MCID: ACT027
MIFTS: 63

Acute Pancreatitis malady

Genetic diseases, Gastrointestinal diseases, Endocrine diseases, Rare diseases, Bone diseases, Immune diseases categories
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Summaries for Acute Pancreatitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

MalaCards: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to pancreatitis and recurrent acute pancreatitis. An important gene associated with Acute Pancreatitis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways is Peptide ligand-binding receptors. The compounds epft and loxiglumide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Aliases & Classifications for Acute Pancreatitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

acute pancreatitis 8 10 45 62
pancreatitis, acute necrotizing 62
acute necrotizing pancreatitis 8
acute pancreatitis unspecified 8
pancreatitis necrotizing 8
necrotizing pancreatitis 45
acute pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:2913
ICD9CM27 577.0
ICD1025 K85

Related Diseases for Acute Pancreatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hereditary Pancreatitis family:

acute pancreatitis Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.8SST, ELANE, PRSS2, CLPS, SULT1A3, MPO
2recurrent acute pancreatitis31.6SPINK1, CFTR, SCT
3obstructive jaundice30.7CCK, SLC17A5
4cholangitis30.7CFTR, SLC17A5
5cholecystitis30.6CCK
6mediastinitis30.5CRP
7cystic fibrosis30.5SPINK1, CFTR, SCT, MPO, ELANE
8diabetes mellitus30.5SPINK1, SCT, SST, CCK, CRP
9neuroendocrine tumor30.4CCK, SST, SCT
10obesity30.4SLC17A5, CRP, IL18, CCK, CLPS, SULT1A3
11cholelithiasis30.4SST, CCK
12wegener's granulomatosis30.3MPO, ELANE
13parotitis30.3SPINK1
14sepsis30.3MPO, SULT1A3, CXCL5, ELANE, IL18, CRP
15pancreatic cancer30.3CCK, SST, SCT, CFTR, SPINK1
16systemic lupus erythematosus30.2CRP, IL18, SULT1A3, MPO
17type 2 diabetes mellitus30.2SLC17A5, CRP, CCK, SCT, SPINK1
18hepatocellular carcinoma30.2SPINK1, SCT, ELANE, SLC17A5
19ulcerative colitis30.1CFTR, MPO, CXCL5, ELANE, IL18, CRP
20hereditary pancreatitis30.0SPINK1, CFTR
21gallbladder disease30.0CFTR, CCK
22diarrhea30.0CRP, SST, CFTR
23duodenal ulcer30.0CCK, SST, SCT
24peptic ulcer disease30.0SCT, SST, CCK
25portal hypertension30.0SST, SLC17A5
26polyarteritis nodosa30.0MPO
27arthritis30.0MPO, SULT1A3, CXCL5, IL18, CRP
28hepatitis b29.9SULT1A3, SLC17A5
29liver cirrhosis29.9SLC17A5, SST, SCT
30hyperglycemia29.9CRP, CCK, SST, SCT
31gastritis29.9SCT, CXCL5, SST, CCK
32alcoholic pancreatitis29.9SPINK1, CFTR, SCT, ELANE, CCK
33proteinuria29.9CRP, MPO, CFTR
34adult respiratory distress syndrome29.9ELANE, MPO
35nephritis29.8MPO, SULT1A3, IL18
36steatorrhea29.8CFTR, CCK, SST, ELANE, CLPS, SCT
37pneumonia29.8CFTR, MPO, CXCL5, ELANE, CRP
38pancreatitis, chronic29.8SPINK1, CFTR, SCT, CXCL5, ELANE, SST
39inflammatory bowel disease29.7SCT, MPO, CXCL5, ELANE, IL18, CRP
40rheumatoid arthritis29.7CRP, IL18, ELANE, CXCL5, PRSS2, MPO
41hypertriglyceridemia10.7
42duodenitis10.6
43hepatitis10.6
44peritonitis10.4
45endotheliitis10.4
46compartment syndrome10.4
47diabetic ketoacidosis10.3
48thrombotic thrombocytopenic purpura10.3
49hyperparathyroidism10.3
50purpura10.3

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to acute pancreatitis

Symptoms for Acute Pancreatitis

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Drugs & Therapeutics for Acute Pancreatitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Pancreatitis

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

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Anatomical Context for Acute Pancreatitis

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33MalaCards
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MalaCards organs/tissues related to Acute Pancreatitis:

33
Pancreas, Lung, Liver, Monocytes, Testes, Kidney, Endothelial, T cells, Spleen, Myeloid, Breast, Colon, Smooth muscle, Heart, Thyroid, Thymus, Lymph node, Bone, Pancreatic islet

Animal Models for Acute Pancreatitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4SPINK1, CFTR, CLPS, SST, IL18
2MP:00053787.7SLC17A5, GATM, IL18, SST, CLPS, CFTR
3MP:00053867.7CFTR, SCT, CLPS, SST, IL18, GATM
4MP:00053877.5SPINK1, CFTR, MPO, ELANE, SST, IL18
5MP:00053765.6SLC17A5, SPINK1, CFTR, SCT, MPO, CLPS

Publications for Acute Pancreatitis

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52PubMed
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Articles related to Acute Pancreatitis:

(show top 50)    (show all 1378)
idTitleAuthorsYear
1
Plasma copeptin levels are associated with prognosis of severe acute pancreatitis. (24184419)
2014
2
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
3
Early acute pancreatitis in a child with compound heterozygosis a88F508/R1438W/Y1032C cystic fibrosis: a case report. (23883480)
2013
4
Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats. (23959212)
2013
5
Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy. (23468971)
2013
6
Association Analysis of Genetic Variants in the Myosin IXB Gene in Acute Pancreatitis. (24386489)
2013
7
Effects of trimetazidine in acute pancreatitis induced by L-arginine. (23484468)
2013
8
Copeptin is a predictive biomarker of severity in acute pancreatitis. (23332738)
2013
9
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. (23840154)
2013
10
Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog. (23180148)
2013
11
Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. (23075084)
2013
12
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
13
Evaluation of serum TWEAK concentration in patients with acute pancreatitis. (22356682)
2012
14
Intensive insulin therapy in severe acute pancreatitis: a meta-analysis and systematic review. (23441350)
2012
15
Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. (21963611)
2012
16
Mild acute pancreatitis with vildagliptin use. (23565473)
2012
17
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
18
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
19
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
20
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
21
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (20335783)
2010
22
Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis. (20127414)
2010
23
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
24
Thrombotic thrombocytopenic purpura associated with severe acute pancreatitis in a context of decreased ADAMTS13 activity: a case report. (18989146)
2008
25
Early inflammatory response in acute pancreatitis is little affected by body mass index. (17852885)
2007
26
Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study. (17295762)
2007
27
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
28
Structural evaluation of plasma alpha2-macroglobulin in acute pancreatitis. (16232083)
2005
29
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
30
Early jejunal nutrition with combined pre- and probiotics in acute pancreatitis--prospective, randomized, double-blind investigations]. (12764986)
2003
31
Red blood cells deformability and oxidative stress in acute pancreatitis. (12454371)
2002
32
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
33
Interleukin 18 levels reflect the severity of acute pancreatitis. (12889520)
2001
34
Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin. (10547191)
1999
35
Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin receptor antagonists. (10026436)
1999
36
Clinical evaluation of cholecystokinin-A- receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan. (10026438)
1999
37
Serum levels of extracellular matrix in acute pancreatitis. (10626198)
1999
38
Definition of predictors of a complicated course in acute pancreatitis]. (9931653)
1998
39
A prospective study of serum pancreatic elastase-1 in the diagnosis and assessment of acute pancreatitis. (9669641)
1998
40
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
41
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. (9279965)
1997
42
Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. (8813775)
1996
43
What is the best biochemical test to diagnose acute pancreatitis? A prospective clinical study. (8945483)
1996
44
Surgical strategies in acute pancreatitis. (8119641)
1993
45
Informativeness of the methods of early clinical laboratory diagnosis of acute pancreatitis]. (1630081)
1992
46
The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol. (1724678)
1991
47
Granulocyte elastase in assessment of severity of acute pancreatitis. Comparison with acute-phase proteins C-reactive protein, alpha 1-antitrypsin, and protease inhibitor alpha 2-macroglobulin. (1688526)
1990
48
Diagnosis of membrane disorders in acute pancreatitis]. (2329743)
1990
49
Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. (2554845)
1989
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Acute Pancreatitis

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Expression for genes affiliated with Acute Pancreatitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for genes affiliated with Acute Pancreatitis

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Acute Pancreatitis

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45Novoseek, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 3BitterDB
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Compounds related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1epft4510.0CCK, SCT
2loxiglumide459.9SCT, SST, CCK
3gabexate mesilate459.9CRP, ELANE, SST
4oxyntomodulin45 6110.8SST, SCT, CCK
5omeprazole45 51 29 24 1113.6SST, CCK, CRP, SCT
6taurodeoxycholate459.6CCK, SST, SCT, CLPS
7lactulose459.6SLC17A5, CRP, CCK
8nitroglycerin45 1110.5ELANE, SST, CRP
9ibmx45 61 2911.5SCT, CFTR, SST, CCK
10caffeine45 29 3 51 24 1114.5CFTR, ELANE, SST, CCK
11carbachol45 29 1111.5CCK, CFTR, SCT, SST
121-hydroxyphenazine459.5ELANE, MPO
13ranitidine45 29 24 1112.4IL18, SCT, CCK
14thyroxine45 2410.3SCT, ELANE, SST, SLC17A5
15taurocholate459.3SCT, CFTR, CCK
16trypsinogen459.2SCT, SPINK1, CFTR, PRSS2, ELANE, CCK
17isoproterenol45 1110.2IL18, SST, ELANE, CFTR, SCT
18propylthiouracil45 3 1111.2SLC17A5, ELANE, MPO
19nafamostat mesilate459.1MPO, IL18, ELANE
20cerulein459.1ELANE, CCK, MPO, SCT
21c-peptide459.1SCT, SST, CCK, CRP, SLC17A5
22neopterin459.1ELANE, IL18, CRP, SLC17A5
23dopamine45 29 24 1112.0CCK, CFTR, SCT, SULT1A3, SST
24octreotide45 61 29 1111.8CCK, ELANE, MPO, SCT, SST
25adenylate458.7CCK, SST, ELANE, SCT, CFTR, IL18
26fibrinogen458.7SLC17A5, CRP, SULT1A3, ELANE, IL18
27aspirin45 51 29 2411.7IL18, CCK, ELANE, SULT1A3, CFTR, CRP
28endotoxin458.6CRP, IL18, ELANE, SLC17A5, CXCL5
29cyclosporin a45 29 6110.5SCT, SLC17A5, IL18, ELANE, CFTR, CCK
30folate458.5IL18, CRP, SLC17A5, CCK
31cyclophosphamide45 51 1110.5SST, IL18, MPO, CRP
32prednisolone45 29 1110.5MPO, IL18, SLC17A5, CRP
33dexamethasone45 51 29 1111.5CFTR, SULT1A3, CXCL5, IL18, CCK, SST
34histamine45 29 2410.4IL18, CCK, SCT, MPO, SST
35arginine458.3SULT1A3, SCT, GATM, IL18, SST, CCK
36n acetylcysteine458.3MPO, CFTR, IL18, CRP, SLC17A5
37glutamate458.2IL18, CCK, SST, ELANE, SCT, CFTR
38glutamine458.2IL18, SLC17A5, CFTR, ELANE, CCK, SCT
39cholesterol45 29 24 1111.2IL18, SULT1A3, CLPS, CRP, CCK, SLC17A5
40lactate458.0SLC17A5, SST, CRP, IL18, ELANE, MPO
41testosterone45 61 24 1110.9IL18, CCK, SST, CFTR, SCT, ELANE
42epinephrine45 24 119.9CXCL5, SLC17A5, SST, SCT, CFTR, SULT1A3
43retinoic acid45 248.9IL18, CCK, SST, MPO, SCT, CFTR
44aspartate457.7SLC17A5, GATM, CRP, SULT1A3, IL18, SCT
45acetylcholine45 51 29 24 1111.7ELANE, CFTR, IL18, CCK, SST, MPO
46norepinephrine45 24 119.6IL18, ELANE, CRP, SLC17A5, SULT1A3, CCK
47pge2457.5ELANE, CCK, CXCL5, MPO, SCT, CFTR
48creatinine457.5SULT1A3, MPO, SPINK1, SLC17A5, GATM, IL18
49nitric oxide45 24 119.4CXCL5, SULT1A3, MPO, GATM, SLC17A5, IL18
50calcium45 51 24 1110.0SCT, SPINK1, CRP, CLPS, PRSS2, IL18

GO Terms for genes affiliated with Acute Pancreatitis

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16Gene Ontology
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Cellular components related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3PRSS2, CXCL5, SST, CCK, IL18, CRP
2extracellular regionGO:0055766.6CRP, SPINK1, SCT, CLPS, PRSS2, CXCL5

Biological processes related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to yeastGO:0018789.3ELANE, MPO
2cell-cell signalingGO:0072679.1IL18, SST, CXCL5
3negative regulation of growth of symbiont in hostGO:0441309.1ELANE, MPO

Molecular functions related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5CCK, SST, SCT

Products for genes affiliated with Acute Pancreatitis

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Sources for Acute Pancreatitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet