Acute Pancreatitis malady

Wikipedia: Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have...⁴⁴ more...

MalaCards: Acute Pancreatitis, also known as acute necrotizing pancreatitis (disorder), is related to alcoholism and hepatitis. An important gene associated with Acute Pancreatitis is CPB1 (carboxypeptidase B1 (tissue)), and among its related pathways are Bacterial infections in CF airways and Immune response_Bacterial infections in normal airways. The compounds nicotine and estradiol have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and liver, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

acute pancreatitis 6 8 32 43 acute necrotizing pancreatitis (disorder) 6 acute pancreatitis unspecified (disorder) 6 acute pancreatitis nos (disorder) 6 pancreatitis, acute necrotizing 43

acute necrotizing pancreatitis 6 acute pancreatitis (disorder) 6 necrotizing pancreatitis 32 pancreatitis necrotizing 6 acute pancreatitis nos 6

Diseases related to acute pancreatitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 978)

id	Related Disease	Score	Top Affiliating Genes
1	alcoholism	32.8	CNR1, SCT, CFTR, GSR, IL1RN, CCK
2	hepatitis	31.9	GPT, IFNA1, TIMP1, SOD2, SLC17A5
3	sepsis	30.0	RETN, SELE, SELP, SERPINC1, SERPINA6, NAMPT
4	pancreatitis	30.0	PIK3C2A, REG1A, REG3A, RETN, CNR1, CNR2
5	gastritis	29.5	SCT, GSTT1, IL1RAPL2, IL1RN, IL8, GHRL
6	thromboembolism	29.5	VWF, SELP, SERPINC1, APOH, F5, F3
7	hypertriglyceridemia	28.3	SELE, SELP, NAMPT, LPL, LEP, LCAT
8	craniopharyngioma	28.2	LEP, INS, IL1A, IL6, ENG, ICAM1
9	acquired immunodeficiency syndrome	28.2	SERPINA1, P4HB, XDH, B2M, CD14, ITGAM
10	hepatitis e	27.4	CD40LG, GPT, IFNA1, F2, ALB, ALPP
11	immunodeficiency	27.3	VIP, BPI, CD79A, CD40LG, ITGB2, MIF
12	hypercalcemia	27.1	SCT, B2M, MGP, IL1A, IL1B, IL2
13	hepatitis b	26.4	IL10, IL18, IL2RA, MBL2, GPT, IFNA1
14	hepatitis c	26.2	SERPINA1, CD40LG, GSR, IL10, IL18, IL2
15	small cell carcinoma	25.5	VIP, VEGFA, BCL2, SCT, BAX, B2M
16	antiphospholipid syndrome	25.2	VWF, SELE, SELP, SERPINC1, VEGFA, P4HB
17	liver cirrhosis	25.2	RETN, CNR1, CNR2, SERPINC1, SERPINA1, VIP
18	hepatitis a	24.1	SERPINC1, LEP, CHKB, B2M, CD79A, CD40LG
19	gestational diabetes	23.6	RETN, VWF, SELE, SERPINC1, SERPINA1, NAMPT
20	diarrhea	23.5	VWF, SERPINA1, VIP, VEGFA, SCT, CFTR
21	blindness	22.3	PIK3C2A, CNR1, VWF, SELE, SELP, SERPINC1
22	purpura	21.3	VWF, SELE, SELP, SERPINC1, VEGFA, LEP
23	esophageal cancer	20.8	REG1A, CNR1, VEGFA, LPL, BCL2, LEP
24	proteinuria	20.7	PIK3C2A, VWF, SELP, SERPINC1, NAGLU, VEGFA
25	thyroid cancer	20.5	VEGFA, BCL2, BAX, B2M, MPO, CD40LG
26	ischemia	20.2	PIK3C2A, RETN, CNR1, CNR2, VWF, SELE
27	obesity	19.7	PIK3C2A, REG3A, RETN, CNR1, CNR2, VWF
28	esophagitis	19.5	PIK3C2A, REG1A, CNR1, KIAA0101, SELE, SERPINC1
29	peritonitis	19.4	PIK3C2A, REG1A, VWF, SELE, SELP, SERPINC1
30	cystic fibrosis	19.0	REG1A, REG3A, VWF, SELP, SERPINC1, SERPINA1
31	carcinoma	18.4	PIK3C2A, REG1A, REG3A, RETN, CNR1, CNR2
32	prostatitis	17.7	PIK3C2A, RETN, CNR1, CNR2, VWF, SELE
33	fibrosis	17.7	REG1A, REG3A, RETN, CNR1, CNR2, VWF
34	diabetes mellitus	17.7	PIK3C2A, REG1A, RETN, CNR1, CNR2, VWF
35	cholesterol	17.0	PIK3C2A, REG1A, RETN, CNR1, CNR2, VWF
36	thyroiditis	15.5	PIK3C2A, RETN, CNR2, KIAA0101, VWF, SELE
37	pancreatic diseases	15.1	REG1A, REG3A, NAGLU, CLPS, SCT, CFTR
38	steatorrhea	14.7	LPL, CLPS, SCT, CFTR, APOC2, CCK
39	alcoholic pancreatitis	14.6	SCT, CFTR, CCK, ALDH2, CYP2E1, SPINK1
40	exocrine pancreatic insufficiency	14.5	CLPS, SCT, CFTR, CEL, CD79A, CCK
41	gastrointestinal system disease	14.3	SCT, MIF, CCK, CCKAR, GHRL, TACR1
42	primary sclerosing cholangitis	14.3	BPI, CFTR, MPO, GPT, ELANE, PRTN3
43	chronic infantile neurological cutaneous articular syndrome	14.3	IL18, IL1B, IL1R1, IL1RAPL2, IL1RN, CASP1
44	adult-onset still's disease	14.2	IL18, IL1R1, IL1RAPL2, IL6, CRP
45	tropical calcific pancreatitis	14.2	REG1A, CFTR, SPINK1, CTSB, ACE, PRSS2
46	hereditary pancreatitis	14.2	REG1A, CFTR, SPINK1, CTSB, PRSS1
47	creatine phosphokinase	14.2	PIK3C2A, CHKB, MB, GPT, ALPP, SOD1
48	dengue disease	14.2	PIK3C2A, CD40LG, CCL4, CCL5, SULT1A3, PLA2G2A
49	obstructive jaundice	14.2	LCAT, CCK, GPT, ALPP, TTR, PSG2
50	muckle-wells syndrome	14.2	IL1B, IL1R1, IL1RAPL2, IL8, CASP1, CRP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to acute pancreatitis:

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MGI Mouse Phenotypes related to acute pancreatitis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.6	SELP, LPL, CFTR, CD14, MGP, APOE
2	endocrine/exocrine gland phenotype	MP:0005379	10.2	REG1A, XDH, CD40LG, FGFR1, IL2, IL22
3	hematopoietic system phenotype	MP:0005397	10.0	KIAA0101, BNIP3L, BCL2, LCN2, IRAK4, MIF
4	liver/biliary system phenotype	MP:0005370	9.8	RETN, SERPINC1, SERPINA6, VEGFA, LPL, LCAT
5	embryogenesis phenotype	MP:0005380	9.7	SERPINC1, FGFR1, IL5, MB, GPX4, F2
6	immune system phenotype	MP:0005387	9.6	CNR2, KIAA0101, VWF, SELP, SERPINA6, NAGLU
7	renal/urinary system phenotype	MP:0005367	8.9	SELP, SERPINA6, NAGLU, BCL2, LCAT, BAX
8	no phenotypic analysis	MP:0003012	8.8	CNR1, SERPINA6, VEGFA, CD79A, INS, FGFR1
9	integument phenotype	MP:0010771	8.7	CNR1, CNR2, SELP, CLPS, BCL2, XDH
10	behavior/neurological phenotype	MP:0005386	8.7	CNR1, SELE, SELP, SERPINA6, VIP, NAGLU
11	mortality/aging	MP:0010768	8.4	PIK3C2A, CNR1, VWF, SELE, SELP, SERPINC1
12	nervous system phenotype	MP:0003631	8.2	CNR1, VWF, SELP, SERPINC1, NAGLU, SCT
13	reproductive system phenotype	MP:0005389	8.0	REG1A, VIP, VEGFA, LEP, B2M, MMP9
14	normal phenotype	MP:0002873	7.8	SELE, VIP, VEGFA, SAT1, CFTR, CD79A
15	skeleton phenotype	MP:0005390	7.6	CNR1, NAGLU, VEGFA, LEP, BAX, CD14
16	adipose tissue phenotype	MP:0005375	7.6	PIK3C2A, RETN, CNR1, LPL, CLPS, BCL2
17	digestive/alimentary phenotype	MP:0005381	7.0	VWF, VEGFA, CLPS, BCL2, LEP, B2M
18	growth/size phenotype	MP:0005378	6.9	PIK3C2A, CNR1, SELE, SELP, NAGLU, LPL
19	tumorigenesis	MP:0002006	6.4	BCL2, LEP, SAT1, B2M, MMP2, MMP9
20	muscle phenotype	MP:0005369	6.4	VEGFA, LPL, BNIP3L, BCL2, LEP, CHKB
21	vision/eye phenotype	MP:0005391	6.3	SELE, SELP, SERPINC1, NAGLU, VEGFA, BCL2
22	cellular phenotype	MP:0005384	4.3	CNR1, KIAA0101, VWF, SELE, SELP, NAGLU
23	cardiovascular system phenotype	MP:0005385	4.2	VWF, SELE, SELP, SERPINC1, NAGLU, VEGFA
24	homeostasis/metabolism phenotype	MP:0005376	4.0	PIK3C2A, REG1A, REG3A, RETN, CNR1, VWF

Articles related to acute pancreatitis:

(show top 50)    (show all 497)

id	Title	Authors	Year	Affiliating Genes
1	Epidermal growth factor serum levels and the 61 G/A p olymorphism in patients with acute pancreatitis. (20127414)	Papachristou G.I.... Whitcomb D.C.	2010	EGF
2	Polymorphisms in tumour necrosis factor alpha (TNFalp ha) gene in patients with acute pancreatitis. (20396411)	Ozhan G.... Alpertunga B.	2010	TNF
3	Cross-talk between oxidative stress and pro-inflammat ory cytokines in acute pancreatitis: a key role for protein phosphatases. (19754377)	Escobar J.... Sastre J.	2009	TNF, DUSP19
4	The study of the relationship between interleukin gene polymorphism and the morbidity of patients with acute pancreatitis. (19220961)	Chen X.Q.... Chen Y.C.	2009	IL6, IL1B
5	Time frames for analysis of inflammatory mediators in acute pancreatitis: improving admission triage. (19082718)	Duarte-Rojo A.... Robles-DA-az G.	2009	REG3A
6	Thrombotic thrombocytopenic purpura associated with severe acute pancreatitis in a context of decreased ADAMTS13 activity: a case report. (18989146)	Piton G.... Capellier G.	2008	ADAMTS13
7	Genetic polymorphism of MCP-1-2518, IL-8-251 and susceptibility to acute pancreatitis: A pilot study in population of Suzhou, China. (18837094)	Chen W.C.... Nie J.S.	2008	IL8, CCL2
8	Pharmacological approach to acute pancreatitis. (18494044)	Bang U.C.... Bendtsen F.	2008	SST
9	Use of activated protein C has no avail in the early phase of acute pancreatitis. (19088933)	Akay S.... Batur Y.	2008	GSR, IL6, MPO
10	Gene polymorphisms of the macrophage migration inhibitory factor and acute pancreatitis. (17495357)	Makhija R.... Demaine A.	2007	MIF
11	The value of IL-6 in predicting the severity of acute pancreatitis. (17450041)	De Waele J.J.... Blot S.	2007	IL6
12	Alterations of Toll-like receptor 4 expression on peripheral blood monocytes during the early stage of human acute pancreatitis. (17415654)	Li H.G.... Wang Y.	2007	TLR4
13	A case of esophageal small cell carcinoma associated with hypercalcemia causing severe acute pancreatitis. (17957966)	Kanno K.... Ohira H.	2007	PTHLH
14	Serum macrophage migration inhibitory factor is an early marker of pancreatic necrosis in acute pancreatitis. (17245183)	Rahman S.H.... Guillou J.P.	2007	MIF, CD14
15	Cytokines and other immunological parameters as markers of distant organ involvement in acute pancreatitis (17394854)	MartA-n Alonso M.A.... Caro-PatA^n A.	2007	F2R, IL18, IL1RN
16	Effects of glutamine-enriched total parenteral nutrition on acute pancreatitis. (17311061)	Sahin H.... Ok E.	2007	TF, SLC17A5
17	Elevation of plasma tissue factor levels in patients with severe acute pancreatitis. (16868806)	Sawa H.... Kuroda Y.	2006	F3
18	Prognostic values of IL-6, IL-8, and IL-10 in acute pancreatitis. (16633121)	Stimac D.... PeriA8 R.	2006	IL6, IL8, IL10
19	Biochemical markers of acute pancreatitis. (16567468)	Matull W.R.... O'Donohue J.W.	2006	IL6
20	Accuracy of plasma levels of polymorphonuclear elastase as early prognostic marker of acute pancreatitis in routine clinical conditions. (16357624)	DomA-nguez-MuA+oz J.E.... Iglesias-GarcA-a J.	2006	ELANE
21	Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis. (15782101)	Tukiainen E.... Puolakkainen P.	2005	SPINK1
22	CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis. (16273622)	Chao Y.C.... Hsieh T.Y.	2005	CD14
23	Serum anti-oxidative barrier in acute pancreatitis (16161924)	Modzelewski B.	2005	SOD1
24	Lanreotide autogel is a therapeutic option for patients who develop acute pancreatitis after somatostatin analog treatment. (15717663)	Boix E.... PicA^ A.	2004	SST
25	Acute pancreatitis in the early stages of pregnancy associated with a PSTI gene mutation. (15367892)	Inoue N.... Funakoshi A.	2004	SPINK1
26	Acute pancreatitis associated with interferon and rib avirin therapy in patients with chronic hepatitis C. (15309891)	Chaudhari S.... Bini E.J.	2004	IFNA1
27	Laboratory markers of severe acute pancreatitis. (15753607)	Rau B.... Beger H.G.	2004	IL6, IL8, ELANE
28	Expression of TREM-1 mRNA in acute pancreatitis. (15309732)	Wang D.Y.... Chang Q.	2004	TREM1
29	Acute pancreatitis. (15689676)	Nagar A.B.... Gorelick F.S.	2004	TACR1
30	In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetes. (15538738)	Descamps F.J.... Opdenakker G.	2004	MMP9
31	Non-occlusive mesenteric ischemia and its associated intestinal gangrene in acute pancreatitis. (12890994)	Hirota M.... Ogawa M.	2003	PIK3C2A
32	Trypsinogen-2 and trypsinogen activation peptide (TAP) in urine of patients with acute pancreatitis. (12850473)	Lempinen M.... Kemppainen E.	2003	CRP
33	Clinical value of lipopolysaccharide-binding protein (LBP) determinations in acute pancreatitis. (12856185)	Rau B.... Beger H.G.	2003	LBP, CRP
34	Endotoxin and anti-endotoxin antibodies in the prognosis of acute pancreatitis. (12432837)	MartA-nez J.... PAcrez-Mateo M.	2002	CD40LG
35	Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome. (14561181)	Bhatia M.	2002	IL6, IL8, IL10
36	ErbB2 oncogene expression supports the acute pancreatitis-chronic pancreatitis sequence. (12404064)	Standop J.... Pour P.M.	2002	ERBB2
37	Soluble thrombomodulin plasma levels are an early indication of a lethal course in human acute pancreatitis. (11935133)	Mantke R.... Schulz H.U.	2002	CRP, SULT1A3
38	Intramucosal pH and endotoxin and cytokine release in severe acute pancreatitis. (10638674)	Hynninen M.... Takkunen O.	2000	IL6, IL8, IL10
39	Role of procalcitonin and granulocyte colony stimulating factor in the early prediction of infected necrosis in severe acute pancreatitis. (10644318)	MA1ller C.A.... BA1chler M.W.	2000	CRP
40	Serum levels of extracellular matrix in acute pancreatitis. (10626198)	Lohr M.... Liebe S.	1999	COL14A1
41	Anti-inflammatory cytokine response and clinical outcome in acute pancreatitis. (10628606)	Simovic M.O.... Windsor J.A.	1999	IL6, IL8
42	The clinical value of human pancreas-specific protein procarboxypeptidase B as an indicator of necrosis in acute pancreatitis: comparison to CRP and LDH. (9700943)	Rau B.... Beger H.G.	1998	CRP, CPB1
43	Technique and outcome of surgical therapy in acute pancreatitis (8685852)	Uhl W.... BA1chler M.W.	1996	CRP, ELANE
44	Influence of etiology on the course and outcome of acute pancreatitis. (8899793)	Uhl W.... Buchler M.W.	1996	ABCB7
45	Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. (8813775)	McKay C.J.... Baxter J.N.	1996	IL6, IL1B, IL8
46	Influence of somatostatin in the evolution of acute pancreatitis. A prospective randomized study. (7915294)	Luengo L.... Castellote J.M.	1994	SST
47	Serum levels of pancreatitis-associated protein as indicators of the course of acute pancreatitis. Multicentric Study Group on Acute Pancreatitis. (8119544)	Iovanna J.L.... Dagorn J.C.	1994	REG3A
48	Human pancreatic secretory trypsin inhibitor in the assessment of the severity of acute pancreatitis. A comparison with C-reactive protein. (7963355)	Pezzilli R.... Miglioli M.	1994	CRP
49	Reduction in circulating levels of CD4-positive lymphocytes in acute pancreatitis: relationship to endotoxin, interleukin 6 and disease severity. (7902182)	Curley P.J.... Whicher J.T.	1993	IL6, CRP
50	Alpha-fetoprotein producing carcinoma of the gallbladder associated with anomalous arrangement of the pancreaticobiliary ductal system--early detection through an attack of acute pancreatitis. (1385251)	Ikeda M.... Matsumoto Y.	1992	AFP

Genes related to acute pancreatitis according to GeneCards:

(show top 50)    (show all 209)

id	Symbol	Description	Score	GeneCards Section Context
1	CPB1	carboxypeptidase B1 (tissue)	11.1	Publications, Summaries
2	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
3	REG3A	regenerating islet-derived 3 alpha	11.0	Publications
4	PRSS2	protease, serine, 2 (trypsin 2)	11.0	Publications
5	CLPS	colipase, pancreatic	11.0	Publications
6	GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	11.0	Publications
7	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0	Publications
8	SST	somatostatin	11.0	Publications
9	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
10	SCT	secretin	11.0	Publications
11	CXCL5	chemokine (C-X-C motif) ligand 5	11.0	Publications
12	ELANE	elastase, neutrophil expressed	11.0	Publications
13	GP2	glycoprotein 2 (zymogen granule membrane)	11.0	Publications
14	CRP	C-reactive protein, pentraxin-related	11.0	Publications
15	PNLIP	pancreatic lipase	11.0	Publications
16	C1S	complement component 1, s subcomponent	11.0	Publications
17	SAT1	spermidine/spermine N1-acetyltransferase 1	11.0	Publications
18	CEL	carboxyl ester lipase (bile salt-stimulated lipase)	11.0	Publications
19	CCK	cholecystokinin	11.0	Publications
20	RETN	resistin	11.0	Publications
21	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
22	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
23	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	11.0	Publications
24	PLA2G1B	phospholipase A2, group IB (pancreas)	11.0	Publications
25	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
26	APOC2	apolipoprotein C-II	11.0	Publications
27	REG1A	regenerating islet-derived 1 alpha	11.0
28	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
29	LBP	lipopolysaccharide binding protein	11.0	Publications
30	PTAFR	platelet-activating factor receptor	11.0	Publications
31	CPA6	carboxypeptidase A6	11.0	Publications
32	IAPP	islet amyloid polypeptide	11.0	Publications
33	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	11.0	Publications
34	HRH2	histamine receptor H2	11.0	Publications
35	MPO	myeloperoxidase	11.0	Publications
36	CCKAR	cholecystokinin A receptor	11.0	Publications
37	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	11.0	Publications
38	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.0	Publications
39	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0	Publications
40	TGFB3	transforming growth factor, beta 3	11.0	Publications
41	FLNB	filamin B, beta	11.0	Publications
42	IL8	interleukin 8	11.0	Publications
43	F2RL1	coagulation factor II (thrombin) receptor-like 1	11.0	Publications
44	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
45	IL10	interleukin 10	11.0	Publications
46	TLR4	toll-like receptor 4	11.0	Publications
47	TMPRSS15	transmembrane protease, serine 15	11.0	Publications
48	CTSB	cathepsin B	11.0	Publications
49	IL1R1	interleukin 1 receptor, type I	11.0	Publications
50	CD14	CD14 molecule	11.0	Publications

Pathways related to acute pancreatitis according to GeneDecks:

(show top 50)    (show all 97)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	11.0	CFTR, LBP, IRAK4, IL1R1, DEFB4A, TLR2
2	Immune response_Bacterial infections in normal airways41	10.7	NOS2, LBP, CFTR, CD14, IRAK4, IL1B
3	RAR-Gamma-RXR-Alpha Degradation36	10.6	CXCL5, TGFB3, TBP, CCL5, CCL4, IL22
4	IL-6 Pathway36	10.3	BAX, IL10, IL11, IL18, IL22, IL5
5	Amoebiasis20	10.2	TGFB3, TGFB1, TLR4, TLR2, NOS2, IL8
6	Akt Signaling36	10.2	IL11, IL10, FGFR1, FGF1, ITGB2, ITGAM
7	Pertussis20	10.0	CXCL5, TLR4, C1S, RHOA, NFKB1, NOS2
8	Immune response MIF in innate immunity response10	9.8	TNF, CD14, NFKB1, TLR4, NOS2, PTGS2
9	Endothelin-1 Signaling Pathway36	9.8	IL18, CXCL5, IL1A, IL1B, IL2, IL22
10	Immune response_MIF in innate immunity response41	9.8	IRAK4, IL8, TLR4, NFKB1, NOS2, TNF
11	Influenza A20	9.8	IFNA1, ACTG1, NFKB1, TNF, CASP1, HSPA1B
12	Malaria20	9.7	HGF, TGFB3, TGFB1, TLR4, TLR2, TNF
13	Regulation of eIF4 and p70S6K36	9.6	EGF, IL11, FGF1, ITGB2, ITGAM, BAX
14	Complement and coagulation cascades20	9.6	KNG1, PROC, PROS1, KLKB1, VWF, SERPINC1
15	Cytokine Network36	9.6	IFNA1, IL8, IL6, IL5, IL2, IL1B
16	Rheumatoid arthritis20	9.4	CXCL5, IL1B, IL1A, IL18, IL11, ITGB2
17	Chagas disease (American trypanosomiasis)20	9.3	IRAK4, IL10, TGFBR1, TGFB3, TGFB1, TLR4
18	PGC1Alpha Pathway36	9.3	PPARA, CCL5, CCL4, IL8, IL5, IL22
19	Immune response IL-1 signaling pathway10	9.3	NOS2, IL6, TNF, F3, NFKB1, EDN1
20	NFAT Signaling and Lymphocyte Interactions36	9.2	IL2, IL22, IL1A, IL5, BAX, CCL4
21	Immune response_IL-1 signaling pathway41	9.2	IL6, F3, TNF, PTGS2, NOS2, NFKB1
22	STAT3 Pathway36	9.2	HGF, CXCL5, TGFB3, TNF, CCL5, IL1A
23	Immune response_MIF-mediated glucocorticoid regulation41	9.1	NFKB1, NOS2, NR3C1, PTGS2, TNF, ICAM1
24	Toxoplasmosis20	9.1	CD40LG, BCL2, IRAK4, IL10, PLA2G6, HSPA1A
25	Immune response MIF-mediated glucocorticoid regulation10	9.0	MIF, IL2, NFKB1, IL6, IL8, ICAM1
26	Leishmaniasis20	8.9	ITGAM, TGFB1, TGFB3, NOS2, IL1B, TLR4
27	all-trans-Retinoic Acid Signaling in Brain36	8.9	IL5, IL6, IL8, CCL4, CCL2, CCL5
28	PEDF Induced Signaling36	8.8	NFKB1, TNF, CCL5, CCL2, CCL4, IL8
29	NF-KappaB Family Pathway36	8.7	NFKB1, EGF, TNF, IL6, IL1R2, IL1R1
30	NF-KappaB (p50-p65) Pathway36	8.7	GAS6, IL1B, HGF, TGFB3, TLR2, TNF
31	MAPK signaling pathway20	8.6	CASP3, TNF, PLA2G1B, PLA2G6, IL1B, PLA2G2A
32	MIF Regulation of Innate Immune Cells36	8.6	TNF, CCL5, CCL2, CCL4, IL8, IL6
33	DHA Signaling36	8.5	IL6, IL2RA, CASP3, IL1B, FGFR1, BAX
34	ERK Signaling36	8.5	CXCL5, IL1B, IL2, IL22, IL5, IL18
35	MIF Mediated Glucocorticoid Regulation36	8.5	BCL2, BAX, CD14, CXCL5, CCL4, CCL5
36	PAK Pathway36	8.4	TIMP1, ACTG1, TNF, CASP1, CASP3, CCL5
37	Molecular Mechanisms of Cancer36	8.4	CCR1, IL6, IL5, IL22, IL2, IL1R1
38	Tuberculosis20	8.4	IRAK4, ITGB2, ITGAM, CD14, LBP, BAX
39	TGF-Beta Pathway36	8.3	GAS6, HGF, TGFBR1, TGFB3, TGFB1, TIMP1
40	SOCS Pathway36	8.3	INS, IL6, CCL5, IL2, IL1B, IL1A
41	Glucocorticoid Receptor Signaling36	8.3	TGFB1, NFKB1, NR3C1, TBP, HSPA1B, HSPA1A
42	Cytokine-cytokine receptor interaction20	8.3	IL8, IL10, CD40LG, LEP, VEGFA, IL11
43	Antioxidant Action of Vitamin-C36	8.0	BCL2, BAX, FLNB, TNF, PLA2G1B, PLA2G6
44	Rho Family GTPases36	7.9	GAS6, HGF, CXCL5, TGFB3, TGFB1, TIMP1
45	MAPK Family Pathway36	7.8	IL22, BCL2, BAX, IL2, IL1R1, IL1B
46	MAPK Signaling36	7.5	HSF1, TGFB3, ERBB2, TNF, COL14A1, TGFBR1
47	Tec Kinases Signaling36	7.5	TLR4, IL6, IL5, IL2RA, IL22, IL2
48	p38 Signaling36	7.3	BAX, BCL2, IRAK4, GAS6, HGF, CXCL5
49	Pathways in cancer20	7.1	BAX, BCL2, CASP3, HGF, MMP2, MMP9
50	JAK-STAT Pathway36	7.1	GAS6, HGF, TGFB3, TGFB1, TIMP1, EGF

Compounds related to acute pancreatitis according to GeneDecks:

(show top 50)    (show all 544)

id	Compound	Score	Top Affiliating Genes
1	nicotine32 34 9 9	13.8	GPT, PTHLH, CYP2E1, SLC17A5
2	estradiol32 9 18 9	13.7	SERPINA6, CHKB, P4HB, IL11, IL18, IL1R1
3	dopamine32 9 18 9	13.5	SELE, VIP, NAGLU, SCT, CHKB, P4HB
4	forskolin32 42 9 9	13.3	RETN, CNR2, VIP, SCT, CFTR, CES1
5	nmda32 42	11.2	CNR1, LEP, P4HB, GSR, FGF1, IL1A
6	ccl432	10.0	IL1R1, CCL4, CCL2, CCR1, CCL5, GPT
7	phospholipid32	10.0	VWF, SERPINA1, LPL, BPI, CLPS, SCT
8	manganese superoxide32	9.9	CD14, GSR, GSTM1, GSTP1, GSTT1, IL1A
9	latex32	9.9	VWF, NAGLU, CHKB, CEL, CD14, ITGAM
10	polyinosinic-polycytidylic acid32	9.9	SELE, IL10, IL18, IL2, IL5, IL6
11	fluticasone propionate32 42 9 9	12.8	SELE, SERPINA6, MPO, MMP9, IL1B, IL5
12	pge132	9.8	PIK3C2A, VWF, VIP, LCAT, B2M, IL11
13	guanidine hydrochloride32	9.7	VWF, LPL, CHKB, P4HB, FN1, GSR
14	gold sodium thiomalate32	9.7	SELE, NAGLU, CD14, IL1A, IL1B, IL1R1
15	nitric oxide32 9 18 9	12.7	RETN, SELE, SELP, SERPINA4, SERPINA1, NAGLU
16	carbon32	9.6	CNR1, CNR2, VWF, LPL, CEL, MMP2
17	gf 109203x32 42	10.6	VEGFA, CFTR, FN1, MIF, CCL5, F2RL1
18	erythromycin32 9 9	11.4	PIK3C2A, VIP, MPO, CD40LG, ITGB2, MMP2
19	guanine32 9 18 9	12.4	CNR1, VWF, SELE, VIP, LPL, SCT
20	aprotinin32 9 9	11.3	VWF, SELP, SERPINC1, SERPINA4, VIP, NAGLU
21	ribonucleic acid32	9.1	SERPINA6, NAMPT, MMP2, MMP9, FGF1, FGFR1
22	adenylate32	9.0	CNR1, CNR2, VWF, SELE, SELP, SERPINC1
23	quercetin32 42 9 18 9	12.9	PIK3C2A, SELE, BCL2, BAX, XDH, CFTR
24	ribavirin32 34 9 9	11.9	LEP, CD40LG, MMP2, MMP9, IL10, IL18
25	dextran sulfate32	8.9	SELE, SELP, SERPINC1, LPL, MPO, CD40LG
26	captopril32 42 9 9	11.9	VIP, B2M, CD79A, MMP2, IL1A, F3
27	matrigel32	8.9	VWF, SELE, SERPINA4, VEGFA, MMP2, MMP9
28	rantes32	8.8	SELE, SELP, VIP, SCT, CD14, CD40LG
29	ibmx32	8.8	VIP, LPL, SCT, CFTR, ITGB2, MMP2
30	lipid32	8.8	PIK3C2A, RETN, CNR1, CNR2, SELE, SERPINA6
31	fluorescein32 9 9	10.8	SERPINC1, VEGFA, MPO, CD40LG, ITGAM, MMP2
32	homocysteine32 18	9.8	PIK3C2A, RETN, VWF, SELE, SELP, SERPINC1
33	uric acid32 18	9.8	PIK3C2A, RETN, NAGLU, LEP, CHKB, XDH
34	histamine32 18	9.7	CNR1, VWF, SELE, SELP, VIP, SCT
35	n acetylcysteine32	8.7	VWF, SELE, SELP, SERPINC1, NAGLU, CFTR
36	atorvastatin32 34 9 18 9	12.6	PIK3C2A, RETN, VWF, SELE, SELP, VEGFA
37	butyrate32	8.3	BCL2, LEP, LCAT, BAX, B2M, CFTR
38	sb 20358032 42	9.2	SELE, VEGFA, BCL2, SAT1, ITGAM, ITGB2
39	simvastatin32 34 42 9 18 9	13.2	PIK3C2A, VWF, SELE, SELP, VEGFA, LPL
40	tetracycline32 9 9	10.1	VWF, SAT1, CD40LG, MMP2, MMP9, MIF
41	tacrolimus32 34 9 9	11.0	NAGLU, CHKB, CD79A, FN1, INS, IL10
42	herbimycin a32 42	8.7	SELE, CD14, CD40LG, ITGB2, MMP2, MMP9
43	5fluorouracil32	7.7	SELE, VEGFA, BCL2, BAX, SAT1, CES1
44	wortmannin32 42	8.4	PIK3C2A, BCL2, LEP, BAX, CD14, ITGAM
45	estrogen32	7.3	RETN, VWF, SERPINC1, SERPINA6, SERPINA1, VIP
46	folate32	6.8	VWF, SELE, SERPINC1, B2M, CD79A, CD40LG
47	paraffin32	6.6	VWF, SERPINA1, VEGFA, BCL2, LEP, CHKB
48	cisplatin32 34 9 9	9.2	PIK3C2A, CNR2, NAGLU, VEGFA, BCL2, LEP
49	genistein32 9 18 9	8.9	REG1A, SELE, SELP, VEGFA, LPL, BCL2
50	actinomycin d32	5.5	RETN, SELE, VEGFA, BPI, BCL2, BAX

Cellular components related to acute pancreatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	10.2	AHSG, TGFB3, PRSS2, PRTN3, SOD1, COL14A1
2	cell surface	GO:009986	9.3	GHSR, HMGB1, TNF, ELANE, TLR2, TGFB1
3	external side of plasma membrane	GO:009897	9.3	TNF, PTPRC, CTSB, ACE, TLR2, TLR4
4	secretory granule	GO:030141	8.9	TF, ELANE, PLA2G2A, PLA2G1B, GHRL, HSPD1
5	plasma membrane	GO:005886	8.1	ERBB2, TREM1, TNF, PTAFR, PTPRC, RHOA
6	platelet alpha granule lumen	GO:031093	7.6	GAS6, SERPINA1, VWF, VEGFA, FN1, HGF
7	extracellular region	GO:005576	5.9	F5, IL22, IL2, IL1R2, IL1R1, IL1B
8	extracellular space	GO:005615	5.2	CALCA, MBL2, APOH, APOE, APOC2, IL8

Biological processes related to acute pancreatitis according to GeneDecks:

(show top 50)    (show all 56)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of sensory perception of pain	GO:051930	10.7	IL10, IL1A, CCK, F2R, EDN1, TLR4
2	negative regulation of tumor necrosis factor production	GO:032720	10.7	GAS6, ADIPOQ, TLR4, HSF1, IL10, GSTP1
3	cellular response to lipopolysaccharide	GO:071222	10.6	TLR4, NOS2, ICAM1, CCL2, IL8, IL10
4	positive regulation of chemokine production	GO:032722	10.6	TLR4, TLR2, TNF, IL6, IL18, LBP
5	extracellular matrix disassembly	GO:022617	10.5	PRSS1, PRSS2, TIMP1, ELANE, KLKB1, CTRB2
6	negative regulation of growth of symbiont in host	GO:044130	10.5	IL10, MBL2, TNF, ELANE, TLR2, LBP
7	positive regulation of interleukin-8 production	GO:032757	10.5	ADIPOQ, LBP, IL18, IL1B, CALCA, TLR2
8	immune response	GO:006955	10.4	PTAFR, HRH2, IGHE, CCR1, LTB, TLR2
9	leukocyte cell-cell adhesion	GO:007159	10.4	PTPRC, CALCA, ICAM1, CCL5, ITGB2, CD40LG
10	innate immune response	GO:045087	10.4	TXN, CTSB, NFKB1, C1S, AGER, TLR2
11	leukocyte migration	GO:050900	10.4	TREM1, ELANE, PROS1, PROC, GAS6, F2RL1
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.3	TNF, EDNRA, TLR4, GAS6, F2RL1, F2R
13	positive regulation of interleukin-6 production	GO:032755	10.3	TLR4, TLR2, TNF, HSPD1, IL6, IL1B
14	elevation of cytosolic calcium ion concentration	GO:007204	10.2	GHRL, EDN1, EDNRA, TACR1, KNG1, GLP1R
15	response to heat	GO:009408	10.2	CALCA, SST, TACR1, SOD1, HSF1, CCKAR
16	extracellular matrix organization	GO:030198	10.2	KLKB1, ELANE, TIMP1, PRSS2, PRSS1, COL14A1
17	proteolysis	GO:006508	10.1	ELANE, PROS1, PRSS2, PRSS1, PRTN3, PROC
18	response to glucocorticoid stimulus	GO:051384	10.1	CCL5, HMGB1, TNF, PTGS2, ADIPOQ, CCKAR
19	B cell proliferation	GO:042100	10.1	PTPRC, HSPD1, IL10, CD40LG, CD79A, BCL2
20	lipopolysaccharide-mediated signaling pathway	GO:031663	10.0	TGFB1, TLR4, TLR2, TNF, CCL5, CCL2
21	acute-phase response	GO:006953	10.0	IL6, MBL2, F2, CRP, AHSG, IL22
22	positive regulation of cytokine secretion	GO:050715	9.9	TLR2, TNF, CADM1, IL1A, IL10, INS
23	response to lipopolysaccharide	GO:032496	9.9	CNR2, SELE, SELP, SERPINA1, LBP, MMP9
24	response to toxin	GO:009636	9.9	PON1, TLR4, CASP1, CCL5, CCL4, MPST
25	response to ethanol	GO:045471	9.9	ADIPOQ, SOD1, TACR1, TLR4, CTSB, ICAM1
26	positive regulation of fever generation	GO:031622	9.7	PTGS2, TNF, CCL5, IL1B, CNR1
27	cell-cell signaling	GO:007267	9.7	CCL5, IAPP, CALCA, TXN, PTHLH, SST
28	aging	GO:007568	9.7	TGFB3, TGFB1, TIMP1, EDNRA, NR3C1, CALCA
29	lipid metabolic process	GO:006629	9.6	PNLIP, PPARA, ALB, APOE, APOC2, IL1RN
30	response to wounding	GO:009611	9.5	TGFB1, AGER, CTSB, CASP3, F2R, F2
31	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.5	HGF, CAT, F2RL1, F2R, F2, CCL5
32	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	HGF, ADIPOQ, TLR4, CCK, IL6, IL5
33	response to radiation	GO:009314	9.3	TGFB1, NR3C1, TXN, CCKAR, IL18, MMP9
34	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	TLR4, TLR2, EDN1, PTGS2, TNF, ICAM1
35	response to copper ion	GO:046688	9.2	SOD1, NFKB1, ICAM1, IL1A, LCAT, BCL2
36	response to drug	GO:042493	9.2	TNF, PTGS2, SST, EDN1, ABP1, TGFB1
37	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.2	GAS6, TGFB1, TNF, IL6, IL11, MIF
38	positive regulation of MAP kinase activity	GO:043406	9.0	TGFB1, ELANE, EGF, EDN1, TNF, ERBB2
39	positive regulation of apoptotic process	GO:043065	9.0	KNG1, SOD1, TLR4, PTPRC, PTGS2, TNF
40	inflammatory response	GO:006954	8.9	CNR2, F2RL1, CALCA, TNF, PTGS2, PTAFR
41	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.9	NFKB1, AGER, TLR2, TLR4, TGFB1, PLA2G1B
42	small molecule metabolic process	GO:044281	8.7	CYP2E1, PTGS2, TXN, GLP1R, CAT, ALDH2
43	positive regulation of protein phosphorylation	GO:001934	8.6	GAS6, ADIPOQ, TGFB1, EDNRA, TNF, ERBB2
44	anti-apoptosis	GO:006916	8.5	F3, HSPA1B, GHRL, TNF, NR3C1, NFKB1
45	positive regulation of cell proliferation	GO:008284	8.1	EDN1, PTHLH, GLP1R, F2R, EDNRA, EGF
46	response to hypoxia	GO:001666	8.0	IL1A, IL1B, MB, ENG, CCL2, CAT
47	platelet degranulation	GO:002576	7.8	GAS6, HGF, VWF, SELP, SERPINA1, VEGFA
48	negative regulation of apoptotic process	GO:043066	7.7	CASP3, CAT, GLP1R, GHRL, TNF, EDNRA
49	platelet activation	GO:030168	7.4	ALB, RHOA, A2M, EGF, TIMP1, TGFB1
50	blood coagulation	GO:007596	7.2	VWF, SELP, SERPINC1, SERPINA1, VEGFA, PROS1

Molecular functions related to acute pancreatitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide binding	GO:001530	10.2	TLR4, PTAFR, HSPD1, CD14, LBP, BPI
2	serine-type endopeptidase activity	GO:004252	10.2	ELANE, PRSS2, PRSS1, PRTN3, PROC, HGF
3	cell surface binding	GO:043498	9.9	HSPD1, F3, ICAM1, MIF, LBP, VEGFA
4	hormone activity	GO:005179	9.8	PTHLH, SST, EDN1, TTR, ADIPOQ, CALCA
5	receptor binding	GO:005102	9.7	CAT, CALCA, PLA2G1B, NOS2, LTB, KNG1
6	heparin binding	GO:008201	9.5	APOH, CCL2, CCL5, PTPRC, ABP1, ELANE
7	protease binding	GO:002020	9.2	RYR1, ELANE, TNF, HSPA1B, F3, IL1R1
8	cytokine activity	GO:005125	9.1	IL5, IL6, CCL4, HMGB1, TNF, LTB
9	growth factor activity	GO:008083	8.1	IL6, F2, EGF, TGFB1, TGFB3, HGF
10	protein homodimerization activity	GO:042803	6.8	PTGS2, NR3C1, CRP, NOS2, NFKB1, ABP1
11	protein binding	GO:005515	3.2	HSF1, SPINK1, CTSB, PPARA, NR3C1, CRP