MCID: ACT064
MIFTS: 26

Acute Necrotizing Encephalitis

Categories: Neuronal diseases

Aliases & Classifications for Acute Necrotizing Encephalitis

MalaCards integrated aliases for Acute Necrotizing Encephalitis:

Name: Acute Necrotizing Encephalitis 12 14
Encephalitis, Acute Necrotizing 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5222
MeSH 42 D004684
NCIt 47 C35383
SNOMED-CT 64 111897007
UMLS 69 C0338418

Summaries for Acute Necrotizing Encephalitis

MalaCards based summary : Acute Necrotizing Encephalitis, also known as encephalitis, acute necrotizing, is related to acute necrotizing encephalopathy and acute necrotizing encephalopathy type 1. An important gene associated with Acute Necrotizing Encephalitis is FOLR1 (Folate Receptor 1), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include temporal lobe and pituitary, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Acute Necrotizing Encephalitis

Diseases related to Acute Necrotizing Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
id Related Disease Score Top Affiliating Genes
1 acute necrotizing encephalopathy 11.0
2 acute necrotizing encephalopathy type 1 11.0
3 encephalitis 10.3
4 bolivian hemorrhagic fever 10.1 GZMB IFNG
5 mixed cell type cancer 10.1 GZMB IFNG
6 acute monoblastic leukemia 10.1 GZMB IFNG
7 reardon wilson cavanagh syndrome 10.1 GZMB IFNG
8 burn scar 10.0 GZMB IFNG
9 intestinal disaccharidase deficiency 10.0 GZMB IFNG
10 central sleep apnea 10.0 GZMB IFNG
11 childhood brain stem glioma 9.9 FOXP3 IFNG
12 pyridoxine-responsive sideroblastic anemia 9.9 GZMB IFNG
13 combined cellular and humoral immune defects with granulomas 9.9 FOXP3 IFNG
14 cd3zeta deficiency 9.9 FOXP3 IFNG
15 pancreatic somatostatinoma 9.9 FOXP3 IFNG
16 corneal intraepithelial neoplasm 9.8 FOXP3 IFNG
17 balkan nephropathy 9.8 FOXP3 IFNG
18 dengue disease 9.8 FOXP3 IFNG
19 mucocutaneous leishmaniasis 9.8 FOXP3 IFNG
20 endometrial clear cell adenocarcinoma 9.8 FOXP3 IFNG
21 lymphoma 9.8 FOXP3 IFNG
22 hepatitis b 9.8 GZMB IFNG
23 childhood testicular mixed germ cell tumor 9.8 FOXP3 IFNG
24 neonatal jaundice 9.7 FOXP3 IFNG
25 sarcoidosis 1 9.7 GZMB IFNG
26 lacrimal system cancer 9.7 FOXP3 IFNG
27 autoimmune thyroid disease 4 9.7 FOXP3 IFNG
28 acute chest syndrome 9.7
29 polycythemia 9.7
30 influenza 9.7
31 herpes simplex 9.7
32 sickle cell disease 9.7
33 encephalopathy 9.7
34 pseudohypoparathyroidism 9.6 FOXP3 IFNG
35 advanced sleep phase syndrome, familial, 1 9.5 FOXP3 IFNG
36 microscopic colitis 9.4 FOXP3 IFNG
37 hypocalciuric hypercalcemia, type i 9.4 FOXP3 IFNG TBX21
38 congenital symblepharon 9.2 FOXP3 IFNG
39 von economo's disease 8.3 FOLR1 FOXP3 GZMB IFNG TBX21

Graphical network of the top 20 diseases related to Acute Necrotizing Encephalitis:



Diseases related to Acute Necrotizing Encephalitis

Symptoms & Phenotypes for Acute Necrotizing Encephalitis

MGI Mouse Phenotypes related to Acute Necrotizing Encephalitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 FOLR1 FOXP3 IFNG TBX21
2 endocrine/exocrine gland MP:0005379 8.92 IFNG TBX21 FOLR1 FOXP3

Drugs & Therapeutics for Acute Necrotizing Encephalitis

Search Clinical Trials , NIH Clinical Center for Acute Necrotizing Encephalitis

Genetic Tests for Acute Necrotizing Encephalitis

Anatomical Context for Acute Necrotizing Encephalitis

MalaCards organs/tissues related to Acute Necrotizing Encephalitis:

39
Temporal Lobe, Pituitary

Publications for Acute Necrotizing Encephalitis

Articles related to Acute Necrotizing Encephalitis:

(show all 24)
id Title Authors Year
1
Successful Treatment of Influenza-Associated Acute Necrotizing Encephalitis in an Adult Using High-Dose Oseltamivir and Methylprednisolone: Case Report and Literature Review. ( 28852683 )
2017
2
Acute necrotizing encephalitis associated with cardiovascular manifestations. ( 28681764 )
2017
3
Unusual encephalopathy after acute chest syndrome in sickle cell disease: acute necrotizing encephalitis. ( 12368703 )
2002
4
Acute necrotizing encephalitis. ( 604290 )
1977
5
Acute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettage. Report of two cases. ( 4335254 )
1972
6
Acute necrotizing encephalitis in a patient with Hodgkin's disease. A case report. ( 4334821 )
1971
7
Acute necrotizing encephalitis caused by herpes simplex virus. Two cases treated with 5-iodo-2-deoxyuridine. ( 5110953 )
1971
8
Cerebrospinal fluid in acute necrotizing encephalitis. Hypochlorrhachia as a diagnostic aid. ( 5112210 )
1971
9
The EEG of acute necrotizing encephalitis. ( 4188490 )
1970
10
The protein composition of the cerebrospinal fluid in acute necrotizing encephalitis. An agar gel electrophoretic and immunoelectrophoretic study. ( 4097238 )
1970
11
Clinical problems of acute necrotizing encephalitis. ( 4313666 )
1969
12
Acute necrotizing encephalitis. ( 4295233 )
1968
13
Acute necrotizing encephalitis. Report of a case associated with polycythemia vera. ( 5640195 )
1968
14
Periventricular astrocytosis and acute necrotizing encephalitis. ( 5708550 )
1968
15
Acute necrotizing encephalitis. ( 20329030 )
1967
16
Acute necrotizing encephalitis. ( 4292085 )
1967
17
Acute necrotizing encephalitis: a problem in diagnosis. ( 4291841 )
1967
18
An acute necrotizing encephalitis with atypical features. ( 6004660 )
1966
19
Acute necrotizing encephalitis: observations of herpes-like particles by electron microscopy. ( 4295102 )
1966
20
Atypic acute necrotizing encephalitis. ( 6004659 )
1966
21
RADIOLOGIC FINDINGS IN ACUTE NECROTIZING ENCEPHALITIS. ( 14323906 )
1965
22
ACUTE NECROTIZING ENCEPHALITIS. ( 14158092 )
1964
23
Acute necrotizing encephalitis. A diagnostic problem in temporal lobe disease: report of three cases. ( 13867295 )
1962
24
Acute necrotizing encephalitis. A diagnostic problem in unilateral temporal lobe disease. ( 13867294 )
1961

Variations for Acute Necrotizing Encephalitis

Expression for Acute Necrotizing Encephalitis

Search GEO for disease gene expression data for Acute Necrotizing Encephalitis.

Pathways for Acute Necrotizing Encephalitis

Pathways related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 FOXP3 GZMB IFNG
2
Show member pathways
12.15 FOXP3 IFNG TBX21
3 11.75 FOXP3 GZMB IFNG TBX21
4
Show member pathways
11.57 IFNG TBX21
5
Show member pathways
11.55 GZMB IFNG TBX21
6
Show member pathways
11.53 GZMB IFNG
7 11.42 IFNG TBX21
8 11.34 GZMB IFNG TBX21
9
Show member pathways
11.26 GZMB IFNG
10
Show member pathways
11.21 FOXP3 IFNG TBX21
11 11.13 FOXP3 IFNG
12 10.91 IFNG TBX21
13 10.82 IFNG TBX21
14
Show member pathways
10.4 FOXP3 GZMB IFNG

GO Terms for Acute Necrotizing Encephalitis

Biological processes related to Acute Necrotizing Encephalitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.43 FOXP3 IFNG TBX21
2 T cell receptor signaling pathway GO:0050852 9.37 FOXP3 IFNG
3 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.32 FOXP3 IFNG
4 negative regulation of interleukin-17 production GO:0032700 9.16 FOXP3 IFNG
5 positive regulation of isotype switching to IgG isotypes GO:0048304 8.96 IFNG TBX21
6 response to virus GO:0009615 8.8 FOXP3 IFNG TBX21

Sources for Acute Necrotizing Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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