MCID: ACT042
MIFTS: 52

Acute Pyelonephritis malady

Summaries for Acute Pyelonephritis

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32MalaCards
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MalaCards: Acute Pyelonephritis, also known as acute pyelonephritis nos, is related to pyelonephritis and vesicoureteral reflux. An important gene associated with Acute Pyelonephritis is CXCR1 (chemokine (C-X-C motif) receptor 1), and among its related pathways are Cell adhesion ECM remodeling and Spinal Cord Injury. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and testes, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Acute Pyelonephritis

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

acute pyelonephritis 8 44 60
acute pyelonephritis nos 8


External Ids:

Disease Ontology8 DOID:559
ICD9CM27 590.1

Related Diseases for Acute Pyelonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Pyelonephritis family:

acute pyelonephritis Chronic Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis32.0CRP, NAGLU, CXCR1
2vesicoureteral reflux30.7NAGLU
3bacteriuria30.6CRP
4cystitis30.6NAGLU
5osteomyelitis30.2CRP
6hydronephrosis30.2NAGLU
7arthritis30.2TIMP1, CRP, POMC, MIF, CXCR2, CXCR1
8hepatitis29.9UGT1A1, CXCL10
9thyroiditis29.9POMC, MBL2
10thrombocytopenia29.9GOT1, IL7, IL1R1
11glomerulonephritis29.9IL1R1, NAGLU, MIF, MBL2
12kawasaki disease29.9TIMP1, MBL2, CRP, ADM
13influenza29.9LGALS7, IL7, CXCL10, MBL2
14diabetes mellitus29.9GOT1, IL1R1, NAMPT, NAGLU, POMC, FBP1
15pneumonia29.9MBL2, CRP, NAGLU, CXCR2, CXCL10, IL8
16rheumatoid arthritis29.9TNFRSF8, MBL2, TIMP1, CRP, MIF, NAGLU
17acute cystitis10.4
18chronic pyelonephritis10.2
19adult respiratory distress syndrome10.1
20adult syndrome10.1
21prostatitis10.1
22peritonitis10.0CRP
23coronary heart disease10.0CRP
24aortic aneurysm10.0CRP
25crohn's disease10.0CRP
26familial mediterranean fever10.0CRP
27rheumatic disease10.0CRP
28acute thyroiditis10.0
29anuria10.0
30perinephritis10.0
31epidural abscess10.0
32pseudohypoaldosteronism10.0
33subacute glomerulonephritis10.0
34renal glycosuria10.0
35nephrolithiasis10.0
36carbuncle10.0
37hyperhomocysteinemia10.0
38ureterocele10.0
39septic arthritis10.0
40acute cholangitis10.0
41shwartzman phenomenon10.0
42phaeochromocytoma10.0
43acute cervicitis10.0
44candidiasis10.0
45cervicitis10.0
46cholangitis10.0
47interstitial nephritis10.0
48leiomyoma10.0
49ovarian cyst10.0
50pyelitis10.0

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to acute pyelonephritis

Clinical Features for Acute Pyelonephritis

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Drugs & Therapeutics for Acute Pyelonephritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Acute Pyelonephritis

Search NIH Clinical Center for Acute Pyelonephritis

Search CenterWatch for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

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Anatomical Context for Acute Pyelonephritis

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32MalaCards
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MalaCards organs/tissues related to Acute Pyelonephritis:

32
Kidney, Liver, Testes, Prostate, Colon, Thyroid, Whole blood, Spinal cord, Cortex, B cells

Animal Models for Acute Pyelonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0POMC, NAGLU, CXCR2, IL1R1, ADM, AQP2
2MP:00053858.9CRP, POMC, NAGLU, CXCR2, CXCL10, IL1R1
3MP:00053768.3TIMP1, MBL2, CRP, POMC, MIF, NAMPT
4MP:00053977.8MIF, POMC, TNFRSF8, MBL2, TIMP1, NAGLU
5MP:00053877.7ADM, TIMP1, MBL2, TNFRSF8, CRP, POMC

Publications for Acute Pyelonephritis

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50PubMed
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Articles related to Acute Pyelonephritis:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Diagnostic usefulness of procalcitonin as a marker of bacteremia in patients with acute pyelonephritis. (23772894)
2013
2
Acute abdominal pain in a 24-year-old woman: Fitz-Hugh-Curtis syndrome associated with pyelonephritis. (23295607)
2012
3
Severe hypercalcemia in nonobstructive pyelonephritis with acute renal failure: hit or miss? (22100475)
2012
4
Clinical significance of periportal tracking as an extrarenal manifestation of acute pyelonephritis. (21125400)
2011
5
Pyelonephritis (acute) in non-pregnant women. (21477395)
2011
6
Unilateral acute pyelonephritis associated with a neglected pessary. (22091509)
2011
7
Technetium Tc 99m dimercaptosuccinic acid renal scintigraphy in children with acute pyelonephritis: correlation with other imaging tests. (20852370)
2010
8
Prospective cohort study of acute pyelonephritis in adults: safety of triage towards home based oral antimicrobial treatment. (19945482)
2010
9
Urine macrophage migration inhibitory factor (MIF) in children with urinary tract infection: a possible predictor of acute pyelonephritis. (18800229)
2009
10
The effects of an institutional care map on the admission rates and medical costs in women with acute pyelonephritis. (18370984)
2008
11
Urinary N-acetyl-beta-D-glucosaminidase as a diagnostic marker of acute pyelonephritis in children. (19367005)
2008
12
Antibiotics for acute pyelonephritis in children. (17943796)
2007
13
Resolution of cortical lesions on serial renal scans in children with acute pyelonephritis. (17171352)
2007
14
Acute pyelonephritis: management steps that remain unresolved. (17918100)
2007
15
Accurate diagnosis of acute pyelonephritis: How helpful is procalcitonin? (16894326)
2006
16
Extrarenal manifestations of severe acute pyelonephritis: CT findings in 21 cases. (16941112)
2006
17
Inferior vena cava thrombosis due to acute pyelonephritis. (15031360)
2004
18
Quantitative analysis of 99mTc-DMSA during acute pyelonephritis for prediction of long-term renal scarring. (14960649)
2004
19
Cytokines and cell adhesion molecules in the inflammatory response during acute pyelonephritis. (14752242)
2004
20
Matrix metalloprotenase-9 in acute pyelonephritis. (14763447)
2004
21
Pediatric acute pyelonephritis: diagnosis facilitated by skeletal scintigraphy. (14508285)
2003
22
Power Doppler sonography versus Tc-99m DMSA scintigraphy for diagnosing acute pyelonephritis in children: are these two methods comparable? (12592126)
2003
23
Age-related radiological imaging in children with acute pyelonephritis. (11793131)
2002
24
The management of acute pyelonephritis in adults. (11442995)
2001
25
Hepatic periportal tracking associated with severe acute pyelonephritis. (10823444)
2000
26
Imaging in acute pyelonephritis. American College of Radiology. ACR Appropriateness Criteria. (11037483)
2000
27
Relevance in the emergency department of a decisional algorithm for outpatient care of women with acute pyelonephritis. (10340729)
1999
28
Unexpected diagnosis of acute pyelonephritis as a cause in neonatal osteomyelitis and septic arthritis using Ga-67 citrate scintigraphy (10512116)
1999
29
Combined use of urinary alpha1-microglobulin and 99mTc DMSA scintigraphy in the diagnosis and follow-up of acute pyelonephritis and cystitis in children. (9831790)
1998
30
Aminoglycosides do not improve the efficacy of cephalosporins for treatment of acute pyelonephritis in women. (9181655)
1997
31
Acute pyelonephritis in a child caused by Proteus penneri. (9227829)
1997
32
Acute renal failure due to acute pyelonephritis. (7591568)
1995
33
Renal cortical scintigraphy in the diagnosis of acute pyelonephritis. (1317065)
1992
34
Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. (1651644)
1991
35
Attenuation of antibody response to acute pyelonephritis by treatment with antibiotics. (1804007)
1991
36
Acute pyelonephritis in pregnancy: a prospective study of oral versus intravenous antibiotic therapy. (2216244)
1990
37
Renal imaging with 99Tcm-labelled DMSA in the detection of acute pyelonephritis: an experimental study in the pig. (2537481)
1989
38
Urographic renal size in acute pyelonephritis in childhood. (2965897)
1988
39
Efficacy and safety of once daily versus intermittent dosing of tobramycin in rabbits with acute pyelonephritis. (2899906)
1988
40
Fosfomycin versus ampicillin in the treatment of acute pyelonephritis. (3396118)
1988
41
Acute pyelonephritis caused by Staphylococcus xylosus. (7130375)
1982
42
Intrarenal concentrations of ampicillin in acute pyelonephritis. (7294766)
1981
43
Hemagglutination of human type O erythrocytes, hemolysin production, and serogrouping of Escherichia coli isolates from patients with acute pyelonephritis, cystitis, and asymptomatic bacteriuria. (7011993)
1981
44
A clinical approach to the choice of antimicrobial agents. Case number 13: acute pyelonephritis. (7351516)
1980
45
The roentgenographic findings in acute pyelonephritis. (372597)
1979
46
Acute pyelonephritis in an adult gorilla (Gorilla gorilla). (633836)
1978
47
The urographic findings in acute pyelonephritis: non-obstructive hydronephrosis. (789916)
1976
48
Antibody-coated bacteria in the urine of obstetrical patients with acute pyelonephritis. (1092774)
1975
49
Acute urinary infections. Their course and outcome in general practice with special reference to chronic pyelonephritis. (13895588)
1962
50
Pyelitis or acute pyelonephritis. (14933263)
1952

Genetic Variations for Acute Pyelonephritis

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Expression for genes affiliated with Acute Pyelonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for genes affiliated with Acute Pyelonephritis

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12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Acute Pyelonephritis

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44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7CXCL10
2estrogen4410.6MBL2
3pge24410.5AQP2, POMC
4endotoxin4410.5CXCR2, ADM
5norepinephrine44 11 2412.4POMC, ADM
6rantes4410.2IL7, IL1R1, MBL2, CXCR1
7hydrocortisone44 2 59 1113.2AQP2, POMC, IL8, ADM
8h2o24410.1MIF, IL1R1, NAGLU
9grogamma4410.1IL8, CXCR1, CXCR2
10groalpha4410.0IL8, CXCR2, CXCR1, CXCL10
11superoxide44 2411.0CXCR2, MBL2
12homocysteine44 2411.0MIF, CRP, ADM, IL1R1, NAGLU
13etanercept44 49 1112.0IL8, CRP, TIMP1, IL1R1
14cyclosporin a44 28 5912.0IL1R1, NAGLU, AQP2, ADM, TNFRSF8
15grobeta4410.0IL8, CXCR1, CXCR2
16il 10449.9CXCL10, IL7, IL8, IL1R1
17infliximab44 49 1111.9CRP, IL1R1, TIMP1, CXCL10
18lipoteichoic acid449.9CXCR2, IL8, MBL2, IL1R1
19gold sodium thiomalate449.9NAGLU, IL8, IL1R1
20glucose449.9NAGLU, AQP2, ADM, NAMPT, POMC, FBP1
21ccl344 2810.9CXCR1, CXCL10, IL1R1, IL8
22neopterin449.8IL8, CXCL10, NAGLU, CRP, MBL2, IL1R1
23cyclophosphamide44 49 1111.8MBL2, IL1R1, NAGLU, MIF, IL7, CRP
24ccl444 2810.7TIMP1, CXCL10, IL1R1, IL7
25creatinine449.7CXCL10, NAGLU, NAMPT, AQP2, POMC, CRP
26oxygen44 2410.7CXCR1, CXCR2, IL8, MBL2, ADM, NAGLU
27tuberculin449.7MIF, TNFRSF8, MBL2
28losartan44 49 28 1112.7UGT1A1, CRP, ADM
29herbimycin a44 5910.7MIF, IL8, CXCR1, CXCR2, TIMP1
30leukotriene b444 59 2411.7CXCR1, IL8, IL7, IL1R1, CXCL10, CXCR2
31fibrinogen449.6IL1R1, IL7, NAMPT, MBL2, CRP, CXCR2
32lactate449.5TIMP1, CRP, MIF, NAGLU, IL1R1, IL8
33heparin44 28 11 2412.5IL1R1, IL8, IL7, CXCR2, TIMP1, NAGLU
34dexamethasone44 49 28 1112.4CXCR1, IL1R1, AQP2, NAMPT, POMC, UGT1A1
35paraffin449.3ADM, MIF, TIMP1, TNFRSF8, POMC, MBL2
36thymidine44 2410.3ADM, IL7, TNFRSF8, NAGLU, UGT1A1, IL1R1
37serine449.3TIMP1, IL8, IL1R1, MIF, CXCR2, POMC
38phosphatidylinositol449.3TIMP1, NAMPT, ADM, CXCR2, CXCR1, CXCL10
39genistein44 28 59 2 11 2414.3TIMP1, UGT1A1, MIF, CXCR2, CXCL10, IL7
40steroid449.2AQP2, MBL2, UGT1A1, ADM, IL7, POMC
41progesterone44 59 28 11 2413.1MBL2, POMC, ADM, TIMP1, UGT1A1, CXCL10
42cholesterol44 28 11 2412.1ADM, IL7, TIMP1, NAMPT, MBL2, UGT1A1
43retinoic acid44 249.9MIF, TIMP1, UGT1A1, ADM, LGALS7, IL7
44cysteine448.8ADM, TIMP1, NAGLU, MBL2, MIF, AQP2
45nitric oxide44 11 2410.8MIF, MBL2, TIMP1, ADM, CXCR2, IL1R1
46alanine448.6AQP2, TIMP1, IL7, CRP, POMC, NAGLU
47calcium44 49 11 2411.6MIF, TNFRSF8, MBL2, NAGLU, CXCR1, CXCL10
48tyrosine448.6CXCL10, ADM, IL1R1, TIMP1, TNFRSF8, IL7
49vegf448.6IL8, ADM, POMC, CRP, CXCR2, IL7
50lipid448.5AQP2, IL1R1, CXCL10, NAGLU, CXCR1, CXCR2

GO Terms for genes affiliated with Acute Pyelonephritis

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16Gene Ontology
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Cellular components related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9CRP, POMC, MIF, CXCL10, IL7, IL8
2extracellular regionGO:0055768.2ADM, TIMP1, MBL2, CRP, POMC, MIF

Biological processes related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.3CXCR1, CXCR2
2response to starvationGO:04259410.1AQP2, ADM, UGT1A1
3dendritic cell chemotaxisGO:00240710.1CXCR1, CXCR2
4opsonizationGO:00822810.0MBL2, CRP
5agingGO:00756810.0AQP2, ADM, CRP, TIMP1
6receptor internalizationGO:03162310.0ADM, IL8, CXCR1, CXCR2
7response to lipopolysaccharideGO:03249610.0UGT1A1, CXCL10, ADM, AQP2
8acute-phase responseGO:00695310.0CRP, UGT1A1, MBL2
9cell surface receptor signaling pathwayGO:0071669.8MIF, CXCR2, CXCR1, CXCL10, IL1R1
10cell-cell signalingGO:0072679.7POMC, NAMPT, CXCL10, IL7, ADM
11neutrophil activationGO:0421199.7IL8, CXCR2
12inflammatory responseGO:0069549.6CRP, MIF, CXCR2, CXCR1, CXCL10, IL8
13positive regulation of cell proliferationGO:0082849.5TIMP1, NAMPT, CXCR2, CXCL10, IL7, ADM
14signal transductionGO:0071659.0TNFRSF8, POMC, NAMPT, CXCR2, CXCL10, IL8

Molecular functions related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-8 bindingGO:01995910.1CXCR1, CXCR2
2interleukin-8 receptor activityGO:0049189.8CXCR1, CXCR2
3receptor bindingGO:0051029.4ADM, CXCL10, MIF, POMC, MBL2

Products for genes affiliated with Acute Pyelonephritis

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  • Antibodies
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Sources for Acute Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet