MCID: ACT042
MIFTS: 49

Acute Pyelonephritis malady

Summaries for Acute Pyelonephritis

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Acute Pyelonephritis, also known as acute pyelonephritis nos, is related to vesicoureteral reflux and bacteriuria. An important gene associated with Acute Pyelonephritis is CXCR1 (chemokine (C-X-C motif) receptor 1), and among its related pathways are Cell adhesion ECM remodeling and Spinal Cord Injury. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and kidney, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Acute Pyelonephritis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT
See all sources

Aliases & Descriptions:

acute pyelonephritis 8 45 61
acute pyelonephritis nos 8


External Ids:

Disease Ontology8 DOID:559
ICD9CM27 590.1

Related Diseases for Acute Pyelonephritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the pyelonephritis family:

acute pyelonephritis chronic pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1vesicoureteral reflux30.7NAGLU
2bacteriuria30.6CRP
3bacteremia30.5MBL2, CRP
4septic shock30.4CRP, POMC, MIF, IL1R1, IL8, ADM
5sepsis30.4MBL2, CRP, MIF, NAMPT, CXCR2, CXCR1
6hydronephrosis30.2NAGLU
7arthritis30.2TIMP1, CRP, POMC, MIF, CXCR2, CXCR1
8nephritis30.0IL1R1
9thrombocytopenia30.0GOT1, IL7, IL1R1
10kawasaki disease30.0TIMP1, MBL2, CRP, ADM
11acute cystitis10.4
12adult respiratory distress syndrome10.2
13adult syndrome10.2
14adult acute respiratory distress syndrome10.2
15anuria10.0
16epidural abscess10.0
17pseudohypoaldosteronism10.0
18subacute glomerulonephritis10.0
19renal glycosuria10.0
20nephrolithiasis10.0
21carbuncle10.0
22hyperhomocysteinemia10.0
23ureterocele10.0
24septic arthritis10.0
25acute cholangitis10.0
26shwartzman phenomenon10.0
27phaeochromocytoma10.0
28urinary tract obstruction10.0
29horseshoe kidney10.0
30klebsiella10.0
31mannose-binding lectin deficiency10.0
32spinal cord injury10.0
33peritonitis10.0CRP
34coronary heart disease10.0CRP
35aortic aneurysm10.0CRP
36crohn's disease10.0CRP
37familial mediterranean fever10.0CRP
38rheumatic disease10.0CRP
39dermatitis10.0CXCL10
40psoriatic arthritis10.0CRP
41osteomyelitis10.0CRP
42ankylosing spondylitis10.0CRP
43malaria10.0MIF
44tonsillitis10.0CRP
45cystitis10.0NAGLU
46severe acute respiratory syndrome10.0CXCL10
47respiratory failure10.0CRP
48graves' disease10.0CXCL10
49gallbladder disease10.0GOT1
50bronchiolitis10.0IL8

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to acute pyelonephritis

Clinical Features for Acute Pyelonephritis

Drugs & Therapeutics for Acute Pyelonephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Acute Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Acute Pyelonephritis

Search NIH Clinical Center for Acute Pyelonephritis

Search CenterWatch for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

Anatomical Context for Acute Pyelonephritis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acute Pyelonephritis:

33
Liver, Spinal cord, Kidney, Whole blood, Cortex, Colon, Thyroid, Prostate, B cells

Animal Models for Acute Pyelonephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acute Pyelonephritis

Sources:
51PubMed
See all sources

Articles related to Acute Pyelonephritis:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Inflammatory pre-conditioning of mesenchymal multipotent stromal cells improves their immunomodulatory potency in acute pyelonephritis in rats. (23562307)
2013
2
Systematic kidney biopsies after acute allograft pyelonephritis. (23530925)
2013
3
Clinical value of acute pyelonephritis grade based on computed tomography in predicting severity and course of acute pyelonephritis. (23674018)
2013
4
Soluble TRAIL in normal pregnancy and acute pyelonephritis: a potential explanation for the susceptibility of pregnant women to microbial products and infection. (23480056)
2013
5
Enterococcus hirae-related acute pyelonephritis and cholangitis with bacteremia: an unusual infection in humans. (22313539)
2012
6
Acute antepartum pyelonephritis in pregnancy: a critical analysis of risk factors and outcomes. (22381037)
2012
7
Efficacy and safety of ceftazidime-avibactam versus imipenem-cilastatin in the treatment of complicated urinary tract infections, including acute pyelonephritis, in hospitalized adults: results of a prospective, investigator-blinded, randomized study. (23145859)
2012
8
Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: host-pathogen interaction in urinary tract infections. (22327887)
2012
9
Ciprofloxacin for 7 days versus 14 days in women with acute pyelonephritis: a randomised, open-label and double-blind, placebo-controlled, non-inferiority trial. (22726802)
2012
10
Histopathologic detection of rejection in acute allograft pyelonephritis. (23038631)
2012
11
Serious acute pyelonephritis: a predictive score for evaluation of deterioration of treatment based on clinical and radiologic findings using CT. (22185707)
2012
12
Diagnosis and treatment of acute pyelonephritis in women. (21888302)
2011
13
The role of procalcitonin for acute pyelonephritis and subsequent renal scarring in infants and young children. (21944121)
2011
14
Doppler ultrasonography as a predictive tool for permanent kidney damage following acute pyelonephritis: comparison with dimercaptosuccinic acid scintigraphy. (22057070)
2011
15
International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. (21292654)
2011
16
Maternal plasma concentration of the pro-inflammatory adipokine pre-B-cell-enhancing factor (PBEF)/visfatin is elevated in pregnant patients with acute pyelonephritis. (20085562)
2010
17
Acute bacterial pyelonephritis resulting in acute kidney failure: a complication of chronic non-steroidal anti-inflammatory drug use? (19335847)
2009
18
Relationship between serum and urine interleukin-6 elevations and renal scarring in children with acute pyelonephritis. (18972261)
2009
19
Acute pyelonephritis caused by Aerococcus urinae in a 12-year-old boy. (18574434)
2008
20
Short- versus long-course antibiotic therapy for acute pyelonephritis in adolescents and adults: a meta-analysis of randomized controlled trials. (19014841)
2008
21
Prospective, randomized trial comparing short and long intravenous antibiotic treatment of acute pyelonephritis in children: dimercaptosuccinic acid scintigraphic evaluation at 9 months. (18267977)
2008
22
Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. (17763275)
2007
23
Initial presentation of scintigraphic changes during the first episode of acute pyelonephritis in children: simultaneous evaluation with MAG3 and DMSA. (17690790)
2007
24
Acute retroperitoneal hemorrhage complicating a xanthogranulomatous pyelonephritis. (16855836)
2007
25
Comparison of MRI and renal cortical scintigraphy findings in childhood acute pyelonephritis: preliminary experience. (14975495)
2004
26
Hyponatremia and hyperkalemia in infants with acute pyelonephritis. (14745637)
2004
27
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in acute pyelonephritis and renal scarring. (12612199)
2003
28
Color and power Doppler sonography versus DMSA scintigraphy in acute pyelonephritis and in prediction of renal scarring. (11801699)
2002
29
Acute lumbago and sciatica as first symptoms of focal xanthogranulomatous pyelonephritis. (12372898)
2002
30
Procalcitonin in pyelonephritis and acute community-acquired pneumonia in adults]. (11484399)
2001
31
Follow-up of acute pyelonephritis in children by Tc-99m DMSA scintigraphy: quantitative and qualitative assessment. (11317023)
2001
32
Attitude of Belgian pediatricians toward strategy in acute pyelonephritis. (11261676)
2001
33
Early biliary pseudolithiasis during ceftriaxone therapy for acute pyelonephritis in children: a prospective study in 34 children. (11215777)
2000
34
Intravenous urography revisited in the age of ultrasound and computerized tomography: diagnostic yield in cases of renal colic, suspected pelvic and abdominal malignancies, suspected renal mass, and acute pyelonephritis. (9253122)
1997
35
Fever in the clinical diagnosis of acute pyelonephritis. (9115515)
1997
36
Interleukin-1 alpha and interleukin-1 receptor antagonist in the urine of children with acute pyelonephritis and relation to renal scarring. (8640042)
1996
37
Power Doppler sonographic pattern of acute pyelonephritis in children: comparison with CT. (8633462)
1996
38
Survey of the attitudes to management of acute pyelonephritis in children. GEP. (7917849)
1994
39
Renal scarring after acute pyelonephritis. (8129430)
1994
40
Rational use of CT in acute pyelonephritis: findings and relationships with reflux. (8414754)
1993
41
Acute pyelonephritis. Preventing complications through prompt diagnosis and proper therapy. (1738745)
1992
42
Relationship among vesicoureteral reflux, P-fimbriated Escherichia coli, and acute pyelonephritis in children with febrile urinary tract infection. (1681043)
1991
43
Fecal colonization with P-fimbriated Escherichia coli as a predictor of acute pyelonephritis in infancy--a prospective study. (2905694)
1988
44
Acute pyelonephritis associated with bacteriuria during long-term catheterization: a prospective clinicopathological study. (3198942)
1988
45
Adult respiratory distress syndrome as a complication of acute pyelonephritis during pregnancy: case report and discussion. (3945462)
1986
46
The ultrastructure of acute pyelonephritis in the monkey. (6427482)
1984
47
Clinical studies in acute pyelonephritis: is there a place for renal quantitative camera study? (7120544)
1982
48
Occurrence of mycoplasmas in urinary tracts of patients with acute pyelonephritis. (670389)
1978
49
An ultrastructural study of the renal medulla in experimental acute pyelonephritis. (1099824)
1975
50
Clinico-pathological conference: hypoplasia of the kidneys secondary to chronic pyelonephritis; acute bronchitis; myocardial hypertrophy; fatty metamorphosis of the liver; rickets. (14870327)
1951

Genetic Variations for Acute Pyelonephritis

Expression for genes affiliated with Acute Pyelonephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for genes affiliated with Acute Pyelonephritis

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 54Reactome
See all sources

Compounds for genes affiliated with Acute Pyelonephritis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7CXCL10
2estrogen4510.6MBL2
3pge24510.5AQP2, POMC
4endotoxin4510.5CXCR2, ADM
5norepinephrine45 11 2412.4POMC, ADM
6rantes4510.2IL7, IL1R1, MBL2, CXCR1
7hydrocortisone45 2 60 1113.2AQP2, POMC, IL8, ADM
8h2o24510.1MIF, IL1R1, NAGLU
9grogamma4510.1IL8, CXCR1, CXCR2
10groalpha4510.0IL8, CXCR2, CXCR1, CXCL10
11superoxide45 2411.0CXCR2, MBL2
12homocysteine45 2411.0MIF, CRP, ADM, IL1R1, NAGLU
13etanercept45 50 1112.0IL8, CRP, TIMP1, IL1R1
14cyclosporin a45 29 6012.0IL1R1, NAGLU, AQP2, ADM, TNFRSF8
15grobeta4510.0IL8, CXCR1, CXCR2
16il 10459.9CXCL10, IL7, IL8, IL1R1
17infliximab45 50 1111.9CRP, IL1R1, TIMP1, CXCL10
18lipoteichoic acid459.9CXCR2, IL8, MBL2, IL1R1
19gold sodium thiomalate459.9NAGLU, IL8, IL1R1
20glucose459.9NAGLU, AQP2, ADM, NAMPT, POMC, FBP1
21ccl345 2910.9CXCR1, CXCL10, IL1R1, IL8
22neopterin459.8IL8, CXCL10, NAGLU, CRP, MBL2, IL1R1
23cyclophosphamide45 50 1111.8MBL2, IL1R1, NAGLU, MIF, IL7, CRP
24ccl445 2910.7TIMP1, CXCL10, IL1R1, IL7
25creatinine459.7CXCL10, NAGLU, NAMPT, AQP2, POMC, CRP
26oxygen45 2410.7CXCR1, CXCR2, IL8, MBL2, ADM, NAGLU
27tuberculin459.7MIF, TNFRSF8, MBL2
28losartan45 50 29 1112.7UGT1A1, CRP, ADM
29herbimycin a45 6010.7MIF, IL8, CXCR1, CXCR2, TIMP1
30leukotriene b445 60 2411.7CXCR1, IL8, IL7, IL1R1, CXCL10, CXCR2
31fibrinogen459.6IL1R1, IL7, NAMPT, MBL2, CRP, CXCR2
32lactate459.5TIMP1, CRP, MIF, NAGLU, IL1R1, IL8
33heparin45 29 11 2412.5IL1R1, IL8, IL7, CXCR2, TIMP1, NAGLU
34dexamethasone45 50 29 1112.4CXCR1, IL1R1, AQP2, NAMPT, POMC, UGT1A1
35paraffin459.3ADM, MIF, TIMP1, TNFRSF8, POMC, MBL2
36thymidine45 2410.3ADM, IL7, TNFRSF8, NAGLU, UGT1A1, IL1R1
37serine459.3TIMP1, IL8, IL1R1, MIF, CXCR2, POMC
38phosphatidylinositol459.3TIMP1, NAMPT, ADM, CXCR2, CXCR1, CXCL10
39genistein45 29 60 2 11 2414.3TIMP1, UGT1A1, MIF, CXCR2, CXCL10, IL7
40steroid459.2AQP2, MBL2, UGT1A1, ADM, IL7, POMC
41progesterone45 60 29 11 2413.1MBL2, POMC, ADM, TIMP1, UGT1A1, CXCL10
42cholesterol45 29 11 2412.1ADM, IL7, TIMP1, NAMPT, MBL2, UGT1A1
43retinoic acid45 249.9MIF, TIMP1, UGT1A1, ADM, LGALS7, IL7
44cysteine458.8ADM, TIMP1, NAGLU, MBL2, MIF, AQP2
45nitric oxide45 11 2410.8MIF, MBL2, TIMP1, ADM, CXCR2, IL1R1
46alanine458.6AQP2, TIMP1, IL7, CRP, POMC, NAGLU
47calcium45 50 11 2411.6MIF, TNFRSF8, MBL2, NAGLU, CXCR1, CXCL10
48tyrosine458.6CXCL10, ADM, IL1R1, TIMP1, TNFRSF8, IL7
49vegf458.6IL8, ADM, POMC, CRP, CXCR2, IL7
50lipid458.5AQP2, IL1R1, CXCL10, NAGLU, CXCR1, CXCR2

GO Terms for genes affiliated with Acute Pyelonephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9CRP, POMC, MIF, CXCL10, IL7, IL8
2extracellular regionGO:0055768.2ADM, TIMP1, MBL2, CRP, POMC, MIF

Biological processes related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.3CXCR1, CXCR2
2response to starvationGO:04259410.1AQP2, ADM, UGT1A1
3dendritic cell chemotaxisGO:00240710.1CXCR1, CXCR2
4opsonizationGO:00822810.0MBL2, CRP
5agingGO:00756810.0AQP2, ADM, CRP, TIMP1
6receptor internalizationGO:03162310.0ADM, IL8, CXCR1, CXCR2
7response to lipopolysaccharideGO:03249610.0UGT1A1, CXCL10, ADM, AQP2
8acute-phase responseGO:00695310.0CRP, UGT1A1, MBL2
9cell surface receptor signaling pathwayGO:0071669.8MIF, CXCR2, CXCR1, CXCL10, IL1R1
10cell-cell signalingGO:0072679.7POMC, NAMPT, CXCL10, IL7, ADM
11neutrophil activationGO:0421199.7IL8, CXCR2
12inflammatory responseGO:0069549.6CRP, MIF, CXCR2, CXCR1, CXCL10, IL8
13positive regulation of cell proliferationGO:0082849.5TIMP1, NAMPT, CXCR2, CXCL10, IL7, ADM
14signal transductionGO:0071659.0TNFRSF8, POMC, NAMPT, CXCR2, CXCL10, IL8

Molecular functions related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-8 bindingGO:01995910.1CXCR1, CXCR2
2interleukin-8 receptor activityGO:0049189.8CXCR1, CXCR2
3receptor bindingGO:0051029.4ADM, CXCL10, MIF, POMC, MBL2

Products for genes affiliated with Acute Pyelonephritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Pyelonephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet