MCID: ACT076
MIFTS: 42

Acute Myocarditis malady

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Acute Myocarditis

Aliases & Descriptions for Acute Myocarditis:

Name: Acute Myocarditis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD10 33 I40 I40.9
ICD9CM 35 422 422.90
NCIt 47 C35206
UMLS 69 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to lupus erythematosus and myocarditis. An important gene associated with Acute Myocarditis is CD40 (CD40 Molecule), and among its related pathways/superpathways are Allograft rejection and Toll-like Receptor Signaling Pathway. The drugs Ferrosoferric Oxide and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and immune system

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
id Related Disease Score Top Affiliating Genes
1 lupus erythematosus 29.4 ACE TNNI3
2 myocarditis 10.8
3 giant cell myocarditis 10.5
4 myocardial infarction 10.2
5 cardiomyopathy 10.2
6 midline interhemispheric variant of holoprosencephaly 10.2 FAS FASLG
7 skeletal muscle cancer 10.2 FAS FASLG
8 parasitic ichthyosporea infectious disease 10.2 CD40 CD86
9 leber congenital amaurosis 10.1 FAS TNC
10 macrogyria, pseudobulbar palsy and mental retardation 10.1 FAS FASLG
11 fiedler's myocarditis 10.1
12 cd3zeta deficiency 10.1 CD86 TNFSF8
13 anauxetic dysplasia 10.1 FAS FASLG
14 acute myocardial infarction 10.1
15 mixed cell type cancer 10.1 FAS FASLG
16 breast adenomyoepithelioma 10.1 FAS FASLG
17 diabetes mellitus, insulin-dependent, 12 10.1 CD40 FAS FASLG
18 congestive heart failure 10.0 CD40 CD86 FAS
19 dilated cardiomyopathy 10.0
20 pseudo-meigs syndrome 10.0 FAS FASLG
21 atrioventricular block 10.0
22 septic myocarditis 10.0
23 mesenteric lymphadenitis 9.9 ACE CUX2
24 influenza 9.9
25 aneurysm 9.9
26 skin conditions 9.8 ACE FAS FASLG
27 systemic lupus erythematosus 9.8
28 cardiogenic shock 9.8
29 pericarditis 9.8
30 microscopic breast papilloma 9.7 ACE CD40 CD86 TNNI3
31 pneumonia 9.7
32 pheochromocytoma 9.6
33 malaria 9.6
34 cardiac tamponade 9.6
35 coronary artery vasospasm 9.6
36 parametritis 9.6
37 myopathy 9.6
38 diastolic heart failure 9.6
39 naxos disease 9.5
40 kawasaki disease 9.5
41 crohn's disease 9.5
42 dengue hemorrhagic fever 9.5
43 hepatitis 9.5
44 hepatitis b 9.5
45 ulcerative colitis 9.5
46 chikungunya 9.5
47 japanese spotted fever 9.5
48 third-degree atrioventricular block 9.5
49 colitis 9.5
50 atrial fibrillation 9.5

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 ACE FAS TNFSF8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 ACE CD40 FAS FASLG TNFSF8

MGI Mouse Phenotypes related to Acute Myocarditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 ACE CD40 CD86 DMGDH FAS FASLG

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ferrosoferric Oxide Phase 2, Phase 3
2 Hematinics Phase 2, Phase 3
3 Parenteral Nutrition Solutions Phase 2, Phase 3
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Adrenergic Agents Phase 2, Phase 3
6 Adrenergic Antagonists Phase 2, Phase 3
7 Adrenergic beta-Antagonists Phase 2, Phase 3
8 Antirheumatic Agents Phase 2, Phase 3
9 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
10 Neurotransmitter Agents Phase 2, Phase 3
11
Iron Approved Phase 2 7439-89-6 23925
12 Antioxidants
13 Protective Agents
14 HIV Protease Inhibitors
15 Matrix Metalloproteinase Inhibitors
16
protease inhibitors
17 TIMP1 protein, human
18 Tissue Inhibitor of Metalloproteinase-1
19 Tissue Inhibitor of Metalloproteinases
20 cadexomer iodine
21
Iodine 7553-56-2 807

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3
2 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Not yet recruiting NCT03018834 Phase 2, Phase 3
3 IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioN Unknown status NCT01995799 Phase 2
4 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
5 International Myocarditis Registry Unknown status NCT01307735
6 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
7 Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients Unknown status NCT01089036
8 Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death Unknown status NCT01919983
9 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
10 CMR in Patients With Myocarditis Completed NCT01962584
11 Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis Completed NCT00693134
12 Detection of Enterovirus RNA in Atheromatous Lesions Completed NCT00674531
13 German Centre for Cardiovascular Research Cardiomyopathy Register Recruiting NCT02187263
14 Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary Atherosclerosis Recruiting NCT02655718
15 Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRI Recruiting NCT02318498
16 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Recruiting NCT02527330
17 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
18 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Not yet recruiting NCT02905721
19 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Not yet recruiting NCT02717143
20 Cardiac and Laboratory Findings in Patients With Systemic Lupus Erythematosus Not yet recruiting NCT03179046
21 Multicenter Cohort of STEMI Patients Not yet recruiting NCT03070496

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

39
Heart, T Cells, Liver, Cardiac Myocytes, Myeloid, Kidney

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 459)
id Title Authors Year
1
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
2
Established and novel treatment options in acute myocarditis, with or without heart failure. ( 27858465 )
2017
3
Incremental value of cardiac deformation analysis in acute myocarditis: a cardiovascular magnetic resonance imaging study. ( 27100527 )
2016
4
Comprehensive Cardiac Magnetic Resonance for Short-Term Follow-Up in Acute Myocarditis. ( 27436306 )
2016
5
Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis. ( 27913009 )
2016
6
Acute Myocarditis With Very High Troponin but No Ventricular Dysfunction. ( 27356633 )
2016
7
Cardiac MRI and acute myocarditis. ( 28062736 )
2016
8
Usefulness of Late Iodine Enhancement on Spectral CT in Acute Myocarditis. ( 28017385 )
2016
9
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii. ( 27085128 )
2016
10
Arrhythmic risk prediction of acute myocarditis presenting with life-threatening ventricular tachyarrhythmias. ( 27038726 )
2016
11
Left ventricular end-diastolic dimension as a predictive factor of outcomes in children with acute myocarditis. ( 27225897 )
2016
12
Myocardial fibrosis detected with Gadolinium Delayed Enhancement in Cardiac Magnetic Resonance Imaging and Ventriculoarterial Coupling alterations in patients with Acute Myocarditis. ( 28081949 )
2016
13
Persistent Atrial Standstill in Acute Myocarditis. ( 26897154 )
2016
14
Clinicodemographic features and outcome of acute myocarditis in children admitted at tertiary care hospital. ( 27400295 )
2016
15
Immunosuppressive Therapy and Interferon-1I^ in Acute Myocarditis. ( 27514623 )
2016
16
Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus. ( 26922692 )
2016
17
An autopsy case of cardiac tamponade caused by a ruptured ventricular aneurysm associated with acute myocarditis. ( 26832375 )
2016
18
Reply: Nondilated Left Ventricle as an Adding Clue Helping Discrimination Between Acute Myocarditis From OtherA Cardiomyopathies. ( 27737751 )
2016
19
Veno-veno-arterial ECMO support for acute myocarditis combined with ARDS: a case report. ( 26847501 )
2016
20
The Prognostic Role of QTc Interval in Acute Myocarditis. ( 27122953 )
2016
21
Acute respiratory distress syndrome and acute myocarditis developed in a previously healthy adult with influenza B. ( 26728359 )
2016
22
Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis. ( 27472894 )
2016
23
Prognostic value of the infarct- and non-infarct like patterns and cardiovascular magnetic resonance parameters on long-term outcome of patients after acute myocarditis. ( 27035605 )
2016
24
Acute Myocarditis and ST-Segment Elevation. ( 27742420 )
2016
25
A Case of Thiopurine-Induced Acute Myocarditis in a Patient with Ulcerative Colitis. ( 27766449 )
2016
26
A unique association of arrhythmogenic right ventricular dysplasia and acute myocarditis, as assessed by cardiac MRI: a case report. ( 27871237 )
2016
27
Usefulness of Subepicardial Hyperemia on Contrast-Enhanced First-Pass Magnetic Resonance Perfusion Imaging for Diagnosis of Acute Myocarditis. ( 27296557 )
2016
28
Unusual Presentation of Dengue Fever: A child with acute myocarditis. ( 26909198 )
2016
29
Role of 18F-Fluorodeoxyglucose/Positron Emission Tomography Imaging to Demonstrate Resolution of Acute Myocarditis. ( 27923584 )
2016
30
Noninvasive imaging in acute myocarditis. ( 26731291 )
2016
31
Relationship between T-wave inversion and transmural myocardial edema as evidenced by cardiac magnetic resonance in patients with clinically suspected acute myocarditis: clinical and prognostic implications. ( 27178316 )
2016
32
Value of novel cardiac magnetic resonance indices for the diagnosis of acute myocarditis: Left ventricular mechanics and parametric mapping imaging. ( 27584565 )
2016
33
Improving outcomes of acute myocarditis in children. ( 26588165 )
2016
34
Nondilated Left Ventricle as an Adding Clue Helping Discrimination Between Acute Myocarditis From Other Cardiomyopathies. ( 27737750 )
2016
35
Acute myocarditis with normal wall motion detected with 2D speckle tracking echocardiography. ( 27249814 )
2016
36
Diagnostic implications of magnetic resonance feature tracking derived myocardial strain parameters in acute myocarditis. ( 26724669 )
2016
37
Diagnosis of acute myocarditis with dual source cardiac tomography. ( 25464460 )
2015
38
Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity. ( 26339812 )
2015
39
Acute myocardial infarction or acute myocarditis? Discharge registry-based study of likelihood and associated features in hospitalised patients. ( 26009575 )
2015
40
Acute Myocarditis and Myopathy as Presenting Manifestations of Human Immunodeficiency Virus Infection. ( 26394500 )
2015
41
Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. ( 26476398 )
2015
42
Acute Myocarditis in a Patient with Newly Diagnosed Granulomatosis with Polyangiitis. ( 26770838 )
2015
43
Extracorporeal membrane oxygenation for the support of adults with acute myocarditis. ( 25738858 )
2015
44
Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature. ( 26622337 )
2015
45
Mapping tissue inhomogeneity in acute myocarditis: a novel analytical approach to quantitative myocardial edema imaging by T2-mapping. ( 26700020 )
2015
46
Acute Myocarditis Diagnosed by Layer-Specific 2D Longitudinal Speckle Tracking Analysis. ( 26343232 )
2015
47
Lights and shadows of cardiac magnetic resonance imaging in acute myocarditis. ( 26555392 )
2015
48
Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis. ( 26002282 )
2015
49
Myocardial oedema in acute myocarditis detected by echocardiographic 2D myocardial deformation analysis. ( 26588987 )
2015
50
Cardiovascular magnetic resonance predictors of clinical outcome in patients with suspected acute myocarditis. ( 26318624 )
2015

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 CD40 CD86 FAS FASLG
2
Show member pathways
12.33 ACE CD40 CD86 FAS FASLG
3
Show member pathways
12.09 CD40 FAS FASLG TNFSF8
4 11.12 FAS FASLG
5
Show member pathways
11.06 FAS FASLG
6 10.98 ACE CD40
7 10.95 FAS FASLG
8 10.9 CD40 CD86 TNFSF8
9 10.89 CD40 CD86
10
Show member pathways
10.85 CD40 FAS FASLG TNFSF8

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD40 CD86 FAS FASLG
2 external side of plasma membrane GO:0009897 9.02 ACE CD40 CD86 FAS FASLG

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.72 CD40 FAS TNC
2 immune response GO:0006955 9.65 CD40 CD86 FAS FASLG TNFSF8
3 extrinsic apoptotic signaling pathway GO:0097191 9.56 FAS FASLG
4 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.54 FAS FASLG
5 apoptotic signaling pathway GO:0097190 9.54 CD40 FAS FASLG
6 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.52 FAS FASLG
7 B cell activation GO:0042113 9.51 CD40 CD86
8 response to interferon-gamma GO:0034341 9.49 CD40 CD86
9 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.48 FAS FASLG
10 heart contraction GO:0060047 9.46 ACE TNNI3
11 response to lipopolysaccharide GO:0032496 9.46 CD40 CD86 FAS FASLG
12 positive regulation of endothelial cell apoptotic process GO:2000353 9.43 CD40 FASLG
13 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.4 FAS FASLG
14 necroptotic signaling pathway GO:0097527 9.32 FAS FASLG
15 inflammatory cell apoptotic process GO:0006925 8.96 FAS FASLG
16 tumor necrosis factor-mediated signaling pathway GO:0033209 8.92 CD40 FAS FASLG TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.33 CD40 CD86 FAS
2 tumor necrosis factor receptor binding GO:0005164 8.96 FASLG TNFSF8
3 tumor necrosis factor-activated receptor activity GO:0005031 8.62 CD40 FAS

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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