MCID: ACT040
MIFTS: 46

Acute Poststreptococcal Glomerulonephritis malady

Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards: Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to glomerulonephritis and rheumatic fever. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (complement factor properdin), and among its related pathways are Activation of C3 and C5 and Dissolution of Fibrin Clot. The compounds norepinephrine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and spleen, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

acute poststreptococcal glomerulonephritis 8 10 44
acute post-streptococcal glomerulonephritis 8 60
post-streptococcal glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:14064
SNOMED-CT56 68544003
NCIt39 C35443

Related Diseases for Acute Poststreptococcal Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.8EDNRB, CCL2, ALB, CFP, CD79A
2rheumatic fever30.8SKA2
3hypertension30.6EDNRB, ALB, PLG, CD79A, NPPA, CCL2
4purpura30.5CD79A
5impetigo30.5SKA2
6rheumatoid arthritis30.5CCL2, CD79A, HP, PF4, PLG
7arthritis30.5CCL2, HP, PLG, ALB
8membranoproliferative glomerulonephritis30.3CD79A, CFP
9pneumonia30.3CD79A, CCL2
10proliferative glomerulonephritis30.3CCL2, CD79A
11sickle cell disease30.3PF4, HP, EDN1
12iga glomerulonephritis30.3CD79A, CFP, ALB, CCL2
13thrombocytopenia30.3PF4, PLG, CD79A, HP, ALB
14membranous glomerulonephritis30.3ALB, CD79A, CCL2, HP
15nephrotic syndrome30.3CD79A, ALB, SERPINF2, HP, NPPA
16proteinuria30.2PLG, CFP, EDNRB, CCL2, EDN1, PF4
17immune-complex glomerulonephritis10.6
18hypertensive encephalopathy10.4
19diffuse glomerulonephritis10.3
20bardet-biedl syndrome10.2
21cerebritis10.2
22wegener's granulomatosis10.2
23rapidly progressive glomerulonephritis10.2
24mesangial proliferative glomerulonephritis10.2
25pharyngitis10.2
26adult syndrome10.2
27hemolytic-uremic syndrome10.2
28acute proliferative glomerulonephritis10.2
29uremia10.2
30autoimmune hemolytic anemia10.2
31progeria10.2
32hemolytic anemia10.2
33kidney disease10.2
34pertussis10.0CD79A
35stroke, ischemic10.0PF4
36migraine10.0EDNRB
37sinusitis10.0CD79A
38down syndrome10.0EDNRB
39prion disease10.0CD79A
40meningoencephalitis10.0CD79A
41meningioma10.0EDNRB
42inflammatory bowel disease10.0CD79A
43ankylosing spondylitis10.0CD79A
44pyelonephritis10.0CD79A
45hemangioendothelioma10.0PLG
46hepatitis10.0HP
47bronchiectasis10.0CD79A
48herpes simplex10.0CD79A
49aspergillosis10.0CD79A
50lupus erythematosus10.0CD79A, CFP

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to acute poststreptococcal glomerulonephritis

Clinical Features for Acute Poststreptococcal Glomerulonephritis

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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

32
Skin, Monocytes, Spleen, Brain, T cells

Animal Models for Acute Poststreptococcal Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7EDNRB, EDN1, CD79A, HP, PLG, ALB
2MP:00053767.1ALB, CCL2, NPPA, EDNRB, EDN1, CD79A

Publications for Acute Poststreptococcal Glomerulonephritis

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50PubMed
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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Elevated plasma levels of N-terminal pro-brain natriuretic peptide in children with acute poststreptococcal glomerulonephritis. (19346734)
2009
2
Co-occurrence of poststreptococcal reactive arthritis and acute glomerulonephritis. (18548195)
2008
3
Antibodies against four proteins from a Streptococcus pyogenes serotype M1 strain and levels of circulating mannan-binding lectin in acute poststreptococcal glomerulonephritis. (16508336)
2006
4
Nephritogenic antigen for acute poststreptococcal glomerulonephritis. (16518356)
2006
5
Glomerular plasmin-like activity in relation to nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. (15574512)
2005
6
Poststreptococcal acute glomerulonephritis superimposed on bilateral renal hypoplasia. (15960150)
2005
7
Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis. (15206029)
2004
8
Acute disseminated encephalomyelitis and poststreptococcal acute glomerulonephritis. (11891098)
2002
9
Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions. (11467793)
2001
10
Acute poststreptococcal glomerulonephritis presenting with hemoptysis. (9686966)
1998
11
Searching for acute poststreptococcal glomerulonephritis-associated Streptococcus pyogenes in Australian aboriginal communities. (9331610)
1997
12
Asymptomatic acute poststreptococcal glomerulonephritis following upper respiratory tract infections caused by Group A streptococci. (8953117)
1996
13
An experimental model for acute poststreptococcal glomerulonephritis in mice. (8982244)
1996
14
Terminal complement complexes in acute poststreptococcal glomerulonephritis. (7696103)
1994
15
Cranial computed tomographic findings in a patient with hypertensive encephalopathy in acute poststreptococcal glomerulonephritis. (7825239)
1994
16
Significance of albuminuria in the follow-up of acute poststreptococcal glomerulonephritis. (8050204)
1994
17
Wegener's granulomatosis and acute poststreptococcal glomerulonephritis. (8393551)
1993
18
Plasma atrial natriuretic peptide and endothelin levels in acute poststreptococcal glomerulonephritis. (1482636)
1992
19
Failure to detect unique reactivity to streptococcal streptokinase in either the sera or renal biopsy specimens of patients with acute poststreptococcal glomerulonephritis. (1468160)
1992
20
Medium- and long-term prognosis of patients with acute poststreptococcal glomerulonephritis. (1922602)
1991
21
Decrease in mean platelet survival time in acute poststreptococcal glomerulonephritis (APSGN). (2257699)
1990
22
A case of acute poststreptococcal glomerulonephritis associated with cerebral hemorrhage. (3694896)
1987
23
Children with acute rheumatic fever and acute poststreptococcal glomerulonephritis and their families in a subtropical zone: a three-year prospective comparative epidemiological study. (3440666)
1987
24
Detection of IgG-rheumatoid factor in sera of patients with acute poststreptococcal glomerulonephritis and its relationship with circulating immunecomplexes. (3757314)
1986
25
Serum immunoglobulins in acute poststreptococcal glomerulonephritis. (4015301)
1985
26
Suppression of cellular reactivity to group A streptococcal antigens in patients with acute poststreptococcal glomerulonephritis. (6234370)
1984
27
Epidemic of acute poststreptococcal glomerulonephritis in aboriginal communities. (6571580)
1983
28
Mendelian recessive ratios in acute poststreptococcal glomerulonephritis. (7128729)
1982
29
Skin window immune response to normal human IgG in patients with rheumatoid arthritis and acute poststreptococcal glomerulonephritis. (7025611)
1981
30
Neuraminidase activity and free sialic acid levels in the serum of patients with acute poststreptococcal glomerulonephritis. (7231488)
1981
31
Characterization of the glomerular antibody in acute poststreptococcal glomerulonephritis. (6965830)
1980
32
Circulating immune complexes in children with acute poststreptococcal glomerulonephritis. (7399865)
1980
33
Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins. (314784)
1979
34
Second attack of acute poststreptococcal glomerulonephritis; report of two cases. (524922)
1979
35
Serum C3 levels in acute poststreptococcal glomerulonephritis. (552189)
1979
36
Complement components and complement activation in acute poststreptococcal glomerulonephritis. (106018)
1979
37
Irreversible disease following acute poststreptococcal glomerulonephritis in children. (457837)
1979
38
Ultrasonic appearance of acute poststreptococcal glomerulonephritis. (416050)
1978
39
Evidence of an autologous immune complex pathogenic mechanism in acute poststreptococcal glomerulonephritis. (750695)
1978
40
Acute poststreptococcal glomerulonephritis mimicking Henoch-SchAPnlein purpura. (690753)
1978
41
Does acute poststreptococcal glomerulonephritis lead to chronic renal disease? (628417)
1978
42
Subarachnoid hemorrhage complicating acute poststreptococcal glomerulonephritis. (666600)
1978
43
Chronic nephritis after acute poststreptococcal glomerulonephritis. (661896)
1978
44
Oral furosemide versus conventional therapy for acute poststreptococcal glomerulonephritis in children. (881593)
1977
45
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
46
Defective phagocyte adherence in acute poststreptococcal glomerulonephritis: clinical and laboratory observations. (978322)
1976
47
Acute poststreptococcal glomerulonephritis without proteinuria. Case report. (4701663)
1973
48
Experimental streptococcal glomerulonephritis: longitudinal study of a laboratory model resembling human acute poststreptococcal glomerulonephritis. (4101021)
1970
49
A specific antigen and antibody in acute poststreptococcal glomerulonephritis. (4911994)
1969
50
Acute poststreptococcal glomerulonephritis. A case with minimal urinary abnormalities. (5807650)
1969

Genetic Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.7EDNRB
2pge24410.5PF4
3captopril44 28 49 59 1114.4CD79A, EDN1
4pd 1450654410.3EDN1, EDNRB
5sitaxsentan44 2811.3EDNRB, EDN1
6haemaccel4410.3ALB, NPPA
7toki-shakuyaku-san4410.2NPPA, EDN1
8bq12344 2811.1EDN1, EDNRB, NPPA
9bq 302044 2811.1EDN1, EDNRB
10ramipril44 1111.1NPPA, CD79A, ALB
11bq6104410.1EDN1, EDNRB
12phosphoramidon44 1111.1EDNRB, NPPA, EDN1
13spironolactone49 44 59 28 1114.0ALB, EDNRB, NPPA
14cellulose acetate4410.0ALB, HP, CD79A
15probucol44 1111.0HP, EDN1, CCL2
16pd 1428934410.0EDN1, EDNRB
17valsartan44 59 28 1113.0CCL2, EDN1, ALB
18kininogen4410.0SERPINF2, PLG, HP, NPPA
19enalapril44 49 1112.0NPPA, ALB, EDN1
20sulfasalazine44 28 49 1112.9HP, CD79A, CCL2
21ambrisentan44 2810.9EDN1, EDNRB
228-isoprostane449.8CCL2, HP, EDN1
23vitamin b12449.8HP, CD79A, CCL2, ALB
246-ketoprostaglandin f1alpha449.8EDN1, PF4, NPPA, SERPINF2
25oxygen44 2410.7EDNRB, CCL2, SERPINF2, PF4
26hirudin449.7SERPINF2, PF4, CCL2
27verapamil44 49 28 11 2413.7EDNRB, EDN1, CCL2, PF4
28thyroxine44 2410.6CD79A, HP, SERPINF2, ALB
29citrate449.6ALB, HP, CD79A, PF4
30anaphylatoxin449.6PF4, HP, CCL2, CFP, C5
31losartan44 49 28 1112.5ALB, EDN1, NPPA, CCL2, EDNRB
32cyclosporin a44 28 5911.5EDNRB, EDN1, CD79A, HP
33polyethylene glycol449.5ALB, PF4, HP, CD79A, NPPA
34indomethacin44 59 28 1112.5EDN1, EDNRB, CD79A, ALB, PF4
35prostacyclin449.5PF4, EDNRB, NPPA, CCL2, EDN1
36sodium dodecylsulfate449.3HP, SERPINF2, CCL2, ALB, CD79A, NPPA
37polysaccharide449.3SERPINF2, CFP, HP, CD79A, CCL2, PF4
38histamine44 28 2411.3ALB, CD79A, CCL2, EDN1, PF4
39heparin44 28 11 2412.3C4BPA, CD79A, HP, PF4, PLG, CFP
40epinephrine44 11 2411.3PF4, CD79A, HP, NPPA, EDN1, SERPINF2
41testosterone44 59 11 2412.2NPPA, ALB, SERPINF2, HP, CD79A, CCL2
42sodium44 2410.2EDNRB, PF4, EDN1, HP, ALB, NPPA
43arginine449.0PF4, CD79A, EDNRB, NPPA, CCL2, EDN1
44cysteine449.0ALB, EDNRB, CD79A, HP, PF4, PLG
45cholesterol44 28 11 2411.9PF4, SERPINF2, CCL2, C4BPA, HP, ALB
46creatinine448.9CD79A, EDN1, HP, NPPA, CCL2, PF4
47arachidonic acid44 28 11 2411.7HP, EDN1, PF4, ALB, PLG
48fibrinogen448.7C4BPA, CCL2, HP, SERPINF2, PLG, ALB
49vegf448.6EDN1, SERPINF2, PLG, PF4, HP, CD79A
50calcium44 49 11 2411.1PLG, NPPA, C4BPA, EDNRB, ALB, HP

GO Terms for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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16Gene Ontology
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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2PF4, PLG, SERPINF2, ALB
2spindle microtubuleGO:0058769.0SKA1, SKA3, SKA2
3condensed chromosome outer kinetochoreGO:0009408.7SKA1, SKA3, SKA2
4extracellular spaceGO:0056157.9ALB, CCL2, NPPA, EDN1, HP, PF4
5extracellular regionGO:0055767.4CCL2, NPPA, C4BPA, EDN1, HP, PF4

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:01482610.2EDN1, EDNRB
2negative regulation of cellular protein metabolic processGO:03226910.2EDN1, EDNRB
3epithelial fluid transportGO:04204510.2EDN1, EDNRB
4negative regulation of fibrinolysisGO:05191810.1SERPINF2, PLG
5maternal process involved in parturitionGO:06013710.1CCL2, EDN1
6positive regulation of urine volumeGO:03581010.1EDNRB, EDN1
7complement activation, alternative pathwayGO:00695710.0C5, CFP
8vasoconstrictionGO:04231010.0EDN1, EDNRB
9regulation of complement activationGO:03044910.0C5, CFP, C4BPA
10macrophage chemotaxisGO:0482469.9EDNRB, CCL2
11cell surface receptor signaling pathwayGO:0071669.7CCL2, EDNRB, EDN1, C5
12positive regulation of renal sodium excretionGO:0358159.7EDN1, EDNRB
13platelet degranulationGO:0025769.6PF4, PLG, SERPINF2, ALB
14platelet activationGO:0301689.5ALB, SERPINF2, PLG, PF4
15regulation of microtubule polymerization or depolymerizationGO:0311109.3SKA1, SKA3, SKA2
16chromosome segregationGO:0070599.1SKA2, SKA3, SKA1

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.6C5, PF4, CCL2
2protein bindingGO:0055155.2ALB, SFMBT1, C4BPA, EDNRB, EDN1, HP

Products for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Sources for Acute Poststreptococcal Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
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57SNOMED-CT via Orphanet
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