MCID: ACT027
MIFTS: 61

Acute Pancreatitis

Categories: Gastrointestinal diseases, Rare diseases, Bone diseases, Immune diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Acute Pancreatitis

MalaCards integrated aliases for Acute Pancreatitis:

Name: Acute Pancreatitis 12 72 36 28 51 14 69 59
Pancreatitis, Acute Necrotizing 69
Acute Necrotizing Pancreatitis 12
Acute Pancreatitis [ambiguous] 12
Acute Pancreatitis Unspecified 12
Pancreatitis Necrotizing 12
Necrotizing Pancreatitis 51
Acute Pancreatitis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2913
ICD10 32 K85 K85.9
ICD9CM 34 577.0
NCIt 46 C95437
KEGG 36 H01681

Summaries for Acute Pancreatitis

PubMed Health : 59
About acute pancreatitis: Acute pancreatitis is an inflammation of the pancreas that typically causes very sudden and very severe stomach ache. The most common causes are gallstones and excessive alcohol consumption.Acute pancreatitis can have serious complications, so it is typically treated in the hospital. Most of the time it passes without any serious problems developing in about one to two weeks. But in more severe cases of pancreatitis, treating the complications may take up to several months. Complications of pancreatitis can be fatal.

MalaCards based summary : Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to recurrent acute pancreatitis and peritonitis. An important gene associated with Acute Pancreatitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Acetaminophen and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

Related Diseases for Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 445)
# Related Disease Score Top Affiliating Genes
1 recurrent acute pancreatitis 33.9 LPL SCT SPINK1
2 peritonitis 30.5 CRP CXCL8 IL10 IL6
3 hemorrhagic fever with renal syndrome 30.4 CRP IL10 IL6
4 gastroenteritis 30.4 CRP CXCL8 IL10 IL6
5 dengue hemorrhagic fever 30.3 CXCL8 IL10 IL6
6 acute cholangitis 30.3 CRP IL6
7 colitis 30.1 CXCL8 IL10 IL6 MPO
8 leptospirosis 30.1 CRP CXCL8 IL10 IL6
9 acalculous cholecystitis 30.0 CCK CRP
10 aortic aneurysm, familial abdominal, 1 30.0 CRP ELANE IL6
11 pancreatitis 30.0 CCK CPB1 CRP LPL PLA2G2A PNLIP
12 ulcerative colitis 30.0 CRP CXCL8 IL10 IL6 MPO
13 microscopic polyangiitis 30.0 IL10 MPO
14 meningitis 30.0 CRP CXCL8 IL10 IL6
15 polyarteritis nodosa 29.9 CRP IL6 MPO
16 cytomegalovirus infection 29.9 CXCL8 IL10 IL6
17 alcoholic hepatitis 29.9 CXCL8 IL10 IL6
18 mouth disease 29.9 CRP IL10 IL6
19 toxic shock syndrome 29.8 CXCL8 IL10 IL6
20 acute respiratory distress syndrome 29.8 CXCL8 ELANE IL6
21 streptococcal toxic-shock syndrome 29.8 CXCL8 IL6
22 morbid obesity 29.7 CCK CRP LPL
23 gallbladder disease 29.7 CCK IL10 SST
24 arthritis 29.7 CXCL8 IL10 IL18 IL6
25 brucellosis 29.7 CRP CXCL8 IL10 IL18 IL6
26 adult respiratory distress syndrome 29.7 CXCL8 ELANE IL10 IL6
27 systemic lupus erythematosus 29.7 CRP ELANE IL10 IL18 IL6 MPO
28 visceral leishmaniasis 29.6 CRP CXCL8 IL10 IL18
29 duodenal ulcer 29.6 CCK CXCL8 SCT SST
30 peptic ulcer disease 29.6 CXCL8 IL10 SCT
31 body mass index quantitative trait locus 11 29.5 CCK CRP IL18 IL6 LPL PNLIP
32 appendicitis 29.5 CRP CXCL8 IL10 IL6 MPO
33 alcoholic pancreatitis 29.3 CCK LPL SCT SPINK1
34 rheumatoid arthritis 29.3 CRP CXCL8 IL10 IL18 IL6
35 pneumonia 29.2 CRP CXCL8 ELANE IL10 IL6 MPO
36 exocrine pancreatic insufficiency 29.2 CCK PNLIP SCT
37 pancreatic cancer 29.0 CCK CXCL8 REG3A SCT SPINK1 SST
38 cystic fibrosis 28.9 CXCL8 ELANE MPO PNLIP REG3A SCT
39 inflammatory bowel disease 28.6 CRP CXCL8 ELANE IL10 IL18 IL6
40 steatorrhea 28.2 CCK PNLIP SCT SST TMPRSS15
41 pancreatitis, hereditary 28.2 CCK ELANE LPL PNLIP REG3A SCT
42 hyperlipoproteinemia, type i 11.2
43 pancreatitis, pediatric 10.9
44 cold agglutinin disease 10.6 CRP IL6
45 recurrent corneal erosion 10.6 CXCL8 IL6
46 bagassosis 10.6 CXCL8 IL6
47 diabetic foot ulcers 10.6 CRP IL6
48 ischemic heart disease 10.6 CRP IL6 LPL
49 multicentric castleman disease 10.5 CRP IL10 IL6
50 acute transverse myelitis 10.5 CXCL8 IL10 IL6

Comorbidity relations with Acute Pancreatitis via Phenotypic Disease Network (PDN): (show all 39)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Vascular Insufficiency of Intestine
Alcohol Abuse Alcoholic Gastritis
Alcoholic Hepatitis Alcoholic Liver Cirrhosis
Atrophic Gastritis Biliary Tract Disease
Biliary Tract Neoplasm Cholangitis
Cholecystitis Cholestasis
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Duodenitis
Esophageal Disease Esophagitis
Gallbladder Disease Heart Disease
Hepatitis Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypothyroidism
Intestinal Obstruction Iron Deficiency Anemia
Irritable Bowel Syndrome Ischemic Heart Disease
Liver Disease Pancreatic Agenesis 1
Pancreatic Cancer Pancreatitis, Hereditary
Paralytic Ileus Postcholecystectomy Syndrome
Protein-Energy Malnutrition Respiratory Failure
Strawberry Gallbladder

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to Acute Pancreatitis

Symptoms & Phenotypes for Acute Pancreatitis

GenomeRNAi Phenotypes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

25 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.78 CPB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.78 PLA2G6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.78 SPINK1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.78 SPINK1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.78 MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.78 CPB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.78 PLA2G6
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.78 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.78 PLA2G6
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.78 SPINK1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.78 SPINK1 CPB1 MPO PLA2G6
15 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.78 CPB1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.78 CPB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.78 MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.78 CPB1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.78 MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.78 PLA2G6
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.78 SPINK1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.78 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.78 MPO
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 CPB1 PLA2G6
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 CPB1

MGI Mouse Phenotypes related to Acute Pancreatitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 CCK CRP CTSB ELANE IL10 IL18
2 immune system MP:0005387 9.36 CRP CTSB ELANE IL10 IL18 IL6

Drugs & Therapeutics for Acute Pancreatitis

PubMedHealth treatment related to Acute Pancreatitis: 59

No treatment is available for dealing with the root cause of pancreatitis. But there are a number of options for reducing strain on the pancreas and relieving symptoms. Because fluid levels can drop due to acute pancreatitis, the first step is to prevent dehydration by using infusion therapy. A hollow needle inserted in an arm vein is used to release a solution into the bloodstream. Medication is used to provide relief from pain, nausea and vomiting. Stronger painkillers such as opioids are sometimes needed, and they may make you feel drowsy or light-headed.Solid foods are avoided until the pain recedes and appetite returns to give the pancreas a chance to recuperate. In mild cases of pancreatitis it is sometimes possible to return to eating solid foods after just a few days. If the symptoms last longer, artificial feeding may be necessary to supply your body with enough nutrients.If the pancreatitis is caused by gallstones, the stones may need to be removed using endoscopic retrograde cholangiography. After treatment the gallbladder is surgically removed to prevent further episodes.

Drugs for Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Clonidine Approved Phase 4 4205-90-7 2803
3 Nefopam Approved, Investigational Phase 4 13669-70-0
4
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1 84057-95-4 175805 71273
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3 27203-92-5 33741
7
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
9
Meropenem Approved, Investigational Phase 4,Phase 1,Phase 2 119478-56-7 441130 64778
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Somatostatin Approved, Investigational Phase 4,Phase 3 38916-34-6, 51110-01-1 53481605
12
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
13
Indomethacin Approved, Investigational Phase 4,Phase 3 53-86-1 3715
14
Ketorolac Approved Phase 4,Phase 2,Phase 3 74103-06-3, 66635-83-4 3826
15
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
16 Racepinephrine Approved Phase 4 329-65-7
17
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
18
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
19
Protein C Approved Phase 4
20
Octreotide Approved, Investigational Phase 4 83150-76-9 6400441 383414
21
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
22
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 32051 23994
23
Azathioprine Approved Phase 4 446-86-6 2265
24
Thioguanine Approved Phase 4 154-42-7 2723601
25
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
26 Fat Emulsions, Intravenous Phase 4
27 Parenteral Nutrition Solutions Phase 4
28 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
29 Soybean oil, phospholipid emulsion Phase 4
30 Adjuvants, Anesthesia Phase 4,Phase 2,Phase 3,Phase 1
31 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
32 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
33 Analgesics, Opioid Phase 4,Phase 2,Phase 3,Phase 1
34 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
35 Anesthetics, General Phase 4,Phase 2,Phase 3,Phase 1
36 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3,Phase 1
37 Anesthetics, Local Phase 4,Phase 2,Phase 3
38 Antipyretics Phase 4
39 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
40 Narcotics Phase 4,Phase 2,Phase 3,Phase 1
41 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
42 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
44 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Anti-Infective Agents, Local Phase 4
46 Antiparasitic Agents Phase 4
47 Antiprotozoal Agents Phase 4
48 Chlorhexidine gluconate Phase 4
49 Dermatologic Agents Phase 4,Phase 2,Phase 3
50 Disinfectants Phase 4

Interventional clinical trials:

(show top 50) (show all 181)

# Name Status NCT ID Phase Drugs
1 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
2 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
3 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
4 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
5 Imipenem Prophylaxis in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
6 Activated Protein C in Severe Acute Pancreatitis Completed NCT01017107 Phase 4 Activated protein C
7 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
8 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
9 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4 Conservative treatment
10 Early Enteral Nutrition for Severe Acute Pancreatitis Completed NCT00995098 Phase 4
11 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
12 Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers Completed NCT00222092 Phase 4
13 A Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
14 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
15 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
16 Treatment of Acute Pancreatitis With Ketorolac Recruiting NCT02885441 Phase 4 Ketorolac;Placebo
17 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Recruiting NCT02839356 Phase 4 epinephrine;normal saline
18 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
19 Oral Resveratrol to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02947932 Phase 4 Resveratrol;Indomethacin
20 Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Not yet recruiting NCT03342807 Phase 4 Insulin
21 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal Not yet recruiting NCT03082469 Phase 4
22 COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Not yet recruiting NCT02964403 Phase 4 Cox-2;Indomethacin
23 Ulinastatin in Severe Acute Pancreatitis Suspended NCT01132521 Phase 4 ulinastatin;placebo
24 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
25 Epidural Anesthesia in Acute Pancreatitis Unknown status NCT02617199 Phase 2, Phase 3 Epidural anesthesia;intravenous analgesia
26 Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis Unknown status NCT00506337 Phase 2, Phase 3 Qingyi granules
27 Efficacy of Administration of Somatostatin in the Prevention of Post-endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis Unknown status NCT01060826 Phase 3 somatostatin, intravenous bolus;somatostatin
28 Effect of Traditional Chinese Medicine on GI Function Recovery and Nutrition Support in SAP Unknown status NCT00508729 Phase 2, Phase 3 Qingyi granules
29 Safety and Efficacy in LPL-Deficient Subjects of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X] Unknown status NCT01109498 Phase 2, Phase 3 Mycophenolate mofetil;cyclosporine
30 MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA) Completed NCT01128478 Phase 2, Phase 3
31 Pentoxifylline Treatment in Acute Pancreatitis (AP) Completed NCT02487225 Phase 3 Pentoxifylline;Placebo
32 Indomethacin Decreases Post-ERCP Pancreatitis Completed NCT02110810 Phase 3 Indomethacin;2.6-g suppository of glycerin
33 Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis Completed NCT01977118 Phase 2, Phase 3 streptokinase
34 Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis Completed NCT02641561 Phase 3 Indomethacin;Lactated Ringer's Solution;Normal Saline;Placebo
35 Does Glyceryl Nitrate Prevent Post-Endoscopic Retrograde Cholangiopancreaticography (ERCP) Pancreatitis? Completed NCT00121901 Phase 3 glyceryl nitrate
36 Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting Completed NCT01834430 Phase 3
37 A Prospective Validation Study of Albumin Kinetics With Tracer 123 I-HSA Completed NCT01686776 Phase 3
38 A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes Completed NCT02152371 Phase 3 Dulaglutide;Placebo;Insulin Glargine;Metformin
39 Study of How Dulaglutide Compares to Placebo in Participants With Type 2 Diabetes Who Are Also on Sulfonylurea Therapy (AWARD-8) Completed NCT01769378 Phase 3 Placebo;Dulaglutide;Glimepiride
40 A Study Comparing the Effect of Dulaglutide With Liraglutide in Type 2 Diabetes Completed NCT01624259 Phase 3 LY2189265;Liraglutide;Metformin
41 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
42 A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus Completed NCT02597049 Phase 3 Dulaglutide;Placebo
43 A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis Recruiting NCT02692391 Phase 3 Indomethacin;Placebo
44 Fluid Resuscitation in Acute Pancreatitis Recruiting NCT02709044 Phase 2, Phase 3 Ringer lactate
45 Rectal Indomethacin to Prevent Post-Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis Terminated NCT01774604 Phase 3 Indomethacin;Placebo
46 Efficacy Study of Glyceryl-Trinitrate Patch and Parecoxib (Valdecoxib) for the Prevention of Pancreatitis After Endoscopic Retrograde Cholangiopancreatography (ERCP) Terminated NCT00419549 Phase 2, Phase 3 Glyceryl - trinitrate;Valdecoxib
47 The Clinical Study of Acute Pancreatitis Treated by TongFuSan Unknown status NCT02204189 Phase 1, Phase 2 TongFuSan
48 Comparing the Outcome in Patients of Acute Pancreatitis, With and Without Prophylactic Antibiotics Completed NCT02212392 Phase 1, Phase 2 Meropenem
49 Enhanced Recovery in Acute Pancreatitis Completed NCT02813876 Phase 2
50 Effects Of Fish Oil Emulsion On Severe Acute Pancreatitis Patients Completed NCT01745861 Phase 2

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

Genetic tests related to Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Pancreatitis 28

Anatomical Context for Acute Pancreatitis

MalaCards organs/tissues related to Acute Pancreatitis:

38
Pancreas, Lung, Liver, Neutrophil, Testes, Monocytes, Endothelial

Publications for Acute Pancreatitis

Articles related to Acute Pancreatitis:

(show top 50) (show all 1746)
# Title Authors Year
1
Etiology Is Linked to the Length of Admission in Patients With Acute Pancreatitis: Is Novel Endoscopy an Unrecognized Cause? ( 29424812 )
2018
2
Recurrent Acute Pancreatitis in Children: Do not forget the "Worms". ( 29095350 )
2018
3
Autophagy Strengthens Intestinal Mucosal Barrier by Attenuating Oxidative Stress in Severe Acute Pancreatitis. ( 29427225 )
2018
4
Pancreaticoportal Fistula Formation as a Consequence of Recurrent Acute Pancreatitis: Clinical and Imaging Considerations. ( 29441227 )
2018
5
Serum Osteopontin Is Associated With Organ Failure in Patients With Acute Pancreatitis. ( 29424811 )
2018
6
The protective effects of rutaecarpine on acute pancreatitis. ( 29435045 )
2018
7
Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-cohort Study in Denmark. ( 29432727 )
2018
8
Acute pancreatitis: ascaris in the pancreatic duct. ( 29452432 )
2018
9
S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. ( 29441717 )
2018
10
Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis. ( 29439880 )
2018
11
Cav 1.2 and Cav 2.2 expression is regulated by different endogenous ghrelin levels in pancreatic acinar cells during acute pancreatitis. ( 29436604 )
2018
12
Correction:<i>Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol</i>. ( 29440166 )
2018
13
Fluid resuscitation with lactated Ringer's solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial. ( 29435315 )
2018
14
What may cause fetus loss from acute pancreatitis in pregnancy: Analysis of 54 cases. ( 29443736 )
2018
15
Acute pancreatitis during GLP-1 receptor agonist treatment. A case report. ( 29440961 )
2018
16
STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis. ( 29425920 )
2018
17
Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. ( 29350372 )
2018
18
Venous Thromboembolism Is Associated With Adverse Outcomes in Hospitalized Patients With Acute Pancreatitis: A Population-Based Cohort Study. ( 28902787 )
2017
19
Endoscopic Placement of a U-Shaped Plastic Stent in Patients With Recurrent Acute Pancreatitis and Incomplete Pancreas Divisum. ( 29215619 )
2017
20
Diabetes Mellitus Secondary to Acute Pancreatitis in a Child with Wolf-Hirschhorn Syndrome. ( 29204299 )
2017
21
Acute pancreatitis as an initial manifestation of parathyroid carcinoma: A case report and literature review. ( 29095277 )
2017
22
Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: long-term follow-up study. ( 29078749 )
2017
23
Acute pancreatitis: is early CT necessary? ( 28936579 )
2017
24
Anorectal Malignant Melanoma Presenting as Acute Pancreatitis. ( 28918842 )
2017
25
'Treat the Cause': the NCEPOD report on acute pancreatitis. ( 28067554 )
2017
26
Increased Circulating CD4+CD25+CD127low/neg Regulatory T-cells as a Prognostic Biomarker in Acute Pancreatitis. ( 28953205 )
2017
27
A rare cause of recurrent acute pancreatitis: duodenum intussusception by a fenestrated duodenal web. ( 28342893 )
2017
28
Left Hepatic Artery Pseudoaneurysm Caused by Acute Pancreatitis. ( 28068658 )
2017
29
sPD-L1 Expression is Associated with Immunosuppression and Infectious Complications in Patients with Acute Pancreatitis. ( 28513984 )
2017
30
Hipertriglyceridemia induced acute pancreatitis in pregnancy. ( 28939055 )
2017
31
Fatal cerebral hemorrhage associated with acute pancreatitis: A case report. ( 29390292 )
2017
32
High-Density Lipoprotein Cholesterol, Blood Urea Nitrogen, and Serum Creatinine Can Predict Severe Acute Pancreatitis. ( 28904946 )
2017
33
Acute pancreatitis in hand, foot and mouth disease caused by Coxsackievirus A16: case report. ( 29158768 )
2017
34
Doxycycline-Induced Acute Pancreatitis: A Rare Adverse Event. ( 28912911 )
2017
35
Disseminated Intravascular Coagulation on Admission Predicts Complications and Poor Prognosis of Acute Pancreatitis: Analysis of the Nationwide Epidemiological Survey in Japan. ( 28085757 )
2017
36
A Rare Etiology of Idiopathic Recurrent Acute Pancreatitis. ( 28384455 )
2017
37
A rare etiology of idiopathic acute pancreatitis. ( 28937028 )
2017
38
Acute Non-Fulminant Viral Hepatitis E Presenting with Acute Pancreatitis-An Unusual Presentation. ( 28951695 )
2017
39
Addison's Disease Mimicking as Acute Pancreatitis: A Case Report. ( 28571196 )
2017
40
Eosinophilic Pancreatitis: A Rare Cause of Recurrent Acute Pancreatitis. ( 28611564 )
2017
41
The Role of Gut-brain Axis in Regulating Glucose Metabolism After Acute Pancreatitis. ( 28055028 )
2017
42
Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis. ( 28368336 )
2017
43
Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature. ( 28507728 )
2017
44
Plasmapheresis for recurrent acute pancreatitis from hypertriglyceridemia. ( 28670087 )
2017
45
Prognostic value of admission red blood cell distribution width in acute pancreatitis: a systematic review. ( 28936436 )
2017
46
Hypertriglyceridemia, an important and independent risk factor for acute pancreatitis in patients with type 2 diabetes mellitus. ( 28450786 )
2017
47
The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies. ( 28067818 )
2017
48
Acute Pancreatitis Secondary to Severe Hypertriglyceridemia: Management of Severe Hypertriglyceridemia in Emergency Setting. ( 28725307 )
2017
49
Hemolytic-uremic Syndrome Complicating Acute Pancreatitis. ( 28904486 )
2017
50
Platelet Distribution Width Levels Can Be a Predictor in the Diagnosis of Persistent Organ Failure in Acute Pancreatitis. ( 29445395 )
2017

Variations for Acute Pancreatitis

Expression for Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for Acute Pancreatitis

GO Terms for Acute Pancreatitis

Cellular components related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 CCK CPB1 CRP CTSB CXCL8 ELANE
2 extracellular space GO:0005615 9.58 CCK CPB1 CRP CTSB CXCL8 ELANE
3 secretory granule GO:0030141 9.33 ELANE MPO PLA2G2A

Biological processes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.74 CRP IL6 PLA2G2A
2 inflammatory response GO:0006954 9.73 CRP CXCL8 IL10 IL18 IL6 REG3A
3 positive regulation of inflammatory response GO:0050729 9.69 IL18 LPL PLA2G2A
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.67 ELANE IL18 IL6
5 antimicrobial humoral response GO:0019730 9.65 ELANE PLA2G2A REG3A
6 lipid catabolic process GO:0016042 9.62 LPL PLA2G2A PLA2G6 PNLIP
7 acute-phase response GO:0006953 9.58 CRP IL6 REG3A
8 low-density lipoprotein particle remodeling GO:0034374 9.56 MPO PLA2G2A
9 response to molecule of bacterial origin GO:0002237 9.55 CXCL8 IL10
10 neutrophil activation GO:0042119 9.54 CXCL8 IL18
11 negative regulation of lipid storage GO:0010888 9.52 CRP IL6
12 type 2 immune response GO:0042092 9.46 IL10 IL18
13 response to yeast GO:0001878 9.43 ELANE MPO
14 negative regulation of chemokine biosynthetic process GO:0045079 9.37 ELANE IL6
15 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.33 IL18 LPL PLA2G2A
16 regulation of receptor activity GO:0010469 9.17 CCK CXCL8 IL10 IL18 IL6 SCT
17 negative regulation of growth of symbiont in host GO:0044130 9.13 ELANE IL10 MPO

Molecular functions related to Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.56 CPB1 CTSB ELANE LPL PLA2G2A PLA2G6
2 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL18 IL6

Sources for Acute Pancreatitis

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