MCID: ACT027
MIFTS: 63

Acute Pancreatitis malady

Gastrointestinal diseases, Endocrine diseases categories

Summaries for Acute Pancreatitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

MalaCards: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to pancreatitis and hepatitis. An important gene associated with Acute Pancreatitis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways are Transcriptional misregulation in cancer and Pancreatic secretion. The compounds lipid and testosterone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Acute Pancreatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

acute pancreatitis 8 10 44 60
pancreatitis, acute necrotizing 60
acute necrotizing pancreatitis 8
acute pancreatitis unspecified 8
pancreatitis necrotizing 8
necrotizing pancreatitis 44
acute pancreatitis nos 8


External Ids:

Disease Ontology8 DOID:2913
ICD9CM27 577.0
ICD1025 K85

Related Diseases for Acute Pancreatitis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pancreatitis, Chronic family:

acute pancreatitis Pancreatitis
Autoimmune Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 386)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.2ELANE, CPB1, SPINK1, SULT1A3, CFTR, PLA2G1B
2hepatitis30.8IL18
3recurrent acute pancreatitis30.7SPINK1, CFTR, SCT
4alcoholic pancreatitis30.6CFTR, SPINK1, CPB1, ELANE, CCK, SCT
5peritonitis30.5IL6, CRP, MPO
6pancreatic cancer30.5SCT, SPINK1, SST, CCK
7cystic fibrosis30.5IL8, CFTR, SPINK1, ELANE, REG3A, MPO
8obesity30.5CRP, RETN, CLPS, IL18, CCK, SULT1A3
9cholangitis30.5CFTR
10hyperparathyroidism30.4SCT
11diabetes mellitus30.4SPINK1, IL6, RETN, SST, CRP, SCT
12adenoma30.4SCT, SST, SPINK1
13hypertension30.4RETN, CRP
14cholecystitis30.4CCK
15acute myocardial infarction30.3CRP, RETN, SULT1A3
16myocardial infarction30.3CRP, RETN, SULT1A3
17hypercalcemia30.3SCT, SPINK1
18neuroendocrine tumor30.3SST, SCT, CCK
19acute leukemia30.3MPO, RETN
20leukemia30.3IL6, MPO, CFTR
21systemic lupus erythematosus30.3CRP, IL6, IL18, MPO, SULT1A3
22ischemia30.3PLA2G1B, MPO
23ulcerative colitis30.3CRP
24lupus erythematosus30.3IL18
25mediastinitis30.3CRP
26type 2 diabetes mellitus30.2APOC2, IL6, RETN, SPINK1, CRP, SCT
27hepatocellular carcinoma30.2ELANE, IL6, SPINK1, REG3A, SCT
28wegener's granulomatosis30.2ELANE, MPO
29disseminated intravascular coagulation30.2ELANE
30neutropenia30.1MPO, ELANE
31prostate cancer30.1SPINK1, IL6
32arthritis30.0PLA2G1B, SULT1A3, IL8, MPO, IL6, CRP
33liver cirrhosis30.0SCT, RETN
34glomerulonephritis30.0ELANE, MPO
35graves' disease30.0MPO
36rheumatoid arthritis29.8IL18, IL8, IL6, RETN, PRSS2, MPO
37inflammatory bowel disease29.8CRP, SCT, MPO, REG3A, RETN, IL18
38pancreas disease29.8CCK, SPINK1, ELANE, CFTR, CLPS, REG3A
39pneumonia29.8CRP, IL8, IL6, MPO, ELANE, CFTR
40steatorrhea29.8CCK, SST, CLPS, CFTR, SCT, ELANE
41hyperglycemia29.8SST, CRP, SCT, CCK, RETN
42duodenal ulcer29.8CCK, SCT, SST, IL8
43peptic ulcer29.8CCK, SST, SCT, IL8
44colorectal cancer29.8CCK, SPINK1, REG3A, PRSS2
45adult respiratory distress syndrome29.8IL6, MPO, ELANE, IL8
46gastritis29.8CCK, SCT, IL8, SST
47diarrhea29.8CRP, SST, CFTR
48acromegaly29.8CCK, SST, RETN
49proteinuria29.8CFTR, MPO, CRP, APOC2
50breast cancer29.8SULT1A3, CFTR

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to acute pancreatitis

Clinical Features for Acute Pancreatitis

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Drugs & Therapeutics for Acute Pancreatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Pancreatitis

Drug clinical trials:

Search ClinicalTrials for Acute Pancreatitis

Search NIH Clinical Center for Acute Pancreatitis

Search CenterWatch for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

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Anatomical Context for Acute Pancreatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Acute Pancreatitis:

32
Pancreas, Lung, Liver, Testes, Monocytes, Kidney, Endothelial, T cells, Myeloid, Spleen, Colon, Pancreatic islet, B cells, Breast, Bone, Smooth muscle, Heart, Pituitary, Prostate, Skin, Salivary gland, Thyroid, Thymus, Lymph node, Bone marrow

Animal Models for Acute Pancreatitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Pancreatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3ELANE, CCK, SCT, CRP, MPO, SST
2MP:000538711.1MPO, SST, IL18, IL8, IL6, CFTR
3MP:000538110.5CLPS, IL6, PLA2G1B, CFTR, SPINK1

Publications for Acute Pancreatitis

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Sources:
50PubMed
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Articles related to Acute Pancreatitis:

(show top 50)    (show all 1654)
idTitleAuthorsYear
1
Free radicals and acute pancreatitis: much ado about a8 (23895210)
something.
2
Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis. (24002755)
2014
3
Images of the month: A rare extrapancreatic manifestation of acute pancreatitis, and a rare presentation of a pancreatic neuroendocrine tumor. (24192943)
2013
4
The incidence of acute pancreatitis: impact of social deprivation, alcohol consumption, seasonal and demographic factors. (23859492)
2013
5
Amino acid transporters expression in acinar cells is changed during acute pancreatitis. (24075511)
2013
6
Early prognostic evaluation of acute pancreatitis: an on-going challenge. (23474548)
2013
7
Classification of acute pancreatitis. (23752646)
2013
8
Clinical analysis of 16 patients with acute pancreatitis in the third trimester of pregnancy. (23923092)
2013
9
Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice. (24361123)
2013
10
Modified gastrointestinal failure score for patients with severe acute pancreatitis. (23361596)
2013
11
A minimally invasive management for abdominal compartment syndrome in severe acute pancreatitis. (24353548)
2013
12
Predictors of surgery in patients with severe acute pancreatitis managed by the step-up approach. (22968079)
2013
13
Early fluid "resuscitation/therapy" in acute pancreatitis: which fluid? What rate? What parameters to gauge effectiveness? (23291660)
2013
14
Infective severe acute pancreatitis: a comparison of 99mTc-ciprofloxacin scintigraphy and computed tomography. (23946594)
2013
15
Renoprotective activity of sivelestat in severe acute pancreatitis in rats. (23935713)
2013
16
Development of Purtscher-like retinopathy after pre-eclampsia combined with acute pancreatitis. (24328012)
2013
17
Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. (21963611)
2012
18
Protective effects of alpha-pinene in mice with cerulein-induced acute pancreatitis. (22982349)
2012
19
Diastolic dysfunction, prolonged QTc interval and pericardial effusion as predictors of mortality in acute pancreatitis. (22849657)
2012
20
Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases. (23181131)
2012
21
Involvement of thrombopoietin in acinar cell necrosis in L-arginine-induced acute pancreatitis in mice. (22698803)
2012
22
Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database. (23300896)
2012
23
Early continuous veno-venous haemofiltration in the management of severe acute pancreatitis complicated with intra-abdominal hypertension: retrospective review of 10 years' experience. (23281603)
2012
24
The etiology of acute recurrent pancreatitis in children: a challenge for pediatricians. (21499205)
2011
25
Benign mesenteric lymphangioma presenting as acute pancreatitis: a case report. (20062588)
2009
26
Effect of salvia miltiorrhizae on pulmonary apoptosis of rats with severe acute pancreatitis or obstructive jaundice. (19543819)
2009
27
Ectopic mediastinal parathyroid adenoma: a cause of acute pancreatitis. (19598003)
2009
28
Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)
2007
29
Interleukin-18: a pro-inflammatory cytokine that plays an important role in acute pancreatitis. (17907957)
2007
30
Acute pancreatitis complicating typhoid fever in a 4-year-old girl. (18045312)
2007
31
Cancer of the papilla causing recurrent acute pancreatitis and mimicking a pancreatic stone. (17285500)
2007
32
Kinetics of group IB and IIA phospholipase A2 during low-volume continuous hemodiafiltration in severe acute pancreatitis. (17470210)
2007
33
Acute recurrent biliary pancreatitis associated with the ABCB4 gene mutation. (17273143)
2007
34
The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury. (18288270)
2007
35
Gallstone disease. Complications of bile-duct stones: Acute cholangitis and pancreatitis. (17127193)
2006
36
Hereditary pancreatitis--a rare differential diagnosis in patients with menstruation-associated recurrent acute pancreatitis: a case report. (15106365)
2004
37
The importance of interleukin 18, glutathione peroxidase, and selenium concentration changes in acute pancreatitis. (15185872)
2004
38
Severe acute necrotizing pancreatitis associated with lipoprotein lipase deficiency in childhood. (14523833)
2003
39
Hepatobiliary and pancreatic: Woman with acute intermittent porphyria. (12911670)
2003
40
Intestinal hypoperfusion contributes to gut barrier failure in severe acute pancreatitis. (12559182)
2003
41
Soluble thrombomodulin plasma levels are an early indication of a lethal course in human acute pancreatitis. (11935133)
2002
42
CFTR gene mutations in patients suffering from acute pancreatitis. (12218938)
2002
43
Role of cytokines and oxidative stress in the pathophysiology of acute pancreatitis: therapeutical implications. (14561185)
2002
44
Serum levels of extracellular matrix in acute pancreatitis. (10626198)
1999
45
Elevated serum creatine kinase activity in a patient with acute pancreatitis. (10622080)
1999
46
Splenic abscess as a complication of acute pancreatitis. (10999133)
1999
47
Somatostatin attenuates microcirculatory impairment in acute sodium taurocholate-induced pancreatitis. (9539654)
1998
48
A prospective study of ERCP in the investigation of the patients after acute non-alcoholic pancreatitis. (2262754)
1990
49
Cyclic AMP as a determinant of the course of acute alcoholic pancreatitis. (175517)
1975
50
Further clinical study of the effect of vagotomy on recurrent acute pancreatitis. (13118354)
1954

Genetic Variations for Acute Pancreatitis

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Expression for genes affiliated with Acute Pancreatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Pancreatitis

Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for genes affiliated with Acute Pancreatitis

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN
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Pathways related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7ELANE, IL6, IL8, MPO
210.7CPB1, CFTR, PLA2G1B, PRSS2
310.7IL6, MPO, CRP
410.7MPO, IL6, ELANE
5
Cytokine production by Th17 cells in CF (Mouse model)
10.7IL8, IL6, CFTR
6
Immune response Bacterial infections in normal airways
10.7CFTR, IL6, IL8
7
Hide members
10.7IL6, IL8, IL18
810.7IL6, IL8, IL18
910.7IL18, IL8, IL6
1010.5IL18
1110.5IL18
1210.5IL8

Compounds for genes affiliated with Acute Pancreatitis

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1lipid4411.5IL18, RETN, IL6, GP2, PLA2G1B, SULT1A3
2testosterone44 59 11 2414.5CCK, SCT, CRP, RETN, IL18, CFTR
3acetylcholine44 49 28 11 2415.4MPO, ELANE, CRP, CCK, SCT, SST
4retinoic acid44 2412.4SCT, CFTR, ELANE, IL6, IL18, MPO
5lactate4411.4ELANE, IL6, IL18, SST, MPO, CRP
6creatinine4411.4MPO, APOC2, CRP, SPINK1, SULT1A3, IL6
7trypsinogen4411.4CFTR, ELANE, SPINK1, REG3A, PRSS2, SCT
8cholesterol44 28 11 2414.4CLPS, CCK, APOC2, CRP, RETN, IL6
9epinephrine44 11 2413.4ELANE, SCT, SST, SULT1A3, CFTR, IL18
10histamine44 28 2413.3CCK, MPO, SST, IL18, IL8, IL6
11dexamethasone44 49 28 1114.3CFTR, RETN, IL6, PLA2G1B, CCK, SULT1A3
12isoproterenol44 1112.3ELANE, SST, SCT, RETN, IL18, CFTR
13aspirin44 49 28 2414.3ELANE, CCK, CRP, IL18, CFTR, SULT1A3
14norepinephrine44 11 2413.3CCK, RETN, CFTR, SULT1A3, ELANE
15cerulein4411.3ELANE, IL6, SCT, CCK, MPO
168-isoprostane4411.2CRP, MPO, RETN, IL8, IL6
17c-peptide4411.2SST, RETN, SCT, CRP, CCK
18neopterin4411.2IL18, IL8, IL6, ELANE, CRP
19n acetylcysteine4411.2CRP, MPO, IL6, CFTR, IL18, IL8
20taurodeoxycholate4411.2SCT, CLPS, SST, CCK
21leukotriene b444 59 2413.1ELANE, PLA2G1B, MPO, IL6, IL8
22octreotide44 59 28 1114.1SCT, CCK, MPO, SST
23homocysteine44 2412.1SULT1A3, IL18, RETN, CRP, APOC2
24cysteine4411.1CFTR, IL8, IL18, RETN, PRSS2, ELANE
25cyclosporin a44 28 5913.1CFTR, CCK, ELANE, SCT
26fibrinogen4411.1SULT1A3, ELANE, IL6, IL18, CRP, RETN
27glucose4411.1CCK, SCT, REG3A, APOC2
28aspartate4411.1RETN, SCT, CFTR, SULT1A3, CLPS
29pentoxifylline44 1112.1IL18, MPO, ELANE
30anaphylatoxin4411.1MPO, IL8, IL6, ELANE
31omeprazole44 28 49 11 2415.1CRP, CCK, SCT, SST
32gabexate mesilate4411.1SST, ELANE
33endotoxin4411.0RETN, PLA2G1B
34sivelestat4411.0ELANE, IL8, IL6
35ulinastatin4411.0ELANE, MPO
36etanercept44 49 1113.0IL8, CRP, IL18, IL6
37pge24411.0SST
38nafamostat mesilate4411.0IL18, MPO, ELANE
39curcumin4411.0SULT1A3, CFTR, IL18, IL8, IL6
40rebamipide4411.0IL6, IL8, MPO
41indomethacin44 59 28 1114.0SCT, CFTR, PLA2G1B
42loxiglumide4410.9SCT, SST, CCK
43cilomilast4410.9IL8, MPO, ELANE
44anakinra44 1111.9CRP, IL6, IL18
45serine4410.9MPO, SPINK1, IL8, IL18, SCT, APOC2
46taurine chloramine4410.8IL6, IL8, MPO
47vitamin a44 11 2412.8APOC2, RETN, ELANE, IL18, CRP
48glutamine4410.8CFTR, ELANE, IL18, CRP, SCT, CCK
49azithromycin44 1111.7CFTR, CRP, IL8
50vegf4410.6IL8, IL6, SST, IL18, RETN, MPO

GO Terms for genes affiliated with Acute Pancreatitis

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Sources:
16Gene Ontology
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Cellular components related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4ELANE, CCK, APOC2, SCT, CRP, PRSS2
2extracellular spaceGO:00561511.0CCK, APOC2, CRP, MPO, PRSS2, SST
3secretory granuleGO:03014110.7ELANE, PLA2G1B, MPO

Biological processes related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00695310.8IL6, REG3A, CRP
2negative regulation of chemokine biosynthetic processGO:04507910.8ELANE, IL6
3inflammatory responseGO:00695410.7IL6, IL8, IL18, CRP
4response to yeastGO:00187810.7MPO, ELANE
5neutrophil mediated immunityGO:00244610.7PLA2G1B, IL6
6positive regulation of immune responseGO:05077810.6PLA2G1B, ELANE
7negative regulation of lipid storageGO:01088810.5CRP, IL6
8response to drugGO:04249310.4APOC2, SST, IL6, CFTR

Molecular functions related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.7RETN, SST, SCT, CCK

Products for genes affiliated with Acute Pancreatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Pancreatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet