MCID: ACT076
MIFTS: 42

Acute Myocarditis malady

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Acute Myocarditis

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Aliases & Descriptions for Acute Myocarditis:

Name: Acute Myocarditis 11 50 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:3951
ICD1030 I40, I40.9
ICD9CM32 422, 422.90
NCIt45 C35206

Summaries for Acute Myocarditis

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MalaCards based summary: Acute Myocarditis is related to lupus erythematosus and myocarditis. An important gene associated with Acute Myocarditis is CD40 (CD40 Molecule), and among its related pathways are Inflammatory Response Pathway and African trypanosomiasis. Affiliated tissues include heart, t cells and cardiac myocytes, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and immune system.

Related Diseases for Acute Myocarditis

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Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus29.4ACE, TNNI3
2myocarditis10.8
3giant cell myocarditis10.5
4myocardial infarction10.2
5cardiomyopathy10.2
6midline interhemispheric variant of holoprosencephaly10.2FAS, FASLG
7skeletal muscle cancer10.2FAS, FASLG
8parasitic ichthyosporea infectious disease10.2CD40, CD86
9leber congenital amaurosis10.1FAS, TNC
10macrogyria, pseudobulbar palsy and mental retardation10.1FAS, FASLG
11fiedler's myocarditis10.1
12cd3zeta deficiency10.1CD86, TNFSF8
13anauxetic dysplasia10.1FAS, FASLG
14acute myocardial infarction10.1
15mixed cell type cancer10.1FAS, FASLG
16breast adenomyoepithelioma10.1FAS, FASLG
17diabetes mellitus, insulin-dependent, 1210.1CD40, FAS, FASLG
18congestive heart failure10.0CD40, CD86, FAS
19dilated cardiomyopathy10.0
20pseudo-meigs syndrome10.0FAS, FASLG
21atrioventricular block10.0
22septic myocarditis10.0
23mesenteric lymphadenitis9.9ACE, CUX2
24influenza9.9
25aneurysm9.9
26skin conditions9.8ACE, FAS, FASLG
27systemic lupus erythematosus9.8
28cardiogenic shock9.8
29pericarditis9.8
30microscopic breast papilloma9.7ACE, CD40, CD86, TNNI3
31pneumonia9.7
32pheochromocytoma9.6
33malaria9.6
34cardiac tamponade9.6
35coronary artery vasospasm9.6
36parametritis9.6
37myopathy9.6
38diastolic heart failure9.6
39naxos disease9.5
40kawasaki disease9.5
41crohn's disease9.5
42dengue hemorrhagic fever9.5
43hepatitis9.5
44hepatitis b9.5
45ulcerative colitis9.5
46chikungunya9.5
47japanese spotted fever9.5
48third-degree atrioventricular block9.5
49colitis9.5
50atrial fibrillation9.5

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Ischemic Heart DiseaseHeart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Symptoms & Phenotypes for Acute Myocarditis

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GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.1ACE, CD40, FAS, FASLG, TNFSF8

MGI Mouse Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.9ACE, CD40, CD86, DMGDH, FAS, FASLG

Drugs & Therapeutics for Acute Myocarditis

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Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Ferrosoferric OxidePhase 2, Phase 365
2Parenteral Nutrition SolutionsPhase 2, Phase 3160
3Pharmaceutical SolutionsPhase 2, Phase 38192
4HematinicsPhase 2, Phase 31684
5Interleukin 1 Receptor Antagonist ProteinPhase 2, Phase 399
6Neurotransmitter AgentsPhase 2, Phase 318340
7Antirheumatic AgentsPhase 2, Phase 310956
8Adrenergic AgentsPhase 2, Phase 35352
9Adrenergic AntagonistsPhase 2, Phase 31573
10Adrenergic beta-AntagonistsPhase 2, Phase 31193
11
IronapprovedPhase 211657439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
12Antioxidants3050
13Protective Agents7443
14Tissue Inhibitor of Metalloproteinase-111
15Tissue Inhibitor of Metalloproteinases11
16TIMP1 protein, human11
17
protease inhibitors5471
Synonyms:
 
protease inhibitors
18Matrix Metalloproteinase Inhibitors19
19HIV Protease Inhibitors5470
20
Iodine5707553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
21cadexomer iodine537

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1DEtection of Cellular Inflammation With FERumoxytol in the HEARTCompletedNCT02319278Phase 2, Phase 3
2Anakinra Versus Placebo for the Treatment of Acute MyocarditISNot yet recruitingNCT03018834Phase 2, Phase 3
3IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioNUnknown statusNCT01995799Phase 2
4Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)Active, not recruitingNCT02293603Phase 1
5International Myocarditis RegistryUnknown statusNCT01307735
6Transient ECG Changes in Patients With Acute Biliary DiseaseUnknown statusNCT01706068
7Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) PatientsUnknown statusNCT01089036
8Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden DeathUnknown statusNCT01919983
9Cardiac Magnetic Resonance in Acute MyocarditisCompletedNCT02299856
10CMR in Patients With MyocarditisCompletedNCT01962584
11Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With MyocarditisCompletedNCT00693134
12Detection of Enterovirus RNA in Atheromatous LesionsCompletedNCT00674531
13German Centre for Cardiovascular Research Cardiomyopathy RegisterRecruitingNCT02187263
14Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary AtherosclerosisRecruitingNCT02655718
15Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRIRecruitingNCT02318498
16Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR ImagingRecruitingNCT02527330
17Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
18Evaluation of Spectral Cardiac CT for the Diagnosis of Acute MyocarditisNot yet recruitingNCT02905721
19French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRINot yet recruitingNCT02717143
20Cardiac and Laboratory Findings in Patients With Systemic Lupus ErythematosusNot yet recruitingNCT03179046
21Multicenter Cohort of STEMI PatientsNot yet recruitingNCT03070496

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

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Anatomical Context for Acute Myocarditis

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MalaCards organs/tissues related to Acute Myocarditis:

36
Heart, T cells, Cardiac myocytes, Liver, Kidney, Myeloid

Publications for Acute Myocarditis

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Articles related to Acute Myocarditis:

(show top 50)    (show all 459)
idTitleAuthorsYear
1
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. (28226202)
2017
2
Established and novel treatment options in acute myocarditis, with or without heart failure. (27858465)
2017
3
Incremental value of cardiac deformation analysis in acute myocarditis: a cardiovascular magnetic resonance imaging study. (27100527)
2016
4
Comprehensive Cardiac Magnetic Resonance for Short-Term Follow-Up in Acute Myocarditis. (27436306)
2016
5
Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis. (27913009)
2016
6
Acute Myocarditis With Very High Troponin but No Ventricular Dysfunction. (27356633)
2016
7
Cardiac MRI and acute myocarditis. (28062736)
2016
8
Usefulness of Late Iodine Enhancement on Spectral CT in Acute Myocarditis. (28017385)
2016
9
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii. (27085128)
2016
10
Arrhythmic risk prediction of acute myocarditis presenting with life-threatening ventricular tachyarrhythmias. (27038726)
2016
11
Left ventricular end-diastolic dimension as a predictive factor of outcomes in children with acute myocarditis. (27225897)
2016
12
Myocardial fibrosis detected with Gadolinium Delayed Enhancement in Cardiac Magnetic Resonance Imaging and Ventriculoarterial Coupling alterations in patients with Acute Myocarditis. (28081949)
2016
13
Persistent Atrial Standstill in Acute Myocarditis. (26897154)
2016
14
Clinicodemographic features and outcome of acute myocarditis in children admitted at tertiary care hospital. (27400295)
2016
15
Immunosuppressive Therapy and Interferon-1I^ in Acute Myocarditis. (27514623)
2016
16
Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus. (26922692)
2016
17
An autopsy case of cardiac tamponade caused by a ruptured ventricular aneurysm associated with acute myocarditis. (26832375)
2016
18
Reply: Nondilated Left Ventricle as an Adding Clue Helping Discrimination Between Acute Myocarditis From OtherA Cardiomyopathies. (27737751)
2016
19
Veno-veno-arterial ECMO support for acute myocarditis combined with ARDS: a case report. (26847501)
2016
20
The Prognostic Role of QTc Interval in Acute Myocarditis. (27122953)
2016
21
Acute respiratory distress syndrome and acute myocarditis developed in a previously healthy adult with influenza B. (26728359)
2016
22
Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis. (27472894)
2016
23
Prognostic value of the infarct- and non-infarct like patterns and cardiovascular magnetic resonance parameters on long-term outcome of patients after acute myocarditis. (27035605)
2016
24
Acute Myocarditis and ST-Segment Elevation. (27742420)
2016
25
A Case of Thiopurine-Induced Acute Myocarditis in a Patient with Ulcerative Colitis. (27766449)
2016
26
A unique association of arrhythmogenic right ventricular dysplasia and acute myocarditis, as assessed by cardiac MRI: a case report. (27871237)
2016
27
Usefulness of Subepicardial Hyperemia on Contrast-Enhanced First-Pass Magnetic Resonance Perfusion Imaging for Diagnosis of Acute Myocarditis. (27296557)
2016
28
Unusual Presentation of Dengue Fever: A child with acute myocarditis. (26909198)
2016
29
Role of 18F-Fluorodeoxyglucose/Positron Emission Tomography Imaging to Demonstrate Resolution of Acute Myocarditis. (27923584)
2016
30
Noninvasive imaging in acute myocarditis. (26731291)
2016
31
Relationship between T-wave inversion and transmural myocardial edema as evidenced by cardiac magnetic resonance in patients with clinically suspected acute myocarditis: clinical and prognostic implications. (27178316)
2016
32
Value of novel cardiac magnetic resonance indices for the diagnosis of acute myocarditis: Left ventricular mechanics and parametric mapping imaging. (27584565)
2016
33
Improving outcomes of acute myocarditis in children. (26588165)
2016
34
Nondilated Left Ventricle as an Adding Clue Helping Discrimination Between Acute Myocarditis From Other Cardiomyopathies. (27737750)
2016
35
Acute myocarditis with normal wall motion detected with 2D speckle tracking echocardiography. (27249814)
2016
36
Diagnostic implications of magnetic resonance feature tracking derived myocardial strain parameters in acute myocarditis. (26724669)
2016
37
Diagnosis of acute myocarditis with dual source cardiac tomography. (25464460)
2015
38
Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity. (26339812)
2015
39
Acute myocardial infarction or acute myocarditis? Discharge registry-based study of likelihood and associated features in hospitalised patients. (26009575)
2015
40
Acute Myocarditis and Myopathy as Presenting Manifestations of Human Immunodeficiency Virus Infection. (26394500)
2015
41
Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. (26476398)
2015
42
Acute Myocarditis in a Patient with Newly Diagnosed Granulomatosis with Polyangiitis. (26770838)
2015
43
Extracorporeal membrane oxygenation for the support of adults with acute myocarditis. (25738858)
2015
44
Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature. (26622337)
2015
45
Mapping tissue inhomogeneity in acute myocarditis: a novel analytical approach to quantitative myocardial edema imaging by T2-mapping. (26700020)
2015
46
Acute Myocarditis Diagnosed by Layer-Specific 2D Longitudinal Speckle Tracking Analysis. (26343232)
2015
47
Lights and shadows of cardiac magnetic resonance imaging in acute myocarditis. (26555392)
2015
48
Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis. (26002282)
2015
49
Myocardial oedema in acute myocarditis detected by echocardiographic 2D myocardial deformation analysis. (26588987)
2015
50
Cardiovascular magnetic resonance predictors of clinical outcome in patients with suspected acute myocarditis. (26318624)
2015

Variations for Acute Myocarditis

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Expression for genes affiliated with Acute Myocarditis

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Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

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Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CD40, CD86
29.7FAS, FASLG
3
Show member pathways
9.7FAS, FASLG
49.7FAS, FASLG
59.4ACE, CD40
69.4CD40, CD86, TNFSF8
7
Show member pathways
9.1CD40, CD86, FAS, FASLG
8
Show member pathways
8.9CD40, FAS, FASLG, TNFSF8
9
Show member pathways
8.9CD40, FAS, FASLG, TNFSF8
10
Show member pathways
8.3ACE, CD40, CD86, FAS, FASLG

GO Terms for genes affiliated with Acute Myocarditis

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Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.7CD40, CD86, FAS, FASLG
2external side of plasma membraneGO:00098978.3ACE, CD40, CD86, FAS, FASLG

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1B cell activationGO:004211310.6CD40, CD86
2response to interferon-gammaGO:003434110.5CD40, CD86
3positive regulation of endothelial cell apoptotic processGO:200035310.4CD40, FASLG
4activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.4FAS, FASLG
5extrinsic apoptotic signaling pathwayGO:009719110.4FAS, FASLG
6extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.4FAS, FASLG
7inflammatory cell apoptotic processGO:000692510.4FAS, FASLG
8necroptotic signaling pathwayGO:009752710.4FAS, FASLG
9negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.4FAS, FASLG
10regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.3FAS, FASLG
11regulation of cell proliferationGO:004212710.1CD40, FAS, TNC
12apoptotic signaling pathwayGO:009719010.1CD40, FAS, FASLG
13heart contractionGO:00600479.9ACE, TNNI3
14response to lipopolysaccharideGO:00324969.6CD40, CD86, FAS, FASLG
15immune responseGO:00069559.2CD40, CD86, FAS, FASLG, TNFSF8
16tumor necrosis factor-mediated signaling pathwayGO:00332098.9CD40, FAS, FASLG, TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:000487210.0CD40, CD86, FAS
2tumor necrosis factor receptor bindingGO:00051649.9FASLG, TNFSF8
3tumor necrosis factor-activated receptor activityGO:00050319.8CD40, FAS

Sources for Acute Myocarditis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet