MCID: ACT027
MIFTS: 63

Acute Pancreatitis malady

Genetic diseases, Gastrointestinal diseases, Endocrine diseases, Rare diseases, Skin diseases, Bone diseases, Immune diseases categories

Summaries for Acute Pancreatitis

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Wikipedia:65 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

MalaCards based summary: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to pancreatitis and recurrent acute pancreatitis. An important gene associated with Acute Pancreatitis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways is Peptide ligand-binding receptors. The compounds epft and loxiglumide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and neutrophil, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Aliases & Classifications for Acute Pancreatitis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 29ICD9CM, 27ICD10
See all sources

Acute Pancreatitis, Aliases & Descriptions:

Name: Acute Pancreatitis 10 12 45 62
Pancreatitis, Acute Necrotizing 62
Acute Necrotizing Pancreatitis 10
Acute Pancreatitis Unspecified 10
 
Pancreatitis Necrotizing 10
Necrotizing Pancreatitis 45
Acute Pancreatitis Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:2913
ICD9CM29 577.0
ICD1027 K85

Related Diseases for Acute Pancreatitis

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Diseases in the Pancreatitis family:

Pancreatitis, Hereditary acute pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 328)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.0ELANE, CLPS, SULT1A3, MPO, SCT, CFTR
2recurrent acute pancreatitis31.6SPINK1, CFTR, SCT
3obstructive jaundice30.7SLC17A5, CCK
4cholangitis30.6SLC17A5, CFTR
5cholecystitis30.6CCK
6cystic fibrosis30.6SCT, MPO, SPINK1, ELANE, CFTR
7obesity30.5CLPS, SLC17A5, CRP, SULT1A3, IL18, CCK
8mediastinitis30.5CRP
9neuroendocrine tumor30.4CCK, SCT, SST
10parotitis30.4SPINK1
11cholelithiasis30.3SST, CCK
12systemic lupus erythematosus30.3IL18, CRP, MPO, SULT1A3
13pancreatic cancer30.3CFTR, CCK, SST, SCT, SPINK1
14hepatocellular carcinoma30.2SPINK1, ELANE, SCT, SLC17A5
15pancreatitis, hereditary30.2SPINK1, CFTR
16duodenal ulcer30.2SCT, CCK, SST
17ulcerative colitis30.2CFTR, MPO, CXCL5, ELANE, IL18, CRP
18proteinuria30.1CFTR, MPO, CRP
19arthritis30.0MPO, IL18, SULT1A3, CXCL5, CRP
20gallbladder disease30.0CCK, CFTR
21diarrhea30.0CFTR, CRP, SST
22peptic ulcer disease30.0SCT, CCK, SST
23portal hypertension29.9SST, SLC17A5
24polyarteritis nodosa29.9MPO
25hepatitis b29.9SULT1A3, SLC17A5
26liver cirrhosis29.9SCT, SLC17A5, SST
27hyperglycemia29.9CRP, CCK, SST, SCT
28gastritis29.9CXCL5, SCT, CCK, SST
29alcoholic pancreatitis29.9SPINK1, CFTR, SCT, ELANE, CCK
30acute respiratory distress syndrome29.9MPO, ELANE
31nephritis29.9MPO, SULT1A3, IL18
32steatorrhea29.9SST, CCK, ELANE, CLPS, SCT, CFTR
33pneumonia29.9CRP, ELANE, CXCL5, MPO, CFTR
34inflammatory bowel disease29.8IL18, MPO, CXCL5, ELANE, SCT, CRP
35rheumatoid arthritis29.8IL18, CRP, CXCL5, PRSS2, MPO, CFTR
36hypertriglyceridemia10.7
37duodenitis10.6
38hepatitis10.6
39diabetic ketoacidosis10.4
40compartment syndrome10.4
41peritonitis10.4
42adenoma10.4
43hemorrhagic fever10.4
44aneurysm10.4
45endotheliitis10.4
46thrombotic thrombocytopenic purpura10.4
47choledochal cyst10.4
48hyperparathyroidism10.4
49purpura10.4
50leukemia10.3

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to acute pancreatitis

Symptoms for Acute Pancreatitis

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Drugs & Therapeutics for Acute Pancreatitis

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Drug clinical trials:

Search ClinicalTrials for Acute Pancreatitis

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

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Anatomical Context for Acute Pancreatitis

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MalaCards organs/tissues related to Acute Pancreatitis:

33
Pancreas, Lung, Neutrophil, Liver, Monocytes, Testes, Kidney, Endothelial, Spleen, T cells, Heart, Smooth muscle, Colon, Breast, Myeloid, Bone, Lymph node, Thymus, Small intestine, Thyroid, B cells, Pancreatic islet, Pituitary

Animal Models for Acute Pancreatitis or affiliated genes

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MGI Mouse Phenotypes related to Acute Pancreatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4SPINK1, CFTR, CLPS, SST, IL18
2MP:00053787.7SLC17A5, GATM, IL18, SST, CLPS, CFTR
3MP:00053867.7CFTR, SCT, CLPS, SST, IL18, GATM
4MP:00053877.5SPINK1, CFTR, MPO, ELANE, SST, IL18
5MP:00053765.6SLC17A5, SPINK1, CFTR, SCT, MPO, CLPS

Publications for Acute Pancreatitis

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Articles related to Acute Pancreatitis:

(show top 50)    (show all 1461)
idTitleAuthorsYear
1
Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. (25878403)
2015
2
Acute pancreatitis and aseptic meningitis: Rare complications of Salmonella paratyphi infection. (25817826)
2015
3
A case of recurrent acute pancreatitis due to intra-articular corticosteroid injection. (24618449)
2014
4
Plasma copeptin levels are associated with prognosis of severe acute pancreatitis. (24184419)
2014
5
Acute pancreatitis: a rare complication in a patient with senior loken syndrome. (24702534)
2014
6
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
7
Early acute pancreatitis in a child with compound heterozygosis a88F508/R1438W/Y1032C cystic fibrosis: a case report. (23883480)
2013
8
Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats. (23959212)
2013
9
Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy. (23468971)
2013
10
Association Analysis of Genetic Variants in the Myosin IXB Gene in Acute Pancreatitis. (24386489)
2013
11
Effects of trimetazidine in acute pancreatitis induced by L-arginine. (23484468)
2013
12
Copeptin is a predictive biomarker of severity in acute pancreatitis. (23332738)
2013
13
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. (23840154)
2013
14
Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog. (23180148)
2013
15
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
16
Evaluation of serum TWEAK concentration in patients with acute pancreatitis. (22356682)
2012
17
Intensive insulin therapy in severe acute pancreatitis: a meta-analysis and systematic review. (23441350)
2012
18
Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. (21963611)
2012
19
Mild acute pancreatitis with vildagliptin use. (23565473)
2012
20
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
21
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
22
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
23
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
24
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (20335783)
2010
25
Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis. (20127414)
2010
26
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
27
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
28
Thrombotic thrombocytopenic purpura associated with severe acute pancreatitis in a context of decreased ADAMTS13 activity: a case report. (18989146)
2008
29
Early inflammatory response in acute pancreatitis is little affected by body mass index. (17852885)
2007
30
Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study. (17295762)
2007
31
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
32
Structural evaluation of plasma alpha2-macroglobulin in acute pancreatitis. (16232083)
2005
33
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
34
Early jejunal nutrition with combined pre- and probiotics in acute pancreatitis--prospective, randomized, double-blind investigations]. (12764986)
2003
35
Red blood cells deformability and oxidative stress in acute pancreatitis. (12454371)
2002
36
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
37
Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin. (10547191)
1999
38
Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin receptor antagonists. (10026436)
1999
39
Clinical evaluation of cholecystokinin-A- receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan. (10026438)
1999
40
Serum levels of extracellular matrix in acute pancreatitis. (10626198)
1999
41
Definition of predictors of a complicated course in acute pancreatitis]. (9931653)
1998
42
A prospective study of serum pancreatic elastase-1 in the diagnosis and assessment of acute pancreatitis. (9669641)
1998
43
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
44
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. (9279965)
1997
45
Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. (8813775)
1996
46
Surgical strategies in acute pancreatitis. (8119641)
1993
47
Informativeness of the methods of early clinical laboratory diagnosis of acute pancreatitis]. (1630081)
1992
48
The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol. (1724678)
1991
49
Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. (2554845)
1989
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Acute Pancreatitis

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Expression for genes affiliated with Acute Pancreatitis

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Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for genes affiliated with Acute Pancreatitis

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Compounds for genes affiliated with Acute Pancreatitis

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Compounds related to Acute Pancreatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1epft4510.0CCK, SCT
2loxiglumide459.9SCT, SST, CCK
3gabexate mesilate459.9CRP, ELANE, SST
4oxyntomodulin45 6110.8SST, SCT, CCK
5omeprazole45 51 30 26 1313.6SST, CCK, CRP, SCT
6taurodeoxycholate459.6CCK, SST, SCT, CLPS
7lactulose459.6SLC17A5, CRP, CCK
8nitroglycerin45 1310.5ELANE, SST, CRP
9ibmx45 61 3011.5SCT, CFTR, SST, CCK
10caffeine45 30 3 51 26 1314.5CFTR, ELANE, SST, CCK
11carbachol45 30 1311.5CCK, CFTR, SCT, SST
121-hydroxyphenazine459.5ELANE, MPO
13ranitidine45 30 26 1312.4IL18, SCT, CCK
14thyroxine45 2610.3SCT, ELANE, SST, SLC17A5
15taurocholate459.3SCT, CFTR, CCK
16trypsinogen459.2SCT, SPINK1, CFTR, PRSS2, ELANE, CCK
17isoproterenol45 1310.2IL18, SST, ELANE, CFTR, SCT
18propylthiouracil45 3 1311.2SLC17A5, ELANE, MPO
19nafamostat mesilate459.1MPO, IL18, ELANE
20cerulein459.1ELANE, CCK, MPO, SCT
21c-peptide459.1SCT, SST, CCK, CRP, SLC17A5
22neopterin459.1ELANE, IL18, CRP, SLC17A5
23dopamine45 30 26 1312.0CCK, CFTR, SCT, SULT1A3, SST
24octreotide45 61 30 1311.8CCK, ELANE, MPO, SCT, SST
25adenylate458.7CCK, SST, ELANE, SCT, CFTR, IL18
26fibrinogen458.7SLC17A5, CRP, SULT1A3, ELANE, IL18
27aspirin45 51 30 2611.7IL18, CCK, ELANE, SULT1A3, CFTR, CRP
28endotoxin458.6CRP, IL18, ELANE, SLC17A5, CXCL5
29cyclosporin a45 30 6110.5SCT, SLC17A5, IL18, ELANE, CFTR, CCK
30folate458.5IL18, CRP, SLC17A5, CCK
31cyclophosphamide45 51 1310.5SST, IL18, MPO, CRP
32prednisolone45 30 1310.5MPO, IL18, SLC17A5, CRP
33dexamethasone45 51 30 1311.5CFTR, SULT1A3, CXCL5, IL18, CCK, SST
34histamine45 30 2610.4IL18, CCK, SCT, MPO, SST
35arginine458.3SULT1A3, SCT, GATM, IL18, SST, CCK
36n acetylcysteine458.3MPO, CFTR, IL18, CRP, SLC17A5
37glutamate458.2IL18, CCK, SST, ELANE, SCT, CFTR
38glutamine458.2IL18, SLC17A5, CFTR, ELANE, CCK, SCT
39cholesterol45 30 26 1311.2IL18, SULT1A3, CLPS, CRP, CCK, SLC17A5
40lactate458.0SLC17A5, SST, CRP, IL18, ELANE, MPO
41testosterone45 61 26 1310.9IL18, CCK, SST, CFTR, SCT, ELANE
42epinephrine45 26 139.9CXCL5, SLC17A5, SST, SCT, CFTR, SULT1A3
43retinoic acid45 268.9IL18, CCK, SST, MPO, SCT, CFTR
44aspartate457.7SLC17A5, GATM, CRP, SULT1A3, IL18, SCT
45acetylcholine45 51 30 26 1311.7ELANE, CFTR, IL18, CCK, SST, MPO
46norepinephrine45 26 139.6IL18, ELANE, CRP, SLC17A5, SULT1A3, CCK
47pge2457.5ELANE, CCK, CXCL5, MPO, SCT, CFTR
48creatinine457.5SULT1A3, MPO, SPINK1, SLC17A5, GATM, IL18
49nitric oxide45 26 139.4CXCL5, SULT1A3, MPO, GATM, SLC17A5, IL18
50calcium45 51 26 1310.0SCT, SPINK1, CRP, CLPS, PRSS2, IL18

GO Terms for genes affiliated with Acute Pancreatitis

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Cellular components related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.3PRSS2, CXCL5, SST, CCK, IL18, CRP
2extracellular regionGO:00055766.6CRP, SPINK1, SCT, CLPS, PRSS2, CXCL5

Biological processes related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to yeastGO:00018789.3ELANE, MPO
2cell-cell signalingGO:00072679.1IL18, SST, CXCL5
3negative regulation of growth of symbiont in hostGO:00441309.1ELANE, MPO

Molecular functions related to Acute Pancreatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5CCK, SST, SCT

Products for genes affiliated with Acute Pancreatitis

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Sources for Acute Pancreatitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet