Acute Poststreptococcal Glomerulonephritis malady

MalaCards: Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis (disorder), is related to impetigo and hemolytic-uremic syndrome. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (complement factor properdin), and among its related pathways are Complement and coagulation cascades and Endothelin-1 Signaling Pathway. The compounds testosterone and citrate have been mentioned in the context of this disorder. Affiliated tissues include monocytes, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Descriptions:

acute poststreptococcal glomerulonephritis 6 8 32 acute post-streptococcal glomerulonephritis (disorder) 6

acute post-streptococcal glomerulonephritis 43 post-streptococcal glomerulonephritis 6

Diseases related to acute poststreptococcal glomerulonephritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 238)

id	Related Disease	Score	Top Affiliating Genes
1	impetigo	30.6	CD79A, SKA1, SKA2, EDNRB, PRRT1
2	hemolytic-uremic syndrome	30.2	CD79A, ALB, HP, C5
3	glomerulonephritis	26.8	SFMBT1, SERPINF2, CFP, CD79A, CCL2, ALB
4	nephrotic syndrome	25.9	SERPINF2, CFP, CD79A, CCL2, ALB, HP
5	hypertension	25.9	SERPINF2, CD79A, CCL2, ALB, HP, PLG
6	membranoproliferative glomerulonephritis type 2	13.5	CFP, CD79A
7	herpes gestationis	13.5	CFP, CD79A
8	sneddon syndrome	13.4	CD79A, PF4
9	immunoglobulin alpha deficiency	13.3	CD79A, HP
10	berger disease	13.3	CD79A, ALB
11	mitral valve stenosis	13.2	PF4, NPPA
12	hemorrhagic disease	13.2	SERPINF2, PF4
13	intermediate coronary syndrome	13.2	PLG, PF4
14	calciphylaxis	13.1	CD79A, ALB
15	protein-losing enteropathy	13.1	CD79A, ALB
16	chronic pyelonephritis	13.1	CD79A, ALB
17	myxedema	13.1	CD79A, NPPA
18	heparin-induced thrombocytopenia	13.1	CD79A, ALB, PF4
19	scurvy	13.0	ALB, HP
20	thromboembolism	13.0	SERPINF2, PLG, PF4
21	rapidly progressive glomerulonephritis	13.0	CCL2, C5
22	meningoencephalitis	13.0	CD79A, ALB, C5
23	hyperthyroxinemia	12.9	CD79A, ALB
24	short limb dwarf edema iris coloboma	12.9	ALB, NPPA
25	extrinsic allergic alveolitis	12.9	CD79A, ALB, HP
26	protein-energy malnutrition	12.9	CD79A, ALB, HP
27	pure red-cell aplasia	12.9	CD79A, ALB, HP
28	protein c deficiency	12.8	SERPINF2, CFP, PLG, PF4
29	peripheral vascular disease	12.8	ALB, PF4
30	chronic rapidly progressive glomerulonephritis	12.8	CD79A, ALB, NPPA
31	factor v leiden thrombophilia	12.8	SERPINF2, CFP, PLG, PF4
32	paraneoplastic syndromes	12.7	CD79A, ALB, NPPA
33	alopecia areata	12.7	CD79A, CCL2, C5
34	primary sclerosing cholangitis	12.7	CD79A, ALB, HP
35	strongyloidiasis	12.7	CD79A, ALB
36	aspergillosis	12.7	CD79A, ALB, PLG
37	optic nerve disease	12.7	EDN1, EDNRB
38	lipoid nephrosis	12.7	CD79A, CCL2, ALB
39	sclerosing cholangitis	12.7	CD79A, ALB, HP
40	venous tributary occlusion of retina	12.7	SERPINF2, PF4, EDN1
41	lymphatic system disease	12.6	CD79A, ALB
42	renal hypertension	12.6	ALB, EDN1
43	megakaryoblastic leukemia	12.6	PF4, EDN1, EDNRB
44	thrombophilia	12.6	SERPINF2, HP, PLG, PF4
45	acute kidney tubular necrosis	12.6	ALB, HP, NPPA
46	urticaria	12.6	SERPINF2, CD79A, CCL2, PF4
47	appendicitis	12.6	CD79A, CCL2, ALB
48	pyelonephritis	12.6	CD79A, CCL2, ALB
49	leptospirosis	12.6	CD79A, CCL2, ALB
50	gout	12.5	CFP, CD79A, ALB, HP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to acute poststreptococcal glomerulonephritis:

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MGI Mouse Phenotypes related to acute poststreptococcal glomerulonephritis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	7.3	EDNRB, EDN1, PLG, HP, ALB, CD79A
2	homeostasis/metabolism phenotype	MP:0005376	5.3	SERPINF2, C5, NPPA, EDNRB, EDN1, PF4

Articles related to acute poststreptococcal glomerulonephritis:

id	Title	Authors	Year	Affiliating Genes
1	Elevated urinary plasmin activity resistant to alpha2-antiplasmin in acute poststreptococcal glomerulonephritis. (18223261)	Oda T.... Miura S.	2008	PLG, SERPINF2
2	An adult with acute poststreptococcal glomerulonephritis complicated by hemolytic uremic syndrome and nephrotic syndrome. (16183409)	Izumi T.... Miura S.	2005	HP
3	Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis. (15206029)	Besbas N.... Bakkaloglu A.	2004	CCL2
4	Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. (12654066)	Nicolaidou P.... Zeis P.	2003	EDN1, NPPA
5	Anticardiolipin antibodies in acute poststreptococcal glomerulonephritis and streptococcal impetigo. (10461035)	Ardiles L.... Mezzano S.	1999	CD79A
6	Significance of albuminuria in the follow-up of acute poststreptococcal glomerulonephritis. (8050204)	Buzio C.... Bergamaschi E.	1994	ALB
7	Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. (1996575)	Matsell D.G.... Wyatt R.J.	1991	C5, CFP

Genes related to acute poststreptococcal glomerulonephritis according to GeneCards:

(show all 18)

id	Symbol	Description	Score	GeneCards Section Context
1	CFP	complement factor properdin	11.0	Publications
2	EDNRB	endothelin receptor type B	11.0
3	PF4	platelet factor 4	11.0
4	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
5	PRRT1	proline-rich transmembrane protein 1	11.0
6	SKA1	spindle and kinetochore associated complex subunit 1	11.0
7	SKA2	spindle and kinetochore associated complex subunit 2	11.0
8	SKA3	spindle and kinetochore associated complex subunit 3	11.0
9	LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	11.0	Disorders
10	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0	Publications
11	C5	complement component 5	11.0	Publications
12	SFMBT1	Scm-like with four mbt domains 1	11.0
13	PLG	plasminogen	11.0	Publications
14	HP	haptoglobin	11.0	Publications
15	NPPA	natriuretic peptide A	11.0	Publications
16	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
17	EDN1	endothelin 1	11.0	Publications
18	ALB	albumin	11.0	Publications

Pathways related to acute poststreptococcal glomerulonephritis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Complement and coagulation cascades20	9.1	SERPINF2, PLG, C5
2	Endothelin-1 Signaling Pathway36	8.6	CCL2, PF4, EDN1, EDNRB

Compounds related to acute poststreptococcal glomerulonephritis according to GeneDecks:

(show top 50)    (show all 88)

id	Compound	Score	Top Affiliating Genes
1	testosterone32 9 18 9	13.2	CD79A, SERPINF2
2	citrate32	9.9	HP, CD79A, PF4
3	haemaccel32	9.8	ALB, NPPA
4	sitaxsentan32	9.8	EDN1, EDNRB
5	pd 14506532	9.8	EDN1, EDNRB
6	pd 14289332	9.6	EDNRB, EDN1
7	bq 302032	9.6	EDN1, EDNRB
8	cellulose acetate32	9.6	ALB, CD79A, HP
9	ramipril32 9 9	11.6	CD79A, ALB, NPPA
10	bq61032	9.6	EDN1, EDNRB
11	spironolactone32 42 34 9 9	13.6	EDNRB, NPPA, ALB
12	bq 788 sodium salt42	9.6	EDN1, EDNRB
13	cysteine32	9.5	ALB, PF4, EDNRB, CD79A
14	ambrisentan32	9.5	EDNRB, EDN1
15	toki-shakuyaku-san32	9.5	EDN1, NPPA
16	sulfasalazine32 9 9	11.5	CD79A, HP, CCL2
17	tezosentan32	9.4	EDNRB, EDN1
18	bq12332	9.3	EDNRB, EDN1, NPPA
19	hirudin32	9.3	PF4, CCL2, SERPINF2
20	phosphoramidon32 9 9	11.3	EDNRB, EDN1, NPPA
21	thyroxine32 18	10.2	CD79A, ALB, SERPINF2, HP
22	anaphylatoxin32	9.1	HP, CFP, CCL2, C5, PF4
23	vitamin b1232	9.0	CD79A, CCL2, ALB, HP
24	6-ketoprostaglandin f1alpha32	9.0	NPPA, PF4, SERPINF2, EDN1
25	enalapril32 9 9	11.0	EDN1, NPPA, ALB
26	verapamil32 34 9 18 9	13.0	PF4, CCL2, EDN1, EDNRB
27	probucol32 9 9	11.0	EDN1, CCL2, HP
28	polyethylene glycol32	9.0	NPPA, PF4, HP, CD79A, ALB
29	valsartan32 42 9 9	11.9	EDN1, ALB, CCL2
30	indomethacin32 9 9	10.8	PF4, EDNRB, ALB, CD79A, EDN1
31	polysaccharide32	8.8	CD79A, HP, SERPINF2, CFP, CCL2, PF4
32	8-isoprostane32	8.8	EDN1, CCL2, HP
33	heparin32 9 18 9	11.8	SERPINF2, HP, CFP, PLG, ALB, CD79A
34	prostacyclin32	8.5	CCL2, PF4, EDN1, EDNRB, NPPA
35	kininogen32	8.5	HP, ALB, SERPINF2, PLG, PF4, NPPA
36	captopril32 42 9 9	11.4	PLG, CD79A, ALB, NPPA, EDN1
37	histamine32 18	9.4	ALB, EDN1, CD79A, CCL2, PF4
38	epinephrine32 9 18 9	11.3	SERPINF2, CD79A, HP, NPPA, PF4, EDN1
39	norepinephrine32 9 18 9	11.3	CCL2, CD79A, EDNRB, PF4, NPPA, EDN1
40	sodium dodecylsulfate32	8.2	CCL2, SERPINF2, NPPA, ALB, HP, CD79A
41	losartan32 34 9 9	11.2	ALB, NPPA, CCL2, EDNRB, EDN1
42	fibrinogen32	8.1	CCL2, SERPINF2, CD79A, PLG, PF4, HP
43	sodium32 18	9.1	HP, ALB, NPPA, EDNRB, PF4, EDN1
44	arachidonic acid32 9 18 9	10.9	PF4, EDN1, ALB, HP, PLG
45	cyclosporin a32 42	8.9	NPPA, CD79A, EDNRB, EDN1, HP
46	arginine32	7.9	PF4, EDN1, CCL2, CD79A, EDNRB, SERPINF2
47	pge232	7.8	EDNRB, CD79A, PF4, HP, CCL2, NPPA
48	oxygen32 18	8.7	CCL2, SERPINF2, NPPA, PLG, PF4, EDN1
49	creatinine32	7.5	PF4, HP, EDN1, NPPA, ALB, CCL2
50	vegf32	7.1	NPPA, CCL2, PF4, PLG, EDNRB, EDN1

Cellular components related to acute poststreptococcal glomerulonephritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	spindle microtubule	GO:005876	9.7	SKA1, SKA2, SKA3
2	condensed chromosome outer kinetochore	GO:000940	9.6	SKA3, SKA2, SKA1
3	platelet alpha granule lumen	GO:031093	8.7	SERPINF2, ALB, PLG, PF4
4	extracellular space	GO:005615	6.6	SERPINF2, C5, EDN1, PF4, PLG, HP
5	extracellular region	GO:005576	6.0	C5, NPPA, EDN1, PF4, PLG, HP

Biological processes related to acute poststreptococcal glomerulonephritis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of microtubule polymerization or depolymerization	GO:031110	9.9	SKA1, SKA2, SKA3
2	complement activation, alternative pathway	GO:006957	9.9	CFP, C5
3	chromosome segregation	GO:007059	9.8	SKA3, SKA2, SKA1
4	negative regulation of fibrinolysis	GO:051918	9.8	PLG, SERPINF2
5	negative regulation of cellular protein metabolic process	GO:032269	9.7	EDN1, EDNRB
6	mitotic anaphase	GO:000090	9.7	SKA2, SKA1
7	vein smooth muscle contraction	GO:014826	9.6	EDN1, EDNRB
8	macrophage chemotaxis	GO:048246	9.6	EDNRB, CCL2
9	vasoconstriction	GO:042310	9.3	EDNRB, EDN1
10	platelet degranulation	GO:002576	9.3	PF4, PLG, ALB, SERPINF2
11	maternal process involved in parturition	GO:060137	9.2	CCL2, EDN1
12	platelet activation	GO:030168	9.1	SERPINF2, ALB, PLG, PF4
13	cell surface receptor signaling pathway	GO:007166	8.7	C5, EDNRB, EDN1, CCL2

Molecular functions related to acute poststreptococcal glomerulonephritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	9.3	CCL2, PF4, C5