MCID: ACT040
MIFTS: 43

Acute Poststreptococcal Glomerulonephritis malady

Summaries for Acute Poststreptococcal Glomerulonephritis

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33MalaCards
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MalaCards: Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to rheumatic fever and nephritis. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (complement factor properdin), and among its related pathways are Activation of C3 and C5 and Dissolution of Fibrin Clot. The compounds norepinephrine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include spleen, brain and skin, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt
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Aliases & Descriptions:

acute poststreptococcal glomerulonephritis 8 10 45
acute post-streptococcal glomerulonephritis 8 61
post-streptococcal glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:14064
SNOMED-CT57 68544003
NCIt40 C35443

Related Diseases for Acute Poststreptococcal Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatic fever30.8SKA2
2nephritis30.8CCL2, CD79A, CFP, ALB
3arthritis30.5CCL2, HP, PLG, ALB
4membranoproliferative glomerulonephritis30.3CFP, CD79A
5proliferative glomerulonephritis30.3CCL2, CD79A
6sickle cell disease30.3EDN1, HP, PF4
7thrombocytopenia30.3ALB, PLG, PF4, HP, CD79A
8immune-complex glomerulonephritis10.6
9hypertensive encephalopathy10.4
10diffuse alveolar hemorrhage10.4
11bardet-biedl syndrome10.2
12rapidly progressive glomerulonephritis10.2
13mesangial proliferative glomerulonephritis10.2
14pharyngitis10.2
15adult syndrome10.2
16n syndrome10.2
17hemolytic-uremic syndrome10.2
18acute proliferative glomerulonephritis10.2
19uremia10.2
20rheumatic disease10.2
21megacystis-megaureter syndrome10.2
22autoimmune hemolytic anemia10.2
23progeria10.2
24kid syndrome10.2
25pertussis10.0CD79A
26purpura10.0CD79A
27stroke, ischemic10.0PF4
28migraine10.0EDNRB
29sinusitis10.0CD79A
30down syndrome10.0EDNRB
31prion disease10.0CD79A
32impetigo10.0SKA2
33meningoencephalitis10.0CD79A
34meningioma10.0EDNRB
35inflammatory bowel disease10.0CD79A
36ankylosing spondylitis10.0CD79A
37pyelonephritis10.0CD79A
38hemangioendothelioma10.0PLG
39hepatitis10.0HP
40bronchiectasis10.0CD79A
41herpes simplex10.0CD79A
42aspergillosis10.0CD79A
43lupus erythematosus10.0CFP, CD79A
44schistosomiasis10.0SERPINF2, CD79A
45allergic rhinitis10.0PF4
46disseminated intravascular coagulation10.0SERPINF2, PF4
47celiac disease10.0CD79A
48colorectal cancer10.0EDNRB, PF4
49dermatitis10.0PF4, CD79A
50protein c deficiency10.0CFP, PLG

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to acute poststreptococcal glomerulonephritis

Clinical Features for Acute Poststreptococcal Glomerulonephritis

Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Acute Poststreptococcal Glomerulonephritis

Drug clinical trials:

Search ClinicalTrials for Acute Poststreptococcal Glomerulonephritis

Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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33MalaCards
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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

33
Spleen, Brain, Skin, Monocytes, T cells

Animal Models for Acute Poststreptococcal Glomerulonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7EDNRB, EDN1, CD79A, HP, PLG, ALB
2MP:00053767.1ALB, CCL2, NPPA, EDNRB, EDN1, CD79A

Publications for Acute Poststreptococcal Glomerulonephritis

Sources:
51PubMed
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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis. (20640906)
2011
2
Localization of nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. (20708459)
2010
3
Elevated plasma levels of N-terminal pro-brain natriuretic peptide in children with acute poststreptococcal glomerulonephritis. (19346734)
2009
4
Sequence and expression of NAPlr is conserved among group A streptococci isolated from patients with acute poststreptococcal glomerulonephritis (APSGN) and non-APSGN. (17557271)
2007
5
Quiz page. Acute rheumatic fever with concomitant poststreptococcal glomerulonephritis. (17687804)
2007
6
Antibodies against four proteins from a Streptococcus pyogenes serotype M1 strain and levels of circulating mannan-binding lectin in acute poststreptococcal glomerulonephritis. (16508336)
2006
7
Poststreptococcal acute glomerulonephritis superimposed on bilateral renal hypoplasia. (15960150)
2005
8
Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis. (15206029)
2004
9
Acute poststreptococcal glomerulonephritis mimicking Henoch-SchAPnlein purpura. (12572934)
2003
10
Another case of acute poststreptococcal glomerulonephritis with recurrence. (12162274)
2002
11
Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions. (11467793)
2001
12
Recurrence of acute poststreptococcal glomerulonephritis. (11465811)
2001
13
Evaluating the use of penicillin to control outbreaks of acute poststreptococcal glomerulonephritis. (10223684)
1999
14
Frequency of microscopic hematuria in acute poststreptococcal glomerulonephritis. (10353421)
1999
15
C3 mesangial proliferative glomerulonephritis--an evaluation of acute poststreptococcal glomerulonephritis? (9518184)
1997
16
Cytokine secretion by peripheral blood monocytes from patients with acute poststreptococcal glomerulonephritis. (7860208)
1994
17
Terminal complement complexes in acute poststreptococcal glomerulonephritis. (7696103)
1994
18
Cell-mediated immune response in acute poststreptococcal glomerulonephritis. (8022104)
1994
19
Etiopathogenesis of acute poststreptococcal glomerulonephritis. (18583766)
1994
20
Myocardial functions of children with acute poststreptococcal glomerulonephritis. (8462203)
1993
21
Wegener's granulomatosis and acute poststreptococcal glomerulonephritis. (8393551)
1993
22
Accelerated decay of the cell bound C4b2a complex by serum of patients with membranoproliferative glomerulonephritis and acute poststreptococcal glomerulonephritis. (1541053)
1992
23
Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. (1996575)
1991
24
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: occurrence in the same patient. (2253249)
1990
25
Decrease in mean platelet survival time in acute poststreptococcal glomerulonephritis (APSGN). (2257699)
1990
26
A case of acute poststreptococcal glomerulonephritis associated with cerebral hemorrhage. (3694896)
1987
27
Children with acute rheumatic fever and acute poststreptococcal glomerulonephritis and their families in a subtropical zone: a three-year prospective comparative epidemiological study. (3440666)
1987
28
High levels of antibodies to streptococcal cell membrane antigens specifically bound to monoclonal antibodies in acute poststreptococcal glomerulonephritis. (3553232)
1987
29
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. (3530567)
1986
30
Detection of IgG-rheumatoid factor in sera of patients with acute poststreptococcal glomerulonephritis and its relationship with circulating immunecomplexes. (3757314)
1986
31
Two cases of acute poststreptococcal glomerulonephritis superimposed on rheumatoid arthritis. (6242205)
1984
32
Suppression of cellular reactivity to group A streptococcal antigens in patients with acute poststreptococcal glomerulonephritis. (6234370)
1984
33
Mendelian recessive ratios in acute poststreptococcal glomerulonephritis. (7128729)
1982
34
Skin window immune response to normal human IgG in patients with rheumatoid arthritis and acute poststreptococcal glomerulonephritis. (7025611)
1981
35
Neuraminidase and free sialic acid levels in acute poststreptococcal glomerulonephritis. (7278916)
1981
36
Neuraminidase activity and free sialic acid levels in the serum of patients with acute poststreptococcal glomerulonephritis. (7231488)
1981
37
Second attack of acute poststreptococcal glomerulonephritis; report of two cases. (524922)
1979
38
Complement components and complement activation in acute poststreptococcal glomerulonephritis. (106018)
1979
39
Irreversible disease following acute poststreptococcal glomerulonephritis in children. (457837)
1979
40
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
41
Does acute poststreptococcal glomerulonephritis lead to chronic renal disease? (628417)
1978
42
Immunopathology of the skin in acute poststreptococcal glomerulonephritis. (581341)
1978
43
Defective phagocyte adherence in acute poststreptococcal glomerulonephritis: clinical and laboratory observations. (978322)
1976
44
Acute, poststreptococcal glomerulonephritis with failure to resolve. (4536431)
1973
45
Acute poststreptococcal glomerulonephritis without proteinuria. Case report. (4701663)
1973
46
Demonstration of antigenic sites in glomeruli of patients with acute poststreptococcal glomerulonephritis by immunofluorescein and immunoferritin technics. (4118883)
1973
47
Experimental streptococcal glomerulonephritis: longitudinal study of a laboratory model resembling human acute poststreptococcal glomerulonephritis. (4101021)
1970
48
A specific antigen and antibody in acute poststreptococcal glomerulonephritis. (4911994)
1969
49
Acute poststreptococcal glomerulonephritis. A case with minimal urinary abnormalities. (5807650)
1969
50
Acute poststreptococcal glomerulonephritis: immune deposit disease. (4159050)
1966

Genetic Variations for Acute Poststreptococcal Glomerulonephritis

Expression for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.7EDNRB
2pge24510.5PF4
3captopril45 29 50 60 1114.4CD79A, EDN1
4pd 1450654510.3EDN1, EDNRB
5sitaxsentan45 2911.3EDNRB, EDN1
6haemaccel4510.3ALB, NPPA
7toki-shakuyaku-san4510.2NPPA, EDN1
8bq12345 2911.1EDN1, EDNRB, NPPA
9bq 302045 2911.1EDN1, EDNRB
10ramipril45 1111.1NPPA, CD79A, ALB
11bq6104510.1EDN1, EDNRB
12phosphoramidon45 1111.1EDNRB, NPPA, EDN1
13spironolactone50 45 60 29 1114.0ALB, EDNRB, NPPA
14cellulose acetate4510.0ALB, HP, CD79A
15probucol45 1111.0HP, EDN1, CCL2
16pd 1428934510.0EDN1, EDNRB
17valsartan45 60 29 1113.0CCL2, EDN1, ALB
18kininogen4510.0SERPINF2, PLG, HP, NPPA
19enalapril45 50 1112.0NPPA, ALB, EDN1
20sulfasalazine45 29 50 1112.9HP, CD79A, CCL2
21ambrisentan45 2910.9EDN1, EDNRB
228-isoprostane459.8CCL2, HP, EDN1
23vitamin b12459.8HP, CD79A, CCL2, ALB
246-ketoprostaglandin f1alpha459.8EDN1, PF4, NPPA, SERPINF2
25oxygen45 2410.7EDNRB, CCL2, SERPINF2, PF4
26hirudin459.7SERPINF2, PF4, CCL2
27verapamil45 50 29 11 2413.7EDNRB, EDN1, CCL2, PF4
28thyroxine45 2410.6CD79A, HP, SERPINF2, ALB
29citrate459.6ALB, HP, CD79A, PF4
30anaphylatoxin459.6PF4, HP, CCL2, CFP, C5
31losartan45 50 29 1112.5ALB, EDN1, NPPA, CCL2, EDNRB
32cyclosporin a45 29 6011.5EDNRB, EDN1, CD79A, HP
33polyethylene glycol459.5ALB, PF4, HP, CD79A, NPPA
34indomethacin45 60 29 1112.5EDN1, EDNRB, CD79A, ALB, PF4
35prostacyclin459.5PF4, EDNRB, NPPA, CCL2, EDN1
36sodium dodecylsulfate459.3HP, SERPINF2, CCL2, ALB, CD79A, NPPA
37polysaccharide459.3SERPINF2, CFP, HP, CD79A, CCL2, PF4
38histamine45 29 2411.3ALB, CD79A, CCL2, EDN1, PF4
39heparin45 29 11 2412.3C4BPA, CD79A, HP, PF4, PLG, CFP
40epinephrine45 11 2411.3PF4, CD79A, HP, NPPA, EDN1, SERPINF2
41testosterone45 60 11 2412.2NPPA, ALB, SERPINF2, HP, CD79A, CCL2
42sodium45 2410.2EDNRB, PF4, EDN1, HP, ALB, NPPA
43arginine459.0PF4, CD79A, EDNRB, NPPA, CCL2, EDN1
44cysteine459.0ALB, EDNRB, CD79A, HP, PF4, PLG
45cholesterol45 29 11 2411.9PF4, SERPINF2, CCL2, C4BPA, HP, ALB
46creatinine458.9CD79A, EDN1, HP, NPPA, CCL2, PF4
47arachidonic acid45 29 11 2411.7HP, EDN1, PF4, ALB, PLG
48fibrinogen458.7C4BPA, CCL2, HP, SERPINF2, PLG, ALB
49vegf458.6EDN1, SERPINF2, PLG, PF4, HP, CD79A
50calcium45 50 11 2411.1PLG, NPPA, C4BPA, EDNRB, ALB, HP

GO Terms for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Sources:
16Gene Ontology
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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2ALB, SERPINF2, PLG, PF4
2spindle microtubuleGO:0058769.0SKA1, SKA3, SKA2
3condensed chromosome outer kinetochoreGO:0009408.7SKA2, SKA3, SKA1
4extracellular spaceGO:0056157.9C5, ALB, SERPINF2, CFP, PLG, PF4
5extracellular regionGO:0055767.4EDN1, ALB, C5, SERPINF2, CFP, PLG

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:01482610.2EDN1, EDNRB
2negative regulation of cellular protein metabolic processGO:03226910.2EDN1, EDNRB
3epithelial fluid transportGO:04204510.2EDN1, EDNRB
4negative regulation of fibrinolysisGO:05191810.1SERPINF2, PLG
5maternal process involved in parturitionGO:06013710.1CCL2, EDN1
6positive regulation of urine volumeGO:03581010.1EDNRB, EDN1
7complement activation, alternative pathwayGO:00695710.0C5, CFP
8vasoconstrictionGO:04231010.0EDN1, EDNRB
9regulation of complement activationGO:03044910.0C5, CFP, C4BPA
10macrophage chemotaxisGO:0482469.9EDNRB, CCL2
11cell surface receptor signaling pathwayGO:0071669.7CCL2, EDNRB, EDN1, C5
12positive regulation of renal sodium excretionGO:0358159.7EDN1, EDNRB
13platelet degranulationGO:0025769.6PF4, PLG, SERPINF2, ALB
14platelet activationGO:0301689.5ALB, SERPINF2, PLG, PF4
15regulation of microtubule polymerization or depolymerizationGO:0311109.3SKA1, SKA3, SKA2
16chromosome segregationGO:0070599.1SKA2, SKA3, SKA1

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.6C5, PF4, CCL2
2protein bindingGO:0055155.2ALB, SFMBT1, C4BPA, EDNRB, EDN1, HP

Products for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Sources for Acute Poststreptococcal Glomerulonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet