MCID: ACT078
MIFTS: 45

Acute Porphyria malady

Categories: Genetic diseases, Metabolic diseases, Rare diseases, Blood diseases, Liver diseases

Aliases & Classifications for Acute Porphyria

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Aliases & Descriptions for Acute Porphyria:

Name: Acute Porphyria 10 12
Porphyrias, Hepatic 36 65
 
Acute Intermittent Porphyria 65
Hepatic Porphyria 10

Classifications:



External Ids:

Disease Ontology10 DOID:3133
SNOMED-CT59 55056006
MeSH36 D017094
UMLS65 C0162533

Summaries for Acute Porphyria

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Disease Ontology:10 A porphyria that has symptom abdominal pain, has symptom neuropathy, has symptom autonomic instability and has symptom psychosis.

MalaCards based summary: Acute Porphyria, also known as porphyrias, hepatic, is related to porphyria cutanea tarda and coproporphyria, and has symptoms including abdominal pain, neuropathy and autonomic instability. An important gene associated with Acute Porphyria is FECH (Ferrochelatase), and among its related pathways are Glycine, serine and threonine metabolism and Porphyrin and chlorophyll metabolism. The drugs chlorpromazine and chlorpromazine hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and endothelial, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Related Diseases for Acute Porphyria

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Diseases in the Porphyria family:

acute porphyria Congenital Porphyria
Urod-Related Porphyrias

Diseases related to Acute Porphyria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1porphyria cutanea tarda28.5ALAD, CPOX, FECH, HFE, HMBS, PPOX
2coproporphyria28.0ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS
3porphyria, acute hepatic12.0
4porphyria, acute intermittent11.4
5chester porphyria10.6
6protoporphyria, erythropoietic, autosomal recessive10.4
7porphyria10.4
8lymphoma10.1
9leukemia10.1
10neuronitis10.1
11obesity10.0
12hepatitis10.0
13myeloma10.0
14thyroiditis10.0
15neuropathy10.0
16gastric small cell carcinoma10.0FECH, HFE
17xq28 duplication syndrome, int22h1/int22h2 mediated10.0ALAS2, FECH
18ah amyloidosis10.0HFE, UROD
19prostate cancer9.9
20hepatocellular carcinoma9.9
21breast cancer9.9
22multiple myeloma9.9
23b-cell lymphomas9.9
24thrombocytopenia9.9
25prostatitis9.9
26ovarian cancer9.9
27pancreatitis9.9
28acute zonal occult outer retinopathy9.9
29cardiomyopathy9.9
30marantic endocarditis9.9ALAS1, ALAS2
31undetermined early-onset epileptic encephalopathy9.9HFE, UROD
32pneumoconiosis due to talc9.9HFE, UROD
33schizophrenia9.8
34pheochromocytoma9.8
35gastrointestinal stromal tumor9.8
36neuroblastoma9.8
37colorectal cancer9.8
38systemic lupus erythematosus9.8
39lung cancer9.8
40atopy9.8
41cystinuria9.8
42asthma9.8
43renal cell carcinoma9.8
44alcohol dependence9.8
45beckwith-wiedemann syndrome9.8
46celiac disease9.8
47cystic fibrosis9.8
48chondrosarcoma9.8
49anorexia nervosa9.8
50optic nerve hypoplasia9.8

Graphical network of the top 20 diseases related to Acute Porphyria:



Diseases related to acute porphyria

Symptoms for Acute Porphyria

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Symptoms:

 10
  • abdominal pain
  • neuropathy
  • autonomic instability
  • psychosis

Drugs & Therapeutics for Acute Porphyria

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Drugs for Acute Porphyria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IronapprovedPhase 3, Phase 210217439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
2
Deferasiroxapproved, investigationalPhase 3, Phase 286201530-41-85493381
Synonyms:
Deferasiroxum
Deferasiroxum [inn-latin]
 
Exjade
ICL 670
ICL 670a
deferasirox
3
ColestipolapprovedPhase 2, Phase 3550925-79-662816
Synonyms:
Colestid
Colestipol Hydrochloride
 
Colestipolum
Colestipolum [INN-Latin]
Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane
Epichlorohydrin-tetraethylenepentamine polymer
4Hormone AntagonistsPhase 3, Phase 210002
5Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 3, Phase 29988
6alpha-MSHPhase 3, Phase 212581-05-5
7Chelating AgentsPhase 3, Phase 2667
8HormonesPhase 3, Phase 211748
9Iron Chelating AgentsPhase 3, Phase 2178
10AntimetabolitesPhase 2, Phase 39454
11Hypolipidemic AgentsPhase 2, Phase 32228
12cysteineNutraceuticalPhase 3150
13
HydroxychloroquineapprovedPhase 2136118-42-33652
Synonyms:
(+-)-Hydroxychloroquine
(┬▒)-hydroxychloroquine
118-42-3
2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol
2-((4-((7-chloro-4-Quinolyl)amino)pentyl)ethylamino)ethanol
2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol
2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
5-22-10-00280 (Beilstein Handbook Reference)
7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline
7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline
7-chloro-4-(4-(Ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline
7-chloro-4-(4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline
7-chloro-4-[4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline
7-chloro-4-[5-(N-Ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline
747-36-4 (sulfate (1:1) salt)
AC1L1GEW
BRN 0253894
C07043
C18H26ClN3O
CHEMBL1535
CID3652
D08050
DB01611
DivK1c_000942
EINECS 204-249-8
Gen-Hydroxychloroquine 200mg Tablets
HCQ
HMS502P04
Hidroxicloroquina
Hidroxicloroquina [INN-Spanish]
Hydroxychlorochin
 
Hydroxychloroguine
Hydroxychloroquine (INN)
Hydroxychloroquine Sulfate
Hydroxychloroquine Sulfate (1:1) Salt
Hydroxychloroquine [INN:BAN]
Hydroxychloroquine sulfate
Hydroxychloroquinum
Hydroxychloroquinum [INN-Latin]
IDI1_000942
Idrossiclorochina
Idrossiclorochina [DCIT]
KBio1_000942
LS-66614
MolPort-003-847-792
NCGC00159483-02
NINDS_000942
NSC4375
Oxichlorochine
Oxichlorochinum
Oxichloroquine
Oxychlorochin
Oxychloroquine
PlaqueN/A
Plaquenil
Polirreumin
Polirreumin (TN)
Quensyl
SPBio_001116
ST072188
Spectrum2_001238
Spectrum5_001697
UNII-4QWG6N8QKH
WIN 1258
hydroxychloroquine
14
TinPhase 1, Phase 2357440-31-5
Synonyms:
CI Pigment metal 5
Haro Mix ZT-514
Innohep
Metallic tin
SN
 
Silver matt powder
Stanum
Tin flake
Tin powder
Tindamax
ZINN
15Tin mesoporphyrinPhase 1, Phase 214
16Antirheumatic AgentsPhase 28496
17Antiprotozoal AgentsPhase 21730
18Anti-Infective AgentsPhase 217220
19Antiparasitic AgentsPhase 21854
20AntimalarialsPhase 21058
21Liver ExtractsPhase 13572
22
Aminolevulinic acidapproved142106-60-5137
Synonyms:
106-60-5
35BEC718-C970-426A-9859-BF58284C60B4
5-ALA
5-Amino-4-oxo-Pentanoate
5-Amino-4-oxo-Pentanoic acid
5-Amino-4-oxopentanoate
5-Amino-4-oxopentanoic acid
5-Amino-4-oxovalerate
5-Amino-4-oxovaleric acid
5-Amino-Levulinate
5-Amino-Levulinic acid
5-Aminolaevulinate
5-Aminolaevulinic acid
5-Aminolevulinate
5-Aminolevulinate hydrochloride
5-Aminolevulinic acid
5-amino-levulinate
5451-09-2
AC-054
AC1L18K9
AKOS003587520
ALA
ALA-PDT
Aladerm
Amino-levulinic acid
Aminolevulinate
Aminolevulinic
Aminolevulinic acid
BIDD:GT0260
BSPBio_003407
C00430
CCRIS 8958
CHEBI:17549
CHEMBL601
CID137
CPD000857229
 
D07567
DALA
DB00855
DivK1c_006954
EINECS 203-414-1
I14-10101
KBio1_001898
KBio2_002062
KBio2_004630
KBio2_007198
KBio3_002627
KBioGR_001176
KBioSS_002062
Kerastick
LMFA01100055
LS-101793
Levulan Kerastick
Levulinic acid, 5-amino- (8CI)
MLS001333097
MLS001333098
MolPort-001-788-423
NCGC00178086-01
Pentanoic acid, 5-amino-4-oxo- (9CI)
SAM002589919
SMR000857229
SPBio_001843
ST50819610
SpecPlus_000858
Spectrum2_001662
Spectrum3_001654
Spectrum4_000618
Spectrum5_001505
Spectrum_001582
UNII-88755TAZ87
delta-ALA
delta-Aminolevulinate
delta-Aminolevulinic acid
delta-aminolevulinic acid

Interventional clinical trials:

(show all 32)
idNameStatusNCT IDPhase
1Pilot Trial of Deferasirox in the Treatment of Porphyria Cutanea TardaCompletedNCT00599326Phase 3
2Sorbent Therapy of the Cutaneous PorphyriasCompletedNCT01422915Phase 2, Phase 3
3Phase III Study of L-Cysteine in Patients With Erythropoietic ProtoporphyriaCompletedNCT00004940Phase 3
4Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP)CompletedNCT00979745Phase 3
5Phase III Confirmatory Study in Erythropoietic ProtoporphyriaActive, not recruitingNCT01605136Phase 3
6Porphozym in the Treatment of Acute Attacks in AIPCompletedNCT00418795Phase 2
7Phase II Confirmatory Study in Erythropoietic Protoporphyria (EPP)CompletedNCT01097044Phase 2
8Phase I/II Study of Heme Arginate and Tin Mesoporphyrin for Acute PorphyriaCompletedNCT00004789Phase 1, Phase 2
9Studies in Porphyria III: Heme and Tin Mesoporphyrin in Acute PorphyriasCompletedNCT00004396Phase 2
10Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea TardaRecruitingNCT01573754Phase 2
11Safety and Efficacy of Oral Deferasirox in Patients With Porphyria Cutanea TardaRecruitingNCT01284946Phase 2
12Controlled Trial of Panhematin in Treatment of Acute Attacks of PorphyriaRecruitingNCT02180412Phase 2
13Heme Arginate in Cardiac Surgery PatientsNot yet recruitingNCT02142699Phase 2
14Phase I Gene Therapy Clinical Trial Using the Vector rAAV2/5-PBGD for the Treatment of Acute Intermittent PorphyriaCompletedNCT02082860Phase 1
15Phase I Study of Heme Arginate With or Without Tin Mesoporphyrin in Patients With Acute Attacks of PorphyriaCompletedNCT00004398Phase 1
16Hemin in Healthy SubjectsCompletedNCT00882804Phase 1
17Phase I Study of Tin Mesoporphyrin in Patients on Long Term Heme Therapy for Prevention of Acute Attacks of PorphyriaCompletedNCT00004397Phase 1
18A Phase 1 Study of ALN-AS1 in Patients With Acute Intermittent Porphyria (AIP)RecruitingNCT02452372Phase 1
19Risk Factors of Porphyria Cutanea Tarda (PCT)CompletedNCT00213772
20Study of the Pathogenesis of Porphyria Cutanea TardaCompletedNCT00005103
21Observational Study of Acute Intermittent Porphyria PatientsCompletedNCT02076763
22Study of Cysteine Hydrochloride for Erythropoietic ProtoporphyriaCompletedNCT00004831
23Study of Nutritional Factors in PorphyriaCompletedNCT00004788
24Studies in Porphyria IV: Gonadotropin-Releasing Hormone (GnRH) Analogues for Prevention of Cyclic AttacksCompletedNCT00004330
25Longitudinal Study of the PorphyriasRecruitingNCT01561157
26Clinical Diagnosis of Acute PorphyriaRecruitingNCT01568554
27Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))RecruitingNCT01880983
28Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial ImpactRecruitingNCT01688895
29Does Exercise and Heat Increase the Lightsensibility in Patients With Erythropoietic ProtoporphyriaRecruitingNCT00206869
30EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)Active, not recruitingNCT02240784
31Dental Health, Diet, Inflammation and Biomarkers in Patients With Acute Intermittent Porphyria(AIP)Not yet recruitingNCT01617642
32Effect of Isoniazid on Protoporphyrin Levels in Erythropoietic ProtoporphyriaWithdrawnNCT01550705

Search NIH Clinical Center for Acute Porphyria

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: porphyrias, hepatic

Genetic Tests for Acute Porphyria

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Anatomical Context for Acute Porphyria

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MalaCards organs/tissues related to Acute Porphyria:

33
Liver, Breast, Endothelial, Lung, Brain, Colon, Kidney

Animal Models for Acute Porphyria or affiliated genes

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MGI Mouse Phenotypes related to Acute Porphyria:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5FECH, GLUL, HFE, UROD, UROS
2MP:00053766.4ALAS2, FECH, GLUL, HFE, HMBS, PC
3MP:00107686.4ALAS1, ALAS2, FECH, GLUL, HFE, HMBS

Publications for Acute Porphyria

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Articles related to Acute Porphyria:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Predicting tularemia with clinical, laboratory and demographical findings in the ED. (26577431)
2016
2
Risk and Protective Factors for HIV Self-disclosure among Poor African-American Women Living with HIV/AIDS. (25897863)
2015
3
Effects of triploidy incidence on clinical outcomes for IVF-ET cycles in different ovarian stimulation protocols. (26220642)
2015
4
Dietary Patterns and Their Associations with the Diet Quality Index-International (DQI-I) in Korean Women with Gestational Diabetes Mellitus. (26566516)
2015
5
Solitary extramedullary plasmacytoma of the penis. (25125899)
2014
6
Development in anterior segment imaging for glaucoma. (24370972)
2013
7
The role of imaging in the diagnosis and management of otosclerosis. (23921926)
2013
8
Imaging analysis of hepatoblastoma resectability across neoadjuvant chemotherapy. (23845613)
2013
9
Trends of drug-resistance-associated mutations in the reverse transcriptase gene of HIV type 1 isolates from North India. (24142273)
2013
10
Oral immunization with cholera toxin provides protection against Campylobacter jejuni in an adult mouse intestinal colonization model. (23653448)
2013
11
Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease. (23384655)
2013
12
Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. (23440202)
2013
13
CD62L as a therapeutic target in chronic lymphocytic leukemia. (23948971)
2013
14
Human cytomegalovirus immediate early gene expression in the osteosarcoma line U2OS is repressed by the cell protein ATRX. (21310198)
2011
15
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
16
2-DE-based proteomic investigation of the saliva of the Amazonian triatomine vectors of Chagas disease: Rhodnius brethesi and Rhodnius robustus. (21362504)
2011
17
Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial. (21062335)
2011
18
Seton drainage in high anal fistula. (21279366)
2011
19
Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide. (19751100)
2010
20
Prenatal features of Costello syndrome: ultrasonographic findings and atrial tachycardia. (19382114)
2009
21
Early death of Japanese encephalitis virus-infected mice administered a neutralizing cross-reactive monoclonal antibody against glycoprotein E. (19941401)
2009
22
Expression of CD44 is associated with a metastatic pattern of human neuroblastoma cells in a SCID mouse xenograft model. (18612220)
2008
23
Brain-derived neurotrophic factor gene variation influences cerebrospinal fluid 3-methoxy-4-hydroxyphenylglycol concentrations in healthy volunteers. (18781277)
2008
24
Semenogelins in the human retina: Differences in distribution and content between AMD and normal donor tissues. (18036592)
2008
25
Optic tract hemorrhage after pituitary apoplexy. (17213443)
2007
26
Distribution of collagen XVII in the human brain. (17555727)
2007
27
Characterization of NKT-cell hybridomas expressing invariant T-cell antigen receptors. (17510531)
2007
28
P53 expression is associated with malignant potential in xenograft tissues of a fibrosarcoma mouse model. (17465229)
2007
29
Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. (17786030)
2007
30
Genetics of myeloid malignancies: pathogenetic and clinical implications. (16155011)
2005
31
Molybdenum cofactor deficiency presenting as neonatal hyperekplexia: a clinical, biochemical and genetic study. (16429380)
2005
32
Protein and mRNA expression levels of VEGF-A and TGF-beta1 in different types of human coronary atherosclerotic lesions. (15754021)
2005
33
Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior. (12946942)
2004
34
Autosomal dominant growth hormone deficiency disrupts secretory vesicles in vitro and in vivo in transgenic mice. (12538635)
2003
35
Subcellular localization and mechanisms of nucleocytoplasmic trafficking of steroid receptor coactivator-1. (12791702)
2003
36
Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction. (11792332)
2002
37
Pharmacogenomics and pharmainformatics]. (11808338)
2002
38
A novel gene is disrupted at a 14q13 breakpoint of t(2;14) in a patient with mirror-image polydactyly of hands and feet. (11954550)
2002
39
Canavan disease: a review of recent developments. (11589315)
2001
40
Synaptosomal proteins, beta-soluble N-ethylmaleimide-sensitive factor attachment protein (beta-SNAP), gamma-SNAP and synaptotagmin I in brain of patients with Down syndrome and Alzheimer's disease. (11244216)
2001
41
A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic- depressive patients. (10822345)
2000
42
Increased testosterone production in vitro by Leydig cells from rats with severe autoimmune orchitis. (9568526)
1997
43
Identification of DNA binding-site preferences for nuclear factor I-A. (8706826)
1996
44
Melperone in the treatment of iatrogenic psychosis in Parkinson's disease. (8934152)
1996
45
Nitric oxide and peroxynitrite production by human erythrocytes: a causative factor of toxic anemia in breast cancer patients. (7544567)
1995
46
Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer. (1855215)
1991
47
Expression of human chromosomal proteins HMG-14 and HMG-17 in Saccharomyces cerevisiae. (2226652)
1990
48
Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes. (2568930)
1989
49
Capgras syndrome heralding the development of dementia. (3224233)
1988
50
Angioma Serpiginosum (Crocker). (19993205)
1945

Variations for Acute Porphyria

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Expression for genes affiliated with Acute Porphyria

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Search GEO for disease gene expression data for Acute Porphyria.

GO Terms for genes affiliated with Acute Porphyria

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Biological processes related to Acute Porphyria according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1cellular response to amine stimulusGO:007141810.4HMBS, UROS
2cellular response to arsenic-containing substanceGO:007124310.2UROD, UROS
3cellular response to lead ionGO:007128410.0ALAD, HMBS
4response to cobalt ionGO:003202510.0ALAD, HMBS
5response to metal ionGO:001003810.0ALAD, FECH
6response to nutrient levelsGO:00316679.9ALAD, HMBS
7cellular response to dexamethasone stimulusGO:00715499.8FECH, HMBS
8response to mercury ionGO:00466899.8ALAD, UROD
9response to zinc ionGO:00100439.7ALAD, HMBS
10response to lead ionGO:00102889.6ALAD, FECH, HMBS
11tetrapyrrole biosynthetic processGO:00330149.5ALAD, HMBS, UROS
12response to methylmercuryGO:00515979.5ALAD, HMBS, UROD
13response to iron ionGO:00100399.3ALAD, CPOX, HFE
14response to ethanolGO:00454719.3ALAD, FECH, UROD
15response to drugGO:00424939.0ALAD, HMBS, PPOX
16protoporphyrinogen IX biosynthetic processGO:00067829.0ALAD, ALAS2, CPOX, HMBS
17response to organic cyclic compoundGO:00140709.0ALAD, HMBS, UROD
18small molecule metabolic processGO:00442818.8ALAD, HMBS, PC, UROD
19heme biosynthetic processGO:00067838.6ALAD, CPOX, FECH, PPOX, UROS
20porphyrin-containing compound metabolic processGO:00067786.3ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS

Molecular functions related to Acute Porphyria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
15-aminolevulinate synthase activityGO:00038709.7ALAS1, ALAS2
2pyridoxal phosphate bindingGO:00301709.6ALAS1, ALAS2

Sources for Acute Porphyria

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet