MCID: ACT040
MIFTS: 46

Acute Poststreptococcal Glomerulonephritis malady

Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards: Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to glomerulonephritis and rheumatic fever. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (complement factor properdin), and among its related pathways are Activation of C3 and C5 and Dissolution of Fibrin Clot. The compounds norepinephrine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and spleen, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

acute poststreptococcal glomerulonephritis 8 10 44
acute post-streptococcal glomerulonephritis 8 60
post-streptococcal glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:14064
SNOMED-CT56 68544003
NCIt39 C35443

Related Diseases for Acute Poststreptococcal Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.8EDNRB, CCL2, ALB, CFP, CD79A
2rheumatic fever30.8SKA2
3hypertension30.6EDNRB, ALB, PLG, CD79A, NPPA, CCL2
4purpura30.5CD79A
5impetigo30.5SKA2
6rheumatoid arthritis30.5CCL2, CD79A, HP, PF4, PLG
7arthritis30.5CCL2, HP, PLG, ALB
8membranoproliferative glomerulonephritis30.3CD79A, CFP
9pneumonia30.3CD79A, CCL2
10proliferative glomerulonephritis30.3CCL2, CD79A
11sickle cell disease30.3PF4, HP, EDN1
12iga glomerulonephritis30.3CD79A, CFP, ALB, CCL2
13thrombocytopenia30.3PF4, PLG, CD79A, HP, ALB
14membranous glomerulonephritis30.3ALB, CD79A, CCL2, HP
15nephrotic syndrome30.3CD79A, ALB, SERPINF2, HP, NPPA
16proteinuria30.2PLG, CFP, EDNRB, CCL2, EDN1, PF4
17immune-complex glomerulonephritis10.6
18hypertensive encephalopathy10.4
19diffuse glomerulonephritis10.3
20bardet-biedl syndrome10.2
21cerebritis10.2
22wegener's granulomatosis10.2
23rapidly progressive glomerulonephritis10.2
24mesangial proliferative glomerulonephritis10.2
25pharyngitis10.2
26adult syndrome10.2
27hemolytic-uremic syndrome10.2
28acute proliferative glomerulonephritis10.2
29uremia10.2
30autoimmune hemolytic anemia10.2
31progeria10.2
32hemolytic anemia10.2
33kidney disease10.2
34pertussis10.0CD79A
35stroke, ischemic10.0PF4
36migraine10.0EDNRB
37sinusitis10.0CD79A
38down syndrome10.0EDNRB
39prion disease10.0CD79A
40meningoencephalitis10.0CD79A
41meningioma10.0EDNRB
42inflammatory bowel disease10.0CD79A
43ankylosing spondylitis10.0CD79A
44pyelonephritis10.0CD79A
45hemangioendothelioma10.0PLG
46hepatitis10.0HP
47bronchiectasis10.0CD79A
48herpes simplex10.0CD79A
49aspergillosis10.0CD79A
50lupus erythematosus10.0CD79A, CFP

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to acute poststreptococcal glomerulonephritis

Clinical Features for Acute Poststreptococcal Glomerulonephritis

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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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32MalaCards
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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

32
Skin, Monocytes, Spleen, Brain, T cells

Animal Models for Acute Poststreptococcal Glomerulonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7EDNRB, EDN1, CD79A, HP, PLG, ALB
2MP:00053767.1ALB, CCL2, NPPA, EDNRB, EDN1, CD79A

Publications for Acute Poststreptococcal Glomerulonephritis

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50PubMed
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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
A case of BehAset's disease developing after poststreptococcal acute glomerulonephritis. (22933309)
2013
2
Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome. (22891230)
2012
3
Unfavorable outcome in a child with megaureter-megacystis syndrome complicated by mild acute poststreptococcal glomerulonephritis. (21166952)
2010
4
Concomitant severe normocytic and normochromic anemia in poststreptococcal acute glomerulonephritis. (19915313)
2009
5
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. (19095947)
2009
6
Acute poststreptococcal glomerulonephritis superimposed on IgA nephropathy. (18793531)
2008
7
Elevated urinary plasmin activity resistant to alpha2-antiplasmin in acute poststreptococcal glomerulonephritis. (18223261)
2008
8
An adult with acute poststreptococcal glomerulonephritis complicated by hemolytic uremic syndrome and nephrotic syndrome. (16183409)
2005
9
Glomerular plasmin-like activity in relation to nephritis-associated plasmin receptor in acute poststreptococcal glomerulonephritis. (15574512)
2005
10
Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. (15213266)
2004
11
Acute poststreptococcal glomerulonephritis and acute rheumatic fever in the same patient: a case report and review of the literature. (12967898)
2003
12
Thrombocytopenia during the course of acute poststreptococcal glomerulonephritis. (12921303)
2003
13
Acute disseminated encephalomyelitis and poststreptococcal acute glomerulonephritis. (11891098)
2002
14
Prognosis of acute poststreptococcal glomerulonephritis (APSGN) is excellent in children, when adequately diagnosed. (11472580)
2001
15
Acute poststreptococcal glomerulonephritis associated with thrombotic microangiopathy in an adult. (10968697)
2000
16
Renal function during and after childhood acute poststreptococcal glomerulonephritis. (10603146)
1999
17
Acute poststreptococcal glomerulonephritis presenting with hemoptysis. (9686966)
1998
18
Regulation of the C3 production by gamma interferon from peripheral blood T cells in patients with membranoproliferative glomerulonephritis and poststreptococcal acute glomerulonephritis. (8730432)
1996
19
Asymptomatic acute poststreptococcal glomerulonephritis following upper respiratory tract infections caused by Group A streptococci. (8953117)
1996
20
Myocardial dysfunction in a 23-month child with acute poststreptococcal glomerulonephritis. (7793601)
1995
21
Cranial computed tomographic findings in a patient with hypertensive encephalopathy in acute poststreptococcal glomerulonephritis. (7825239)
1994
22
Plasma atrial natriuretic peptide and endothelin levels in acute poststreptococcal glomerulonephritis. (1482636)
1992
23
Failure to detect unique reactivity to streptococcal streptokinase in either the sera or renal biopsy specimens of patients with acute poststreptococcal glomerulonephritis. (1468160)
1992
24
Role of a streptococcal antigen in the pathogenesis of acute poststreptococcal glomerulonephritis. Characterization of the antigen and a proposed mechanism for the disease. (1578137)
1992
25
Medium- and long-term prognosis of patients with acute poststreptococcal glomerulonephritis. (1922602)
1991
26
Natriuretic response to i.v. saline loading after acute poststreptococcal glomerulonephritis. (3793435)
1986
27
Glomerular binding sites for peanut agglutinin in acute poststreptococcal glomerulonephritis. (3542320)
1986
28
Acute poststreptococcal glomerulonephritis progressing to rapidly progressive glomerulonephritis. (6494975)
1984
29
Circulating immune complexes in patients with uncomplicated group A streptococcal pharyngitis and patients with acute poststreptococcal glomerulonephritis. (6340506)
1983
30
Epidemic of acute poststreptococcal glomerulonephritis in aboriginal communities. (6571580)
1983
31
Acute poststreptococcal glomerulonephritis. (6918833)
1982
32
Characterization of the glomerular antibody in acute poststreptococcal glomerulonephritis. (6965830)
1980
33
Circulating immune complexes in children with acute poststreptococcal glomerulonephritis. (7399865)
1980
34
Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins. (314784)
1979
35
Acute poststreptococcal glomerulonephritis. A review of recent developments. (392405)
1979
36
HLA and acute poststreptococcal glomerulonephritis. (114834)
1979
37
Evidence of an autologous immune complex pathogenic mechanism in acute poststreptococcal glomerulonephritis. (750695)
1978
38
Acute poststreptococcal glomerulonephritis mimicking Henoch-SchAPnlein purpura. (690753)
1978
39
Subarachnoid hemorrhage complicating acute poststreptococcal glomerulonephritis. (666600)
1978
40
Chronic nephritis after acute poststreptococcal glomerulonephritis. (661896)
1978
41
Oral furosemide versus conventional therapy for acute poststreptococcal glomerulonephritis in children. (881593)
1977
42
Necrotizing arteritis in acute poststreptococcal glomerulonephritis: report of a recovered case. (17662)
1977
43
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
44
Prognosis of acute poststreptococcal glomerulonephritis in childhood: prospective study and review of the literature. (1008003)
1976
45
A hitherto unknown streptococcal antigen and its probable relation to acute poststreptococcal glomerulonephritis. (820502)
1976
46
Acute poststreptococcal glomerulonephritis. (136630)
1976
47
Intravenous diazoxide in acute poststreptococcal glomerulonephritis. (1185352)
1975
48
Acute poststreptococcal glomerulonephritis. A retrospective study. (4752192)
1973
49
Natural history of "apparently healed" acute poststreptococcal glomerulonephritis in children. (4891762)
1969
50
Acute poststreptococcal glomerulonephritis presenting as hypertensive encephalopathy with minimal urinary abnormalities. (6018971)
1967

Genetic Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.7EDNRB
2pge24410.5PF4
3captopril44 28 49 59 1114.4CD79A, EDN1
4pd 1450654410.3EDN1, EDNRB
5sitaxsentan44 2811.3EDNRB, EDN1
6haemaccel4410.3ALB, NPPA
7toki-shakuyaku-san4410.2NPPA, EDN1
8bq12344 2811.1EDN1, EDNRB, NPPA
9bq 302044 2811.1EDN1, EDNRB
10ramipril44 1111.1NPPA, CD79A, ALB
11bq6104410.1EDN1, EDNRB
12phosphoramidon44 1111.1EDNRB, NPPA, EDN1
13spironolactone49 44 59 28 1114.0ALB, EDNRB, NPPA
14cellulose acetate4410.0ALB, HP, CD79A
15probucol44 1111.0HP, EDN1, CCL2
16pd 1428934410.0EDN1, EDNRB
17valsartan44 59 28 1113.0CCL2, EDN1, ALB
18kininogen4410.0SERPINF2, PLG, HP, NPPA
19enalapril44 49 1112.0NPPA, ALB, EDN1
20sulfasalazine44 28 49 1112.9HP, CD79A, CCL2
21ambrisentan44 2810.9EDN1, EDNRB
228-isoprostane449.8CCL2, HP, EDN1
23vitamin b12449.8HP, CD79A, CCL2, ALB
246-ketoprostaglandin f1alpha449.8EDN1, PF4, NPPA, SERPINF2
25oxygen44 2410.7EDNRB, CCL2, SERPINF2, PF4
26hirudin449.7SERPINF2, PF4, CCL2
27verapamil44 49 28 11 2413.7EDNRB, EDN1, CCL2, PF4
28thyroxine44 2410.6CD79A, HP, SERPINF2, ALB
29citrate449.6ALB, HP, CD79A, PF4
30anaphylatoxin449.6PF4, HP, CCL2, CFP, C5
31losartan44 49 28 1112.5ALB, EDN1, NPPA, CCL2, EDNRB
32cyclosporin a44 28 5911.5EDNRB, EDN1, CD79A, HP
33polyethylene glycol449.5ALB, PF4, HP, CD79A, NPPA
34indomethacin44 59 28 1112.5EDN1, EDNRB, CD79A, ALB, PF4
35prostacyclin449.5PF4, EDNRB, NPPA, CCL2, EDN1
36sodium dodecylsulfate449.3HP, SERPINF2, CCL2, ALB, CD79A, NPPA
37polysaccharide449.3SERPINF2, CFP, HP, CD79A, CCL2, PF4
38histamine44 28 2411.3ALB, CD79A, CCL2, EDN1, PF4
39heparin44 28 11 2412.3C4BPA, CD79A, HP, PF4, PLG, CFP
40epinephrine44 11 2411.3PF4, CD79A, HP, NPPA, EDN1, SERPINF2
41testosterone44 59 11 2412.2NPPA, ALB, SERPINF2, HP, CD79A, CCL2
42sodium44 2410.2EDNRB, PF4, EDN1, HP, ALB, NPPA
43arginine449.0PF4, CD79A, EDNRB, NPPA, CCL2, EDN1
44cysteine449.0ALB, EDNRB, CD79A, HP, PF4, PLG
45cholesterol44 28 11 2411.9PF4, SERPINF2, CCL2, C4BPA, HP, ALB
46creatinine448.9CD79A, EDN1, HP, NPPA, CCL2, PF4
47arachidonic acid44 28 11 2411.7HP, EDN1, PF4, ALB, PLG
48fibrinogen448.7C4BPA, CCL2, HP, SERPINF2, PLG, ALB
49vegf448.6EDN1, SERPINF2, PLG, PF4, HP, CD79A
50calcium44 49 11 2411.1PLG, NPPA, C4BPA, EDNRB, ALB, HP

GO Terms for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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16Gene Ontology
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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2PF4, PLG, SERPINF2, ALB
2spindle microtubuleGO:0058769.0SKA1, SKA3, SKA2
3condensed chromosome outer kinetochoreGO:0009408.7SKA1, SKA3, SKA2
4extracellular spaceGO:0056157.9ALB, CCL2, NPPA, EDN1, HP, PF4
5extracellular regionGO:0055767.4CCL2, NPPA, C4BPA, EDN1, HP, PF4

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1vein smooth muscle contractionGO:01482610.2EDN1, EDNRB
2negative regulation of cellular protein metabolic processGO:03226910.2EDN1, EDNRB
3epithelial fluid transportGO:04204510.2EDN1, EDNRB
4negative regulation of fibrinolysisGO:05191810.1SERPINF2, PLG
5maternal process involved in parturitionGO:06013710.1CCL2, EDN1
6positive regulation of urine volumeGO:03581010.1EDNRB, EDN1
7complement activation, alternative pathwayGO:00695710.0C5, CFP
8vasoconstrictionGO:04231010.0EDN1, EDNRB
9regulation of complement activationGO:03044910.0C5, CFP, C4BPA
10macrophage chemotaxisGO:0482469.9EDNRB, CCL2
11cell surface receptor signaling pathwayGO:0071669.7CCL2, EDNRB, EDN1, C5
12positive regulation of renal sodium excretionGO:0358159.7EDN1, EDNRB
13platelet degranulationGO:0025769.6PF4, PLG, SERPINF2, ALB
14platelet activationGO:0301689.5ALB, SERPINF2, PLG, PF4
15regulation of microtubule polymerization or depolymerizationGO:0311109.3SKA1, SKA3, SKA2
16chromosome segregationGO:0070599.1SKA2, SKA3, SKA1

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.6C5, PF4, CCL2
2protein bindingGO:0055155.2ALB, SFMBT1, C4BPA, EDNRB, EDN1, HP

Products for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Sources for Acute Poststreptococcal Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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40NDF-RT
43NINDS
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47OMIM via Orphanet
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