Acute Promyelocytic Leukemia malady

Genetics Home Reference: Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.¹⁷

MalaCards: Acute Promyelocytic Leukemia, also known as leukemia, acute promyelocytic, is related to acute lymphoblastic leukemia and chronic lymphocytic leukemia. An important gene associated with Acute Promyelocytic Leukemia is PML (promyelocytic leukemia), and among its related pathways are Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 and Acute myeloid leukemia. The drugs idarubicin and isotretinoin and the compounds glucose and ornithine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and small intestine, and related mouse phenotypes are hematopoietic system and respiratory system.

NIH Rare Diseases: Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.³⁰

Wikipedia: Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia (AML), a cancer of the blood and...⁴⁴ more...

OMIM: 612376

acute promyelocytic leukemia 30 17 43 leukemia, acute promyelocytic 17 33 aml m3 17 43 leukemia promyelocytic acute 32 myeloid leukemia, acute, m3 17

leukemia, myelocytic, acute 43 myeloid leukemia 43 leukemia 43 m3 anll 17 apl 17

Diseases related to acute promyelocytic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1033)

id	Related Disease	Score	Top Affiliating Genes
1	acute lymphoblastic leukemia	40.2	RB1, SERPINC1, BCL2, BCL2L1, BCL6, LEPR
2	chronic lymphocytic leukemia	39.5	BIRC3, BIRC5, BCL2, BCL2L1, BCL6, BAX
3	hairy cell leukemia	36.9	BCL6, ITGAX, ITGB2, FLT3, IL1A, IL3
4	juvenile myelomonocytic leukemia	35.3	RARA, CDKN3, IRF1, FLT3, ANXA2, CBL
5	chronic myelomonocytic leukemia	34.8	MPO, FLT3, CSF1, CSF1R, CSF2, CSF3
6	down syndrome	34.7	RB1, MYC, RARA, BCL6, CD7, MLL
7	human t-cell leukemia virus type 1	34.4	RB1, MYC, BIRC5, BCL2, BCL2L1, CDKN1A
8	leukemia	34.2	PIK3CB, PIK3CD, PIK3CA, PIK3CG, PINX1, NCAM1
9	acute megakaryoblastic leukemia	34.0	MPO, MLL, IL3, THPO, CSF2, RUNX1
10	acute lymphocytic leukemia	33.9	RB1, SERPINC1, MYC, BIRC5, BCL2, BAX
11	childhood leukemia	33.7	NCOR1, BCL2, BCL2L1, BAX, CDKN1A, CDKN2B
12	acute leukemia	33.7	PIK3CA, NCAM1, NCOR1, NCOR2, VWF, RB1
13	megakaryocytic leukemia	33.3	PIK3CD, NCAM1, VWF, BCL2, MPO, CDKN1A
14	megakaryoblastic leukemia	33.0	VWF, SELP, VDR, MPO, CDKN1A, MLL
15	chronic neutrophilic leukemia	32.6	BIRC3, XIAP, CD34, MLL, CSF2, CSF3
16	myeloproliferative disorder	32.3	VWF, SELP, VAV1, MPO, MLL, FLT3
17	acute t cell leukemia	32.3	PARP1, CD7, FAS, CASP3, CYCS, NOTCH1
18	myelodysplastic syndrome	32.3	VDR, RARA, BIRC5, LEPR, XIAP, MPO
19	b-cell lymphomas	32.2	RB1, MYC, BIRC3, BIRC5, PARP1, BCL2
20	plasma cell leukemia	32.1	NCAM1, CDK4, ITGB1, IL6, IFNA1, TP73
21	severe congenital neutropenia	32.1	IL3, ELANE, CSF2, CSF3, CSF3R
22	acute biphenotypic leukemia	32.1	MPO, MLL, F3, F2, NOTCH1
23	acute lymphoblastic leukemia, childhood	32.0	RARB, PARP1, BCL2L1, LEPR, BAX, CDKN2B
24	acute myelomonocytic leukemia	31.8	MPO, MLL, CSF1, CSF1R, RUNX1
25	lymphoblastic lymphoma	31.7	NCAM1, SERPINC1, MYC, BCL2, BCL6, CDKN1A
26	acute myeloid leukemia, adult	31.4	NCAM1, BCL2L1, CDKN2B, CD34, MLL, FLT3
27	wilms tumor	31.3	NCAM1, VWF, VDR, MYC, BIRC5, BCL2
28	mastocytosis	31.2	PIK3CD, PIK3CA, RARA, BCL2, BCL2L1, MPO
29	diphtheria	31.2	PARP1, BCL2, ITGAX, IL18, IL3, CCL3
30	immunodeficiency	31.2	PIK3CD, PARP1, CDKN3, ITGAL, ITGB2, IL10
31	leukemia, acute nonlymphocytic	31.1	CD33, CD34, CD7, MLL, IL3, ABCB1
32	granulocytopenia	31.1	ITGAM, IL3, TNF, CSF2, CSF3, CPQ
33	dna topoisomerase ii	31.1	MYC, BCL2L1, CDKN1A, MLL, ABCB1, ABCC1
34	myelomonocytic leukemia	30.9	RB1, MYC, RARA, BIRC5, KAT6A, MPO
35	hepatitis	30.8	RBP4, SELP, FAS, IFNA1, IFNA2, F2
36	lymphocytic leukemia	30.7	PIK3CD, PIK3CA, PIK3CG, NCAM1, RB1, SELP
37	graft versus host disease	30.5	ITGAL, IL10, IL18, IL3, FAS, CCL5
38	hypereosinophilic syndrome	30.4	IL3, IL5, IFNA1, IFNA2, F5, WT1
39	burkitt's lymphoma	30.4	MYC, BIRC3, BIRC5, PARP1, BCL2, BCL2L1
40	hypercalcemia	30.3	VDR, IL1A, IL1B, IL3, IL6, CCL4
41	disseminated intravascular coagulation	30.3	VWF, SERPINC1, SERPINE1, RARA, BCHE, MPO
42	large granular lymphocyte leukemia	30.2	PIK3CG, BCL2, BCL2L1, IL10, IL18, IL6
43	lymphoblastic leukemia	30.2	PIK3CA, PIK3CG, NCAM1, NCOA3, VWF, RB1
44	multiple sclerosis	29.9	CD14, IL1A, IL1B, IFNG, ICAM1, HLA-DRA
45	adult t-cell leukemia	29.8	NCAM1, MYC, BCL2, BCL2L1, BCL6, LCP2
46	hodgkin's lymphoma	29.8	PIK3CG, PCGF2, SELP, BIRC3, BCL2, BCL2L1
47	non-hodgkin lymphoma	29.8	NCOR2, VDR, MYC, BIRC3, BIRC5, BCL2
48	breast cancer	29.8	NCOA3, VDR, BCL2, IL10, IL1B, IL6
49	leukemia/lymphoma, t-cell	29.7	RB1, MYC, PARP1, BCL2, UGCG, XIAP
50	paroxysmal nocturnal hemoglobinuria	29.5	VWF, SELP, CD14, CD59, ANXA5, NRAS

Clinical features from OMIM: 612376

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 arsenic trioxide, cyclophosphamide, cytarabine, cytarabine liposome, daunorubicin, daunorubicin citrate liposome, daunorubicin hydrochloride, doxorubicin hydrochloride, etoposide, etoposide phosphate, idarubicin, idarubicin hydrochloride, irinotecan, irinotecan hydrochloride, isotretinoin, methotrexate, methotrexate sodium, mitoxantrone, mitoxantrone hydrochloride, pipobroman, tretinoin, tretinoin pwdr [va product], vincristine, vincristine sulfate

MalaCards organs/tissues related to acute promyelocytic leukemia:

²²

MGI Mouse Phenotypes related to acute promyelocytic leukemia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.7	PINX1, PCGF2, RBP1, BIRC3, BCL2, BCL2L1
2	respiratory system phenotype	MP:0005388	11.0	SELP, BCL6, LEPR, LCP2, CD14, MEIS1
3	endocrine/exocrine gland phenotype	MP:0005379	10.5	RARG, ZBTB16, CDKN2B, CDKN1B, CCNA1, IFNG
4	craniofacial phenotype	MP:0005382	10.5	NCOA3, NCOR2, PCGF2, RARG, BCOR, KAT6A
5	no phenotypic analysis	MP:0003012	10.2	PIK3CD, RB1, MYC, PARP1, LEPR, UGCG
6	liver/biliary system phenotype	MP:0005370	10.1	NCOA3, NCOR1, NCOR2, RBP1, SERPINC1, BCL6
7	other phenotype	MP:0005395	10.0	RARG, RARA, RARB, LEPR, ITGB1, TP73
8	normal phenotype	MP:0002873	9.8	RBP4, VAV1, MYC, BMP2, RARG, RARA
9	limbs/digits/tail phenotype	MP:0005371	9.6	PCGF2, RB1, VDR, BMP2, RARA, RARB
10	renal/urinary system phenotype	MP:0005367	9.5	NCOA3, SELP, RARA, RARB, BCL2, LEPR
11	immune system phenotype	MP:0005387	9.4	PIK3CD, NCOA3, NCOR1, VWF, PCGF2, RBP1
12	pigmentation phenotype	MP:0001186	9.4	RB1, RBP1, SERPINC1, MYC, BCL2, CDKN1B
13	embryogenesis phenotype	MP:0005380	9.2	PIK3CB, PIK3CA, PINX1, NCOA3, NCOR1, PCGF2
14	hearing/vestibular/ear phenotype	MP:0005377	9.1	NCOA3, RB1, RBP1, VDR, MYC, BMP2
15	skeleton phenotype	MP:0005390	8.6	PIK3CD, PIK3CG, RB1, VDR, MYC, BMP2
16	integument phenotype	MP:0010771	8.5	PIK3CG, PINX1, NCOA3, NCOR1, RB1, SELP
17	digestive/alimentary phenotype	MP:0005381	8.2	NCOA3, NCOR2, VWF, PCGF2, RB1, VDR
18	adipose tissue phenotype	MP:0005375	8.1	PIK3CA, NCOA3, NCOR1, NCOR2, RB1, SERPINE1
19	growth/size phenotype	MP:0005378	7.4	PIK3CB, PIK3CA, PIK3CG, PINX1, NCOA3, NCOR1
20	nervous system phenotype	MP:0003631	7.3	NCOR1, VWF, PCGF2, RB1, RBP1, SELP
21	reproductive system phenotype	MP:0005389	7.2	PIK3CA, NCOA3, RBP4, RBP1, VDR, VAV1
22	vision/eye phenotype	MP:0005391	6.7	PIK3CA, NCAM1, PCGF2, RB1, RBP4, RBP1
23	mortality/aging	MP:0010768	6.5	PIK3CB, PIK3CA, PINX1, NCAM1, NCOR1, NCOR2
24	tumorigenesis	MP:0002006	5.7	PIK3CB, PIK3CA, PINX1, NCOA3, RB1, SERPINE1
25	homeostasis/metabolism phenotype	MP:0005376	5.4	PIK3CB, PIK3CD, PIK3CA, PIK3CG, NCOA3, NCOR1
26	behavior/neurological phenotype	MP:0005386	5.3	PIK3CA, NCAM1, NCOA3, NCOR1, NCOR2, RB1
27	muscle phenotype	MP:0005369	5.0	PIK3CA, PIK3CG, NCOA3, NCOR1, RB1, RBP4
28	cellular phenotype	MP:0005384	4.7	PIK3CB, PIK3CD, PIK3CA, PIK3CG, PINX1, NCAM1
29	cardiovascular system phenotype	MP:0005385	3.7	PIK3CB, PIK3CD, PIK3CA, PIK3CG, PINX1, NCOR2

Articles related to acute promyelocytic leukemia:

(show top 50)    (show all 446)

id	Title	Authors	Year	Affiliating Genes
1	A novel PML-ADAMTS17-RARA gene rearrangement in a pat ient with pregnancy-related acute promyelocytic leukemia. (21529941)	Lim G.... Park T.S.	2011	PML
2	Identification of a myeloid committed progenitor as t he cancer-initiating cell in acute promyelocytic leukemia. (19797526)	Guibal F.C.... Tenen D.G.	2009	CEBPA
3	Acute promyelocytic leukemia with t(15;17): frequency of additional clonal chromosome abnormalities and FLT3 mutations. (19052993)	De Lourdes Chauffaille M.... Alberto F.L.	2008	FLT3
4	PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. (18636556)	Li L.... Yi J.	2008	RARA, PML
5	Expression level changes of inhibitor of differentiation 1 during ATRA-induced acute promyelocytic leukemia cells differentiation (19031736)	Zheng P.Z.... Chen Y.L.	2008	ID1
6	Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. (17560333)	Villa R.... Di Croce L.	2007	RARA, EZH2, EED
7	PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic t roxide) for acute promyelocytic leukemia. (17929112)	Ohnishi K.	2007	CRABP1
8	Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH. (16797070)	Han J.Y.... Kim J.S.	2007	RARA, PML
9	MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. (17260024)	Garzon R.... Croce C.M.	2007	NFIA
10	Adverse prognostic impact of CDKN2B hyper-methylation in acute promyelocytic leukemia. (16753865)	Chim C.S.... Kwong Y.L.	2006	CDKN2B
11	Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor. (16525492)	Chim C.S.... Kwong Y.L.	2006	WIF1
12	Deletion of MYC and presence of double minutes with MYC amplification in a morphologic acute promyelocytic leukemia-like case lacking RARA rearrangement: could early exclusion of double-minute chromosomes be a prognostic factor? (16631470)	Frater J.L.... Batanian J.R.	2006	MYC
13	Tyrosine phosphorylation modulates binding preference to cyclin- dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4. (16195327)	Kardinal C.... Welte K.	2006	CDK4, CDKN1B, CSF3
14	CD44 ligation induces apoptosis via caspase- and serine protease-dependent pathways in acute promyelocytic leukemia cells. (16208414)	Maquarre E.... Robert-Lezenes J.	2005	CD44
15	Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia. (14630830)	Gurrieri C.... Pandolfi P.P.	2004	PML
16	CD34 expression is associated with poor clinical outcome in patients with acute promyelocytic leukemia. (12827650)	Lee J.J.... Kim H.J.	2003	CD34
17	New highly sensitive fluorescence in situ hybridization method to detect PML/RARA fusion in acute promyelocytic leukemia. (12935927)	Brockman S.R.... Dewald G.W.	2003	RARA, PML
18	Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. (14959844)	Dong S.... Tweardy D.J.	2003	STAT3
19	Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. (11698395)	Kwon S.H.... Han J.W.	2002	CASP3
20	UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. (11891284)	Kitareewan S.... Dmitrovsky E.	2002	RARA, PML, UBA7
21	Effects of all-trans-retinoic acid and arsenic trioxide on the hemostatic disturbance associated with acute promyelocytic leukemia. (11369412)	Zhao W.... Wang Z.	2001	PLAT, F3
22	Acute promyelocytic leukemia with a PLZF-RARalpha fusion protein. (11172538)	Jansen J.H.... LAPwenberg B.	2001	RARA, CSF3
23	Acute promyelocytic leukemia with apparently normal karyotype: molecular findings and response to all-trans retinoic acid. (11699203)	Kohno A.... Saito H.	2001	RARA
24	Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARalpha and PML-RARalpha. (11342454)	Gianni' M.... Garattini E.	2001	RARA, RARRES2
25	Inhibition of ATRA-induced myeloid differentiation in acute promyelocytic leukemia by a new protein tyrosine phosphatase inhibitor, 3,4-dephostatin. (11144530)	Uesugi Y.... Aizawa Y.	2000	PTPN6, ACP1
26	Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. (10673743)	Cai X.... Chen G.Q.	2000	CASP3, CAT, NR6A1
27	In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications. (10498880)	He L.Z.... Pandolfi P.P.	1999	ZBTB16
28	Involvement of SHP-1, a phosphotyrosine phosphatase, during myeloid cell differentiation in acute promyelocytic leukemia cell lines. (10227457)	Uesugi Y.... Aizawa Y.	1999	PTPN6, CDKN3
29	PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. (10373566)	Sternsdorf T.... Ruthardt M.	1999	RARA, PML
30	Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia. (9989813)	Hummel J.L.... Kamel-Reid S.	1999	NCOR2, NCOR1, ZBTB16
31	Expression of interleukin-8 and its receptor in acute promyelocytic leukemia under all-trans retinoic acid treatment (11189515)	Zeng H.... Tao R.	1998	CXCR1
32	Prediction of growth sensitivity of acute promyelocytic leukemia cells to granulocyte colony-stimulating factor using 7AAD/PY during administration of all-trans retinoic acid. (9277051)	Toba K.... Aizawa Y.	1997	CSF3
33	Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling. (9234742)	Ruthardt M.... Pelicci P.G.	1997	RARA
34	Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). (9305596)	Kiyoi H.... Ohno R.	1997	FLT3
35	A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. (9122233)	Brown D.... Bishop J.M.	1997	RARA, PML
36	SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. (9256429)	Hong S.H.... Privalsky M.L.	1997	RARA, NCOR2, ZBTB16
37	RIG-E, a human homolog of the murine Ly-6 family, is induced by retinoic acid during the differentiation of acute promyelocytic leukemia cell. (8650192)	Mao M.... Chen Z.	1996	LY6E
38	In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML. (8643677)	Borden K.L.... Freemont P.S.	1996	RARA, PML
39	In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. (8704214)	Chen G.Q.... Chen Z.	1996	BCL2, PML
40	Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic a cid induces apoptosis independent of maturation and Bcl-2 expression. (7630193)	Bruel A.... Lanotte M.	1995	BCL2
41	Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RAR-alpha protein. (7620182)	Dyck J.A.... Miller W.H.	1995	RARA
42	Acute promyelocytic leukemia developed in a patient with congenital antithrombin III deficiency. (7718768)	Moriki T.... Ikeda Y.	1995	SERPINC1
43	Effect of the acute promyelocytic leukemia PML/RAR alpha protein on differentiation and survival of myeloid precursors. (8152308)	Fagioli M.... Pelicci P.G.	1994	RARA, PML
44	PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. (8302850)	Chen Z.... Chomienne C.	1994	RARA
45	Expression and ATRA-driven modulation of adhesion molecules in acute promyelocytic leukemia. (7967734)	Di Noto R.... Del Vecchio L.	1994	ITGB2, ITGAL, PTPN3
46	The immunophenotype of acute promyelocytic leukemia (APL): an ECOG study. (8035602)	Paietta E.... Wiernik P.H.	1994	CD7
47	Functional characteristics of in vivo induced neutrophils after differentiation therapy of acute promyelocytic leukemia with all-trans-retinoic acid. (8313324)	Glasser L.... Brothman A.R.	1994	MPO
48	Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells. (7511442)	Gianni M.... Garattini E.	1994	RARA, CSF3, CEBPB
49	Expression of granule protein mRNAs in acute promyelocytic leukemia. (8113151)	Hirata R.K.... Weil S.C.	1993	MPO, LTF, ELANE
50	Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation. (1319828)	Nervi C.... Jetten A.M.	1992	RARA, PML

Genes related to acute promyelocytic leukemia according to GeneCards:

(show top 50)    (show all 231)

id	Symbol	Description	Score	GeneCards Section Context
1	PML	promyelocytic leukemia	11.1	Publications, Summaries
2	RARA	retinoic acid receptor, alpha	11.1	Publications, Summaries
3	UBA7	ubiquitin-like modifier activating enzyme 7	11.1	Publications, Summaries
4	ZBTB16	zinc finger and BTB domain containing 16	11.1	Summaries, Publications
5	TNFAIP2	tumor necrosis factor, alpha-induced protein 2	11.1	Publications, Summaries
6	FES	feline sarcoma oncogene	11.1	Summaries
7	STAT5B	signal transducer and activator of transcription 5B	11.1	Publications, Summaries
8	MIR125B1	microRNA 125b-1	11.0	Publications
9	PRAM1	PML-RARA regulated adaptor molecule 1	11.0	Publications, Functions
10	RAB7B	RAB7B, member RAS oncogene family	11.0	Publications
11	CRABP1	cellular retinoic acid binding protein 1	11.0	Publications
12	ANXA8L2	annexin A8-like 2	11.0	Publications
13	CLEC11A	C-type lectin domain family 11, member A	11.0	Publications
14	ANXA8	annexin A8	11.0	Publications
15	LY6E	lymphocyte antigen 6 complex, locus E	11.0	Publications
16	HOXA7	homeobox A7	11.0	Publications
17	RIN1	Ras and Rab interactor 1	11.0	Publications
18	PPIC	peptidylprolyl isomerase C (cyclophilin C)	11.0	Publications
19	IFIT3	interferon-induced protein with tetratricopeptide repeats 3	11.0	Publications
20	LEPROT	leptin receptor overlapping transcript	11.0	Publications
21	TRIM38	tripartite motif containing 38	11.0	Publications
22	MIR146A	microRNA 146a	11.0	Publications
23	C19orf48	chromosome 19 open reading frame 48	11.0	Publications
24	CD33	CD33 molecule	11.0	Publications
25	CD7	CD7 molecule	11.0	Publications
26	DLX4	distal-less homeobox 4	11.0	Publications
27	PCGF2	polycomb group ring finger 2	11.0	Publications
28	RARRES2	retinoic acid receptor responder (tazarotene induced) 2	11.0	Publications
29	FUT4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	11.0	Publications
30	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	11.0	Publications
31	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	11.0	Publications
32	FLT3	fms-related tyrosine kinase 3	11.0	Publications
33	RARG	retinoic acid receptor, gamma	11.0	Publications
34	ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	11.0	Publications
35	ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	11.0	Publications
36	CRABP2	cellular retinoic acid binding protein 2	11.0	Publications
37	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	11.0	Publications
38	LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)	11.0	Publications
39	ISG15	ISG15 ubiquitin-like modifier	11.0	Publications
40	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
41	EIF5	eukaryotic translation initiation factor 5	11.0	Publications
42	PRAME	preferentially expressed antigen in melanoma	11.0	Publications
43	PRDX3	peroxiredoxin 3	11.0	Publications
44	NUMA1	nuclear mitotic apparatus protein 1	11.0	Publications
45	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
46	AHCY	adenosylhomocysteinase	11.0	Publications
47	CXCR1	chemokine (C-X-C motif) receptor 1	11.0	Publications
48	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
49	MFGE8	milk fat globule-EGF factor 8 protein	11.0	Publications
50	WIF1	WNT inhibitory factor 1	11.0	Publications

Pathways related to acute promyelocytic leukemia according to GeneDecks:

(show top 50)    (show all 349)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	11.0	PIK3CD, MAPK9
2	Acute myeloid leukemia20	10.8	PIK3CB, PIK3CD, PIK3CA, PIK3CG, MYC, RARA
3	EGFR Inhibitor Pathway, Pharmacodynamics34	10.8	HRAS, NRAS, KRAS, STAT2, STAT5B
4	RAR-Gamma-RXR-Alpha Degradation36	10.8	BMP2, RARG, IL3, MAPK10, MAPK9, CCL4
5	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	10.7	PIK3CB, PIK3CD, MAPK9, MAP2K1, CYCS
6	Small cell lung cancer20	10.3	PIK3CB, PIK3CD, PIK3CA, PIK3CG, RB1, MYC
7	Fc epsilon RI signaling pathway20	10.2	PIK3CB, PIK3CD, PIK3CA, PIK3CG, VAV1, LCP2
8	Hematopoietic cell lineage20	9.9	CD33, CD14, CD59, CD34, CD44, CD7
9	Development Prolactin receptor signaling10	9.9	PIK3CB, PIK3CD, PIK3CA, VAV1, MYC, BCL2
10	Development_Prolactin receptor signaling41	9.9	PIK3CB, PIK3CD, PIK3CA, VAV1, MYC, BCL2
11	Regulation of eIF4 and p70S6K36	9.8	BMP2, BAX, ITGAL, ITGAM, ITGAX, ITGB1
12	Development_EGFR signaling via small GTPases41	9.8	MYC, FOS, MAPK8, MAPK10, MAPK1, MAP2K1
13	Apoptosis20	9.7	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BIRC3, BCL2
14	Development EPO-induced Jak-STAT pathway10	9.7	MYC, BCL2, BCL2L1, XIAP, FES, MAPK1
15	Development_EPO-induced Jak-STAT pathway41	9.7	MYC, BCL2, BCL2L1, XIAP, FES, MAPK1
16	Development EGFR signaling via small GTPases10	9.6	PIK3CB, PIK3CD, PIK3CA, MYC, FOS, MAPK8
17	Immune response IFN gamma signaling pathway10	9.5	RAPGEF1, IFNG, PTK2B, SRC, STAT1
18	ErbB signaling pathway20	9.2	PIK3CB, PIK3CD, PIK3CA, PIK3CG, MYC, CDKN1A
19	Amoebiasis20	9.1	PIK3CB, PIK3CD, PIK3CA, RAB7B, CD14, ITGAM
20	Development Thrombopoietin-regulated cell processes10	9.1	PIK3CB, PIK3CD, PIK3CA, VAV1, MYC, RAPGEF1
21	Chronic myeloid leukemia20	9.1	PIK3CB, PIK3CD, PIK3CA, PIK3CG, RB1, MYC
22	Development_EPO-induced MAPK pathway41	8.8	PIK3CG, VAV1, RAPGEF1, FOS, MAPK8, MAPK10
23	Immune response_IFN gamma signaling pathway41	8.6	PIK3CB, PIK3CD, PIK3CA, MYC, RAPGEF1, CEBPB
24	MAPK Signaling36	8.4	MYC, BMP2, BCL2, CEBPB, ITGAL, ITGAM
25	Chemokine signaling pathway20	8.4	PIK3CB, PIK3CD, PIK3CA, PIK3CG, VAV1, IL8
26	Osteoclast differentiation20	8.2	PIK3CB, PIK3CD, PIK3CA, PIK3CG, LCP2, FOS
27	IL-6 Pathway36	8.1	BMP2, BAX, IL10, IL18, IL3, IL5
28	ERK Signaling36	8.0	MYC, BMP2, ITGAL, ITGAM, ITGAX, ITGB1
29	Toxoplasmosis20	8.0	PIK3CB, PIK3CD, PIK3CA, PIK3CG, BIRC3, BCL2
30	Immune response_Role of integrins in NK cells cytotoxicity41	8.0	VAV1, ITGAL, ITGAM, ITGB1, ITGB2, FOS
31	Immune response Role of integrins in NK cells cytotoxicity10	7.7	VAV1, ITGAL, ITGAM, ITGB1, ITGB2, FOS
32	Molecular Mechanisms of Cancer36	7.6	PIK3CG, RB1, MYC, BMP2, RARA, RARB
33	SOCS Pathway36	7.6	BMP2, BCL2, BAX, IL10, IL18, IL1A
34	MIF Mediated Glucocorticoid Regulation36	7.4	BMP2, BCL2, BAX, CD14, IL10, IL18
35	Tuberculosis20	7.2	VDR, BCL2, BAX, CEBPB, CD14, ITGAM
36	p38 Signaling36	7.2	BMP2, BCL2, BAX, CEBPA, FLT3, IL10
37	Malaria20	7.2	SELP, ITGAL, ITGB2, IL10, IL18, IL1B
38	Rheumatoid arthritis20	7.2	ITGAL, ITGB2, FOS, IL18, IL1A, IL1B
39	PAK Pathway36	7.0	BMP2, BCL2, BAX, IL10, IL18, IL1A
40	MIF Regulation of Innate Immune Cells36	7.0	BMP2, BCL2, BAX, CD14, FOS, IL10
41	PEDF Induced Signaling36	7.0	BMP2, BCL2, BCL2L1, BAX, FOS, IL10
42	Tec Kinases Signaling36	6.9	VAV1, BMP2, BCL2, LCP2, BAX, ITGAL
43	TGF-Beta Pathway36	6.6	BMP2, BCL2, BAX, FOS, IL10, IL18
44	MAPK Family Pathway36	6.6	BMP2, BCL2, BAX, IL10, IL18, IL1A
45	Rho Family GTPases36	6.5	BMP2, BCL2, BAX, ITGAL, ITGAM, ITGAX
46	Cytokine-cytokine receptor interaction20	6.4	BMP2, LEPR, FLT3, IL10, IL18, IL1A
47	STAT3 Pathway36	6.1	MYC, BMP2, BCL2, BAX, CDKN1A, IL10
48	Glucocorticoid Receptor Signaling36	6.0	NCOA3, NCOR1, NCOR2, BMP2, BCL2, BAX
49	JAK-STAT Pathway36	6.0	MYC, BMP2, BCL2, BAX, FOS, FLT3
50	Chagas disease (American trypanosomiasis)20	5.9	PIK3CB, PIK3CD, PIK3CA, PIK3CG, SERPINE1, FOS

Compounds related to acute promyelocytic leukemia according to GeneDecks:

(show top 50)    (show all 500)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.1	RARRES2, SAFB, XIAP, CDK4, IFNA2, PTHLH
2	ornithine32 18	11.8	RBP4, MYC, RARA, CDK4, ITGAM, FOS
3	leucine32	10.5	PIK3CA, RB1, RBP4, VAV1, MYC, RARS
4	budesonide32 42 9 9	13.5	PTGS1, LTF, CSF2
5	phosphatidylserine32 9 9	12.0	VWF, PARP1, BCL2, CD14, MFGE8, ANXA2
6	agar32	9.9	PIK3CA, RB1, RARA, RARB, BIRC5, XIAP
7	rituximab32 34 9 9	12.9	BIRC5, BCL2, BCL2L1, BCL6, XIAP, CD59
8	ceramide32	9.7	PIK3CA, RB1, BCL2L1, UGCG, XIAP, CDKN1B
9	pge232	9.7	BMP2, CD14, IRF1, IL1A, IL5, MAPK10
10	aprotinin32 9 9	11.7	VWF, SELP, SERPINC1, IL1A, MAP2K1, F5
11	hyaluronic acid32 18	10.6	MYC, CD44, ITGAL, ITGB2, MAPK10, F2
12	estradiol32 9 18 9	12.6	NCOA3, NCOR1, NCOR2, RB1, SERPINE1, RARB
13	calcium32 9 18 9	12.6	PIK3CD, VWF, RB1, RBP4, VAV1, BMP2
14	phosphotyrosine32	9.5	PIK3CB, PIK3CA, PIK3CG, VAV1, LCP2, SAFB
15	atp32	9.5	PIK3CB, PIK3CA, NCAM1, RB1, BIRC5, PARP1
16	polysaccharide32	9.4	NCAM1, NCOA3, SELP, SERPINC1, BMP2, FUT4
17	c2ceramide32	9.4	PIK3CG, PARP1, BCL2L1, UGCG, BAX, IL1B
18	calcitriol32 42 9 18 9	13.3	PIK3CB, NCOA3, RB1, VDR, MYC, BMP2
19	depsipeptide32	9.3	RB1, MYC, BCL2, BCL2L1, BAX, CDKN1A
20	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.1	MYC, PARP1, BCL2, BCL2L1, BAX, IL1A
21	ribonucleic acid32	9.1	RBP4, MYC, BMP2, RARA, RARB, LEPR
22	noxa32	9.0	BIRC5, BCL2, BCL2L1, BAX, XIAP, CDKN1A
23	flavopiridol32 9 9	10.9	PIK3CG, RB1, BIRC5, PARP1, BCL2, BCL2L1
24	atorvastatin32 34 9 18 9	12.8	VWF, SELP, BMP2, CD59, ITGAM, IL10
25	5-aza-2deoxycytidine32	8.7	RBP1, MYC, RARB, CDKN1A, CDKN2B, ITGAM
26	rottlerin32 42	9.7	PIK3CG, PARP1, XIAP, CDK1, ITGAM, IL8
27	ang ii32	8.7	PIK3CG, IL6ST, ANPEP, MAPK8, MAPK10, MAPK1
28	thymidylate32	8.6	RB1, VDR, BIRC5, BCL2, BCL2L1, BAX
29	oxygen32 18	9.4	RB1, RBP4, BMP2, BIRC3, BIRC5, PARP1
30	cysteine32	8.4	RBP4, SELP, VDR, RARA, RARB, RARRES2
31	ifn-alpha32	8.3	IRF1, IL10, IL18, IL6, IL6ST, FAS
32	cholesterol32 9 18 9	11.2	PIK3CB, PIK3CA, VWF, RB1, RBP4, SELP
33	parthenolide32	8.1	PIK3CG, BIRC3, BCL2L1, IL6, IL8, MAPK8
34	superoxide32 18	9.1	PIK3CA, RB1, VAV1, BIRC5, CLEC11A, LEPR
35	rosiglitazone32 9 18 9	11.0	PIK3CA, PIK3CG, NCOR1, RBP4, SERPINE1, RARB
36	poly(i-c)32	7.9	IRF1, IL18, IL1B, IL3, IL5, IL6
37	mip 1alpha32	7.8	IL10, IL1B, IL3, IL6, IL8, CCL4
38	paraffin32	7.7	NCAM1, VWF, RB1, RBP1, MYC, RARA
39	5fluorouracil32	7.6	PIK3CA, PIK3CG, RB1, VDR, BIRC3, BIRC5
40	polyinosinic-polycytidylic acid32	7.4	IRF1, IL10, IL18, IL1A, IL1B, IL5
41	matrigel32	6.9	PIK3CA, PIK3CG, NCAM1, VWF, RB1, SERPINE1
42	rantes32	6.8	SELP, CEBPB, CD14, CD44, ITGAL, ITGAM
43	lactate32	6.8	PIK3CA, NCAM1, VWF, RBP4, SELP, BMP2
44	il 1032	6.8	VDR, IL10, IL18, IL1A, IL1B, IL3
45	indomethacin32 9 9	8.8	MYC, BMP2, BIRC5, CEBPB, MPO, CDKN3
46	ccl332	6.7	IL10, IL18, IL1A, IL1B, IL6, IL8
47	nitric oxide32 9 18 9	9.4	PIK3CB, NCAM1, RB1, SELP, BMP2, BIRC5
48	simvastatin32 34 42 9 18 9	11.4	VWF, RBP4, SELP, SERPINE1, BMP2, BCHE
49	15-deoxy-delta-12,14-prostaglandin j232	5.4	PIK3CG, SERPINE1, MYC, BIRC5, BCL2L1, CDKN1A
50	actinomycin d32	4.2	PIK3CA, PIK3CG, RB1, SERPINE1, VDR, MYC

Cellular components related to acute promyelocytic leukemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:005654	9.5	NR6A1, SMAD4, FOS, CDK1, CDK4, CDKN1B
2	cell surface	GO:009986	9.2	CTSG, PLAT, PLAUR, ABCB1, ELANE, THBD
3	cytoplasm	GO:005737	9.2	BAX, XIAP, MAP2K1, CEBPB, ATG7, CDKN2B
4	external side of plasma membrane	GO:009897	9.2	FAS, ANXA5, ANPEP, IFNG, TNF, THBS1
5	nucleus	GO:005634	7.6	FAS, MAPK8, MAPK1, MAP2K1, ID1, IRF1
6	cytosol	GO:005829	7.4	ISG15, IRF1, FES, IL18, IL1A, IL1B
7	extracellular space	GO:005615	6.3	IL1B, IL3, IL5, IL6, IL6ST, IL8
8	extracellular region	GO:005576	5.9	VWF, PTHLH, TNFSF10, CAMP, CASP1, F2

Biological processes related to acute promyelocytic leukemia according to GeneDecks:

(show top 50)    (show all 68)

id	Name	GO ID	Score	Top Affiliating Genes
1	myeloid cell differentiation	GO:030099	11.0	RUNX1, PML, KAT6A, ZBTB16, PRDX3, CEBPA
2	response to lipopolysaccharide	GO:032496	10.8	STAT5B, PRDX3, THPO, SELP, CEBPB, THBD
3	peptidyl-tyrosine phosphorylation	GO:018108	10.4	LYN, WEE1, CSF1R, SRC, PTPN6, PTK2B
4	transcription initiation from RNA polymerase II promoter	GO:006367	10.3	NR1H2, HDAC1, VDR, RARG, RARA, NR6A1
5	negative regulation of transcription, DNA-dependent	GO:045892	10.2	EZH2, HDAC9, HOXA7, TNF, SPI1, PPARG
6	G1/S transition of mitotic cell cycle	GO:000082	10.2	BCL2, CDKN1B, CDKN1A, CDKN3, CDK1, WEE1
7	gene expression	GO:010467	10.2	FAS, CDKN2B, PARP1, RARB, RARS, RARA
8	leukocyte migration	GO:050900	10.1	CD34, ITGAL, ITGAM, ITGAX, ITGB1, ITGB2
9	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.1	MYC, PML, BAX, CDKN1B, FAS, F3
10	positive regulation of apoptotic process	GO:043065	10.1	RPS6, FAS, BMP2, RARG, RARB, BCL6
11	interferon-gamma-mediated signaling pathway	GO:060333	10.1	NCAM1, IRF1, PML, STAT1, HCK, PTPN6
12	positive regulation of cell migration	GO:030335	10.0	NOTCH1, THBS1, CSF1, CSF1R, LYN, PTK2B
13	virus-host interaction	GO:019048	9.9	PSMB9, STAT1, RB1, CXCR4, NUP98, STAT3
14	response to organic cyclic compound	GO:014070	9.8	CDK1, ICAM1, CASP1, NFIA, TAT, LYN
15	transforming growth factor beta receptor signaling pathway	GO:007179	9.8	SMAD4, ID1, CCL2, FOS, CDKN2B, MYC
16	induction of apoptosis by intracellular signals	GO:008629	9.8	BAX, MYC, CYCS, HRAS, CASP3, MAPK8
17	response to toxin	GO:009636	9.8	BCL2, LYN, CASP1, CCL3, CCL4, FAS
18	positive regulation of cell proliferation	GO:008284	9.7	SUZ12, NRAS, NOTCH1, KRAS, HCK, THPO
19	aging	GO:007568	9.6	TGFB1, CASP2, F3, IGFBP2, CCL5, CCL2
20	cellular response to mechanical stimulus	GO:071260	9.6	LTBR, CASP2, CASP1, ITGB1, IRF1, IL1B
21	positive regulation of gene expression	GO:010628	9.6	NCOA3, VDR, BMP2, CD34, CDK1, CD44
22	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	IL1B, TGFB1, HCK, TNF, CCL5, CCL3
23	cytokine-mediated signaling pathway	GO:019221	9.5	STAT1, IL1A, IL1B, IL5, IL6, IL6ST
24	induction of apoptosis	GO:006917	9.4	PML, CEBPB, TGFB1, THBS1, WT1, PPARG
25	cellular response to organic cyclic compound	GO:071407	9.4	BMP2, CCL3, CCL2, CEBPA, PPARG, TNF
26	fibroblast growth factor receptor signaling pathway	GO:008543	9.4	NRAS, CDK1, PRKAR1A, KRAS, MAPK1, SRC
27	innate immune response	GO:045087	9.3	MAP2K1, MAPK9, MAPK1, MAPK10, MAPK8, ISG15
28	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.3	RARG, RARB, HDAC9, SUZ12, TNF, HOXA7
29	epidermal growth factor receptor signaling pathway	GO:007173	9.3	CDKN1B, PIK3CA, PRKAR1A, MAPK1, TGFB1, KRAS
30	activation of MAPK activity	GO:000187	9.2	CXCR4, MAPK10, MAPK1, TP73, MAP2K1, PIK3CB
31	Ras protein signal transduction	GO:007265	9.0	RB1, CDKN1A, CDK1, MAPK1, MAP2K1, SRC
32	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	RAB7B, NPM1, PRDX3, TGFB1, KRAS, RPS27A
33	cell surface receptor signaling pathway	GO:007166	9.0	CBL, HRAS, PTK2B, LY6E, F2, IFNG
34	anti-apoptosis	GO:006916	9.0	HDAC1, CDK1, MPO, CEBPB, XIAP, BCL2L1
35	response to hypoxia	GO:001666	8.9	CXCR4, BMP2, BCL2, IL18, IL1A, IL1B
36	MAPK cascade	GO:000165	8.8	KRAS, CCL2, CCL3, CCL5, HRAS, TNF
37	neutrophil chemotaxis	GO:030593	8.8	PIK3CD, PIK3CG, ITGB2, IL1B, IL8, CCL2
38	nerve growth factor receptor signaling pathway	GO:048011	8.7	CDKN1B, RAPGEF1, MAPK1, PIK3CB, PIK3CA, VAV1
39	negative regulation of apoptotic process	GO:043066	8.7	PIK3CG, PCGF2, SERPINE1, MYC, BCL2, BCL2L1
40	cell cycle arrest	GO:007050	8.6	RB1, MYC, CDKN1A, CDKN2B, CDKN1B, HRAS
41	blood coagulation	GO:007596	8.6	PIK3CB, F5, F3, F2, HRAS, PTPN6
42	platelet activation	GO:030168	8.4	F5, MAPK1, IL6, LCP2, VAV1, SERPINE1
43	negative regulation of cell proliferation	GO:008285	8.4	RARG, TNF, PTK2B, PTHLH, CYP27B1, SMAD4
44	positive regulation of transcription, DNA-dependent	GO:045893	8.4	HDAC1, IL1B, IL10, IRF1, MLL, FOS
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	SERPINE1, VDR, MYC, BMP2, RARG, RARA
46	response to glucocorticoid stimulus	GO:051384	8.4	KRAS, IGFBP2, FAS, IL6, CCL5, IL10
47	apoptotic process	GO:006915	8.3	CXCR4, RPS27A, CYCS, PTPN6, PTK2B, TNF
48	response to drug	GO:042493	7.7	ICAM1, CASP1, TNF, TERF1, OTC, PPARG
49	signal transduction	GO:007165	7.7	RARB, RAPGEF1, CD33, CD34, CDK4, ITGAL
50	inflammatory response	GO:006954	7.1	IL5, IL6, IL8, CCL4, CCL2, CCL3

Molecular functions related to acute promyelocytic leukemia according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:043565	10.7	TP73, DLX4, MEIS1, SMAD4, IRF1, EZH2
2	steroid hormone receptor activity	GO:003707	10.6	THRA, RXRA, NR6A1, PPARG, RARB, RARA
3	sequence-specific DNA binding transcription factor activity	GO:003700	10.6	PCGF2, IRF1, ID1, CBL, HOXA7, TP73
4	protein heterodimerization activity	GO:046982	10.4	RXRA, RARA, BIRC5, BCL2, BCL2L1, TGFB1
5	core promoter binding	GO:001047	10.3	RB1, HDAC1, NOTCH1, SPI1, EZH2, SAFB
6	transcription factor binding	GO:008134	10.3	RARA, PARP1, CEBPA, HDAC9, HDAC1, RUNX1
7	transcription regulatory region DNA binding	GO:044212	9.9	NCOR1, BCOR, CEBPA, FOS, MLL, TP73
8	protease binding	GO:002020	9.8	ITGB1, F3, TNF, ELANE, SERPINC1, VWF
9	protein homodimerization activity	GO:042803	9.8	FLT3, BCL2, BIRC5, BMP2, VWF, ZBTB16
10	enzyme binding	GO:019899	9.0	TGFB1, NOTCH1, CAT, HDAC1, CSF3, STAT1
11	growth factor activity	GO:008083	8.7	CSF3, CSF2, CSF1, TGFB1, THPO, F2
12	cytokine activity	GO:005125	8.3	IL6, CCL4, IL5, IL3, IL1B, IL1A
13	protein binding	GO:005515	5.1	MAPK9, FLT3, IRF1, MLL, FOS, ITGB1