MCID: ACT027
MIFTS: 64

Acute Pancreatitis malady

Genetic diseases, Gastrointestinal diseases, Endocrine diseases, Rare diseases, Bone diseases, Immune diseases categories
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Summaries for Acute Pancreatitis

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Wikipedia:65 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

MalaCards based summary: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to recurrent acute pancreatitis and cholecystitis. An important gene associated with Acute Pancreatitis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways is Peptide ligand-binding receptors. The compounds epft and loxiglumide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Aliases & Classifications for Acute Pancreatitis

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Acute Pancreatitis, Aliases & Descriptions:

Name: Acute Pancreatitis 8 10 44 62
Pancreatitis, Acute Necrotizing 62
Acute Necrotizing Pancreatitis 8
Acute Pancreatitis Unspecified 8
 
Pancreatitis Necrotizing 8
Necrotizing Pancreatitis 44
Acute Pancreatitis Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:2913
ICD9CM27 577.0
ICD1025 K85

Related Diseases for Acute Pancreatitis

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Diseases in the Hereditary Pancreatitis family:

acute pancreatitis Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Pancreatitis, Chronic
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 342)
idRelated DiseaseScoreTop Affiliating Genes
1recurrent acute pancreatitis32.1SPINK1, CFTR, SCT
2cholecystitis31.2CCK
3mediastinitis31.1CRP
4parotitis31.1SPINK1
5obstructive jaundice31.1CCK, SLC17A5
6cholangitis31.0CFTR, SLC17A5
7cholelithiasis30.8SST, CCK
8neuroendocrine tumor30.7CCK, SST, SCT
9hereditary pancreatitis30.6SPINK1, CFTR
10wegener's granulomatosis30.5MPO, ELANE
11diabetes mellitus30.5SPINK1, SCT, SST, CCK, CRP
12gallbladder disease30.5CFTR, CCK
13pancreatitis30.5SST, ELANE, PRSS2, CLPS, SULT1A3, MPO
14cystic fibrosis30.4SPINK1, CFTR, SCT, MPO, ELANE
15pancreatic cancer30.3CCK, SST, SCT, CFTR, SPINK1
16diarrhea30.3CRP, SST, CFTR
17duodenal ulcer30.3CCK, SST, SCT
18peptic ulcer disease30.3SCT, SST, CCK
19portal hypertension30.3SST, SLC17A5
20polyarteritis nodosa30.3MPO
21hepatitis b30.2SULT1A3, SLC17A5
22proteinuria30.2CRP, MPO, CFTR
23type 2 diabetes mellitus30.1SLC17A5, CRP, CCK, SCT, SPINK1
24liver cirrhosis30.1SLC17A5, SST, SCT
25hyperglycemia30.1CRP, CCK, SST, SCT
26gastritis30.0SCT, CXCL5, SST, CCK
27alcoholic pancreatitis30.0SPINK1, CFTR, SCT, ELANE, CCK
28obesity30.0SLC17A5, CRP, IL18, CCK, CLPS, SULT1A3
29adult respiratory distress syndrome29.9ELANE, MPO
30systemic lupus erythematosus29.9CRP, IL18, SULT1A3, MPO
31nephritis29.8MPO, SULT1A3, IL18
32steatorrhea29.7CFTR, CCK, SST, ELANE, CLPS, SCT
33sepsis29.7MPO, SULT1A3, CXCL5, ELANE, IL18, CRP
34pneumonia29.5CFTR, MPO, CXCL5, ELANE, CRP
35pancreatitis, chronic29.5SPINK1, CFTR, SCT, CXCL5, ELANE, SST
36ulcerative colitis29.5CFTR, MPO, CXCL5, ELANE, IL18, CRP
37arthritis29.5MPO, SULT1A3, CXCL5, IL18, CRP
38inflammatory bowel disease29.1SCT, MPO, CXCL5, ELANE, IL18, CRP
39rheumatoid arthritis29.0CRP, IL18, ELANE, CXCL5, PRSS2, MPO
40hypertriglyceridemia10.7
41duodenitis10.6
42hepatitis10.6
43tropical calcific pancreatitis10.6SPINK1
44angiodysplasia10.5SST
45dumping syndrome10.5SST
46adult-onset still's disease10.5CRP
47aspergillosis10.5ELANE
48duodenogastric reflux10.5CCK
49emphysema due to aat deficiency10.5ELANE
50scrub typhus10.5SLC17A5

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to acute pancreatitis

Symptoms for Acute Pancreatitis

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Drugs & Therapeutics for Acute Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Acute Pancreatitis

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

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Anatomical Context for Acute Pancreatitis

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MalaCards organs/tissues related to Acute Pancreatitis:

32
Pancreas, Lung, Liver, Neutrophil, Monocytes, Testes, Kidney, Endothelial, Spleen, T cells, Heart, Smooth muscle, Colon, Breast, Myeloid, Bone, Lymph node, Thymus, Thyroid, B cells, Pancreatic islet, Pituitary

Animal Models for Acute Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4SPINK1, CFTR, CLPS, SST, IL18
2MP:00053787.7SLC17A5, GATM, IL18, SST, CLPS, CFTR
3MP:00053867.7CFTR, SCT, CLPS, SST, IL18, GATM
4MP:00053877.5SPINK1, CFTR, MPO, ELANE, SST, IL18
5MP:00053765.6SLC17A5, SPINK1, CFTR, SCT, MPO, CLPS

Publications for Acute Pancreatitis

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Articles related to Acute Pancreatitis:

(show top 50)    (show all 1424)
idTitleAuthorsYear
1
A case of recurrent acute pancreatitis due to intra-articular corticosteroid injection. (24618449)
2014
2
Plasma copeptin levels are associated with prognosis of severe acute pancreatitis. (24184419)
2014
3
Acute pancreatitis: a rare complication in a patient with senior loken syndrome. (24702534)
2014
4
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
5
Early acute pancreatitis in a child with compound heterozygosis a88F508/R1438W/Y1032C cystic fibrosis: a case report. (23883480)
2013
6
Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats. (23959212)
2013
7
Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy. (23468971)
2013
8
Association Analysis of Genetic Variants in the Myosin IXB Gene in Acute Pancreatitis. (24386489)
2013
9
Effects of trimetazidine in acute pancreatitis induced by L-arginine. (23484468)
2013
10
Copeptin is a predictive biomarker of severity in acute pancreatitis. (23332738)
2013
11
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. (23840154)
2013
12
Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog. (23180148)
2013
13
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
14
Evaluation of serum TWEAK concentration in patients with acute pancreatitis. (22356682)
2012
15
Intensive insulin therapy in severe acute pancreatitis: a meta-analysis and systematic review. (23441350)
2012
16
Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. (21963611)
2012
17
Mild acute pancreatitis with vildagliptin use. (23565473)
2012
18
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
19
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
20
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
21
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
22
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (20335783)
2010
23
Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis. (20127414)
2010
24
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
25
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
26
Thrombotic thrombocytopenic purpura associated with severe acute pancreatitis in a context of decreased ADAMTS13 activity: a case report. (18989146)
2008
27
Early inflammatory response in acute pancreatitis is little affected by body mass index. (17852885)
2007
28
Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study. (17295762)
2007
29
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
30
Structural evaluation of plasma alpha2-macroglobulin in acute pancreatitis. (16232083)
2005
31
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
32
Early jejunal nutrition with combined pre- and probiotics in acute pancreatitis--prospective, randomized, double-blind investigations]. (12764986)
2003
33
Red blood cells deformability and oxidative stress in acute pancreatitis. (12454371)
2002
34
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
35
Interleukin 18 levels reflect the severity of acute pancreatitis. (12889520)
2001
36
Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin. (10547191)
1999
37
Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin receptor antagonists. (10026436)
1999
38
Clinical evaluation of cholecystokinin-A- receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan. (10026438)
1999
39
Serum levels of extracellular matrix in acute pancreatitis. (10626198)
1999
40
Definition of predictors of a complicated course in acute pancreatitis]. (9931653)
1998
41
A prospective study of serum pancreatic elastase-1 in the diagnosis and assessment of acute pancreatitis. (9669641)
1998
42
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
43
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. (9279965)
1997
44
Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. (8813775)
1996
45
What is the best biochemical test to diagnose acute pancreatitis? A prospective clinical study. (8945483)
1996
46
Surgical strategies in acute pancreatitis. (8119641)
1993
47
Informativeness of the methods of early clinical laboratory diagnosis of acute pancreatitis]. (1630081)
1992
48
The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol. (1724678)
1991
49
Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. (2554845)
1989
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Acute Pancreatitis

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Expression for genes affiliated with Acute Pancreatitis

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Expression patterns in normal tissues for genes affiliated with Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for genes affiliated with Acute Pancreatitis

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Compounds for genes affiliated with Acute Pancreatitis

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Compounds related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1epft4410.0CCK, SCT
2loxiglumide449.9SCT, SST, CCK
3gabexate mesilate449.9CRP, ELANE, SST
4oxyntomodulin44 6110.8SST, SCT, CCK
5omeprazole44 50 28 24 1113.6SST, CCK, CRP, SCT
6taurodeoxycholate449.6CCK, SST, SCT, CLPS
7lactulose449.6SLC17A5, CRP, CCK
8nitroglycerin44 1110.5ELANE, SST, CRP
9ibmx44 61 2811.5SCT, CFTR, SST, CCK
10caffeine44 28 2 50 24 1114.5CFTR, ELANE, SST, CCK
11carbachol44 28 1111.5CCK, CFTR, SCT, SST
121-hydroxyphenazine449.5ELANE, MPO
13ranitidine44 28 24 1112.4IL18, SCT, CCK
14thyroxine44 2410.3SCT, ELANE, SST, SLC17A5
15taurocholate449.3SCT, CFTR, CCK
16trypsinogen449.2SCT, SPINK1, CFTR, PRSS2, ELANE, CCK
17isoproterenol44 1110.2IL18, SST, ELANE, CFTR, SCT
18propylthiouracil44 2 1111.2SLC17A5, ELANE, MPO
19nafamostat mesilate449.1MPO, IL18, ELANE
20cerulein449.1ELANE, CCK, MPO, SCT
21c-peptide449.1SCT, SST, CCK, CRP, SLC17A5
22neopterin449.1ELANE, IL18, CRP, SLC17A5
23dopamine44 28 24 1112.0CCK, CFTR, SCT, SULT1A3, SST
24octreotide44 61 28 1111.8CCK, ELANE, MPO, SCT, SST
25adenylate448.7CCK, SST, ELANE, SCT, CFTR, IL18
26fibrinogen448.7SLC17A5, CRP, SULT1A3, ELANE, IL18
27aspirin44 50 28 2411.7IL18, CCK, ELANE, SULT1A3, CFTR, CRP
28endotoxin448.6CRP, IL18, ELANE, SLC17A5, CXCL5
29cyclosporin a44 28 6110.5SCT, SLC17A5, IL18, ELANE, CFTR, CCK
30folate448.5IL18, CRP, SLC17A5, CCK
31cyclophosphamide44 50 1110.5SST, IL18, MPO, CRP
32prednisolone44 28 1110.5MPO, IL18, SLC17A5, CRP
33dexamethasone44 50 28 1111.5CFTR, SULT1A3, CXCL5, IL18, CCK, SST
34histamine44 28 2410.4IL18, CCK, SCT, MPO, SST
35arginine448.3SULT1A3, SCT, GATM, IL18, SST, CCK
36n acetylcysteine448.3MPO, CFTR, IL18, CRP, SLC17A5
37glutamate448.2IL18, CCK, SST, ELANE, SCT, CFTR
38glutamine448.2IL18, SLC17A5, CFTR, ELANE, CCK, SCT
39cholesterol44 28 24 1111.2IL18, SULT1A3, CLPS, CRP, CCK, SLC17A5
40lactate448.0SLC17A5, SST, CRP, IL18, ELANE, MPO
41testosterone44 61 24 1110.9IL18, CCK, SST, CFTR, SCT, ELANE
42epinephrine44 24 119.9CXCL5, SLC17A5, SST, SCT, CFTR, SULT1A3
43retinoic acid44 248.9IL18, CCK, SST, MPO, SCT, CFTR
44aspartate447.7SLC17A5, GATM, CRP, SULT1A3, IL18, SCT
45acetylcholine44 50 28 24 1111.7ELANE, CFTR, IL18, CCK, SST, MPO
46norepinephrine44 24 119.6IL18, ELANE, CRP, SLC17A5, SULT1A3, CCK
47pge2447.5ELANE, CCK, CXCL5, MPO, SCT, CFTR
48creatinine447.5SULT1A3, MPO, SPINK1, SLC17A5, GATM, IL18
49nitric oxide44 24 119.4CXCL5, SULT1A3, MPO, GATM, SLC17A5, IL18
50calcium44 50 24 1110.0SCT, SPINK1, CRP, CLPS, PRSS2, IL18

GO Terms for genes affiliated with Acute Pancreatitis

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Cellular components related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3PRSS2, CXCL5, SST, CCK, IL18, CRP
2extracellular regionGO:0055766.6CRP, SPINK1, SCT, CLPS, PRSS2, CXCL5

Biological processes related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to yeastGO:0018789.3ELANE, MPO
2cell-cell signalingGO:0072679.1IL18, SST, CXCL5
3negative regulation of growth of symbiont in hostGO:0441309.1ELANE, MPO

Molecular functions related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5CCK, SST, SCT

Products for genes affiliated with Acute Pancreatitis

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Sources for Acute Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet