MCID: ACT076
MIFTS: 49

Acute Myocarditis malady

Cardiovascular diseases category

Summaries for Acute Myocarditis

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32MalaCards
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MalaCards: Acute Myocarditis is related to myocarditis and acute myocardial infarction. An important gene associated with Acute Myocarditis is TNC (tenascin C), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Regulation by c-FLIP. The compounds cycloheximide and ivig have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and tonsil, and related mouse phenotypes are vision/eye and liver/biliary system.

Aliases & Classifications for Acute Myocarditis

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

acute myocarditis 8 44 60


External Ids:

Disease Ontology8 DOID:3951
ICD9CM27 422.90, 422
NCIt39 C35206
ICD1025 I40

Related Diseases for Acute Myocarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis31.9TXN
2acute myocardial infarction30.9ACE, TXN, TNC, FABP3, FGA, ABCB7
3myocardial infarction30.9PROM1, ABCB7, FABP3, TNC, FGA, PLAT
4dilated cardiomyopathy30.7FGA, FABP3, ACE, TXN
5influenza30.4TXN
6lupus erythematosus30.4APOH, CD70
7systemic lupus erythematosus30.4FAS, APOH, FASLG, FGA, CD70
8pneumonia30.3FGA, TXN
9acute pancreatitis29.9ABCB7
10hepatitis b29.9TXN, ABCB7
11hepatitis29.9FASLG, TXN, FAS
12pulmonary embolism29.9FABP3, PLAT, FGA, APOH
13atrioventricular block10.5
14pericarditis10.3
15eosinophilia10.2
16coronary artery vasospasm10.1
17hypertrophic cardiomyopathy10.1
18diastolic heart failure10.1
19acute orbital inflammation10.1
20malaria10.1
21restrictive cardiomyopathy10.1
22pheochromocytoma10.1
23arthritis10.0TXN
24hyperthyroidism10.0SDHA
25thyroiditis10.0FASLG
26dementia10.0FABP3
27cryoglobulinemia10.0APOH
28bronchopulmonary dysplasia10.0TXN
29retinal artery occlusion10.0APOH
30cataract10.0TXN
31connective tissue disease10.0APOH
32lupus nephritis10.0APOH
33retinal vein occlusion10.0APOH
34portal vein thrombosis10.0ABCB7
35migraine10.0APOH
36antithrombin iii deficiency10.0APOH
37primary pulmonary hypertension10.0FGA
38thrombophlebitis10.0APOH
39pancreatic cancer10.0FASLG, TNC
40endometrial carcinoma10.0TNC
41myeloid leukemia10.0FAS
42multiple sclerosis10.0TNC, FASLG
43intermediate coronary syndrome10.0PLAT
44obesity10.0ABCB7, FABP3
45coronary thrombosis10.0PLAT
46astrocytoma10.0TNC, FASLG
47thyroid cancer10.0TNC
48oral cancer10.0TNC, FASLG
49medulloblastoma10.0PROM1
50alzheimer's disease10.0FABP3, TXN

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Clinical Features for Acute Myocarditis

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Drugs & Therapeutics for Acute Myocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Myocarditis

Drug clinical trials:

Search ClinicalTrials for Acute Myocarditis

Search NIH Clinical Center for Acute Myocarditis

Search CenterWatch for Acute Myocarditis

Genetic Tests for Acute Myocarditis

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Anatomical Context for Acute Myocarditis

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32MalaCards
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MalaCards organs/tissues related to Acute Myocarditis:

32
Heart, T cells, Tonsil, Liver, Cardiac myocytes, Kidney, Pancreas

Animal Models for Acute Myocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Myocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.6PLAT, FABP3
2MP:00053708.1ABCB7, FGA, FABP3, FASLG, FAS, ACE
3MP:00053767.5TNC, APOH, FABP3, FGA, ABCB7, PLAT
4MP:00053857.3ACE, FAS, FASLG, FABP3, PROM1, FGA
5MP:00107686.0TXN, APOH, FAS, FASLG, FABP3, PROM1

Publications for Acute Myocarditis

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50PubMed
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Articles related to Acute Myocarditis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Effects of carvedilol treatment on cardiac cAMP response element binding protein expression and phosphorylation in acute coxsackievirus B3-induced myocarditis. (24225056)
2013
2
Role of cardiovascular magnetic resonance imaging (CMR) in the diagnosis of acute and chronic myocarditis. (23076423)
2013
3
Acute viral myocarditis: current concepts in diagnosis and treatment. (23662385)
2013
4
Acute myocarditis and ventricular fibrillation as initial presentation of pediatric systemic lupus erythematosus. (22119942)
2013
5
Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: an observational study. (22243770)
2012
6
Diagnostic and prognostic biomarkers in acute myocarditis. Interleukin-10. (22941230)
2012
7
Demographics, trends, and outcomes in pediatric acute myocarditis in the United States, 2006 to 2011. (22828827)
2012
8
Gadolinium chelate kinetics in cardiac MR imaging of myocarditis: comparison to acute myocardial infarction and impact on late gadolinium enhancement. (21808201)
2011
9
Acute myocarditis demonstrated on CT coronary angiography with MRI correlation. (21586739)
2011
10
Eosinophilic myocarditis mimicking acute coronary syndrome secondary to idiopathic hypereosinophilic syndrome: a case report. (20181108)
2010
11
Th17 cells facilitate the humoral immune response in patients with acute viral myocarditis. (20012175)
2010
12
Cardiac magnetic resonance in acute myocarditis and dilated cardiomyopathy. (19396051)
2009
13
Coagulative hemostasis in patients with acute viral myocarditis]. (19145820)
2008
14
Naloxone, an opiate receptor antagonist, ameliorates acute experimental autoimmune myocarditis by reducing cytotoxic activities. (19033824)
2008
15
Acute myocarditis during anesthesia after rubella infection. (18950357)
2008
16
Diagnostic value of ECG-gated multidetector computed tomography in the early phase of suspected acute myocarditis. A preliminary comparative study with cardiac MRI. (16953372)
2007
17
Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema. (17599815)
2007
18
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
19
Should Angiotensin-converting enzyme inhibitors be continued over the long term in patients whose left ventricular ejection fraction normalizes after an episode of acute myocarditis?]. (17144995)
2006
20
Acute heart failure due to fulminant and giant cell myocarditis. (17149678)
2006
21
Recovery of acute myocarditis with biventricular assist device in infant. (16274783)
2005
22
Hypereosinophilic syndrome associated with acute necrotizing myocarditis and cardiomyopathy. (16258779)
2005
23
Bridge-to-recovery from acute myocarditis in a 12-year-old child. (15153152)
2004
24
Churg-Strauss syndrome with myocarditis manifesting as acute myocardial infarction with cardiogenic shock: case report and review of the literature. (14532945)
2003
25
Acute myocarditis in a patient with eosinophilia and pulmonary infiltrates. (11875604)
2002
26
Etiology, evaluation, and management of acute myocarditis. (11209147)
2001
27
Predictors of disease course in patients with acute myocarditis. (11104740)
2000
28
Echocardiographic observation of acute myocarditis with systemic lupus erythematosus. (10716530)
2000
29
Intrapericardial yolk sac tumor associated with acute myocarditis. (10086513)
1999
30
Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. (7635939)
1995
31
Acute myocarditis presenting as acute myocardial infarction. (7744630)
1995
32
Successful treatment of acute myocarditis using extracorporeal membrane oxygenation. (8428487)
1993
33
Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3. (1650300)
1991
34
Insulin administration reverses the metabolic and electrocardiographic changes in acute myocarditis induced by Indian red scorpion (Buthus tamulus) venom in experimental dogs. (2190913)
1990
35
Acute myocarditis causing fatal ventricular arrhythmia in treated polymyositis. (3179631)
1988
36
Successful management of acute myocarditis with biventricular assist devices and cardiac transplantation. (3041794)
1988
37
Acute myocarditis associated with transient marked myocardial thickening and complete atrioventricular block. (6540151)
1984
38
24-Hour electrocardiographic recordings in mild acute infectious myocarditis. (6742766)
1984
39
Left ventricular asynergy in acute myocarditis. Simulation of acute myocardial infarction. (6887465)
1983
40
Comparative analysis of clinical features between acute myocarditis and chronic myocarditis including postmyocarditic cardiomegaly. (6447231)
1980
41
Complete atrioventricular heart block secondary to acute myocarditis requiring intracardiac pacing. (5539777)
1971
42
Five-year follow-up study of cases suggestive of acute myocarditis. (5957685)
1966
43
EXPERIMENTAL ACUTE MYOCARDITIS. (14214811)
1964
44
A unusual type of intermittent A-V dissociation in acute rheumatic myocarditis. (13707052)
1961
45
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
46
Sonvelographic recording of murmurs during acute myocarditis. (13207010)
1954
47
Transient electrocardiographic changes simulating an acute myocarditis in serum sickness. (13065994)
1953
48
Acute interstitial myocarditis associated with carcinoma of the body of the pancreas; report of a case. (14911037)
1952
49
Acute rheumatic myocarditis. (21000390)
1946
50
A CASE OF DIPHTHERIAL ACUTE MYOCARDITIS STUDIED BY MEANS OF THE PORTABLE ELECTRO-CARDIOGRAPH. (20775498)
1930

Genetic Variations for Acute Myocarditis

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Expression for genes affiliated with Acute Myocarditis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

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Sources:
52R&D Systems, 53Reactome, 12EMD Millipore, 55SinoBiological, 4Cell Signaling Technology
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Compounds for genes affiliated with Acute Myocarditis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acute Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5FASLG
2ivig4410.5APOH
3(glc)44410.1FAS, FASLG
411-dehydrothromboxane b24410.0FGA, APOH
5an 69449.9FGA, ACE
6desirudin449.9FGA, PLAT
7atpo44 2810.8FAS, FASLG, APOH
8fibrinopeptide a449.8FGA, PLAT
9batroxobin449.8FGA, PLAT
10ancrod449.8PLAT, FGA
11palmitate449.8TXN
12delapril449.7ACE, PLAT
13bivalirudin44 1110.7FGA, PLAT
14manidipine449.7PLAT, ACE
15argatroban44 1110.7FGA, PLAT
16selenodiglutathione449.6TXN, FAS
17omapatrilat449.6PLAT, ACE
18glutamate449.6PLAT, ABCB7, APOH
19ticlopidine44 1110.6APOH, FGA, PLAT
20ptca449.6APOH, PLAT, FGA
21thromboxane44 2410.5PLAT, APOH, FGA
22p002449.5FABP3, PLAT, APOH, TNC
23thromboxane a244 2410.4APOH, FGA, PLAT
24enalaprilat449.4PLAT, ACE
25ppack449.4FGA, PLAT
26kininogen449.4ACE, APOH, PLAT
27glucose449.3PLAT, FASLG, APOH, FABP3
28quinapril44 1110.3PLAT, ACE
29suberoylanilide hydroxamic acid449.3FASLG, TXN, FAS
30daunorubicin44 49 1111.2FAS, FASLG, TXN
31p003449.2FABP3, FASLG, APOH, TNC, PLAT
32mitomycin c449.2TXN, FASLG, FAS
33heparin44 28 11 2412.1ABCB7, APOH, FAS, FASLG, FGA
34warfarin44 49 11 2412.1ACE, APOH, FGA, PLAT
35prostacyclin449.0PLAT, ACE, APOH, FGA
36fibrinogen449.0PLAT, TNC, APOH, ABCB7, FGA
37progesterone44 59 28 11 2413.0FASLG, PLAT, ABCB7, TNC, APOH
38paraffin448.9FAS, TNC, FASLG, PLAT
39sodium nitroprusside448.8PLAT, FASLG, FAS
40pge1448.8PLAT, TXN, APOH, FGA
41nitric oxide44 11 2410.7FAS, FASLG, APOH, ACE, ABCB7
42aspirin44 49 28 2411.6ACE, PLAT, APOH, FGA, FAS
43vegf448.6FAS, FASLG, TNC, APOH, TXN
44ascorbic acid44 249.5TXN, TNC, FAS, FASLG, PLAT
45actinomycin d448.4PLAT, FAS, TNC, TXN, FASLG
46lipid448.4TNC, APOH, FABP3, PROM1, FGA, ABCB7
47aspartate448.3PLAT, ABCB7, FASLG, TXN, FAS
48cholesterol44 28 11 2411.2APOH, FGA, ABCB7, PLAT, ACE, FABP3
49lactate448.1FGA, FABP3, ABCB7, TXN, APOH, FASLG
50creatinine447.0APOH, TXN, TNC, FABP3, FGA, ABCB7

GO Terms for genes affiliated with Acute Myocarditis

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16Gene Ontology
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Cellular components related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.3PLAT, APOH, TNC
2external side of plasma membraneGO:0098978.8ACE, FGA, FASLG, FAS
3cell surfaceGO:0099868.4APOH, PROM1, FGA, PLAT
4extracellular regionGO:0055767.0ACE, TXN, TNC, FAS, FASLG, FGA
5extracellular spaceGO:0056157.0APOH, PROM1, CD70, FGA, PLAT, ACE

Biological processes related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.8FASLG, FAS
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.7FASLG, FAS
3plasminogen activationGO:0316399.4APOH, PLAT
4cellular response to hyperoxiaGO:0714559.2TXN, FAS
5cell-cell signalingGO:0072678.3TXN, TNFSF8, FASLG, CD70
6signal transductionGO:0071657.8TXN, TNFSF8, FAS, FASLG, CD70, FGA

Molecular functions related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.4CD70, FASLG, TNFSF8
2cytokine activityGO:0051259.4CD70, FASLG, TNFSF8
3receptor bindingGO:0051028.7TNFSF8, FASLG, CD70, FGA
4protein bindingGO:0055155.5TXN, APOH, FAS, FASLG, FABP3, PROM1

Products for genes affiliated with Acute Myocarditis

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Sources for Acute Myocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet