MCID: ACT076
MIFTS: 44

Acute Myocarditis

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD10 33 I40 I40.9
ICD9CM 35 422 422.90
NCIt 47 C35206
UMLS 69 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to myocarditis and giant cell myocarditis. An important gene associated with Acute Myocarditis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. The drugs Ferrosoferric Oxide and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and cardiac myocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and endocrine/exocrine gland

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
id Related Disease Score Top Affiliating Genes
1 myocarditis 10.8
2 giant cell myocarditis 10.5
3 trichosporonosis 10.4 CD40 CD86
4 artemis deficiency 10.2 CD86 TNFSF8
5 spinal polio 10.2 CD40 CD86
6 myocardial infarction 10.2
7 cardiomyopathy 10.2
8 juvenile sialidosis type 2 10.2 FAS FASLG
9 keratopathy 10.1 FAS TNC
10 gastrointestinal tuberculosis 10.1 FAS FASLG
11 fiedler's myocarditis 10.1
12 macrocephaly, mental retardation, short stature, spastic paraplegia and cns malformations 10.1 FAS FASLG
13 acute myocardial infarction 10.1
14 metaphyseal dysplasia without hypotrichosis 10.1 FAS FASLG
15 dilated cardiomyopathy 10.0
16 atrioventricular block 10.0
17 septic myocarditis 10.0
18 angiodysplasia of intestine 10.0 STAT1 TLR3
19 influenza 9.9
20 spondyloarthropathy 1 9.9 FAS FASLG TLR3
21 aneurysm 9.9
22 diabetes mellitus, insulin-dependent, 12 9.8 CD40 FAS FASLG
23 systemic lupus erythematosus 9.8
24 lupus erythematosus 9.8
25 cardiogenic shock 9.8
26 pericarditis 9.8
27 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 9.8 FAS FASLG
28 pneumonia 9.7
29 congenital symblepharon 9.7 CD40 CD70 CD86 FAS
30 lung superior sulcus carcinoma 9.6 CD40 CD86 TNNI3
31 pheochromocytoma 9.6
32 malaria 9.6
33 cardiac tamponade 9.6
34 coronary artery vasospasm 9.6
35 parametritis 9.6
36 myopathy 9.6
37 diastolic heart failure 9.6
38 hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation 9.6 SDHA TNNI3
39 smoking as a quantitative trait locus 1 9.6 CD40 FAS TNFSF8
40 breast adenomyoepithelioma 9.6 FAS FASLG STAT1
41 cervical benign neoplasm 9.6 FAS FASLG
42 naxos disease 9.5
43 kawasaki disease 9.5
44 crohn's disease 9.5
45 dengue hemorrhagic fever 9.5
46 hepatitis 9.5
47 hepatitis b 9.5
48 ulcerative colitis 9.5
49 chikungunya 9.5
50 japanese spotted fever 9.5

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD70 FAS STAT1 TNFSF8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CD40 CD70 FAS FASLG STAT1 TNFSF8
3 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 9.26 CD70 CD86 SDHA TNNI3

MGI Mouse Phenotypes related to Acute Myocarditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 CD40 CD86 FAS FASLG STAT1 TLR3
2 hematopoietic system MP:0005397 9.7 CD40 CD70 CD86 FAS FASLG STAT1
3 homeostasis/metabolism MP:0005376 9.56 FAS FASLG SDHA STAT1 TLR3 TNC
4 immune system MP:0005387 9.23 CD40 CD70 CD86 FAS FASLG STAT1

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ferrosoferric Oxide Phase 2, Phase 3
2 Hematinics Phase 2, Phase 3
3 Parenteral Nutrition Solutions Phase 2, Phase 3
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Adrenergic Agents Phase 2, Phase 3
6 Adrenergic Antagonists Phase 2, Phase 3
7 Adrenergic beta-Antagonists Phase 2, Phase 3
8 Neurotransmitter Agents Phase 2, Phase 3
9 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
10 Antirheumatic Agents Phase 2, Phase 3
11
Iodine Investigational 7553-56-2 807
12
protease inhibitors
13 TIMP1 protein, human
14 Tissue Inhibitor of Metalloproteinase-1
15 Tissue Inhibitor of Metalloproteinases
16 HIV Protease Inhibitors
17 Matrix Metalloproteinase Inhibitors
18 cadexomer iodine

Interventional clinical trials:

(show all 12)

id Name Status NCT ID Phase Drugs
1 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
2 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
3 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
4 International Myocarditis Registry Unknown status NCT01307735
5 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
6 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
7 CMR in Patients With Myocarditis Completed NCT01962584
8 Risk Factors for Predictors of In-hospital Death in Acute Fulminant Myocarditis Completed NCT03219996
9 Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With Myocarditis Completed NCT00693134
10 German Centre for Cardiovascular Research Cardiomyopathy Register Recruiting NCT02187263
11 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Not yet recruiting NCT02905721
12 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Not yet recruiting NCT02717143

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

39
Heart, T Cells, Cardiac Myocytes, Liver, Kidney, Myeloid

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 479)
id Title Authors Year
1
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
2
A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking. ( 28931401 )
2017
3
Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis. ( 28359509 )
2017
4
Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis. ( 28576783 )
2017
5
Sudden death and acute myocarditis: a unique forensic case of double origin of coronary arteries. ( 28928257 )
2017
6
Acute myocarditis secondary to cardiac tuberculosis: a case report. ( 28814447 )
2017
7
Established and novel treatment options in acute myocarditis, with or without heart failure. ( 27858465 )
2017
8
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis. ( 28887702 )
2017
9
Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. ( 28440472 )
2017
10
Ferumoxytol in acute myocarditis: 'keep your head in the clouds and your feet on the earth'. ( 28780574 )
2017
11
Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis. ( 28584814 )
2017
12
Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis: A case report treated with high doses (8a88mg/kg/d) of anakinra. ( 28614216 )
2017
13
Feature-tracking myocardial strain analysis in acute myocarditis: diagnostic value and association with myocardial oedema. ( 28500369 )
2017
14
Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK. ( 28410530 )
2017
15
Acute Myocarditis Secondary to Reactivated Chromosomally-Integrated Human Herpesvirus 6. ( 28522239 )
2017
16
Myocardial edema in acute myocarditis: relationship of T2 relaxometry and late enhancement burden by using dual-contrast turbo spin-echo MRI. ( 28528429 )
2017
17
Late Detection of Left Ventricular Dysfunction Using Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography in Patients with History of Nonsevere Acute Myocarditis. ( 28599827 )
2017
18
Acute Myocarditis Versus Ventricular Noncompaction Cardiomyopathy in Infancy: Role of Magnetic Resonance. ( 28528884 )
2017
19
Re-evaluation of a novel approach for quantitative myocardial oedema detection by analysing tissue inhomogeneity in acute myocarditis using T2-mapping. ( 28656464 )
2017
20
Predictive Value of Cardiac Magnetic Resonance Imaging-Derived Myocardial Strain for Poor Outcomes in Patients with Acute Myocarditis. ( 28670159 )
2017
21
Left and right ventricular morphology, function and late gadolinium enhancement extent and localization change with different clinical presentation of acute myocarditis Data from the ITAlian multicenter study on MYocarditis (ITAMY). ( 28915139 )
2017
22
Acute Myocarditis Due to Mushroom Ingestion. ( 28860035 )
2017
23
Incremental value of cardiac deformation analysis in acute myocarditis: a cardiovascular magnetic resonance imaging study. ( 27100527 )
2016
24
Persistent Atrial Standstill in Acute Myocarditis. ( 26897154 )
2016
25
Reply: Nondilated Left Ventricle as an Adding Clue Helping Discrimination Between Acute Myocarditis From OtherA Cardiomyopathies. ( 27737751 )
2016
26
Clinicodemographic features and outcome of acute myocarditis in children admitted at tertiary care hospital. ( 27400295 )
2016
27
The Prognostic Role of QTc Interval in Acute Myocarditis. ( 27122953 )
2016
28
Noninvasive imaging in acute myocarditis. ( 26731291 )
2016
29
Acute Myocarditis With Very High Troponin but No Ventricular Dysfunction. ( 27356633 )
2016
30
Comprehensive Cardiac Magnetic Resonance for Short-Term Follow-Up in Acute Myocarditis. ( 27436306 )
2016
31
Usefulness of Late Iodine Enhancement on Spectral CT in Acute Myocarditis. ( 28017385 )
2016
32
Improving outcomes of acute myocarditis in children. ( 26588165 )
2016
33
A Case of Thiopurine-Induced Acute Myocarditis in a Patient with Ulcerative Colitis. ( 27766449 )
2016
34
Acute myocarditis with normal wall motion detected with 2D speckle tracking echocardiography. ( 27249814 )
2016
35
Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus. ( 26922692 )
2016
36
Role of 18F-Fluorodeoxyglucose/Positron Emission Tomography Imaging to Demonstrate Resolution of Acute Myocarditis. ( 27923584 )
2016
37
Cardiac MRI and acute myocarditis. ( 28062736 )
2016
38
Left ventricular end-diastolic dimension as a predictive factor of outcomes in children with acute myocarditis. ( 27225897 )
2016
39
Prognostic value of the infarct- and non-infarct like patterns and cardiovascular magnetic resonance parameters on long-term outcome of patients after acute myocarditis. ( 27035605 )
2016
40
Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis. ( 27472894 )
2016
41
Acute Myocarditis and ST-Segment Elevation. ( 27742420 )
2016
42
Nondilated Left Ventricle as an Adding Clue Helping Discrimination Between Acute Myocarditis From Other Cardiomyopathies. ( 27737750 )
2016
43
Unusual Presentation of Dengue Fever: A child with acute myocarditis. ( 26909198 )
2016
44
A unique association of arrhythmogenic right ventricular dysplasia and acute myocarditis, as assessed by cardiac MRI: a case report. ( 27871237 )
2016
45
Myocardial fibrosis detected with Gadolinium Delayed Enhancement in Cardiac Magnetic Resonance Imaging and Ventriculoarterial Coupling alterations in patients with Acute Myocarditis. ( 28081949 )
2016
46
Veno-veno-arterial ECMO support for acute myocarditis combined with ARDS: a case report. ( 26847501 )
2016
47
Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis. ( 27913009 )
2016
48
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii. ( 27085128 )
2016
49
Value of novel cardiac magnetic resonance indices for the diagnosis of acute myocarditis: Left ventricular mechanics and parametric mapping imaging. ( 27584565 )
2016
50
Usefulness of Subepicardial Hyperemia on Contrast-Enhanced First-Pass Magnetic Resonance Perfusion Imaging for Diagnosis of Acute Myocarditis. ( 27296557 )
2016

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 CD40 CD70 FAS FASLG STAT1 TNC
2
Show member pathways
13.08 CD40 CD70 CD86 FASLG STAT1 TNFSF8
3
Show member pathways
13.06 CD40 CD70 FAS FASLG STAT1 TLR3
4
Show member pathways
13.04 CD40 CD70 FAS FASLG TNFSF8
5
Show member pathways
12.54 CD40 CD86 FAS FASLG STAT1
6
Show member pathways
12.53 FAS FASLG STAT1 TLR3
7
Show member pathways
12.51 CD40 CD86 FAS FASLG STAT1 TLR3
8 12.36 FAS FASLG STAT1 TLR3 TNC
9
Show member pathways
12.32 CD40 CD70 FAS FASLG STAT1
10 12.27 FAS FASLG STAT1 TLR3
11
Show member pathways
12.16 CD40 CD70 FAS FASLG TLR3 TNFSF8
12
Show member pathways
12.1 FAS FASLG STAT1
13
Show member pathways
12.04 FAS FASLG TLR3
14
Show member pathways
11.92 FAS FASLG STAT1
15
Show member pathways
11.72 CD86 STAT1 TLR3
16
Show member pathways
11.64 CD86 STAT1 TLR3
17 11.25 FAS FASLG
18
Show member pathways
11.21 FAS FASLG
19 11.14 FAS FASLG
20 11.1 CD40 CD86
21 11.03 CD40 CD70 CD86 TNFSF8
22 10.95 CD70 FASLG TNFSF8
23
Show member pathways
10.95 CD40 CD70 FAS FASLG TNFSF8

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 CD40 CD70 FAS FASLG TLR3 TNFSF8
2 external side of plasma membrane GO:0009897 9.26 CD40 CD86 FAS FASLG
3 cell surface GO:0009986 9.02 CD40 CD86 FAS FASLG TLR3

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.8 CD40 FAS TNC
2 cell-cell signaling GO:0007267 9.8 CD70 CD86 FASLG TNFSF8
3 immune response GO:0006955 9.8 CD40 CD70 CD86 FAS FASLG TNFSF8
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.75 CD40 FASLG TLR3
5 positive regulation of protein phosphorylation GO:0001934 9.74 CD40 FAS TLR3
6 response to lipopolysaccharide GO:0032496 9.73 CD40 CD86 FAS FASLG
7 defense response to virus GO:0051607 9.71 CD40 CD86 STAT1 TLR3
8 toll-like receptor signaling pathway GO:0002224 9.63 CD86 TLR3
9 cellular response to mechanical stimulus GO:0071260 9.63 CD40 FAS TLR3
10 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.61 FAS FASLG
11 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.61 FAS FASLG
12 B cell activation GO:0042113 9.6 CD40 CD86
13 response to interferon-gamma GO:0034341 9.59 CD40 CD86
14 positive regulation of interleukin-12 production GO:0032735 9.58 CD40 TLR3
15 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.56 FAS FASLG
16 apoptotic signaling pathway GO:0097190 9.56 CD40 FAS FASLG TLR3
17 necroptotic process GO:0070266 9.55 FASLG TLR3
18 positive regulation of endothelial cell apoptotic process GO:2000353 9.54 CD40 FASLG
19 cellular response to interferon-beta GO:0035458 9.52 STAT1 TLR3
20 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.51 FAS FASLG
21 toll-like receptor 3 signaling pathway GO:0034138 9.48 CD86 TLR3
22 extrinsic apoptotic signaling pathway GO:0097191 9.46 CD70 FAS FASLG TLR3
23 inflammatory cell apoptotic process GO:0006925 9.37 FAS FASLG
24 necroptotic signaling pathway GO:0097527 9.13 FAS FASLG TLR3
25 tumor necrosis factor-mediated signaling pathway GO:0033209 9.1 CD40 CD70 FAS FASLG STAT1 TNFSF8
26 signal transduction GO:0007165 10.09 CD70 FAS FASLG STAT1 TLR3 TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 CD70 FASLG TNFSF8
2 receptor binding GO:0005102 9.46 CD70 CD86 FASLG TNFSF8
3 tumor necrosis factor-activated receptor activity GO:0005031 9.26 CD40 FAS
4 receptor activity GO:0004872 9.26 CD40 CD86 FAS TLR3
5 tumor necrosis factor receptor binding GO:0005164 8.92 CD70 FASLG STAT1 TNFSF8

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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