MCID: ACT080
MIFTS: 31

Acute Pulmonary Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Acute Pulmonary Heart Disease

MalaCards integrated aliases for Acute Pulmonary Heart Disease:

Name: Acute Pulmonary Heart Disease 12 14 69
Acute Pulmonary Heart Disease Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8514
ICD9CM 35 415
UMLS 69 C0155671

Summaries for Acute Pulmonary Heart Disease

MalaCards based summary : Acute Pulmonary Heart Disease, also known as acute pulmonary heart disease nos, is related to lin-gettig syndrome and dementia pugilistica. An important gene associated with Acute Pulmonary Heart Disease is EDEM1 (ER Degradation Enhancing Alpha-Mannosidase Like Protein 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes.

Related Diseases for Acute Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Acute Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 lin-gettig syndrome 10.7 PLAT PLG
2 dementia pugilistica 10.7 NPPB PLAT
3 pyridoxine deficiency anemia 10.7 PLG SERPINF2
4 bladder squamous papilloma 10.7 PLAT PLG
5 rectum neuroendocrine neoplasm 10.6 PLG SERPINF2
6 syndactyly, mesoaxial synostotic, with phalangeal reduction 10.6 PLG SERPINF2
7 blackwater fever 10.6 PLG SERPINF2
8 internal auditory canal meningioma 10.6 PLAT PLG
9 lymphatic system cancer 10.5 PLAT SERPINF2
10 generalized anxiety disorder 10.5 PLG SERPINE1
11 venezuelan hemorrhagic fever 10.5 PLAT SERPINE1
12 cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorinural hearing loss 10.5 PLAT SERPINE1
13 lujo hemorrhagic fever 10.5 PLG SERPINF2
14 lateral myocardial infarction 10.5 NPPB PLAT PLG
15 midline cystocele 10.5 PLG SERPINE1
16 coccidioidomycosis 10.5 PLAT PLG
17 otospondylomegaepiphyseal dysplasia 10.5 PLG SERPINE1
18 egg allergy 10.5 PLAT PLG SERPINF2
19 optic nerve neoplasm 10.4 PLAT SERPINE1
20 aryepiglottic fold cancer 10.4 ADAM17 PLAT PLG
21 monocytic leukemia 10.3 ADAM17 WDFY2
22 haemophilus meningitis 10.3 PLAT PLG SERPINE1
23 bone remodeling disease 10.3 PLAT PLG SERPINE1
24 split-hand/foot malformation 1 with sensorineural hearing loss 10.3 PLAT SERPINE1 SERPINF2
25 chronic diarrhea due to guanylate cyclase 2c overactivity 10.3 PLAT SERPINE1 SERPINF2
26 intestinal pseudo-obstruction 10.3 PLAT SERPINE1 SERPINF2
27 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.3 SERPINE1 VCL
28 arcus senilis 10.3 PLG SERPINE1
29 status asthmaticus 10.3 PLAT PLG
30 capillary hemangioma 10.2 ADAM17 PLG SERPINE1
31 monocular exotropia 10.2 PLAT SERPINE1
32 artery disease 10.2 NPPB PDZK1IP1
33 inherited blood coagulation disease 10.1 SERPINE1 SERPINF2
34 peripheral artery disease 10.1 NPPB PLAT PLG SERPINE1
35 thrombophilia due to activated protein c resistance 10.1 PLAT PLG SERPINE1 SERPINF2
36 brill-zinsser disease 10.1 PLAT PLG SERPINE1 SERPINF2
37 lubani-al saleh-teebi syndrome 10.1 NPPB PLAT PLG SERPINE1
38 meckel's diverticulum 10.0 NPPB PLAT SERPINE1 SERPINF2
39 adult respiratory distress syndrome 9.8 NPPB PLAT PLG SERPINE1 SERPINF2
40 myocardial infarction 9.8 NPPB PLAT PLG SERPINE1 SERPINF2
41 stroke, ischemic 9.6 PLAT PLG SERPINE1
42 hypopharynx cancer 5.7 CA2 CAMP CREB3L2 DESI2 EDEM1 NPPB
43 barbiturate abuse 4.8 ADAM17 CA2 CAMP CREB3L2 DESI2 EDEM1

Graphical network of the top 20 diseases related to Acute Pulmonary Heart Disease:



Diseases related to Acute Pulmonary Heart Disease

Symptoms & Phenotypes for Acute Pulmonary Heart Disease

Drugs & Therapeutics for Acute Pulmonary Heart Disease

Drugs for Acute Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 354)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4,Phase 3 9005-49-6
2
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
3
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
4
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
5
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
6
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
7
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
8
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
9
Nitroprusside Approved Phase 4,Phase 1 15078-28-1 11963622
10
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
11
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
12
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
16
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 2 55-63-0 4510
17
Insulin Lispro Approved Phase 4 133107-64-9
18
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
19
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411
20
Diltiazem Approved Phase 4 42399-41-7 39186
21
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
22
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177
23
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 6447131 17753757
24
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
25
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
26
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
27
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 2 54-31-9 3440
28
Dobutamine Approved Phase 4,Phase 3,Phase 1,Phase 2 34368-04-2 36811
29
Propafenone Approved Phase 4,Phase 3 54063-53-5 4932
30
Montelukast Approved Phase 4 158966-92-8 5281040
31
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
32
Ticlopidine Approved Phase 4,Phase 2 55142-85-3 5472
33
Spironolactone Approved Phase 4,Phase 2 1952-01-7, 52-01-7 5833
34
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
35
Milrinone Approved Phase 4 78415-72-2 4197
36
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
37
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
38
Colistin Approved Phase 4 1264-72-8, 1066-17-7 5311054
39
Fosfomycin Approved Phase 4 23155-02-4 446987
40
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
41
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
42
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
43
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
44 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
45
Clopidogrel Approved, Nutraceutical Phase 4,Phase 2 120202-66-6, 113665-84-2 60606
46
Lactitol Investigational Phase 4 585-86-4 3871
47
Maleic acid Experimental Phase 4 110-16-7 444266
48 Anticoagulants Phase 4,Phase 3,Phase 2
49 calcium heparin Phase 4,Phase 3
50 Fibrinolytic Agents Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 537)

id Name Status NCT ID Phase Drugs
1 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
2 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
3 Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism Unknown status NCT02132689 Phase 4 Actilyse (Thrombolytic therapy);Heparine (Standard anticoagulation therapy)
4 Incidence of Acute Cerebrovascular Events Using Either Minimized or Standard Cardiopulmonary Bypass Circuit Unknown status NCT00862160 Phase 4
5 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4 Indacaterol Fumarate;Placebo
6 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
7 Bupropion for Hospitalized Smokers With Acute Cardiovascular Disease Completed NCT00181818 Phase 4 bupropion SR (sustained-release)
8 Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Completed NCT01060020 Phase 4 Sildenafil
9 Non-Invasive Ventilation in Pulmonary Edema Completed NCT00453947 Phase 4
10 Lumbar Plexus Block Upon the Incidence of Ischemic Cardiovascular Events in Elderly Patients With Hip Fracture Completed NCT01961895 Phase 4 Intravenous patient-controlled analgesia
11 SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Completed NCT01046838 Phase 4 Sildenafil;Placebo
12 Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects Completed NCT03044938 Phase 4 salbutamol;Placebo
13 Effect of Indacaterol Maleate in Chronic Obstructive Pulmonary Disease (COPD) on Lung Volume and Related Dyspnea Completed NCT01377051 Phase 4 Indacaterol maleate;Placebo
14 Invasive vs Conservative Strategies in Non-ST-elevation Acute Coronary Syndrome and Comorbidities Completed NCT01645943 Phase 4
15 VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension Completed NCT01889966 Phase 4 Sildenafil
16 Post-Market Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CF-EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation Completed NCT01196923 Phase 4
17 Durability of Pulmonary Vein Isolation Following Cryoablation for Treatment of Paroxysmal Atrial Fibrillation Completed NCT01645917 Phase 4
18 Ablation of the Pulmonary Veins for Paroxysmal Afib Completed NCT00744874 Phase 4
19 Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease Completed NCT02222246 Phase 4 Hydromorphone (Standardized, weight-based dosing);Morphine Sulfate (Standardized, weight-based dosing);Hydromorphone (Patient Specific dosing);Morphine Sulfate (Patient Specific dosing)
20 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
21 Nitrate and Hypertension in Heart Transplanted Patients Completed NCT00449059 Phase 4 acute infusion of nitroglycerine into the pulmonary artery
22 Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus Completed NCT02962921 Phase 4 Insulin LISPRO intravenous loading
23 Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement (HomeCARE II) Completed NCT00711360 Phase 4
24 Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement in Japan (J-HomeCARE II) Completed NCT01221649 Phase 4
25 SMART China, A Multi-center Clinical Registry Study Completed NCT02485925 Phase 4
26 Intraaortic Balloon Pump in Cardiogenic Shock II Completed NCT00491036 Phase 4
27 Epoprostenol in Pulmonary Embolism Completed NCT01014156 Phase 4 epoprostenol
28 Acute Chest Pain Treatment and Evaluation (ACTION) Study Completed NCT00434564 Phase 4
29 Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation Completed NCT00453726 Phase 4
30 The Contact PVI Study: Use of Tissue Contact Data to Guide Atrial Fibrillation Ablation Completed NCT01629056 Phase 4
31 Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation Completed NCT00863213 Phase 4 Antiarrhythmic drug
32 Nordic Everolimus (Certican) Trial in Heart and Lung Transplantation Completed NCT00377962 Phase 4 Everolimus;Mycophenolic acid (MPA)/azathioprine (AZA);Calcineurin inhibitors (CNI);Steroids
33 Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude Completed NCT02024386 Phase 4 Riociguat
34 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Recruiting NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
35 Comparison Between Contact Force Guided and Blinded Strategy on PV Isolation in AF Patients Recruiting NCT02924181 Phase 4
36 Diuretic Vascular Filling in the Initial Management of Acute PE With Right Ventricular Dysfunction Normotensive Recruiting NCT02531581 Phase 4 Furosemide;NaCl 9% isotonic
37 Acute Effects of rhBNP in Patients With PH Associated With Acute Exacerbation of Chronic Pulmonary Disease Recruiting NCT02742909 Phase 4 rhBNP;placebo
38 Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea. Recruiting NCT02963597 Phase 4
39 Evaluation of Ablation Index and VISITAG™ (ABI-173) Recruiting NCT03062046 Phase 4
40 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4 4% albumin
41 Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude Recruiting NCT03173508 Phase 4 ACETAZOLAMIDE oral capsule;Placebo oral capsule
42 Milrinone Versus Dobutamine in Critically Ill Patients Recruiting NCT03207165 Phase 4 Milrinone;Dobutamine
43 Aztreonam for Inhalation Solution (AZLI) for the Treatment of Exacerbations of Cystic Fibrosis Recruiting NCT02894684 Phase 4 Aztreonam;Standard Care
44 Early Treatment of Atrial Fibrillation for Stroke Prevention Trial Active, not recruiting NCT01288352 Phase 4
45 Loop Diuretics Administration and Acute Heart Failure Active, not recruiting NCT01441245 Phase 4 furosemide infusion
46 Sleep Intervention During Acute Lung Injury Active, not recruiting NCT01050699 Phase 4 Dexmedetomidine;Midazolam and Fentanyl
47 MIdazolam Versus MOrphine in Acute Pulmonary Edema (MIMO Trial) Not yet recruiting NCT02856698 Phase 4 Midazolam;Morphine
48 Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure Reduced Ejection Fraction and Acute Decompensation With Low Cardiac Output (PRIORITY-ADHF Study) Not yet recruiting NCT02767024 Phase 4 Sodium nitroprusside;Dobutamine;Furosemide
49 Use of Nesiritide in the Management of Acute Diastolic Heart Failure Terminated NCT00083772 Phase 4 Nesiritide
50 Does Montelukast Have an Affect on the Function of the Artery in Patients With Heart Disease Terminated NCT00351364 Phase 4 Montelukast Sodium

Search NIH Clinical Center for Acute Pulmonary Heart Disease

Genetic Tests for Acute Pulmonary Heart Disease

Anatomical Context for Acute Pulmonary Heart Disease

MalaCards organs/tissues related to Acute Pulmonary Heart Disease:

39
Heart, Lung, Testes, Kidney, Bone, Bone Marrow, T Cells

Publications for Acute Pulmonary Heart Disease

Variations for Acute Pulmonary Heart Disease

Expression for Acute Pulmonary Heart Disease

Search GEO for disease gene expression data for Acute Pulmonary Heart Disease.

Pathways for Acute Pulmonary Heart Disease

GO Terms for Acute Pulmonary Heart Disease

Cellular components related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CA2 CAMP NPPB PLAT PLG SERPINE1
2 platelet alpha granule lumen GO:0031093 8.8 PLG SERPINE1 SERPINF2

Biological processes related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.46 PLG SERPINE1 SERPINF2 VCL
2 morphogenesis of an epithelium GO:0002009 9.32 CA2 VCL
3 negative regulation of plasminogen activation GO:0010757 9.26 SERPINE1 SERPINF2
4 negative regulation of fibrinolysis GO:0051918 9.13 PLG SERPINE1 SERPINF2
5 fibrinolysis GO:0042730 8.92 PLAT PLG SERPINE1 SERPINF2

Molecular functions related to Acute Pulmonary Heart Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.26 NPPB PLAT PLG SERPINE1
2 hydrolase activity GO:0016787 9.1 ADAM17 DESI2 EDEM1 PLAT PLG POR

Sources for Acute Pulmonary Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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