MCID: ACT075
MIFTS: 61

Acute Myocardial Infarction malady

Cardiovascular diseases category

Summaries for Acute Myocardial Infarction

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Acute Myocardial Infarction is related to myocardial infarction and coronary artery disease. An important gene associated with Acute Myocardial Infarction is NPPA (natriuretic peptide A), and among its related pathways are Selenium Pathway and Complement and coagulation cascades. The compounds creatinine and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Acute Myocardial Infarction

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

acute myocardial infarction 8 44 60


External Ids:

Disease Ontology8 DOID:9408
ICD9CM27 410, 410.9, 410.90
NCIt39 C35204
ICD1025 I21

Related Diseases for Acute Myocardial Infarction

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Myocardial Infarction family:

Posterior Myocardial Infarction acute myocardial infarction
Myocardial Infarction, Susceptibility to, 1 Myocardial Infarction 2

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 317)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction32.7SAA4, MB, TNNT2, TNNI3, NPPB, NPPA
2coronary artery disease31.1SELP, ACE, THBD, PLAT, AHSP, CHKB
3coronary stenosis31.1SELP
4myocarditis31.0MB, TNNT2, TNNI3, NPPB, CHKB
5diabetes mellitus31.0NPPB, NPPA, PIK3C2A, CRP, PLAT, THBD
6hypertension31.0NPPB, NPPA, CRP, PLAT, ACE, ADM
7ischemia30.8CHKB, SELP, ADM, MB, PLAT, AHSP
8atherosclerosis30.8CRP, AHSP, PLAT, THBD, ACE, PTX3
9stroke, ischemic30.8SELP, THBD, PLAT
10congestive heart failure30.8NPPB, NPPA, FABP3, CTF1, ACE, ADM
11obesity30.8SAA4, FABP12, FABP3, CRP
12hyperhomocysteinemia30.7CRP, PLAT, SELP, THBD
13coronary artery vasospasm30.7AHSP, CHKB
14hyperglycemia30.7ACE, CRP, AHSP
15lupus erythematosus30.7THBD
16ventricular septal defect30.7TNNI3
17thrombophilia30.6PLAT, THBD, SELP, SERPINF2
18thrombocytosis30.6SERPINF2, SELP, THBD, CRP
19kawasaki disease30.6ADM, CRP, NPPB
20thrombocytopenia30.6PIK3C2A, SELP, THBD
21antiphospholipid syndrome30.6SELP, PLAT, THBD
22systemic lupus erythematosus30.6CRP
23pneumonia30.5CRP, ADM, PIK3C2A, MB, SAA4
24cerebrovascular disease30.5SELP, ACE, ADM
25leukemia30.5CTF1, FABP12, SERPINF2
26hyperuricemia30.5PIK3C2A
27ischemic heart disease30.4TNNI3, TNNT2, MB, NPPB, ADM, SELP
28type 2 diabetes mellitus30.4SELP, CRP, PLAT, SERPINF2, ACE, THBD
29intermediate coronary syndrome30.4PIK3C2A, TNNI3, TNNT2, MB, PLAT
30disseminated intravascular coagulation30.4MB, PLAT, PIK3C2A, THBD, SERPINF2
31vasculitis30.4PTX3, THBD, CRP, SELP
32dementia30.4PIK3C2A, FABP3
33arteriosclerosis30.4ADM, AHSP
34periodontal disease30.4CRP, SERPINF2
35neuropathy30.4PIK3C2A, MB
36pheochromocytoma30.4NPPA, ADM
37sleep disorder30.4CHKB
38atrioventricular block30.4NPPB, PIK3C2A
39rheumatoid arthritis30.1SAA4, CHKB, MB, CRP, SELP, PTX3
40vascular disease30.1CRP, AHSP, SELP, ACE, THBD, PLAT
41proteinuria30.1CRP, ADM, SAA4, PIK3C2A, ACE
42pulmonary embolism30.1NPPB, FABP3, PLAT, SERPINF2
43arthritis30.1CRP, MB, SAA4
44neuroleptic malignant syndrome30.1MB, PIK3C2A, CHKB
45hypertrophic cardiomyopathy30.1TNNI3, TNNT2
46respiratory failure30.1PIK3C2A, CRP
47cardiac rupture30.1CHKB, PLAT
48acute pancreatitis30.1CRP, MB
49polycythemia vera30.1THBD, SELP
50eosinophilia30.1PIK3C2A, MB

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to acute myocardial infarction

Clinical Features for Acute Myocardial Infarction

About this section

Drugs & Therapeutics for Acute Myocardial Infarction

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Myocardial Infarction

Drug clinical trials:

Search ClinicalTrials for Acute Myocardial Infarction

Search NIH Clinical Center for Acute Myocardial Infarction

Search CenterWatch for Acute Myocardial Infarction

Genetic Tests for Acute Myocardial Infarction

About this section

Anatomical Context for Acute Myocardial Infarction

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Acute Myocardial Infarction:

32
Heart, Endothelial, Brain, Monocytes, Testes, Bone, Bone marrow, Kidney, Prostate, Thyroid, Lung, Liver, Whole blood, Skeletal muscle, Atrioventricular node, Spinal cord, Myeloid, T cells, Spleen, Small intestine, Pituitary

Animal Models for Acute Myocardial Infarction or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Acute Myocardial Infarction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2PIK3C2A, CTF1, FABP3, NPPA, TNNT2, MB
2MP:000538512.0ADM, MB, TNNT2, TNNI3, NPPB, NPPA
3MP:001076811.7MB, TNNT2, TNNI3, FABP3, PIK3C2A, AHSP
4MP:000536911.6MB, TNNT2, TNNI3, NPPB, NPPA, FABP3
5MP:000538711.4PIK3C2A, CRP, AHSP, PLAT, THBD, ACE
6MP:000539711.4NPPA, PIK3C2A, AHSP, PLAT, THBD, ACE
7MP:000538811.0MB, TNNI3, THBD, PTX3
8MP:000536710.8NPPA, PIK3C2A, THBD, ACE, SELP, ADM

Publications for Acute Myocardial Infarction

About this section
Sources:
50PubMed
See all sources

Articles related to Acute Myocardial Infarction:

(show top 50)    (show all 2975)
idTitleAuthorsYear
1
Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction. (24339298)
2014
2
Impact of a Chronic Total Occlusion in a Non-Infarct Related Artery on Clinical Outcomes Following Primary Percutaneous Intervention in Acute ST-Elevation Myocardial Infarction. (24402805)
2014
3
Inotropic agents and vasodilator strategies for acute myocardial infarction complicated by cardiogenic shock or low cardiac output syndrome. (24385385)
2014
4
Comparison of triple anti-platelet therapy and dual anti-platelet therapy in patients with acute myocardial infarction who had no-reflow phenomenon during percutaneous coronary intervention. (23986083)
2013
5
The impact of cardiac and noncardiac comorbidities on the short-term outcomes of patients hospitalized with acute myocardial infarction: a population-based perspective. (24235847)
2013
6
Bypassing the emergency department and time to reperfusion in patients with prehospital ST-segment-elevation: findings from the reperfusion in acute myocardial infarction in Carolina Emergency Departments project. (23861465)
2013
7
Current cigarette smoking is an independent risk factor for subacute stent thrombosis in acute myocardial infarction patients. (24239276)
2013
8
Atrial fibrillation in Middle Eastern Arab and South Asian patients hospitalized with acute myocardial infarction: experience from a 20-year registry in qatar (1991-2010). (23705560)
2013
9
Could glucose management after acute myocardial infarction cure myocardial damage? (24304536)
2013
10
Adenosine and verapamil for no-reflow during primary percutaneous coronary intervention in people with acute myocardial infarction. (23736949)
2013
11
Edema is a sign of early acute myocardial infarction on post-mortem magnetic resonance imaging. (23783421)
2013
12
Intensive glucose control in diabetics with an acute myocardial infarction does not improve mortality and increases risk of hypoglycemia-a meta-regression analysis. (22724474)
2013
13
Creatinine-or cystatin C-based equations to estimate glomerular filtration rate in acute myocardial infarction: a disparity in estimating renal function and in mortality risk prediction. (23714598)
2013
14
Differentiation of acute myocarditis and acute myocardial infarction by the regional distribution of myocardial irreversible injury using cardiovascular magnetic resonance imaging. (22588344)
2012
15
Acute myocardial infarction and cardiogenic shock: prognostic impact of cytokines: INF-I^, TNF-I+, MIP-1I^, G-CSF, and MCP-1I^. (22810435)
2012
16
Glutathione S-transferase gene polymorphism as a susceptibility factor for acute myocardial infarction and smoking in the North Indian population. (21389716)
2011
17
Plasma B-type natriuretic peptide level can predict myocardial tissue perfusion in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. (21701385)
2011
18
Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome. (19770739)
2010
19
Level and prognostic value of serum myeloperoxidase in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. (19246814)
2009
20
Impaired glucose tolerance and endothelial damage, as assessed by levels of von Willebrand factor and circulating endothelial cells, following acute myocardial infarction. (20021313)
2009
21
The utility of the standard 12-lead electrocardiogram in the prediction of proximal right coronary artery occlusion in acute inferior myocardial infarction. (18296012)
2008
22
The relationship between leptin and obesity and cardiovascular risk factors in men with acute myocardial infarction. (18651469)
2007
23
Measuring soluble CD40 ligand:interleukin-10 ratio as a prognostic marker in acute myocardial infarction: yet another prognostic biomarker? (17610938)
2007
24
Effects of receipt of chronic statin therapy before the onset of acute myocardial infarction: a retrospective study in patients undergoing primary percutaneous coronary intervention. (17213001)
2006
25
Prognostic implications of PR-segment depression in inferior leads in acute inferior myocardial infarction. (16933578)
2006
26
Association between right bundle branch block and impaired myocardial tissue-level reperfusion in patients with acute myocardial infarction. (16697336)
2006
27
Plasma 8-iso-prostaglandin F2alpha, a marker of oxidative stress, is increased in patients with acute myocardial infarction. (16517503)
2006
28
Plasma level of B-type natriuretic peptide as a prognostic marker after acute myocardial infarction: a long-term follow-up analysis. (15353502)
2004
29
Study on the reperfusion rate of acute myocardial infarction affected by inspiring nitric oxide and resolving thrombus intravenously before admission]. (15009968)
2004
30
Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction (results from Assessment of the Safety and Efficacy of a New Thrombolytic Regimens 2 and 3). (15276088)
2004
31
Serum B-type natriuretic peptide levels on admission predict not only short-term death but also angiographic success of procedure in patients with acute ST-elevation myocardial infarction treated with primary angioplasty. (15459597)
2004
32
Combined Abciximab REteplase Stent Study in acute myocardial infarction (CARESS in AMI). (15389222)
2004
33
Hepatocyte growth factor production may be related to the inflammatory response in patients with acute myocardial infarction. (11922273)
2002
34
Improving quality of care for acute myocardial infarction: The Guidelines Applied in Practice (GAP) Initiative. (11886318)
2002
35
ECG discrimination between right and left circumflex coronary arterial occlusion in patients with acute inferior myocardial infarction: value of old criteria and use of lead aVR. (12114348)
2002
36
Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction. (12390955)
2002
37
The use of intra-aortic balloon counterpulsation in patients with cardiogenic shock complicating acute myocardial infarction: data from the National Registry of Myocardial Infarction 2. (11376306)
2001
38
Negative T waves shortly after ST-elevation acute myocardial infarction are a powerful marker for improved survival rate. (10966535)
2000
39
Comparison between strategies using creatine kinase-MB(mass), myoglobin, and troponin T in the early detection or exclusion of acute myocardial infarction in patients with chest pain and a nondiagnostic electrocardiogram. (11113415)
2000
40
Echocardiographic findings, pro-ANP and treatment in acute myocardial infarction without overt heart failure]. (10494198)
1999
41
Reperfusion therapy for acute myocardial infarction. Which strategy for which patient? (9664197)
1998
42
Elevated plasma levels of soluble P-selectin in patients with acute myocardial infarction and unstable angina. An inverse link to lipoprotein(a). (9672405)
1998
43
Levels of CK MB mass in patients with acute myocardial infarct treatedwith fibrinolysis. Comparison with levels of CK, CKMB, CKMB mass and troponin T in the diagnosis of coronary ischemia]. (9650501)
1997
44
Comparison of saruplase and alteplase in acute myocardial infarction. SESAM Study Group. The Study in Europe with Saruplase and Alteplase in Myocardial Infarction. (9070549)
1997
45
Early 'rule-in' diagnosis of acute myocardial infarction 4 h post admission for rapid risk stratification by creatine kinase increment (creatine kinase change). (8836388)
1996
46
Ridogrel as an adjunct to thrombolysis in acute myocardial infarction. (8749872)
1995
47
Role of MB isoforms (isomers) in the early diagnosis of acute myocardial infarction. (8069015)
1994
48
Creatine kinase MB isoforms for early diagnosis and monitoring of acute myocardial infarction. (1606705)
1992
49
Clinical trial of 111In-antimyosin antibody imaging: (4). Effect of reperfusion in acute myocardial infarction]. (2348582)
1990
50
Acute myocardial infarction with normal coronary arteries. In vivo demonstration of coronary thrombosis during the acute episode. (6641040)
1983

Genetic Variations for Acute Myocardial Infarction

About this section

Expression for genes affiliated with Acute Myocardial Infarction

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Myocardial Infarction

Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for genes affiliated with Acute Myocardial Infarction

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems
See all sources

Pathways related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8PLAT, CRP, SAA4
2
Hide members
10.8PLAT, THBD, SERPINF2
3
Hide members
10.8SERPINF2, THBD, PLAT
4
Hide members
10.8SERPINF2, SELP, THBD
510.7SERPINF2, PLAT

Compounds for genes affiliated with Acute Myocardial Infarction

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1creatinine4412.8PIK3C2A, FABP3, FABP12, NPPA, NPPB, TNNI3
2cholesterol44 28 11 2415.4THBD, AHSP, CHKB, CRP, SAA4, FABP12
3lactate4412.2PIK3C2A, CRP, CHKB, THBD, SELP, ADM
4glucose4412.2CRP, ADM, ACE, THBD, PLAT, AHSP
5prostacyclin4412.0SELP, AHSP, CRP, ACE, THBD, PLAT
6ptca4412.0SERPINF2, ADM, SELP, SAA4, TNNT2, NPPB
7nitroglycerin44 1113.0NPPB, NPPA, PIK3C2A, CRP, PLAT, AHSP
8lipid4412.0SAA4, NPPB, FABP12, AHSP, FABP3, CRP
9vegf4411.9CHKB, THBD, SERPINF2, ADM, CRP, PIK3C2A
10arginine4411.9SERPINF2, SELP, THBD, NPPB, MB, NPPA
11homocysteine44 2412.9SELP, ADM, THBD, PLAT, AHSP, SAA4
12fibrinogen4411.9CRP, SAA4, PIK3C2A, CHKB, AHSP, PLAT
13losartan44 49 28 1114.8NPPB, ACE, CRP, PLAT, THBD, NPPA
14sodium nitroprusside4411.8PIK3C2A, NPPA, NPPB, MB, AHSP, PLAT
15aspirin44 49 28 2414.8PLAT, SELP, ACE, THBD, AHSP, CHKB
16epinephrine44 11 2413.8CHKB, NPPA, PIK3C2A, MB, SELP, SERPINF2
17fluvastatin44 49 28 1114.7SELP, THBD, PLAT, CHKB, CRP, PIK3C2A
18atorvastatin44 49 28 11 2415.7PIK3C2A, CHKB, CRP, SELP, THBD, PLAT
19citrate4411.6PIK3C2A, FABP3, MB, THBD, CHKB, SELP
20thyroxine44 2412.6NPPB, PIK3C2A, SERPINF2, THBD, PLAT, MB
21cyclosporin a44 28 5913.6NPPA, PLAT, NPPB, CHKB, SELP, ADM
22perindopril44 49 1113.6ACE, THBD, PLAT, CRP, NPPA, NPPB
23heparin44 28 11 2414.6MB, TNNT2, PIK3C2A, AHSP, SELP, CHKB
24fatty acid4411.5ADM, TNNT2, FABP3, PIK3C2A, FABP12, CHKB
25thromboxane44 2412.5PIK3C2A, THBD, AHSP, SELP, SERPINF2, PLAT
26kininogen4411.5SERPINF2, SELP, ACE, THBD, PLAT, NPPA
27prostaglandin f2alpha4411.5ADM, AHSP, SAA4, CRP, FABP12, MB
28pravastatin44 49 28 11 2415.5PIK3C2A, SELP, THBD, NPPB, CHKB, CRP
29norepinephrine44 11 2413.5CHKB, AHSP, ADM, FABP3, MB
30aprotinin44 1112.5THBD, PLAT, SELP, NPPB, MB, SERPINF2
31quinapril44 1112.4SELP, NPPA, PLAT, CRP, ACE
32endotoxin4411.4ADM, SAA4, CHKB, AHSP, THBD
33clopidogrel49 44 11 2414.4ACE, SELP, PLAT, CRP, CHKB
34desmopressin44 59 28 1114.3NPPA, SERPINF2, PLAT, THBD, SELP
35spec-t4411.3NPPA, PLAT, CHKB, ADM, NPPB
36mibg4411.3NPPB, FABP3, NPPA, ADM
37thallium4411.3CHKB, NPPB, PIK3C2A, FABP3
38prednisolone44 28 1113.3MB, CHKB, NPPB, PIK3C2A, CRP, THBD
39hirudin4411.3SERPINF2, SELP, THBD, PLAT, PIK3C2A
40uric acid44 2412.2SAA4, NPPB, PIK3C2A, CHKB
41omapatrilat4411.2PLAT, ACE, ADM, NPPA
42dobutamine44 28 1113.2NPPB, PLAT, CHKB, NPPA
43nitric oxide44 11 2413.2ADM, PTX3, SELP, AHSP, CHKB, NPPB
44fosinopril44 1112.1NPPA, NPPB, CRP, ACE
45simvastatin44 49 59 28 11 2416.1PIK3C2A, CHKB, PLAT, THBD, SELP, CRP
46enalaprilat4411.0NPPB, ACE, PLAT, NPPA
47tirofiban44 1111.9CRP, SELP, PLAT, NPPB
48mannitol44 1111.9CRP, MB
49captopril44 28 49 59 1114.8AHSP, ADM
50warfarin44 49 11 2413.6SELP, PIK3C2A

GO Terms for genes affiliated with Acute Myocardial Infarction

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.4ADM, NPPB, NPPA, CTF1, CRP, PLAT
2extracellular regionGO:00557611.3SAA4, NPPB, NPPA, CTF1, CRP, PLAT
3troponin complexGO:00586110.7TNNI3, TNNT2

Biological processes related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:00166611.2ADM, PLAT, CRP, MB
2acute-phase responseGO:00695311.1SERPINF2, CRP, SAA4
3response to insulin stimulusGO:03286811.0NPPA, FABP3, ADM
4regulation of blood pressureGO:00821711.0ACE, NPPA, NPPB
5negative regulation of ATPase activityGO:03278010.9TNNT2, TNNI3
6female pregnancyGO:00756510.9ADM, THBD, NPPA
7opsonizationGO:00822810.8CRP, PTX3
8cGMP biosynthetic processGO:00618210.8NPPA, NPPB
9regulation of blood vessel sizeGO:05088010.7NPPA, NPPB
10negative regulation of fibrinolysisGO:05191810.7THBD, SERPINF2
11receptor guanylyl cyclase signaling pathwayGO:00716810.6NPPA, NPPB
12regulation of vasodilationGO:04231210.4ACE, NPPB

Molecular functions related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8ADM, NPPA, NPPB
2troponin C bindingGO:03017210.4TNNI3, TNNT2

Products for genes affiliated with Acute Myocardial Infarction

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Myocardial Infarction

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet