Acute Myocardial Infarction malady

MalaCards: Acute Myocardial Infarction is related to myocardial infarction and congestive heart failure. An important gene associated with Acute Myocardial Infarction is NPPA (natriuretic peptide A), and among its related pathways are Complement and coagulation cascades and Blood Coagulation Signaling Pathways. The compounds sodium and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are respiratory system and mortality/aging.

Aliases & Descriptions:

acute myocardial infarction 6 8 32 43

Diseases related to acute myocardial infarction by text searches and GeneDecks gene sharing:

(show top 50)    (show all 930)

id	Related Disease	Score	Top Affiliating Genes
1	myocardial infarction	50.9	PIK3C2A, PIK3CG, COG2, REN, RETN, CNTF
2	congestive heart failure	37.8	PIK3C2A, PIK3CG, COG2, REN, UTS2, CHRM2
3	ischemia	37.2	PIK3C2A, PIK3CG, COG2, REN, RETN, CNTF
4	thrombophilia	36.9	VWF, SELE, SELP, SERPINC1, SERPINF2, SERPIND1
5	thrombosis	36.7	PIK3C2A, PIK3CG, COG2, REN, RETN, VWF
6	ventricular fibrillation	35.9	SELP, SELPLG, SERPINE1, ZFHX3, KCNJ5, KCNJ8
7	atrial fibrillation	35.1	PIK3C2A, REN, RETN, VWF, SELE, SELP
8	coronary heart disease	34.3	PIK3C2A, COG2, RETN, KIF6, KIF2C, VWF
9	creatine phosphokinase	34.1	PIK3C2A, CKM, CHKA, CHKB, MB, GPT
10	diabetes mellitus	33.7	PIK3C2A, PIK3CG, LRP6, COG2, REN, RETN
11	blindness	33.5	PIK3C2A, PIK3CG, COG2, REN, CNTF, VWF
12	hypertension	33.4	PIK3C2A, PIK3CG, LRP6, COG2, REN, RETN
13	aldosteronism	33.3	PIK3CG, REN, RETN, SERPINE1, VIP, NAGLU
14	cholesterol	33.2	PIK3C2A, PIK3CG, LRP6, COG2, REN, RETN
15	intermediate coronary syndrome	33.0	PIK3C2A, PAPPA, ITGA2B, MB, TNNI3, TNNT2
16	heparin-induced thrombocytopenia	33.0	SELE, SELP, SERPINC1, SERPINE1, MTHFR, CD40LG
17	hepatitis	32.7	SELP, SERPINA1, XDH, CDH5, GZMB, GSR
18	cerebrovascular disease	32.6	COG2, REN, RETN, VWF, SELE, SELL
19	hemoglobinuria	32.5	PIK3C2A, VWF, SELL, SELP, MTHFR, CD14
20	homocysteine	32.3	PIK3C2A, COG2, REN, RETN, VWF, GCG
21	portal vein thrombosis	32.3	REN, SELP, SERPINC1, SERPINE1, MTHFR, JAK2
22	familial hypercholesterolemia	32.3	COG2, LPA, LPL, LIPC, LCAT, CETP
23	hyperhomocysteinemia	32.2	VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
24	factor xi deficiency	32.2	VWF, F8, F7, F5, F3, F2
25	hypercholesterolemia	32.0	PIK3C2A, COG2, RETN, VWF, GCG, SELE
26	arteriosclerosis	31.7	COG2, SELE, SELP, SERPINE1, LPA, LPL
27	autonomic dysfunction	31.6	REN, SERPINE1, MTHFR, MME, INS, IL6
28	systemic lupus erythematosus	31.5	VWF, VTN, SELE, VIP, VCAM1, BLZF1
29	obesity	31.4	PIK3C2A, PIK3CG, COG2, REN, RETN, CNTF
30	prostatitis	31.2	PIK3C2A, PIK3CG, RETN, CNTF, KITLG, KIF2C
31	periodontitis	31.0	BSG, MPO, CD36, CD14, MMP1, MMP3
32	glucose intolerance	30.9	RETN, GCG, SERPINE1, LPL, LIPC, KCNJ11
33	thrombocytopenia	30.8	PIK3C2A, KITLG, VWF, SELE, SELL, SELP
34	hypoxia	29.7	PIK3C2A, PIK3CG, REN, KITLG, VWF, VTN
35	periodontal disease	29.3	BSG, CD36, CD14, ITGB1, MMP1, MMP14
36	thyroiditis	29.3	PIK3C2A, PIK3CG, COG2, REN, RETN, KITLG
37	hypoglycemia	28.9	PIK3CG, GCG, SETD2, VEGFA, LPL, KCNJ11
38	leukemia	28.5	PIK3C2A, PIK3CG, LRP6, COG2, REN, RETN
39	lupus erythematosus	28.3	PIK3C2A, PIK3CG, COG2, RETN, CNTF, VWF
40	insulin resistance	28.3	PIK3CG, COG2, REN, RETN, CNTF, VWF
41	dementia	27.8	PIK3C2A, PIK3CG, VWF, SELP, SERPINC1, SERPINA1
42	lymphocytic leukemia	24.9	PIK3CG, KITLG, SELL, SELP, SELPLG, SERPINC1
43	cadasil	19.3	COG2, REN, RETN, CNTF, VWF, SELL
44	coronary artery anomaly	18.6	PIK3C2A, COG2, RETN, VWF, VTN, GCG
45	ischemic heart disease	17.6	PIK3C2A, COG2, RETN, SELP, SETD2, SERPINE1
46	pre-eclampsia	16.5	REN, RETN, VWF, SELE, SELL, SELP
47	pulmonary embolism	15.9	PIK3C2A, SERPINC1, SERPINF2, SERPINE1, MTHFR, MPO
48	syncope	15.9	PIK3C2A, REN, KCNJ5, SCN5A, CHKB, MTHFR
49	thromboembolism	15.8	VWF, SELP, SERPINC1, SERPINF2, SERPIND1, SERPINE1
50	venous thrombosis	15.8	VWF, SELP, SELPLG, SERPINC1, SERPINF2, SERPINE1

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

Human bone marrow-derived mesenchymal stem cells , PMIDs: NULL

MalaCards organs/tissues related to acute myocardial infarction:

²²

MGI Mouse Phenotypes related to acute myocardial infarction:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	INF	, SELL, SELP, LPL, CHRM2, CD14
2	mortality/aging	MP:0010768	INF	PIK3C2A, , REN, KITLG, VWF, GCG
3	hematopoietic system phenotype	MP:0005397	11.6	CNTF, SERPIND1, USP4, BDKRB2, LCN2, P2RY12
4	immune system phenotype	MP:0005387	11.6	REN, CNTF, VWF, SELL, SELP, SELPLG
5	endocrine/exocrine gland phenotype	MP:0005379	11.1	SELL, ZFHX3, BDKRB2, KCNJ11, XDH, CD40LG
6	other phenotype	MP:0005395	10.1	VASP, KDR, JAK2, CD40LG, ITGB1, ITGB3
7	tumorigenesis	MP:0002006	6.6	KITLG, SELL, SERPINE1, LEP, JAK2, CD34
8	normal phenotype	MP:0002873	INF	, REN, VTN, SELE, SERPING1, VIP
9	cardiovascular system phenotype	MP:0005385	INF	PIK3CG, REN, KITLG, VWF, SELE, SELL
10	vision/eye phenotype	MP:0005391	INF	, KITLG, SELE, SELP, SERPINC1, NAGLU
11	growth/size phenotype	MP:0005378	INF	PIK3C2A, PIK3CG, , REN, KITLG, GCG
12	skeleton phenotype	MP:0005390	INF	PIK3CG, , KITLG, NAGLU, VEGFA, CLEC3B
13	liver/biliary system phenotype	MP:0005370	INF	, RETN, SERPINC1, VEGFA, LPL, CHKA
14	cellular phenotype	MP:0005384	INF	PIK3CG, , CNTF, KITLG, VWF, SELE
15	nervous system phenotype	MP:0003631	INF	, REN, CNTF, KITLG, VWF, SELP
16	renal/urinary system phenotype	MP:0005367	INF	, REN, SELP, SELPLG, SERPIND1, NAGLU
17	behavior/neurological phenotype	MP:0005386	INF	, REN, CNTF, SELE, SELP, VIP
18	muscle phenotype	MP:0005369	INF	PIK3CG, REN, CNTF, SERPIND1, VEGFA, LPL
19	embryogenesis phenotype	MP:0005380	INF	, SERPINC1, SETD2, SCN5A, JUP, CDH5
20	integument phenotype	MP:0010771	INF	PIK3CG, , KITLG, SELP, SELPLG, KCNJ11
21	digestive/alimentary phenotype	MP:0005381	INF	, KITLG, VWF, GCG, VEGFA, BDKRB2
22	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PIK3CG, , REN, RETN, CNTF
23	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, , RETN, SERPINE1, LPL, BDKRB2
24	reproductive system phenotype	MP:0005389	INF	, REN, VIP, VEGFA, LIPC, BDKRB2

Articles related to acute myocardial infarction:

(show top 50)    (show all 1297)

id	Title	Authors	Year	Affiliating Genes
1	Combined determination of highly sensitive troponin T and copeptin for early exclusion of acute myocardial infarction: first experie nce in an emergency department of a general hospital. (21915168)	Lotze U.... MA1ller K.	2011	AVP
2	Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. (21677138)	Maugeri N.... Manfredi A.A.	2011	PTX3
3	Association of CD40 ligand levels in the culprit coro nary arteries with subsequent prognosis of acute myocardial infarction. (20832064)	Yoshioka T.... Momomura S.	2010	CD40LG
4	Procalcitonin as a prognostic marker in patients with acute myocardial infarction. (20214413)	Kelly D.... Ng L.L.	2010	CALCA
5	A case of acute myocardial infarction with repetitive stent thrombosis during emergent percutaneous coronary intervention. Transient decrease in antithrombin III activity and heparin resistance. (19246851)	Kaku B.... Hiraiwa Y.	2009	F2, SERPINC1
6	The relationship of plasminogen activator inhibitor-1 levels to the ST deviation pattern of acute myocardial infarction. (18580060)	Rott D.... Urieli-Shoval S.	2009	SERPINE1
7	Periostin is essential for cardiac healing after acute myocardial infarction. (18208976)	Shimazaki M.... Kudo A.	2008	PTK2, POSTN
8	Mast cell inhibition and reduced ventricular arrhythmias in a swine model of acute myocardial infarction upon therapeutic administration of relaxin. (18345514)	Nistri S.... Bani D.	2008	RLN2
9	Comparative effect of streptokinase and alteplase on electrocardiogram and angiogram signs of myocardial reperfusion in ST segment elevation acute myocardial infarction (19069338)	TomaseviA8 M.... Salinger-MartinoviA8 S.	2008	PLAT
10	Plasma N-terminal B-Type natriuretic peptide as an in dicator of long-term survival after acute myocardial infarction: comparison wit h plasma midregional pro-atrial natriuretic peptide: the LAMP (Leicester Acute Myocardial Infarction Peptide) study. (18466800)	Khan S.Q.... Ng L.L.	2008	LAMP3
11	Prognostic value of midregional pro-adrenomedullin in patients with acute myocardial infarction: the LAMP (Leicester Acute Myocardial Infarction Peptide) study. (17418290)	Khan S.Q.... Ng L.L.	2007	ADM
12	Pre-hospital detection of acute myocardial infarction with ultra-rapid human fatty acid-binding protein (H-FABP) immunoassay. (17097752)	Ecollan P.... Montalescot G.	2007	FABP3
13	C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. (17420344)	Khan S.Q.... Ng L.L.	2007	AVP, LAMP3
14	Preliminary experience with intravenous P2Y12 platelet receptor inhibition as an adjunct to reduced-dose alteplase during acute myocardial infarction: results of the Safety, Tolerability and Effect on Patency in Acute Myocardial Infarction (STEP-AMI) angiographic trial. (17892995)	Greenbaum A.B.... Weaver W.D.	2007	PLAT, SERPINC1
15	C-terminal pro-endothelin-1 offers additional prognostic information in patients after acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study. (17893002)	Khan S.Q.... Ng L.L.	2007	EDN1
16	Matrix metalloproteinase-9 is a marker of heart failure after acute myocardial infarction. (16500583)	Wagner D.R.... Beissel J.	2006	MMP2, MMP9
17	Relationship between adrenomedullin and left-ventricular systolic function and mortality in acute myocardial infarction. (15678254)	Katayama T.... Yano K.	2005	ADM
18	N-acetyl-beta-D-glucosaminidase--a marker of reperfusion and a prognostic indicator in patients with acute myocardial infarction. (16261782)	Iqbal M.P.... Mehboobali N.	2005	NAGLU
19	Exploration on the relationship between pathogenesis for yin-deficiency of acute myocardial infarction and immediate prognosis as w ell as its mechanism (15199621)	Li N.Y.... Hong C.X.	2004	NPPA
20	Strategies to increase HMG-CoA reductase inhibitor use after acute myocardial infarction. (15260513)	Muhlestein J.B.	2004	HMGCR
21	Rationale and design of a large-scale trial using atrial natriuretic peptide (ANP) as an adjunct to percutaneous coronary intervention for ST-segment elevation acute myocardial infarction: Japan-Working groups of acute myocardial infarction for the reduction of Necrotic Damage by ANP (J-WIND-ANP). (14745141)	Asakura M.... Kitakaze M.	2004	NPPA
22	Combined fibrinolysis using reduced-dose alteplase pl us abciximab with immediate rescue angioplasty versus primary angioplasty with adjunct use of abciximab for the treatment of acute myocardial infarction: Asia -Pacific Acute Myocardial Infarction Trial (APAMIT) pilot study. (15274152)	Wong A.... Lim Y.L.	2004	PLAT
23	Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. (12520145)	Mukae S.... Katagiri T.	2003	MT-ND2
24	Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)	Zebrack J.S.... Muhlestein J.B.	2002	CRP
25	Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction. (12393744)	May A.E.... Neumann F.J.	2002	ITGB2, PLAUR, VTN
26	Elevation of two molecular forms of adrenomedullin in plasma and urine in patients with acute myocardial infarction treated with early coronary angioplasty. (11115426)	Asakawa H.... Matsuoka H.	2001	ADM
27	The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. (11704395)	Zeymer U.... Neuhaus K.L.	2001	SLC9A1
28	Cost-effectiveness of intense insulin treatment after acute myocardial infarction in patients with diabetes mellitus; results from the DIGAMI study. (10739728)	Almbrand B.... RydAcn L.	2000	INS
29	Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)	Kimura T.... Kobayashi I.	2000	IL6
30	Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. (10933737)	SchAPmig A.... Schwaiger M.	2000	PLAT
31	Catecholamines induce IL-10 release in patients suffering from acute myocardial infarction by transactivating its promoter in monocytic but not in T-cells. (11108135)	Riese U.... Platzer C.	2000	IL10
32	Role of monocytes in the early phase of acute myocardial infarction. (11218621)	Aliberti G.... Minisola S.	2000	PIK3C2A, SLC17A5
33	Plasma vasoactive peptides after acute myocardial infarction in relation to left ventricular dysfunction. (10362366)	Uusimaa P.... Peuhkurinen K.	1999	EDN1, NPPB, NPPA
34	Effectiveness of early coronary angioplasty and abciximab for failed thrombolysis (reteplase or alteplase) during acute myocardial infarction (results from the GUSTO-III trial). Global Use of Strategies To Open occluded coronary arteries. (10513773)	Miller J.M.... Califf R.M.	1999	PLAT
35	Influence of prior ACE inhibitor therapy on morbidity and mortality following acute myocardial infarction. (9825077)	Raggi P.... Russell D.C.	1998	ACE
36	Pretreatment plasminogen activator inhibitor-1 (PAI-1) levels and the outcome of thrombolysis with streptokinase in patients with acute myocardial infarction. (9736130)	Sinkovic A.	1998	SERPINE1
37	Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study Group. (9169397)	Malmberg K.	1997	INS
38	Effects of angiotensin-converting enzyme inhibitor on plasma B-type natriuretic peptide levels in patients with acute myocardial infarction. (9547443)	Mizuno Y.... Nakao K.	1997	NPPB
39	Early versus delayed angiotensin-converting enzyme in hibition therapy in acute myocardial infarction. The healing and early afterloa d reducing therapy trial. (9193433)	Pfeffer M.A.... Hennekens C.H.	1997	ACE
40	Cardiac troponin, CK-MB and myoglobin for the early detection of acute myocardial infarction and monitoring of reperfusion following thrombolytic therapy. (7664479)	Apple F.S.... Henry T.D.	1995	TNNI3, TNNT2, MB
41	Relationship between early peaking of serum myosin light chain 1 level and washout phenomenon of creatine kinase in acute myocardial infarction (8164150)	Okumachi F.... Kato H.	1994	CHKB, MYL4
42	Atrial natriuretic peptide response is blunted in patients with acute myocardial infarction and mild left ventricular dysfunction. (8174145)	Derchi G.... Vecchio C.	1994	NPPA
43	Serial changes in plasma concentration of plasminogen activator inhibitor-1 before and serially after thrombolytic therapy for acute myocardial infarction. (8402755)	Goto S.... Ikeda Y.	1993	PLAT, SERPINE1
44	Coronary thrombolysis with K1K2Pu, a chimeric tissue- type and urokinase-type plasminogen activator: a feasibility study in six patie nts with acute myocardial infarction. (8269200)	Van de Werf F.... Collen D.	1993	PLAT
45	Angiotensin-converting enzyme inhibition during throm bolytic therapy in acute myocardial infarction: the Captopril and Thrombolysis Study (CATS). (8125421)	Kingma J.H.... van Gilst W.H.	1993	KNG1
46	Cardiac enzymes. How to use serial determinations to confirm acute myocardial infarction. (1437917)	Ruzich R.S.	1992	CHKB
47	Comparative effects of APSAC and rt-PA on infarct size and left ventricular function in acute myocardial infarction. A multicenter randomized study. (1909218)	Bassand J.P.... Schiele F.	1991	PLAT
48	Kinetic analyses of creatine kinase release patterns in patients with acute myocardial infarction undergoing emergency coronary arteriography. (2232111)	Horie M.... Kawai C.	1990	CHKB
49	Thrombolytic therapy in acute myocardial infarct (2198644)	Verstraete M.	1990	PLAT
50	Serial thrombolysis-related changes after thrombolytic therapy with TPA in patients with acute myocardial infarction. (1693793)	Ho C.H.... Wang S.P.	1990	SERPINF2

Genes related to acute myocardial infarction according to GeneCards:

(show top 50)    (show all 331)

id	Symbol	Description	Score	GeneCards Section Context
1	NPPA	natriuretic peptide A	11.0	Publications
2	PLAT	plasminogen activator, tissue	11.0	Publications
3	CHKB	choline kinase beta	11.0	Publications
4	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	11.0	Publications
5	MB	myoglobin	11.0	Publications
6	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
7	SAA4	serum amyloid A4, constitutive	11.0	Publications
8	NPPB	natriuretic peptide B	11.0	Publications
9	MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	11.0	Publications
10	TNNI3	troponin I type 3 (cardiac)	11.0	Publications
11	TNNT2	troponin T type 2 (cardiac)	11.0	Publications
12	PTX3	pentraxin 3, long	11.0	Publications
13	AHSP	alpha hemoglobin stabilizing protein	11.0	Publications
14	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
15	ADM	adrenomedullin	11.0	Publications
16	MYL4	myosin, light chain 4, alkali; atrial, embryonic	11.0	Publications
17	CTF1	cardiotrophin 1	11.0	Publications
18	CA3	carbonic anhydrase III, muscle specific	11.0	Publications
19	HYOU1	hypoxia up-regulated 1	11.0	Publications
20	CKB	creatine kinase, brain	11.0	Publications
21	CKM	creatine kinase, muscle	11.0	Publications
22	CRP	C-reactive protein, pentraxin-related	11.0	Publications
23	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0	Publications
24	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
25	FGA	fibrinogen alpha chain	11.0	Publications
26	PLK4	polo-like kinase 4	11.0	Publications
27	FABP12	fatty acid binding protein 12	11.0	Publications
28	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
29	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
30	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
31	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
32	SAA1	serum amyloid A1	11.0	Publications
33	OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	11.0	Publications
34	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
35	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
36	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	11.0	Publications
37	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.0	Publications
38	CDH5	cadherin 5, type 2 (vascular endothelium)	11.0	Publications
39	GPX3	glutathione peroxidase 3 (plasma)	11.0	Publications
40	CHKA	choline kinase alpha	11.0	Publications
41	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
42	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
43	UTS2	urotensin 2	11.0	Publications
44	ADRB1	adrenoceptor beta 1	11.0	Publications
45	MDH2	malate dehydrogenase 2, NAD (mitochondrial)	11.0	Publications
46	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
47	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
48	ADAM17	ADAM metallopeptidase domain 17	11.0	Publications
49	HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	11.0	Publications
50	PGF	placental growth factor	11.0	Publications

Pathways related to acute myocardial infarction according to GeneDecks:

(show top 50)    (show all 105)

id	Pathway	Score	Top Affiliating Genes
1	Complement and coagulation cascades20	12.3	VWF, SERPINC1, SERPINF2, SERPIND1, SERPINA1, SERPINE1
2	Blood Coagulation Signaling Pathways37	11.9	VWF, SERPINC1, SERPINF2, SERPIND1, SERPINE1, FGB
3	Extrinsic Prothrombin Activation Pathway36	11.5	SERPINC1, FGA, FGB, FGG, F7, F5
4	Transendothelial Migration of Leukocytes36	11.2	VCAM1, CDH5, ITGA2, ITGA2B, ITGA3, ITGAM
5	ACE Inhibitor Pathway, Pharmacodynamics34	11.0	BDKRB2, MME, NR3C2, AGTR1, AGTR2
6	Glioma Invasiveness36	10.9	KITLG, VTN, UTS2, ITGA2B, ITGA3, ITGAM
7	Actin-Based Motility by Rho Family GTPases36	10.5	UTS2, ITGA2B, ITGAM, IGF1, GNB3, PPBP
8	Paxillin Interactions36	10.2	KITLG, UTS2, KDR, ITGA2, ITGA2B, ITGA3
9	Akt Signaling36	10.1	PIK3CG, UTS2, ITGA2, ITGA2B, ITGAM, ITGB2
10	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.1	REN, BDKRB2, MME, MAPK1, CYP11B2, NR3C2
11	Ras Pathway36	10.1	UTS2, KDR, ITGA2, ITGA2B, ITGA3, ITGAM
12	PTEN Pathway36	10.0	KITLG, UTS2, KDR, ITGA2, ITGA2B, ITGA3
13	Cell adhesion_Integrin inside-out signaling41	10.0	PIK3CG, ITGA2, ITGB1, ITGB3, FN1, FGA
14	Angiogenesis3	10.0	REN, KDR, CDH5, ITGB1, ITGB3, MMP2
15	Cell adhesion ECM remodeling10	10.0	VTN, SERPINE1, ITGB1, MMP1, MMP10, MMP14
16	Cell adhesion_ECM remodeling41	10.0	VTN, SERPINE1, ITGB1, MMP1, MMP10, MMP14
17	Cell adhesion Integrin inside-out signaling10	10.0	PIK3CG, ITGA2, ITGA2B, ITGB1, ITGB2, ITGB3
18	ILK Signaling36	9.9	KITLG, UTS2, KDR, CDH5, ITGAM, ITGB1
19	UPA-UPAR Pathway36	9.7	VTN, SERPINE1, JAK2, ITGA2, ITGA2B, ITGA3
20	Endothelin-1 Signaling Pathway36	9.3	FLT1, IL10, IL18, IL1A, IL1B, IL4
21	ERK Signaling36	9.2	KITLG, UTS2, ITGA2B, ITGA3, ITGAM, ITGB1
22	Hematopoietic cell lineage20	9.1	KITLG, CD36, CD14, CD34, ITGA2, ITGA2B
23	all-trans-Retinoic Acid Signaling in Brain36	9.1	IL10, IL18, IL1A, IL1B, IL4, IL6
24	Activation of PKA through GPCR36	9.1	KITLG, GCG, VASP, UTS2, KDR, FLT1
25	Pertussis20	9.0	SERPING1, CD14, ITGAM, ITGB1, ITGB2, IL10
26	Malaria20	8.6	SELE, SELP, VCAM1, CD36, CD40LG, CD40
27	PPAR Pathway36	8.6	KITLG, UTS2, ITGA2, ITGA2B, ITGA3, ITGAM
28	Rac1 Pathway36	8.5	KITLG, UTS2, KDR, ITGA2, ITGA2B, ITGA3
29	STAT3 Pathway36	8.5	JAK2, IL10, IL18, IL1A, IL1B, IL1R1
30	MIF Mediated Glucocorticoid Regulation36	8.5	CD14, IL10, IL18, IL1A, IL1B, IL4
31	MIF Regulation of Innate Immune Cells36	8.5	CD14, IL10, IL18, IL1A, IL1B, IL4
32	PEDF Induced Signaling36	8.4	IL10, IL18, IL1A, IL1B, IL4, IL6
33	Renin-Angiotensin Pathway36	8.4	REN, KITLG, VCAM1, UTS2, KDR, JAK2
34	NF-KappaB (p50-p65) Pathway36	8.4	KITLG, UTS2, KDR, FLT1, FGF2, IL1A
35	NF-KappaB Family Pathway36	8.4	KITLG, UTS2, KDR, FLT1, FGF2, IL1A
36	Rheumatoid arthritis20	8.4	VEGFA, ITGB2, MMP1, MMP3, FLT1, IL18
37	Pancreatic Adenocarcinoma36	8.3	KITLG, UTS2, KDR, JAK2, MMP1, MMP10
38	Rho Family GTPases36	8.3	KITLG, UTS2, KDR, CDH5, ITGA2, ITGA2B
39	Chagas disease (American trypanosomiasis)20	8.2	PIK3CG, SERPINE1, BDKRB2, IL10, IL1B, IL6
40	Pathways in cancer20	8.2	PIK3CG, VEGFA, JUP, ITGA2, ITGA2B, ITGB1
41	PAK Pathway36	7.9	KITLG, UTS2, KDR, FLT1, FGF2, IL10
42	Tec Kinases Signaling36	7.9	KITLG, UTS2, JAK2, ITGA2, ITGA2B, ITGA3
43	TGF-Beta Pathway36	7.7	KITLG, UTS2, KDR, FLT1, FGF2, IL10
44	Cytokine-cytokine receptor interaction20	7.6	CNTF, KITLG, VEGFA, KDR, LEP, CD40LG
45	Antioxidant Action of Vitamin-C36	7.4	KITLG, UTS2, KDR, JAK2, FLT1, FGF2
46	JAK-STAT Pathway36	7.2	KITLG, UTS2, KDR, JAK2, FLT1, FGF2
47	MAPK Family Pathway36	7.0	KITLG, UTS2, KDR, FLT1, FGF2, IL10
48	Molecular Mechanisms of Cancer36	INF	PIK3CG, , KITLG, UTS2, KDR, ITGA2
49	p38 Signaling36	INF	KITLG, UTS2, KDR, FLT1, FGF2,
50	MAPK Signaling36	INF	KITLG, UTS2, KDR, ITGA2, ITGA2B, ITGA3

Compounds related to acute myocardial infarction according to GeneDecks:

(show top 50)    (show all 589)

id	Compound	Score	Top Affiliating Genes
1	sodium32 18	13.6	PIK3C2A, REN, RETN, NAGLU, UTS2, BLZF1
2	endotoxin32	12.3	RETN, SELL, SERPINF2, CHKB, SAA1, SAA4
3	phospholipid32	12.1	COG2, VWF, SERPINA1, LPL, LIPG, LIPC
4	warfarin32 34 9 18 9	15.8	PIK3C2A, VWF, SELP, SERPINC1, LPA, MTHFR
5	sialic acid32	11.7	SELL, SELPLG, SERPINF2, SERPINA3, NAGLU, LPA
6	aspartate32	11.6	PIK3C2A, RETN, VTN, SELP, VIP, NAGLU
7	clopidogrel32 34 9 18 9	15.5	SERPINC1, VASP, P2RY12, CD40LG, CD63, CD40
8	nadph32 18	12.4	UTS2, BDKRB2, MDH2, GLUD1, CYP2C19, CYP2D6
9	progesterone32 42 9 18 9	15.4	CNTF, SETD2, SERPINA3, BSG, PAPPA, CKB
10	p00232	11.4	RETN, LPA, LIPC, PAPPA, LEP, MTHFR
11	adenine32 9 18 9	14.4	VWF, SETD2, KCNJ11, LEP, MTHFR, XDH
12	enalaprilat32	11.3	REN, VCAM1, BDKRB2, XDH, MME, PLAT
13	ionomycin32	11.2	SETD2, SERPINA3, CD40, CCL3, ADAM17
14	carvedilol32 34 9 9	14.2	REN, SELE, VEGFA, VCAM1, XDH, CYP2D6
15	amlodipine32 9 18 9	14.1	REN, SERPINE1, VCAM1, ALB, HMGCR, CYP2C8
16	aprotinin32 9 9	13.1	VWF, SELP, SERPINC1, SERPINF2, VIP, NAGLU
17	methionine32	11.0	CNTF, VWF, SERPINA1, SERPINA3, LPA, LIPC
18	aspirin32 34 18	13.0	COG2, KITLG, VWF, VTN, SELE, SELL
19	silicone32	10.9	CNTF, VTN, SELE, SERPINC1, CD36, CD40LG
20	cholesterol ester32	10.9	COG2, LPA, LIPC, LCAT, CETP, APOA1
21	palmitate32	10.8	GCG, SELE, CETP, APOA1, FABP3, FABP12
22	bezafibrate32 9 9	12.8	PIK3C2A, COG2, SERPINE1, LPA, LPL, LIPC
23	estrogen32	10.8	COG2, RETN, VWF, GCG, SERPINC1, SETD2
24	progestin32	10.7	SERPINC1, VEGFA, PAPPA, KDR, APOA1, IGFBP1
25	lidocaine32 9 9	12.5	SERPINC1, SCN5A, CHKB, ITGAM, ITGB2, FGF2
26	rituximab32 34 9 9	13.5	CD40LG, CD40, IL10, IL1R1, IL2RA, MCL1
27	gsno32	10.4	SELP, SETD2, XDH, FN1, GSR, GSTP1
28	fenofibrate32 9 9	12.3	PIK3C2A, COG2, RETN, SELE, SELP, SERPINE1
29	raloxifene32 9 9	12.3	VWF, SERPINC1, SERPINE1, CKB, CHKB, CD36
30	peptidoglycan32	10.3	CD14, IL10, IL1B, IL1R1, IL1RN, IL8
31	fluorescein32 9 9	12.1	SERPINC1, VEGFA, MPO, CD40LG, ITGAM, MMP2
32	leflunomide32 9 9	12.1	SAA4, MMP1, MMP3, IL1R1, IL1RN, IL6
33	glycerol32 9 18 9	13.0	PIK3C2A, VWF, GCG, SERPINC1, LPL, LIPC
34	valine32	9.6	SERPINA3, VIP, LPL, KCNJ11, SCN5A, MTHFR
35	quercetin32 42 9 18 9	13.5	PIK3C2A, PIK3CG, SELE, VCAM1, XDH, MME
36	dihydrotestosterone32 9 18 9	12.5	SETD2, SERPINE1, VIP, LPL, LEP, CHKA
37	wortmannin32 42	10.5	PIK3C2A, PIK3CG, CNTF, KITLG, VTN, GCG
38	doxycycline32 9 9	11.4	CD40LG, MMP1, MMP2, MMP3, MMP9, GSTP1
39	tamoxifen32 34 9 9	12.2	VTN, SELE, SERPINC1, VEGFA, LPL, VCAM1
40	ang ii32	9.0	PIK3CG, REN, VEGFA, JAK2, CD36, MAPK1
41	gf 109203x32 42	10.0	PIK3CG, KITLG, VEGFA, JAK2, ITGA2B, MMP1
42	arsenite32 18	9.9	PIK3CG, SETD2, VEGFA, JAK2, MMP1, MMP9
43	rantes32	8.6	KITLG, SELE, SELL, SELP, VIP, VCAM1
44	poly(i-c)32	8.6	VCAM1, IL18, IL1B, IL4, IL6, IL8
45	neopterin32	8.3	NAGLU, CHKB, LCN2, SAA4, CD14, CD40LG
46	cytochalasin d32 42	9.1	PIK3CG, KITLG, VWF, VTN, SELE, SELL
47	pd 98,05932	7.4	PIK3CG, CNTF, KITLG, VTN, GCG, SETD2
48	rosiglitazone32 9 18 9	10.3	PIK3CG, COG2, RETN, SELE, SERPINE1, LPA
49	steroid32	INF	PIK3C2A, REN, RETN, KITLG, SERPINA3, NAGLU
50	proline32	INF	SETD2, BSG, LPA, VASP, BDKRB2, AVP

Cellular components related to acute myocardial infarction according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	12.0	F8, TNFRSF11B, TNFSF10, TNFSF11, TEK, PTX3
2	integral to plasma membrane	GO:005887	10.9	SELL, SELP, SELPLG, CLEC4A, BDKRB2, KDR
3	proteinaceous extracellular matrix	GO:005578	10.7	TNC, TNFRSF11B, SPARC, TGFB1, POSTN, ADAMTS1
4	high-density lipoprotein particle	GO:034364	10.6	PON1, APOH, APOE, APOA5, APOA2, APOA1
5	platelet alpha granule lumen	GO:031093	9.8	FGB, FGG, IGF1, F8, F5, ALB
6	extracellular space	GO:005615	9.6	ADAMTS13, ADM, ADAMTS4, ADIPOQ, HGF, EPO
7	membrane raft	GO:045121	9.6	TEK, EDNRA, TLR4, CXADR, SLC9A1, SLC6A4
8	external side of plasma membrane	GO:009897	8.9	KCNJ5, CD36, CD40LG, CD34, CD40, ITGA2
9	plasma membrane	GO:005886	INF	F7, TNF, TEK, OLR1, CTLA4, CTNNB1
10	cell surface	GO:009986	INF	TPO, TNF, TEK, PLAT, PLAU, PLAUR

Biological processes related to acute myocardial infarction according to GeneDecks:

(show top 50)    (show all 62)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte migration	GO:050900	11.7	SELL, SELP, SELPLG, BSG, CD34, ITGA3
2	proteolysis	GO:006508	11.5	REN, LPA, PAPPA, MME, MMP1, MMP10
3	response to lipopolysaccharide	GO:032496	11.5	SELE, SELP, SERPINA1, KCNJ8, JAK2, MMP9
4	fibrinolysis	GO:042730	11.3	SERPINF2, SERPINE1, SERPING1, GP1BA, F2, F12
5	acute-phase response	GO:006953	11.3	SERPINF2, SERPINA1, SERPINA3, SAA1, SAA4, FN1
6	cell adhesion	GO:007155	11.3	KITLG, VWF, VTN, SELL, SELP, SELPLG
7	blood coagulation, intrinsic pathway	GO:007597	11.3	VWF, SERPING1, APOH, GP5, GP1BA, F8
8	small molecule metabolic process	GO:044281	11.2	PIK3C2A, PIK3CG, GCG, BSG, NAGLU, LPA
9	positive regulation of vasodilation	GO:045909	10.9	UTS2, INS, CALCA, HMOX1, NOS1, NOS3
10	cell-cell signaling	GO:007267	10.9	AVP, ITGB2, INHBA, INS, IL10, IL18
11	lipoprotein metabolic process	GO:042157	10.7	LPA, LPL, LCAT, CETP, APOA1, APOA2
12	blood coagulation	GO:007596	10.7	PIK3CG, KIF2C, VWF, SELL, SELP, SELPLG
13	elevation of cytosolic calcium ion concentration	GO:007204	10.7	UTS2, BDKRB2, SAA1, AVP, JAK2, IL1B
14	positive regulation of blood coagulation	GO:030194	10.7	SERPINE1, CD36, APOH, F7, F2, F2R
15	leukocyte cell-cell adhesion	GO:007159	10.7	SELE, SELP, VCAM1, CD40LG, ITGB1, ITGB2
16	extracellular matrix disassembly	GO:022617	10.7	MMP1, MMP10, MMP14, MMP2, MMP3, MMP9
17	organ regeneration	GO:031100	10.6	APOA2, APOA5, APOH, ANGPT2, ANGPT1, CCL2
18	positive regulation of interleukin-8 production	GO:032757	10.5	SERPINE1, IL18, IL1B, CALCA, TLR2, TLR3
19	regulation of blood pressure	GO:008217	10.5	REN, UTS2, LEP, CD34, GNB3, CALCA
20	cell surface receptor signaling pathway	GO:007166	10.4	BSG, CLEC4A, BDKRB2, CD36, CD14, INHBA
21	aging	GO:007568	10.3	VCAM1, IL1B, FAS, CCL2, CCL5, F3
22	response to glucocorticoid stimulus	GO:051384	10.3	SERPINE1, LCAT, IL10, IL1B, IL1RN, IL6
23	platelet degranulation	GO:002576	10.3	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, SERPING1
24	response to ethanol	GO:045471	10.3	AVP, MMP9, IL4, CCL2, ICAM1, GOT2
25	female pregnancy	GO:007565	10.2	PAPPA, LEP, FLT1, IL1RN, IL4, GPX3
26	positive regulation of angiogenesis	GO:045766	10.2	SERPINE1, VEGFA, UTS2, KDR, CHI3L1, CD34
27	neutrophil chemotaxis	GO:030593	10.1	PIK3CG, CKLF, SAA1, ITGB2, IL1B, IL8
28	positive regulation of tumor necrosis factor production	GO:032760	10.0	JAK2, CD36, CD14, IL18, CCL3, IFNG
29	inflammatory response	GO:006954	10.0	PIK3CG, SELE, SELP, SERPINA3, BDKRB2, CHI3L1
30	response to hypoxia	GO:001666	10.0	SERPINA1, VEGFA, VCAM1, UTS2, LEP, MMP9
31	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.8	CNTF, SELP, KDR, JAK2, FLT1, INS
32	positive regulation of cell migration	GO:030335	9.8	VEGFA, KDR, JAK2, ITGB1, MMP14, FLT1
33	cellular response to mechanical stimulus	GO:071260	9.8	CD40, ITGB1, IL18, IL1B, FAS, CASP1
34	platelet activation	GO:030168	9.7	PIK3CG, VWF, SELP, SERPINF2, SERPINA1, SERPINE1
35	signal transduction	GO:007165	9.4	CNTF, KITLG, GCG, CHKA, AVP, JAK2
36	positive regulation of MAP kinase activity	GO:043406	9.4	PIK3CG, KITLG, VEGFA, CD40, FLT1, HTR2A
37	response to drug	GO:042493	9.3	REN, LPL, UTS2, BDKRB2, KCNJ11, ITGB1
38	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.3	GCG, SERPINF2, KDR, CHI3L1, FGF2, IL1A
39	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	JAK2, INS, IL1B, IFNG, ICAM1, TNF
40	positive regulation of protein kinase B signaling cascade	GO:051897	9.3	PIK3CG, CHI3L1, INS, ANGPT1, CCL3, GPX1
41	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.2	KITLG, VTN, VEGFA, JAK2, CD36, ITGB1
42	lipopolysaccharide-mediated signaling pathway	GO:031663	9.2	IL18, IL1B, CCL2, CCL3, CCL5, TNF
43	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.1	CD40, INS, IL1B, IL6, ICAM1, CAT
44	positive regulation of MAPK cascade	GO:043410	9.0	CNTF, KDR, LEP, CD36, ITGB1, FLT1
45	positive regulation of cell proliferation	GO:008284	8.7	CNTF, VIP, VEGFA, KDR, LEP, AVP
46	negative regulation of apoptotic process	GO:043066	8.6	PIK3CG, GCG, SERPINE1, VEGFA, BDKRB2, KDR
47	anti-apoptosis	GO:006916	8.5	MPO, CD40LG, GSTP1, IL10, IL1A, IL1B
48	negative regulation of cell proliferation	GO:008285	8.4	BDKRB2, JAK2, CDH5, ITGB1, INHBA, FGF2
49	heart development	GO:007507	INF	VCAM1, KCNJ8, , MB, CASP3, TNNI3
50	positive regulation of apoptotic process	GO:043065	INF	, JAK2, ITGB1, MMP9, IL1B, FAS

Molecular functions related to acute myocardial infarction according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	ADAMTS4, ADAM17, ADM, ADRB2, ADAMTS13, PECAM1
2	heparin binding	GO:008201	11.0	VEGFA, SERPIND1, SERPINC1, SELP, SELL, VTN
3	protease binding	GO:002020	10.5	IL1R1, F3, TNF, ELANE, CST3, ADAMTS4
4	eukaryotic cell surface binding	GO:043499	10.3	ADIPOQ, TGFB1, ANXA5, MBL2, APOH, FGG
5	heme binding	GO:020037	10.2	CYP2C8, CYP2D6, CYCS, CYP27B1, CYP3A5, CYP2C9
6	hormone activity	GO:005179	10.2	EPO, LEP, UTS2, VIP, GCG, RETN
7	cytokine activity	GO:005125	8.4	GDF15, ADIPOQ, CSF3, THPO, EDN1, LTA
8	growth factor activity	GO:008083	8.1	PPBP, AGT, THPO, TGFB1, CXCL12, NUDT6
9	protein homodimerization activity	GO:042803	INF	TGFB1, ACVR1, ABCG2, SHBG, NFKB1, CRP
10	receptor binding	GO:005102	INF	TNFSF10, TNC, CALCA, CAT, HSPA8, F2R