MCID: ACT040
MIFTS: 41

Acute Poststreptococcal Glomerulonephritis malady

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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Aliases & Descriptions for Acute Poststreptococcal Glomerulonephritis:

Name: Acute Poststreptococcal Glomerulonephritis 8 10 44
Acute Post-Streptococcal Glomerulonephritis 8 61
 
Post-Streptococcal Glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:14064
SNOMED-CT56 68544003
NCIt39 C35443

Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards based summary: Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to glomerulonephritis and impetigo. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (complement factor properdin), and among its related pathways are Dissolution of Fibrin Clot and Prostaglandin Synthesis and Regulation. The compounds haemaccel and bq123 have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and spleen, and related mouse phenotypes are tumorigenesis and immune system.

Related Diseases for Acute Poststreptococcal Glomerulonephritis

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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.8EDNRB, CFP, CCL2, ALB, CD79A
2impetigo31.6SKA2
3membranoproliferative glomerulonephritis31.1CD79A, CFP
4nephritis30.9CFP, CCL2, ALB, CD79A
5autoimmune hemolytic anemia30.9HP, CD79A
6proliferative glomerulonephritis30.8CCL2, CD79A
7sickle cell disease30.5EDN1, PF4, HP
8rheumatoid arthritis30.4PF4, CCL2, HP, PLG, CD79A
9kidney disease30.4CCL2, HP, PLG
10arthritis30.3ALB, PLG, HP, CCL2
11thrombocytopenia30.3CD79A, ALB, PLG, HP, PF4
12nephrotic syndrome30.2SERPINF2, HP, ALB, NPPA, CD79A
13proteinuria29.0EDNRB, EDN1, CFP, PF4, CCL2, HP
14rheumatic fever10.6
15meningoencephalitis10.5CD79A
16pyelonephritis10.5CD79A
17intermediate coronary syndrome10.5PLG
18hypertensive encephalopathy10.4
19purpura10.4
20diffuse alveolar hemorrhage10.4
21protein-losing enteropathy10.4ALB
22hemorrhagic disease10.4SERPINF2, PF4
23hyperthyroxinemia10.4ALB
24agammaglobulinemia10.4CFP, CD79A
25complement deficiency10.4C5, CFP
26immunoglobulin alpha deficiency10.4HP, CD79A
27corneal neovascularization10.4PLG, PF4
28conjunctivitis10.3CD79A, PLG
29protein c deficiency10.3CFP, PLG
30reactive arthritis10.3CD79A, HP
31mitral valve stenosis10.3PF4, NPPA
32cholangitis10.3ALB
33peripheral vascular disease10.3ALB, CD79A
34thrombocytosis10.3SERPINF2, PF4, HP
35thrombophilia due to activated protein c resistance10.3SERPINF2, PF4, PLG
36cerebral hemorrhage10.3
37bardet-biedl syndrome10.3
38pharyngitis10.3
39hemolytic-uremic syndrome10.3
40cerebritis10.3
41rapidly progressive glomerulonephritis10.3
42mesangial proliferative glomerulonephritis10.3
43pneumonia10.3
44uremia10.3
45thrombophilia10.3SERPINF2, PF4, PLG
46thrombophilia due to thrombin defect10.3SERPINF2, PF4, PLG
47meningitis10.2CD79A, ALB, CFP
48intestinal obstruction10.2EDNRB, ALB
49hemolytic anemia10.2
50progeria10.2

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to acute poststreptococcal glomerulonephritis

Symptoms for Acute Poststreptococcal Glomerulonephritis

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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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Drug clinical trials:

Search ClinicalTrials for Acute Poststreptococcal Glomerulonephritis

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

31
Skin, Monocytes, Spleen, Brain

Animal Models for Acute Poststreptococcal Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8EDNRB, CCL2, HP, PLG, ALB
2MP:00053878.6CFP, CCL2, HP, PLG, C5, CD79A
3MP:00053858.4EDNRB, EDN1, CFP, CCL2, HP, PLG
4MP:00053678.4EDNRB, EDN1, HP, PLG, ALB, NPPA
5MP:00028738.3EDN1, CFP, CCL2, ALB, C5, CD79A
6MP:00053766.9CD79A, EDNRB, EDN1, CFP, SERPINF2, PF4

Publications for Acute Poststreptococcal Glomerulonephritis

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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Diffuse alveolar hemorrhage in a patient with acute poststreptococcal glomerulonephritis caused by impetigo. (25876581)
2015
2
Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis. (25554106)
2015
3
Diffuse alveolar hemorrhage as a presentation of acute poststreptococcal glomerulonephritis. (24927907)
2014
4
Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome. (22891230)
2012
5
Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis. (20640906)
2011
6
Elevated plasma levels of N-terminal pro-brain natriuretic peptide in children with acute poststreptococcal glomerulonephritis. (19346734)
2009
7
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. (19095947)
2009
8
Acute poststreptococcal glomerulonephritis superimposed on IgA nephropathy. (18793531)
2008
9
Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis. (15206029)
2004
10
Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. (12654066)
2003
11
Acute poststreptococcal glomerulonephritis and acute rheumatic fever in the same patient: a case report and review of the literature. (12967898)
2003
12
Thrombocytopenia during the course of acute poststreptococcal glomerulonephritis. (12921303)
2003
13
Acute poststreptococcal glomerulonephritis in a child with Bardet-Biedl syndrome. (11793138)
2002
14
Another case of acute poststreptococcal glomerulonephritis with recurrence. (12162274)
2002
15
Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions. (11467793)
2001
16
Acute poststreptococcal glomerulonephritis following circumcision. (11149125)
2000
17
Evaluating the use of penicillin to control outbreaks of acute poststreptococcal glomerulonephritis. (10223684)
1999
18
Renal function during and after childhood acute poststreptococcal glomerulonephritis. (10603146)
1999
19
Acute poststreptococcal glomerulonephritis presenting with hemoptysis. (9686966)
1998
20
Searching for acute poststreptococcal glomerulonephritis-associated Streptococcus pyogenes in Australian aboriginal communities. (9331610)
1997
21
Myocardial dysfunction in a 23-month child with acute poststreptococcal glomerulonephritis. (7793601)
1995
22
Cytokine secretion by peripheral blood monocytes from patients with acute poststreptococcal glomerulonephritis. (7860208)
1994
23
Terminal complement complexes in acute poststreptococcal glomerulonephritis. (7696103)
1994
24
Cell-mediated immune response in acute poststreptococcal glomerulonephritis. (8022104)
1994
25
Plasma atrial natriuretic peptide and endothelin levels in acute poststreptococcal glomerulonephritis. (1482636)
1992
26
Failure to detect unique reactivity to streptococcal streptokinase in either the sera or renal biopsy specimens of patients with acute poststreptococcal glomerulonephritis. (1468160)
1992
27
Role of a streptococcal antigen in the pathogenesis of acute poststreptococcal glomerulonephritis. Characterization of the antigen and a proposed mechanism for the disease. (1578137)
1992
28
Medium- and long-term prognosis of patients with acute poststreptococcal glomerulonephritis. (1922602)
1991
29
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: occurrence in the same patient. (2253249)
1990
30
A case of acute poststreptococcal glomerulonephritis associated with cerebral hemorrhage. (3694896)
1987
31
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. (3530567)
1986
32
Two cases of acute poststreptococcal glomerulonephritis superimposed on rheumatoid arthritis. (6242205)
1984
33
Acute poststreptococcal glomerulonephritis progressing to rapidly progressive glomerulonephritis. (6494975)
1984
34
Characterization of the glomerular antibody in acute poststreptococcal glomerulonephritis. (6965830)
1980
35
Acute poststreptococcal glomerulonephritis in pregnancy: case report with an 18-year follow-up. (7405978)
1980
36
Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins. (314784)
1979
37
Second attack of acute poststreptococcal glomerulonephritis; report of two cases. (524922)
1979
38
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
39
Ultrasonic appearance of acute poststreptococcal glomerulonephritis. (416050)
1978
40
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
41
Prognosis of acute poststreptococcal glomerulonephritis in childhood: prospective study and review of the literature. (1008003)
1976
42
Immune deposits in the spleen of a patient with acute poststreptococcal glomerulonephritis (APSGN). (975639)
1976
43
Defective phagocyte adherence in acute poststreptococcal glomerulonephritis: clinical and laboratory observations. (978322)
1976
44
The fate of subepithelial deposits in acute poststreptococcal glomerulonephritis. (792564)
1976
45
Acute, poststreptococcal glomerulonephritis with failure to resolve. (4536431)
1973
46
Acute poststreptococcal glomerulonephritis. A retrospective study. (4752192)
1973
47
Editorial: Acute poststreptococcal glomerulonephritis. Mechanism and sequelae--attempts at a unifying concept. (4593114)
1972
48
A specific antigen and antibody in acute poststreptococcal glomerulonephritis. (4911994)
1969
49
Acute poststreptococcal glomerulonephritis. A case with minimal urinary abnormalities. (5807650)
1969
50
Acute poststreptococcal glomerulonephritis: immune deposit disease. (4159050)
1966

Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Pathways related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLG, SERPINF2
29.9EDN1, EDNRB
3
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.8C4BPA, C5, CFP
4
Show member pathways
9.5SERPINF2, PF4, PLG
5
Show member pathways
thioredoxin pathway36
9.4CCL2, PLG, ALB
6
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.4C4BPA, C5, PLG, SERPINF2
7
Show member pathways
9.4C5, PLG, CCL2, CFP
8
Show member pathways
9.1SERPINF2, PF4, PLG, ALB
9
Show member pathways
9.1SERPINF2, PF4, PLG, ALB
10
Show member pathways
8.5EDNRB, EDN1, PF4, CCL2, PLG, C5
11
Show member pathways
8.5EDNRB, EDN1, PF4, CCL2, PLG, C5

Compounds for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Compounds related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1haemaccel4410.1ALB, NPPA
2bq12344 2811.0EDNRB, EDN1, NPPA
3ramipril44 1110.9CD79A, NPPA, ALB
4phosphoramidon44 1110.8EDNRB, EDN1, NPPA
5cellulose acetate449.8CD79A, HP, ALB
6probucol44 1110.8CCL2, HP, EDN1
7spironolactone44 60 28 50 1113.8NPPA, ALB, EDNRB
8toki-shakuyaku-san449.8NPPA, EDN1
9sulfasalazine28 44 50 1112.8CD79A, CCL2, HP
10sitaxsentan44 2810.8EDNRB, EDN1
11valsartan44 60 28 1112.7EDN1, CCL2, ALB
12irbesartan44 28 50 1112.7ALB, EDN1, CCL2
13enalapril44 50 1111.7NPPA, ALB, EDN1
14vitamin b12449.6CD79A, CCL2, ALB, HP
158-isoprostane449.6EDN1, CCL2, HP
16pd 145065449.6EDNRB, EDN1
17thyroxine44 2410.5ALB, HP, CD79A, SERPINF2
186-ketoprostaglandin f1alpha449.5PF4, SERPINF2, NPPA, EDN1
19citrate449.4ALB, CD79A, HP, PF4
20hirudin449.4CCL2, PF4, SERPINF2
21verapamil44 28 50 24 1113.4PF4, CCL2, EDN1, EDNRB
22anaphylatoxin449.4HP, PF4, CFP, CCL2, C5
23captopril44 60 50 28 1113.3EDN1, ALB, PLG, NPPA, CD79A
24cyclosporin a44 28 6011.2EDNRB, NPPA, EDN1, CD79A, HP
25losartan44 50 28 1112.2NPPA, EDNRB, EDN1, CCL2, ALB
26polyethylene glycol449.2HP, PF4, NPPA, CD79A, ALB
27indomethacin44 28 60 1112.2CD79A, EDNRB, EDN1, PF4, ALB
28prostacyclin449.2NPPA, CCL2, EDN1, EDNRB, PF4
29polysaccharide449.1HP, CD79A, PF4, SERPINF2, CFP, CCL2
30sodium dodecylsulfate449.1ALB, CCL2, HP, NPPA, CD79A, SERPINF2
31histamine44 28 2411.0CD79A, PF4, EDN1, CCL2, ALB
32testosterone44 60 24 1112.0NPPA, ALB, SERPINF2, CCL2, HP, CD79A
33epinephrine44 24 1111.0EDN1, PF4, HP, NPPA, CD79A, SERPINF2
34norepinephrine44 24 1110.9CD79A, CCL2, NPPA, EDN1, PF4, EDNRB
35arachidonic acid44 28 24 1111.9HP, EDN1, PLG, PF4, ALB
36lactate448.9HP, PF4, CD79A, ALB, C4BPA
37kininogen448.9NPPA, PF4, ALB, PLG, SERPINF2, HP
38nitric oxide44 24 1110.8EDNRB, NPPA, HP, PLG, CCL2, EDN1
39cholesterol44 28 24 1111.8HP, ALB, SERPINF2, PF4, CCL2, C4BPA
40alanine448.8PF4, SERPINF2, HP, EDNRB, CD79A, ALB
41sodium44 249.8EDN1, PF4, HP, ALB, NPPA, EDNRB
42cysteine448.7CFP, PF4, HP, EDNRB, ALB, PLG
43pge2448.7EDNRB, EDN1, HP, PF4, CCL2, CD79A
44arginine448.7CCL2, NPPA, CD79A, SERPINF2, EDN1, EDNRB
45oxygen44 249.6PF4, EDN1, NPPA, PLG, CCL2, EDNRB
46heparin44 28 24 1111.5CFP, C4BPA, CD79A, SERPINF2, ALB, PLG
47creatinine448.5ALB, HP, CCL2, PF4, NPPA, EDN1
48fibrinogen448.4PF4, HP, C4BPA, CD79A, ALB, PLG
49vegf448.1NPPA, EDN1, SERPINF2, PF4, CCL2, HP
50calcium44 50 24 1110.7EDNRB, EDN1, SERPINF2, NPPA, C4BPA, CCL2

GO Terms for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.0SERPINF2, HP, PLG, ALB, C4BPA
2platelet alpha granule lumenGO:00310939.0SERPINF2, PF4, PLG, ALB
3spindle microtubuleGO:00058768.5SKA2, SKA1, SKA3
4condensed chromosome outer kinetochoreGO:00009408.2SKA2, SKA1, SKA3
5extracellular spaceGO:00056157.3PF4, SERPINF2, CFP, EDN1, CCL2, HP
6extracellular regionGO:00055767.1C4BPA, EDN1, CFP, SERPINF2, PF4, CCL2

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:000695710.3C5, CFP
2epithelial fluid transportGO:004204510.2EDNRB, EDN1
3negative regulation of fibrinolysisGO:005191810.2SERPINF2, PLG
4negative regulation of cellular protein metabolic processGO:003226910.2EDNRB, EDN1
5vein smooth muscle contractionGO:001482610.2EDNRB, EDN1
6macrophage chemotaxisGO:004824610.1EDNRB, CCL2
7positive regulation of urine volumeGO:003581010.1EDN1, EDNRB
8regulation of complement activationGO:003044910.1CFP, C5, C4BPA
9positive regulation of renal sodium excretionGO:003581510.1EDNRB, EDN1
10fibrinolysisGO:004273010.1PLG, SERPINF2
11vasoconstrictionGO:004231010.0EDN1, EDNRB
12maternal process involved in parturitionGO:006013710.0CCL2, EDN1
13regulation of pHGO:000688510.0EDNRB, EDN1
14response to organic substanceGO:00100339.8ALB, SERPINF2
15regulation of sensory perception of painGO:00519309.8EDN1, EDNRB
16cell surface receptor signaling pathwayGO:00071669.6C5, CCL2, EDN1, EDNRB
17response to amino acidGO:00432009.5CCL2, EDN1
18response to hypoxiaGO:00016669.4EDN1, CCL2, NPPA
19platelet degranulationGO:00025769.4ALB, PLG, PF4, SERPINF2
20platelet activationGO:00301689.4SERPINF2, PF4, PLG, ALB
21blood coagulationGO:00075969.1ALB, PLG, PF4, SERPINF2
22regulation of microtubule polymerization or depolymerizationGO:00311108.9SKA2, SKA1, SKA3
23chromosome segregationGO:00070598.8SKA2, SKA1, SKA3

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:00162099.8ALB, HP
2chemokine activityGO:00080099.1PF4, CCL2, C5
3protein bindingGO:00055155.5C4BPA, EDNRB, EDN1, SFMBT1, SERPINF2, HP

Sources for Acute Poststreptococcal Glomerulonephritis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet