MCID: ACT075
MIFTS: 59

Acute Myocardial Infarction malady

Genetic diseases (common), Cardiovascular diseases categories

Summaries for Acute Myocardial Infarction

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34MalaCards
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MalaCards: Acute Myocardial Infarction is related to myocardial infarction and cardiogenic shock. An important gene associated with Acute Myocardial Infarction is NPPA (natriuretic peptide A), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and A-beta Plaque Formation and APP Metabolism. The compounds dobutamine and enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are behavior/neurological and muscle.

Aliases & Classifications for Acute Myocardial Infarction

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

acute myocardial infarction 9 46 63


External Ids:

Disease Ontology9 DOID:9408
ICD9CM28 410.90, 410, 410.9
NCIt41 C35204
ICD1026 I21

Related Diseases for Acute Myocardial Infarction

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Myocardial Infarction family:

Posterior Myocardial Infarction acute myocardial infarction
Myocardial Infarction, Susceptibility to, 1 Myocardial Infarction 2

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction31.9FABP12, FABP3, SAA4, F3, ACE, PLAT
2cardiogenic shock31.7PIK3C2A, PLAT, NPPB
3cardiac rupture31.6PLAT, CHKB
4coronary thrombosis31.3PLAT, F3
5myocarditis31.2NPPB, MB, CHKB, TNNI3, TNNT2
6diabetes mellitus31.1PIK3C2A, ACE, PLAT, CRP, NPPA, NPPB
7hypertension31.0ADM, ACE, PLAT, CRP, NPPA, NPPB
8congestive heart failure30.9TNNT2, TNNI3
9obesity30.8SULT1A3, FABP12, FABP3, SAA4, CRP
10coronary artery vasospasm30.8AHSP, CHKB
11coronary artery disease30.8CRP, MB, NPPA, NPPB, CTF1, PLAT
12kawasaki disease30.7ADM, CRP, NPPB
13ischemia30.7PIK3C2A, AHSP, TNNT2, CTF1, NPPB, MB
14thrombophilia30.7PLAT, F3, SERPINF2
15thrombocytosis30.7SERPINF2, F3, CRP
16hypercholesterolemia30.6AHSP, SERPINF2, ACE, CRP
17antiphospholipid syndrome30.6PLAT, F3, SULT1A3
18pneumonia30.6PIK3C2A, ADM, SAA4, CRP, MB
19atrioventricular block30.6PIK3C2A, NPPB
20insulin resistance30.5FABP12, FABP3, ACE, PLAT, CRP, MB
21intermediate coronary syndrome30.5PIK3C2A, TNNT2, TNNI3, PLAT, MB
22atherosclerosis30.4SULT1A3, SERPINF2, PTX3, AHSP, FABP12, SAA4
23vasculitis30.4PTX3, SULT1A3, CRP
24sick sinus syndrome30.4NPPA
25syndrome of inappropriate antidiuretic hormone30.4NPPA, NPPB
26disseminated intravascular coagulation30.4PIK3C2A, SERPINF2, F3, PLAT, MB
27thromboembolism30.4SERPINF2, SULT1A3, F3, PLAT
28pericardial effusion30.4CHKB, PIK3C2A
29status asthmaticus30.3PIK3C2A
30neuroleptic malignant syndrome30.3PIK3C2A, CHKB, MB
31peripheral vascular disease30.3PLAT, F3
32polymyositis30.3PIK3C2A, CHKB, MB
33septic shock30.3PIK3C2A, PTX3, ADM, F3, CRP, NPPB
34respiratory failure30.3PIK3C2A, F3, CRP
35type 2 diabetes mellitus30.3SERPINF2, ADM, FABP12, ACE, PLAT, CRP
36acute pancreatitis30.3SULT1A3, CRP, MB
37arthritis30.2SULT1A3, SAA4, CRP, MB
38proteinuria30.2CRP, ACE, SAA4, ADM, PIK3C2A
39rheumatoid arthritis30.2MB, CRP, SAA4, CHKB, PTX3
40pulmonary embolism30.2SERPINF2, FABP3, F3, PLAT, NPPB
41vascular disease30.1CRP, PLAT, ACE, F3, SULT1A3, AHSP
42cerebrovascular disease30.1SULT1A3, ADM, FABP12, FABP3, SAA4, F3
43endotheliitis11.0
44aneurysm10.9
45angina pectoris10.9
46myocardial infarction 210.8
47right bundle branch block10.8
48artery disease10.8
49blindness10.8
50spontaneous coronary artery dissection10.8

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to acute myocardial infarction

Symptoms for Acute Myocardial Infarction

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Drugs & Therapeutics for Acute Myocardial Infarction

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Acute Myocardial Infarction

Drug clinical trials:

Search ClinicalTrials for Acute Myocardial Infarction

Search NIH Clinical Center for Acute Myocardial Infarction

Search CenterWatch for Acute Myocardial Infarction

Genetic Tests for Acute Myocardial Infarction

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Anatomical Context for Acute Myocardial Infarction

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34MalaCards
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MalaCards organs/tissues related to Acute Myocardial Infarction:

34
Heart, Endothelial, Brain, Monocytes, Testes, Bone, Bone marrow, Prostate, Thyroid, Whole blood, Kidney, Lung, Liver, Skeletal muscle, Myeloid, Small intestine, Spinal cord, T cells, Spleen, Pituitary

Animal Models for Acute Myocardial Infarction or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Acute Myocardial Infarction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2ADM, TNNI3, CHKB, FABP3, F3, ACE
2MP:00053698.1ADM, TNNT2, CHKB, F3, PLAT, MB
3MP:00053848.0AHSP, PTX3, ADM, F3, ACE, MB
4MP:00053857.8TNNT2, TNNI3, ADM, FABP3, NPPB, NPPA
5MP:00053977.5AHSP, PTX3, ADM, F3, ACE, PLAT
6MP:00107687.4PIK3C2A, AHSP, TNNT2, TNNI3, ADM, FABP3
7MP:00053877.3AHSP, PTX3, ADM, F3, PIK3C2A, CRP
8MP:00053766.8MB, CTF1, NPPA, CRP, PLAT, PIK3C2A

Publications for Acute Myocardial Infarction

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Sources:
53PubMed
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Articles related to Acute Myocardial Infarction:

(show top 50)    (show all 2449)
idTitleAuthorsYear
1
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
2
The Relationship of Acute Myocardial Infarction With or Without ST-Segment Elevation and Viscosity. (23742945)
2013
3
Endoscopy after acute myocardial infarction: an evaluation of safety. (24096947)
2013
4
Comparison of cancer risk associated with low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction in women versus men. (23972348)
2013
5
Validity of the GRACE score for 6-month death or reinfarction after presentation with acute myocardial infarction in patients 80 years of age and older. (23965947)
2013
6
Acute myocardial infarction in patients with chronic kidney disease: how are the most vulnerable patients doing? (23903416)
2013
7
Cardiovascular outcomes using intra-aortic balloon pump in high-risk acute myocardial infarction with or without cardiogenic shock: a meta-analysis. (21335478)
2012
8
Association of platelet collagen receptor polymorphisms with premature acute myocardial infarction. (22627583)
2012
9
Diagnostic performance of high-sensitivity troponin T, myeloperoxidase, and pregnancy-associated plasma protein A assays for triage of patients with acute myocardial infarction. (21779191)
2011
10
Appraisal of the prognosis in patients with acute myocardial infarction treated with primary percutaneous coronary intervention. (19568720)
2009
11
The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. (19637097)
2009
12
Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients. (19540141)
2009
13
Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. (18997620)
2009
14
Enhanced proinflammatory response of mononuclear cells to in vitro LPS-challenge in patients with ventricular fibrillation in the setting of acute myocardial infarction. (18571935)
2008
15
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments. (17726257)
2007
16
Dynamics and source of endothelin-1 and interleukin-6 following coronary reperfusion in patients with acute myocardial infarction. (17507790)
2007
17
Glomerular filtration rate on admission independently predicts short-term in-hospital mortality after acute myocardial infarction. (16926535)
2006
18
Relationship between the mismatch of 123I-BMIPP and 201Tl myocardial single-photon emission computed tomography and autonomic nervous system activity in patients with acute myocardial infarction. (16607047)
2006
19
On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease. (16251892)
2006
20
Kinetics of chemokines in acute myocardial infarction. (15928736)
2005
21
Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy. (14965340)
2004
22
Noninvasive estimation of impaired hemodynamics for patients with acute myocardial infarction by Tei index. (15163931)
2004
23
The pro- and anti-inflammatory markers in patients with acute myocardial infarction and chronic stable angina. (15254785)
2004
24
Acute myocardial infarction probably caused by paradoxical embolus in a pregnant woman. (14966073)
2004
25
Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. (12520145)
2003
26
Pleiotropic effects of cytokines on acute myocardial infarction: G-CSF as a novel therapy for acute myocardial infarction. (12769752)
2003
27
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
28
Acute myocardial infarction: a rare complication of protein C deficiency. (11294179)
2001
29
Soluble P-selectin and the success of thrombolysis in acute myocardial infarction. (11461745)
2001
30
Biochemical markers in the management of suspected acute myocardial infarction in the emergency department. (11310455)
2001
31
Survival outcomes 1 year after reperfusion therapy with either alteplase or reteplase for acute myocardial infarction: results from the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO) III Trial. (11023929)
2000
32
Intracranial hemorrhage rates and effect of immediate beta-blocker use in patients with acute myocardial infarction treated with tissue plasminogen activator. Participants in the National Registry of Myocardial Infarction-2. (11078295)
2000
33
Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction. (10816061)
2000
34
Prehospital management of acute myocardial infarction: Electrocardiogram acquisition and interpretation, and thrombolysis by prehospital care providers. (9852937)
1998
35
Plasma levels of adrenomedullin in patients with acute myocardial infarction. (9536921)
1998
36
Elevated plasma levels of interleukin-1 receptor antagonist and interleukin-10 in patients with acute myocardial infarction. (9085939)
1997
37
Effects of ramipril and spironolactone on ventricular remodeling after acute myocardial infarction: randomized and double-blind study]. (9515282)
1997
38
Captopril reduced plasminogen activator inhibitor activity in patients with acute myocardial infarction. (9152782)
1997
39
Evolution of haptoglobin concentration in serum during the early phase of acute myocardial infarction. (9056748)
1997
40
Myoglobin, creatine kinase MB, and cardiac troponin-I to assess reperfusion after thrombolysis for acute myocardial infarction: results from TIMI 10A. (9351728)
1997
41
The prognostic value of predischarge quantitative two-dimensional echocardiographic measurements and the effects of early lisinopril treatment on left ventricular structure and function after acute myocardial infarction in the GISSI-3 Trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. (8922912)
1996
42
Clinical benefit of angiotensin converting enzyme inhibition after acute myocardial infarction: myocardial reperfusion revisited. (9023710)
1996
43
Brazilian study with alteplase in acute myocardial infarction--EBRALT]. (8554497)
1995
44
Urinary albumin excretion increases during an acute myocardial infarct especially in patients who develop heart failure]. (7498633)
1995
45
The use of myoglobin for the early diagnosis of reperfusion in acute myocardial infarct]. (8087811)
1994
46
Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors. (8429112)
1993
47
Cardiac rupture, a clinically predictable complication of acute myocardial infarction: report of 70 cases with clinicopathologic correlations. (8354804)
1993
48
Atrial natriuretic peptide in congestive heart failure after acute myocardial infarction. (8519004)
1993
49
The risk of stroke in patients with acute myocardial infarction after thrombolytic and antithrombotic treatment. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico II (GISSI-2), and The International Study Group. (1598096)
1992
50
Serum elastinolytic activity and blood lipids in various clinical forms of arteriosclerosis and in acute myocardial infarct]. (2047114)
1991

Variations for Acute Myocardial Infarction

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Expression for genes affiliated with Acute Myocardial Infarction

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myocardial Infarction

Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for genes affiliated with Acute Myocardial Infarction

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Sources:
51PathCards, 54QIAGEN, 55R&D Systems, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1NPPB, NPPA
210.0PLAT, ACE
39.9SERPINF2, PLAT
49.8CTF1, NPPB, NPPA
5
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.7TNNT2, TNNI3, ACE
6
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.5SERPINF2, F3, PLAT
7
Show member pathways
9.5PLAT, F3, SERPINF2
8
Show member pathways
thioredoxin pathway39
9.5CRP, PLAT, SAA4

Compounds for genes affiliated with Acute Myocardial Infarction

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1dobutamine46 30 52 1213.0PLAT, NPPA, NPPB, CHKB
2enalaprilat469.9ACE, PLAT, NPPA, NPPB
3fosinopril46 1210.9NPPB, NPPA, CRP, ACE
4quinapril46 52 1211.9CRP, ACE, PLAT, NPPA
5omapatrilat469.8ADM, ACE, PLAT, NPPA
6perindopril46 52 1211.7ACE, PLAT, CRP, NPPA, NPPB
7ramipril46 1210.7ACE, CRP, NPPA, NPPB
8spec-t469.6ADM, CHKB, PLAT, NPPA, NPPB
9thallium469.6PIK3C2A, NPPB, FABP3, CHKB
10clopidogrel46 52 25 1212.6CHKB, F3, ACE, PLAT, CRP
11tirofiban46 1210.6NPPB, CRP, PLAT, F3
128-bromo cgmp469.4ADM, NPPA, AHSP, NPPB
13losartan46 52 30 1212.3ADM, NPPB, NPPA, CRP, ACE, PLAT
14kininogen469.3PLAT, SERPINF2, ACE, F3, NPPA
15mibg469.3NPPA, ADM, PIK3C2A, FABP3, NPPB
16captopril46 62 52 30 1213.2F3, AHSP, ADM, ACE, NPPB, NPPA
17fluvastatin46 52 30 1212.1ACE, MB, CRP, PIK3C2A, CHKB, PLAT
18atorvastatin46 52 30 25 1213.1PIK3C2A, NPPB, CRP, ACE, PLAT, CHKB
19aprotinin46 1210.0PLAT, NPPB, F3, SERPINF2, MB
20citrate468.9FABP3, F3, CRP, MB, CHKB, PIK3C2A
21pravastatin46 52 30 25 1212.9ACE, CRP, CHKB, PIK3C2A, NPPB
22thyroxine46 259.8PIK3C2A, CHKB, PLAT, MB, NPPB, SERPINF2
23catecholamine468.8NPPA, CHKB, PIK3C2A, SULT1A3, ADM, NPPB
24isoproterenol46 129.7PLAT, NPPA, NPPB, PIK3C2A, AHSP, ADM
25sodium nitroprusside468.7ADM, NPPB, PIK3C2A, NPPA, MB, PLAT
26aspirin46 52 30 2511.6ACE, CHKB, SULT1A3, AHSP, PLAT, CRP
27acetylcholine46 52 30 25 1212.5NPPB, MB, AHSP, PIK3C2A, ADM, ACE
28endotoxin468.4AHSP, F3, SERPINF2, ADM, CHKB, SAA4
29prostaglandin f2alpha468.4ADM, FABP12, CRP, MB, SAA4, AHSP
30potassium46 25 1210.3NPPA, CHKB, ADM, TNNI3, PIK3C2A, ACE
31uric acid46 259.2CHKB, FABP12, NPPB, CRP, SAA4, PIK3C2A
32prostacyclin468.1NPPB, NPPA, CRP, PLAT, ACE, F3
33testosterone46 62 25 1211.0MB, NPPB, NPPA, CRP, CHKB, ADM
34vegf468.0CHKB, F3, CRP, MB, PIK3C2A, SERPINF2
35nitroglycerin46 128.9PLAT, CRP, NPPA, NPPB, ACE, F3
36epinephrine46 25 129.9ADM, SERPINF2, PIK3C2A, CHKB, F3, SULT1A3
37arginine467.8PIK3C2A, SERPINF2, NPPA, MB, CHKB, ADM
38ptca467.8PIK3C2A, TNNT2, SERPINF2, ADM, CHKB, SAA4
39heparin46 30 25 1210.6NPPB, SULT1A3, F3, MB, CHKB, SERPINF2
40norepinephrine46 25 129.6ACE, PIK3C2A, SULT1A3, ADM, CHKB, FABP3
41homocysteine46 258.6PIK3C2A, AHSP, SULT1A3, ADM, SAA4, F3
42fibrinogen467.6AHSP, SERPINF2, CHKB, SAA4, F3, PLAT
43fatty acid467.5CHKB, FABP12, ADM, NPPB, FABP3, PIK3C2A
44lactate467.4MB, FABP12, PIK3C2A, FABP3, CRP, NPPB
45alanine467.3SERPINF2, PIK3C2A, TNNT2, CHKB, F3, MB
46glucose466.9CRP, PIK3C2A, AHSP, ADM, NPPB, PLAT
47lipid466.4NPPB, CRP, ACE, SAA4, FABP12, ADM
48calcium46 52 25 129.4TNNI3, CRP, PIK3C2A, AHSP, SERPINF2, FABP12
49cholesterol46 30 25 128.8PIK3C2A, AHSP, PTX3, FABP3, CRP, PLAT
50creatinine465.0PIK3C2A, CRP, MB, NPPA, NPPB, PLAT

GO Terms for genes affiliated with Acute Myocardial Infarction

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17Gene Ontology
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Cellular components related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.9TNNI3, TNNT2
2extracellular spaceGO:0056157.6SERPINF2, ADM, F3, ACE, PLAT, CRP
3extracellular regionGO:0055767.1CTF1, PTX3, SERPINF2, ADM, SAA4, ACE

Biological processes related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.2NPPB, NPPA
2negative regulation of ATPase activityGO:03278010.1TNNT2, TNNI3
3regulation of vasodilationGO:04231210.1NPPB, ACE
4receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB
5regulation of blood pressureGO:00821710.0NPPB, NPPA, ACE
6regulation of blood vessel sizeGO:05088010.0NPPB, NPPA
7response to insulinGO:0328689.9NPPA, FABP3, ADM
8opsonizationGO:0082289.8CRP, PTX3
9heart developmentGO:0075079.6MB, ADM, TNNI3
10fibrinolysisGO:0427309.6PLAT, SERPINF2
11acute-phase responseGO:0069539.5SERPINF2, SAA4, CRP
12response to hypoxiaGO:0016669.5NPPA, MB, CRP, PLAT, ADM

Molecular functions related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7NPPB, NPPA, ADM
2troponin C bindingGO:0301729.6TNNI3, TNNT2

Products for genes affiliated with Acute Myocardial Infarction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Myocardial Infarction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet