MCID: ACT064
MIFTS: 29

Acute Necrotizing Encephalitis

Categories: Neuronal diseases

Aliases & Classifications for Acute Necrotizing Encephalitis

MalaCards integrated aliases for Acute Necrotizing Encephalitis:

Name: Acute Necrotizing Encephalitis 12 14
Encephalitis, Acute Necrotizing 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5222
MeSH 41 D004684
NCIt 46 C35383
SNOMED-CT 64 111897007
UMLS 69 C0338418

Summaries for Acute Necrotizing Encephalitis

MalaCards based summary : Acute Necrotizing Encephalitis, also known as encephalitis, acute necrotizing, is related to acute necrotizing encephalopathy and acute necrotizing encephalopathy type 1. An important gene associated with Acute Necrotizing Encephalitis is FOLR1 (Folate Receptor 1), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include temporal lobe and pituitary, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Acute Necrotizing Encephalitis

Diseases related to Acute Necrotizing Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 acute necrotizing encephalopathy 11.2
2 acute necrotizing encephalopathy type 1 11.2
3 encephalitis 10.4
4 polyradiculoneuropathy 10.1 IFNG TBX21
5 erythema multiforme 10.0 GZMB IFNG
6 panniculitis 10.0 GZMB IFNG
7 rasmussen encephalitis 10.0 GZMB IFNG
8 acute graft versus host disease 10.0 GZMB IFNG
9 bronchiolitis obliterans 10.0 GZMB IFNG
10 alopecia areata 9.9 GZMB IFNG
11 graft-versus-host disease 9.9 GZMB IFNG
12 lichen planus 9.9 GZMB IFNG
13 hypersplenism 9.9 FOXP3 IFNG
14 lichen disease 9.9 FOXP3 IFNG
15 autoimmune disease of endocrine system 9.9 FOXP3 IFNG
16 cutaneous t cell lymphoma 9.9 GZMB IFNG
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 FOXP3 IFNG
18 tropical spastic paraparesis 9.8 FOXP3 IFNG
19 conjunctivitis 9.8 FOXP3 IFNG
20 food allergy 9.8 FOXP3 IFNG
21 cutaneous leishmaniasis 9.8 FOXP3 IFNG
22 pancreas adenocarcinoma 9.8 FOXP3 IFNG
23 intestinal disease 9.8 FOXP3 IFNG
24 hypersensitivity reaction disease 9.8 FOXP3 IFNG
25 lymphopenia 9.8 FOXP3 IFNG
26 relapsing-remitting multiple sclerosis 9.7 FOXP3 IFNG
27 hemophagocytic lymphohistiocytosis 9.7 GZMB IFNG
28 immune system disease 9.7 FOXP3 IFNG
29 polycythemia vera 9.7
30 acute chest syndrome 9.7
31 polycythemia 9.7
32 influenza 9.7
33 herpes simplex 9.7
34 sickle cell disease 9.7
35 encephalopathy 9.7
36 visceral leishmaniasis 9.7 FOXP3 IFNG
37 omenn syndrome 9.7 FOXP3 IFNG
38 colitis 9.5 FOXP3 IFNG
39 aplastic anemia 9.5 FOXP3 IFNG TBX21
40 celiac disease 1 9.4 FOXP3 GZMB IFNG
41 common variable immunodeficiency 9.4 FOXP3 IFNG
42 inflammatory bowel disease 9.2 FOXP3 IFNG TBX21

Graphical network of the top 20 diseases related to Acute Necrotizing Encephalitis:



Diseases related to Acute Necrotizing Encephalitis

Symptoms & Phenotypes for Acute Necrotizing Encephalitis

MGI Mouse Phenotypes related to Acute Necrotizing Encephalitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 FOLR1 FOXP3 IFNG TBX21
2 endocrine/exocrine gland MP:0005379 8.92 FOLR1 FOXP3 IFNG TBX21

Drugs & Therapeutics for Acute Necrotizing Encephalitis

Search Clinical Trials , NIH Clinical Center for Acute Necrotizing Encephalitis

Genetic Tests for Acute Necrotizing Encephalitis

Anatomical Context for Acute Necrotizing Encephalitis

MalaCards organs/tissues related to Acute Necrotizing Encephalitis:

38
Temporal Lobe, Pituitary

Publications for Acute Necrotizing Encephalitis

Articles related to Acute Necrotizing Encephalitis:

(show all 24)
# Title Authors Year
1
Acute necrotizing encephalitis associated with cardiovascular manifestations. ( 28681764 )
2017
2
Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review. ( 28852683 )
2017
3
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. ( 12368703 )
2002
4
Acute necrotizing encephalitis. ( 604290 )
1977
5
Acute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettage. Report of two cases. ( 4335254 )
1972
6
Acute necrotizing encephalitis caused by herpes simplex virus. Two cases treated with 5-iodo-2-deoxyuridine. ( 5110953 )
1971
7
Acute necrotizing encephalitis in a patient with Hodgkin's disease. A case report. ( 4334821 )
1971
8
Cerebrospinal fluid in acute necrotizing encephalitis. Hypochlorrhachia as a diagnostic aid. ( 5112210 )
1971
9
The protein composition of the cerebrospinal fluid in acute necrotizing encephalitis. An agar gel electrophoretic and immunoelectrophoretic study. ( 4097238 )
1970
10
The EEG of acute necrotizing encephalitis. ( 4188490 )
1970
11
Clinical problems of acute necrotizing encephalitis. ( 4313666 )
1969
12
Periventricular astrocytosis and acute necrotizing encephalitis. ( 5708550 )
1968
13
Acute necrotizing encephalitis. ( 4295233 )
1968
14
Acute necrotizing encephalitis. Report of a case associated with polycythemia vera. ( 5640195 )
1968
15
Acute necrotizing encephalitis. ( 20329030 )
1967
16
Acute necrotizing encephalitis. ( 4292085 )
1967
17
Acute necrotizing encephalitis: a problem in diagnosis. ( 4291841 )
1967
18
Acute necrotizing encephalitis: observations of herpes-like particles by electron microscopy. ( 4295102 )
1966
19
Atypic acute necrotizing encephalitis. ( 6004659 )
1966
20
An acute necrotizing encephalitis with atypical features. ( 6004660 )
1966
21
RADIOLOGIC FINDINGS IN ACUTE NECROTIZING ENCEPHALITIS. ( 14323906 )
1965
22
ACUTE NECROTIZING ENCEPHALITIS. ( 14158092 )
1964
23
Acute necrotizing encephalitis. A diagnostic problem in temporal lobe disease: report of three cases. ( 13867295 )
1962
24
Acute necrotizing encephalitis. A diagnostic problem in unilateral temporal lobe disease. ( 13867294 )
1961

Variations for Acute Necrotizing Encephalitis

Expression for Acute Necrotizing Encephalitis

Search GEO for disease gene expression data for Acute Necrotizing Encephalitis.

Pathways for Acute Necrotizing Encephalitis

Pathways related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 FOXP3 GZMB IFNG
2
Show member pathways
12.15 FOXP3 IFNG TBX21
3 11.77 FOXP3 GZMB IFNG TBX21
4
Show member pathways
11.55 IFNG TBX21
5
Show member pathways
11.55 GZMB IFNG TBX21
6
Show member pathways
11.48 GZMB IFNG
7 11.42 IFNG TBX21
8 11.34 GZMB IFNG TBX21
9
Show member pathways
11.26 GZMB IFNG
10
Show member pathways
11.21 FOXP3 IFNG TBX21
11 11.12 FOXP3 IFNG
12 10.91 IFNG TBX21
13 10.82 IFNG TBX21
14
Show member pathways
10.36 FOXP3 GZMB IFNG

GO Terms for Acute Necrotizing Encephalitis

Biological processes related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.58 FOXP3 IFNG TBX21
2 negative regulation of transcription, DNA-templated GO:0045892 9.54 FOXP3 IFNG TBX21
3 regulation of regulatory T cell differentiation GO:0045589 9.32 FOXP3 IFNG
4 negative regulation of interleukin-2 production GO:0032703 9.26 FOXP3 TBX21
5 negative regulation of interleukin-17 production GO:0032700 9.16 FOXP3 IFNG
6 response to virus GO:0009615 9.13 FOXP3 IFNG TBX21
7 negative regulation of T-helper 17 cell differentiation GO:2000320 8.62 FOXP3 TBX21

Sources for Acute Necrotizing Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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