MCID: ACT027
MIFTS: 55

Acute Pancreatitis malady

Genetic diseases, Gastrointestinal diseases, Endocrine diseases, Rare diseases, Skin diseases, Bone diseases, Immune diseases categories

Summaries for Acute Pancreatitis

About this section


Wikipedia:63 Acute pancreatitis or acute pancreatic necrosis is a sudden inflammation of the pancreas. It can have... more...

MalaCards based summary: Acute Pancreatitis, also known as pancreatitis, acute necrotizing, is related to recurrent acute pancreatitis and cholecystitis. An important gene associated with Acute Pancreatitis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways is Peptide ligand-binding receptors. The compounds epft and loxiglumide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and neutrophil, and related mouse phenotypes are digestive/alimentary and growth/size/body.

Aliases & Classifications for Acute Pancreatitis

About this section

Acute Pancreatitis, Aliases & Descriptions:

Name: Acute Pancreatitis 9 11 43 60
Pancreatitis, Acute Necrotizing 60
Acute Necrotizing Pancreatitis 9
Acute Pancreatitis Unspecified 9
 
Pancreatitis Necrotizing 9
Necrotizing Pancreatitis 43
Acute Pancreatitis Nos 9


Classifications:



External Ids:

Disease Ontology9 DOID:2913
ICD9CM27 577.0
ICD1025 K85

Related Diseases for Acute Pancreatitis

About this section

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary acute pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Spink1-Related Hereditary Pancreatitis Ctrc-Related Hereditary Pancreatitis
Cftr-Related Hereditary Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1recurrent acute pancreatitis32.1SPINK1, CFTR, SCT
2cholecystitis31.2CCK
3mediastinitis31.1CRP
4parotitis31.1SPINK1
5obstructive jaundice31.0CCK, SLC17A5
6cholangitis31.0CFTR, SLC17A5
7pancreatitis, hereditary30.8SPINK1, CFTR
8cholelithiasis30.7SST, CCK
9neuroendocrine tumor30.7CCK, SST, SCT
10duodenal ulcer30.5CCK, SST, SCT
11gallbladder disease30.5CFTR, CCK
12pancreatitis30.5SST, ELANE, PRSS2, CLPS, SULT1A3, MPO
13cystic fibrosis30.4SPINK1, CFTR, SCT, MPO, ELANE
14pancreatic cancer30.3CCK, SST, SCT, CFTR, SPINK1
15diarrhea30.3CRP, SST, CFTR
16peptic ulcer disease30.3SCT, SST, CCK
17portal hypertension30.3SST, SLC17A5
18polyarteritis nodosa30.3MPO
19hepatitis b30.2SULT1A3, SLC17A5
20proteinuria30.2CRP, MPO, CFTR
21liver cirrhosis30.1SLC17A5, SST, SCT
22hyperglycemia30.1CRP, CCK, SST, SCT
23hepatocellular carcinoma30.0SPINK1, SCT, ELANE, SLC17A5
24gastritis30.0SCT, CXCL5, SST, CCK
25alcoholic pancreatitis30.0SPINK1, CFTR, SCT, ELANE, CCK
26systemic lupus erythematosus30.0CRP, IL18, SULT1A3, MPO
27obesity29.9SLC17A5, CRP, IL18, CCK, CLPS, SULT1A3
28acute respiratory distress syndrome29.9ELANE, MPO
29nephritis29.7MPO, SULT1A3, IL18
30steatorrhea29.7CFTR, CCK, SST, ELANE, CLPS, SCT
31pneumonia29.5CFTR, MPO, CXCL5, ELANE, CRP
32ulcerative colitis29.5CFTR, MPO, CXCL5, ELANE, IL18, CRP
33arthritis29.5MPO, SULT1A3, CXCL5, IL18, CRP
34inflammatory bowel disease29.1SCT, MPO, CXCL5, ELANE, IL18, CRP
35rheumatoid arthritis28.9CRP, IL18, ELANE, CXCL5, PRSS2, MPO
36hypertriglyceridemia10.7
37duodenitis10.6
38hepatitis10.6
39tropical calcific pancreatitis10.6SPINK1
40angiodysplasia10.5SST
41dumping syndrome10.5SST
42adult-onset still's disease10.5CRP
43aspergillosis10.5ELANE
44duodenogastric reflux10.5CCK
45emphysema due to aat deficiency10.5ELANE
46scrub typhus10.5SLC17A5
47diabetic ketoacidosis10.4
48compartment syndrome10.4
49peritonitis10.4
50cystic kidney10.4CFTR, SCT

Graphical network of the top 20 diseases related to Acute Pancreatitis:



Diseases related to acute pancreatitis

Symptoms for Acute Pancreatitis

About this section

Drugs & Therapeutics for Acute Pancreatitis

About this section

Drug clinical trials:

Search ClinicalTrials for Acute Pancreatitis

Search NIH Clinical Center for Acute Pancreatitis

Genetic Tests for Acute Pancreatitis

About this section

Anatomical Context for Acute Pancreatitis

About this section

MalaCards organs/tissues related to Acute Pancreatitis:

31
Pancreas, Lung, Neutrophil, Liver, Monocytes, Testes, Kidney, Endothelial, Spleen, T cells, Heart, Smooth muscle, Colon, Breast, Myeloid, Bone, Lymph node, Thymus, Small intestine, Thyroid, B cells, Pancreatic islet, Pituitary

Animal Models for Acute Pancreatitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Acute Pancreatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4SPINK1, CFTR, CLPS, SST, IL18
2MP:00053787.7SLC17A5, GATM, IL18, SST, CLPS, CFTR
3MP:00053867.7CFTR, SCT, CLPS, SST, IL18, GATM
4MP:00053877.5SPINK1, CFTR, MPO, ELANE, SST, IL18
5MP:00053765.6SLC17A5, SPINK1, CFTR, SCT, MPO, CLPS

Publications for Acute Pancreatitis

About this section

Articles related to Acute Pancreatitis:

(show top 50)    (show all 1461)
idTitleAuthorsYear
1
Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. (25878403)
2015
2
Acute pancreatitis and aseptic meningitis: Rare complications of Salmonella paratyphi infection. (25817826)
2015
3
A case of recurrent acute pancreatitis due to intra-articular corticosteroid injection. (24618449)
2014
4
Plasma copeptin levels are associated with prognosis of severe acute pancreatitis. (24184419)
2014
5
Acute pancreatitis: a rare complication in a patient with senior loken syndrome. (24702534)
2014
6
Early enteral nutrition is superior to delayed enteral nutrition for the prevention of infected necrosis and mortality in acute pancreatitis. (23508012)
2013
7
Early acute pancreatitis in a child with compound heterozygosis a88F508/R1438W/Y1032C cystic fibrosis: a case report. (23883480)
2013
8
Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats. (23959212)
2013
9
Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy. (23468971)
2013
10
Association Analysis of Genetic Variants in the Myosin IXB Gene in Acute Pancreatitis. (24386489)
2013
11
Effects of trimetazidine in acute pancreatitis induced by L-arginine. (23484468)
2013
12
Copeptin is a predictive biomarker of severity in acute pancreatitis. (23332738)
2013
13
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis. (23840154)
2013
14
Haemolytic anaemia and acute pancreatitis associated with zinc toxicosis in a dog. (23180148)
2013
15
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
16
Evaluation of serum TWEAK concentration in patients with acute pancreatitis. (22356682)
2012
17
Intensive insulin therapy in severe acute pancreatitis: a meta-analysis and systematic review. (23441350)
2012
18
Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications. (21963611)
2012
19
Mild acute pancreatitis with vildagliptin use. (23565473)
2012
20
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
21
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
22
An unusual complication of hydronephrosis due to acute pancreatitis after endoscopic retrograde cholangiopancreatography. (20494410)
2011
23
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
24
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. (20335783)
2010
25
Epidermal growth factor serum levels and the 61 G/A polymorphism in patients with acute pancreatitis. (20127414)
2010
26
Relapsing acute pancreatitis caused by protein plugs in a remnant choledochal cyst. (20703851)
2010
27
Obesity alters cytokine gene expression and promotes liver injury in rats with acute pancreatitis. (18223607)
2008
28
Thrombotic thrombocytopenic purpura associated with severe acute pancreatitis in a context of decreased ADAMTS13 activity: a case report. (18989146)
2008
29
Early inflammatory response in acute pancreatitis is little affected by body mass index. (17852885)
2007
30
Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: pilot study. (17295762)
2007
31
Recurrent acute pancreatitis in a patient with type IIb hyperlipoproteinemia: a case report and review of the literature in Korea. (16502498)
2006
32
Structural evaluation of plasma alpha2-macroglobulin in acute pancreatitis. (16232083)
2005
33
Anti-cytokine therapy for severe acute pancreatitis]. (15552897)
2004
34
Early jejunal nutrition with combined pre- and probiotics in acute pancreatitis--prospective, randomized, double-blind investigations]. (12764986)
2003
35
Red blood cells deformability and oxidative stress in acute pancreatitis. (12454371)
2002
36
Detection of choledocholithiasis by EUS in acute pancreatitis: a prospective evaluation in 100 consecutive patients. (11522972)
2001
37
Tissue kallikrein in severe acute pancreatitis in patients treated with high-dose intraperitoneal aprotinin. (10547191)
1999
38
Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin receptor antagonists. (10026436)
1999
39
Clinical evaluation of cholecystokinin-A- receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan. (10026438)
1999
40
Serum levels of extracellular matrix in acute pancreatitis. (10626198)
1999
41
Definition of predictors of a complicated course in acute pancreatitis]. (9931653)
1998
42
A prospective study of serum pancreatic elastase-1 in the diagnosis and assessment of acute pancreatitis. (9669641)
1998
43
Acute pancreatitis complicating pregnancy in a patient with co-existing choledochal cyst. (9159049)
1997
44
Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro. (9279965)
1997
45
Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. (8813775)
1996
46
Surgical strategies in acute pancreatitis. (8119641)
1993
47
Informativeness of the methods of early clinical laboratory diagnosis of acute pancreatitis]. (1630081)
1992
48
The role of oxygen-derived free radicals in two models of experimental acute pancreatitis: effects of catalase, superoxide dismutase, dimethylsulfoxide, and allopurinol. (1724678)
1991
49
Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. (2554845)
1989
50
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952

Variations for Acute Pancreatitis

About this section

Expression for genes affiliated with Acute Pancreatitis

About this section
Search GEO for disease gene expression data for Acute Pancreatitis.

Pathways for genes affiliated with Acute Pancreatitis

About this section

Compounds for genes affiliated with Acute Pancreatitis

About this section

Compounds related to Acute Pancreatitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idCompoundScoreTop Affiliating Genes
1epft4310.0CCK, SCT
2loxiglumide439.9SCT, SST, CCK
3gabexate mesilate439.9CRP, ELANE, SST
4oxyntomodulin43 5910.8SST, SCT, CCK
5omeprazole43 49 28 24 1213.6SST, CCK, CRP, SCT
6taurodeoxycholate439.6CCK, SST, SCT, CLPS
7lactulose439.6SLC17A5, CRP, CCK
8nitroglycerin43 1210.5ELANE, SST, CRP
9ibmx43 59 2811.5SCT, CFTR, SST, CCK
10caffeine43 28 2 49 24 1214.5CFTR, ELANE, SST, CCK
11carbachol43 28 1211.5CCK, CFTR, SCT, SST
121-hydroxyphenazine439.5ELANE, MPO
13ranitidine43 28 24 1212.4IL18, SCT, CCK
14thyroxine43 2410.3SCT, ELANE, SST, SLC17A5
15taurocholate439.3SCT, CFTR, CCK
16trypsinogen439.2SCT, SPINK1, CFTR, PRSS2, ELANE, CCK
17isoproterenol43 1210.2IL18, SST, ELANE, CFTR, SCT
18propylthiouracil43 2 1211.2SLC17A5, ELANE, MPO
19nafamostat mesilate439.1MPO, IL18, ELANE
20cerulein439.1ELANE, CCK, MPO, SCT
21c-peptide439.1SCT, SST, CCK, CRP, SLC17A5
22neopterin439.1ELANE, IL18, CRP, SLC17A5
23dopamine43 28 24 1212.0CCK, CFTR, SCT, SULT1A3, SST
24octreotide43 59 28 1211.8CCK, ELANE, MPO, SCT, SST
25adenylate438.7CCK, SST, ELANE, SCT, CFTR, IL18
26fibrinogen438.7SLC17A5, CRP, SULT1A3, ELANE, IL18
27aspirin43 49 28 2411.7IL18, CCK, ELANE, SULT1A3, CFTR, CRP
28endotoxin438.6CRP, IL18, ELANE, SLC17A5, CXCL5
29cyclosporin a43 28 5910.5SCT, SLC17A5, IL18, ELANE, CFTR, CCK
30folate438.5IL18, CRP, SLC17A5, CCK
31cyclophosphamide43 49 1210.5SST, IL18, MPO, CRP
32prednisolone43 28 1210.5MPO, IL18, SLC17A5, CRP
33dexamethasone43 49 28 1211.5CFTR, SULT1A3, CXCL5, IL18, CCK, SST
34histamine43 28 2410.4IL18, CCK, SCT, MPO, SST
35arginine438.3SULT1A3, SCT, GATM, IL18, SST, CCK
36n acetylcysteine438.3MPO, CFTR, IL18, CRP, SLC17A5
37glutamate438.2IL18, CCK, SST, ELANE, SCT, CFTR
38glutamine438.2IL18, SLC17A5, CFTR, ELANE, CCK, SCT
39cholesterol43 28 24 1211.2IL18, SULT1A3, CLPS, CRP, CCK, SLC17A5
40lactate438.0SLC17A5, SST, CRP, IL18, ELANE, MPO
41testosterone43 59 24 1210.9IL18, CCK, SST, CFTR, SCT, ELANE
42epinephrine43 24 129.9CXCL5, SLC17A5, SST, SCT, CFTR, SULT1A3
43retinoic acid43 248.9IL18, CCK, SST, MPO, SCT, CFTR
44aspartate437.7SLC17A5, GATM, CRP, SULT1A3, IL18, SCT
45acetylcholine43 49 28 24 1211.7ELANE, CFTR, IL18, CCK, SST, MPO
46norepinephrine43 24 129.6IL18, ELANE, CRP, SLC17A5, SULT1A3, CCK
47pge2437.5ELANE, CCK, CXCL5, MPO, SCT, CFTR
48creatinine437.5SULT1A3, MPO, SPINK1, SLC17A5, GATM, IL18
49nitric oxide43 24 129.4CXCL5, SULT1A3, MPO, GATM, SLC17A5, IL18
50calcium43 49 24 1210.0SCT, SPINK1, CRP, CLPS, PRSS2, IL18

GO Terms for genes affiliated with Acute Pancreatitis

About this section

Cellular components related to Acute Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.3PRSS2, CXCL5, SST, CCK, IL18, CRP
2extracellular regionGO:00055766.6CRP, SPINK1, SCT, CLPS, PRSS2, CXCL5

Biological processes related to Acute Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to yeastGO:00018789.3ELANE, MPO
2cell-cell signalingGO:00072679.1IL18, SST, CXCL5
3negative regulation of growth of symbiont in hostGO:00441309.1ELANE, MPO

Molecular functions related to Acute Pancreatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5CCK, SST, SCT

Products for genes affiliated with Acute Pancreatitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Acute Pancreatitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet