MCID: ACT042
MIFTS: 45

Acute Pyelonephritis malady

Categories: Nephrological diseases

Aliases & Classifications for Acute Pyelonephritis

Aliases & Descriptions for Acute Pyelonephritis:

Name: Acute Pyelonephritis 12 52 14 69
Acute Pyelonephritis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:559
ICD10 33 N10
ICD9CM 35 590.1
NCIt 47 C123215
UMLS 69 C0520575

Summaries for Acute Pyelonephritis

MalaCards based summary : Acute Pyelonephritis, also known as acute pyelonephritis nos, is related to pyelonephritis and coloboma of iris. An important gene associated with Acute Pyelonephritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Cefixime and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include kidney, neutrophil and testes, and related phenotypes are cardiovascular system and immune system

Related Diseases for Acute Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
id Related Disease Score Top Affiliating Genes
1 pyelonephritis 31.5 CRP CXCL8 IL10
2 coloboma of iris 10.3 CRP IL6
3 cutaneous sclerosis 10.3 CRP IL6
4 unilateral multicystic dysplastic kidney 10.3 CRP IL6
5 oculomotor nerve paralysis 10.3 CXCL8 IL6
6 common peroneal nerve lesion 10.3 CXCL8 IL6
7 sosby syndrome 10.3 CRP CXCL8
8 neutrophilia, hereditary 10.3 CRP IL6
9 swine influenza 10.3 CRP IL6
10 cardiac tuberculosis 10.3 CRP IL6
11 thymic neuroendocrine carcinoma 10.3 CXCL8 IL6
12 psychotic disorder 10.2 CXCL8 IL6
13 retinal vascular disease 10.2 CXCL8 IL6
14 ureter inverted papilloma 10.2 IL10 IL6
15 cicatricial lagophthalmos 10.2 CRP CXCL8 IL6
16 neuropathy 10.2 CRP CXCL8 IL6
17 cataract, total congenital 10.2 CRP IL6
18 schwannoma of ureter 10.2 CXCL8 CXCR1 IL6
19 limb ischemia 10.2 CRP CXCL8 IL6
20 inner ear disease 10.2 ALB IL6
21 diabetic encephalopathy 10.2 CRP CXCL8 IL6
22 neovascular glaucoma 10.2 CRP CXCL8 IL6
23 laryngotracheoesophageal cleft type 2 10.2 CRP IL6
24 conidiobolomycosis 10.2 CXCL8 IL10
25 synovium cancer 10.2 CRP CXCL8 IL6
26 inflammatory bowel disease 20 10.2 CXCL8 IL10
27 microglandular adenosis of breast 10.2 CXCL8 IL10
28 cataract 10.2 ALB CRP
29 coronary arterial fistulas 10.2 CXCL8 IL10
30 shoulder impingement syndrome 10.2 ALB CRP IL6
31 histiocytosis 10.2 CRP CXCL8 IL6
32 hidradenitis suppurativa 10.2 CXCL8 IL10
33 transient tic disorder 10.2 IL10 IL6
34 hyperlipoproteinemia type iv 10.1 ALB CRP IL6
35 ischemic optic neuropathy 10.1 ALB CRP IL6
36 gait apraxia 10.1 ALB CRP IL6
37 rift valley fever 10.1 ALB CRP IL6
38 capillary leak syndrome 10.1 ALB CRP CXCL8
39 cervix small cell carcinoma 10.1 ADM CRP IL6
40 central nervous system leiomyoma 10.1 ALB CRP IL6
41 spondyloarthropathy 2 10.1 ALB NAGLU
42 familial nephrotic syndrome 10.1 ALB CRP IL6
43 bacterial meningitis 10.1 ALB CRP IL6
44 labyrinthine bilateral reactive loss 10.1 ALB CXCL8 IL6
45 congenital chloride diarrhea 10.1 ALB CRP IL6
46 multiple mitochondrial dysfunctions syndrome 10.1 CRP IL10 IL6
47 chronic myocardial ischemia 10.1 ALB CRP IL6
48 follicular adenoma 10.1 CRP IL10 IL6
49 peroneal neuropathy 10.1 ALB CRP IL6
50 paranasal sinus sarcoma 10.1 ALB CXCL8 IL6

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to Acute Pyelonephritis

Symptoms & Phenotypes for Acute Pyelonephritis

MGI Mouse Phenotypes related to Acute Pyelonephritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ADM CRP CXCL10 CXCR2 IL10 IL6
2 immune system MP:0005387 9.81 ADM CRP CXCL10 CXCR1 CXCR2 IL10
3 liver/biliary system MP:0005370 9.43 ADM ALB CXCR2 IL10 IL6 NAGLU
4 neoplasm MP:0002006 9.02 ALB CXCR2 IL10 IL6 PGF

Drugs & Therapeutics for Acute Pyelonephritis

Drugs for Acute Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefixime Approved Phase 4 79350-37-1 54362 5362065
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
4
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
5
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
6
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
7
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
8
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
10
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 54575, 6560146 143
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2
14 Antitubercular Agents Phase 4,Phase 3
15 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
16 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
17 Fluoroquinolones Phase 4,Phase 2
18 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
19 Renal Agents Phase 4,Phase 3,Phase 2
20 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
21 Antimalarials Phase 4,Phase 3
22 Antiparasitic Agents Phase 4,Phase 3
23 Antiprotozoal Agents Phase 4,Phase 3
24 Folic Acid Antagonists Phase 4,Phase 3
25 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
26 Vitamin B Complex Phase 4,Phase 3
27 Lactams Phase 4
28 Folate Nutraceutical Phase 4,Phase 3
29 Vitamin B9 Nutraceutical Phase 4,Phase 3
30 Avibactam Approved Phase 3,Phase 2 1192500-31-4
31
Ceftazidime Approved Phase 3 78439-06-2 5481173
32
Meropenem Approved, Investigational Phase 3 119478-56-7 64778 441130
33
Piperacillin Approved Phase 3,Phase 2 66258-76-2 43672
34
Tazobactam Approved Phase 3,Phase 2 89786-04-9 123630
35
Colistin Approved Phase 3 1264-72-8, 1066-17-7 5311054
36
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
37
Tigecycline Approved Phase 3 220620-09-7 5282044
38
Fosfomycin Approved Phase 2, Phase 3 23155-02-4 446987
39
Ceftibuten Approved Phase 3 97519-39-6 5282241 5282242
40 Liver Extracts Phase 3
41 Avibactam, ceftazidime drug combination Phase 3
42 beta-Lactamase Inhibitors Phase 3,Phase 2
43 Thienamycins Phase 3
44 Penicillanic Acid Phase 3,Phase 2
45 Piperacillin, tazobactam drug combination Phase 3,Phase 2
46 Cephalosporins Phase 3,Phase 2
47 carnitine Nutraceutical Phase 3
48 Omega 3 Fatty Acid Nutraceutical Phase 3
49
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
50
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035

Interventional clinical trials:

(show all 47)
id Name Status NCT ID Phase
1 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4
2 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4
3 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4
4 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4
5 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4
6 Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication Completed NCT02246361 Phase 4
7 Study To Evaluate The Efficacy And Safety Of Ciprofloxacin Extended-Release (Cipro® XR) 1000 mg Tablets Given Once Daily For 7 To 14 Days In The Treatment Of Patients 18 Years Or Older With Complicated Urinary Tract Infections Caused By Pseudomonas Aerugi Completed NCT00481689 Phase 4
8 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Not yet recruiting NCT03179384 Phase 4
9 Safety and Efficacy Study of the Treatment of Kidney Infections With Short Course Levofloxacin Terminated NCT00239161 Phase 4
10 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3
11 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3
12 Contrast-Enhanced US of Spleen, Liver and Kidney Unknown status NCT00190281 Phase 3
13 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3
14 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3
15 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3
16 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3
17 Efficacy, Safety, Tolerability of Carbavance Compared to Piperacillin/Tazobactam in Complicated Urinary Tract Infections (cUTIs), Including Acute Pyelonephritis (AP), in Adults Completed NCT02166476 Phase 3
18 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3
19 Efficacy, Safety, Tolerability of Carbavance Compared to Best Available Therapy in Serious Infections Due to Carbapenem Resistant Enterobacteriaceae, in Adults Recruiting NCT02168946 Phase 3
20 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Active, not recruiting NCT02753946 Phase 2, Phase 3
21 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3
22 Study of Plazomicin (ACHN-490) Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis Completed NCT01096849 Phase 2
23 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2
24 Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Completed NCT01928433 Phase 2
25 Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections Completed NCT01281462 Phase 2
26 A Study of Efficacy/Safety of Intravenous S-649266 Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections Completed NCT02321800 Phase 2
27 Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Recruiting NCT02537847 Phase 2
28 Prospective Study in the Emergency Terminated NCT01628900 Phase 2
29 GSK2251052 in Complicated Urinary Tract Infection Terminated NCT01381549 Phase 2
30 Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection Unknown status NCT02034851
31 Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis Unknown status NCT00868270
32 Community-Associated Uropathogen Antimicrobial Resistance Among Emergency Department Patients With Acute Pyelonephritis Completed NCT01641029
33 Kinetics of Biomarkers in Acute Pyelonephritis Completed NCT00805181
34 Prospective Comparative Study About Treatment of Asymptomatic Bacteriuria in Kidney Transplant Recipients. Completed NCT02373085
35 Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae Completed NCT02420366
36 Epidemiology of Acute Bacterial Uncomplicated Cystitis in General Practice Completed NCT00958295
37 Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Children in the Paediatric A&E. Completed NCT01396798
38 Histology of Implantation Biopsies and Kidney Allograft Outcomes Completed NCT03155763
39 Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care Completed NCT02024282
40 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) Completed NCT01406275
41 Antibiotic Education for Children in an Emergency Care Unit Completed NCT00948779
42 Prognostic Indicators as Provided by the EPIC ClearView Completed NCT01476995
43 Proteinuria During Acute Pyelonephritis In Pregnancy Recruiting NCT02536638
44 Cranberry-lingonberry Juice Started During Acute Infection in Prevention of Urinary Tract Infections in Children Recruiting NCT01861353
45 Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli Terminated NCT01820793
46 Urell and Pregnancy Terminated NCT01818180
47 Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis Withdrawn NCT01137929

Search NIH Clinical Center for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

Anatomical Context for Acute Pyelonephritis

MalaCards organs/tissues related to Acute Pyelonephritis:

39
Kidney, Neutrophil, Testes, Liver, Colon, Prostate, Endothelial

Publications for Acute Pyelonephritis

Articles related to Acute Pyelonephritis:

(show top 50) (show all 592)
id Title Authors Year
1
Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )
2017
2
18F-FDG PET/CT in Renal Infections: Evidence of Acute Pyelonephritis in a Horseshoe Kidney. ( 27879491 )
2017
3
Eliciting renal tenderness by sonopalpation in diagnosing acute pyelonephritis. ( 28050884 )
2017
4
Multiple Renal Abscesses due to ESBL Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Causing Acute Pyelonephritis and Bacteremia: A Case Report with a Good Outcome (No Drainage Required). ( 28018690 )
2016
5
Are the unenhanced and excretory CT phases necessary for the evaluation of acute pyelonephritis? ( 27563103 )
2016
6
Acute pyelonephritis in transplanted kidneys: can diffusion-weighted magnetic resonance imaging be useful for diagnosis and follow-up? ( 27039324 )
2016
7
Acute pyelonephritis resulting in intense vascular blush during dynamic renal scintigraphy. ( 26917903 )
2016
8
Acute Pyelonephritis with Bacteremia Caused by Enterococcus hirae: A Rare Infection in Humans. ( 27127665 )
2016
9
Health care-associated acute pyelonephritis is associated with inappropriate empiric antibiotic therapy in the ED. ( 27130586 )
2016
10
Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population-Based Case-Control Study in Taiwan. ( 27539679 )
2016
11
Reverse kinetics of angiopoietin-2 and endotoxins in acute pyelonephritis: Implications for anti-inflammatory treatment? ( 26844659 )
2016
12
Diagnostic performance of initial serum lactate for predicting bacteremia in female patients with acute pyelonephritis. ( 27133532 )
2016
13
Renal tuberculosis presenting as acute pyelonephritis - A rarity. ( 27865246 )
2016
14
The gender specific risk factors for prolonged hospitalization due to acute pyelonephritis in a Japanese tertiary emergency center. ( 26712583 )
2016
15
Use of cefuroxime for women with community-onset acute pyelonephritis caused by cefuroxime-susceptible or -resistant Escherichia coli. ( 26767868 )
2016
16
Author's reply to the letter to the editor regarding "Hemoglobin level is a more predictive diagnostic marker for acute pyelonephritis than mean platelet volume". ( 27116249 )
2016
17
Usefulness of analytical parameters in the management of paediatric patients with suspicion of acute pyelonephritis. Is procalcitonin reliable? ( 27329559 )
2016
18
Ceftazidime-avibactam Versus Doripenem for the Treatment of Complicated Urinary Tract Infections, Including Acute Pyelonephritis: RECAPTURE, a Phase 3 Randomized Trial Program. ( 27313268 )
2016
19
Hemoglobin level is a more predictive diagnostic marker for acute pyelonephritis than mean platelet volume. ( 26868147 )
2016
20
AJKD Atlas of Renal Pathology: Acute Pyelonephritis. ( 27664480 )
2016
21
Outpatient treatment in women with acute pyelonephritis after visiting emergency department. ( 27534596 )
2016
22
Predictive Accuracy of Urinary neutrophil gelatinase associated lipocalin (NGAL) for renal parenchymal involvement in Children with Acute Pyelonephritis. ( 27053998 )
2016
23
Are first-generation cephalosporins obsolete? A retrospective, non-inferiority, cohort study comparing empirical therapy with cefazolin versus ceftriaxone for acute pyelonephritis in hospitalized patients. ( 26983859 )
2016
24
Exploiting the antivirulence efficacy of an ajoene-ciprofloxacin combination against Pseudomonas aeruginosa biofilm associated murine acute pyelonephritis. ( 26930141 )
2016
25
Association between Elevated Alanine Aminotransferase and Urosepsis in Children with Acute Pyelonephritis. ( 27066449 )
2016
26
Evaluation of the efficacy and tolerance of a short 7 day third-generation cephalosporin treatment in the management of acute pyelonephritis in young women in the emergency department. ( 26903277 )
2016
27
Plasma neutrophil gelatinase-associated lipocalin: a marker of acute pyelonephritis in children. ( 27744618 )
2016
28
Validity of Neutrophil Gelatinase Associated Lipocaline as a Biomarker for Diagnosis of Children with Acute Pyelonephritis. ( 27734430 )
2016
29
Acute focal bacterial nephritis in a cohort of hospitalized adult patients with acute pyelonephritis. Assessment of risk factors and a predictive model. ( 27986362 )
2016
30
Retrospective Comparison of Clinical Characteristics and In-Hospital Outcomes among Diabetic and Non-Diabetic Adults with Acute Pyelonephritis. ( 27891373 )
2016
31
Development of Epidural and Paraspinal Abscesses after Insufficient Evaluation and Treatment of Acute Pyelonephritis Caused by Staphylococcus aureus. ( 27688864 )
2016
32
A Case of Acute Pyelonephritis in Bilateral Renal Malrotation. ( 27689034 )
2016
33
Urachal abscess precipitated as acute pyelonephritis in an adult patient with diabetes. ( 26813570 )
2016
34
Acute pyelonephritis and renal vein thrombosis: A case report and review of the literature. ( 27234357 )
2016
35
Recurrent obstructive acute pyelonephritis: A rare form of Actinobaculum schaalii infection in a HIV-1 infected patient. ( 27940245 )
2016
36
The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection. ( 27564295 )
2016
37
Comparison of computed tomography findings between bacteremic and non-bacteremic acute pyelonephritis due to Escherichia coli. ( 27158427 )
2016
38
Adult Idiopathic Renal Vein Thrombosis Mimicking Acute Pyelonephritis. ( 27790518 )
2016
39
Core curriculum illustration: acute pyelonephritis. ( 28032258 )
2016
40
Impact of Extended-Spectrum I^-Lactamase Production on Treatment Outcomes of Acute Pyelonephritis Caused by Escherichia coli in Patients without Health Care-Associated Risk Factors. ( 25583722 )
2015
41
Vitamin e as adjuvant treatment for urinary tract infection in girls with acute pyelonephritis. ( 25851287 )
2015
42
Effect of N-Acetylcysteine on Inflammation Biomarkers in Pediatric Acute Pyelonephritis: a Randomized Controlled Trial. ( 26552352 )
2015
43
The evidence for treating acute pyelonephritis with oral antibiotic therapy and short intravenous treatment is growing for low-risk children. ( 25736044 )
2015
44
Megalocytic interstitial nephritis following acute pyelonephritis with Escherichia coli bacteremia: a case report. ( 25552891 )
2015
45
A comparison of the clinical characteristics of elderly and non-elderly women with community-onset, non-obstructive acute pyelonephritis. ( 25995668 )
2015
46
Erratum: Intrathoracic kidney with left-sided Bochdalek hernia in a woman with bacteremic acute pyelonephritis due to Escherichia coli. ( 25995678 )
2015
47
Differentiation of acute pyelonephritis from other febrile states in children using urinary neutrophil gelatinase-associated lipocalin (uNGAL). ( 26053013 )
2015
48
Urinary neutrophil gelatinase-associated lipocalin (NGAL) might be an independent marker for anticipating scar formation in children with acute pyelonephritis. ( 26060836 )
2015
49
Intrathoracic kidney with left-sided Bochdalek hernia in a woman with bacteremic acute pyelonephritis due to Escherichia coli. ( 25750574 )
2015
50
Propensity-Matched Analysis To Compare the Therapeutic Efficacies of Cefuroxime versus Cefotaxime as Initial Antimicrobial Therapy for Community-Onset Complicated Nonobstructive Acute Pyelonephritis Due to Enterobacteriaceae Infection in Women. ( 25645837 )
2015

Variations for Acute Pyelonephritis

Expression for Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for Acute Pyelonephritis

Pathways related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
2
Show member pathways
12.76 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
3
Show member pathways
11.94 CXCL10 CXCL8 IL6
4 11.92 CXCL8 IL10 IL6
5
Show member pathways
11.91 CXCL8 IL10 IL6
6 11.77 CXCL10 CXCL8 IL6
7 11.73 CXCL8 IL10 IL6
8
Show member pathways
11.65 CXCL10 CXCL8 CXCR1 CXCR2
9 11.64 CXCL8 IL10 IL6
10 11.51 CXCL8 IL10 IL6
11 11.32 CXCL8 CXCR1 IL6
12 11.27 CXCL8 IL10 IL6
13 11.03 IL10 IL6
14 10.9 CXCL10 CXCL8 IL10 IL6
15 10.61 CXCL10 CXCL8 IL10 IL6
16 10.41 CRP CXCL8 IL6

GO Terms for Acute Pyelonephritis

Cellular components related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ADM ALB CRP CXCL10 CXCL8 IL10
2 extracellular space GO:0005615 9.23 ADM ALB CRP CXCL10 CXCL8 IL10

Biological processes related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CXCL10 CXCL8 IL10 IL6
2 negative regulation of cell proliferation GO:0008285 9.91 ADM CXCL8 IL10 IL6
3 cell-cell signaling GO:0007267 9.86 ADM CXCL10 IL10 PGF
4 positive regulation of cell proliferation GO:0008284 9.85 ADM CXCL10 CXCR2 IL6 PGF
5 aging GO:0007568 9.8 ADM IL10 IL6
6 positive regulation of angiogenesis GO:0045766 9.76 ADM CXCL8 PGF
7 response to lipopolysaccharide GO:0032496 9.73 ADM CXCL10 IL10 IL6
8 response to glucocorticoid GO:0051384 9.69 ADM IL10 IL6
9 defense response to Gram-positive bacterium GO:0050830 9.67 ADM CRP IL6
10 chemotaxis GO:0006935 9.67 CXCL10 CXCL8 CXCR1 CXCR2
11 response to insulin GO:0032868 9.65 ADM IL10 IL6
12 defense response to protozoan GO:0042832 9.62 IL10 IL6
13 dendritic cell chemotaxis GO:0002407 9.61 CXCR1 CXCR2
14 cellular response to hepatocyte growth factor stimulus GO:0035729 9.6 IL10 IL6
15 induction of positive chemotaxis GO:0050930 9.59 CXCL8 PGF
16 response to molecule of bacterial origin GO:0002237 9.58 CXCL8 IL10
17 response to cold GO:0009409 9.58 ADM CXCL10 IL6
18 response to auditory stimulus GO:0010996 9.57 CXCL10 IL6
19 cellular response to lipopolysaccharide GO:0071222 9.56 CXCL10 CXCL8 IL10 IL6
20 negative regulation of lipid storage GO:0010888 9.55 CRP IL6
21 branching involved in labyrinthine layer morphogenesis GO:0060670 9.54 ADM IL10
22 neutrophil activation GO:0042119 9.52 CXCL8 CXCR2
23 chemokine-mediated signaling pathway GO:0070098 9.46 CXCL10 CXCL8 CXCR1 CXCR2
24 interleukin-8-mediated signaling pathway GO:0038112 9.32 CXCR1 CXCR2
25 receptor internalization GO:0031623 9.26 ADM CXCL8 CXCR1 CXCR2
26 inflammatory response GO:0006954 9.17 CRP CXCL10 CXCL8 CXCR1 CXCR2 IL10

Molecular functions related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 IL10 IL6 PGF
2 cytokine activity GO:0005125 9.46 CXCL10 CXCL8 IL10 IL6
3 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
4 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
5 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Acute Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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