MCID: ACT076
MIFTS: 48

Acute Myocarditis

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Acute Myocarditis

MalaCards integrated aliases for Acute Myocarditis:

Name: Acute Myocarditis 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3951
ICD10 32 I40 I40.9
ICD9CM 34 422 422.90
NCIt 46 C35206
UMLS 69 C0155686

Summaries for Acute Myocarditis

MalaCards based summary : Acute Myocarditis is related to myocarditis and systemic lupus erythematosus. An important gene associated with Acute Myocarditis is TLR3 (Toll Like Receptor 3), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. The drugs Ferrosoferric Oxide and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and cardiac myocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Acute Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 myocarditis 30.9 CD40 CD86 TNNI3
2 systemic lupus erythematosus 28.5 CD40 CD70 CD86 FAS FASLG STAT1
3 giant cell myocarditis 10.6
4 myocardial infarction 10.3
5 penicilliosis 10.2 CD40 CD86
6 exanthema subitum 10.2 CD40 CD86
7 type ii mixed cryoglobulinemia 10.2 FAS FASLG
8 keloids 10.2 FAS TNC
9 acute myocardial infarction 10.2
10 lymphocytic gastritis 10.2 FAS FASLG
11 autoimmune disease of central nervous system 10.1 CD86 TNFSF8
12 lymphomatoid papulosis 10.1 FAS FASLG
13 dilated cardiomyopathy 10.1
14 cartilage-hair hypoplasia 10.1 FAS FASLG
15 fiedler's myocarditis 10.1
16 septic myocarditis 10.1
17 atrioventricular block 10.1
18 japanese encephalitis 10.1 STAT1 TLR3
19 hydrops, lactic acidosis, and sideroblastic anemia 10.0
20 epstein-barr virus-associated gastric carcinoma 10.0 FAS FASLG
21 influenza 10.0
22 severe cutaneous adverse reaction 10.0 FAS FASLG TLR3
23 aneurysm 10.0
24 brain glioma 9.9 FAS FASLG
25 hashimoto thyroiditis 9.9 CD40 FAS FASLG
26 lupus erythematosus 9.9
27 cardiogenic shock 9.9
28 graves' disease 9.9 CD40 FAS FASLG
29 atrial standstill 1 9.9
30 episodic pain syndrome, familial, 1 9.9
31 pericarditis 9.9
32 central nervous system tuberculosis 9.8 FAS FASLG STAT1
33 fibrosis of extraocular muscles, congenital, 1 9.8
34 cardiomyopathy, familial hypertrophic, 1 9.8
35 aging 9.8
36 pneumonia 9.8
37 lymphoma, non-hodgkin, familial 9.8 CD40 FAS TNFSF8
38 common variable immunodeficiency 9.8 CD40 CD70 CD86 FAS
39 pheochromocytoma 9.7
40 ventricular fibrillation, paroxysmal familial, 1 9.7
41 wegener granulomatosis 9.7
42 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7
43 malaria 9.7
44 cardiac tamponade 9.7
45 coronary artery vasospasm 9.7
46 hypertrophic cardiomyopathy 9.7
47 parametritis 9.7
48 myopathy 9.7
49 diastolic heart failure 9.7
50 extrinsic cardiomyopathy 9.7 TLR3 TNNI3

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to Acute Myocarditis

Symptoms & Phenotypes for Acute Myocarditis

GenomeRNAi Phenotypes related to Acute Myocarditis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD70 FAS STAT1 TNFSF8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CD40 CD70 FAS FASLG STAT1 TNFSF8
3 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 9.26 CD70 CD86 SDHA TNNI3

MGI Mouse Phenotypes related to Acute Myocarditis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 STAT1 TLR3 CD40 CD86 FAS FASLG
2 hematopoietic system MP:0005397 9.7 STAT1 TLR3 CD40 CD70 CD86 FAS
3 homeostasis/metabolism MP:0005376 9.56 STAT1 TLR3 TNC CD40 CD86 FAS
4 immune system MP:0005387 9.23 TLR3 TNFSF8 CD40 CD70 CD86 FAS

Drugs & Therapeutics for Acute Myocarditis

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ferrosoferric Oxide Phase 2, Phase 3
2 Hematinics Phase 2, Phase 3
3 Parenteral Nutrition Solutions Phase 2, Phase 3
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Adrenergic Agents Phase 2, Phase 3
6 Adrenergic Antagonists Phase 2, Phase 3
7 Adrenergic beta-Antagonists Phase 2, Phase 3
8 Antirheumatic Agents Phase 2, Phase 3
9 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
10 Neurotransmitter Agents Phase 2, Phase 3
11
Iodine Approved, Investigational 7553-56-2 807
12
Octreotide Approved, Investigational 83150-76-9 6400441 383414
13
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
14 cadexomer iodine
15 Antineoplastic Agents, Hormonal
16 Edotreotide
17 Gastrointestinal Agents
18 Hormone Antagonists
19 Hormones
20 Hormones, Hormone Substitutes, and Hormone Antagonists
21 Radiopharmaceuticals

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 DEtection of Cellular Inflammation With FERumoxytol in the HEART Completed NCT02319278 Phase 2, Phase 3 Ferumoxytol
2 Anakinra Versus Placebo for the Treatment of Acute MyocarditIS Recruiting NCT03018834 Phase 2, Phase 3 ANAKINRA 100 mg/daily subcutaneously;Placebo
3 Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC) Active, not recruiting NCT02293603 Phase 1
4 International Myocarditis Registry Unknown status NCT01307735
5 German Centre for Cardiovascular Research Cardiomyopathy Register Unknown status NCT02187263
6 Cardiac Magnetic Resonance in Acute Myocarditis Completed NCT02299856
7 CMR in Patients With Myocarditis Completed NCT01962584
8 Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis Recruiting NCT02905721
9 French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI Recruiting NCT02717143
10 Impella CP With VA ECMO for Cardiogenic Shock Not yet recruiting NCT03431467
11 Pilot Study Evaluating Somatostatin Receptor's PET Imaging to Detect Inflammatory Phases of Myocarditis Not yet recruiting NCT03347760 DOTATOC-68Ga PET initial;DOTATOC-68Ga PET at 6 months

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

Anatomical Context for Acute Myocarditis

MalaCards organs/tissues related to Acute Myocarditis:

38
Heart, T Cells, Cardiac Myocytes, Liver, Kidney, Myeloid

Publications for Acute Myocarditis

Articles related to Acute Myocarditis:

(show top 50) (show all 492)
# Title Authors Year
1
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis. ( 29039143 )
2018
2
Anthracycline-induced acute myocarditis and ventricular fibrillation arrest. ( 29194712 )
2018
3
Electrocardiographic Predictors of Morbidity and Mortality in Patients With Acute Myocarditis: The Importance of QRS-T Angle. ( 29158065 )
2018
4
Acute Myocarditis with Infarct-like Presentation in a Pediatric Population: Role of Cardiovascular Magnetic Resonance. ( 28986648 )
2018
5
Acute myocarditis secondary to acute<i>Campylobacter jejuni</i>infection. ( 29436448 )
2018
6
The search for water: Is it so easy to diagnose acute myocarditis? ( 29435861 )
2018
7
Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis. ( 28986407 )
2018
8
Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. ( 28226202 )
2017
9
Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK. ( 28410530 )
2017
10
Cardiac MR With Late Gadolinium Enhancement in Acute Myocarditis WithA Preserved Systolic Function: ITAMY Study. ( 29025554 )
2017
11
Ferumoxytol in acute myocarditis: 'keep your head in the clouds and your feet on the earth'. ( 28780574 )
2017
12
Sudden death and acute myocarditis: a unique forensic case of double origin of coronary arteries. ( 28928257 )
2017
13
Predictors of Extracorporeal Membrane Oxygenation Support for Children with Acute Myocarditis. ( 28584814 )
2017
14
Contemporary Postnatal Incidence of Acquiring Acute Myocarditis by Age 15 Years and the Outcomes From a Nationwide Birth Cohort. ( 29068909 )
2017
15
Myocardial edema in acute myocarditis: relationship of T2 relaxometry and late enhancement burden by using dual-contrast turbo spin-echo MRI. ( 28528429 )
2017
16
Established and novel treatment options in acute myocarditis, with or without heart failure. ( 27858465 )
2017
17
Left and right ventricular morphology, function and late gadolinium enhancement extent and localization change with different clinical presentation of acute myocarditis Data from the ITAlian multicenter study on MYocarditis (ITAMY). ( 28915139 )
2017
18
Value of SOFA, APACHE IV and SAPS II scoring systems in predicting short-term mortality in patients with acute myocarditis. ( 28968972 )
2017
19
Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis. ( 28440472 )
2017
20
Heart Failure and Mortality of Adult Survivors from Acute Myocarditis Requiring Intensive Care Treatment - A Nationwide Cohort Study. ( 29104480 )
2017
21
A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking. ( 28931401 )
2017
22
Predictive Value of Cardiac Magnetic Resonance Imaging-Derived Myocardial Strain for Poor Outcomes in Patients with Acute Myocarditis. ( 28670159 )
2017
23
Acute myocarditis secondary to cardiac tuberculosis: a case report. ( 28814447 )
2017
24
Acute Myocarditis Due to Mushroom Ingestion. ( 28860035 )
2017
25
Assessment of acute myocarditis by cardiac magnetic resonance imaging: Comparison of qualitative and quantitative analysis methods. ( 29076052 )
2017
26
Acute Myocarditis Secondary to Reactivated Chromosomally-Integrated Human Herpesvirus 6. ( 28522239 )
2017
27
Feature-tracking myocardial strain analysis in acute myocarditis: diagnostic value and association with myocardial oedema. ( 28500369 )
2017
28
Late Detection of Left Ventricular Dysfunction Using Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography in Patients with History of Nonsevere Acute Myocarditis. ( 28599827 )
2017
29
Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis: A case report treated with high doses (8a88mg/kg/d) of anakinra. ( 28614216 )
2017
30
Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis. ( 28359509 )
2017
31
Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis. ( 28576783 )
2017
32
Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis. ( 28887702 )
2017
33
Re-evaluation of a novel approach for quantitative myocardial oedema detection by analysing tissue inhomogeneity in acute myocarditis using T2-mapping. ( 28656464 )
2017
34
Acute Myocarditis Versus Ventricular Noncompaction Cardiomyopathy in Infancy: Role of Magnetic Resonance. ( 28528884 )
2017
35
A unique association of arrhythmogenic right ventricular dysplasia and acute myocarditis, as assessed by cardiac MRI: a case report. ( 27871237 )
2016
36
Improving outcomes of acute myocarditis in children. ( 26588165 )
2016
37
Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis. ( 27472894 )
2016
38
Usefulness of Subepicardial Hyperemia on Contrast-Enhanced First-Pass Magnetic Resonance Perfusion Imaging for Diagnosis of Acute Myocarditis. ( 27296557 )
2016
39
Acute Myocarditis With Very High Troponin but No Ventricular Dysfunction. ( 27356633 )
2016
40
Acute Myocarditis and ST-Segment Elevation. ( 27742420 )
2016
41
Role of 18F-Fluorodeoxyglucose/Positron Emission Tomography Imaging to Demonstrate Resolution of Acute Myocarditis. ( 27923584 )
2016
42
Incremental value of cardiac deformation analysis in acute myocarditis: a cardiovascular magnetic resonance imaging study. ( 27100527 )
2016
43
Myocardial fibrosis detected with Gadolinium Delayed Enhancement in Cardiac Magnetic Resonance Imaging and Ventriculoarterial Coupling alterations in patients with Acute Myocarditis. ( 28081949 )
2016
44
Nondilated Left Ventricle as an Adding Clue Helping Discrimination Between Acute Myocarditis From Other Cardiomyopathies. ( 27737750 )
2016
45
Value of novel cardiac magnetic resonance indices for the diagnosis of acute myocarditis: Left ventricular mechanics and parametric mapping imaging. ( 27584565 )
2016
46
Comprehensive Cardiac Magnetic Resonance for Short-Term Follow-Up in Acute Myocarditis. ( 27436306 )
2016
47
Veno-veno-arterial ECMO support for acute myocarditis combined with ARDS: a case report. ( 26847501 )
2016
48
Immunosuppressive Therapy and Interferon-1I^ in Acute Myocarditis. ( 27514623 )
2016
49
Left ventricular end-diastolic dimension as a predictive factor of outcomes in children with acute myocarditis. ( 27225897 )
2016
50
Acute myocarditis in an immunocompetent young man: Don't forget Toxoplasma gondii. ( 27085128 )
2016

Variations for Acute Myocarditis

Expression for Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for Acute Myocarditis

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 CD40 CD70 FAS FASLG STAT1 TNC
2
Show member pathways
13.1 CD40 CD70 CD86 FASLG STAT1 TNFSF8
3
Show member pathways
13.09 CD40 CD70 FAS FASLG STAT1 TLR3
4
Show member pathways
13.06 CD40 CD70 FAS FASLG TNFSF8
5
Show member pathways
12.7 FAS FASLG STAT1 TLR3 TNC
6
Show member pathways
12.6 CD40 CD86 FAS FASLG STAT1
7
Show member pathways
12.56 FAS FASLG STAT1 TLR3
8
Show member pathways
12.36 CD40 CD70 FAS FASLG STAT1
9 12.34 FAS FASLG STAT1 TLR3
10
Show member pathways
12.26 CD40 CD70 FAS FASLG TLR3 TNFSF8
11
Show member pathways
12.24 CD86 FAS FASLG STAT1 TLR3
12
Show member pathways
12.12 FAS FASLG STAT1
13
Show member pathways
12.07 FAS FASLG TLR3
14
Show member pathways
11.98 FAS FASLG STAT1 TLR3
15
Show member pathways
11.95 FAS FASLG STAT1
16
Show member pathways
11.92 CD40 CD86 FAS FASLG STAT1 TLR3
17
Show member pathways
11.73 CD86 STAT1 TLR3
18
Show member pathways
11.63 CD86 STAT1 TLR3
19 11.27 FAS FASLG
20 11.22 CD40 CD70 CD86 TNFSF8
21
Show member pathways
11.18 FAS FASLG
22 11.16 FAS FASLG
23 11.12 CD40 CD86
24 10.98 CD70 FASLG TNFSF8
25
Show member pathways
10.94 CD40 CD70 FAS FASLG TNFSF8
26 10.79 CD70 FASLG TNC TNFSF8

GO Terms for Acute Myocarditis

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 CD40 CD70 FAS FASLG TLR3 TNFSF8
2 cell surface GO:0009986 9.02 CD40 CD86 FAS FASLG TLR3

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.95 CD70 CD86 FAS FASLG STAT1 TLR3
2 apoptotic process GO:0006915 9.91 FAS FASLG STAT1 TNFSF8
3 positive regulation of cell proliferation GO:0008284 9.87 CD86 FASLG STAT1 TNC
4 immune response GO:0006955 9.8 CD40 CD70 CD86 FAS FASLG TNFSF8
5 regulation of cell proliferation GO:0042127 9.77 CD40 FAS TNC
6 response to lipopolysaccharide GO:0032496 9.76 CD40 FAS FASLG
7 defense response to virus GO:0051607 9.75 CD40 STAT1 TLR3
8 cell-cell signaling GO:0007267 9.73 CD70 CD86 FASLG TNFSF8
9 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.72 CD40 FASLG TLR3
10 positive regulation of protein phosphorylation GO:0001934 9.71 CD40 FAS TLR3
11 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.59 FAS FASLG
12 positive regulation of interleukin-12 production GO:0032735 9.56 CD40 TLR3
13 apoptotic signaling pathway GO:0097190 9.56 CD40 FAS FASLG TLR3
14 cellular response to mechanical stimulus GO:0071260 9.54 CD40 FAS TLR3
15 positive regulation of endothelial cell apoptotic process GO:2000353 9.52 CD40 FASLG
16 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.51 FAS FASLG
17 necroptotic process GO:0070266 9.49 FASLG TLR3
18 cellular response to interferon-beta GO:0035458 9.48 STAT1 TLR3
19 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.46 FAS FASLG
20 extrinsic apoptotic signaling pathway GO:0097191 9.46 CD70 FAS FASLG TLR3
21 necroptotic signaling pathway GO:0097527 9.13 FAS FASLG TLR3
22 tumor necrosis factor-mediated signaling pathway GO:0033209 9.1 CD40 CD70 FAS FASLG STAT1 TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CD70 FASLG TNFSF8
2 receptor activity GO:0004872 9.26 CD40 CD86 FAS TLR3
3 tumor necrosis factor-activated receptor activity GO:0005031 9.16 CD40 FAS
4 tumor necrosis factor receptor binding GO:0005164 8.92 CD70 FASLG STAT1 TNFSF8

Sources for Acute Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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