APL
MCID: ACT119
MIFTS: 66

Acute Promyelocytic Leukemia (APL) malady

Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Acute Promyelocytic Leukemia

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44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Acute promyelocytic leukemia is an aggressiveĀ type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. it is usually marked by a translocation of chromosomes 15 and 17. acute promyelocytic leukemia usually occurs in middle-aged adults. symptoms may include both bleeding and forming blood clots. last updated: 6/23/2011

MalaCards: Acute Promyelocytic Leukemia, also known as leukemia, acute promyelocytic, is related to leukemia and acute myeloid leukemia. An important gene associated with Acute Promyelocytic Leukemia is RARA (retinoic acid receptor, alpha), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and Adipogenesis. The drugs cyclophosphamide and etoposide and the compounds alpha-retinoic acid and ttab have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are reproductive system and tumorigenesis.

Wikipedia:66 Acute promyelocytic leukemia (APML, APL) is a subtype of acute myelogenous leukemia (AML), a cancer of... more...

Description from OMIM:48 612376

Aliases & Classifications for Acute Promyelocytic Leukemia

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44NIH Rare Diseases, 23GTR, 22Genetics Home Reference, 48OMIM, 46Novoseek, 50Orphanet, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
acute promyelocytic leukemia:
Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

acute promyelocytic leukemia 44 23 22 50 63
leukemia, acute promyelocytic 22 48
aml m3 22 63
acute myeloid leukemia with t(15;17)(q22;q12);(pml/raralpha) and variants 50
acute myeloblastic leukemia type 3 50
leukemia promyelocytic acute 46
myeloid leukemia, acute, m3 22
leukemia, myelocytic, acute 63
m3 anll 22
apl 22


External Ids:

MESH via Orphanet37 D015473
ICD10 via Orphanet27 C92.4
SNOMED-CT via Orphanet60 28950004
UMLS via Orphanet64 C0023487
OMIM48 612376
ICD1026 C92.4

Related Diseases for Acute Promyelocytic Leukemia

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18GeneCards, 19GeneDecks
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Diseases related to Acute Promyelocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.3FES, PML, NUMA1, CYP26A1, ZBTB16, FLT3
2acute myeloid leukemia31.3NPM1, FLT3
3myeloid leukemia31.3FES, FLT3, STAT5B, RARA, NPM1, CD33
4myelodysplastic syndromes30.9FLT3, RARA, NPM1, CD33
5acute leukemia30.6ZBTB16, PML, FLT3, STAT5B, RARA, NPM1
6chronic myeloid leukemia30.6PML, FES, FLT3, STAT5B, RARA, CD33
7myeloid sarcoma30.5CD33
8non-hodgkin lymphoma30.4ZBTB16, PML, FLT3, NPM1
9myelofibrosis30.3STAT5B, FLT3
10breast cancer30.2CYP26A1, NUMA1, PML, FLT3, PRKAR1A, STAT5B
11disseminated intravascular coagulation10.7
12pseudotumor cerebri10.6
13bone marrow necrosis10.6
14multiple sclerosis10.5
15endotheliitis10.5
16hematopoietic stem cell transplantation10.5
17acute myeloblastic leukemia type 310.5
18hypercalcemia10.4
19hepatitis10.4
20leukostasis10.3
21hemophagocytic lymphohistiocytosis10.3
22aplastic anemia10.3
23aspergillosis10.3
24dermatitis10.3
25meningitis10.3
26myocardial infarction10.3
27sarcoma10.3
28ring chromosome 610.3
29leukemia, acute promyelocytic, npm/rara type10.3
30leukemia, acute promyelocytic, numa/rara type10.3
31leukemia, acute promyelocytic, pl2f/rara type10.3
32leukemia, acute promyelocytic, pml/rara type10.3
33leukemia, acute promyelocytic, stat5b/rara type10.3
34polyploidy10.3
35focal segmental glomerulosclerosis10.2
36natural killer cell leukemia10.2
37splenic infarction10.2
38hyperhomocysteinemia10.2
39appendicitis10.2
40paralytic ileus10.2
41hepatitis b10.2
42placental abruption10.2
43noma10.2
44herpes zoster10.2
45septic arthritis10.2
46hepatic vein thrombosis10.2
47leukemoid reaction10.2
48granulomatous dermatitis10.2
49pulmonary edema10.2
50cerebritis10.2

Graphical network of the top 20 diseases related to Acute Promyelocytic Leukemia:



Diseases related to acute promyelocytic leukemia

Symptoms for Acute Promyelocytic Leukemia

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48OMIM
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Clinical features from OMIM:

612376

Drugs & Therapeutics for Acute Promyelocytic Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Acute Promyelocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Promyelocytic Leukemia

Search NIH Clinical Center for Acute Promyelocytic Leukemia

Search CenterWatch for Acute Promyelocytic Leukemia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Acute Promyelocytic Leukemia

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23GTR
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Genetic tests related to Acute Promyelocytic Leukemia:

id Genetic test Affiliating Genes
1 Acute Promyelocytic Leukemia23

Anatomical Context for Acute Promyelocytic Leukemia

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34MalaCards
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MalaCards organs/tissues related to Acute Promyelocytic Leukemia:

34
Myeloid, Bone, Bone marrow, Monocytes, Liver, Endothelial, Thyroid, Colon, Kidney, Adipocyte, Breast, Heart, T cells

Animal Models for Acute Promyelocytic Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Acute Promyelocytic Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.9CYP26A1, FES, PRKAR1A, STAT5B, RARA, ZBTB16
2MP:00020069.9NPM1, ZBTB16, PML, FES, FLT3, PRKAR1A
3MP:00028739.7CYP26A1, PML, FES, PRKAR1A, STAT5B, CRABP1
4MP:00053849.7ZBTB16, CYP26A1, NUMA1, PML, FLT3, PRKAR1A
5MP:00053979.6ZBTB16, PML, FES, FLT3, PRKAR1A, STAT5B
6MP:00053879.5ZBTB16, PML, FES, FLT3, PRKAR1A, STAT5B
7MP:00107689.2CYP26A1, NUMA1, PML, FES, FLT3, PRKAR1A

Publications for Acute Promyelocytic Leukemia

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53PubMed
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Articles related to Acute Promyelocytic Leukemia:

(show top 50)    (show all 998)
idTitleAuthorsYear
1
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
2
Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97. (23837667)
2013
3
Hepatotoxicity from arsenic trioxide for pediatric acute promyelocytic leukemia. (23412590)
2013
4
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. (23518351)
2013
5
Rare occurrence of the JAK1 mutation in acute promyelocytic leukemia patients. (23860541)
2013
6
A unique PML-RARI+ rearrangement involving chromosomes 11, 15, and 17 in a patient with acute promyelocytic leukemia. (23660071)
2013
7
Single-Agent Liposomal All-Trans-Retinoic Acid as Initial Therapy for Acute Promyelocytic Leukemia: 13-Year Follow-Up Data. (24128595)
2013
8
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. (23841729)
2013
9
ZBTB16-RARI+ variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature. (23071480)
2012
10
Long term curative effects of sequential therapy with all-trans retinoic acid, arsenious oxide and chemotherapy on patients with acute promyelocytic leukemia. (23168069)
2012
11
FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: a report from the Children's Oncology Group. (22378655)
2012
12
High incidence of acute promyelocytic leukemia specifically induced by N-nitroso-N-methylurea (NMU) in Sprague-Dawley rats. (21964634)
2012
13
Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. (22272800)
2012
14
AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance. (21385856)
2011
15
A novel PML-ADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia. (21529941)
2011
16
Increased incidence of central nervous system hemorrhages in patients with secondary acute promyelocytic leukemia after treatment of multiple sclerosis with mitoxantrone? (21632839)
2011
17
Acute Budd-Chiari syndrome in pediatric acute promyelocytic leukemia. (21649539)
2011
18
Treatment of therapy related acute promyelocytic leukemia with the combination of all trans retinoic acid and arsenic trioxide without chemotherapy: a series of three patients. (20350274)
2010
19
Acute promyelocytic leukemia occurring in a previously healthy bone marrow donor. (20620606)
2010
20
External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature. (20186102)
2010
21
A case of ischemic stroke in acute promyelocytic leukemia at initial presentation. Relevance of all-trans retinoic acid treatment. (20041837)
2010
22
Isolated bowel relapse in acute promyelocytic leukemia: an unusual site of extramedullary recurrence. (20713873)
2010
23
Autologous stem cell transplantation for patients with acute promyelocytic leukemia in second molecular remission. (20944181)
2010
24
FLT3 internal tandem duplication in patients with acute promyelocytic leukemia]. (17939400)
2007
25
CD2+ tetraploid acute promyelocytic leukemia variant with double (15;17) translocations. (15717685)
2005
26
Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression. (14645547)
2003
27
New highly sensitive fluorescence in situ hybridization method to detect PML/RARA fusion in acute promyelocytic leukemia. (12935927)
2003
28
The impact of arsenic trioxide or all-trans retinoic acid treatment on coagulopathy in acute promyelocytic leukemia]. (16206674)
2001
29
Effects of all-trans-retinoic acid and arsenic trioxide on the hemostatic disturbance associated with acute promyelocytic leukemia. (11369412)
2001
30
Pseudotumor cerebri induced by all-trans-retinoic acid in a child treated for acute promyelocytic leukemia. (10742073)
2000
31
Annexin II and bleeding in acute promyelocytic leukemia. (10099141)
1999
32
Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-trans retinoic acid and granulocyte colony-stimulating factor. (10381496)
1999
33
Terminal deletion of the long arm of chromosome 9 in acute promyelocytic leukemia with a cryptic PML/RAR alpha rearrangement. (10484977)
1999
34
The role of von Willebrand factor in the hemostatic defect of acute promyelocytic leukemia. (9922039)
1998
35
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. (9122233)
1997
36
All-trans retinoic acid-induced myelomonocytoid differentiation in acute promyelocytic leukemia]. (9194390)
1997
37
Variant and masked translocations in acute promyelocytic leukemia. (8819070)
1996
38
The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. (8562957)
1996
39
PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia. (8952164)
1996
40
Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in situ hybridization pattern with PML and RARA probes. (8956873)
1996
41
Loss of blast cell procoagulant activity and improvement of hemostatic variables in patients with acute promyelocytic leukemia administered all-trans-retinoic acid. (7620161)
1995
42
Retinoic acid and acute promyelocytic leukemia: a model of targetting treatment for human cancer. (7697468)
1994
43
The t(15;17) translocation in acute promyelocytic leukemia. (7934155)
1994
44
Retinoic acid receptors: involvement in acute promyelocytic leukemia. (7920173)
1994
45
Interstitial insertion of retinoic acid receptor-alpha gene in acute promyelocytic leukemia with normal chromosomes 15 and 17. (8180390)
1994
46
A non-classical translocation involving 17q12 (retinoic acid receptor alpha) in acute promyelocytic leukemia (APML) with atypical features. (8057672)
1994
47
Hypercalcemia associated with all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. (8501972)
1993
48
Molecular heterogeneity of the PML gene rearrangement in acute promyelocytic leukemia: prevalence and clinical significance. (8387477)
1993
49
Retinoic acid receptor alpha in acute promyelocytic leukemia. (8391236)
1993
50
Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia. (7680887)
1993

Variations for Acute Promyelocytic Leukemia

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Expression for genes affiliated with Acute Promyelocytic Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Promyelocytic Leukemia

Search GEO for disease gene expression data for Acute Promyelocytic Leukemia.

Pathways for genes affiliated with Acute Promyelocytic Leukemia

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51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 56Reactome, 31KEGG, 61Thomson Reuters
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Pathways related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3RARA, CYP26A1
210.2RARA, STAT5B, CYP26A1
310.2RARA, STAT5B, FES
410.2FES, FLT3, NPM1
5
Show member pathways
10.1RARA, CRABP1, CYP26A1
610.1ZBTB16, PML, FLT3, RARA
7
Show member pathways
Signal transduction PTEN pathway61
10.1RARA, STAT5B, FLT3, PML, ZBTB16
810.1ZBTB16, PML, FLT3, STAT5B, RARA

Compounds for genes affiliated with Acute Promyelocytic Leukemia

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB
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Compounds related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1alpha-retinoic acid4610.6RARA, PML
2ttab4610.6RARA, CYP26A1
3am 5804610.5CYP26A1, RARA
4ch 554610.5CRABP1, RARA
5arsenic trioxide52 1211.5RARA, PML
6tretinoin52 1211.5RARA, CRABP1, PML
7am804610.5RARA, CRABP1
8acitretin46 1211.5CYP26A1, CRABP1, RARA
9isotretinoin46 1211.5CYP26A1, CRABP1, RARA
10arsenite46 2511.4PML, FLT3, STAT5B, RARA
11imatinib46 52 1212.4FLT3, FIP1L1, STAT5B, RARA
12retinaldehyde4610.4RARA, CYP26A1
13gemtuzumab ozogamicin52 46 1212.3CD33, FLT3
14nitroblue tetrazolium4610.3RARA, CD33
15zinc46 2511.2ZBTB16, PML, STAT5B, RARA, NPM1
16retinoid4610.2ZBTB16, CYP26A1, PML, CRABP1, RARA, UBA7
17vitamin a46 25 1212.1RARA, CRABP1, CYP26A1
18threonine4610.1NUMA1, FES, FLT3, STAT5B, NPM1
19tyrosine4610.0ZBTB16, FES, FLT3, FIP1L1, STAT5B, RARA
20cysteine469.9NPM1, UBA7, RARA, PRKAR1A, PML
21calcium46 52 25 1212.8CLEC11A, PRKAR1A, ANXA8L2, ANXA8, CRABP1, RARA
22cycloheximide469.8TNFAIP2, STAT5B, RARA, NPM1
23retinoic acid46 2510.4NPM1, ZBTB16, CYP26A1, NUMA1, PML, TNFAIP2

GO Terms for genes affiliated with Acute Promyelocytic Leukemia

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17Gene Ontology
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Cellular components related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.1NPM1, RARA, STAT5B, PML, NUMA1
2cytosolGO:0058299.2NPM1, ZBTB16, NUMA1, PML, FES, PRKAR1A

Biological processes related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid receptor signaling pathwayGO:04838410.1CYP26A1, PML, RARA
2myeloid cell differentiationGO:03009910.0PML, ZBTB16
3signal transductionGO:00716510.0CD33, NPM1, RARA, CRABP1, PRKAR1A
4negative regulation of cell proliferationGO:0082859.9CD33, NPM1, RARA, FLT3, PML, ZBTB16

Molecular functions related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent phospholipid bindingGO:00554410.2ANXA8, ANXA8L2
2retinoic acid bindingGO:00197210.1RARA, CRABP1, CYP26A1
3protein bindingGO:0055159.1ZBTB16, NUMA1, PML, FES, FLT3, PRKAR1A

Products for genes affiliated with Acute Promyelocytic Leukemia

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Sources for Acute Promyelocytic Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet