MCID: ACT076
MIFTS: 47

Acute Myocarditis malady

Cardiovascular category

Summaries for Acute Myocarditis

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33MalaCards
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MalaCards: Acute Myocarditis is related to acute myocardial infarction and systemic lupus erythematosus. An important gene associated with Acute Myocarditis is TNC (tenascin C), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Regulation by c-FLIP. The compounds cycloheximide and ivig have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and heart, and related mouse phenotypes are vision/eye and liver/biliary system.

Aliases & Classifications for Acute Myocarditis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

acute myocarditis 8 45 61


External Ids:

Disease Ontology8 DOID:3951
ICD9CM27 422.90, 422
NCIt40 C35206
ICD1025 I40

Related Diseases for Acute Myocarditis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the myocarditis family:

acute myocarditis autoimmune myocarditis
infectious myocarditis post-infectious myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction30.9ACE, TXN, TNC, FABP3, FGA, ABCB7
2systemic lupus erythematosus30.4FAS, APOH, FASLG, FGA, CD70
3acute pancreatitis29.9ABCB7
4hepatitis c29.9TXN, ABCB7, FAS
5atrioventricular block10.5
6cardiogenic shock10.3
7infectious myocarditis10.2
8coronary artery vasospasm10.1
9hypertrophic cardiomyopathy10.1
10diastolic heart failure10.1
11pheochromocytoma10.1
12giant cell myocarditis10.1
13klebsiella10.1
14rubella10.0
15cardiac tamponade10.0
16bullous pemphigoid10.0
17reye syndrome10.0
18acute chest syndrome10.0
19diphtheria10.0
20erysipelas10.0
21atopic dermatitis10.0
22dengue hemorrhagic fever10.0
23chagas disease10.0
24appendicitis10.0
25whipple disease10.0
26parotitis10.0
27infectious mononucleosis10.0
28interstitial myocarditis10.0
29bulbar polio10.0
30churg-strauss syndrome10.0
31lateral myocardial infarction10.0
32kawasaki disease10.0
33n syndrome10.0
34chikungunya10.0
35japanese spotted fever10.0
36histoplasmosis pericarditis10.0
37mumps10.0
38hepatitis a10.0
39amyloidosis10.0
40smallpox10.0
41spotted fever10.0
42tetanus10.0
43autoimmune myocarditis10.0
44heart tumor10.0
45hemorrhagic fever10.0
46naxos disease10.0
47meningococcemia10.0
48polymyositis10.0
49image syndrome10.0
50syncope10.0

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Clinical Features for Acute Myocarditis

Drugs & Therapeutics for Acute Myocarditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Myocarditis

Drug clinical trials:

Search ClinicalTrials for Acute Myocarditis

Search NIH Clinical Center for Acute Myocarditis

Search CenterWatch for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Myocarditis:

33
Liver, Kidney, Heart, Pancreas, Tonsil, T cells, B lymphoblasts, B cells, Cardiac myocytes, Fetal liver

Animal Models for Acute Myocarditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Myocarditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.6PLAT, FABP3
2MP:00053708.1ABCB7, FGA, FABP3, FASLG, FAS, ACE
3MP:00053767.5TNC, APOH, FABP3, FGA, ABCB7, PLAT
4MP:00053857.3ACE, FAS, FASLG, FABP3, PROM1, FGA
5MP:00107686.0TXN, APOH, FAS, FASLG, FABP3, PROM1

Publications for Acute Myocarditis

Sources:
51PubMed
See all sources

Articles related to Acute Myocarditis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Acute toxic fulminant myocarditis after a black widow spider envenomation: case report and literature review. (23473466)
2013
2
Acute myocarditis presenting with ventricular arrhythmias: the role of CMR in the differential diagnosis of ARVD. (23994982)
2013
3
Value of magnetic resonance imaging on the diagnosis of acute myocarditis. (23526287)
2013
4
The utility of speckle tracking imaging in the diagnostic of acute myocarditis, as proven by endomyocardial biopsy. (23701925)
2013
5
Therapy with immunoglobulin in patients with acute myocarditis and cardiomyopathy: analysis of leukocyte balance. (23702697)
2013
6
Rapidly fatal community-acquired pneumonia due to Klebsiella pneumoniae complicated with acute myocarditis and accelerated idioventricular rhythm. (22153763)
2012
7
Sustained improvement of cardiac function with immunosuppressive therapy in a case of acute lymphocytic myocarditis secondary to allopurinol induced Stevens-Johnson syndrome. (23431692)
2012
8
A case of viral myocarditis presenting with acute asthma attack. (22719812)
2012
9
Acute necrotizing eosinophilic myocarditis in a young woman. (23089407)
2012
10
N-acetylcysteine suppresses the progression of ventricular remodeling in acute myocarditis: studies in an experimental autoimmune myocarditis (EAM) model. (21187656)
2011
11
Massive multi-chamber heart thrombosis as a consequence of acute fulminant myocarditis complicated with fatal ischaemic stroke. (21914701)
2011
12
Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditis. (22174827)
2011
13
Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome. (21860725)
2011
14
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. (19217318)
2010
15
Clinical outcome of acute myocarditis in children according to treatment modalities. (21189950)
2010
16
Acute pericarditis and myocarditis by Toxoplasma gondii in an immunocompetent young man: a case report. (20424527)
2010
17
Ultra long cardiopulmonary resuscitation with intact cerebral performance for an asystolic patient with acute myocarditis. (17234321)
2007
18
Immunity status against coxsackie viruses B in 25 patients with acute myocarditis. (18389726)
2006
19
Role of myocardial interstitial edema in conduction disturbances in acute myocarditis. (17143710)
2006
20
Focal myocardial fibrosis and edema in acute myocarditis demonstrated by multislice computed tomography. (16274784)
2005
21
Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. (15774612)
2005
22
Assessment of myocardial recovery in a patient with acute myocarditis supported with a left ventricular assist device: a case report. (12581771)
2003
23
The clinical course of acquired complete heart block in children with acute myocarditis. (14627323)
2003
24
Ultrasonic tissue characterization in acute myocarditis: a case report. (11954960)
2002
25
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
26
Fatal acute myocarditis in an infant with human herpesvirus 6 infection. (11577130)
2001
27
Transient ventricular wall thickening in acute myocarditis: a serial echocardiographic and histopathologic study. (11665789)
2001
28
T wave alternans and acute rheumatic myocarditis: a case report. (10575535)
1999
29
Dynamic outflow obstruction due to the transient extensive left ventricular wall motion abnormalities caused by acute myocarditis in a patient with hypertrophic cardiomyopathy: reduction in ventricular afterload by disopyramide. (10478816)
1999
30
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
31
Evaluation of acute myocarditis and pericarditis by Gd-DTPA enhanced magnetic resonance imaging. (8005133)
1994
32
T-cell receptor V beta gene expression in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3. (8181142)
1994
33
Usefulness of magnetic resonance imaging for diagnosis of acute myocarditis in infants and children, and comparison with endomyocardial biopsy. (1927924)
1991
34
Immunosuppressive therapy in the management of acute myocarditis in children: a clinical trial. (1991904)
1991
35
Transient myocardial thickening in acute myocarditis--serial study by two-dimensional echocardiography. (2516702)
1989
36
Sudden increase in left ventricular mass secondary to acute myocarditis. (2969183)
1988
37
Acute myocarditis in a captive African elephant (Loxodonta africana). (3820423)
1987
38
Increased osmotic fragility of red cells in dogs with acute myocarditis produced by scorpion (Buthus tamulus) venom. (3557611)
1986
39
A long-term follow-up study of acute myocarditis an electrocardiographic and echocardiographic study. (6542598)
1984
40
Ventriculographic findings in the convalescent stage in eleven cases with acute myocarditis. (6685784)
1983
41
Arbovirus (dengue type) as a cause of acute myocarditis and pericarditis. (4266127)
1973
42
Clinical briefs. Acute myocarditis simulating myocardial infarction. (5131337)
1971
43
The intracardiac pacemaker in acute rheumatic myocarditis. (5343530)
1969
44
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
45
ACUTE MYOCARDITIS IN THE ADULT. (14214812)
1964
46
Acute myocarditis in sudden and unexpected death. (13254525)
1955
47
Alterations of the lesions of acute rheumatic myocarditis during cortisone therapy. (13019937)
1953
48
Acute myocarditis; report of a case with observations on the etiologic factor. (15399491)
1950
49
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946
50
Acute myocarditis as a sequel to infectious mononucleosis. (20286801)
1946

Genetic Variations for Acute Myocarditis

Expression for genes affiliated with Acute Myocarditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

Sources:
53R&D Systems, 54Reactome, 12EMD Millipore, 56SinoBiological, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Acute Myocarditis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Acute Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5FASLG
2ivig4510.5APOH
3(glc)44510.1FAS, FASLG
411-dehydrothromboxane b24510.0FGA, APOH
5an 69459.9FGA, ACE
6desirudin459.9FGA, PLAT
7atpo45 2910.8FAS, FASLG, APOH
8fibrinopeptide a459.8FGA, PLAT
9batroxobin459.8FGA, PLAT
10ancrod459.8PLAT, FGA
11palmitate459.8TXN
12delapril459.7ACE, PLAT
13bivalirudin45 1110.7FGA, PLAT
14manidipine459.7PLAT, ACE
15argatroban45 1110.7FGA, PLAT
16selenodiglutathione459.6TXN, FAS
17omapatrilat459.6PLAT, ACE
18glutamate459.6PLAT, ABCB7, APOH
19ticlopidine45 1110.6APOH, FGA, PLAT
20ptca459.6APOH, PLAT, FGA
21thromboxane45 2410.5PLAT, APOH, FGA
22p002459.5FABP3, PLAT, APOH, TNC
23thromboxane a245 2410.4APOH, FGA, PLAT
24enalaprilat459.4PLAT, ACE
25ppack459.4FGA, PLAT
26kininogen459.4ACE, APOH, PLAT
27glucose459.3PLAT, FASLG, APOH, FABP3
28quinapril45 1110.3PLAT, ACE
29suberoylanilide hydroxamic acid459.3FASLG, TXN, FAS
30daunorubicin45 50 1111.2FAS, FASLG, TXN
31p003459.2FABP3, FASLG, APOH, TNC, PLAT
32mitomycin c459.2TXN, FASLG, FAS
33heparin45 29 11 2412.1ABCB7, APOH, FAS, FASLG, FGA
34warfarin45 50 11 2412.1ACE, APOH, FGA, PLAT
35prostacyclin459.0PLAT, ACE, APOH, FGA
36fibrinogen459.0PLAT, TNC, APOH, ABCB7, FGA
37progesterone45 60 29 11 2413.0FASLG, PLAT, ABCB7, TNC, APOH
38paraffin458.9FAS, TNC, FASLG, PLAT
39sodium nitroprusside458.8PLAT, FASLG, FAS
40pge1458.8PLAT, TXN, APOH, FGA
41nitric oxide45 11 2410.7FAS, FASLG, APOH, ACE, ABCB7
42aspirin45 50 29 2411.6ACE, PLAT, APOH, FGA, FAS
43vegf458.6FAS, FASLG, TNC, APOH, TXN
44ascorbic acid45 249.5TXN, TNC, FAS, FASLG, PLAT
45actinomycin d458.4PLAT, FAS, TNC, TXN, FASLG
46lipid458.4TNC, APOH, FABP3, PROM1, FGA, ABCB7
47aspartate458.3PLAT, ABCB7, FASLG, TXN, FAS
48cholesterol45 29 11 2411.2APOH, FGA, ABCB7, PLAT, ACE, FABP3
49lactate458.1FGA, FABP3, ABCB7, TXN, APOH, FASLG
50creatinine457.0APOH, TXN, TNC, FABP3, FGA, ABCB7

GO Terms for genes affiliated with Acute Myocarditis

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.3PLAT, APOH, TNC
2external side of plasma membraneGO:0098978.8FAS, FASLG, FGA, ACE
3cell surfaceGO:0099868.4APOH, PROM1, FGA, PLAT
4extracellular regionGO:0055767.0TXN, TNC, FAS, FASLG, FGA, PLAT
5extracellular spaceGO:0056157.0ACE, TNC, TNFSF8, APOH, FASLG, PROM1

Biological processes related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.8FASLG, FAS
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.7FASLG, FAS
3plasminogen activationGO:0316399.4PLAT, APOH
4cellular response to hyperoxiaGO:0714559.2TXN, FAS
5cell-cell signalingGO:0072678.3CD70, FASLG, TNFSF8, TXN
6signal transductionGO:0071657.8FGA, CD70, FASLG, FAS, TNFSF8, TXN

Molecular functions related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.4CD70, FASLG, TNFSF8
2cytokine activityGO:0051259.4CD70, FASLG, TNFSF8
3receptor bindingGO:0051028.7TNFSF8, FASLG, CD70, FGA
4protein bindingGO:0055155.5TXN, APOH, FAS, FASLG, FABP3, PROM1

Products for genes affiliated with Acute Myocarditis

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  • Lysates
  • Antibodies

Sources for Acute Myocarditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet