Acute Myocarditis malady

MalaCards: Acute Myocarditis is related to myocarditis and systemic lupus erythematosus. An important gene associated with Acute Myocarditis is TNC (tenascin C), and among its related pathways are Lymphocyte Signaling and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds ivig and heparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and b cells, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Aliases & Descriptions:

acute myocarditis 6 8 32 43

Diseases related to acute myocarditis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 205)

id	Related Disease	Score	Top Affiliating Genes
1	myocarditis	27.4	SDHA, CD70, FGA, APOH, FABP3, FASLG
2	systemic lupus erythematosus	25.0	CD70, FGA, APOH, FASLG, FAS, PLAT
3	lupus erythematosus	25.0	CD70, FGA, APOH, FASLG, FAS, PLAT
4	myocardial infarction	24.0	FGA, APOH, FABP3, FAS, TXN, TNC
5	ischemia	23.3	SDHA, FGA, APOH, FABP3, FASLG, FAS
6	transient cerebral ischemia	13.2	FGA, APOH
7	intracranial thrombosis	13.2	FGA, APOH
8	antithrombin iii deficiency	13.1	FGA, APOH
9	alcoholic cardiomyopathy	13.0	APOH, ACE
10	bronchopulmonary dysplasia	12.9	TXN, TNC, ACE
11	fibromuscular dysplasia	12.9	APOH, ACE
12	congestive heart failure	12.9	FABP3, TXN, ACE
13	malignant hypertension	12.9	APOH, ACE
14	lumbar disc degeneration	12.8	FASLG, FAS
15	intestine carcinoma in situ	12.8	FASLG, FAS
16	nonalcoholic steatohepatitis	12.8	FAS, TXN, ABCB7
17	dysfibrinogenemia	12.7	FGA, PLAT
18	hepatitis c	12.7	FAS, TXN, ABCB7
19	acute t cell leukemia	12.7	FASLG, FAS
20	retinal artery occlusion	12.7	APOH, ACE
21	coronary thrombosis	12.7	FGA, PLAT
22	posterior uveitis	12.7	FASLG, FAS
23	congenital heart defect	12.6	FABP3, TXN, ABCB7, ACE
24	purpura fulminans	12.6	APOH, PLAT
25	hepatitis a	12.6	APOH, ABCB7, ACE
26	hypofibrinogenemia	12.6	FGA, PLAT
27	actinic keratosis	12.6	FASLG, FAS, TNC
28	central retinal vein occlusion	12.6	APOH, PLAT
29	hepatitis	12.6	FASLG, FAS, TXN
30	intermediate coronary syndrome	12.6	PLAT, ACE
31	thrombophlebitis	12.5	APOH, PLAT
32	venous tributary occlusion of retina	12.5	FGA, PLAT
33	lymphoproliferative syndrome	12.5	FASLG, FAS, TNFSF8
34	keratosis	12.5	FASLG, FAS, TNC
35	schistosomiasis	12.5	FGA, FAS, TXN, ABCB7
36	autoimmune thyroiditis	12.5	SDHA, FASLG, FAS
37	interstitial lung disease	12.5	CD70, TXN, TNC, TNFSF8, ACE
38	systemic scleroderma	12.5	FGA, APOH, TNC, ACE
39	spasticity	12.5	SDHA, FASLG, TXN, TNFSF8
40	non-hodgkin lymphoma	12.4	CD70, FGA, FAS, TNFSF8
41	coronary restenosis	12.4	PLAT, ACE
42	acute pancreatitis	12.4	APOH, TXN, ABCB7, ACE
43	portal vein thrombosis	12.4	APOH, PLAT, ABCB7
44	patent foramen ovale	12.4	FGA, APOH, PLAT
45	aortic valve stenosis	12.4	TNC, PLAT, ACE
46	adult t-cell leukemia	12.4	CD70, FASLG, FAS
47	thromboembolism	12.4	FGA, APOH, PLAT
48	venous thrombosis	12.4	FGA, APOH, PLAT
49	varicocele	12.3	FASLG, FAS, ACE
50	peripheral arterial occlusive disease	12.3	FGA, PLAT, ACE

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to acute myocarditis:

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MGI Mouse Phenotypes related to acute myocarditis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.5	FGA, FABP3, ABCB7
2	cardiovascular system phenotype	MP:0005385	6.6	FGA, PROM1, ACE, ABCB7, PLAT, FAS
3	homeostasis/metabolism phenotype	MP:0005376	6.0	ACE, ABCB7, PLAT, TNC, FAS, FASLG
4	mortality/aging	MP:0010768	5.7	PROM1, ACE, ABCB7, PLAT, TXN, FAS

Articles related to acute myocarditis:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	COMPARE-AMI trial: comparison of intracoronary inject ion of CD133+ bone marrow stem cells to placebo in patients after acute myocard ial infarction and left ventricular dysfunction: study rationale and design. (20560029)	Mansour S.... Noiseux N.	2010	PROM1
2	Long-term outcome after thrombectomy in acute myocard ial infarction. (20100234)	Adlbrecht C.... Lang I.M.	2010	FABP3
3	Should Angiotensin-converting enzyme inhibitors be continued over the long term in patients whose left ventricular ejection fraction normalizes after an episode of acute myocarditis? (17144995)	Anguita-SA!nchez M.... SuA!rez de Lezo J.	2006	ACE
4	Effect of the angiotensin II receptor blocker olmesartan on the development of murine acute myocarditis caused by coxsackievirus B3. (16336207)	Seko Y.	2006	FAS, FASLG
5	Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis. (15685595)	Morimoto S.... Hiroe M.	2005	TNC
6	Specific stimulation of peripheral blood mononuclear cells from patients with acute myocarditis by peptide-bound flavin adenine dinucleotide (FAD), a naturally occurring autologous hapten. (12699430)	Cicek G.... Brandsch R.	2003	SDHA
7	Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (12031769)	Seko Y.... Nagai R.	2002	CD70
8	Beta-blockers, angiotensin-converting enzyme inhibito rs, and calcium antagonists in treatment of elderly patients with acute myocard ial infarction. (10860176)	Aronow W.S.	2000	ACE
9	Differences in diagnostic criteria for acute myocard ial ischemia at Norwegian hospitals (9102977)	Fretland S.... KrA1ger O.	1997	ABCB7
10	Acute myocarditis and left ventricular aneurysm as pr esentations of systemic lupus erythematosus. (8549201)	Frustaci A.... Caldarulo M.	1996	APOH
11	Usefulness of fibrinogenolytic and procoagulant marke rs during thrombolytic therapy in predicting clinical outcomes in acute myocard ial infarction. TIMI-5 Investigators. Thrombolysis in Myocardial Infarction. (8806332)	Scharfstein J.S.... Loscalzo J.	1996	FGA
12	Importance of ST-segment depression as a determinant of ventricular premature complex frequency after thrombolysis for acute myocard ial infarction. Tissue Plasminogen Activator: Toronto (TPAT) Study Group. (7520209)	Dorian P.... Armstrong P.	1994	PLAT
13	The use of zofenopril and fosinopril in acute myocard ial infarction and carotid artery disease. (7818843)	Borghi C.... Ambrosioni E.	1994	ACE
14	Persistent generation of thrombin after acute myocard ial infarction. (1576116)	Szczeklik A.... Krzanowski M.	1992	FGA

Genes related to acute myocarditis according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	TNC	tenascin C	11.0	Publications
2	TXN	thioredoxin	11.0
3	CD70	CD70 molecule	11.0	Publications
4	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	11.0
5	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	11.0	Publications
6	SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	11.0	Publications
7	FGA	fibrinogen alpha chain	11.0	Publications
8	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
9	PROM1	prominin 1	11.0	Publications
10	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
11	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
12	PLAT	plasminogen activator, tissue	11.0	Publications
13	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
14	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications

Pathways related to acute myocarditis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Lymphocyte Signaling3	9.4	FASLG, TXN
2	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.1	FASLG, FAS
3	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	FAS, FASLG
4	Apoptosis and survival Apoptotic TNF-family pathways10	9.0	CD70, FASLG, FAS
5	Apoptosis and survival_Apoptotic TNF-family pathways41	9.0	CD70, FASLG, FAS
6	Cytokine-cytokine receptor interaction20	8.6	TNFSF8, FAS, FASLG, CD70
7	Chagas disease (American trypanosomiasis)20	8.6	FASLG, FAS, ACE

Compounds related to acute myocarditis according to GeneDecks:

(show top 50)    (show all 57)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.3	FASLG
2	heparin32 9 18 9	13.0	FGA, TNC, ABCB7
3	aspartate32	10.0	FASLG, ABCB7
4	an 6932	9.9	ACE, FGA
5	11-dehydrothromboxane b232	9.9	FGA, APOH
6	desirudin32	9.9	PLAT, FGA
7	fibrinopeptide a32	9.9	PLAT, FGA
8	batroxobin32	9.8	PLAT, FGA
9	ancrod32	9.8	PLAT, FGA
10	selenodiglutathione32	9.8	TXN, FAS
11	bivalirudin32 9 9	11.8	FGA, PLAT
12	delapril32	9.7	ACE, PLAT
13	argatroban32 9 9	11.7	FGA, PLAT
14	manidipine32	9.7	ACE, PLAT
15	ppack32	9.7	PLAT, FGA
16	palmitate32	9.7	FABP3, PLAT
17	procainamide32 9 9	11.7	CD70, APOH
18	omapatrilat32	9.6	PLAT, ACE
19	progesterone32 42 9 18 9	13.5	ABCB7, PLAT, TNC
20	quinapril32 9 9	11.5	ACE, PLAT
21	(glc)432	9.5	FASLG, FAS
22	enalaprilat32	9.5	ACE, PLAT
23	ticlopidine32 9 9	11.5	PLAT, APOH, FGA
24	ptca32	9.5	FGA, APOH, PLAT
25	thromboxane32 18	10.4	PLAT, APOH, FGA
26	thromboxane a232 18	10.3	FGA, APOH, PLAT
27	glutamate32	9.3	PLAT, TNC, TXN, APOH
28	p00232	9.3	PLAT, TNC, FABP3, APOH
29	suberoylanilide hydroxamic acid32	9.3	FASLG, FAS, TXN
30	kininogen32	9.2	APOH, PLAT, ACE
31	pge132	9.2	PLAT, TXN, APOH, FGA
32	daunorubicin32 9 9	11.2	FASLG, FAS, TXN
33	mitomycin c32	9.1	TXN, FAS, FASLG
34	atpo32	9.1	APOH, FASLG, FAS
35	ascorbic acid32 18	10.1	FASLG, FAS, TXN, TNC
36	warfarin32 34 9 18 9	13.0	FGA, APOH, PLAT, ACE
37	prostacyclin32	8.9	ACE, PLAT, APOH, FGA
38	fibrinogen32	8.9	ABCB7, PLAT, TNC, APOH, FGA
39	p00332	8.8	PLAT, TNC, FASLG, FABP3, APOH
40	resveratrol32 9 18 9	11.6	TXN, FAS, FASLG
41	sodium nitroprusside32	8.6	PLAT, FAS, FASLG
42	actinomycin d32	8.4	FASLG, FAS, TXN, TNC, PLAT
43	cycloheximide32	8.4	PLAT, TNC, TXN, FAS, FASLG
44	paraffin32	8.3	FASLG, FAS, TNC, PLAT
45	lipid32	8.2	PROM1, ACE, ABCB7, TNC, FABP3, APOH
46	vegf32	8.2	TNC, TXN, FAS, FASLG, APOH
47	aspirin32 34 18	10.1	ACE, PLAT, FAS, APOH, FGA
48	lactate32	7.9	ABCB7, TXN, FAS, FASLG, FABP3, APOH
49	cholesterol32 9 18 9	10.8	ACE, ABCB7, PLAT, FASLG, FABP3, APOH
50	creatinine32	7.0	FGA, ACE, ABCB7, PLAT, TNC, TXN

Cellular components related to acute myocarditis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.3	FGA, FASLG, FAS, ACE
2	extracellular space	GO:005615	6.5	CD70, PROM1, ACE, PLAT, TNFSF8, TNC

Biological processes related to acute myocarditis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasminogen activation	GO:031639	9.4	APOH, PLAT
2	inflammatory cell apoptotic process	GO:006925	9.2	FASLG, FAS
3	induction of apoptosis via death domain receptors	GO:008625	9.1	FASLG, FAS
4	cell-cell signaling	GO:007267	9.1	TNFSF8, TXN, FASLG, CD70
5	response to growth factor stimulus	GO:070848	8.8	FASLG, FAS
6	induction of apoptosis	GO:006917	8.6	TNFSF8, FAS, FASLG, CD70
7	signal transduction	GO:007165	7.9	CD70, TNFSF8, TNC, TXN, FAS, FASLG

Molecular functions related to acute myocarditis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor receptor binding	GO:005164	9.1	TNFSF8, FASLG, CD70
2	receptor binding	GO:005102	8.7	CD70, FGA, FASLG, TNC, TNFSF8
3	protein binding	GO:005515	5.6	ACE, PLAT, TXN, FAS, FASLG, FABP3