MCID: ACT027
MIFTS: 60

Acute Pancreatitis malady

Gastrointestinal, Endocrine categories

Summaries for Acute Pancreatitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

MalaCards: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to recurrent acute pancreatitis and hypertriglyceridemia. An important gene associated with Acute Pancreatitis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways are Transcriptional misregulation in cancer and Pancreatic secretion. The compounds lipid and testosterone have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lymph node, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Acute Pancreatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Endocrine


Aliases & Descriptions:

acute pancreatitis 8 10 45 61
pancreatitis, acute necrotizing 61
acute necrotizing pancreatitis 8
acute pancreatitis unspecified 8
pancreatitis necrotizing 8
necrotizing pancreatitis 45
acute pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:2913
ICD9CM27 577.0
ICD1025 K85

Related Diseases for Acute Pancreatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the pancreatitis, chronic family:

acute pancreatitis pancreatitis
autoimmune pancreatitis autoimmune pancreatitis type 2
autoimmune pancreatitis type 1 recurrent acute pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 363)
idRelated DiseaseScoreTop Affiliating Genes
1recurrent acute pancreatitis31.5SCT, CFTR, SPINK1
2hypertriglyceridemia31.0APOC2
3pancreatitis, chronic30.7CCK, APOC2, SCT, SST, REG3A, CFTR
4hepatitis c30.6IL18
5cystic fibrosis30.5SCT, MPO, REG3A, IL8, CFTR, SPINK1
6adenoma30.5SCT, SST, SPINK1
7sepsis30.4CRP, MPO, RETN, IL18, IL8, IL6
8alcoholic pancreatitis30.4CCK, SCT, CFTR, SPINK1, CPB1, ELANE
9acute myocardial infarction30.4SULT1A3, RETN, CRP
10hypercalcemia30.4SCT, SPINK1
11hereditary pancreatitis30.4CFTR, SPINK1
12acute leukemia30.4RETN, MPO
13systemic lupus erythematosus30.3CRP, MPO, IL18, IL6, SULT1A3
14ulcerative colitis30.3CRP
15thromboembolism30.2SULT1A3
16arthritis30.1CRP, MPO, RETN, IL18, IL8, IL6
17graves' disease30.1MPO
18steatorrhea29.8CCK, SCT, SST, CLPS, CFTR, ELANE
19duodenal ulcer29.8IL8, SST, SCT, CCK
20colorectal cancer29.8CCK, PRSS2, REG3A, SPINK1
21adult respiratory distress syndrome29.8MPO, IL8, IL6, ELANE
22acromegaly29.8CCK, SST, RETN
23nephritis29.8SULT1A3, IL18, MPO
24crohn's disease29.8CRP
25polyarteritis nodosa29.8MPO
26hepatitis b29.8SULT1A3
27uremia29.8RETN, CRP
28aortic aneurysm29.8CRP
29appendicitis29.8CRP
30familial mediterranean fever29.8CRP
31hyperhomocysteinemia29.8CRP
32psoriatic arthritis29.8CRP
33anorexia nervosa29.8CCK, RETN
34hepatitis a10.4
35pancreatitis, idiopathic10.4
36obstructive jaundice10.4
37acute cholangitis10.4
38diabetic ketoacidosis10.3
39thrombotic thrombocytopenic purpura10.3
40hemorrhagic fever10.3
41choledochal cyst10.3
42somatostatin analog10.3
43ascariasis10.3
44primary hyperparathyroidism10.3
45small cell carcinoma10.3
46annular pancreas10.3
47pancreatitis, pediatric10.3
48ileus10.3
49hereditary angioedema10.2
50bile reflux10.2

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to acute pancreatitis

Clinical Features for Acute Pancreatitis

Drugs & Therapeutics for Acute Pancreatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Acute Pancreatitis

Search NIH Clinical Center for Acute Pancreatitis

Search CenterWatch for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

Anatomical Context for Acute Pancreatitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acute Pancreatitis:

33
Liver, Kidney, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Thymus, Heart, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Breast, Prostate, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Pancreatic islet, Pituitary

Animal Models for Acute Pancreatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3ELANE, CCK, SCT, CRP, MPO, SST
2MP:000538711.1MPO, SST, IL18, IL8, IL6, CFTR
3MP:000538110.5CLPS, IL6, PLA2G1B, CFTR, SPINK1

Publications for Acute Pancreatitis

Sources:
51PubMed
See all sources

Articles related to Acute Pancreatitis:

(show top 50)    (show all 1608)
idTitleAuthorsYear
1
Spontaneous fistulisation of infected walled-off necrosis (WON) into the duodenum in a patient following acute necrotising pancreatitis. (24414192)
2014
2
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
3
A comparison of the BISAP score and serum procalcitonin for predicting the severity of acute pancreatitis. (23682226)
2013
4
Nilotinib-associated acute pancreatitis. (23300151)
2013
5
Opioids for acute pancreatitis pain. (23888429)
2013
6
A minimally invasive management for abdominal compartment syndrome in severe acute pancreatitis. (24353548)
2013
7
Predictors of surgery in patients with severe acute pancreatitis managed by the step-up approach. (22968079)
2013
8
The protective effects of taurine on experimental acute pancreatitis in a rat model. (23536517)
2013
9
Nitric oxide synthase inhibition reduces albumin induced lung damage in acute pancreatitis. (23719592)
2013
10
Prediction of the severity of acute pancreatitis on admission by urinary trypsinogen activation peptide: a meta-analysis. (23901239)
2013
11
Early nasogastric tube feeding versus nil per os in mild to moderate acute pancreatitis: a randomized controlled trial. (23340042)
2013
12
Right hepatic artery pseudoaneurysm complicating acute pancreatitis: a case report. (23147463)
2013
13
Acute pancreatitis due to hypercalcemia related to bone metastasis from breast cancer. (21945957)
2013
14
Wernicke encephalopathy presenting in a patient with severe acute pancreatitis. (22233960)
2012
15
Successful endoscopic decompression for intramural duodenal hematoma with gastric outlet obstruction complicating acute pancreatitis. (22977802)
2012
16
A Case of Recurrent Acute Pancreatitis due to Pancreatic Arteriovenous Malformation. (20479928)
2010
17
Pathophysiology of acute and infected pancreatitis. (20180751)
2010
18
Pathogenic aspects of pulmonary complications in acute pancreatitis patients. (19357034)
2009
19
The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis]. (19220961)
2009
20
A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. (18651203)
2008
21
Should urgent ERCP be performed in patients with acute biliary pancreatitis without acute cholangitis? (18628734)
2008
22
Metastatic neuroendocrine tumor of unknown primary presenting as acute pancreatitis. (18414070)
2008
23
Acute abdomen due to acute pancreatitis--a rare presentation of leptospirosis. (19263694)
2008
24
Resistin-- a new laboratory marker useful in diagnosis of acute pancreatitis?]. (17679375)
2007
25
Kinetics of group IB and IIA phospholipase A2 during low-volume continuous hemodiafiltration in severe acute pancreatitis. (17470210)
2007
26
Alteration of peripheral blood lymphocyte subsets in acute pancreatitis. (16981265)
2006
27
Purtscher's like retinopathy as the presenting feature of acute alcoholic pancreatitis. (15803177)
2006
28
Management of acute pancreatitis: current knowledge and future perspectives. (16759369)
2006
29
Neurogenic inflammation in acute pancreatitis. (16186661)
2005
30
Repeated obstructive jaundice and acute pancreatitis caused by metastatic liver tumor: an unusual case. (15783035)
2005
31
Does acute alcoholic pancreatitis precede the chronic form or is the opposite true? A histological study. (15128075)
2004
32
Trypsinogen-2 and trypsinogen activation peptide (TAP) in urine of patients with acute pancreatitis. (12850473)
2003
33
From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene. (12629264)
2003
34
Increased expression of 19-kD interacting protein-3-like protein and the relationship to apoptosis in the lung of rats with severe acute pancreatitis. (14530762)
2003
35
Levels of the chemokines growth-related oncogene alpha and epithelial neutrophil-activating protein 78 are raised in patients with severe acute pancreatitis. (11972545)
2002
36
Do normal leucocyte count and C-reactive protein on admission to hospital exclude a life-threatening attack of acute pancreatitis? (12558085)
2002
37
Acute pancreatitis resulting from a nonfunctional islet cell tumor detected and localized by EUS. (11756932)
2002
38
The dynamics of blood serum middle-molecule peptides in the prognosis of the course of acute pancreatitis]. (10709267)
1999
39
Intramucosal acidosis and the inflammatory response in acute pancreatitis. (10484003)
1999
40
Somatostatin attenuates microcirculatory impairment in acute sodium taurocholate-induced pancreatitis. (9539654)
1998
41
The clinical utility of the quotient of lipase-amylase and polymorphonuclear elastase in acute pancreatitis]. (9580441)
1998
42
Megacolon as a presenting finding of acute pancreatitis associated with chronic ulcerative colitis: unusual presentation of an unusual association. (7771399)
1995
43
Interleukin-6 in the early assessment of acute pancreatitis. (8244123)
1993
44
Informativeness of the methods of early clinical laboratory diagnosis of acute pancreatitis]. (1630081)
1992
45
Carboxylic ester hydrolase. A sensitive serum marker and indicator of severity of acute pancreatitis. (1709672)
1991
46
A case of acute intermittent porphyria with acute pancreatitis. (1826102)
1991
47
Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. (2554845)
1989
48
Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. (6786954)
1981
49
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952
50
Recurrent acute pancreatitis; observations on etiology and surgical treatment. (18108700)
1948

Genetic Variations for Acute Pancreatitis

Expression for genes affiliated with Acute Pancreatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for genes affiliated with Acute Pancreatitis

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN
See all sources

Pathways related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7ELANE, IL6, IL8, MPO
210.7CPB1, CFTR, PLA2G1B, PRSS2
310.7IL6, MPO, CRP
410.7MPO, IL6, ELANE
5
Cytokine production by Th17 cells in CF (Mouse model)
10.7IL8, IL6, CFTR
6
Immune response Bacterial infections in normal airways
10.7CFTR, IL6, IL8
7
Hide members
10.7IL6, IL8, IL18
810.7IL6, IL8, IL18
910.7IL18, IL8, IL6
1010.5IL18
1110.5IL18
1210.5IL8

Compounds for genes affiliated with Acute Pancreatitis

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1lipid4511.5IL18, RETN, IL6, GP2, PLA2G1B, SULT1A3
2testosterone45 60 11 2414.5CCK, SCT, CRP, RETN, IL18, CFTR
3acetylcholine45 50 29 11 2415.4MPO, ELANE, CRP, CCK, SCT, SST
4retinoic acid45 2412.4SCT, CFTR, ELANE, IL6, IL18, MPO
5lactate4511.4ELANE, IL6, IL18, SST, MPO, CRP
6creatinine4511.4MPO, APOC2, CRP, SPINK1, SULT1A3, IL6
7trypsinogen4511.4CFTR, ELANE, SPINK1, REG3A, PRSS2, SCT
8cholesterol45 29 11 2414.4CLPS, CCK, APOC2, CRP, RETN, IL6
9epinephrine45 11 2413.4ELANE, SCT, SST, SULT1A3, CFTR, IL18
10histamine45 29 2413.3CCK, MPO, SST, IL18, IL8, IL6
11dexamethasone45 50 29 1114.3CFTR, RETN, IL6, PLA2G1B, CCK, SULT1A3
12isoproterenol45 1112.3ELANE, SST, SCT, RETN, IL18, CFTR
13aspirin45 50 29 2414.3ELANE, CCK, CRP, IL18, CFTR, SULT1A3
14norepinephrine45 11 2413.3CCK, RETN, CFTR, SULT1A3, ELANE
15cerulein4511.3ELANE, IL6, SCT, CCK, MPO
168-isoprostane4511.2CRP, MPO, RETN, IL8, IL6
17c-peptide4511.2SST, RETN, SCT, CRP, CCK
18neopterin4511.2IL18, IL8, IL6, ELANE, CRP
19n acetylcysteine4511.2CRP, MPO, IL6, CFTR, IL18, IL8
20taurodeoxycholate4511.2SCT, CLPS, SST, CCK
21leukotriene b445 60 2413.1ELANE, PLA2G1B, MPO, IL6, IL8
22octreotide45 60 29 1114.1SCT, CCK, MPO, SST
23homocysteine45 2412.1SULT1A3, IL18, RETN, CRP, APOC2
24cysteine4511.1CFTR, IL8, IL18, RETN, PRSS2, ELANE
25cyclosporin a45 29 6013.1CFTR, CCK, ELANE, SCT
26fibrinogen4511.1SULT1A3, ELANE, IL6, IL18, CRP, RETN
27glucose4511.1CCK, SCT, REG3A, APOC2
28aspartate4511.1RETN, SCT, CFTR, SULT1A3, CLPS
29pentoxifylline45 1112.1IL18, MPO, ELANE
30anaphylatoxin4511.1MPO, IL8, IL6, ELANE
31omeprazole45 29 50 11 2415.1CRP, CCK, SCT, SST
32gabexate mesilate4511.1SST, ELANE
33endotoxin4511.0RETN, PLA2G1B
34sivelestat4511.0ELANE, IL8, IL6
35ulinastatin4511.0ELANE, MPO
36etanercept45 50 1113.0IL8, CRP, IL18, IL6
37pge24511.0SST
38nafamostat mesilate4511.0IL18, MPO, ELANE
39curcumin4511.0SULT1A3, CFTR, IL18, IL8, IL6
40rebamipide4511.0IL6, IL8, MPO
41indomethacin45 60 29 1114.0SCT, CFTR, PLA2G1B
42loxiglumide4510.9SCT, SST, CCK
43cilomilast4510.9IL8, MPO, ELANE
44anakinra45 1111.9CRP, IL6, IL18
45serine4510.9MPO, SPINK1, IL8, IL18, SCT, APOC2
46taurine chloramine4510.8IL6, IL8, MPO
47vitamin a45 11 2412.8APOC2, RETN, ELANE, IL18, CRP
48glutamine4510.8CFTR, ELANE, IL18, CRP, SCT, CCK
49azithromycin45 1111.7CFTR, CRP, IL8
50vegf4510.6IL8, IL6, SST, IL18, RETN, MPO

GO Terms for genes affiliated with Acute Pancreatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4ELANE, CCK, APOC2, SCT, CRP, PRSS2
2extracellular spaceGO:00561511.0CCK, APOC2, CRP, MPO, PRSS2, SST
3secretory granuleGO:03014110.7ELANE, PLA2G1B, MPO

Biological processes related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00695310.8IL6, REG3A, CRP
2negative regulation of chemokine biosynthetic processGO:04507910.8ELANE, IL6
3inflammatory responseGO:00695410.7IL6, IL8, IL18, CRP
4response to yeastGO:00187810.7MPO, ELANE
5neutrophil mediated immunityGO:00244610.7PLA2G1B, IL6
6positive regulation of immune responseGO:05077810.6PLA2G1B, ELANE
7negative regulation of lipid storageGO:01088810.5CRP, IL6
8response to drugGO:04249310.4APOC2, SST, IL6, CFTR

Molecular functions related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7RETN, SST, SCT, CCK

Products for genes affiliated with Acute Pancreatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Pancreatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet