MCID: ACT075
MIFTS: 59

Acute Myocardial Infarction malady

Cardiovascular category

Summaries for Acute Myocardial Infarction

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Acute Myocardial Infarction is related to cardiogenic shock and cardiac rupture. An important gene associated with Acute Myocardial Infarction is NPPA (natriuretic peptide A), and among its related pathways are Selenium Pathway and Complement and coagulation cascades. The compounds creatinine and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Acute Myocardial Infarction

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

acute myocardial infarction 8 45 61


External Ids:

Disease Ontology8 DOID:9408
ICD9CM27 410, 410.9, 410.90
NCIt40 C35204
ICD1025 I21

Related Diseases for Acute Myocardial Infarction

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the myocardial infarction family:

posterior myocardial infarction acute myocardial infarction
myocardial infarction, susceptibility to, 1 myocardial infarction 2

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 317)
idRelated DiseaseScoreTop Affiliating Genes
1cardiogenic shock31.6NPPB, PIK3C2A, PLAT
2cardiac rupture31.4PLAT, CHKB
3coronary artery disease,31.1SAA4, MB, NPPB, NPPA, PIK3C2A, CRP
4coronary heart disease30.9AHSP, PLAT, THBD, ACE, SELP, SERPINF2
5atherosclerosis30.9SERPINF2, SELP, SAA4, MB, FABP12, CRP
6stroke, ischemic30.8SELP, THBD, PLAT
7hyperhomocysteinemia30.8SELP, THBD, PLAT, CRP
8coronary artery vasospasm30.7CHKB, AHSP
9ventricular septal defect30.7TNNI3
10hypercholesterolemia30.6CRP, AHSP, THBD, ACE, SELP, SERPINF2
11thrombophilia30.6PLAT, THBD, SELP, SERPINF2
12thrombocytosis30.6SERPINF2, SELP, THBD, CRP
13kawasaki disease30.6NPPB, CRP, ADM
14thrombocytopenia30.6SELP, THBD, PIK3C2A
15antiphospholipid syndrome30.6SELP, THBD, PLAT
16systemic lupus erythematosus30.6CRP
17insulin resistance30.5MB, FABP12, FABP3, CRP, PLAT, ACE
18hyperuricemia30.5PIK3C2A
19septic shock30.4NPPB, PIK3C2A, CRP, THBD, PTX3, ADM
20intermediate coronary syndrome30.4MB, TNNT2, TNNI3, PIK3C2A, PLAT
21thromboembolism30.4SERPINF2, SELP, THBD, PLAT
22vasculitis30.4SELP, PTX3, THBD, CRP
23arteriosclerosis30.4ADM, AHSP
24pheochromocytoma30.4ADM, NPPA
25sleep disorder30.4CHKB
26atrioventricular block30.4PIK3C2A, NPPB
27vascular disease30.2CRP, AHSP, PLAT, THBD, ACE, SELP
28pulmonary disease, chronic obstructive30.2MB, NPPB, CRP, AHSP
29arthritis30.2SAA4, MB, CRP
30neuroleptic malignant syndrome30.2MB, PIK3C2A, CHKB
31polymyositis30.2CHKB, PIK3C2A, MB
32hypertrophic cardiomyopathy30.2TNNT2, TNNI3
33acute pancreatitis30.2CRP, MB
34polycythemia vera30.2THBD, SELP
35asthma30.2CHKB, ADM
36sick sinus syndrome30.2NPPA
37peripheral vascular disease30.2ACE, SELP
38coronary aneurysm10.9
39angina pectoris10.8
40coronary thrombosis10.8
41myocardial infarction 210.8
42coronary artery aneurysm10.7
43spontaneous coronary artery dissection10.7
44acute myocarditis10.7
45myocardial infarction, decreased10.7
46septal myocardial infarction10.6
47dextrocardia10.6
48aneurysm disease10.6
49left ventricular outflow tract obstruction10.5
50essential thrombocythemia10.5

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to acute myocardial infarction

Clinical Features for Acute Myocardial Infarction

Drugs & Therapeutics for Acute Myocardial Infarction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Myocardial Infarction

Drug clinical trials:

Search ClinicalTrials for Acute Myocardial Infarction

Search NIH Clinical Center for Acute Myocardial Infarction

Search CenterWatch for Acute Myocardial Infarction

Genetic Tests for Acute Myocardial Infarction

Anatomical Context for Acute Myocardial Infarction

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acute Myocardial Infarction:

33
Liver, Spinal cord, Brain, Kidney, Lung, Spleen, Bone marrow, Whole blood, Heart, Skeletal muscle, Small intestine, Thyroid, Prostate, Myeloid, Monocytes, T cells, B cells, Endothelial, Atrioventricular node, Pituitary

Animal Models for Acute Myocardial Infarction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acute Myocardial Infarction

Sources:
51PubMed
See all sources

Articles related to Acute Myocardial Infarction:

(show top 50)    (show all 2930)
idTitleAuthorsYear
1
Diagnosis of acute myocardial infarction on computed tomography angiogram. (24421363)
2014
2
Reperfusion therapy of acute ischaemic stroke and acute myocardial infarction: similarities and differences. (24096325)
2014
3
Response to Letter Regarding Article, a89Galectin-3 and Cardiac Function in Survivors of Acute Myocardial Infarctiona89. (24027781)
2013
4
Predictive value of lipoprotein indices for residual risk of acute myocardial infarction and sudden death in men with low-density lipoprotein cholesterol levels <120 mg/dl. (23831165)
2013
5
Clinical characteristics of silent myocardial ischemia diagnosed with adenosine stress 99mTc-tetrofosmin myocardial scintigraphy in Japanese patients with acute cerebral infarction. (22124530)
2013
6
Association between Admission Hyperglycemia During Hospitalization for Acute Myocardial Infarction and Subsequent Diabetes: Insights from the Veterans Administration Cardiac Care Follow-up Clinical Study. (24089537)
2013
7
A Pharmacokinetic and Pharmacodynamic Comparison of Immediate-Release Metoprolol and Extended-Release Metoprolol CR/XL in Patients with Suspected Acute Myocardial Infarction: A Randomized, Open-Label Study. (24247812)
2013
8
The chronergy of recombinant streptokinase thrombolysis in acute myocardial infarction. (23737880)
2013
9
Plasma dimethylglycine and risk of incident acute myocardial infarction in patients with stable angina pectoris. (23723367)
2013
10
A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction. (24046434)
2013
11
The China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE) retrospective study of acute myocardial infarction: study design. (24221838)
2013
12
A Case of Acute Myocardial Infarction With ST-Segment Elevation in a Lead Augmented Right Vector Caused by a Left Main Coronary Artery Vasospasm. (22363384)
2012
13
Interpretation of acute myocardial infarction with persistent 'hyperacute T waves' by cardiac magnetic resonance. (24062926)
2012
14
A successfully thrombolysed acute inferior myocardial infarction due to type A aortic dissection with lethal consequences: the importance of early cardiac echocardiography. (21864356)
2011
15
Insulin-like growth factor binding protein-1 is a long-term predictor of heart failure in survivors of a first acute myocardial infarction and population controls. (18793810)
2010
16
Primary angioplasty versus fibrinolysis in acute myocardial infarction: long-term follow-up in the Danish acute myocardial infarction 2 trial. (20308618)
2010
17
Effect of acute myocardial infarction on erythrocytic glutathione peroxidase 1 activity and plasma vitamin e levels. (19195504)
2009
18
Post-reperfusion lymphopenia and microvascular obstruction in ST-segment elevation acute myocardial infarction. (19793516)
2009
19
High degree Atrioventricular block in patients with acute inferior Myocardial Infarction with and without Right Ventricular involvement. (19409156)
2009
20
The expression of TNF-alpha converting enzyme at the site of ruptured plaques in patients with acute myocardial infarction. (18226043)
2008
21
Facilitated PCI by combination fibrinolysis or upstream tirofiban in acute ST-segment elevation myocardial infarction: results of the Alteplase and Tirofiban in Acute Myocardial Infarction (ATAMI) trial. (18055037)
2008
22
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments. (17726257)
2007
23
Timing of ischemic onset estimated from the electrocardiogram is better than historical timing for predicting outcome after reperfusion therapy for acute anterior myocardial infarction: a DANish trial in Acute Myocardial Infarction 2 (DANAMI-2) substudy. (17584552)
2007
24
Preliminary experience with intravenous P2Y12 platelet receptor inhibition as an adjunct to reduced-dose alteplase during acute myocardial infarction: results of the Safety, Tolerability and Effect on Patency in Acute Myocardial Infarction (STEP-AMI) angiographic trial. (17892995)
2007
25
Left ventricular remodeling and systolic deterioration in acute myocardial infarction: findings from the Stent-PAMI Study. (16115154)
2005
26
Systemic inflammation and reperfusion injury in patients with acute myocardial infarction. (16489260)
2005
27
Mortality rates in elderly patients who take different angiotensin-converting enzyme inhibitors after acute myocardial infarction: a class effect? (15262665)
2004
28
Pathobiology, not angiography, should guide management in acute coronary syndrome/non-ST-segment elevation myocardial infarction: the non-interventionist's perspective. (12644348)
2003
29
A propensity score-matched cohort study of the effect of statins, mainly fluvastatin, on the occurrence of acute myocardial infarction. (14675584)
2003
30
Increased plasma thioredoxin in patients with acute myocardial infarction. (14677813)
2003
31
Integrating cost-effectiveness evidence into clinical practice guidelines in Australia for acute myocardial infarction. (15609115)
2002
32
Drug treatment of elderly patients with acute myocardial infarction: practical recommendations. (11772121)
2001
33
Adhesion molecules in different treatments of acute myocardial infarction. (11353931)
2001
34
Increased plasma glutathione peroxidase activity in patients with acute myocardial infarction. (11386018)
2001
35
Early neurohormonal effects of trandolapril in patients with left ventricular dysfunction and a recent acute myocardial infarction: a double-blind, randomized, placebo-controlled multicentre study. (11163738)
2001
36
Payer status and the utilization of hospital resources in acute myocardial infarction: a report from the National Registry of Myocardial Infarction 2. (10737281)
2000
37
A prospective study of an algorithm using cardiac troponin I and myoglobin as adjuncts in the diagnosis of acute myocardial infarction and intermediate coronary syndromes in a veteran's hospital. (11129678)
2000
38
Cytokines and adhesion molecules in the course of acute myocardial infarction. (10090530)
1999
39
Newer thrombolytic drugs for acute myocardial infarction. (9536645)
1998
40
Rebound increase of plasminogen activator inhibitor type I after cessation of thrombolytic treatment for acute myocardial infarction is independent of type of plasminogen activator used. (9474013)
1998
41
Elevated plasma levels of interleukin-1 receptor antagonist and interleukin-10 in patients with acute myocardial infarction. (9085939)
1997
42
Effects of ramipril and spironolactone on ventricular remodeling after acute myocardial infarction: randomized and double-blind study]. (9515282)
1997
43
Evolution of haptoglobin concentration in serum during the early phase of acute myocardial infarction. (9056748)
1997
44
Recombinant hirudin and front-loaded alteplase in acute myocardial infarction: final results of a pilot study. HIT-I (hirudin for the improvement of thrombolysis). (8542868)
1995
45
Prognostic significance of right ventricular dysfunction in patients with acute inferior myocardial infarction and right ventricular involvement. (7788946)
1995
46
Reperfusion reduces left ventricular dilatation by preventing infarct expansion in the acute and chronic phases of myocardial infarction. (8122595)
1994
47
Enalaprilat in acute myocardial infarction: tolerability and effects on the renin-angiotensin system. (1657799)
1991
48
Patterns of maximal spatial ST vector of S-T segment elevation in the right praecordial leads of the electrocardiogram in patients with acute inferior myocardial infarction. (3229436)
1988
49
Second-degree type I atrioventricular block in a patient with acute posteroinferior myocardial infarction and syncopal attacks. (3775211)
1986
50
Complete right bundle branch block and acute myocardial infarction an ominous sign. (748487)
1978

Genetic Variations for Acute Myocardial Infarction

Expression for genes affiliated with Acute Myocardial Infarction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Myocardial Infarction

Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for genes affiliated with Acute Myocardial Infarction

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 53R&D Systems
See all sources

Pathways related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8PLAT, CRP, SAA4
2
Hide members
10.8PLAT, THBD, SERPINF2
3
Hide members
10.8SERPINF2, THBD, PLAT
4
Hide members
10.8SERPINF2, SELP, THBD
510.7SERPINF2, PLAT

Compounds for genes affiliated with Acute Myocardial Infarction

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1creatinine4512.8CHKB, PIK3C2A, FABP3, FABP12, SAA4, MB
2cholesterol45 29 11 2415.5SAA4, FABP12, FABP3, PIK3C2A, CRP, CHKB
3lactate4512.2PIK3C2A, MB, TNNT2, TNNI3, ADM, SELP
4glucose4512.2PIK3C2A, FABP3, FABP12, NPPB, CRP, SAA4
5ptca4512.0CHKB, PLAT, THBD, SELP, SERPINF2, ADM
6nitroglycerin45 1113.0CRP, ADM, SELP, ACE, PLAT, AHSP
7prostacyclin4512.0NPPB, PIK3C2A, CRP, AHSP, PLAT, THBD
8lipid4512.0ACE, PIK3C2A, FABP12, NPPB, SAA4, THBD
9vegf4511.9ADM, MB, NPPA, PIK3C2A, CRP, CHKB
10arginine4511.9CHKB, PIK3C2A, AHSP, THBD, ADM, NPPB
11homocysteine45 2412.9SAA4, ADM, SELP, THBD, PLAT, NPPB
12fibrinogen4511.9CRP, CHKB, AHSP, SAA4, THBD, SERPINF2
13losartan45 50 29 1114.8NPPB, ACE, NPPA, CRP, PLAT, ADM
14sodium nitroprusside4511.8AHSP, PIK3C2A, NPPA, NPPB, MB, ADM
15aspirin45 50 29 2414.8NPPB, CHKB, SELP, ACE, THBD, PLAT
16epinephrine45 11 2413.8SERPINF2, SELP, CHKB, PIK3C2A, MB, NPPA
17fluvastatin45 50 29 1114.7CRP, CHKB, MB, THBD, SELP, PLAT
18atorvastatin45 50 29 11 2415.7PIK3C2A, NPPB, CRP, CHKB, PLAT, THBD
19citrate4511.6SELP, MB, PIK3C2A, CRP, CHKB, FABP3
20thyroxine45 2412.6PLAT, THBD, SERPINF2, PIK3C2A, NPPB, MB
21cyclosporin a45 29 6013.6NPPA, PIK3C2A, NPPB, ADM, THBD, PLAT
22perindopril45 50 1113.6THBD, PLAT, CRP, NPPA, NPPB, ACE
23fatty acid4511.6TNNT2, THBD, NPPB, FABP12, CHKB, ADM
24heparin45 29 11 2414.6CHKB, SELP, MB, TNNT2, PIK3C2A, AHSP
25thromboxane45 2412.5SELP, THBD, PLAT, PIK3C2A, SERPINF2, AHSP
26kininogen4511.5SERPINF2, PLAT, ACE, THBD, SELP, NPPA
27prostaglandin f2alpha4511.5AHSP, CRP, FABP12, MB, SAA4, ADM
28pravastatin45 50 29 11 2415.5NPPB, PIK3C2A, CRP, CHKB, THBD, SELP
29norepinephrine45 11 2413.5CHKB, AHSP, ADM, FABP3, MB
30aprotinin45 1112.5SERPINF2, SELP, THBD, PLAT, MB, NPPB
31quinapril45 1112.4SELP, ACE, PLAT, CRP, NPPA
32endotoxin4511.4SAA4, CHKB, AHSP, THBD, ADM
33desmopressin45 60 29 1114.3NPPA, PLAT, THBD, SELP, SERPINF2
34clopidogrel50 45 11 2414.3PLAT, ACE, SELP, CHKB, CRP
35spec-t4511.3ADM, PLAT, CHKB, NPPA, NPPB
36mibg4511.3ADM, NPPB, FABP3, NPPA
37thallium4511.3NPPB, PIK3C2A, FABP3, CHKB
38prednisolone45 29 1113.3NPPB, MB, CRP, THBD, CHKB, PIK3C2A
39hirudin4511.3PLAT, SERPINF2, SELP, PIK3C2A, THBD
40uric acid45 2412.2SAA4, NPPB, CHKB, PIK3C2A
41omapatrilat4511.2ADM, ACE, PLAT, NPPA
42dobutamine45 29 1113.2PLAT, CHKB, NPPA, NPPB
43nitric oxide45 11 2413.2SELP, AHSP, NPPB, NPPA, CHKB, THBD
44fosinopril45 1112.1NPPB, NPPA, CRP, ACE
45simvastatin45 50 60 29 11 2416.1PLAT, SELP, CHKB, CRP, PIK3C2A, THBD
46enalaprilat4511.0NPPB, NPPA, PLAT, ACE
47ramipril45 1111.9ACE, NPPA, NPPB, CRP
48mannitol45 1111.9MB, CRP
49captopril45 29 50 60 1114.8ADM, AHSP
50warfarin45 50 11 2413.6SELP, PIK3C2A

GO Terms for genes affiliated with Acute Myocardial Infarction

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.4ADM, SERPINF2, SELP, ACE, PLAT, CRP
2extracellular regionGO:00557611.3ADM, SAA4, SERPINF2, PTX3, ACE, PLAT
3troponin complexGO:00586110.7TNNI3, TNNT2

Biological processes related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00166611.2ADM, PLAT, CRP, MB
2acute-phase responseGO:00695311.1SERPINF2, CRP, SAA4
3response to insulin stimulusGO:03286811.0NPPA, FABP3, ADM
4regulation of blood pressureGO:00821711.0ACE, NPPA, NPPB
5negative regulation of ATPase activityGO:03278010.9TNNT2, TNNI3
6female pregnancyGO:00756510.9ADM, THBD, NPPA
7opsonizationGO:00822810.8CRP, PTX3
8cGMP biosynthetic processGO:00618210.8NPPA, NPPB
9regulation of blood vessel sizeGO:05088010.7NPPA, NPPB
10negative regulation of fibrinolysisGO:05191810.7THBD, SERPINF2
11receptor guanylyl cyclase signaling pathwayGO:00716810.6NPPA, NPPB
12regulation of vasodilationGO:04231210.4ACE, NPPB

Molecular functions related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8ADM, NPPA, NPPB
2troponin C bindingGO:03017210.4TNNI3, TNNT2

Products for genes affiliated with Acute Myocardial Infarction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Myocardial Infarction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet