MCID: ACT076
MIFTS: 40

Acute Myocarditis malady

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Acute Myocarditis

About this section

Aliases & Descriptions for Acute Myocarditis:

Name: Acute Myocarditis 11 13 48 66

Classifications:



External Ids:

Disease Ontology11 DOID:3951
ICD1028 I40, I40.9
ICD9CM30 422, 422.90
NCIt43 C35206

Summaries for Acute Myocarditis

About this section
MalaCards based summary: Acute Myocarditis is related to pediatric systemic lupus erythematosus and systemic lupus erythematosus. An important gene associated with Acute Myocarditis is FASLG (Fas Ligand), and among its related pathways are Inflammatory Response Pathway and African trypanosomiasis. Affiliated tissues include heart, t cells and cardiac myocytes, and related mouse phenotype immune system.

Related Diseases for Acute Myocarditis

About this section

Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1pediatric systemic lupus erythematosus30.2FAS, FASLG
2systemic lupus erythematosus29.6CD40, CD86, FAS, FASLG
3myocarditis10.9
4giant cell myocarditis10.6
512p12.1 microdeletion syndrome10.6FAS, FASLG
6granulomatous gastritis10.5FAS, FASLG
7metaphyseal dysplasia without hypotrichosis10.5FAS, FASLG
8steroid dehydrogenase deficiency dental anomalies10.4FAS, FASLG
9benign breast adenomyoepithelioma10.4FAS, FASLG
10trichosporonosis10.3CD40, CD86
11myocardial infarction10.3
12cardiomyopathy10.3
13spinal polio10.3CD40, CD86
14fiedler's myocarditis10.3
15artemis deficiency10.2CD86, TNFSF8
16spondyloarthropathy 110.2FAS, FASLG
17acute myocardial infarction10.2
18longitudinal vaginal septum10.2SDHA, TNNI3
19dilated cardiomyopathy10.2
20atrioventricular block10.1
21bacteriuria10.1CD40, CD86
22lacrimal system cancer10.1ACE, FAS
23colon carcinoma in situ10.1ACE, TNNI3
24septic myocarditis10.1
25sinusitis10.1ACE, FAS, FASLG
26oesophagostomiasis10.0ACE, TNNI3
27influenza10.0
28congenital symblepharon10.0CD40, CD86, FAS
29aneurysm10.0
30lupus erythematosus10.0
31cardiogenic shock10.0
32pericarditis9.9
33sacral spinal canal and spinal cord meningioma9.9ACE, CD40, CD86
34smoking as a quantitative trait locus 19.9CD40, FAS, TNFSF8
35adams-oliver syndrome 59.9ACE, TNNI3
36pneumonia9.9
37eosinophilia9.9
38primary polycythemia9.8ACE, CUX2
39autoimmune disease of skin and connective tissue9.8ACE, TNNI3
40pheochromocytoma9.8
41malaria9.8
42cardiac tamponade9.8
43coronary artery vasospasm9.8
44hypertrophic cardiomyopathy9.8
45parametritis9.8
46myopathy9.8
47diastolic heart failure9.8
48naxos disease9.6
49kawasaki disease9.6
50crohn's disease9.6

Comorbidity relations with Acute Myocarditis via Phenotypic Disease Network (PDN):


Ischemic Heart DiseaseHeart Disease

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Symptoms for Acute Myocarditis

About this section

Drugs & Therapeutics for Acute Myocarditis

About this section

Drugs for Acute Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronPhase 210807439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
 
Ed-In-Sol
Eisen
Electrolytic iron
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feronate
Ferretts
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
Ferrum metallicum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron powder
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, carbonyl
Iron, electrolytic
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
Iron, reduced
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Reduced iron
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Vitedyn-Slo
Yieronia
fer
ferrous iron
hierro
2
protease inhibitors5157
Synonyms:
 
protease inhibitors
3
Iodine5167553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
4cadexomer iodine484

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1DEtection of Cellular Inflammation With FERumoxytol in the HEARTRecruitingNCT02319278Phase 2, Phase 3
2IRon Nanoparticle Enhanced MRI in the Assessment of Myocardial infarctioNRecruitingNCT01995799Phase 2
3Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)Active, not recruitingNCT02293603Phase 1
4Cardiac Magnetic Resonance in Acute MyocarditisCompletedNCT02299856
5CMR in Patients With MyocarditisCompletedNCT01962584
6Role of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinases (TIMPs) in Children With MyocarditisCompletedNCT00693134
7Detection of Enterovirus RNA in Atheromatous LesionsCompletedNCT00674531
8German Centre for Cardiovascular Research Cardiomyopathy RegisterRecruitingNCT02187263
9Short and Long Term Outcomes of Acute Coronary Syndrome in Patients With Non Obstructive Coronary AtherosclerosisRecruitingNCT02655718
10Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) PatientsRecruitingNCT01089036
11Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR ImagingRecruitingNCT02527330
12Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Study on Diagnosis Made by Cardiac MRIRecruitingNCT02318498
13Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
14Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden DeathRecruitingNCT01919983
15International Myocarditis RegistryEnrolling by invitationNCT01307735
16Evaluation of Spectral Cardiac CT for the Diagnosis of Acute MyocarditisNot yet recruitingNCT02905721
17French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRINot yet recruitingNCT02717143
18Transient ECG Changes in Patients With Acute Biliary DiseaseNot yet recruitingNCT01706068

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

About this section

Anatomical Context for Acute Myocarditis

About this section

MalaCards organs/tissues related to Acute Myocarditis:

34
Heart, T cells, Cardiac myocytes, Liver, Kidney, Myeloid

Animal Models for Acute Myocarditis or affiliated genes

About this section

MGI Mouse Phenotypes related to Acute Myocarditis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6ACE, CD40, CD86, DMGDH, FAS, FASLG

Publications for Acute Myocarditis

About this section

Articles related to Acute Myocarditis:

(show top 50)    (show all 447)
idTitleAuthorsYear
1
Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis. (27472894)
2016
2
Relationship between T-wave inversion and transmural myocardial edema as evidenced by cardiac magnetic resonance in patients with clinically suspected acute myocarditis: clinical and prognostic implications. (27178316)
2016
3
Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus. (26922692)
2016
4
Diagnostic implications of magnetic resonance feature tracking derived myocardial strain parameters in acute myocarditis. (26724669)
2016
5
Atrial Fibrillation Due to Acute Myocarditis During Dengue Haemorrhagic Fever. (26500943)
2015
6
Diagnosis of acute myocarditis with dual source cardiac tomography. (25464460)
2015
7
High-degree atrioventricular block in a child with acute myocarditis. (24940135)
2014
8
Acute myocarditis associated with coxsackievirus b4 mimicking influenza myocarditis: electron microscopy detection of causal virus of myocarditis. (24366591)
2013
9
Electrocardiographic findings and myocardial damage in acute myocarditis detected by cardiac magnetic resonance. (22388951)
2012
10
The contribution of MRI in the diagnosis of acute myocarditis following a spider bite: a case report. (23102751)
2012
11
Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy. (21422001)
2011
12
Acute myocarditis after urinary tract infection by Escherichia coli. (21094538)
2011
13
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. (19217318)
2010
14
A case of acute myocarditis caused by pandemic (H1N1) 2009 influenza virus. (21126658)
2010
15
Parvovirus B19 profiles in patients presenting with acute myocarditis and chronic dilated cardiomyopathy. (19043365)
2008
16
Late enhancement detected by cardiac magnetic resonance imaging in acute myocarditis mimicking acute myocardial infarction: location patterns and lack of correlation with systolic function. (18163015)
2007
17
Diagnostic value of ECG-gated multidetector computed tomography in the early phase of suspected acute myocarditis. A preliminary comparative study with cardiac MRI. (16953372)
2007
18
Muronomab-CD3 for pediatric acute myocarditis. (17165111)
2007
19
Immunity status against coxsackie viruses B in 25 patients with acute myocarditis. (18389726)
2006
20
Acute myocarditis and myocardial infarction induced by Paraphenylenediamine poisoning. Interest of angiocoronarography. (16890306)
2006
21
Short-term prognostic value of initial serum levels of interleukin-10 in patients with acute myocarditis. (15642541)
2005
22
Transatrial resection of a left ventricular thrombus after acute myocarditis. (16160906)
2005
23
Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. (15306225)
2004
24
Long-term follow-up of patients paragraph sign with acute myocarditis by magnetic paragraph sign resonance imaging. (12695882)
2003
25
Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (12031769)
2002
26
High-dose intravenous immunoglobulin in the treatment of acute myocarditis. A case report and review of the literature. (11905592)
2002
27
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
28
Acute myocarditis and left ventricular "hypertrophy". (11000592)
2000
29
Predictors of disease course in patients with acute myocarditis. (11104740)
2000
30
Cardiac dendritic cells and acute myocarditis in the human heart. (10651208)
2000
31
Intrapericardial yolk sac tumor associated with acute myocarditis. (10086513)
1999
32
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
33
Temporary mechanical support with the BVS 5000 assist device during treatment of acute myocarditis. (9169372)
1997
34
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
35
Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. (7635939)
1995
36
Usefulness of magnetic resonance imaging for diagnosis of acute myocarditis in infants and children, and comparison with endomyocardial biopsy. (1927924)
1991
37
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
38
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
39
Increase in serum free fatty acids, phospholipids and reduction in total cholesterol in acute myocarditis produced by scorpion (Buthus tamulus) venom injection in dogs. (3570321)
1986
40
A long-term follow-up study of acute myocarditis an electrocardiographic and echocardiographic study. (6542598)
1984
41
Intense, persistent myocardial avid technetium-99m-pyrophosphate scintigraphy in acute myocarditis. (6261571)
1981
42
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
43
Coxsackie B5 virus responsible for acute myocarditis inucklings. (5439221)
1970
44
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
45
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
46
EFFECTS OF MUSCULAR ACTIVITY UPON THE ACUTE MYOCARDITIS OF C3H MICE INFECTED WITH TRYPANOSOMA CRUZI. (14280104)
1965
47
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
48
Transient electrocardiographic changes simulating an acute myocarditis in serum sickness. (13065994)
1953
49
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946
50
A CASE OF DIPHTHERIAL ACUTE MYOCARDITIS STUDIED BY MEANS OF THE PORTABLE ELECTRO-CARDIOGRAPH. (20775498)
1930

Variations for Acute Myocarditis

About this section

Expression for genes affiliated with Acute Myocarditis

About this section
Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

About this section

Pathways related to Acute Myocarditis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8CD40, CD86
29.8FAS, FASLG
3
Show member pathways
9.8FAS, FASLG
49.8FAS, FASLG
59.7ACE, CD40
69.3CD40, CD86, TNFSF8
7
Show member pathways
9.1CD40, CD86, FAS, FASLG
8
Show member pathways
9.0CD40, FAS, FASLG, TNFSF8
9
Show member pathways
9.0CD40, FAS, FASLG, TNFSF8
10
Show member pathways
8.6ACE, CD40, CD86, FAS, FASLG

GO Terms for genes affiliated with Acute Myocarditis

About this section

Cellular components related to Acute Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9ACE, CD40, CD86, FAS, FASLG
2cell surfaceGO:00099868.8CD40, CD86, FAS, FASLG
3extracellular spaceGO:00056158.1ACE, CD40, FAS, FASLG, TNC, TNFSF8

Biological processes related to Acute Myocarditis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.5FAS, FASLG
2necroptotic signaling pathwayGO:009752710.4FAS, FASLG
3positive regulation of endothelial cell apoptotic processGO:200035310.4CD40, FASLG
4activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.4FAS, FASLG
5response to growth factorGO:007084810.4FAS, FASLG
6regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.3FAS, FASLG
7extrinsic apoptotic signaling pathwayGO:009719110.3FAS, FASLG
8negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.2FAS, FASLG
9B cell activationGO:004211310.1CD40, CD86
10extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.9FAS, FASLG
11cell-cell signalingGO:00072679.4CD86, FASLG, TNFSF8
12apoptotic signaling pathwayGO:00971909.4CD40, FAS, FASLG
13heart contractionGO:00600479.2ACE, TNNI3
14response to lipopolysaccharideGO:00324969.1CD40, CD86, FAS, FASLG
15immune responseGO:00069558.6CD40, CD86, FAS, FASLG, TNFSF8

Molecular functions related to Acute Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:000503110.1CD40, FAS
2tumor necrosis factor receptor bindingGO:000516410.0FASLG, TNFSF8
3receptor activityGO:00048729.4CD40, CD86, FAS

Sources for Acute Myocarditis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet