MCID: ACT080
MIFTS: 31

Acute Pulmonary Heart Disease malady

Categories: Cardiovascular diseases

Aliases & Classifications for Acute Pulmonary Heart Disease

Aliases & Descriptions for Acute Pulmonary Heart Disease:

Name: Acute Pulmonary Heart Disease 12 14 69
Acute Pulmonary Heart Disease Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8514
ICD9CM 35 415
UMLS 69 C0155671

Summaries for Acute Pulmonary Heart Disease

MalaCards based summary : Acute Pulmonary Heart Disease, also known as acute pulmonary heart disease nos, is related to inferolateral myocardial infarct and unilateral multicystic dysplastic kidney. An important gene associated with Acute Pulmonary Heart Disease is POR (Cytochrome P450 Oxidoreductase), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Folate Metabolism. The drugs Heparin and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotype is cardiovascular system.

Related Diseases for Acute Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Acute Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 inferolateral myocardial infarct 10.3 NPPB PLAT
2 unilateral multicystic dysplastic kidney 10.3 NPPB PLAT
3 myxoid chondrosarcoma 10.3 NPPB PLAT
4 peanut allergy 10.2 PLAT SERPINF2
5 cerebral calcifications opalescent teeth phosphaturia 10.2 PLAT SERPINE1
6 brazilian hemorrhagic fever 10.2 PLAT SERPINE1
7 inherited blood coagulation disease 10.2 SERPINE1 SERPINF2
8 ductal carcinoma in situ 10.2 PLAT SERPINF2
9 inflammatory bowel disease 11 10.1 PLAT SERPINE1 SERPINF2
10 microphthalmia, isolated, with coloboma 10 10.1 SERPINE1 VCL
11 secretory diarrhea myopathy and deafness 10.1 PLAT SERPINE1 SERPINF2
12 lynch syndrome 10.1 PLAT SERPINE1 SERPINF2
13 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.1 ADAM17 WDFY2
14 brill-zinsser disease 10.1 PLAT SERPINE1 SERPINF2
15 pericardium disease 10.1 NPPB PDZK1IP1
16 testicular pure germ cell tumor 10.1 NPPB PDZK1IP1
17 monocular exotropia 10.1 PLAT SERPINE1
18 pyrimidine metabolic disorder 10.1 NPPB PLAT SERPINE1
19 long qt syndrome 9 10.1 NEXN NPPB VCL
20 linear scleroderma 10.1 PLAT PLG
21 miller-dieker lissencephaly syndrome 10.1 PLG SERPINF2
22 influenza 10.1 PLG SERPINF2
23 mixed hepatoblastoma 10.0 PLG SERPINF2
24 leukocyte disease 10.0 NPPB PLAT SERPINE1 SERPINF2
25 adult t-cell leukemia 10.0 NPPB PLAT SERPINE1 SERPINF2
26 blackwater fever 10.0 PLG SERPINF2
27 generalized anxiety disorder 10.0 PLG SERPINE1
28 midline cystocele 10.0 PLG SERPINE1
29 craniodiaphyseal dysplasia 10.0 PLG SERPINE1
30 alcoholic gastritis 9.9 ADAM17 PLAT PLG
31 zika virus congenital syndrome 9.9 PLAT PLG SERPINE1
32 arcus senilis 9.9 PLG SERPINE1
33 coccidioidomycosis 9.9 PLAT PLG
34 budd-chiari syndrome 9.9 PLAT PLG SERPINE1
35 sydenham chorea 9.8 NPPB PLAT PLG SERPINE1
36 pregnancy loss, recurrent 1 9.8 PLAT PLG SERPINE1 SERPINF2
37 epstein-barr virus hepatitis 9.8 PLG SERPINF2
38 myocardial infarction 9.7 NPPB PLAT PLG SERPINE1 SERPINF2
39 chronic fatigue syndrome 8.8 CAMP NEXN NPPB PDZK1IP1 PIWIL2 PLAT
40 sezary's disease 8.4 ADAM17 CAMP NEXN NPPB PDZK1IP1 PIWIL2

Graphical network of the top 20 diseases related to Acute Pulmonary Heart Disease:



Diseases related to Acute Pulmonary Heart Disease

Symptoms & Phenotypes for Acute Pulmonary Heart Disease

MGI Mouse Phenotypes related to Acute Pulmonary Heart Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 ADAM17 NEXN PLAT PLG POR SERPINE1

Drugs & Therapeutics for Acute Pulmonary Heart Disease

Drugs for Acute Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 600)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
3
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 50-02-2 5743
5
Zinc Approved Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
6
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
7
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
8
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
9
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
10
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
11
Metformin Approved Phase 4 657-24-9 14219 4091
12
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
13
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
14
Rivaroxaban Approved Phase 4,Phase 3 366789-02-8
15
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
17
Dalteparin Approved Phase 4,Phase 3 9041-08-1
18
Nitroprusside Approved Phase 4,Phase 1 15078-28-1 11963622
19
Pioglitazone Approved, Investigational Phase 4,Early Phase 1 111025-46-8 4829
20
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
21
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
22
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
23
Montelukast Approved Phase 4,Phase 3 158966-92-8 5281040
24
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 54-31-9 3440
25
Morphine Approved, Investigational Phase 4 57-27-2 5288826
26
Spironolactone Approved Phase 4,Phase 2,Phase 3 1952-01-7, 52-01-7 5833
27
Diltiazem Approved Phase 4 42399-41-7 39186
28
Nitroglycerin Approved, Investigational Phase 4,Phase 3 55-63-0 4510
29
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
30
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
31
Iloprost Approved, Investigational Phase 4,Phase 2,Phase 1 78919-13-8 6443959
32
Bupropion Approved Phase 4,Phase 1,Phase 2 34841-39-9, 34911-55-2 444
33
Dobutamine Approved Phase 4,Phase 3,Phase 2,Phase 1 34368-04-2 36811
34
Ipratropium Approved Phase 4,Phase 2 22254-24-6, 60205-81-4 43232
35
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
36
Budesonide Approved Phase 4,Phase 1 51333-22-3 63006 5281004
37
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
38
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3 59-66-5 1986
39
Bupivacaine Approved, Investigational Phase 4,Phase 1 2180-92-9, 38396-39-3 2474
40
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
41
Propafenone Approved Phase 4,Phase 3 54063-53-5 4932
42
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
44
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 6447131 17753757
45
Ticagrelor Approved Phase 4,Phase 2 274693-27-5 9871419
46
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411
47
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
48
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
49
Insulin Lispro Approved Phase 4 133107-64-9
50
Fosfomycin Approved Phase 4 23155-02-4 446987

Interventional clinical trials:

(show top 50) (show all 1029)
id Name Status NCT ID Phase
1 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
2 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
3 Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism Unknown status NCT02132689 Phase 4
4 The Contact PVI Study: Use of Tissue Contact Data to Guide Atrial Fibrillation Ablation Unknown status NCT01629056 Phase 4
5 Incidence of Acute Cerebrovascular Events Using Either Minimized or Standard Cardiopulmonary Bypass Circuit Unknown status NCT00862160 Phase 4
6 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
7 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4
8 Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations Unknown status NCT01497691 Phase 4
9 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Unknown status NCT01660867 Phase 4
10 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4
11 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
12 Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease Completed NCT00181818 Phase 4
13 Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Completed NCT01060020 Phase 4
14 Non-Invasive Ventilation in Pulmonary Edema Completed NCT00453947 Phase 4
15 Lumbar Plexus Block Upon the Incidence of Ischemic Cardiovascular Events in Elderly Patients With Hip Fracture Completed NCT01961895 Phase 4
16 SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Completed NCT01046838 Phase 4
17 Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects Completed NCT03044938 Phase 4
18 Effect of Indacaterol Maleate in Chronic Obstructive Pulmonary Disease (COPD) on Lung Volume and Related Dyspnea Completed NCT01377051 Phase 4
19 Invasive vs Conservative Strategies in Non-ST-elevation Acute Coronary Syndrome and Comorbidities Completed NCT01645943 Phase 4
20 VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension Completed NCT01889966 Phase 4
21 Post-Market Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CF-EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation Completed NCT01196923 Phase 4
22 Durability of Pulmonary Vein Isolation Following Cryoablation for Treatment of Paroxysmal Atrial Fibrillation Completed NCT01645917 Phase 4
23 Ablation of the Pulmonary Veins for Paroxysmal Afib Completed NCT00744874 Phase 4
24 Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease Completed NCT02222246 Phase 4
25 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
26 Nitrate and Hypertension in Heart Transplanted Patients Completed NCT00449059 Phase 4
27 Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus Completed NCT02962921 Phase 4
28 Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement (HomeCARE II) Completed NCT00711360 Phase 4
29 Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement in Japan (J-HomeCARE II) Completed NCT01221649 Phase 4
30 Intraaortic Balloon Pump in Cardiogenic Shock II Completed NCT00491036 Phase 4
31 Epoprostenol in Pulmonary Embolism Completed NCT01014156 Phase 4
32 Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
33 Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation Completed NCT00453726 Phase 4
34 Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation Completed NCT00863213 Phase 4
35 Nordic Everolimus (Certican) Trial in Heart and Lung Transplantation Completed NCT00377962 Phase 4
36 Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude Completed NCT02024386 Phase 4
37 B-type Natriuretic Peptide for Acute Shortness of Breath EvaLuation (BASEL) Study - Private Practice Completed NCT00130611 Phase 4
38 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4
39 Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema Completed NCT00912158 Phase 4
40 B-type Natriuretic Peptide (BNP)-Guided Diagnostic Strategy in Intensive Care Unit (ICU) Patients With Respiratory Failure Completed NCT00130559 Phase 4
41 AZithromycin Against pLacebo in Exacerbations of Asthma Completed NCT01444469 Phase 4
42 The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass Completed NCT01435304 Phase 4
43 Rivaroxaban for the Prevention of Venous Thromboembolism in Asian Patients With Cancer Completed NCT01989845 Phase 4
44 Budesonide Inhalation Suspension for Acute Asthma in Children Completed NCT00393367 Phase 4
45 Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis Completed NCT01016249 Phase 4
46 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Recruiting NCT02416778 Phase 4
47 Comparison Between Contact Force Guided and Blinded Strategy on PV Isolation in AF Patients Recruiting NCT02924181 Phase 4
48 Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease Recruiting NCT02742909 Phase 4
49 Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea. Recruiting NCT02963597 Phase 4
50 Evaluation of Ablation Index and VISITAG™ (ABI-173) Recruiting NCT03062046 Phase 4

Search NIH Clinical Center for Acute Pulmonary Heart Disease

Genetic Tests for Acute Pulmonary Heart Disease

Anatomical Context for Acute Pulmonary Heart Disease

MalaCards organs/tissues related to Acute Pulmonary Heart Disease:

39
Heart

Publications for Acute Pulmonary Heart Disease

Variations for Acute Pulmonary Heart Disease

Expression for Acute Pulmonary Heart Disease

Search GEO for disease gene expression data for Acute Pulmonary Heart Disease.

Pathways for Acute Pulmonary Heart Disease

Pathways related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 ADAM17 PLAT PLG SERPINE1
2
Show member pathways
11.91 PLAT PLG SERPINE1
3
Show member pathways
11.76 PLAT PLG SERPINE1 SERPINF2
4 11.6 PLAT PLG SERPINE1 SERPINF2
5 11.59 PLG SERPINE1 VCL
6 11.28 PLAT PLG SERPINE1
7 10.55 ADAM17 PLAT PLG
8 10.04 PLAT PLG SERPINE1 SERPINF2

GO Terms for Acute Pulmonary Heart Disease

Cellular components related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CAMP NPPB PLAT PLG SERPINE1 SERPINF2
2 cell surface GO:0009986 9.56 ADAM17 PLAT PLG SERPINF2
3 extracellular space GO:0005615 9.43 CAMP NPPB PLAT PLG SERPINE1 SERPINF2
4 platelet alpha granule lumen GO:0031093 8.8 PLG SERPINE1 SERPINF2

Biological processes related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.46 PLG SERPINE1 SERPINF2 VCL
2 negative regulation of plasminogen activation GO:0010757 9.26 SERPINE1 SERPINF2
3 negative regulation of fibrinolysis GO:0051918 9.13 PLG SERPINE1 SERPINF2
4 fibrinolysis GO:0042730 8.92 PLAT PLG SERPINE1 SERPINF2

Molecular functions related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 8.92 NPPB PLAT PLG SERPINE1

Sources for Acute Pulmonary Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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