MCID: ACT027
MIFTS: 63

Acute Pancreatitis malady

Gastrointestinal diseases, Endocrine diseases categories

Summaries for Acute Pancreatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

MalaCards: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to pancreatitis and hepatitis. An important gene associated with Acute Pancreatitis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways are Transcriptional misregulation in cancer and Pancreatic secretion. The compounds lipid and testosterone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Acute Pancreatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

acute pancreatitis 8 10 44 60
pancreatitis, acute necrotizing 60
acute necrotizing pancreatitis 8
acute pancreatitis unspecified 8
pancreatitis necrotizing 8
necrotizing pancreatitis 44
acute pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:2913
ICD9CM27 577.0
ICD1025 K85

Related Diseases for Acute Pancreatitis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pancreatitis, Chronic family:

acute pancreatitis Pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 386)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.2ELANE, CPB1, SPINK1, SULT1A3, CFTR, PLA2G1B
2hepatitis30.8IL18
3recurrent acute pancreatitis30.7SPINK1, CFTR, SCT
4alcoholic pancreatitis30.6CFTR, SPINK1, CPB1, ELANE, CCK, SCT
5peritonitis30.5IL6, CRP, MPO
6pancreatic cancer30.5SCT, SPINK1, SST, CCK
7cystic fibrosis30.5IL8, CFTR, SPINK1, ELANE, REG3A, MPO
8obesity30.5CRP, RETN, CLPS, IL18, CCK, SULT1A3
9cholangitis30.5CFTR
10hyperparathyroidism30.4SCT
11diabetes mellitus30.4SPINK1, IL6, RETN, SST, CRP, SCT
12adenoma30.4SCT, SST, SPINK1
13hypertension30.4RETN, CRP
14cholecystitis30.4CCK
15acute myocardial infarction30.3CRP, RETN, SULT1A3
16myocardial infarction30.3CRP, RETN, SULT1A3
17hypercalcemia30.3SCT, SPINK1
18neuroendocrine tumor30.3SST, SCT, CCK
19acute leukemia30.3MPO, RETN
20leukemia30.3IL6, MPO, CFTR
21systemic lupus erythematosus30.3CRP, IL6, IL18, MPO, SULT1A3
22ischemia30.3PLA2G1B, MPO
23ulcerative colitis30.3CRP
24lupus erythematosus30.3IL18
25mediastinitis30.3CRP
26type 2 diabetes mellitus30.2APOC2, IL6, RETN, SPINK1, CRP, SCT
27hepatocellular carcinoma30.2ELANE, IL6, SPINK1, REG3A, SCT
28wegener's granulomatosis30.2ELANE, MPO
29disseminated intravascular coagulation30.2ELANE
30neutropenia30.1MPO, ELANE
31prostate cancer30.1SPINK1, IL6
32arthritis30.0PLA2G1B, SULT1A3, IL8, MPO, IL6, CRP
33liver cirrhosis30.0SCT, RETN
34glomerulonephritis30.0ELANE, MPO
35graves' disease30.0MPO
36rheumatoid arthritis29.8IL18, IL8, IL6, RETN, PRSS2, MPO
37inflammatory bowel disease29.8CRP, SCT, MPO, REG3A, RETN, IL18
38pancreas disease29.8CCK, SPINK1, ELANE, CFTR, CLPS, REG3A
39pneumonia29.8CRP, IL8, IL6, MPO, ELANE, CFTR
40steatorrhea29.8CCK, SST, CLPS, CFTR, SCT, ELANE
41hyperglycemia29.8SST, CRP, SCT, CCK, RETN
42duodenal ulcer29.8CCK, SCT, SST, IL8
43peptic ulcer29.8CCK, SST, SCT, IL8
44colorectal cancer29.8CCK, SPINK1, REG3A, PRSS2
45adult respiratory distress syndrome29.8IL6, MPO, ELANE, IL8
46gastritis29.8CCK, SCT, IL8, SST
47diarrhea29.8CRP, SST, CFTR
48acromegaly29.8CCK, SST, RETN
49proteinuria29.8CFTR, MPO, CRP, APOC2
50breast cancer29.8SULT1A3, CFTR

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to acute pancreatitis

Clinical Features for Acute Pancreatitis

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Drugs & Therapeutics for Acute Pancreatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Acute Pancreatitis

Search NIH Clinical Center for Acute Pancreatitis

Search CenterWatch for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

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Anatomical Context for Acute Pancreatitis

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32MalaCards
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MalaCards organs/tissues related to Acute Pancreatitis:

32
Pancreas, Lung, Liver, Testes, Monocytes, Kidney, Endothelial, T cells, Myeloid, Spleen, Colon, Pancreatic islet, B cells, Breast, Bone, Smooth muscle, Heart, Pituitary, Prostate, Skin, Salivary gland, Thyroid, Thymus, Lymph node, Bone marrow

Animal Models for Acute Pancreatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3CCK, SPINK1, CFTR, PLA2G1B, IL6, IL18
2MP:000538711.1ELANE, SPINK1, CFTR, IL6, IL8, IL18
3MP:000538110.5SPINK1, CFTR, PLA2G1B, IL6, CLPS

Publications for Acute Pancreatitis

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Sources:
50PubMed
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Articles related to Acute Pancreatitis:

(show top 50)    (show all 1654)
idTitleAuthorsYear
1
Correlation of fibrinogen-like protein 2 with disease progression in patients with severe acute pancreatitis. (24348769)
2014
2
Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis. (23605470)
2013
3
Early goal-directed fluid therapy with fresh frozen plasma reduces severe acute pancreatitis mortality in the intensive care unit. (23673124)
2013
4
Gestational hyperlipidemia and acute pancreatitis with underlying partial lipoprotein lipase deficiency and apolipoprotein E3/E2 genotype. (24009459)
2013
5
Resveratrol suppresses microcirculatory disturbance in a rat model of severe acute pancreatitis. (23546938)
2013
6
Fluid therapy in acute pancreatitis: anybody's guess. (23207241)
2013
7
BML-111, a lipoxin receptor agonist, ameliorates 'two-hit'-induced acute pancreatitis-associated lung injury in mice by the upregulation of heme oxygenase-1. (23802775)
2013
8
Implications of culture positivity in acute pancreatitis: does the source matter? (23425090)
2013
9
Correlation of fibrinogen-like protein 2 with progression of acute pancreatitis in rats. (23674850)
2013
10
Acute Relapsing Pancreatitis with Pseudocyst Formation due to Sporadic Hypertriglyceridemic Pancreatitis: A Case Report. (24426610)
2013
11
Mild acute pancreatitis with vildagliptin use. (23565473)
2012
12
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
13
Severe acute pancreatitis: results of treatment. (23174789)
2012
14
The clinical course of acute pancreatitis and the inflammatory mediators that drive it. (23304633)
2012
15
Acute pancreatitis: the onset digestive manifestation, in a patient with adult T-cell leukemia/lymphoma. (23188452)
2012
16
Plasmapheresis as a therapeutic approach for hypertriglyceridemia-induced acute pancreatitis. (23917833)
2012
17
Comparison of serum procalcitonin with Ranson, APACHE-II, Glasgow and Balthazar CT severity index scores in predicting severity of acute pancreatitis. (21778801)
2011
18
Development of disseminated superficial porokeratosis in a patient with complicated acute pancreatitis. (21426871)
2011
19
High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. (21415673)
2011
20
An uncommon cause of acute pancreatitis. Hereditary angioedema-induced acute pancreatitis. (21110969)
2011
21
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
22
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (20335783)
2010
23
Interventional and surgical management of abdominal compartment syndrome in severe acute pancreatitis. (20571292)
2010
24
Different profiles of cytokine expression during mild and severe acute pancreatitis. (20397261)
2010
25
Membrane proteome analysis of cerulein-stimulated pancreatic acinar cells: implication for early event of acute pancreatitis. (20479917)
2010
26
Value of initial radiological investigations in patients admitted to hospital with appendicitis, acute gallbladder disease or acute pancreatitis. (20511636)
2010
27
Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis. (19534808)
2009
28
Fulminant acute pancreatitis in a patient with familial mediterranean fever on CAPD: what caused the pancreatitis? (19910573)
2009
29
A case of acute pancreatitis and splenic infarction associated with antiphospholipid syndrome]. (19158473)
2009
30
Is there correlation between pancreatic enzyme and radiological severity in acute pancreatitis? (18416469)
2008
31
Mild acute biliary pancreatitis vs cholelithiasis: are there differences in the rate of choledocholithiasis? (17458591)
2007
32
Applicability of disseminated intravascular coagulation parameters in the assessment of the severity of acute pancreatitis. (16340749)
2006
33
Leptin and adiponectin levels in acute pancreatitis. (16552343)
2006
34
Hemobilia in a patient with protein S deficiency after laparoscopic cholecystectomy that caused acute pancreatitis: successful endoscopic management. (15990843)
2005
35
Neurogenic inflammation in acute pancreatitis. (16186661)
2005
36
New aspects of pharmaco-therapy for acute pancreatitis]. (15552891)
2004
37
Increased expression of 19-kD interacting protein-3-like protein and the relationship to apoptosis in the lung of rats with severe acute pancreatitis. (14530762)
2003
38
Aetiologies of recurrent acute pancreatitis: acute or chronic relapsing disease? (11880695)
2001
39
Cost effectiveness study on the use of somatostatin for reduction of acute pancreatitis after ERCP]. (11459565)
2001
40
Acute pancreatitis: a newly recognised potential complication of canine babesiosis. (11212934)
2000
41
Prevention of hyperlipidemic acute pancreatitis during pregnancy with medium-chain triglyceride nutritional support. (9629518)
1998
42
A scoring system for early differentiation of the etiology of acute pancreatitis. (9517534)
1998
43
Postoperative acute pulmonary thromboembolism in patients with acute necrotizing pancreatitis with special reference to apheresis therapy. (10227770)
1998
44
Etiology and pathogenesis of acute pancreatitis]. (9721465)
1998
45
Total splenic infarction in acute pancreatitis. (8930045)
1996
46
Recurrent panniculitis as the first clinical manifestation of recurrent acute pancreatitis secondary to cholelithiasis. (8683492)
1996
47
A bradykinin antagonist inhibited nitric oxide generation and thromboxane biosynthesis in acute pancreatitis. (7659783)
1995
48
The mechanism of action of selenium substitution in inflammatory diseases. Modification of the activity of antioxidative enzymes in patients with acute pancreatitis]. (8385382)
1993
49
Acute pancreatic necrosis in chronic alcoholic pancreatitis. (6745031)
1984
50
Acute suppurative cholangitis secondary to calcific pancreatitis. (964577)
1976

Genetic Variations for Acute Pancreatitis

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Expression for genes affiliated with Acute Pancreatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for genes affiliated with Acute Pancreatitis

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN
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Pathways related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7ELANE, IL6, IL8, MPO
210.7CPB1, CFTR, PLA2G1B, PRSS2
310.7IL6, MPO, CRP
410.7MPO, IL6, ELANE
5
Cytokine production by Th17 cells in CF (Mouse model)
10.7IL8, IL6, CFTR
6
Immune response Bacterial infections in normal airways
10.7CFTR, IL6, IL8
7
Hide members
10.7IL6, IL8, IL18
810.7IL6, IL8, IL18
910.7IL18, IL8, IL6
1010.5IL18
1110.5IL18
1210.5IL8

Compounds for genes affiliated with Acute Pancreatitis

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1lipid4411.5IL18, RETN, IL6, GP2, PLA2G1B, SULT1A3
2testosterone44 59 11 2414.5CCK, SCT, CRP, RETN, IL18, CFTR
3acetylcholine44 49 28 11 2415.4MPO, ELANE, CRP, CCK, SCT, SST
4retinoic acid44 2412.4SCT, CFTR, ELANE, IL6, IL18, MPO
5lactate4411.4ELANE, IL6, IL18, SST, MPO, CRP
6creatinine4411.4MPO, APOC2, CRP, SPINK1, SULT1A3, IL6
7trypsinogen4411.4CFTR, ELANE, SPINK1, REG3A, PRSS2, SCT
8cholesterol44 28 11 2414.4CLPS, CCK, APOC2, CRP, RETN, IL6
9epinephrine44 11 2413.4ELANE, SCT, SST, SULT1A3, CFTR, IL18
10histamine44 28 2413.3CCK, MPO, SST, IL18, IL8, IL6
11dexamethasone44 49 28 1114.3CFTR, RETN, IL6, PLA2G1B, CCK, SULT1A3
12isoproterenol44 1112.3ELANE, SST, SCT, RETN, IL18, CFTR
13aspirin44 49 28 2414.3ELANE, CCK, CRP, IL18, CFTR, SULT1A3
14norepinephrine44 11 2413.3CCK, RETN, CFTR, SULT1A3, ELANE
15cerulein4411.3ELANE, IL6, SCT, CCK, MPO
168-isoprostane4411.2CRP, MPO, RETN, IL8, IL6
17c-peptide4411.2SST, RETN, SCT, CRP, CCK
18neopterin4411.2IL18, IL8, IL6, ELANE, CRP
19n acetylcysteine4411.2CRP, MPO, IL6, CFTR, IL18, IL8
20taurodeoxycholate4411.2SCT, CLPS, SST, CCK
21leukotriene b444 59 2413.1ELANE, PLA2G1B, MPO, IL6, IL8
22octreotide44 59 28 1114.1SCT, CCK, MPO, SST
23homocysteine44 2412.1SULT1A3, IL18, RETN, CRP, APOC2
24cysteine4411.1CFTR, IL8, IL18, RETN, PRSS2, ELANE
25cyclosporin a44 28 5913.1CFTR, CCK, ELANE, SCT
26fibrinogen4411.1SULT1A3, ELANE, IL6, IL18, CRP, RETN
27glucose4411.1CCK, SCT, REG3A, APOC2
28aspartate4411.1RETN, SCT, CFTR, SULT1A3, CLPS
29pentoxifylline44 1112.1IL18, MPO, ELANE
30anaphylatoxin4411.1MPO, IL8, IL6, ELANE
31omeprazole44 28 49 11 2415.1CRP, CCK, SCT, SST
32gabexate mesilate4411.1SST, ELANE
33endotoxin4411.0RETN, PLA2G1B
34sivelestat4411.0ELANE, IL8, IL6
35ulinastatin4411.0ELANE, MPO
36etanercept44 49 1113.0IL8, CRP, IL18, IL6
37pge24411.0SST
38nafamostat mesilate4411.0IL18, MPO, ELANE
39curcumin4411.0SULT1A3, CFTR, IL18, IL8, IL6
40rebamipide4411.0IL6, IL8, MPO
41indomethacin44 59 28 1114.0SCT, CFTR, PLA2G1B
42loxiglumide4410.9SCT, SST, CCK
43cilomilast4410.9IL8, MPO, ELANE
44anakinra44 1111.9CRP, IL6, IL18
45serine4410.9MPO, SPINK1, IL8, IL18, SCT, APOC2
46taurine chloramine4410.8IL6, IL8, MPO
47vitamin a44 11 2412.8APOC2, RETN, ELANE, IL18, CRP
48glutamine4410.8CFTR, ELANE, IL18, CRP, SCT, CCK
49azithromycin44 1111.7CFTR, CRP, IL8
50vegf4410.6IL8, IL6, SST, IL18, RETN, MPO

GO Terms for genes affiliated with Acute Pancreatitis

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16Gene Ontology
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Cellular components related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4ELANE, CCK, APOC2, SCT, CRP, PRSS2
2extracellular spaceGO:00561511.0CCK, APOC2, CRP, MPO, PRSS2, SST
3secretory granuleGO:03014110.7ELANE, PLA2G1B, MPO

Biological processes related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00695310.8IL6, REG3A, CRP
2negative regulation of chemokine biosynthetic processGO:04507910.8ELANE, IL6
3inflammatory responseGO:00695410.7IL6, IL8, IL18, CRP
4response to yeastGO:00187810.7MPO, ELANE
5neutrophil mediated immunityGO:00244610.7PLA2G1B, IL6
6positive regulation of immune responseGO:05077810.6PLA2G1B, ELANE
7negative regulation of lipid storageGO:01088810.5CRP, IL6
8response to drugGO:04249310.4APOC2, SST, IL6, CFTR

Molecular functions related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7RETN, SST, SCT, CCK

Products for genes affiliated with Acute Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet