MCID: ACT076
MIFTS: 36

Acute Myocarditis malady

Cardiovascular diseases, Muscle diseases, Rare diseases categories

Aliases & Classifications for Acute Myocarditis

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 59SNOMED-CT, 29ICD9CM, 42NCIt, 27ICD10
See all sources

Aliases & Descriptions for Acute Myocarditis:

Name: Acute Myocarditis 10 47 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:3951
ICD9CM29 422.90, 422
NCIt42 C35206
ICD1027 I40

Summaries for Acute Myocarditis

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MalaCards based summary: Acute Myocarditis is related to myocardial infarction and systemic lupus erythematosus. An important gene associated with Acute Myocarditis is TNC (Tenascin C), and among its related pathways are Inflammatory Response Pathway and African trypanosomiasis. Affiliated tissues include heart, t cells and cardiac myocytes.

Related Diseases for Acute Myocarditis

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Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction30.7ACE, TNC, TNNI3, TNNT2
2systemic lupus erythematosus30.4CD40, CD86, FAS, FASLG
3acute orbital inflammation28.0ACE, CD40, CD86, DMGDH, FAS, FASLG
4myocarditis11.3
5cardiomyopathy10.7
6acute myocardial infarction10.6
7dilated cardiomyopathy10.6
8atrioventricular block10.5
9influenza10.4
10lupus erythematosus10.4
11aneurysm10.4
12cardiogenic shock10.4
13pericarditis10.3
14eosinophilia10.3
15pneumonia10.3
16heavy chain deposition disease10.2FAS, FASLG
17fungal gastritis10.2FAS, FASLG
18lymphomatous thyroiditis10.2FAS, FASLG
19cartilage-hair hypoplasia10.2FAS, FASLG
20keratoconus10.2FAS, TNC
21pheochromocytoma10.2
22malaria10.2
23coronary artery vasospasm10.2
24hypertrophic cardiomyopathy10.2
25diastolic heart failure10.2
26myopathy10.2
27c1 inhibitor deficiency10.2CD40, CD86
28developmental and speech delay due to sox5 deficiency10.2FAS, FASLG
29discrete subaortic stenosis10.1CD40, CD86
30cancer-associated retinopathy10.1TNNI3, TNNT2
31transient retinal arterial occlusion10.1TNNI3, TNNT2
32coronary heart disease 210.0
33noonan syndrome 110.0
34naxos disease10.0
35kawasaki disease10.0
36crohn's disease10.0
37dengue hemorrhagic fever10.0
38hepatitis10.0
39hepatitis b10.0
40parametritis10.0
41chagas disease10.0
42acute pancreatitis10.0
43mumps10.0
44erysipelas10.0
45cardiac tamponade10.0
46parotitis10.0
47neuronitis10.0
48appendicitis10.0
49fiedler's myocarditis10.0
50bullous pemphigoid10.0

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Symptoms for Acute Myocarditis

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Drugs & Therapeutics for Acute Myocarditis

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Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Ferrosoferric OxidePhase 2, Phase 357
2
IronapprovedPhase 29577439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
3Tissue Inhibitor of Metalloproteinases8
4TIMP1 protein, human8
5Tissue Inhibitor of Metalloproteinase-18

Interventional clinical trials:

(show all 15)
idNameStatusNCT IDPhase
1DEtection of Cellular Inflammation With FERumoxytol in the HEARTRecruitingNCT02319278Phase 2, Phase 3
2IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioNRecruitingNCT01995799Phase 2
3Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)Active, not recruitingNCT02293603Phase 1
4Cardiac Magnetic Resonance in Acute MyocarditisCompletedNCT02299856
5CMR in Patients With MyocarditisCompletedNCT01962584
6Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With MyocarditisCompletedNCT00693134
7Detection of Enterovirus RNA in Atheromatous LesionsCompletedNCT00674531
8German Centre for Cardiovascular Research Cardiomyopathy RegisterRecruitingNCT02187263
9Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary AtherosclerosisRecruitingNCT02655718
10Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) PatientsRecruitingNCT01089036
11Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR ImagingRecruitingNCT02527330
12Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRIRecruitingNCT02318498
13Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden DeathRecruitingNCT01919983
14International Myocarditis RegistryEnrolling by invitationNCT01307735
15Transient ECG Changes in Patients With Acute Biliary DiseaseNot yet recruitingNCT01706068

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

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Anatomical Context for Acute Myocarditis

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MalaCards organs/tissues related to Acute Myocarditis:

33
Heart, T cells, Cardiac myocytes, Liver, Kidney, Myeloid

Animal Models for Acute Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Acute Myocarditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Acute Myocarditis

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Articles related to Acute Myocarditis:

(show top 50)    (show all 416)
idTitleAuthorsYear
1
Atrial Fibrillation Due to Acute Myocarditis During Dengue Haemorrhagic Fever. (26500943)
2015
2
Diagnosis of acute myocarditis with dual source cardiac tomography. (25464460)
2015
3
Ultra-low dose comprehensive cardiac CT imaging in a patient with acute myocarditis. (25439792)
2014
4
Formation of a fibrin net on the polypropylene membrane oxygenator used for percutaneous cardiopulmonary support in a patient with acute myocarditis. (24875892)
2014
5
Acute myocarditis associated with coxsackievirus b4 mimicking influenza myocarditis: electron microscopy detection of causal virus of myocarditis. (24366591)
2013
6
Electrocardiographic findings and myocardial damage in acute myocarditis detected by cardiac magnetic resonance. (22388951)
2012
7
Altered left ventricular tissue velocities, deformation and twist in children and young adults with acute myocarditis and normal ejection fraction. (22101088)
2012
8
Rapidly fatal community-acquired pneumonia due to Klebsiella pneumoniae complicated with acute myocarditis and accelerated idioventricular rhythm. (22153763)
2012
9
A delayed diagnosis of acute myocarditis: diagnostic value of cardiovascular magnetic resonance imaging. (22892447)
2012
10
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
11
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
12
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. (19217318)
2010
13
Parvovirus B19 profiles in patients presenting with acute myocarditis and chronic dilated cardiomyopathy. (19043365)
2008
14
Late enhancement detected by cardiac magnetic resonance imaging in acute myocarditis mimicking acute myocardial infarction: location patterns and lack of correlation with systolic function. (18163015)
2007
15
Diagnostic value of ECG-gated multidetector computed tomography in the early phase of suspected acute myocarditis. A preliminary comparative study with cardiac MRI. (16953372)
2007
16
Muronomab-CD3 for pediatric acute myocarditis. (17165111)
2007
17
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
18
Immunity status against coxsackie viruses B in 25 patients with acute myocarditis. (18389726)
2006
19
Recovery of acute myocarditis with biventricular assist device in infant. (16274783)
2005
20
Short-term prognostic value of initial serum levels of interleukin-10 in patients with acute myocarditis. (15642541)
2005
21
Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. (15306225)
2004
22
Acute myocarditis associated with adenoviral infection in a patient with scleroderma. (14677036)
2003
23
Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (12031769)
2002
24
Acute myocarditis (predominately lymphocytic) causing sudden death without heart failure. (11704019)
2001
25
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
26
Acute myocarditis and left ventricular "hypertrophy". (11000592)
2000
27
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
28
Extracorporeal membrane oxygenation in treatment of cardiogenic shock caused by acute myocarditis. (9610063)
1998
29
Expression of cytokine mRNAs in murine hearts with acute myocarditis caused by coxsackievirus b3. (9370955)
1997
30
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
31
Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. (7635939)
1995
32
Acute myocarditis. Rapid diagnosis by PCR in children. (8026015)
1994
33
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
34
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
35
Detection of acute myocarditis using nuclear magnetic resonance imaging. (3400714)
1988
36
Increase in serum free fatty acids, phospholipids and reduction in total cholesterol in acute myocarditis produced by scorpion (Buthus tamulus) venom injection in dogs. (3570321)
1986
37
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
38
Liver glycogen depletion in acute myocarditis produced by scorpion venom (buthus tamulus). (6724623)
1984
39
Acute myocarditis associated with hepatitis B virus infection--a case report. (6629408)
1983
40
Left atrial myxoma. Clinical presentation suggesting acute myocarditis. (4479150)
1974
41
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
42
Coxsackie B5 virus responsible for acute myocarditis inucklings. (5439221)
1970
43
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
44
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
45
ACUTE MYOCARDITIS IN INFANCY AND CHILDHOOD. (14209575)
1964
46
ACUTE MYOCARDITIS IN THE ADULT. (14214812)
1964
47
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
48
ACUTE myocarditis. (13490888)
1957
49
Transient electrocardiographic changes simulating an acute myocarditis in serum sickness. (13065994)
1953
50
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946

Variations for Acute Myocarditis

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Expression for genes affiliated with Acute Myocarditis

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Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

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Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CD40, CD86
29.8FAS, FASLG
3
Show member pathways
9.8FAS, FASLG
49.7TNC, TNNI3
59.7TNC, TNNI3
69.6ACE, CD40
7
Show member pathways
9.1CD40, CD86, FAS, FASLG
8
TNF Signaling (sino)
Show member pathways
8.8CD40, CD86, FAS, FASLG
9
Show member pathways
8.8CD40, FAS, FASLG, TNFSF8
10
Show member pathways
8.6ACE, CD40, CD86, FAS, FASLG

GO Terms for genes affiliated with Acute Myocarditis

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Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1troponin complexGO:000586110.1TNNI3, TNNT2
2sarcomereGO:003001710.0TNNI3, TNNT2
3myofibrilGO:003001610.0TNNI3, TNNT2
4external side of plasma membraneGO:00098978.9ACE, CD40, CD86, FAS, FASLG
5extracellular spaceGO:00056158.4ACE, CD40, FASLG, TNC, TNFSF8

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.4FAS, FASLG
2necroptotic signaling pathwayGO:009752710.4FAS, FASLG
3activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.3FAS, FASLG
4regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.3FAS, FASLG
5regulation of necrotic cell deathGO:001093910.3FAS, FASLG
6necroptotic processGO:007026610.3FAS, FASLG
7programmed necrotic cell deathGO:009730010.3FAS, FASLG
8extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.3FAS, FASLG
9positive regulation of endothelial cell apoptotic processGO:200035310.2CD40, FASLG
10B cell activationGO:004211310.2CD40, CD86
11negative regulation of ATPase activityGO:003278010.0TNNI3, TNNT2
12regulation of muscle contractionGO:000693710.0TNNI3, TNNT2
13ventricular cardiac muscle tissue morphogenesisGO:00550109.9TNNI3, TNNT2
14heart contractionGO:00600479.9ACE, TNNI3
15muscle filament slidingGO:00300499.5TNNI3, TNNT2
16apoptotic signaling pathwayGO:00971909.4CD40, FAS, FASLG
17response to lipopolysaccharideGO:00324969.2CD40, CD86, FAS, FASLG
18immune responseGO:00069558.5CD86, FAS, FASLG, TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:000503110.1CD40, FAS
2troponin C bindingGO:00301729.9TNNI3, TNNT2
3tumor necrosis factor receptor bindingGO:00051649.8FASLG, TNFSF8
4receptor activityGO:00048729.4CD40, CD86, FAS

Sources for Acute Myocarditis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet