MCID: ACT076
MIFTS: 46

Acute Myocarditis malady

Cardiovascular diseases, Rare diseases categories

Summaries for Acute Myocarditis

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MalaCards based summary: Acute Myocarditis is related to myocarditis and acute myocardial infarction. An important gene associated with Acute Myocarditis is TNC (tenascin C), and among its related pathways are FAS (CD95) signaling pathway and African trypanosomiasis. The compounds (glc)4 and procainamide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver.

Aliases & Classifications for Acute Myocarditis

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 29ICD9CM, 40NCIt, 27ICD10
See all sources

Acute Myocarditis, Aliases & Descriptions:

Name: Acute Myocarditis 10 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:3951
ICD9CM29 422.90, 422
NCIt40 C35206
ICD1027 I40

Related Diseases for Acute Myocarditis

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Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis32.1TXN
2acute myocardial infarction30.9ACE, TXN, TNC
3lupus erythematosus30.6CD70, APOH
4systemic lupus erythematosus30.5APOH, FAS, FASLG, CD70
5hepatitis30.0TXN, FAS, FASLG
6myocardial infarction10.7
7dilated cardiomyopathy10.6
8atrioventricular block10.5
9influenza10.4
10aneurysm10.4
11cardiogenic shock10.4
12pericarditis10.3
13eosinophilia10.3
14pneumonia10.3
15pheochromocytoma10.2
16malaria10.2
17coronary artery vasospasm10.2
18hypertrophic cardiomyopathy10.2
19diastolic heart failure10.2
20acute orbital inflammation10.2
21uveitis10.0ACE
22systemic scleroderma10.0ACE
23retinal artery occlusion10.0APOH
24mesothelioma10.0TXN, TNC
25naxos disease10.0
26kawasaki disease10.0
27crohn's disease10.0
28dengue hemorrhagic fever10.0
29hepatitis b10.0
30acute pancreatitis10.0
31third-degree atrioventricular block10.0
32fiedler's myocarditis10.0
33rubella10.0
34cardiac tamponade10.0
35neuronitis10.0
36appendicitis10.0
37bullous pemphigoid10.0
38parotitis10.0
39churg-strauss syndrome10.0
40chikungunya10.0
41japanese spotted fever10.0
42mumps10.0
43erysipelas10.0
44atopic dermatitis10.0
45cerebritis10.0
46chagas disease10.0
47lateral myocardial infarction10.0
48adult-onset still's disease10.0
49amyloidosis10.0
50dermatitis10.0

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Symptoms for Acute Myocarditis

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Drugs & Therapeutics for Acute Myocarditis

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Drug clinical trials:

Search ClinicalTrials for Acute Myocarditis

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

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Anatomical Context for Acute Myocarditis

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MalaCards organs/tissues related to Acute Myocarditis:

33
Heart, T cells, Liver, Cardiac myocytes, Kidney, Myeloid

Animal Models for Acute Myocarditis or affiliated genes

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Publications for Acute Myocarditis

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Articles related to Acute Myocarditis:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Diagnosis of acute myocarditis with dual source cardiac tomography. (25464460)
2015
2
Ultra-low dose comprehensive cardiac CT imaging in a patient with acute myocarditis. (25439792)
2014
3
Formation of a fibrin net on the polypropylene membrane oxygenator used for percutaneous cardiopulmonary support in a patient with acute myocarditis. (24875892)
2014
4
Acute myocarditis associated with coxsackievirus b4 mimicking influenza myocarditis: electron microscopy detection of causal virus of myocarditis. (24366591)
2013
5
Electrocardiographic findings and myocardial damage in acute myocarditis detected by cardiac magnetic resonance. (22388951)
2012
6
Altered left ventricular tissue velocities, deformation and twist in children and young adults with acute myocarditis and normal ejection fraction. (22101088)
2012
7
Rapidly fatal community-acquired pneumonia due to Klebsiella pneumoniae complicated with acute myocarditis and accelerated idioventricular rhythm. (22153763)
2012
8
A delayed diagnosis of acute myocarditis: diagnostic value of cardiovascular magnetic resonance imaging. (22892447)
2012
9
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
10
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
11
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. (19217318)
2010
12
Parvovirus B19 profiles in patients presenting with acute myocarditis and chronic dilated cardiomyopathy. (19043365)
2008
13
Late enhancement detected by cardiac magnetic resonance imaging in acute myocarditis mimicking acute myocardial infarction: location patterns and lack of correlation with systolic function. (18163015)
2007
14
Diagnostic value of ECG-gated multidetector computed tomography in the early phase of suspected acute myocarditis. A preliminary comparative study with cardiac MRI. (16953372)
2007
15
Muronomab-CD3 for pediatric acute myocarditis. (17165111)
2007
16
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
17
Immunity status against coxsackie viruses B in 25 patients with acute myocarditis. (18389726)
2006
18
Recovery of acute myocarditis with biventricular assist device in infant. (16274783)
2005
19
Short-term prognostic value of initial serum levels of interleukin-10 in patients with acute myocarditis. (15642541)
2005
20
Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. (15306225)
2004
21
Acute myocarditis associated with adenoviral infection in a patient with scleroderma. (14677036)
2003
22
Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (12031769)
2002
23
Acute myocarditis (predominately lymphocytic) causing sudden death without heart failure. (11704019)
2001
24
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
25
Acute myocarditis and left ventricular "hypertrophy". (11000592)
2000
26
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
27
Extracorporeal membrane oxygenation in treatment of cardiogenic shock caused by acute myocarditis. (9610063)
1998
28
Expression of cytokine mRNAs in murine hearts with acute myocarditis caused by coxsackievirus b3. (9370955)
1997
29
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
30
Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. (7635939)
1995
31
Acute myocarditis. Rapid diagnosis by PCR in children. (8026015)
1994
32
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
33
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
34
Detection of acute myocarditis using nuclear magnetic resonance imaging. (3400714)
1988
35
Increase in serum free fatty acids, phospholipids and reduction in total cholesterol in acute myocarditis produced by scorpion (Buthus tamulus) venom injection in dogs. (3570321)
1986
36
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
37
Liver glycogen depletion in acute myocarditis produced by scorpion venom (buthus tamulus). (6724623)
1984
38
Acute myocarditis associated with hepatitis B virus infection--a case report. (6629408)
1983
39
Left atrial myxoma. Clinical presentation suggesting acute myocarditis. (4479150)
1974
40
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
41
Coxsackie B5 virus responsible for acute myocarditis inucklings. (5439221)
1970
42
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
43
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
44
ACUTE MYOCARDITIS IN INFANCY AND CHILDHOOD. (14209575)
1964
45
ACUTE MYOCARDITIS IN THE ADULT. (14214812)
1964
46
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
47
ACUTE myocarditis. (13490888)
1957
48
Transient electrocardiographic changes simulating an acute myocarditis in serum sickness. (13065994)
1953
49
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946
50
A CASE OF DIPHTHERIAL ACUTE MYOCARDITIS STUDIED BY MEANS OF THE PORTABLE ELECTRO-CARDIOGRAPH. (20775498)
1930

Variations for Acute Myocarditis

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Expression for genes affiliated with Acute Myocarditis

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Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

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Pathways related to Acute Myocarditis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TRAIL signaling pathway38
9.5FAS, FASLG
29.5FASLG, FAS
3
Show member pathways
9.5FASLG, FAS
4
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.5FASLG, FAS
59.5FASLG, FAS
6
Show member pathways
9.5FASLG, FAS
7
Show member pathways
9.1FASLG, FAS, SDHA
8
Show member pathways
9.0CD70, FASLG, FAS
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0CD70, FASLG, FAS
10
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.9FAS, FASLG, ACE
118.7TXN, FAS, FASLG
128.7FASLG, FAS, TXN

Compounds for genes affiliated with Acute Myocarditis

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Compounds related to Acute Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1(glc)4459.9FAS, FASLG
2procainamide45 1310.9CD70, APOH
3teniposide45 1310.9FAS, FASLG
4concanamycin a45 6110.8FASLG, FAS
52-chlorodeoxyadenosine459.7FAS, FASLG
6p003459.7FASLG, APOH, TNC
7hydralazine45 51 1311.7CD70, ACE
8selenodiglutathione459.6FAS, TXN
9tgf beta1459.6TNC, FAS, FASLG
10atpo30 4510.5FASLG, FAS, APOH
11ivig459.5FASLG, FAS, APOH
12ubiquinone459.5SDHA, TXN
133-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5FASLG, FAS
14agarose459.5FASLG, FAS, APOH
15phosphatidylserine45 30 1311.5FASLG, FAS, APOH
16dutp459.4FASLG, FAS
17cystine459.4TXN, FASLG
18ionomycin459.4FAS, FASLG, CD70
19ly294002459.3FASLG, FAS, TNC
20rantes459.3FAS, FASLG, CD70
21aspirin45 51 30 2612.3ACE, FAS, APOH
22wortmannin459.3FASLG, FAS, TNC
23heparin45 30 26 1312.2FASLG, FAS, APOH, TNC
24paraffin459.2FASLG, FAS, TNC
25suberoylanilide hydroxamic acid459.1TXN, FAS, FASLG
26daunorubicin45 51 1311.1FASLG, FAS, TXN
27mitomycin c459.1TXN, FAS, FASLG
28phosphatidylinositol459.1TNC, APOH, FAS, FASLG
29resveratrol45 61 26 1312.1TXN, FAS, FASLG
30adriamycin459.1FASLG, FAS, TXN
31arsenite45 2610.1FASLG, FAS, TXN
32agar459.0FASLG, FAS, TXN
33etoposide45 51 61 1312.0TXN, FAS, FASLG
34n acetylcysteine459.0FASLG, FAS, TXN
35sulforaphane458.8TXN, FAS
36nitric oxide45 26 1310.8APOH, FAS, FASLG, ACE
37ascorbic acid45 269.8TNC, TXN, FAS, FASLG
38glutamate458.8TNC, TXN, APOH, FASLG
39actinomycin d458.8TNC, TXN, FAS, FASLG
40doxorubicin45 51 1310.7TXN, FAS, FASLG
41cycloheximide458.7FASLG, FAS, TXN, TNC
42h2o2458.7FASLG, FAS, TXN, TNC
43estrogen458.7FASLG, APOH, TXN, TNC
44dexamethasone45 51 30 1311.7TNC, TXN, FAS, FASLG
45lactate458.7FASLG, FAS, APOH, TXN
46oxygen45 269.6SDHA, TXN, APOH, FAS
47retinoic acid45 269.6TNC, TXN, FAS, FASLG
48cysteine458.6FASLG, FAS, TXN, TNC
49vegf458.4FASLG, FAS, APOH, TXN, TNC
50creatinine458.2ACE, FAS, APOH, TXN, TNC

GO Terms for genes affiliated with Acute Myocarditis

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Cellular components related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9ACE, FASLG, FAS
2extracellular spaceGO:00056158.0CD70, ACE, FASLG, APOH, TNC
3extracellular vesicular exosomeGO:00700627.2TXN, FAS, FASLG, ACE, CD70

Biological processes related to Acute Myocarditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00069259.7FASLG, FAS
2necroptotic signaling pathwayGO:00975279.6FAS, FASLG
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012399.6FASLG, FAS
4activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.5FASLG, FAS
5extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.4FAS, FASLG
6negative regulation of angiogenesisGO:00165259.3FASLG, APOH
7extrinsic apoptotic signaling pathwayGO:00971919.2CD70, FASLG, FAS
8cell-cell signalingGO:00072678.7TXN, FASLG, CD70
9signal transductionGO:00071658.2CD70, FASLG, FAS, TXN

Molecular functions related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.5CD70, FASLG
2protein bindingGO:00055156.4CD70, ACE, FASLG, FAS, APOH, TXN

Products for genes affiliated with Acute Myocarditis

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  • Antibodies
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Sources for Acute Myocarditis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet