APL
MCID: ACT119
MIFTS: 64

Acute Promyelocytic Leukemia (APL) malady

Cancer, Blood categories

Summaries for Acute Promyelocytic Leukemia

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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Genetics Home Reference:21 Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.

MalaCards: Acute Promyelocytic Leukemia, also known as leukemia, acute promyelocytic, is related to acute leukemia and acute myeloid leukemia. An important gene associated with Acute Promyelocytic Leukemia is RARA (retinoic acid receptor, alpha), and among its related pathways are Endometrial cancer and Pathways in cancer. The drugs cyclophosphamide and etoposide and the compounds retinoic acid and retinoid have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone marrow, and related mouse phenotypes are immune system and cellular.

NIH Rare Diseases:43 Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. it is usually marked by a translocation of chromosomes 15 and 17. acute promyelocytic leukemia usually occurs in middle-aged adults. symptoms may include both bleeding and forming blood clots. last updated: 6/23/2011

Wikipedia:64 Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia (AML), a cancer of the blood and... more...

Description from OMIM:47 612376

Aliases & Classifications for Acute Promyelocytic Leukemia

Sources:
43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 47OMIM, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
acute promyelocytic leukemia:
Age of onset: Variable


Aliases & Descriptions:

acute promyelocytic leukemia 43 22 21 49 61
leukemia, acute promyelocytic 21 47
aml m3 21 61
acute myeloid leukemia with t ; and variants 49
acute myeloblastic leukemia type 3 49
leukemia promyelocytic acute 45
myeloid leukemia, acute, m3 21
leukemia, myelocytic, acute 61
m3 anll 21
apl 21


External Ids:

MESH via Orphanet36 D015473
ICD10 via Orphanet26 C92.4
SNOMED-CT via Orphanet58 28950004
UMLS via Orphanet62 C0023487
OMIM47 612376
ICD1025 C92.4

Related Diseases for Acute Promyelocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acute Promyelocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.5PML, CSF3, NPM1, STAT5B, FLT3, ZBTB16
2acute myeloid leukemia31.4NPM1, FLT3
3chronic myeloid leukemia30.5PML, FES, CSF3, STAT5B, FLT3, CD33
4myelodysplastic syndromes30.2CSF3, NPM1, FLT3, CD33, RARA
5myeloproliferative disorder30.2CSF3, STAT5B, FLT3
6myeloid sarcoma30.2CD33
7chronic myelomonocytic leukemia30.2FLT3, CSF3
8refractory anemia30.2FLT3, CSF3
9acute t cell leukemia11.2
10t-cell leukemia11.2
11pseudotumor cerebri10.6
12central nervous system leukemia10.6
13acute monocytic leukemia10.6
14leukemia, acute myeloid, therapy-related10.6
15bone marrow necrosis10.6
16acute myeloblastic leukemia type 310.5
17alpha chain disease10.4
18hypercalcemia10.4
19leukemia, acute pre-b-cell10.4
20hematopoietic stem cell transplantation10.4
21stroke, ischemic10.3
22hemophagocytic lymphohistiocytosis10.3
23leukostasis10.3
24acute myocardial infarction10.3
25aplastic anemia10.3
26aspergillosis10.3
27acute myelomonocytic leukemia10.3
28leukemia, acute promyelocytic, npm/rara type10.3
29leukemia, acute promyelocytic, numa/rara type10.3
30leukemia, acute promyelocytic, pl2f/rara type10.3
31leukemia, acute promyelocytic, pml/rara type10.3
32leukemia, acute promyelocytic, stat5b/rara type10.3
33polyploidy10.3
34familial platelet disorder with associated myeloid malignancy10.2
35activated pi3k-delta immunodeficiency syndrome10.2
36inherited acute myeloid leukemia10.2
37lymphoid leukemia10.2
38paralytic ileus10.2
39balanoposthitis10.2
40focal segmental glomerulosclerosis10.2
41leukemoid reaction10.2
42papillary carcinoma10.2
43granulomatous dermatitis10.2
44pulmonary edema10.2
45cellulitis10.2
46adult t-cell leukemia10.2
47thrombocytosis10.2
48natural killer cell leukemia10.2
49splenic infarction10.2
50hyperhomocysteinemia10.2

Graphical network of the top 20 diseases related to Acute Promyelocytic Leukemia:



Diseases related to acute promyelocytic leukemia

Clinical Features for Acute Promyelocytic Leukemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

612376

Drugs & Therapeutics for Acute Promyelocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Promyelocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute Promyelocytic Leukemia

Search NIH Clinical Center for Acute Promyelocytic Leukemia

Search CenterWatch for Acute Promyelocytic Leukemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Acute Promyelocytic Leukemia

Sources:
22GTR
See all sources

Genetic tests related to Acute Promyelocytic Leukemia:

id Genetic test Affiliating Genes
1 Acute Promyelocytic Leukemia22

Anatomical Context for Acute Promyelocytic Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Promyelocytic Leukemia:

33
Liver, Kidney, Bone marrow, Whole blood, Heart, Small intestine, Colon, Adipocyte, Thyroid, Breast, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Acute Promyelocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Promyelocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.3RARA, PML, FES, CSF3, NPM1, STAT5B
2MP:000538411.2UBA7, FES, NPM1, STAT5B, FLT3, ZBTB16
3MP:000539711.2PML, FES, CSF3, NPM1, STAT5B, FLT3
4MP:000200610.8PML, FES, NPM1, STAT5B, FLT3, RARA
5MP:000287310.7PML, UBA7, FES, CRABP1, STAT5B, CYP26A1

Publications for Acute Promyelocytic Leukemia

Sources:
51PubMed
See all sources

Articles related to Acute Promyelocytic Leukemia:

(show top 50)    (show all 1023)
idTitleAuthorsYear
1
Overexpression of SNORD114-3 marks acute promyelocytic leukemia. (23979522)
2014
2
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. (23841729)
2013
3
A novel acidic serine protease, ASPNJ inhibits proliferation, induces apoptosis and enhances chemo-susceptibility of acute promyelocytic leukemia cell. (24169085)
2013
4
Overcoming treatment resistance in acute promyelocytic leukemia and beyond. (23934744)
2013
5
8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARI+ degradation. (23382200)
2013
6
Modified array-based comparative genomic hybridization detects cryptic and variant PML-RARA rearrangements in acute promyelocytic leukemia lacking classic translocations. (23370423)
2013
7
Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia? (23894153)
2013
8
Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical results and open questions. (24053202)
2013
9
Molecular characteristics and chromatin texture features in acute promyelocytic leukemia. (22742960)
2012
10
Management of acute promyelocytic leukemia: implications for treatment of other cancers. (22888565)
2012
11
Retrospective analysis of 119 cases of pediatric acute promyelocytic leukemia: Comparisons of four treatment regimes. (23060929)
2012
12
A malignant case of acute promyelocytic leukemia with occlusion of carotid artery by tumor thrombus. (22182759)
2012
13
Undiagnosed, untreated acute promyelocytic leukemia presenting as a suspicious sudden death. (22292852)
2012
14
Gluthatione-S-transferase T1-null genotype predisposes adults to acute promyelocytic leukemia; a case-control study. (21875282)
2011
15
Inhibition of PCGF2 enhances granulocytic differentiation of acute promyelocytic leukemia cell line HL-60 via induction of HOXA7. (22085718)
2011
16
Long-term remission after first-line single-agent treatment with arsenic trioxide of relapsed acute promyelocytic leukemia in an 8-year-old boy. (21345080)
2011
17
Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the Swedish Adult Acute Leukemia Registry. (21502956)
2011
18
Treatment of relapsed acute promyelocytic leukemia by arsenic trioxide in Iran. (21529103)
2011
19
Efficacy of prolonged therapy with combined arsenic trioxide and ATRA for relapse of acute promyelocytic leukemia. (21659361)
2011
20
External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature. (20186102)
2010
21
Phosphatidylserine exposure and procoagulant activity in acute promyelocytic leukemia. (20102487)
2010
22
Acute promyelocytic leukemia at time of relapse commonly demonstrates cytogenetic evidence of clonal evolution and variability in blast immunophenotypic features. (20154288)
2010
23
PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia. (20159609)
2010
24
Acute promyelocytic leukemia in HIV-infected adults: a case report and review of therapeutic considerations. (21856551)
2010
25
Clinical outcome of patients with acute promyelocytic leukemia and FLT3 mutations. (20981678)
2010
26
Single cycle of arsenic trioxide-based consolidation chemotherapy spares anthracycline exposure in the primary management of acute promyelocytic leukemia. (20085935)
2010
27
Cryptic insertion of PML-RARA into the 3p25 locus in an acute promyelocytic leukemia with t(3;17)(p25;q21). (20633765)
2010
28
Rational targeting in acute promyelocytic leukemia. (20133971)
2010
29
Molecular or cytogenetic monitoring and preemptive therapy for central nervous system relapse of acute promyelocytic leukemia. (20065085)
2010
30
A case of fatal overwhelming microgranular variant (M3v) of acute promyelocytic leukemia with extensive extramedullary involvement. (20213115)
2010
31
Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells through mitochondria-dependent pathway. (19544974)
2009
32
Induction of dendritic cells derived from acute promyelocytic leukemia cells by all trans retinoic acid]. (18928613)
2008
33
The genetic characterization of acute promyelocytic leukemia with cryptic t(15;17) including a new recurrent additional cytogenetic abnormality i(17)(q10). (17943164)
2008
34
New therapeutic perspectives for arsenic: from acute promyelocytic leukemia to autoimmune diseases]. (19038100)
2008
35
Overexpression of BP1, a homeobox gene, is associated with resistance to all-trans retinoic acid in acute promyelocytic leukemia cells. (18026954)
2008
36
Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. (16140955)
2005
37
PML/RARalpha plays a role for basal activity and retinoid-induced repression of the tissue factor promoter in acute promyelocytic leukemia cells. (14597990)
2003
38
Clonal evolution of blasts in an elderly patient with CD56(+) relapsed acute promyelocytic leukemia. (11835333)
2002
39
Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid. (12443882)
2002
40
The impact of arsenic trioxide or all-trans retinoic acid treatment on coagulopathy in acute promyelocytic leukemia]. (16206674)
2001
41
The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases. (9920855)
1999
42
A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation. (9192750)
1997
43
Study of dominant negative effect of the PLZF-RARalpha against the wild-type RARalpha in acute promyelocytic leukemia]. (15622742)
1997
44
Stat1 is induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells. (9028332)
1997
45
Treatment of acute promyelocytic leukemia--combined use of all-trans retinoic acid and granulocyte colony-stimulating factor]. (7543953)
1995
46
Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RAR-alpha protein. (7620182)
1995
47
Retinoic acid and acute promyelocytic leukemia: a model of targetting treatment for human cancer. (7697468)
1994
48
Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia. (1323928)
1992
49
A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia. (6589608)
1984
50
Acute promyelocytic transformation in a case of acute myelomonocytic leukemia. (6589037)
1984

Genetic Variations for Acute Promyelocytic Leukemia

Expression for genes affiliated with Acute Promyelocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Promyelocytic Leukemia

Search GEO for disease gene expression data for Acute Promyelocytic Leukemia.

Pathways for genes affiliated with Acute Promyelocytic Leukemia

Sources:
30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Pathways related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9RARA, ZBTB16, FLT3, STAT5B, PML
210.9PML, STAT5B, FLT3, ZBTB16, RARA
310.8PML, FLT3, ZBTB16, RARA
410.7RARA, CYP26A1, STAT5B
510.7FES, STAT5B, RARA
610.7FLT3, NPM1, FES
710.7RARA, CYP26A1, CRABP1
810.7CD33, FLT3, CSF3

Compounds for genes affiliated with Acute Promyelocytic Leukemia

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.9RARA, PML, UBA7, FES, CSF3, TNFAIP2
2retinoid4511.3PML, UBA7, CRABP1, ZBTB16, CYP26A1, RARA
3tyrosine4511.3FES, CSF3, NPM1, STAT5B, FLT3, ZBTB16
4imatinib45 50 1113.1CSF3, STAT5B, FLT3, RARA
5Etretinate1111.1CRABP1, CYP26A1, RARA
6arsenite45 2412.1PML, STAT5B, FLT3, RARA
7gemtuzumab ozogamicin45 1112.1CD33, FLT3, CSF3
8acitretin45 1112.0CRABP1, CYP26A1, RARA
9tretinoin50 1112.0RARA, CRABP1, PML
10nitroblue tetrazolium4511.0CSF3, CD33, RARA
11isotretinoin45 1112.0RARA, CYP26A1, CRABP1
12alpha-retinoic acid4511.0RARA, PML
13etoposide45 50 60 1113.9RARA, FLT3, CSF3, PML
14ttab4510.9RARA, CYP26A1
15daniplestim4510.9FLT3, CSF3
16am 5804510.9CYP26A1, RARA
17daunorubicin45 50 1112.9CSF3, NPM1, FLT3
18ch 554510.9CRABP1, RARA
19am804510.9RARA, CRABP1
20Alitretinoin1110.7CRABP1, RARA
21pixy3214510.7FLT3, CSF3
22arsenic trioxide50 1111.6RARA, PML
23retinaldehyde4510.6RARA, CYP26A1
24gp 1304510.6CSF3, STAT5B, FLT3
25idarubicin45 50 1112.3FLT3, CSF3

GO Terms for genes affiliated with Acute Promyelocytic Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:00828511.0CD33, ZBTB16, FLT3, NPM1, PML
2retinoic acid receptor signaling pathwayGO:04838410.9RARA, CYP26A1, PML
3cytokine-mediated signaling pathwayGO:01922110.8FLT3, CSF3, UBA7, PML
4positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.8CSF3, FLT3, RARA
5myeloid cell differentiationGO:03009910.6ZBTB16, PML
6positive regulation of actin cytoskeleton reorganizationGO:200025110.5FES, CSF3
7cellular response to cytokine stimulusGO:07134510.3FLT3, CSF3

Molecular functions related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid bindingGO:00197210.7RARA, CYP26A1, CRABP1

Products for genes affiliated with Acute Promyelocytic Leukemia

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Sources for Acute Promyelocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet