MCID: ACT075
MIFTS: 60

Acute Myocardial Infarction malady

Genetic diseases (common), Cardiovascular diseases categories
Download this MalaCard

Summaries for Acute Myocardial Infarction

About this section


Fully expand this MalaCard
MalaCards based summary: Acute Myocardial Infarction is related to cardiac rupture and cardiogenic shock. An important gene associated with Acute Myocardial Infarction is NPPA (natriuretic peptide A), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and A-beta Plaque Formation and APP Metabolism. The compounds dobutamine and enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and brain, and related mouse phenotypes are behavior/neurological and muscle.

Aliases & Classifications for Acute Myocardial Infarction

About this section

Acute Myocardial Infarction, Aliases & Descriptions:

Name: Acute Myocardial Infarction 30 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:9408
ICD9CM27 410.90, 410, 410.9
NCIt39 C35204
ICD1025 I21

Related Diseases for Acute Myocardial Infarction

About this section

Diseases in the Myocardial Infarction family:

acute myocardial infarction Posterior Myocardial Infarction
Myocardial Infarction, Susceptibility to, 1 Myocardial Infarction 2

Diseases related to Acute Myocardial Infarction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 288)
idRelated DiseaseScoreTop Affiliating Genes
1cardiac rupture32.3PLAT, CHKB
2cardiogenic shock32.1PIK3C2A, PLAT, NPPB
3coronary thrombosis31.7PLAT, F3
4congestive heart failure31.5TNNT2, TNNI3
5myocarditis31.4NPPB, MB, CHKB, TNNI3, TNNT2
6coronary artery vasospasm31.3AHSP, CHKB
7kawasaki disease31.2ADM, CRP, NPPB
8diabetes mellitus31.2PIK3C2A, ACE, PLAT, CRP, NPPA, NPPB
9atrioventricular block31.1PIK3C2A, NPPB
10hypertension31.0ADM, ACE, PLAT, CRP, NPPA, NPPB
11sick sinus syndrome31.0NPPA
12syndrome of inappropriate antidiuretic hormone30.9NPPA, NPPB
13rheumatic disease30.9CRP
14pericardial effusion30.9CHKB, PIK3C2A
15status asthmaticus30.8PIK3C2A
16antiphospholipid syndrome30.8PLAT, F3, SULT1A3
17neuroleptic malignant syndrome30.8PIK3C2A, CHKB, MB
18thrombocytosis30.8SERPINF2, F3, CRP
19peripheral vascular disease30.8PLAT, F3
20obesity30.8SULT1A3, FABP12, FABP3, SAA4, CRP
21thrombophilia30.7PLAT, F3, SERPINF2
22polymyositis30.7PIK3C2A, CHKB, MB
23pneumonia30.6PIK3C2A, ADM, SAA4, CRP, MB
24intermediate coronary syndrome30.6PIK3C2A, TNNT2, TNNI3, PLAT, MB
25insulin resistance30.6FABP12, FABP3, ACE, PLAT, CRP, MB
26respiratory failure30.6PIK3C2A, F3, CRP
27hypercholesterolemia30.6AHSP, SERPINF2, ACE, CRP
28acute pancreatitis30.5SULT1A3, CRP, MB
29chronic obstructive pulmonary disease30.5AHSP, CRP, MB, NPPB
30vasculitis30.5PTX3, SULT1A3, CRP
31arthritis30.3SULT1A3, SAA4, CRP, MB
32proteinuria30.2CRP, ACE, SAA4, ADM, PIK3C2A
33disseminated intravascular coagulation30.2PIK3C2A, SERPINF2, F3, PLAT, MB
34thromboembolism30.2SERPINF2, SULT1A3, F3, PLAT
35rheumatoid arthritis30.2MB, CRP, SAA4, CHKB, PTX3
36ischemia30.1PIK3C2A, AHSP, TNNT2, CTF1, NPPB, MB
37pulmonary embolism30.0SERPINF2, FABP3, F3, PLAT, NPPB
38septic shock30.0PIK3C2A, PTX3, ADM, F3, CRP, NPPB
39type 2 diabetes mellitus30.0SERPINF2, ADM, FABP12, ACE, PLAT, CRP
40vascular disease29.9CRP, PLAT, ACE, F3, SULT1A3, AHSP
41myocardial infarction29.3FABP12, FABP3, SAA4, F3, ACE, PLAT
42atherosclerosis29.1SULT1A3, SERPINF2, PTX3, AHSP, FABP12, SAA4
43coronary artery anomaly29.0CRP, MB, NPPA, NPPB, CTF1, PLAT
44cerebrovascular disease28.7SULT1A3, ADM, FABP12, FABP3, SAA4, F3
45endotheliitis11.0
46aneurysm10.9
47angina pectoris10.9
48myocardial infarction 210.9
49right bundle branch block10.8
50artery disease10.8

Graphical network of the top 20 diseases related to Acute Myocardial Infarction:



Diseases related to acute myocardial infarction

Symptoms for Acute Myocardial Infarction

About this section

Drugs & Therapeutics for Acute Myocardial Infarction

About this section

Drug clinical trials:

Search ClinicalTrials for Acute Myocardial Infarction

Search NIH Clinical Center for Acute Myocardial Infarction

Genetic Tests for Acute Myocardial Infarction

About this section

Anatomical Context for Acute Myocardial Infarction

About this section

MalaCards organs/tissues related to Acute Myocardial Infarction:

32
Heart, Endothelial, Brain, Monocytes, Testes, Bone, Neutrophil, Bone marrow, Thyroid, Prostate, Whole blood, Kidney, Skeletal muscle, Liver, Lung, Spinal cord, Myeloid, Spleen, Small intestine, T cells, Pituitary

Animal Models for Acute Myocardial Infarction or affiliated genes

About this section

MGI Mouse Phenotypes related to Acute Myocardial Infarction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2TNNI3, ADM, CHKB, FABP3, F3, ACE
2MP:00053698.1NPPB, TNNT2, TNNI3, ADM, CHKB, FABP3
3MP:00053848.0PTX3, ADM, F3, ACE, PLAT, MB
4MP:00053857.8TNNT2, TNNI3, ADM, FABP3, F3, ACE
5MP:00053977.5PIK3C2A, AHSP, PTX3, ADM, F3, ACE
6MP:00107687.4PIK3C2A, AHSP, TNNT2, TNNI3, ADM, FABP3
7MP:00053877.3PIK3C2A, AHSP, PTX3, ADM, F3, ACE
8MP:00053766.8CHKB, ADM, SERPINF2, TNNT2, PIK3C2A, FABP3

Publications for Acute Myocardial Infarction

About this section

Articles related to Acute Myocardial Infarction:

(show top 50)    (show all 2517)
idTitleAuthorsYear
1
Acute myocardial infarction in Kabuki syndrome: chance occurrence or a novel risk factor for premature atherosclerosis? (25065336)
2014
2
Reactive thrombocytosis leading to acute myocardial infarction. (24772734)
2013
3
Acute Myocardial Infarction Caused by Infective Endocarditis. (24316084)
2013
4
The Relationship of Acute Myocardial Infarction With or Without ST-Segment Elevation and Viscosity. (23742945)
2013
5
Endoscopy after acute myocardial infarction: an evaluation of safety. (24096947)
2013
6
The angiotensinogen gene M235T polymorphism and acute myocardial infarction risk: a meta-analysis of 22 studies. (23666149)
2013
7
Comparison of cancer risk associated with low-dose ionizing radiation from cardiac imaging and therapeutic procedures after acute myocardial infarction in women versus men. (23972348)
2013
8
Validity of the GRACE score for 6-month death or reinfarction after presentation with acute myocardial infarction in patients 80 years of age and older. (23965947)
2013
9
Acute myocardial infarction in patients with chronic kidney disease: how are the most vulnerable patients doing? (23903416)
2013
10
Cardiovascular outcomes using intra-aortic balloon pump in high-risk acute myocardial infarction with or without cardiogenic shock: a meta-analysis. (21335478)
2012
11
Association of platelet collagen receptor polymorphisms with premature acute myocardial infarction. (22627583)
2012
12
Diagnostic performance of high-sensitivity troponin T, myeloperoxidase, and pregnancy-associated plasma protein A assays for triage of patients with acute myocardial infarction. (21779191)
2011
13
Appraisal of the prognosis in patients with acute myocardial infarction treated with primary percutaneous coronary intervention. (19568720)
2009
14
The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. (19637097)
2009
15
Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients. (19540141)
2009
16
Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. (18997620)
2009
17
Enhanced proinflammatory response of mononuclear cells to in vitro LPS-challenge in patients with ventricular fibrillation in the setting of acute myocardial infarction. (18571935)
2008
18
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments. (17726257)
2007
19
Dynamics and source of endothelin-1 and interleukin-6 following coronary reperfusion in patients with acute myocardial infarction. (17507790)
2007
20
Glomerular filtration rate on admission independently predicts short-term in-hospital mortality after acute myocardial infarction. (16926535)
2006
21
Relationship between the mismatch of 123I-BMIPP and 201Tl myocardial single-photon emission computed tomography and autonomic nervous system activity in patients with acute myocardial infarction. (16607047)
2006
22
On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease. (16251892)
2006
23
Kinetics of chemokines in acute myocardial infarction. (15928736)
2005
24
Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy. (14965340)
2004
25
Noninvasive estimation of impaired hemodynamics for patients with acute myocardial infarction by Tei index. (15163931)
2004
26
The pro- and anti-inflammatory markers in patients with acute myocardial infarction and chronic stable angina. (15254785)
2004
27
Acute myocardial infarction probably caused by paradoxical embolus in a pregnant woman. (14966073)
2004
28
Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. (12520145)
2003
29
Pleiotropic effects of cytokines on acute myocardial infarction: G-CSF as a novel therapy for acute myocardial infarction. (12769752)
2003
30
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
31
Acute myocardial infarction: a rare complication of protein C deficiency. (11294179)
2001
32
Soluble P-selectin and the success of thrombolysis in acute myocardial infarction. (11461745)
2001
33
Biochemical markers in the management of suspected acute myocardial infarction in the emergency department. (11310455)
2001
34
Survival outcomes 1 year after reperfusion therapy with either alteplase or reteplase for acute myocardial infarction: results from the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO) III Trial. (11023929)
2000
35
Intracranial hemorrhage rates and effect of immediate beta-blocker use in patients with acute myocardial infarction treated with tissue plasminogen activator. Participants in the National Registry of Myocardial Infarction-2. (11078295)
2000
36
Baseline platelet aggregation and major receptor expression predict subsequent activity following thrombolysis for acute myocardial infarction. (10816061)
2000
37
Prehospital management of acute myocardial infarction: Electrocardiogram acquisition and interpretation, and thrombolysis by prehospital care providers. (9852937)
1998
38
Plasma levels of adrenomedullin in patients with acute myocardial infarction. (9536921)
1998
39
Elevated plasma levels of interleukin-1 receptor antagonist and interleukin-10 in patients with acute myocardial infarction. (9085939)
1997
40
Effects of ramipril and spironolactone on ventricular remodeling after acute myocardial infarction: randomized and double-blind study]. (9515282)
1997
41
Captopril reduced plasminogen activator inhibitor activity in patients with acute myocardial infarction. (9152782)
1997
42
Evolution of haptoglobin concentration in serum during the early phase of acute myocardial infarction. (9056748)
1997
43
The prognostic value of predischarge quantitative two-dimensional echocardiographic measurements and the effects of early lisinopril treatment on left ventricular structure and function after acute myocardial infarction in the GISSI-3 Trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. (8922912)
1996
44
Clinical benefit of angiotensin converting enzyme inhibition after acute myocardial infarction: myocardial reperfusion revisited. (9023710)
1996
45
Brazilian study with alteplase in acute myocardial infarction--EBRALT]. (8554497)
1995
46
Urinary albumin excretion increases during an acute myocardial infarct especially in patients who develop heart failure]. (7498633)
1995
47
The use of myoglobin for the early diagnosis of reperfusion in acute myocardial infarct]. (8087811)
1994
48
Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors. (8429112)
1993
49
Cardiac rupture, a clinically predictable complication of acute myocardial infarction: report of 70 cases with clinicopathologic correlations. (8354804)
1993
50
Serum elastinolytic activity and blood lipids in various clinical forms of arteriosclerosis and in acute myocardial infarct]. (2047114)
1991

Variations for Acute Myocardial Infarction

About this section

Expression for genes affiliated with Acute Myocardial Infarction

About this section
Expression patterns in normal tissues for genes affiliated with Acute Myocardial Infarction

Search GEO for disease gene expression data for Acute Myocardial Infarction.

Pathways for genes affiliated with Acute Myocardial Infarction

About this section

Pathways related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1NPPB, NPPA
210.0PLAT, ACE
39.9SERPINF2, PLAT
49.8CTF1, NPPB, NPPA
5
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.7TNNT2, TNNI3, ACE
6
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.5SERPINF2, F3, PLAT
7
Show member pathways
9.5PLAT, F3, SERPINF2
8
Show member pathways
thioredoxin pathway37
9.5CRP, PLAT, SAA4

Compounds for genes affiliated with Acute Myocardial Infarction

About this section

Compounds related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1dobutamine44 28 50 1113.0PLAT, NPPA, NPPB, CHKB
2enalaprilat449.9ACE, PLAT, NPPA, NPPB
3fosinopril44 1110.9NPPB, NPPA, CRP, ACE
4quinapril44 50 1111.9CRP, ACE, PLAT, NPPA
5omapatrilat449.8ADM, ACE, PLAT, NPPA
6perindopril44 50 1111.7ACE, PLAT, CRP, NPPA, NPPB
7ramipril44 1110.7ACE, CRP, NPPA, NPPB
8spec-t449.6ADM, CHKB, PLAT, NPPA, NPPB
9thallium449.6PIK3C2A, NPPB, FABP3, CHKB
10clopidogrel44 50 24 1112.6CHKB, F3, ACE, PLAT, CRP
11tirofiban44 1110.6NPPB, CRP, PLAT, F3
128-bromo cgmp449.4ADM, NPPA, AHSP, NPPB
13losartan44 50 28 1112.3ADM, NPPB, NPPA, CRP, ACE, PLAT
14kininogen449.3PLAT, SERPINF2, ACE, F3, NPPA
15mibg449.3NPPA, ADM, PIK3C2A, FABP3, NPPB
16captopril44 61 50 28 1113.2F3, AHSP, ADM, ACE, NPPB, NPPA
17fluvastatin44 50 28 1112.1ACE, MB, CRP, PIK3C2A, CHKB, PLAT
18atorvastatin44 50 28 24 1113.1PIK3C2A, NPPB, CRP, ACE, PLAT, CHKB
19aprotinin44 1110.0PLAT, NPPB, F3, SERPINF2, MB
20citrate448.9FABP3, F3, CRP, MB, CHKB, PIK3C2A
21pravastatin44 50 28 24 1112.9ACE, CRP, CHKB, PIK3C2A, NPPB
22thyroxine44 249.8PIK3C2A, CHKB, PLAT, MB, NPPB, SERPINF2
23catecholamine448.8NPPA, CHKB, PIK3C2A, SULT1A3, ADM, NPPB
24isoproterenol44 119.7PLAT, NPPA, NPPB, PIK3C2A, AHSP, ADM
25sodium nitroprusside448.7ADM, NPPB, PIK3C2A, NPPA, MB, PLAT
26aspirin44 50 28 2411.6ACE, CHKB, SULT1A3, AHSP, PLAT, CRP
27acetylcholine44 50 28 24 1112.5NPPB, MB, AHSP, PIK3C2A, ADM, ACE
28endotoxin448.4AHSP, F3, SERPINF2, ADM, CHKB, SAA4
29prostaglandin f2alpha448.4ADM, FABP12, CRP, MB, SAA4, AHSP
30potassium44 24 1110.3NPPA, CHKB, ADM, TNNI3, PIK3C2A, ACE
31uric acid44 249.2CHKB, FABP12, NPPB, CRP, SAA4, PIK3C2A
32prostacyclin448.1NPPB, NPPA, CRP, PLAT, ACE, F3
33testosterone44 61 24 1111.0MB, NPPB, NPPA, CRP, CHKB, ADM
34vegf448.0CHKB, F3, CRP, MB, PIK3C2A, SERPINF2
35nitroglycerin44 118.9PLAT, CRP, NPPA, NPPB, ACE, F3
36epinephrine44 24 119.9ADM, SERPINF2, PIK3C2A, CHKB, F3, SULT1A3
37arginine447.8PIK3C2A, SERPINF2, NPPA, MB, CHKB, ADM
38ptca447.8PIK3C2A, TNNT2, SERPINF2, ADM, CHKB, SAA4
39heparin44 28 24 1110.6NPPB, SULT1A3, F3, MB, CHKB, SERPINF2
40norepinephrine44 24 119.6ACE, PIK3C2A, SULT1A3, ADM, CHKB, FABP3
41homocysteine44 248.6PIK3C2A, AHSP, SULT1A3, ADM, SAA4, F3
42fibrinogen447.6AHSP, SERPINF2, CHKB, SAA4, F3, PLAT
43fatty acid447.5CHKB, FABP12, ADM, NPPB, FABP3, PIK3C2A
44lactate447.4MB, FABP12, PIK3C2A, FABP3, CRP, NPPB
45alanine447.3SERPINF2, PIK3C2A, TNNT2, CHKB, F3, MB
46glucose446.9CRP, PIK3C2A, AHSP, ADM, NPPB, PLAT
47lipid446.4NPPB, CRP, ACE, SAA4, FABP12, ADM
48calcium44 50 24 119.4TNNI3, CRP, PIK3C2A, AHSP, SERPINF2, FABP12
49cholesterol44 28 24 118.8PIK3C2A, AHSP, PTX3, FABP3, CRP, PLAT
50creatinine445.0PIK3C2A, CRP, MB, NPPA, NPPB, PLAT

GO Terms for genes affiliated with Acute Myocardial Infarction

About this section

Cellular components related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:0058619.9TNNI3, TNNT2
2extracellular spaceGO:0056157.6SERPINF2, ADM, F3, ACE, PLAT, CRP
3extracellular regionGO:0055767.1CTF1, PTX3, SERPINF2, ADM, SAA4, ACE

Biological processes related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.2NPPB, NPPA
2negative regulation of ATPase activityGO:03278010.1TNNT2, TNNI3
3regulation of vasodilationGO:04231210.1NPPB, ACE
4receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB
5regulation of blood pressureGO:00821710.0NPPB, NPPA, ACE
6regulation of blood vessel sizeGO:05088010.0NPPB, NPPA
7response to insulinGO:0328689.9NPPA, FABP3, ADM
8opsonizationGO:0082289.8CRP, PTX3
9heart developmentGO:0075079.6MB, ADM, TNNI3
10fibrinolysisGO:0427309.6PLAT, SERPINF2
11acute-phase responseGO:0069539.5SERPINF2, SAA4, CRP
12response to hypoxiaGO:0016669.5NPPA, MB, CRP, PLAT, ADM

Molecular functions related to Acute Myocardial Infarction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.7NPPB, NPPA, ADM
2troponin C bindingGO:0301729.6TNNI3, TNNT2

Products for genes affiliated with Acute Myocardial Infarction

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Acute Myocardial Infarction

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet