APL
MCID: ACT119
MIFTS: 55

Acute Promyelocytic Leukemia (APL) malady

Cancer diseases, Blood diseases categories

Summaries for Acute Promyelocytic Leukemia

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.

MalaCards: Acute Promyelocytic Leukemia, also known as leukemia, acute promyelocytic, is related to leukemia and acute leukemia. An important gene associated with Acute Promyelocytic Leukemia is RARA (retinoic acid receptor, alpha), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs cyclophosphamide and etoposide and the compounds retinoic acid and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are immune system and hematopoietic system.

NIH Rare Diseases:42 Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. it is usually marked by a translocation of chromosomes 15 and 17. acute promyelocytic leukemia usually occurs in middle-aged adults. symptoms may include both bleeding and forming blood clots. last updated: 6/23/2011

Wikipedia:63 Acute promyelocytic leukemia (APML, APL) is a subtype of acute myelogenous leukemia (AML), a cancer of... more...

Description from OMIM:46 612376

Aliases & Classifications for Acute Promyelocytic Leukemia

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60UMLS, 48Orphanet, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 44Novoseek, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
acute promyelocytic leukemia:
Age of onset: Variable


Aliases & Descriptions:

acute promyelocytic leukemia 42 22 21 48 60
leukemia, acute promyelocytic 21 46
aml m3 21 60
acute myeloid leukemia with t(15;17)(q22;q12);(pml/raralpha) and variants 48
acute myeloblastic leukemia type 3 48
leukemia promyelocytic acute 44
myeloid leukemia, acute, m3 21
leukemia, myelocytic, acute 60
m3 anll 21
apl 21


External Ids:

MESH via Orphanet35 D015473
ICD10 via Orphanet26 C92.4
SNOMED-CT via Orphanet57 28950004
UMLS via Orphanet61 C0023487
OMIM46 612376
ICD1025 C92.4

Related Diseases for Acute Promyelocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Acute Promyelocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5RARA, CYP26A1, CD33, NUMA1, ANXA8L2, ZBTB16
2acute leukemia32.5PML, CSF3, NPM1, STAT5B, FLT3, ZBTB16
3myeloid leukemia31.4FES, CSF3, NPM1, STAT5B, FLT3, CD33
4acute myeloid leukemia31.4NPM1, FLT3
5chronic myeloid leukemia30.4PML, FES, CSF3, STAT5B, FLT3, CD33
6sarcoma30.4FES
7breast cancer30.2PML, CSF3, NPM1, STAT5B, FLT3, NUMA1
8non-hodgkin lymphoma30.2PML, CSF3, NPM1, FLT3, ZBTB16
9myeloid sarcoma30.2CD33
10myelofibrosis30.2STAT5B, FLT3
11disseminated intravascular coagulation10.6
12acute monocytic leukemia10.6
13pseudotumor cerebri10.6
14central nervous system leukemia10.6
15monocytic leukemia10.6
16acute t cell leukemia10.5
17childhood leukemia10.5
18acute myeloblastic leukemia type 310.5
19multiple sclerosis10.4
20alpha chain disease10.4
21hypercalcemia10.4
22hepatitis10.4
23stroke, ischemic10.3
24hemophagocytic lymphohistiocytosis10.3
25leukostasis10.3
26acute myocardial infarction10.3
27aplastic anemia10.3
28aspergillosis10.3
29dermatitis10.3
30meningitis10.3
31myocardial infarction10.3
32leukemia, acute promyelocytic, npm/rara type10.3
33leukemia, acute promyelocytic, numa/rara type10.3
34leukemia, acute promyelocytic, pl2f/rara type10.3
35leukemia, acute promyelocytic, pml/rara type10.3
36leukemia, acute promyelocytic, stat5b/rara type10.3
37cerebral creatine deficiency syndrome10.2
38familial platelet disorder with associated myeloid malignancy10.2
39activated pi3k-delta immunodeficiency syndrome10.2
40inherited acute myeloid leukemia10.2
41lymphoid leukemia10.1
42acute thyroiditis10.1
43paralytic ileus10.1
44balanoposthitis10.1
45focal segmental glomerulosclerosis10.1
46leukemoid reaction10.1
47papillary carcinoma10.1
48granulomatous dermatitis10.1
49pulmonary edema10.1
50cellulitis10.1

Graphical network of the top 20 diseases related to Acute Promyelocytic Leukemia:



Diseases related to acute promyelocytic leukemia

Clinical Features for Acute Promyelocytic Leukemia

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Sources:
46OMIM
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Clinical features from OMIM:

612376

Drugs & Therapeutics for Acute Promyelocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Promyelocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Promyelocytic Leukemia

Search NIH Clinical Center for Acute Promyelocytic Leukemia

Search CenterWatch for Acute Promyelocytic Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Acute Promyelocytic Leukemia

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22GTR
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Genetic tests related to Acute Promyelocytic Leukemia:

id Genetic test Affiliating Genes
1 Acute Promyelocytic Leukemia22

Anatomical Context for Acute Promyelocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute Promyelocytic Leukemia:

32
Myeloid, Bone marrow, Bone

Animal Models for Acute Promyelocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Promyelocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.3RARA, PML, FES, CSF3, NPM1, STAT5B
2MP:000539711.2PML, FES, CSF3, NPM1, STAT5B, FLT3
3MP:000538411.1PML, UBA7, FES, NPM1, STAT5B, FLT3
4MP:000287311.0UBA7, FES, CRABP1, STAT5B, CYP26A1, RARA
5MP:000200610.6PML, FES, NPM1, STAT5B, FLT3, RARA

Publications for Acute Promyelocytic Leukemia

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Genetic Variations for Acute Promyelocytic Leukemia

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Expression for genes affiliated with Acute Promyelocytic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Promyelocytic Leukemia

Search GEO for disease gene expression data for Acute Promyelocytic Leukemia.

Pathways for genes affiliated with Acute Promyelocytic Leukemia

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Sources:
29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PML, STAT5B, FLT3, ZBTB16, RARA
2
Hide members
10.9RARA, ZBTB16, FLT3, STAT5B, PML
310.8PML, FLT3, ZBTB16, RARA
410.7RARA, CYP26A1, STAT5B
510.7FES, STAT5B, RARA
610.7FLT3, NPM1, FES
710.7RARA, CYP26A1, CRABP1
810.7CD33, FLT3, CSF3

Compounds for genes affiliated with Acute Promyelocytic Leukemia

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1retinoic acid44 2413.0RARA, PML, UBA7, FES, CSF3, TNFAIP2
2tyrosine4411.3FES, CSF3, NPM1, STAT5B, FLT3, ZBTB16
3retinoid4411.3PML, UBA7, CRABP1, ZBTB16, CYP26A1, RARA
4imatinib44 49 1113.1CSF3, STAT5B, FLT3, RARA
5arsenite44 2412.1PML, STAT5B, FLT3, RARA
6Etretinate1111.1CRABP1, CYP26A1, RARA
7gemtuzumab ozogamicin44 1112.1CD33, FLT3, CSF3
8acitretin44 1112.1CRABP1, CYP26A1, RARA
9tretinoin49 1112.0RARA, CRABP1, PML
10nitroblue tetrazolium4411.0CSF3, CD33, RARA
11isotretinoin44 1112.0RARA, CYP26A1, CRABP1
12alpha-retinoic acid4411.0RARA, PML
13etoposide44 49 59 1114.0RARA, FLT3, CSF3, PML
14daniplestim4410.9CSF3, FLT3
15ttab4410.9CYP26A1, RARA
16daunorubicin44 49 1112.9CSF3, NPM1, FLT3
17ch 554410.9RARA, CRABP1
18am 5804410.9RARA, CYP26A1
19am804410.9CRABP1, RARA
20Alitretinoin1110.8CRABP1, RARA
21paclitaxel44 49 1112.8CSF3, NPM1, RARA
22pixy3214410.7FLT3, CSF3
23arsenic trioxide49 1111.6RARA, PML
24retinaldehyde4410.6RARA, CYP26A1
25gp 1304410.6CSF3, STAT5B, FLT3
26idarubicin44 49 1112.3FLT3, CSF3

GO Terms for genes affiliated with Acute Promyelocytic Leukemia

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16Gene Ontology
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Biological processes related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:00828511.0CD33, ZBTB16, FLT3, NPM1, PML
2retinoic acid receptor signaling pathwayGO:04838410.9RARA, CYP26A1, PML
3cytokine-mediated signaling pathwayGO:01922110.8FLT3, CSF3, UBA7, PML
4positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.8CSF3, FLT3, RARA
5myeloid cell differentiationGO:03009910.6ZBTB16, PML
6positive regulation of actin cytoskeleton reorganizationGO:200025110.5FES, CSF3
7cellular response to cytokine stimulusGO:07134510.3FLT3, CSF3

Molecular functions related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid bindingGO:00197210.7RARA, CYP26A1, CRABP1

Products for genes affiliated with Acute Promyelocytic Leukemia

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  • Antibodies
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  • Antibodies

Sources for Acute Promyelocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet