MCID: ACT040
MIFTS: 50

Acute Poststreptococcal Glomerulonephritis malady

Nephrological diseases category
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Summaries for Acute Poststreptococcal Glomerulonephritis

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MalaCards based summary: Acute Poststreptococcal Glomerulonephritis, also known as acute post-streptococcal glomerulonephritis, is related to glomerulonephritis and impetigo. An important gene associated with Acute Poststreptococcal Glomerulonephritis is CFP (complement factor properdin), and among its related pathways are Dissolution of Fibrin Clot and Prostaglandin Synthesis and Regulation. The compounds haemaccel and bq123 have been mentioned in the context of this disorder. Affiliated tissues include skin, monocytes and spleen, and related mouse phenotypes are tumorigenesis and immune system.

Aliases & Classifications for Acute Poststreptococcal Glomerulonephritis

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Acute Poststreptococcal Glomerulonephritis, Aliases & Descriptions:

Name: Acute Poststreptococcal Glomerulonephritis 8 10 44
Acute Post-Streptococcal Glomerulonephritis 8 62
 
Post-Streptococcal Glomerulonephritis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:14064
SNOMED-CT57 68544003
NCIt39 C35443

Related Diseases for Acute Poststreptococcal Glomerulonephritis

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Diseases related to Acute Poststreptococcal Glomerulonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.8EDNRB, CFP, CCL2, ALB, CD79A
2impetigo31.4SKA2
3membranoproliferative glomerulonephritis31.1CD79A, CFP
4nephritis30.9CFP, CCL2, ALB, CD79A
5autoimmune hemolytic anemia30.9HP, CD79A
6sickle cell disease30.5EDN1, PF4, HP
7rheumatoid arthritis30.4PF4, CCL2, HP, PLG, CD79A
8arthritis30.3ALB, PLG, HP, CCL2
9thrombocytopenia30.3CD79A, ALB, PLG, HP, PF4
10nephrotic syndrome30.2SERPINF2, HP, ALB, NPPA, CD79A
11hypertension29.6EDNRB, EDN1, CCL2, PLG, ALB, NPPA
12proteinuria29.1EDNRB, EDN1, CFP, PF4, CCL2, HP
13rheumatic fever10.6
14meningoencephalitis10.5CD79A
15pyelonephritis10.5CD79A
16intermediate coronary syndrome10.5PLG
17protein-losing enteropathy10.4ALB
18hypertensive encephalopathy10.4
19purpura10.4
20hemorrhagic disease10.4SERPINF2, PF4
21hyperthyroxinemia10.4ALB
22agammaglobulinemia10.4CFP, CD79A
23immunoglobulin alpha deficiency10.4HP, CD79A
24complement deficiency10.4C5, CFP
25corneal neovascularization10.4PLG, PF4
26septic shock10.3CFP, PF4, C4BPA
27conjunctivitis10.3CD79A, PLG
28protein c deficiency10.3CFP, PLG
29reactive arthritis10.3CD79A, HP
30mitral valve stenosis10.3PF4, NPPA
31cholangitis10.3ALB
32peripheral vascular disease10.3ALB, CD79A
33proliferative glomerulonephritis10.3CCL2, CD79A
34thrombocytosis10.3SERPINF2, PF4, HP
35thrombophilia10.3SERPINF2, PF4, PLG
36thromboembolism10.3SERPINF2, PF4, PLG
37cerebral hemorrhage10.3
38pharyngitis10.3
39bardet-biedl syndrome10.3
40hemolytic-uremic syndrome10.3
41wegener's granulomatosis10.3
42rapidly progressive glomerulonephritis10.3
43cerebritis10.3
44pneumonia10.3
45uremia10.3
46diffuse alveolar hemorrhage10.3
47low renin hypertension10.3EDN1
48meningitis10.3CD79A, ALB, CFP
49intestinal obstruction10.2EDNRB, ALB
50gastroenteritis10.2CD79A

Graphical network of the top 20 diseases related to Acute Poststreptococcal Glomerulonephritis:



Diseases related to acute poststreptococcal glomerulonephritis

Symptoms for Acute Poststreptococcal Glomerulonephritis

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Drugs & Therapeutics for Acute Poststreptococcal Glomerulonephritis

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Drug clinical trials:

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Genetic Tests for Acute Poststreptococcal Glomerulonephritis

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Anatomical Context for Acute Poststreptococcal Glomerulonephritis

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MalaCards organs/tissues related to Acute Poststreptococcal Glomerulonephritis:

32
Skin, Monocytes, Spleen, Brain

Animal Models for Acute Poststreptococcal Glomerulonephritis or affiliated genes

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MGI Mouse Phenotypes related to Acute Poststreptococcal Glomerulonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8EDNRB, CCL2, HP, PLG, ALB
2MP:00053878.6CFP, CCL2, HP, PLG, C5, CD79A
3MP:00053858.4EDNRB, EDN1, CFP, CCL2, HP, PLG
4MP:00053678.4EDNRB, EDN1, HP, PLG, ALB, NPPA
5MP:00028738.3EDN1, CFP, CCL2, ALB, C5, CD79A
6MP:00053766.9CD79A, EDNRB, EDN1, CFP, SERPINF2, PF4

Publications for Acute Poststreptococcal Glomerulonephritis

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Articles related to Acute Poststreptococcal Glomerulonephritis:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Diffuse alveolar hemorrhage as a presentation of acute poststreptococcal glomerulonephritis. (24927907)
2014
2
Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome. (22891230)
2012
3
Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis. (20640906)
2011
4
Elevated plasma levels of N-terminal pro-brain natriuretic peptide in children with acute poststreptococcal glomerulonephritis. (19346734)
2009
5
Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. (19095947)
2009
6
Acute poststreptococcal glomerulonephritis superimposed on IgA nephropathy. (18793531)
2008
7
Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis. (15206029)
2004
8
Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. (12654066)
2003
9
Acute poststreptococcal glomerulonephritis and acute rheumatic fever in the same patient: a case report and review of the literature. (12967898)
2003
10
Thrombocytopenia during the course of acute poststreptococcal glomerulonephritis. (12921303)
2003
11
Acute poststreptococcal glomerulonephritis in a child with Bardet-Biedl syndrome. (11793138)
2002
12
Another case of acute poststreptococcal glomerulonephritis with recurrence. (12162274)
2002
13
Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions. (11467793)
2001
14
Acute poststreptococcal glomerulonephritis following circumcision. (11149125)
2000
15
Evaluating the use of penicillin to control outbreaks of acute poststreptococcal glomerulonephritis. (10223684)
1999
16
Renal function during and after childhood acute poststreptococcal glomerulonephritis. (10603146)
1999
17
Acute poststreptococcal glomerulonephritis presenting with hemoptysis. (9686966)
1998
18
Searching for acute poststreptococcal glomerulonephritis-associated Streptococcus pyogenes in Australian aboriginal communities. (9331610)
1997
19
Myocardial dysfunction in a 23-month child with acute poststreptococcal glomerulonephritis. (7793601)
1995
20
Cytokine secretion by peripheral blood monocytes from patients with acute poststreptococcal glomerulonephritis. (7860208)
1994
21
Terminal complement complexes in acute poststreptococcal glomerulonephritis. (7696103)
1994
22
Cell-mediated immune response in acute poststreptococcal glomerulonephritis. (8022104)
1994
23
Plasma atrial natriuretic peptide and endothelin levels in acute poststreptococcal glomerulonephritis. (1482636)
1992
24
Failure to detect unique reactivity to streptococcal streptokinase in either the sera or renal biopsy specimens of patients with acute poststreptococcal glomerulonephritis. (1468160)
1992
25
Role of a streptococcal antigen in the pathogenesis of acute poststreptococcal glomerulonephritis. Characterization of the antigen and a proposed mechanism for the disease. (1578137)
1992
26
Medium- and long-term prognosis of patients with acute poststreptococcal glomerulonephritis. (1922602)
1991
27
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: occurrence in the same patient. (2253249)
1990
28
A case of acute poststreptococcal glomerulonephritis associated with cerebral hemorrhage. (3694896)
1987
29
Incidence of circulating immune complexes in patients with acute poststreptococcal glomerulonephritis and in patients with streptococcal impetigo. (3530567)
1986
30
Two cases of acute poststreptococcal glomerulonephritis superimposed on rheumatoid arthritis. (6242205)
1984
31
Acute poststreptococcal glomerulonephritis progressing to rapidly progressive glomerulonephritis. (6494975)
1984
32
Mendelian recessive ratios in acute poststreptococcal glomerulonephritis. (7128729)
1982
33
Characterization of the glomerular antibody in acute poststreptococcal glomerulonephritis. (6965830)
1980
34
Acute poststreptococcal glomerulonephritis in pregnancy: case report with an 18-year follow-up. (7405978)
1980
35
Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins. (314784)
1979
36
Second attack of acute poststreptococcal glomerulonephritis; report of two cases. (524922)
1979
37
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
38
Ultrasonic appearance of acute poststreptococcal glomerulonephritis. (416050)
1978
39
Evidence of an autologous immune complex pathogenic mechanism in acute poststreptococcal glomerulonephritis. (750695)
1978
40
Progression to uremia after remission of acute poststreptococcal glomerulonephritis. (787789)
1976
41
Prognosis of acute poststreptococcal glomerulonephritis in childhood: prospective study and review of the literature. (1008003)
1976
42
Immune deposits in the spleen of a patient with acute poststreptococcal glomerulonephritis (APSGN). (975639)
1976
43
Defective phagocyte adherence in acute poststreptococcal glomerulonephritis: clinical and laboratory observations. (978322)
1976
44
The fate of subepithelial deposits in acute poststreptococcal glomerulonephritis. (792564)
1976
45
Acute, poststreptococcal glomerulonephritis with failure to resolve. (4536431)
1973
46
Acute poststreptococcal glomerulonephritis. A retrospective study. (4752192)
1973
47
Editorial: Acute poststreptococcal glomerulonephritis. Mechanism and sequelae--attempts at a unifying concept. (4593114)
1972
48
A specific antigen and antibody in acute poststreptococcal glomerulonephritis. (4911994)
1969
49
Acute poststreptococcal glomerulonephritis. A case with minimal urinary abnormalities. (5807650)
1969
50
Acute poststreptococcal glomerulonephritis: immune deposit disease. (4159050)
1966

Variations for Acute Poststreptococcal Glomerulonephritis

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Expression for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Expression patterns in normal tissues for genes affiliated with Acute Poststreptococcal Glomerulonephritis

Search GEO for disease gene expression data for Acute Poststreptococcal Glomerulonephritis.

Pathways for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Pathways related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9PLG, SERPINF2
29.9EDN1, EDNRB
3
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.8C4BPA, C5, CFP
4
Show member pathways
9.5SERPINF2, PF4, PLG
5
Show member pathways
thioredoxin pathway37
9.4CCL2, PLG, ALB
6
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.4C4BPA, C5, PLG, SERPINF2
7
Show member pathways
9.4C5, PLG, CCL2, CFP
8
Show member pathways
9.1SERPINF2, PF4, PLG, ALB
9
Show member pathways
9.1SERPINF2, PF4, PLG, ALB
10
Show member pathways
8.5EDNRB, EDN1, PF4, CCL2, PLG, C5
11
Show member pathways
8.5EDNRB, EDN1, PF4, CCL2, PLG, C5

Compounds for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Compounds related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1haemaccel4410.1ALB, NPPA
2bq12344 2811.0EDNRB, EDN1, NPPA
3ramipril44 1110.9CD79A, NPPA, ALB
4phosphoramidon44 1110.8EDNRB, EDN1, NPPA
5cellulose acetate449.8CD79A, HP, ALB
6probucol44 1110.8CCL2, HP, EDN1
7spironolactone44 61 28 50 1113.8NPPA, ALB, EDNRB
8toki-shakuyaku-san449.8NPPA, EDN1
9sulfasalazine28 44 50 1112.8CD79A, CCL2, HP
10sitaxsentan44 2810.8EDNRB, EDN1
11valsartan44 61 28 1112.7EDN1, CCL2, ALB
12irbesartan44 28 50 1112.7ALB, EDN1, CCL2
13enalapril44 50 1111.7NPPA, ALB, EDN1
14vitamin b12449.6CD79A, CCL2, ALB, HP
158-isoprostane449.6EDN1, CCL2, HP
16pd 145065449.6EDNRB, EDN1
17thyroxine44 2410.5ALB, HP, CD79A, SERPINF2
186-ketoprostaglandin f1alpha449.5PF4, SERPINF2, NPPA, EDN1
19citrate449.4ALB, CD79A, HP, PF4
20hirudin449.4CCL2, PF4, SERPINF2
21verapamil44 28 50 24 1113.4PF4, CCL2, EDN1, EDNRB
22anaphylatoxin449.4HP, PF4, CFP, CCL2, C5
23captopril44 61 50 28 1113.3EDN1, ALB, PLG, NPPA, CD79A
24cyclosporin a44 28 6111.2EDNRB, NPPA, EDN1, CD79A, HP
25losartan44 50 28 1112.2NPPA, EDNRB, EDN1, CCL2, ALB
26polyethylene glycol449.2HP, PF4, NPPA, CD79A, ALB
27indomethacin44 28 61 1112.2CD79A, EDNRB, EDN1, PF4, ALB
28prostacyclin449.2NPPA, CCL2, EDN1, EDNRB, PF4
29polysaccharide449.1HP, CD79A, PF4, SERPINF2, CFP, CCL2
30sodium dodecylsulfate449.1ALB, CCL2, HP, NPPA, CD79A, SERPINF2
31histamine44 28 2411.0CD79A, PF4, EDN1, CCL2, ALB
32testosterone44 61 24 1112.0NPPA, ALB, SERPINF2, CCL2, HP, CD79A
33epinephrine44 24 1111.0EDN1, PF4, HP, NPPA, CD79A, SERPINF2
34norepinephrine44 24 1110.9CD79A, CCL2, NPPA, EDN1, PF4, EDNRB
35arachidonic acid44 28 24 1111.9HP, EDN1, PLG, PF4, ALB
36lactate448.9HP, PF4, CD79A, ALB, C4BPA
37kininogen448.9NPPA, PF4, ALB, PLG, SERPINF2, HP
38nitric oxide44 24 1110.8EDNRB, NPPA, HP, PLG, CCL2, EDN1
39cholesterol44 28 24 1111.8HP, ALB, SERPINF2, PF4, CCL2, C4BPA
40alanine448.8PF4, SERPINF2, HP, EDNRB, CD79A, ALB
41sodium44 249.8EDN1, PF4, HP, ALB, NPPA, EDNRB
42cysteine448.7CFP, PF4, HP, EDNRB, ALB, PLG
43pge2448.7EDNRB, EDN1, HP, PF4, CCL2, CD79A
44arginine448.7CCL2, NPPA, CD79A, SERPINF2, EDN1, EDNRB
45oxygen44 249.6PF4, EDN1, NPPA, PLG, CCL2, EDNRB
46heparin44 28 24 1111.5CFP, C4BPA, CD79A, SERPINF2, ALB, PLG
47creatinine448.5ALB, HP, CCL2, PF4, NPPA, EDN1
48fibrinogen448.4PF4, HP, C4BPA, CD79A, ALB, PLG
49vegf448.1NPPA, EDN1, SERPINF2, PF4, CCL2, HP
50calcium44 50 24 1110.7EDNRB, EDN1, SERPINF2, NPPA, C4BPA, CCL2

GO Terms for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Cellular components related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.0SERPINF2, HP, PLG, ALB, C4BPA
2platelet alpha granule lumenGO:0310939.0SERPINF2, PF4, PLG, ALB
3spindle microtubuleGO:0058768.5SKA2, SKA1, SKA3
4condensed chromosome outer kinetochoreGO:0009408.2SKA2, SKA1, SKA3
5extracellular spaceGO:0056157.3PF4, SERPINF2, CFP, EDN1, CCL2, HP
6extracellular regionGO:0055767.1C4BPA, EDN1, CFP, SERPINF2, PF4, CCL2

Biological processes related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00695710.3C5, CFP
2epithelial fluid transportGO:04204510.2EDNRB, EDN1
3negative regulation of fibrinolysisGO:05191810.2SERPINF2, PLG
4negative regulation of cellular protein metabolic processGO:03226910.2EDNRB, EDN1
5vein smooth muscle contractionGO:01482610.2EDNRB, EDN1
6macrophage chemotaxisGO:04824610.1EDNRB, CCL2
7positive regulation of urine volumeGO:03581010.1EDN1, EDNRB
8regulation of complement activationGO:03044910.1CFP, C5, C4BPA
9positive regulation of renal sodium excretionGO:03581510.1EDNRB, EDN1
10fibrinolysisGO:04273010.1PLG, SERPINF2
11vasoconstrictionGO:04231010.0EDN1, EDNRB
12maternal process involved in parturitionGO:06013710.0CCL2, EDN1
13regulation of pHGO:00688510.0EDNRB, EDN1
14response to organic substanceGO:0100339.8ALB, SERPINF2
15regulation of sensory perception of painGO:0519309.8EDN1, EDNRB
16cell surface receptor signaling pathwayGO:0071669.6C5, CCL2, EDN1, EDNRB
17response to amino acidGO:0432009.5CCL2, EDN1
18response to hypoxiaGO:0016669.4EDN1, CCL2, NPPA
19platelet degranulationGO:0025769.4ALB, PLG, PF4, SERPINF2
20platelet activationGO:0301689.4SERPINF2, PF4, PLG, ALB
21blood coagulationGO:0075969.1ALB, PLG, PF4, SERPINF2
22regulation of microtubule polymerization or depolymerizationGO:0311108.9SKA2, SKA1, SKA3
23chromosome segregationGO:0070598.8SKA2, SKA1, SKA3

Molecular functions related to Acute Poststreptococcal Glomerulonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antioxidant activityGO:0162099.8ALB, HP
2chemokine activityGO:0080099.1PF4, CCL2, C5
3protein bindingGO:0055155.5C4BPA, EDNRB, EDN1, SFMBT1, SERPINF2, HP

Products for genes affiliated with Acute Poststreptococcal Glomerulonephritis

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Sources for Acute Poststreptococcal Glomerulonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
51PubMed
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58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet