MCID: ACT040
MIFTS: 49

Acute Poststreptococcal Glomerulonephritis malady

Nephrological diseases category
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Summaries for Acute Poststreptococcal Glomerulonephritis

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33MalaCards
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MalaCards: Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to glomerulonephritis and nephritis. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (complement factor properdin), and among its related pathways are Dissolution of Fibrin Clot and Prostaglandin Synthesis and Regulation. The compounds haemaccel and bq123 have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and spleen, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

acute poststreptococcal glomerulonephritis 8 10 45
acute post-streptococcal glomerulonephritis 8 62
post-streptococcal glomerulonephritis 8


External Ids:

Disease Ontology8 DOID:14064
SNOMED-CT58 68544003
NCIt40 C35443

Related Diseases for Acute Poststreptococcal Glomerulonephritis

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17GeneCards, 18GeneDecks
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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.9CD79A, CCL2, CFP, EDNRB, ALB
2nephritis30.9ALB, CD79A, CCL2, CFP
3impetigo30.8SKA2
4rheumatoid arthritis30.5HP, CCL2, PF4, CD79A, PLG
5membranoproliferative glomerulonephritis30.5CFP, CD79A
6arthritis30.5PLG, ALB, HP, CCL2
7proliferative glomerulonephritis30.5CCL2, CD79A
8hypertension30.5PLG, CCL2, NPPA, CD79A, EDN1, EDNRB
9autoimmune hemolytic anemia30.4HP, CD79A
10sickle cell disease30.4PF4, EDN1, HP
11thrombocytopenia30.3PF4, HP, PLG, ALB, CD79A
12nephrotic syndrome30.3SERPINF2, ALB, HP, NPPA, CD79A
13proteinuria30.0CD79A, ALB, HP, CCL2, PF4, CFP
14rheumatic fever10.5
15hypertensive encephalopathy10.4
16purpura10.4
17diffuse alveolar hemorrhage10.4
18bardet-biedl syndrome10.2
19pharyngitis10.2
20hemolytic-uremic syndrome10.2
21cerebritis10.2
22wegener's granulomatosis10.2
23rapidly progressive glomerulonephritis10.2
24mesangial proliferative glomerulonephritis10.2
25pneumonia10.2
26uremia10.2
27hemolytic anemia10.2
28kidney disease10.2
29meningoencephalitis10.1CD79A
30pyelonephritis10.1CD79A
31intermediate coronary syndrome10.1PLG
32sepsis10.1SERPINF2, CFP
33protein-losing enteropathy10.1ALB
34hemorrhagic disease10.1SERPINF2, PF4
35hyperthyroxinemia10.1ALB
36complement deficiency10.1C5, CFP
37immunoglobulin alpha deficiency10.1CD79A, HP
38agammaglobulinemia10.1CFP, CD79A
39corneal neovascularization10.1PLG, PF4
40septic shock10.1CFP, PF4, C4BPA
41conjunctivitis10.1PLG, CD79A
42reactive arthritis10.1CD79A, HP
43mitral valve stenosis10.1NPPA, PF4
44protein c deficiency10.1CFP, PLG
45cholangitis10.1ALB
46peripheral vascular disease10.1PF4, ALB
47thrombocytosis10.1SERPINF2, HP, PF4
48thrombophilia10.1PLG, SERPINF2, PF4
49thromboembolism10.1SERPINF2, PF4, PLG
50low renin hypertension10.1EDN1

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to acute poststreptococcal glomerulonephritis

Symptoms for Acute Poststreptococcal Glomerulonephritis

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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Acute Poststreptococcal Glomerulonephritis

Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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33MalaCards
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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

33
Skin, Monocytes, Spleen, Brain

Animal Models for Acute Poststreptococcal Glomerulonephritis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ALB, PLG, HP, CCL2, EDNRB
2MP:00053878.6CD79A, C5, PLG, HP, CCL2, CFP
3MP:00053858.4EDN1, NPPA, EDNRB, CFP, CCL2, HP
4MP:00053678.4CD79A, NPPA, EDNRB, ALB, PLG, HP
5MP:00028738.3C5, ALB, CD79A, CFP, EDN1, CCL2
6MP:00053766.9ALB, HP, C5, NPPA, CD79A, CCL2

Publications for Acute Poststreptococcal Glomerulonephritis

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52PubMed
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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome. (22891230)
2012
2
Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis. (20640906)
2011
3
Elevated plasma levels of N-terminal pro-brain natriuretic peptide in children with acute poststreptococcal glomerulonephritis. (19346734)
2009
4
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. (19095947)
2009
5
Acute poststreptococcal glomerulonephritis superimposed on IgA nephropathy. (18793531)
2008
6
Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis. (15206029)
2004
7
Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. (12654066)
2003
8
Acute poststreptococcal glomerulonephritis and acute rheumatic fever in the same patient: a case report and review of the literature. (12967898)
2003
9
Thrombocytopenia during the course of acute poststreptococcal glomerulonephritis. (12921303)
2003
10
Acute poststreptococcal glomerulonephritis in a child with Bardet-Biedl syndrome. (11793138)
2002
11
Another case of acute poststreptococcal glomerulonephritis with recurrence. (12162274)
2002
12
Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions. (11467793)
2001
13
Acute poststreptococcal glomerulonephritis following circumcision. (11149125)
2000
14
Evaluating the use of penicillin to control outbreaks of acute poststreptococcal glomerulonephritis. (10223684)
1999
15
Renal function during and after childhood acute poststreptococcal glomerulonephritis. (10603146)
1999
16
Acute poststreptococcal glomerulonephritis presenting with hemoptysis. (9686966)
1998
17
Searching for acute poststreptococcal glomerulonephritis-associated Streptococcus pyogenes in Australian aboriginal communities. (9331610)
1997
18
Myocardial dysfunction in a 23-month child with acute poststreptococcal glomerulonephritis. (7793601)
1995
19
Cytokine secretion by peripheral blood monocytes from patients with acute poststreptococcal glomerulonephritis. (7860208)
1994
20
Terminal complement complexes in acute poststreptococcal glomerulonephritis. (7696103)
1994
21
Cell-mediated immune response in acute poststreptococcal glomerulonephritis. (8022104)
1994
22
Plasma atrial natriuretic peptide and endothelin levels in acute poststreptococcal glomerulonephritis. (1482636)
1992
23
Failure to detect unique reactivity to streptococcal streptokinase in either the sera or renal biopsy specimens of patients with acute poststreptococcal glomerulonephritis. (1468160)
1992
24
Role of a streptococcal antigen in the pathogenesis of acute poststreptococcal glomerulonephritis. Characterization of the antigen and a proposed mechanism for the disease. (1578137)
1992
25
Medium- and long-term prognosis of patients with acute poststreptococcal glomerulonephritis. (1922602)
1991
26
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: occurrence in the same patient. (2253249)
1990
27
A case of acute poststreptococcal glomerulonephritis associated with cerebral hemorrhage. (3694896)
1987
28
Children with acute rheumatic fever and acute poststreptococcal glomerulonephritis and their families in a subtropical zone: a three-year prospective comparative epidemiological study. (3440666)
1987
29
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. (3530567)
1986
30
Two cases of acute poststreptococcal glomerulonephritis superimposed on rheumatoid arthritis. (6242205)
1984
31
Acute poststreptococcal glomerulonephritis progressing to rapidly progressive glomerulonephritis. (6494975)
1984
32
Suppression of cellular reactivity to group A streptococcal antigens in patients with acute poststreptococcal glomerulonephritis. (6234370)
1984
33
Mendelian recessive ratios in acute poststreptococcal glomerulonephritis. (7128729)
1982
34
Characterization of the glomerular antibody in acute poststreptococcal glomerulonephritis. (6965830)
1980
35
Acute poststreptococcal glomerulonephritis in pregnancy: case report with an 18-year follow-up. (7405978)
1980
36
Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins. (314784)
1979
37
Second attack of acute poststreptococcal glomerulonephritis; report of two cases. (524922)
1979
38
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
39
Ultrasonic appearance of acute poststreptococcal glomerulonephritis. (416050)
1978
40
Evidence of an autologous immune complex pathogenic mechanism in acute poststreptococcal glomerulonephritis. (750695)
1978
41
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
42
Immune deposits in the spleen of a patient with acute poststreptococcal glomerulonephritis (APSGN). (975639)
1976
43
Defective phagocyte adherence in acute poststreptococcal glomerulonephritis: clinical and laboratory observations. (978322)
1976
44
The fate of subepithelial deposits in acute poststreptococcal glomerulonephritis. (792564)
1976
45
Acute, poststreptococcal glomerulonephritis with failure to resolve. (4536431)
1973
46
Acute poststreptococcal glomerulonephritis. A retrospective study. (4752192)
1973
47
Editorial: Acute poststreptococcal glomerulonephritis. Mechanism and sequelae--attempts at a unifying concept. (4593114)
1972
48
A specific antigen and antibody in acute poststreptococcal glomerulonephritis. (4911994)
1969
49
Acute poststreptococcal glomerulonephritis. A case with minimal urinary abnormalities. (5807650)
1969
50
Acute poststreptococcal glomerulonephritis: immune deposit disease. (4159050)
1966

Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 57SinoBiological, 54R&D Systems, 30KEGG
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Pathways related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLG, SERPINF2
29.9EDN1, EDNRB
3
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.8C4BPA, C5, CFP
4
Show member pathways
9.5SERPINF2, PF4, PLG
5
Show member pathways
thioredoxin pathway38
9.4CCL2, PLG, ALB
6
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.4C4BPA, C5, PLG, SERPINF2
7
Show member pathways
9.4C5, PLG, CCL2, CFP
8
Show member pathways
9.1SERPINF2, PF4, PLG, ALB
9
Show member pathways
9.1SERPINF2, PF4, PLG, ALB
10
Show member pathways
8.5EDNRB, EDN1, PF4, CCL2, PLG, C5
11
Show member pathways
8.5EDNRB, EDN1, PF4, CCL2, PLG, C5

Compounds for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB
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Compounds related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1haemaccel4510.1ALB, NPPA
2bq12345 2911.0EDNRB, EDN1, NPPA
3ramipril45 1110.9CD79A, NPPA, ALB
4phosphoramidon45 1110.8EDNRB, EDN1, NPPA
5cellulose acetate459.8CD79A, HP, ALB
6probucol45 1110.8CCL2, HP, EDN1
7spironolactone45 61 29 51 1113.8NPPA, ALB, EDNRB
8toki-shakuyaku-san459.8NPPA, EDN1
9sulfasalazine29 45 51 1112.8CD79A, CCL2, HP
10sitaxsentan45 2910.8EDNRB, EDN1
11valsartan45 61 29 1112.7EDN1, CCL2, ALB
12irbesartan45 29 51 1112.7ALB, EDN1, CCL2
13enalapril45 51 1111.7NPPA, ALB, EDN1
14vitamin b12459.6CD79A, CCL2, ALB, HP
158-isoprostane459.6EDN1, CCL2, HP
16pd 145065459.6EDNRB, EDN1
17thyroxine45 2410.5ALB, HP, CD79A, SERPINF2
186-ketoprostaglandin f1alpha459.5PF4, SERPINF2, NPPA, EDN1
19citrate459.4ALB, CD79A, HP, PF4
20hirudin459.4CCL2, PF4, SERPINF2
21verapamil45 29 51 24 1113.4PF4, CCL2, EDN1, EDNRB
22anaphylatoxin459.4HP, PF4, CFP, CCL2, C5
23captopril45 61 51 29 1113.3EDN1, ALB, PLG, NPPA, CD79A
24cyclosporin a45 29 6111.2EDNRB, NPPA, EDN1, CD79A, HP
25losartan45 51 29 1112.2NPPA, EDNRB, EDN1, CCL2, ALB
26polyethylene glycol459.2HP, PF4, NPPA, CD79A, ALB
27indomethacin45 29 61 1112.2CD79A, EDNRB, EDN1, PF4, ALB
28prostacyclin459.2NPPA, CCL2, EDN1, EDNRB, PF4
29polysaccharide459.1HP, CD79A, PF4, SERPINF2, CFP, CCL2
30sodium dodecylsulfate459.1ALB, CCL2, HP, NPPA, CD79A, SERPINF2
31histamine45 29 2411.0CD79A, PF4, EDN1, CCL2, ALB
32testosterone45 61 24 1112.0NPPA, ALB, SERPINF2, CCL2, HP, CD79A
33epinephrine45 24 1111.0EDN1, PF4, HP, NPPA, CD79A, SERPINF2
34norepinephrine45 24 1110.9CD79A, CCL2, NPPA, EDN1, PF4, EDNRB
35arachidonic acid45 29 24 1111.9HP, EDN1, PLG, PF4, ALB
36lactate458.9HP, PF4, CD79A, ALB, C4BPA
37kininogen458.9NPPA, PF4, ALB, PLG, SERPINF2, HP
38nitric oxide45 24 1110.8EDNRB, NPPA, HP, PLG, CCL2, EDN1
39cholesterol45 29 24 1111.8HP, ALB, SERPINF2, PF4, CCL2, C4BPA
40alanine458.8PF4, SERPINF2, HP, EDNRB, CD79A, ALB
41sodium45 249.8EDN1, PF4, HP, ALB, NPPA, EDNRB
42cysteine458.7CFP, PF4, HP, EDNRB, ALB, PLG
43pge2458.7EDNRB, EDN1, HP, PF4, CCL2, CD79A
44arginine458.7CCL2, NPPA, CD79A, SERPINF2, EDN1, EDNRB
45oxygen45 249.6PF4, EDN1, NPPA, PLG, CCL2, EDNRB
46heparin45 29 24 1111.5CFP, C4BPA, CD79A, SERPINF2, ALB, PLG
47creatinine458.5ALB, HP, CCL2, PF4, NPPA, EDN1
48fibrinogen458.4PF4, HP, C4BPA, CD79A, ALB, PLG
49vegf458.1NPPA, EDN1, SERPINF2, PF4, CCL2, HP
50calcium45 51 24 1110.7EDNRB, EDN1, SERPINF2, NPPA, C4BPA, CCL2

GO Terms for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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16Gene Ontology
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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.0SERPINF2, HP, PLG, ALB, C4BPA
2platelet alpha granule lumenGO:0310939.0SERPINF2, PF4, PLG, ALB
3spindle microtubuleGO:0058768.5SKA2, SKA1, SKA3
4condensed chromosome outer kinetochoreGO:0009408.2SKA2, SKA1, SKA3
5extracellular spaceGO:0056157.3PF4, SERPINF2, CFP, EDN1, CCL2, HP
6extracellular regionGO:0055767.1C4BPA, EDN1, CFP, SERPINF2, PF4, CCL2

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00695710.3C5, CFP
2epithelial fluid transportGO:04204510.2EDNRB, EDN1
3negative regulation of fibrinolysisGO:05191810.2SERPINF2, PLG
4negative regulation of cellular protein metabolic processGO:03226910.2EDNRB, EDN1
5vein smooth muscle contractionGO:01482610.2EDNRB, EDN1
6macrophage chemotaxisGO:04824610.1EDNRB, CCL2
7positive regulation of urine volumeGO:03581010.1EDN1, EDNRB
8regulation of complement activationGO:03044910.1CFP, C5, C4BPA
9positive regulation of renal sodium excretionGO:03581510.1EDNRB, EDN1
10fibrinolysisGO:04273010.1PLG, SERPINF2
11vasoconstrictionGO:04231010.0EDN1, EDNRB
12maternal process involved in parturitionGO:06013710.0CCL2, EDN1
13regulation of pHGO:00688510.0EDNRB, EDN1
14response to organic substanceGO:0100339.8ALB, SERPINF2
15regulation of sensory perception of painGO:0519309.8EDN1, EDNRB
16cell surface receptor signaling pathwayGO:0071669.6C5, CCL2, EDN1, EDNRB
17response to amino acidGO:0432009.5CCL2, EDN1
18response to hypoxiaGO:0016669.4EDN1, CCL2, NPPA
19platelet degranulationGO:0025769.4ALB, PLG, PF4, SERPINF2
20platelet activationGO:0301689.4SERPINF2, PF4, PLG, ALB
21blood coagulationGO:0075969.1ALB, PLG, PF4, SERPINF2
22regulation of microtubule polymerization or depolymerizationGO:0311108.9SKA2, SKA1, SKA3
23chromosome segregationGO:0070598.8SKA2, SKA1, SKA3

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.8ALB, HP
2chemokine activityGO:0080099.1PF4, CCL2, C5
3protein bindingGO:0055155.5C4BPA, EDNRB, EDN1, SFMBT1, SERPINF2, HP

Products for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Sources for Acute Poststreptococcal Glomerulonephritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet