APL
MCID: ACT119
MIFTS: 66

Acute Promyelocytic Leukemia (APL) malady

Rare diseases, Cancer diseases, Blood diseases categories
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Summaries for Acute Promyelocytic Leukemia

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43NIH Rare Diseases, 21Genetics Home Reference, 65Wikipedia, 47OMIM, 33MalaCards
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Genetics Home Reference:21 Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.

MalaCards: Acute Promyelocytic Leukemia, also known as leukemia, acute promyelocytic, is related to leukemia and acute myeloid leukemia. An important gene associated with Acute Promyelocytic Leukemia is RARA (retinoic acid receptor, alpha), and among its related pathways are Nuclear receptors in lipid metabolism and toxicity and Adipogenesis. The drugs cyclophosphamide and etoposide and the compounds alpha-retinoic acid and ttab have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related mouse phenotypes are reproductive system and tumorigenesis.

NIH Rare Diseases:43 Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. it is usually marked by a translocation of chromosomes 15 and 17. acute promyelocytic leukemia usually occurs in middle-aged adults. symptoms may include both bleeding and forming blood clots. last updated: 6/23/2011

Wikipedia:65 Acute promyelocytic leukemia (APML, APL) is a subtype of acute myelogenous leukemia (AML), a cancer of... more...

Description from OMIM:47 612376

Aliases & Classifications for Acute Promyelocytic Leukemia

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43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 47OMIM, 45Novoseek, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

49
acute promyelocytic leukemia:
Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

acute promyelocytic leukemia 43 22 21 49 62
leukemia, acute promyelocytic 21 47
aml m3 21 62
acute myeloid leukemia with t(15;17)(q22;q12);(pml/raralpha) and variants 49
acute myeloblastic leukemia type 3 49
leukemia promyelocytic acute 45
myeloid leukemia, acute, m3 21
leukemia, myelocytic, acute 62
m3 anll 21
apl 21


External Ids:

MESH via Orphanet36 D015473
ICD10 via Orphanet26 C92.4
SNOMED-CT via Orphanet59 28950004
UMLS via Orphanet63 C0023487
OMIM47 612376
ICD1025 C92.4

Related Diseases for Acute Promyelocytic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Acute Promyelocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.3FES, PML, NUMA1, CYP26A1, ZBTB16, FLT3
2acute myeloid leukemia31.3NPM1, FLT3
3myeloid leukemia31.3FES, FLT3, STAT5B, RARA, NPM1, CD33
4myelodysplastic syndromes30.9FLT3, RARA, NPM1, CD33
5acute leukemia30.6ZBTB16, PML, FLT3, STAT5B, RARA, NPM1
6chronic myeloid leukemia30.6PML, FES, FLT3, STAT5B, RARA, CD33
7myeloid sarcoma30.5CD33
8non-hodgkin lymphoma30.4ZBTB16, PML, FLT3, NPM1
9myelofibrosis30.3STAT5B, FLT3
10breast cancer30.2CYP26A1, NUMA1, PML, FLT3, PRKAR1A, STAT5B
11disseminated intravascular coagulation10.7
12pseudotumor cerebri10.6
13bone marrow necrosis10.6
14multiple sclerosis10.5
15endotheliitis10.5
16hematopoietic stem cell transplantation10.5
17acute myeloblastic leukemia type 310.5
18hypercalcemia10.4
19hepatitis10.4
20leukostasis10.3
21hemophagocytic lymphohistiocytosis10.3
22aplastic anemia10.3
23aspergillosis10.3
24dermatitis10.3
25meningitis10.3
26myocardial infarction10.3
27sarcoma10.3
28ring chromosome 610.3
29leukemia, acute promyelocytic, npm/rara type10.3
30leukemia, acute promyelocytic, numa/rara type10.3
31leukemia, acute promyelocytic, pl2f/rara type10.3
32leukemia, acute promyelocytic, pml/rara type10.3
33leukemia, acute promyelocytic, stat5b/rara type10.3
34polyploidy10.3
35focal segmental glomerulosclerosis10.2
36natural killer cell leukemia10.2
37splenic infarction10.2
38hyperhomocysteinemia10.2
39appendicitis10.2
40paralytic ileus10.2
41hepatitis b10.2
42placental abruption10.2
43noma10.2
44herpes zoster10.2
45septic arthritis10.2
46hepatic vein thrombosis10.2
47leukemoid reaction10.2
48granulomatous dermatitis10.2
49pulmonary edema10.2
50cerebritis10.2

Graphical network of the top 20 diseases related to Acute Promyelocytic Leukemia:



Diseases related to acute promyelocytic leukemia

Symptoms for Acute Promyelocytic Leukemia

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47OMIM
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Clinical features from OMIM:

612376

Drugs & Therapeutics for Acute Promyelocytic Leukemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Acute Promyelocytic Leukemia

Search NIH Clinical Center for Acute Promyelocytic Leukemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Acute Promyelocytic Leukemia

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22GTR
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Genetic tests related to Acute Promyelocytic Leukemia:

id Genetic test Affiliating Genes
1 Acute Promyelocytic Leukemia22

Anatomical Context for Acute Promyelocytic Leukemia

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33MalaCards
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MalaCards organs/tissues related to Acute Promyelocytic Leukemia:

33
Myeloid, Bone, Bone marrow, Monocytes, Liver, Endothelial, Thyroid, Colon, Kidney, Adipocyte, Breast, Heart, T cells

Animal Models for Acute Promyelocytic Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Acute Promyelocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.9CYP26A1, FES, PRKAR1A, STAT5B, RARA, ZBTB16
2MP:00020069.9NPM1, ZBTB16, PML, FES, FLT3, PRKAR1A
3MP:00028739.7CYP26A1, PML, FES, PRKAR1A, STAT5B, CRABP1
4MP:00053849.7ZBTB16, CYP26A1, NUMA1, PML, FLT3, PRKAR1A
5MP:00053979.6ZBTB16, PML, FES, FLT3, PRKAR1A, STAT5B
6MP:00053879.5ZBTB16, PML, FES, FLT3, PRKAR1A, STAT5B
7MP:00107689.2CYP26A1, NUMA1, PML, FES, FLT3, PRKAR1A

Publications for Acute Promyelocytic Leukemia

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52PubMed
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Articles related to Acute Promyelocytic Leukemia:

(show top 50)    (show all 998)
idTitleAuthorsYear
1
A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia. (24422201)
2014
2
Role of hematopoietic stem cell transplantation for relapsed acute promyelocytic leukemia: a retrospective analysis of JALSG-APL97. (23837667)
2013
3
Hepatotoxicity from arsenic trioxide for pediatric acute promyelocytic leukemia. (23412590)
2013
4
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. (23518351)
2013
5
Rare occurrence of the JAK1 mutation in acute promyelocytic leukemia patients. (23860541)
2013
6
A unique PML-RARI+ rearrangement involving chromosomes 11, 15, and 17 in a patient with acute promyelocytic leukemia. (23660071)
2013
7
Single-Agent Liposomal All-Trans-Retinoic Acid as Initial Therapy for Acute Promyelocytic Leukemia: 13-Year Follow-Up Data. (24128595)
2013
8
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. (23841729)
2013
9
ZBTB16-RARI+ variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature. (23071480)
2012
10
Long term curative effects of sequential therapy with all-trans retinoic acid, arsenious oxide and chemotherapy on patients with acute promyelocytic leukemia. (23168069)
2012
11
FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: a report from the Children's Oncology Group. (22378655)
2012
12
High incidence of acute promyelocytic leukemia specifically induced by N-nitroso-N-methylurea (NMU) in Sprague-Dawley rats. (21964634)
2012
13
Speciation of arsenic trioxide metabolites in peripheral blood and bone marrow from an acute promyelocytic leukemia patient. (22272800)
2012
14
AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance. (21385856)
2011
15
A novel PML-ADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia. (21529941)
2011
16
Increased incidence of central nervous system hemorrhages in patients with secondary acute promyelocytic leukemia after treatment of multiple sclerosis with mitoxantrone? (21632839)
2011
17
Acute Budd-Chiari syndrome in pediatric acute promyelocytic leukemia. (21649539)
2011
18
Treatment of therapy related acute promyelocytic leukemia with the combination of all trans retinoic acid and arsenic trioxide without chemotherapy: a series of three patients. (20350274)
2010
19
Acute promyelocytic leukemia occurring in a previously healthy bone marrow donor. (20620606)
2010
20
External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature. (20186102)
2010
21
A case of ischemic stroke in acute promyelocytic leukemia at initial presentation. Relevance of all-trans retinoic acid treatment. (20041837)
2010
22
Isolated bowel relapse in acute promyelocytic leukemia: an unusual site of extramedullary recurrence. (20713873)
2010
23
Autologous stem cell transplantation for patients with acute promyelocytic leukemia in second molecular remission. (20944181)
2010
24
FLT3 internal tandem duplication in patients with acute promyelocytic leukemia]. (17939400)
2007
25
CD2+ tetraploid acute promyelocytic leukemia variant with double (15;17) translocations. (15717685)
2005
26
Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression. (14645547)
2003
27
New highly sensitive fluorescence in situ hybridization method to detect PML/RARA fusion in acute promyelocytic leukemia. (12935927)
2003
28
The impact of arsenic trioxide or all-trans retinoic acid treatment on coagulopathy in acute promyelocytic leukemia]. (16206674)
2001
29
Effects of all-trans-retinoic acid and arsenic trioxide on the hemostatic disturbance associated with acute promyelocytic leukemia. (11369412)
2001
30
Pseudotumor cerebri induced by all-trans-retinoic acid in a child treated for acute promyelocytic leukemia. (10742073)
2000
31
Annexin II and bleeding in acute promyelocytic leukemia. (10099141)
1999
32
Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-trans retinoic acid and granulocyte colony-stimulating factor. (10381496)
1999
33
Terminal deletion of the long arm of chromosome 9 in acute promyelocytic leukemia with a cryptic PML/RAR alpha rearrangement. (10484977)
1999
34
The role of von Willebrand factor in the hemostatic defect of acute promyelocytic leukemia. (9922039)
1998
35
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. (9122233)
1997
36
All-trans retinoic acid-induced myelomonocytoid differentiation in acute promyelocytic leukemia]. (9194390)
1997
37
Variant and masked translocations in acute promyelocytic leukemia. (8819070)
1996
38
The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. (8562957)
1996
39
PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia. (8952164)
1996
40
Acute promyelocytic leukemia with t(15;16;17;19) and unusual fluorescence in situ hybridization pattern with PML and RARA probes. (8956873)
1996
41
Loss of blast cell procoagulant activity and improvement of hemostatic variables in patients with acute promyelocytic leukemia administered all-trans-retinoic acid. (7620161)
1995
42
Retinoic acid and acute promyelocytic leukemia: a model of targetting treatment for human cancer. (7697468)
1994
43
The t(15;17) translocation in acute promyelocytic leukemia. (7934155)
1994
44
Retinoic acid receptors: involvement in acute promyelocytic leukemia. (7920173)
1994
45
Interstitial insertion of retinoic acid receptor-alpha gene in acute promyelocytic leukemia with normal chromosomes 15 and 17. (8180390)
1994
46
A non-classical translocation involving 17q12 (retinoic acid receptor alpha) in acute promyelocytic leukemia (APML) with atypical features. (8057672)
1994
47
Hypercalcemia associated with all-trans-retinoic acid in the treatment of acute promyelocytic leukemia. (8501972)
1993
48
Molecular heterogeneity of the PML gene rearrangement in acute promyelocytic leukemia: prevalence and clinical significance. (8387477)
1993
49
Retinoic acid receptor alpha in acute promyelocytic leukemia. (8391236)
1993
50
Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia. (7680887)
1993

Variations for Acute Promyelocytic Leukemia

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Expression for genes affiliated with Acute Promyelocytic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Promyelocytic Leukemia

Search GEO for disease gene expression data for Acute Promyelocytic Leukemia.

Pathways for genes affiliated with Acute Promyelocytic Leukemia

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50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 55Reactome, 30KEGG, 60Thomson Reuters
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Pathways related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3RARA, CYP26A1
210.2RARA, STAT5B, CYP26A1
310.2RARA, STAT5B, FES
410.2FES, FLT3, NPM1
5
Show member pathways
10.1RARA, CRABP1, CYP26A1
610.1ZBTB16, PML, FLT3, RARA
7
Show member pathways
Signal transduction PTEN pathway60
10.1RARA, STAT5B, FLT3, PML, ZBTB16
810.1ZBTB16, PML, FLT3, STAT5B, RARA

Compounds for genes affiliated with Acute Promyelocytic Leukemia

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1alpha-retinoic acid4510.6RARA, PML
2ttab4510.6RARA, CYP26A1
3am 5804510.5CYP26A1, RARA
4ch 554510.5CRABP1, RARA
5arsenic trioxide51 1111.5RARA, PML
6tretinoin51 1111.5RARA, CRABP1, PML
7am804510.5RARA, CRABP1
8acitretin45 1111.5CYP26A1, CRABP1, RARA
9isotretinoin45 1111.5CYP26A1, CRABP1, RARA
10arsenite45 2411.4PML, FLT3, STAT5B, RARA
11imatinib45 51 1112.4FLT3, FIP1L1, STAT5B, RARA
12retinaldehyde4510.4RARA, CYP26A1
13gemtuzumab ozogamicin51 45 1112.3CD33, FLT3
14nitroblue tetrazolium4510.3RARA, CD33
15zinc45 2411.2ZBTB16, PML, STAT5B, RARA, NPM1
16retinoid4510.2ZBTB16, CYP26A1, PML, CRABP1, RARA, UBA7
17vitamin a45 24 1112.1RARA, CRABP1, CYP26A1
18threonine4510.1NUMA1, FES, FLT3, STAT5B, NPM1
19tyrosine4510.0ZBTB16, FES, FLT3, FIP1L1, STAT5B, RARA
20cysteine459.9NPM1, UBA7, RARA, PRKAR1A, PML
21calcium45 51 24 1112.8CLEC11A, PRKAR1A, ANXA8L2, ANXA8, CRABP1, RARA
22cycloheximide459.8TNFAIP2, STAT5B, RARA, NPM1
23retinoic acid45 2410.4NPM1, ZBTB16, CYP26A1, NUMA1, PML, TNFAIP2

GO Terms for genes affiliated with Acute Promyelocytic Leukemia

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16Gene Ontology
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Cellular components related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.1NPM1, RARA, STAT5B, PML, NUMA1
2cytosolGO:0058299.2NPM1, ZBTB16, NUMA1, PML, FES, PRKAR1A

Biological processes related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1retinoic acid receptor signaling pathwayGO:04838410.1CYP26A1, PML, RARA
2myeloid cell differentiationGO:03009910.0PML, ZBTB16
3signal transductionGO:00716510.0CD33, NPM1, RARA, CRABP1, PRKAR1A
4negative regulation of cell proliferationGO:0082859.9CD33, NPM1, RARA, FLT3, PML, ZBTB16

Molecular functions related to Acute Promyelocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-dependent phospholipid bindingGO:00554410.2ANXA8, ANXA8L2
2retinoic acid bindingGO:00197210.1RARA, CRABP1, CYP26A1
3protein bindingGO:0055159.1ZBTB16, NUMA1, PML, FES, FLT3, PRKAR1A

Products for genes affiliated with Acute Promyelocytic Leukemia

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Sources for Acute Promyelocytic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet