MCID: ACT076
MIFTS: 49

Acute Myocarditis malady

Cardiovascular diseases category

Summaries for Acute Myocarditis

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32MalaCards
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MalaCards: Acute Myocarditis is related to myocarditis and acute myocardial infarction. An important gene associated with Acute Myocarditis is TNC (tenascin C), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Regulation by c-FLIP. The compounds cycloheximide and ivig have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and tonsil, and related mouse phenotypes are vision/eye and liver/biliary system.

Aliases & Classifications for Acute Myocarditis

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

acute myocarditis 8 44 60


External Ids:

Disease Ontology8 DOID:3951
ICD9CM27 422.90, 422
NCIt39 C35206
ICD1025 I40

Related Diseases for Acute Myocarditis

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17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

acute myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Acute Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis31.9TXN
2acute myocardial infarction30.9ACE, TXN, TNC, FABP3, FGA, ABCB7
3myocardial infarction30.9PROM1, ABCB7, FABP3, TNC, FGA, PLAT
4dilated cardiomyopathy30.7FGA, FABP3, ACE, TXN
5influenza30.4TXN
6lupus erythematosus30.4APOH, CD70
7systemic lupus erythematosus30.4FAS, APOH, FASLG, FGA, CD70
8pneumonia30.3FGA, TXN
9acute pancreatitis29.9ABCB7
10hepatitis b29.9TXN, ABCB7
11hepatitis29.9FASLG, TXN, FAS
12pulmonary embolism29.9FABP3, PLAT, FGA, APOH
13atrioventricular block10.5
14pericarditis10.3
15eosinophilia10.2
16coronary artery vasospasm10.1
17hypertrophic cardiomyopathy10.1
18diastolic heart failure10.1
19acute orbital inflammation10.1
20malaria10.1
21restrictive cardiomyopathy10.1
22pheochromocytoma10.1
23arthritis10.0TXN
24hyperthyroidism10.0SDHA
25thyroiditis10.0FASLG
26dementia10.0FABP3
27cryoglobulinemia10.0APOH
28bronchopulmonary dysplasia10.0TXN
29retinal artery occlusion10.0APOH
30cataract10.0TXN
31connective tissue disease10.0APOH
32lupus nephritis10.0APOH
33retinal vein occlusion10.0APOH
34portal vein thrombosis10.0ABCB7
35migraine10.0APOH
36antithrombin iii deficiency10.0APOH
37primary pulmonary hypertension10.0FGA
38thrombophlebitis10.0APOH
39pancreatic cancer10.0FASLG, TNC
40endometrial carcinoma10.0TNC
41myeloid leukemia10.0FAS
42multiple sclerosis10.0TNC, FASLG
43intermediate coronary syndrome10.0PLAT
44obesity10.0ABCB7, FABP3
45coronary thrombosis10.0PLAT
46astrocytoma10.0TNC, FASLG
47thyroid cancer10.0TNC
48oral cancer10.0TNC, FASLG
49medulloblastoma10.0PROM1
50alzheimer's disease10.0FABP3, TXN

Graphical network of the top 20 diseases related to Acute Myocarditis:



Diseases related to acute myocarditis

Clinical Features for Acute Myocarditis

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Drugs & Therapeutics for Acute Myocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Myocarditis

Drug clinical trials:

Search ClinicalTrials for Acute Myocarditis

Search NIH Clinical Center for Acute Myocarditis

Search CenterWatch for Acute Myocarditis

Genetic Tests for Acute Myocarditis

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Anatomical Context for Acute Myocarditis

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32MalaCards
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MalaCards organs/tissues related to Acute Myocarditis:

32
Heart, T cells, Tonsil, Liver, Cardiac myocytes, Kidney, Pancreas

Animal Models for Acute Myocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Myocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.6PLAT, FABP3
2MP:00053708.1FAS, FASLG, FABP3, FGA, ABCB7, ACE
3MP:00053767.5TNC, APOH, FABP3, FGA, ABCB7, PLAT
4MP:00053857.3ACE, FAS, FASLG, FABP3, PROM1, FGA
5MP:00107686.0TXN, APOH, FAS, FASLG, FABP3, PROM1

Publications for Acute Myocarditis

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50PubMed
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Articles related to Acute Myocarditis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Acute myocarditis in vivax malaria: an extremely rare complication. (23443622)
2013
2
Initial weight and virus dose: two factors affecting the onset of acute coxsackievirus B3 myocarditis in C57BL/6 mouse--a histopathology-based study. (22784985)
2013
3
Percutaneous treatment of a free-floating thrombus in the right atrium of a patient with pulmonary embolism and acute myocarditis. (23076817)
2013
4
Recombinant human coxsackievirus B3 from children with acute myocarditis in China. (23804378)
2013
5
Loeffler myocarditis in pre-B acute lymphoblastic leukaemia with t(5;14)(q31;q32). (22436047)
2012
6
Clinical features and prognosis in Chinese patients with acute fulminant myocarditis. (23252008)
2012
7
Seizures and syncope due to complete atrioventricular block in a patient with acute myocarditis with a normal left ventricular systolic function. (23124146)
2012
8
Cardiogenic shock due to left ventricular outflow obstruction and complete atrioventricular block in a patient with hypertrophic cardiomyopathy with acute myocarditis. (22989828)
2012
9
Streptococcal tonsillitis and acute streptococcal myocarditis: an unusual combination assessed by cardiac magnetic resonance imaging and endomyocardial biopsy. (23012899)
2012
10
Comparison of the clinical presentation, treatment, and outcome of fulminant and acute myocarditis in children. (22307381)
2012
11
Differentiation of acute myocarditis and acute myocardial infarction by the regional distribution of myocardial irreversible injury using cardiovascular magnetic resonance imaging. (22588344)
2012
12
Kawasaki disease complicated with reversible splenial lesion and acute myocarditis. (21380714)
2011
13
A case of acute myocarditis caused by pandemic (H1N1) 2009 influenza virus. (21126658)
2010
14
MR delayed enhancement imaging findings in suspected acute myocarditis. (19657657)
2010
15
Therapy with granulocyte colony-stimulating factor in the chronic stage, but not in the acute stage, improves experimental autoimmune myocarditis in rats via nitric oxide. (20170662)
2010
16
Images in Cardiovascular Medicine. Cardiac magnetic resonance of acute myocarditis in an human immunodeficiency virus patient presenting with acute chest pain syndrome. (20585023)
2010
17
Age and gender effects on the extent of myocardial involvement in acute myocarditis: a cardiovascular magnetic resonance study. (19710029)
2009
18
Combined computed tomography angiography and cardiac magnetic resonance imaging for diagnosis of acute myocarditis in a child with Duchenne myopathy. (19488807)
2009
19
Apoptosis in patients with acute myocarditis. (19766770)
2009
20
Acute myocarditis in a rat model: late gadolinium enhancement with histopathological correlation. (19458951)
2009
21
Acute myocarditis with normal systolic wall thickening: inside physiopathological mechanisms and diagnostic imaging techniques. (17570543)
2008
22
Muronomab-CD3 for pediatric acute myocarditis. (17165111)
2007
23
Third degree atrioventricular block and sudden death secondary to acute myocarditis in a dog. (17689470)
2007
24
Transatrial resection of a left ventricular thrombus after acute myocarditis. (16160906)
2005
25
Diagnostic utility of tenascin-C for evaluation of the activity of human acute myocarditis. (15685595)
2005
26
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
27
Severe transient left ventricular hypertrophy in an infant with acute myocarditis and heart failure. (15185048)
2004
28
Support with the BVS 5000 assist device during treatment of acute giant-cell myocarditis. (12638672)
2003
29
Specific stimulation of peripheral blood mononuclear cells from patients with acute myocarditis by peptide-bound flavin adenine dinucleotide (FAD), a naturally occurring autologous hapten. (12699430)
2003
30
Magnetic resonance imaging in acute myocarditis: a case report and a review of literature. (12365479)
2002
31
Clinicopathological correlates can predict acute myocarditis in patients with recent-onset heart failure: preliminary data. (11974663)
2002
32
Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3. (11955862)
2002
33
Expressional patterns of cytokines in a murine model of acute myocarditis: early expression of cardiotrophin-1. (10744079)
2000
34
Clinical outcomes of acute myocarditis in childhood. (10409542)
1999
35
Expression of cytokine mRNAs in murine hearts with acute myocarditis caused by coxsackievirus b3. (9370955)
1997
36
Temporary mechanical support with the BVS 5000 assist device during treatment of acute myocarditis. (9169372)
1997
37
Colony-stimulating factors and coxackievirus B3 myocarditis in mice: macrophage colony-stimulating factor suppresses acute myocarditis with increasing interferon-alpha. (7484779)
1995
38
Expression of intercellular adhesion molecule-1 in murine hearts with acute myocarditis caused by coxsackievirus B3. (8097205)
1993
39
Brief report: recognition of acute myocarditis masquerading as acute myocardial infarction. (8416421)
1993
40
Acute idiopathic interstitial giant cell myocarditis. A histological and immunohistological study of a case. (1745584)
1991
41
Acute myocarditis simulating myocardial infarction in a child. (1987539)
1991
42
Antimyosin cardiac imaging in acute myocarditis. (2358582)
1990
43
Acute myocarditis in infants. Initial presentation. (2302904)
1990
44
The use of intravenous ribavirin to treat influenza virus-associated acute myocarditis. (2775346)
1989
45
Fulminant acute myocarditis with intractable shock. (3399996)
1988
46
Postpartum cardiomyopathy and acute myocarditis. (4061263)
1985
47
Liver glycogen depletion in acute myocarditis produced by scorpion venom (buthus tamulus). (6724623)
1984
48
The Q-T interval of the electrocardiogram in acute myocarditis in adults, with autopsy correlation. (14799440)
1951
49
Acute non-specific myocarditis in scarlet fever and acute haemolytic tonsillitis A clinical investigation of 3,069 cases of scarlet fever, 798 cases of acute tonsillitis, and 333 cases of haemolytic streptococcus carriers. (14870166)
1951
50
Myocarditis associated with acute nasopharyngitis and acute tonsillitis. (20271991)
1947

Genetic Variations for Acute Myocarditis

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Expression for genes affiliated with Acute Myocarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Myocarditis

Search GEO for disease gene expression data for Acute Myocarditis.

Pathways for genes affiliated with Acute Myocarditis

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Sources:
52R&D Systems, 53Reactome, 12EMD Millipore, 55SinoBiological, 4Cell Signaling Technology
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Compounds for genes affiliated with Acute Myocarditis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acute Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5FASLG
2ivig4410.5APOH
3(glc)44410.1FAS, FASLG
411-dehydrothromboxane b24410.0FGA, APOH
5an 69449.9FGA, ACE
6desirudin449.9FGA, PLAT
7atpo44 2810.8FAS, FASLG, APOH
8fibrinopeptide a449.8FGA, PLAT
9batroxobin449.8FGA, PLAT
10ancrod449.8PLAT, FGA
11palmitate449.8TXN
12delapril449.7ACE, PLAT
13bivalirudin44 1110.7FGA, PLAT
14manidipine449.7PLAT, ACE
15argatroban44 1110.7FGA, PLAT
16selenodiglutathione449.6TXN, FAS
17omapatrilat449.6PLAT, ACE
18glutamate449.6PLAT, ABCB7, APOH
19ticlopidine44 1110.6APOH, FGA, PLAT
20ptca449.6APOH, PLAT, FGA
21thromboxane44 2410.5PLAT, APOH, FGA
22p002449.5FABP3, PLAT, APOH, TNC
23thromboxane a244 2410.4APOH, FGA, PLAT
24enalaprilat449.4PLAT, ACE
25ppack449.4FGA, PLAT
26kininogen449.4ACE, APOH, PLAT
27glucose449.3PLAT, FASLG, APOH, FABP3
28quinapril44 1110.3PLAT, ACE
29suberoylanilide hydroxamic acid449.3FASLG, TXN, FAS
30daunorubicin44 49 1111.2FAS, FASLG, TXN
31p003449.2FABP3, FASLG, APOH, TNC, PLAT
32mitomycin c449.2TXN, FASLG, FAS
33heparin44 28 11 2412.1ABCB7, APOH, FAS, FASLG, FGA
34warfarin44 49 11 2412.1ACE, APOH, FGA, PLAT
35prostacyclin449.0PLAT, ACE, APOH, FGA
36fibrinogen449.0PLAT, TNC, APOH, ABCB7, FGA
37progesterone44 59 28 11 2413.0FASLG, PLAT, ABCB7, TNC, APOH
38paraffin448.9FAS, TNC, FASLG, PLAT
39sodium nitroprusside448.8PLAT, FASLG, FAS
40pge1448.8PLAT, TXN, APOH, FGA
41nitric oxide44 11 2410.7FAS, FASLG, APOH, ACE, ABCB7
42aspirin44 49 28 2411.6ACE, PLAT, APOH, FGA, FAS
43vegf448.6FAS, FASLG, TNC, APOH, TXN
44ascorbic acid44 249.5TXN, TNC, FAS, FASLG, PLAT
45actinomycin d448.4PLAT, FAS, TNC, TXN, FASLG
46lipid448.4TNC, APOH, FABP3, PROM1, FGA, ABCB7
47aspartate448.3PLAT, ABCB7, FASLG, TXN, FAS
48cholesterol44 28 11 2411.2APOH, FGA, ABCB7, PLAT, ACE, FABP3
49lactate448.1FGA, FABP3, ABCB7, TXN, APOH, FASLG
50creatinine447.0APOH, TXN, TNC, FABP3, FGA, ABCB7

GO Terms for genes affiliated with Acute Myocarditis

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16Gene Ontology
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Cellular components related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.3PLAT, APOH, TNC
2external side of plasma membraneGO:0098978.8FAS, FASLG, FGA, ACE
3cell surfaceGO:0099868.4APOH, PROM1, FGA, PLAT
4extracellular regionGO:0055767.0TXN, TNC, FAS, FASLG, FGA, PLAT
5extracellular spaceGO:0056157.0ACE, TNC, TNFSF8, APOH, FASLG, PROM1

Biological processes related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:0069259.8FASLG, FAS
2regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.7FASLG, FAS
3plasminogen activationGO:0316399.4PLAT, APOH
4cellular response to hyperoxiaGO:0714559.2TXN, FAS
5cell-cell signalingGO:0072678.3CD70, FASLG, TNFSF8, TXN
6signal transductionGO:0071657.8FGA, CD70, FASLG, FAS, TNFSF8, TXN

Molecular functions related to Acute Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.4CD70, FASLG, TNFSF8
2cytokine activityGO:0051259.4CD70, FASLG, TNFSF8
3receptor bindingGO:0051028.7TNFSF8, FASLG, CD70, FGA
4protein bindingGO:0055155.5TXN, APOH, FAS, FASLG, FABP3, PROM1

Products for genes affiliated with Acute Myocarditis

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Sources for Acute Myocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet