MCID: ACT076
MIFTS: 46

Acute Myocarditis malady

Cardiovascular diseases, Rare diseases categories
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Summaries for Acute Myocarditis

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33MalaCards
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MalaCards: Acute Myocarditis is related to myocarditis and acute myocardial infarction. An important gene associated with Acute Myocarditis is TNC (tenascin C), and among its related pathways are FAS (CD95) signaling pathway and African trypanosomiasis. The compounds (glc)4 and procainamide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver.

Aliases & Classifications for Acute Myocarditis

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8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

acute myocarditis 8 45 62


External Ids:

Disease Ontology8 DOID:3951
NCIt40 C35206
ICD9CM27 422, 422.90
ICD1025 I40

Related Diseases for Acute Myocarditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis32.1TXN
2acute myocardial infarction30.8TNC, TXN, ACE
3lupus erythematosus30.6CD70, APOH
4systemic lupus erythematosus30.4FAS, FASLG, CD70, APOH
5hepatitis29.9FASLG, FAS, TXN
6myocardial infarction10.7
7atrioventricular block10.5
8dilated cardiomyopathy10.5
9influenza10.3
10aneurysm10.3
11cardiogenic shock10.3
12pericarditis10.3
13eosinophilia10.2
14pneumonia10.2
15coronary artery vasospasm10.1
16hypertrophic cardiomyopathy10.1
17diastolic heart failure10.1
18acute orbital inflammation10.1
19malaria10.1
20pheochromocytoma10.1
21klebsiella10.1
22uveitis10.1ACE
23systemic scleroderma10.1ACE
24retinal artery occlusion10.1APOH
25benign mesothelioma10.1TXN, TNC
26hyperhomocysteinemia10.0APOH, TXN
27cerebrovascular disease10.0APOH, ACE
28congestive heart failure10.0TXN, ACE
29idiopathic pulmonary fibrosis10.0FASLG, TNC
30keloids10.0FAS, TNC
31nephritis10.0APOH, ACE
32vascular disease10.0ACE, TNC, APOH
33toxic epidermal necrolysis10.0FAS, FASLG
34vogt-koyanagi-harada disease10.0FASLG, FAS
35silicosis10.0FAS, FASLG
36lymphomatoid papulosis10.0FASLG, FAS
37stevens-johnson syndrome10.0FASLG, FAS
38rubella10.0
39crohn's disease10.0
40cardiac tamponade10.0
41acute pancreatitis10.0
42third-degree atrioventricular block10.0
43fiedler's myocarditis10.0
44neuronitis10.0
45appendicitis10.0
46bullous pemphigoid10.0
47parotitis10.0
48hepatitis b10.0
49infectious mononucleosis10.0
50churg-strauss syndrome10.0

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Symptoms for Acute Myocarditis

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Drugs & Therapeutics for Acute Myocarditis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Myocarditis

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

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Anatomical Context for Acute Myocarditis

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33MalaCards
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MalaCards organs/tissues related to Acute Myocarditis:

33
Heart, T cells, Liver, Cardiac myocytes, Kidney

Animal Models for Acute Myocarditis or affiliated genes

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Publications for Acute Myocarditis

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Sources:
52PubMed
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Articles related to Acute Myocarditis:

(show top 50)    (show all 373)
idTitleAuthorsYear
1
Acute myocarditis associated with coxsackievirus b4 mimicking influenza myocarditis: electron microscopy detection of causal virus of myocarditis. (24366591)
2013
2
Electrocardiographic findings and myocardial damage in acute myocarditis detected by cardiac magnetic resonance. (22388951)
2012
3
Altered left ventricular tissue velocities, deformation and twist in children and young adults with acute myocarditis and normal ejection fraction. (22101088)
2012
4
Rapidly fatal community-acquired pneumonia due to Klebsiella pneumoniae complicated with acute myocarditis and accelerated idioventricular rhythm. (22153763)
2012
5
A delayed diagnosis of acute myocarditis: diagnostic value of cardiovascular magnetic resonance imaging. (22892447)
2012
6
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
7
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
8
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. (19217318)
2010
9
Parvovirus B19 profiles in patients presenting with acute myocarditis and chronic dilated cardiomyopathy. (19043365)
2008
10
Late enhancement detected by cardiac magnetic resonance imaging in acute myocarditis mimicking acute myocardial infarction: location patterns and lack of correlation with systolic function. (18163015)
2007
11
Diagnostic value of ECG-gated multidetector computed tomography in the early phase of suspected acute myocarditis. A preliminary comparative study with cardiac MRI. (16953372)
2007
12
Muronomab-CD3 for pediatric acute myocarditis. (17165111)
2007
13
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
14
Immunity status against coxsackie viruses B in 25 patients with acute myocarditis. (18389726)
2006
15
Recovery of acute myocarditis with biventricular assist device in infant. (16274783)
2005
16
Short-term prognostic value of initial serum levels of interleukin-10 in patients with acute myocarditis. (15642541)
2005
17
Transatrial resection of a left ventricular thrombus after acute myocarditis. (16160906)
2005
18
Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. (15306225)
2004
19
Acute myocarditis associated with adenoviral infection in a patient with scleroderma. (14677036)
2003
20
Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (12031769)
2002
21
Acute myocarditis (predominately lymphocytic) causing sudden death without heart failure. (11704019)
2001
22
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
23
Acute myocarditis and left ventricular "hypertrophy". (11000592)
2000
24
Acute myocarditis precipitated by Salmonella Montevideo infection: a case report. (10740371)
2000
25
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
26
Extracorporeal membrane oxygenation in treatment of cardiogenic shock caused by acute myocarditis. (9610063)
1998
27
Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies. (9721703)
1998
28
Expression of cytokine mRNAs in murine hearts with acute myocarditis caused by coxsackievirus b3. (9370955)
1997
29
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
30
Acute myocarditis. Rapid diagnosis by PCR in children. (8026015)
1994
31
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
32
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
33
Detection of acute myocarditis using nuclear magnetic resonance imaging. (3400714)
1988
34
Increase in serum free fatty acids, phospholipids and reduction in total cholesterol in acute myocarditis produced by scorpion (Buthus tamulus) venom injection in dogs. (3570321)
1986
35
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
36
Liver glycogen depletion in acute myocarditis produced by scorpion venom (buthus tamulus). (6724623)
1984
37
Acute myocarditis associated with hepatitis B virus infection--a case report. (6629408)
1983
38
Left atrial myxoma. Clinical presentation suggesting acute myocarditis. (4479150)
1974
39
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
40
Coxsackie B5 virus responsible for acute myocarditis inucklings. (5439221)
1970
41
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
42
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
43
ACUTE MYOCARDITIS IN INFANCY AND CHILDHOOD. (14209575)
1964
44
ACUTE MYOCARDITIS IN THE ADULT. (14214812)
1964
45
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
46
ACUTE myocarditis. (13490888)
1957
47
Electrocardiogram of the month: acute myocarditis. (13320513)
1956
48
Transient electrocardiographic changes simulating an acute myocarditis in serum sickness. (13065994)
1953
49
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946
50
A CASE OF DIPHTHERIAL ACUTE MYOCARDITIS STUDIED BY MEANS OF THE PORTABLE ELECTRO-CARDIOGRAPH. (20775498)
1930

Variations for Acute Myocarditis

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Expression for genes affiliated with Acute Myocarditis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 60Thomson Reuters, 54R&D Systems, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Acute Myocarditis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TRAIL signaling pathway38
9.5FAS, FASLG
29.5FASLG, FAS
3
Show member pathways
9.5FASLG, FAS
4
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.5FASLG, FAS
59.5FASLG, FAS
6
Show member pathways
9.5FASLG, FAS
7
Show member pathways
9.1FASLG, FAS, SDHA
8
Show member pathways
9.0CD70, FASLG, FAS
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0CD70, FASLG, FAS
10
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.9FAS, FASLG, ACE
118.7TXN, FAS, FASLG
128.7FASLG, FAS, TXN

Compounds for genes affiliated with Acute Myocarditis

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Acute Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1(glc)4459.9FASLG, FAS
2procainamide45 1110.9APOH, CD70
3teniposide45 1110.9FASLG, FAS
4concanamycin a45 6110.8FAS, FASLG
5p003459.7TNC, APOH, FASLG
6hydralazine45 51 1111.7ACE, CD70
72-chlorodeoxyadenosine459.7FASLG, FAS
8selenodiglutathione459.6TXN, FAS
9tgf beta1459.6FAS, TNC, FASLG
10atpo29 4510.5FASLG, APOH, FAS
11ivig459.5FAS, APOH, FASLG
12ubiquinone459.5TXN, SDHA
13dutp459.5FAS, FASLG
14agarose459.5APOH, FASLG, FAS
15phosphatidylserine45 29 1111.5FAS, FASLG, APOH
16cystine459.4TXN, FASLG
173-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.4FAS, FASLG
18ionomycin459.4CD70, FAS, FASLG
19ly294002459.3FASLG, FAS, TNC
20rantes459.3FASLG, FAS, CD70
21aspirin45 51 29 2412.3ACE, APOH, FAS
22wortmannin459.3TNC, FAS, FASLG
23heparin45 29 24 1112.2FASLG, APOH, FAS, TNC
24paraffin459.2TNC, FAS, FASLG
25suberoylanilide hydroxamic acid459.1TXN, FAS, FASLG
26daunorubicin45 51 1111.1FAS, TXN, FASLG
27mitomycin c459.1FAS, FASLG, TXN
28phosphatidylinositol459.1TNC, FAS, FASLG, APOH
29resveratrol45 61 24 1112.1FASLG, TXN, FAS
30adriamycin459.1FASLG, FAS, TXN
31arsenite45 2410.1FASLG, TXN, FAS
32agar459.0FASLG, FAS, TXN
33etoposide45 51 61 1112.0FAS, TXN, FASLG
34n acetylcysteine459.0FAS, TXN, FASLG
35sulforaphane458.8TXN, FAS
36nitric oxide45 24 1110.8ACE, FAS, APOH, FASLG
37ascorbic acid45 249.8FAS, FASLG, TXN, TNC
38glutamate458.8TNC, FASLG, TXN, APOH
39actinomycin d458.8FASLG, TNC, TXN, FAS
40doxorubicin45 51 1110.7TXN, FAS, FASLG
41cycloheximide458.7FASLG, TXN, TNC, FAS
42h2o2458.7FASLG, TNC, TXN, FAS
43estrogen458.7APOH, TXN, FASLG, TNC
44dexamethasone45 51 29 1111.7TNC, TXN, FAS, FASLG
45lactate458.7APOH, TXN, FASLG, FAS
46oxygen45 249.6FAS, APOH, SDHA, TXN
47retinoic acid45 249.6FAS, FASLG, TNC, TXN
48cysteine458.6TNC, FASLG, TXN, FAS
49vegf458.4FAS, FASLG, TNC, TXN, APOH
50creatinine458.2TXN, APOH, TNC, ACE, FAS

GO Terms for genes affiliated with Acute Myocarditis

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16Gene Ontology
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Cellular components related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ACE, FASLG, FAS
2extracellular spaceGO:0056158.0CD70, ACE, FASLG, APOH, TNC
3extracellular vesicular exosomeGO:0700627.2TXN, FAS, FASLG, ACE, CD70

Biological processes related to Acute Myocarditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.7FASLG, FAS
2necroptotic signaling pathwayGO:0975279.6FAS, FASLG
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.6FASLG, FAS
4activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.5FASLG, FAS
5extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.4FAS, FASLG
6negative regulation of angiogenesisGO:0165259.3FASLG, APOH
7extrinsic apoptotic signaling pathwayGO:0971919.2CD70, FASLG, FAS
8cell-cell signalingGO:0072678.7TXN, FASLG, CD70
9signal transductionGO:0071658.2CD70, FASLG, FAS, TXN

Molecular functions related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5CD70, FASLG
2protein bindingGO:0055156.4CD70, ACE, FASLG, FAS, APOH, TXN

Products for genes affiliated with Acute Myocarditis

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  • Antibodies
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Sources for Acute Myocarditis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet