MCID: ACT076
MIFTS: 47

Acute Myocarditis malady

Cardiovascular diseases, Muscle diseases, Rare diseases categories
Download this MalaCard

Summaries for Acute Myocarditis

About this section


Fully expand this MalaCard
MalaCards based summary: Acute Myocarditis is related to myocarditis and acute myocardial infarction. An important gene associated with Acute Myocarditis is TNC (tenascin C), and among its related pathways are FAS (CD95) signaling pathway and African trypanosomiasis. The compounds (glc)4 and procainamide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and liver.

Aliases & Classifications for Acute Myocarditis

About this section
Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 39NCIt, 25ICD10
See all sources

Acute Myocarditis, Aliases & Descriptions:

Name: Acute Myocarditis 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Muscle diseases


External Ids:

Disease Ontology8 DOID:3951
ICD9CM27 422.90, 422
NCIt39 C35206
ICD1025 I40

Related Diseases for Acute Myocarditis

About this section

Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis32.7TXN
2acute myocardial infarction31.0TNC, TXN, ACE
3lupus erythematosus30.9CD70, APOH
4systemic lupus erythematosus30.0FAS, FASLG, CD70, APOH
5hepatitis29.8FASLG, FAS, TXN
6myocardial infarction10.7
7dilated cardiomyopathy10.6
8atrioventricular block10.5
9uveitis10.4ACE
10influenza10.4
11systemic scleroderma10.4ACE
12retinal artery occlusion10.4APOH
13aneurysm10.4
14cardiogenic shock10.4
15pericarditis10.3
16eosinophilia10.3
17malignant mesothelioma10.2TXN, TNC
18hyperhomocysteinemia10.2APOH, TXN
19malaria10.2
20diastolic heart failure10.2
21coronary artery vasospasm10.2
22hypertrophic cardiomyopathy10.2
23acute orbital inflammation10.2
24pneumonia10.2
25pheochromocytoma10.2
26cerebrovascular disease10.1APOH, ACE
27congestive heart failure10.1TXN, ACE
28idiopathic pulmonary fibrosis10.1FASLG, TNC
29keloids10.1FAS, TNC
30nephritis10.1APOH, ACE
31vascular disease10.0ACE, TNC, APOH
32toxic epidermal necrolysis10.0FAS, FASLG
33vogt-koyanagi-harada disease10.0FASLG, FAS
34crohn's disease10.0
35dengue hemorrhagic fever10.0
36hepatitis b10.0
37acute pancreatitis10.0
38cardiac tamponade10.0
39lateral myocardial infarction10.0
40kawasaki disease10.0
41third-degree atrioventricular block10.0
42chikungunya10.0
43japanese spotted fever10.0
44mumps10.0
45chagas disease10.0
46rubella10.0
47fiedler's myocarditis10.0
48neuronitis10.0
49appendicitis10.0
50bullous pemphigoid10.0

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Symptoms for Acute Myocarditis

About this section

Drugs & Therapeutics for Acute Myocarditis

About this section

Drug clinical trials:

Search ClinicalTrials for Acute Myocarditis

Search NIH Clinical Center for Acute Myocarditis

Genetic Tests for Acute Myocarditis

About this section

Anatomical Context for Acute Myocarditis

About this section

MalaCards organs/tissues related to Acute Myocarditis:

32
Heart, T cells, Liver, Cardiac myocytes, Kidney, Myeloid

Animal Models for Acute Myocarditis or affiliated genes

About this section

Publications for Acute Myocarditis

About this section

Articles related to Acute Myocarditis:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Formation of a fibrin net on the polypropylene membrane oxygenator used for percutaneous cardiopulmonary support in a patient with acute myocarditis. (24875892)
2014
2
Acute myocarditis associated with coxsackievirus b4 mimicking influenza myocarditis: electron microscopy detection of causal virus of myocarditis. (24366591)
2013
3
Electrocardiographic findings and myocardial damage in acute myocarditis detected by cardiac magnetic resonance. (22388951)
2012
4
Altered left ventricular tissue velocities, deformation and twist in children and young adults with acute myocarditis and normal ejection fraction. (22101088)
2012
5
Rapidly fatal community-acquired pneumonia due to Klebsiella pneumoniae complicated with acute myocarditis and accelerated idioventricular rhythm. (22153763)
2012
6
A delayed diagnosis of acute myocarditis: diagnostic value of cardiovascular magnetic resonance imaging. (22892447)
2012
7
Churg-Strauss syndrome presenting with acute myocarditis and cardiogenic shock. (21963398)
2012
8
Acute myocarditis mimicking reverse Takotsubo cardiomyopathy. (21242509)
2011
9
In vivo characterization of cytokine profiles and viral load during murine cytomegalovirus-induced acute myocarditis. (19217318)
2010
10
Parvovirus B19 profiles in patients presenting with acute myocarditis and chronic dilated cardiomyopathy. (19043365)
2008
11
Late enhancement detected by cardiac magnetic resonance imaging in acute myocarditis mimicking acute myocardial infarction: location patterns and lack of correlation with systolic function. (18163015)
2007
12
Diagnostic value of ECG-gated multidetector computed tomography in the early phase of suspected acute myocarditis. A preliminary comparative study with cardiac MRI. (16953372)
2007
13
Muronomab-CD3 for pediatric acute myocarditis. (17165111)
2007
14
Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia. (15964086)
2006
15
Immunity status against coxsackie viruses B in 25 patients with acute myocarditis. (18389726)
2006
16
Recovery of acute myocarditis with biventricular assist device in infant. (16274783)
2005
17
Short-term prognostic value of initial serum levels of interleukin-10 in patients with acute myocarditis. (15642541)
2005
18
Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. (15306225)
2004
19
Acute myocarditis associated with adenoviral infection in a patient with scleroderma. (14677036)
2003
20
Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L, CD30L, OX40L and 4-1BBL in the heart of patients with acute myocarditis and dilated cardiomyopathy. (12031769)
2002
21
Acute myocarditis (predominately lymphocytic) causing sudden death without heart failure. (11704019)
2001
22
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
23
Acute myocarditis and left ventricular "hypertrophy". (11000592)
2000
24
Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus. (9529271)
1998
25
Extracorporeal membrane oxygenation in treatment of cardiogenic shock caused by acute myocarditis. (9610063)
1998
26
Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies. (9721703)
1998
27
Expression of cytokine mRNAs in murine hearts with acute myocarditis caused by coxsackievirus b3. (9370955)
1997
28
Images in cardiovascular medicine. Acute myocarditis masquerading as acute myocardial infarction. (7882500)
1995
29
Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. (7635939)
1995
30
Acute myocarditis. Rapid diagnosis by PCR in children. (8026015)
1994
31
Coronary arterial occlusion and myocardial infarction in acute myocarditis. (2303303)
1990
32
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
33
Detection of acute myocarditis using nuclear magnetic resonance imaging. (3400714)
1988
34
Increase in serum free fatty acids, phospholipids and reduction in total cholesterol in acute myocarditis produced by scorpion (Buthus tamulus) venom injection in dogs. (3570321)
1986
35
Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. (3939646)
1985
36
Liver glycogen depletion in acute myocarditis produced by scorpion venom (buthus tamulus). (6724623)
1984
37
Acute myocarditis associated with hepatitis B virus infection--a case report. (6629408)
1983
38
Left atrial myxoma. Clinical presentation suggesting acute myocarditis. (4479150)
1974
39
Acute myocarditis in rats inoculated with Trypanosoma cruzi: study of animals sacrificed between the fourth and twenty-ninth day after infection. (4627073)
1972
40
Coxsackie B5 virus responsible for acute myocarditis inucklings. (5439221)
1970
41
Contribution to the enzymic diagnosis of acute myocarditis, myocardial infarction and cardiogenic shock. (5384064)
1969
42
THE EFFECT OF PHENOBARBITAL ON THE ELECTROCARDIOGRAM IN ACUTE MYOCARDITIS. (14333176)
1965
43
ACUTE MYOCARDITIS IN INFANCY AND CHILDHOOD. (14209575)
1964
44
ACUTE MYOCARDITIS IN THE ADULT. (14214812)
1964
45
Working capacity and heart volume in patients with electrocardiographic abnormalities suggestive of acute myocarditis during various acute infectious diseases. (13508117)
1957
46
ACUTE myocarditis. (13490888)
1957
47
Electrocardiogram of the month: acute myocarditis. (13320513)
1956
48
Transient electrocardiographic changes simulating an acute myocarditis in serum sickness. (13065994)
1953
49
Meningococcemia with acute leptomeningitis and acute myocarditis. (21000434)
1946
50
A CASE OF DIPHTHERIAL ACUTE MYOCARDITIS STUDIED BY MEANS OF THE PORTABLE ELECTRO-CARDIOGRAPH. (20775498)
1930

Variations for Acute Myocarditis

About this section

Expression for genes affiliated with Acute Myocarditis

About this section
Expression patterns in normal tissues for genes affiliated with Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

About this section

Pathways related to Acute Myocarditis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TRAIL signaling pathway37
9.5FAS, FASLG
29.5FASLG, FAS
3
Show member pathways
9.5FASLG, FAS
4
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.5FASLG, FAS
59.5FASLG, FAS
6
Show member pathways
9.5FASLG, FAS
7
Show member pathways
9.1FASLG, FAS, SDHA
8
Show member pathways
9.0CD70, FASLG, FAS
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.0CD70, FASLG, FAS
10
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9FAS, FASLG, ACE
118.7TXN, FAS, FASLG
128.7FASLG, FAS, TXN

Compounds for genes affiliated with Acute Myocarditis

About this section

Compounds related to Acute Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1(glc)4449.9FASLG, FAS
2procainamide44 1110.9APOH, CD70
3teniposide44 1110.9FASLG, FAS
4concanamycin a44 6110.8FAS, FASLG
5p003449.7TNC, APOH, FASLG
6hydralazine44 50 1111.7ACE, CD70
72-chlorodeoxyadenosine449.7FASLG, FAS
8selenodiglutathione449.6TXN, FAS
9tgf beta1449.6FAS, TNC, FASLG
10atpo28 4410.5FASLG, APOH, FAS
11ivig449.5FAS, APOH, FASLG
12ubiquinone449.5TXN, SDHA
13dutp449.5FAS, FASLG
14agarose449.5APOH, FASLG, FAS
15phosphatidylserine44 28 1111.5FAS, FASLG, APOH
16cystine449.4TXN, FASLG
173-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4FAS, FASLG
18ionomycin449.4CD70, FAS, FASLG
19ly294002449.3FASLG, FAS, TNC
20rantes449.3FASLG, FAS, CD70
21aspirin44 50 28 2412.3ACE, APOH, FAS
22wortmannin449.3TNC, FAS, FASLG
23heparin44 28 24 1112.2FASLG, APOH, FAS, TNC
24paraffin449.2TNC, FAS, FASLG
25suberoylanilide hydroxamic acid449.1TXN, FAS, FASLG
26daunorubicin44 50 1111.1FAS, TXN, FASLG
27mitomycin c449.1FAS, FASLG, TXN
28phosphatidylinositol449.1TNC, FAS, FASLG, APOH
29resveratrol44 61 24 1112.1FASLG, TXN, FAS
30adriamycin449.1FASLG, FAS, TXN
31arsenite44 2410.1FASLG, TXN, FAS
32agar449.0FASLG, FAS, TXN
33etoposide44 50 61 1112.0FAS, TXN, FASLG
34n acetylcysteine449.0FAS, TXN, FASLG
35sulforaphane448.8TXN, FAS
36nitric oxide44 24 1110.8ACE, FAS, APOH, FASLG
37ascorbic acid44 249.8FAS, FASLG, TXN, TNC
38glutamate448.8TNC, FASLG, TXN, APOH
39actinomycin d448.8FASLG, TNC, TXN, FAS
40doxorubicin44 50 1110.7TXN, FAS, FASLG
41cycloheximide448.7FASLG, TXN, TNC, FAS
42h2o2448.7FASLG, TNC, TXN, FAS
43estrogen448.7APOH, TXN, FASLG, TNC
44dexamethasone44 50 28 1111.7TNC, TXN, FAS, FASLG
45lactate448.7APOH, TXN, FASLG, FAS
46oxygen44 249.6FAS, APOH, SDHA, TXN
47retinoic acid44 249.6FAS, FASLG, TNC, TXN
48cysteine448.6TNC, FASLG, TXN, FAS
49vegf448.4FAS, FASLG, TNC, TXN, APOH
50creatinine448.2TXN, APOH, TNC, ACE, FAS

GO Terms for genes affiliated with Acute Myocarditis

About this section

Cellular components related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9FAS, ACE, FASLG
2extracellular spaceGO:0056158.0CD70, ACE, FASLG, APOH, TNC
3extracellular vesicular exosomeGO:0700627.2FAS, FASLG, ACE, CD70, TXN

Biological processes related to Acute Myocarditis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.7FASLG, FAS
2necroptotic signaling pathwayGO:0975279.6FASLG, FAS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.6FAS, FASLG
4activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.5FAS, FASLG
5extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.4FAS, FASLG
6negative regulation of angiogenesisGO:0165259.3APOH, FASLG
7extrinsic apoptotic signaling pathwayGO:0971919.2CD70, FASLG, FAS
8cell-cell signalingGO:0072678.7FASLG, TXN, CD70
9signal transductionGO:0071658.2TXN, FAS, FASLG, CD70

Molecular functions related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5CD70, FASLG
2protein bindingGO:0055156.4CD70, ACE, FASLG, FAS, APOH, TXN

Products for genes affiliated with Acute Myocarditis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Acute Myocarditis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet