thrombocytopenia30.6PIK3C2A, SELP, THBD
21antiphospholipid syndrome30.6SELP, PLAT, THBD
22systemic lupus erythematosus30.6CRP
23pneumonia30.5CRP, ADM, PIK3C2A, MB, SAA4
24cerebrovascular disease30.5SELP, ACE, ADM
25leukemia30.5CTF1, FABP12, SERPINF2
26hyperuricemia30.5PIK3C2A
27ischemic heart disease30.4TNNI3, TNNT2, MB, NPPB, ADM, SELP
28type 2 diabetes mellitus30.4SELP, CRP, PLAT, SERPINF2, ACE, THBD
29intermediate coronary syndrome30.4PIK3C2A, TNNI3, TNNT2, MB, PLAT
30disseminated intravascular coagulation30.4MB, PLAT, PIK3C2A, THBD, SERPINF2
31vasculitis30.4PTX3, THBD, CRP, SELP
32dementia30.4PIK3C2A, FABP3
33arteriosclerosis30.4ADM, AHSP
34periodontal disease30.4CRP, SERPINF2
35neuropathy30.4PIK3C2A, MB
36pheochromocytoma30.4NPPA, ADM
37sleep disorder30.4CHKB
38atrioventricular block30.4NPPB, PIK3C2A
39rheumatoid arthritis30.1SAA4, CHKB, MB, CRP, SELP, PTX3
40vascular disease30.1CRP, AHSP, SELP, ACE, THBD, PLAT
41proteinuria30.1CRP, ADM, SAA4, PIK3C2A, ACE
42pulmonary embolism30.1NPPB, FABP3, PLAT, SERPINF2
43arthritis30.1CRP, MB, SAA4
44neuroleptic malignant syndrome30.1MB, PIK3C2A, CHKB
45hypertrophic cardiomyopathy30.1TNNI3, TNNT2
46respiratory failure30.1PIK3C2A, CRP
47cardiac rupture30.1CHKB, PLAT
48acute pancreatitis30.1CRP, MB
49polycythemia vera30.1THBD, SELP
50eosinophilia30.1PIK3C2A, MB

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to acute myocardial infarction

Clinical Features for Acute Myocardial Infarction

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Drugs & Therapeutics for Acute Myocardial Infarction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Myocardial Infarction

Drug clinical trials:

Search ClinicalTrials for Acute Myocardial Infarction

Search NIH Clinical Center for Acute Myocardial Infarction

Search CenterWatch for Acute Myocardial Infarction

Genetic Tests for Acute Myocardial Infarction

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Anatomical Context for Acute Myocardial Infarction

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32MalaCards
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MalaCards organs/tissues related to Acute Myocardial Infarction:

32
Heart, Endothelial, Brain, Monocytes, Testes, Bone, Bone marrow, Kidney, Prostate, Thyroid, Lung, Liver, Whole blood, Skeletal muscle, Atrioventricular node, Spinal cord, Myeloid, T cells, Spleen, Small intestine, Pituitary

Animal Models for Acute Myocardial Infarction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Myocardial Infarction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2CTF1, FABP3, PLAT, NPPA, PIK3C2A, CRP
2MP:000538512.0ADM, MB, TNNT2, TNNI3, NPPB, NPPA
3MP:001076811.7MB, FABP3, TNNI3, TNNT2, PIK3C2A, AHSP
4MP:000536911.6FABP3, MB, TNNT2, TNNI3, NPPB, CHKB
5MP:000538711.4THBD, ADM, SELP, PTX3, ACE, PLAT
6MP:000539711.4MB, PIK3C2A, PLAT, THBD, ACE, AHSP
7MP:000538811.0PTX3, THBD, TNNI3, MB
8MP:000536710.8ADM, NPPA, PIK3C2A, THBD, ACE, SELP

Publications for Acute Myocardial Infarction

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50PubMed
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Articles related to Acute Myocardial Infarction:

(show top 50)    (show all 2975)
idTitleAuthorsYear
1
Diagnosis of acute myocardial infarction on computed tomography angiogram. (24421363)
2014
2
Trial design and rationale of TY-51924 as a novel Na(+)/H(+) exchanger inhibitor in patients with ST-elevation acute myocardial infarction undergoing percutaneous coronary intervention. (23860273)
2014
3
Predictive value of lipoprotein indices for residual risk of acute myocardial infarction and sudden death in men with low-density lipoprotein cholesterol levels <120 mg/dl. (23831165)
2013
4
Impact of cell number and microvascular obstruction in patients with bone-marrow derived cell therapy: final results from the randomized, double-blind, placebo controlled intracoronary Stem Cell therapy in patients with Acute Myocardial Infarction (SCAMI) trial. (23896972)
2013
5
In-hospital Mortality Due to Acute Myocardial Infarction. Relevance of Type of Hospital and Care Provided. RECALCAR Study. (24035242)
2013
6
Epigastric pain in a 63-year-old woman. Atrial flutter with 2:1 atrioventricular block; acute inferoposterior myocardial infarction. (24350531)
2013
7
Heart-type fatty acid-binding protein may exclude acute myocardial infarction on admission to emergency department for chest pain. (24191843)
2013
8
Mutations of the connexin 37 and 40 gap-junction genes in patients with acute myocardial infarction. (23724624)
2013
9
Postconditioning during percutaneous coronary intervention in acute myocardial infarction: continued difficulty in translation. (24068775)
2013
10
The impact of physical and psychological comorbid conditions on the quality of life of patients with acute myocardial infarction: a multi-center, cross-sectional observational study from Turkey. (23977815)
2013
11
Electromechanical left atrial disturbances in acute inferior myocardial infarction: an evidence for ischaemic dysfunction. (21641055)
2011
12
Effect of prodromal angina pectoris on the infarct progression in patients with first ST-elevation acute myocardial infarction. (20574134)
2010
13
Influence of granulocyte colony-stimulating factor on cardiac function in patients with acute myocardial infarction and leukopenia after revascularization. (20819563)
2010
14
Does silent myocardial infarction add prognostic value in ST-elevation myocardial infarction patients without a history of prior myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Trial. (20934561)
2010
15
Molecular magnetic resonance imaging of myocardial angiogenesis after acute myocardial infarction. (20124125)
2010
16
Usefulness of intra-aortic balloon pump counterpulsation in patients with cardiogenic shock from acute myocardial infarction. (19616662)
2009
17
Primary percutaneous coronary intervention for acute myocardial infarction in a patient with dextrocardia. (19387966)
2009
18
Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction. (19944317)
2009
19
Can short-long-short sequences predict atrial fibrillation in acute inferior myocardial infarction? (17467830)
2008
20
Relationship between the mismatch of 123I-BMIPP and 201Tl myocardial single-photon emission computed tomography and autonomic nervous system activity in patients with acute myocardial infarction. (16607047)
2006
21
Treatment with statins after acute myocardial infarction in patients >or=80 years: underuse despite general acceptance of drug therapy for secondary prevention. (16315337)
2006
22
The influence of thrombolytic therapy on C-reactive protein in ST-segment elevation acute myocardial infarction. (16897925)
2006
23
Predictors of sub-acute stent thrombosis in acute myocardial infarction patients following primary coronary stenting with bare metal stent. (16434807)
2006
24
Left ventricular remodeling and systolic deterioration in acute myocardial infarction: findings from the Stent-PAMI Study. (16115154)
2005
25
Plasma natriuretic peptides up to 2 years after acute myocardial infarction and relation to prognosis: an OPTIMAAL substudy. (16198243)
2005
26
Non-pneumonic Klebsiella oxytoca myopericarditis simulating acute anterolateral myocardial infarction. (15993738)
2005
27
Mortality rates in elderly patients who take different angiotensin-converting enzyme inhibitors after acute myocardial infarction: a class effect? (15262665)
2004
28
Secondary prevention after acute myocardial infarction in four Canadian provinces, 1997-2000. (14968144)
2004
29
Cardiac rupture in acute myocardial infarction with ST segment elevation. Clinical course and prognosis. (15457279)
2004
30
Increases in interleukin-6 and matrix metalloproteinase-9 in the infarct-related coronary artery of acute myocardial infarction. (15118287)
2004
31
The diagnostic value of troponin T and myoglobin levels in acute myocardial infarction: a study in Turkish patients. (12760310)
2003
32
Angioplasty in acute myocardial infarction after low-dose alteplase and abciximab in transferred patients. A comparison with primary angioplasty on site. (12848087)
2003
33
Drug prescriptions after acute myocardial infarction: dosage, compliance, and persistence. (12660666)
2003
34
Drug treatment of elderly patients with acute myocardial infarction: practical recommendations. (11772121)
2001
35
Expression of matrix metalloproteinases in patients with acute myocardial infarction. (11216828)
2001
36
Intracranial hemorrhage rates and effect of immediate beta-blocker use in patients with acute myocardial infarction treated with tissue plasminogen activator. Participants in the National Registry of Myocardial Infarction-2. (11078295)
2000
37
Payer status and the utilization of hospital resources in acute myocardial infarction: a report from the National Registry of Myocardial Infarction 2. (10737281)
2000
38
Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. (10933737)
2000
39
Variation of blood lipids and circulatory endocrine factors in patients with acute myocardial infarction]. (12212118)
2000
40
C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction. (10601349)
1999
41
Early use of ACE inhibitors in the treatment of acute myocardial infarction in the United States: experience from the National Registry of Myocardial Infarction 2. National Registry of Myocardial Infarction 2 participants. (10569326)
1999
42
Evolution of haptoglobin concentration in serum during the early phase of acute myocardial infarction. (9056748)
1997
43
MB fraction of cumulative creatine kinase correlates with insulin secretion in patients with acute myocardial infarction: insulin as a possible determinant of myocardial MB creatine kinase. (8554015)
1996
44
C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction. (8615301)
1996
45
Plasma brain natriuretic peptide concentrations predict survival after acute myocardial infarction. (8636550)
1996
46
Brazilian study with alteplase in acute myocardial infarction--EBRALT]. (8554497)
1995
47
Recombinant hirudin and front-loaded alteplase in acute myocardial infarction: final results of a pilot study. HIT-I (hirudin for the improvement of thrombolysis). (8542868)
1995
48
Hirudin: initial results in acute myocardial infarction, unstable angina and angioplasty. (7775712)
1995
49
Precordial ST segment depression during acute inferior myocardial infarction: early thallium-201 scintigraphic evidence of adjacent posterolateral or inferoseptal involvement. (3968304)
1985
50
Anterior S-T changes during acute inferior myocardial infarction. (6642777)
1983

Genetic Variations for Acute Myocardial Infarction

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Expression for genes affiliated with Acute Myocardial Infarction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myocardial Infarction

Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for genes affiliated with Acute Myocardial Infarction

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37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems
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Pathways related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8SAA4, CRP, PLAT
2
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10.8SERPINF2, PLAT, THBD
3
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10.8THBD, SERPINF2, PLAT
4
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10.8THBD, SERPINF2, SELP
510.7SERPINF2, PLAT

Compounds for genes affiliated with Acute Myocardial Infarction

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1creatinine4412.8CHKB, PIK3C2A, FABP3, FABP12, SAA4, MB
2cholesterol44 28 11 2415.5SAA4, FABP12, FABP3, PIK3C2A, CRP, CHKB
3lactate4412.2PIK3C2A, MB, TNNT2, TNNI3, ADM, SELP
4glucose4412.2PIK3C2A, FABP3, FABP12, NPPB, CRP, SAA4
5ptca4412.0CHKB, PLAT, THBD, SELP, SERPINF2, ADM
6nitroglycerin44 1113.0CRP, ADM, SELP, ACE, PLAT, AHSP
7prostacyclin4412.0NPPB, PIK3C2A, CRP, AHSP, PLAT, THBD
8lipid4412.0ACE, PIK3C2A, FABP12, NPPB, SAA4, THBD
9vegf4411.9ADM, MB, NPPA, PIK3C2A, CRP, CHKB
10arginine4411.9CHKB, PIK3C2A, AHSP, THBD, ADM, NPPB
11homocysteine44 2412.9SAA4, ADM, SELP, THBD, PLAT, NPPB
12fibrinogen4411.9CRP, CHKB, AHSP, SAA4, THBD, SERPINF2
13losartan44 49 28 1114.8NPPB, ACE, NPPA, CRP, PLAT, ADM
14sodium nitroprusside4411.8AHSP, PIK3C2A, NPPA, NPPB, MB, ADM
15aspirin44 49 28 2414.8NPPB, CHKB, SELP, ACE, THBD, PLAT
16epinephrine44 11 2413.8SERPINF2, SELP, CHKB, PIK3C2A, MB, NPPA
17fluvastatin44 49 28 1114.7CRP, CHKB, MB, THBD, SELP, PLAT
18atorvastatin44 49 28 11 2415.7PIK3C2A, NPPB, CRP, CHKB, PLAT, THBD
19citrate4411.6SELP, MB, PIK3C2A, CRP, CHKB, FABP3
20thyroxine44 2412.6PLAT, THBD, SERPINF2, PIK3C2A, NPPB, MB
21cyclosporin a44 28 5913.6NPPA, PIK3C2A, NPPB, ADM, THBD, PLAT
22perindopril44 49 1113.6THBD, PLAT, CRP, NPPA, NPPB, ACE
23fatty acid4411.6TNNT2, THBD, NPPB, FABP12, CHKB, ADM
24heparin44 28 11 2414.6CHKB, SELP, MB, TNNT2, PIK3C2A, AHSP
25thromboxane44 2412.5SELP, THBD, PLAT, PIK3C2A, SERPINF2, AHSP
26kininogen4411.5SERPINF2, PLAT, ACE, THBD, SELP, NPPA
27prostaglandin f2alpha4411.5AHSP, CRP, FABP12, MB, SAA4, ADM
28pravastatin44 49 28 11 2415.5NPPB, PIK3C2A, CRP, CHKB, THBD, SELP
29norepinephrine44 11 2413.5CHKB, AHSP, ADM, FABP3, MB
30aprotinin44 1112.5SERPINF2, SELP, THBD, PLAT, MB, NPPB
31quinapril44 1112.4SELP, ACE, PLAT, CRP, NPPA
32endotoxin4411.4SAA4, CHKB, AHSP, THBD, ADM
33desmopressin44 59 28 1114.3NPPA, PLAT, THBD, SELP, SERPINF2
34clopidogrel49 44 11 2414.3PLAT, ACE, SELP, CHKB, CRP
35spec-t4411.3ADM, PLAT, CHKB, NPPA, NPPB
36mibg4411.3ADM, NPPB, FABP3, NPPA
37thallium4411.3NPPB, PIK3C2A, FABP3, CHKB
38prednisolone44 28 1113.3NPPB, MB, CRP, THBD, CHKB, PIK3C2A
39hirudin4411.3PLAT, SERPINF2, SELP, PIK3C2A, THBD
40uric acid44 2412.2SAA4, NPPB, CHKB, PIK3C2A
41omapatrilat4411.2ADM, ACE, PLAT, NPPA
42dobutamine44 28 1113.2PLAT, CHKB, NPPA, NPPB
43nitric oxide44 11 2413.2SELP, AHSP, NPPB, NPPA, CHKB, THBD
44fosinopril44 1112.1NPPB, NPPA, CRP, ACE
45simvastatin44 49 59 28 11 2416.1PLAT, SELP, CHKB, CRP, PIK3C2A, THBD
46enalaprilat4411.0NPPB, NPPA, PLAT, ACE
47ramipril44 1111.9ACE, NPPA, NPPB, CRP
48mannitol44 1111.9MB, CRP
49captopril44 28 49 59 1114.8ADM, AHSP
50warfarin44 49 11 2413.6SELP, PIK3C2A

GO Terms for genes affiliated with Acute Myocardial Infarction

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16Gene Ontology
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Cellular components related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.4ADM, SERPINF2, SELP, ACE, PLAT, CRP
2extracellular regionGO:00557611.3ADM, SAA4, SERPINF2, PTX3, ACE, PLAT
3troponin complexGO:00586110.7TNNI3, TNNT2

Biological processes related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00166611.2ADM, MB, CRP, PLAT
2acute-phase responseGO:00695311.1SERPINF2, SAA4, CRP
3response to insulin stimulusGO:03286811.0NPPA, FABP3, ADM
4regulation of blood pressureGO:00821711.0NPPB, NPPA, ACE
5female pregnancyGO:00756510.9ADM, THBD, NPPA
6opsonizationGO:00822810.9CRP, PTX3
7negative regulation of ATPase activityGO:03278010.8TNNT2, TNNI3
8cGMP biosynthetic processGO:00618210.8NPPA, NPPB
9regulation of blood vessel sizeGO:05088010.7NPPA, NPPB
10negative regulation of fibrinolysisGO:05191810.7SERPINF2, THBD
11regulation of vasodilationGO:04231210.6ACE, NPPB
12receptor guanylyl cyclase signaling pathwayGO:00716810.4NPPB, NPPA

Molecular functions related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8ADM, NPPA, NPPB
2troponin C bindingGO:03017210.4TNNI3, TNNT2

Products for genes affiliated with Acute Myocardial Infarction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Myocardial Infarction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet