MCID: ACT042
MIFTS: 43

Acute Pyelonephritis malady

Nephrological diseases category
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Summaries for Acute Pyelonephritis

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MalaCards based summary: Acute Pyelonephritis, also known as acute pyelonephritis nos, is related to pyelonephritis and bacteriuria. An important gene associated with Acute Pyelonephritis is CXCR1 (chemokine (C-X-C motif) receptor 1), and among its related pathways are Carbon metabolism and Glycolysis and gluconeogenesis short map . The compounds 99mtc-dmsa and dmsa have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and neutrophil.

Aliases & Classifications for Acute Pyelonephritis

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Acute Pyelonephritis, Aliases & Descriptions:

Name: Acute Pyelonephritis 8 44 62
 
Acute Pyelonephritis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:559
ICD9CM27 590.1

Related Diseases for Acute Pyelonephritis

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Diseases in the Pyelonephritis family:

acute pyelonephritis Chronic Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis32.1CXCR1, CRP, NAGLU
2bacteriuria31.3CRP
3hydronephrosis30.9NAGLU
4pneumonia30.2NAGLU, CRP
5rheumatoid arthritis30.0NAGLU, CXCR1, CRP
6diabetes mellitus29.7CRP, FBP1, GOT1, NAGLU
7vesicoureteral reflux10.5
8cystitis10.5
9blindness10.5
10bacteremia10.4
11gallbladder disease10.4GOT1
12septic shock10.3
13metabolic acidosis10.3AQP2
14vascular disease10.2GOT1
15adult respiratory distress syndrome10.2
16arthritis10.2
17acute cystitis10.2
18osteomyelitis10.2
19prostatitis10.2
20sepsis10.2
21exanthem10.2GOT1, CRP
22chronic obstructive pulmonary disease10.2CXCR1, CRP
23leukopenia10.2GOT1, CRP
24fatty liver disease10.1CRP, GOT1
25diarrhea10.1GOT1, CRP
26acute myocardial infarction10.1NAGLU, CRP
27pancreatitis10.1GOT1, CRP
28galactosemia10.1CRP, GOT1
29proteinuria10.1CRP, NAGLU
30essential hypertension10.1AQP2, NAGLU
31diabetic nephropathy10.1AQP2, NAGLU
32primary hyperoxaluria10.0NAGLU, AQP2
33glomerulonephritis10.0
34hepatitis10.0
35nephrolithiasis10.0
36pseudohypoaldosteronism10.0
37renal glycosuria10.0
38spinal cord injury10.0
39thrombocytopenia10.0
40type 2 diabetes mellitus10.0
41perinephritis10.0
42anuria10.0
43carbuncle10.0
44splenic abscess10.0
45septic arthritis10.0
46kawasaki disease10.0
47renal fibrosis10.0
48melioidosis10.0
49hyperhomocysteinemia10.0
50subacute glomerulonephritis10.0

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to acute pyelonephritis

Symptoms for Acute Pyelonephritis

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Drugs & Therapeutics for Acute Pyelonephritis

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Drug clinical trials:

Search ClinicalTrials for Acute Pyelonephritis

Search NIH Clinical Center for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

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Anatomical Context for Acute Pyelonephritis

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MalaCards organs/tissues related to Acute Pyelonephritis:

32
Kidney, Testes, Neutrophil, Colon, Liver, Prostate, Whole blood, Cortex, Spinal cord, Thyroid, B cells, Endothelial

Animal Models for Acute Pyelonephritis or affiliated genes

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Publications for Acute Pyelonephritis

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Articles related to Acute Pyelonephritis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
The efficacy of non-carbapenem antibiotics for the treatment of community-onset acute pyelonephritis due to extended-spectrum I^-lactamase-producing Escherichia coli. (24928854)
2014
2
Are serum procalcitonin and interleukin-1 beta suitable markers for diagnosis of acute pyelonephritis in children? (24874931)
2014
3
Is the mean platelet volume a predictive marker for the diagnosis of acute pyelonephritis in children? (25367868)
2014
4
Effects of Gentamicin Monotherapy for the Initial Treatment of Community-Onset Complicated Non-Obstructive Acute Pyelonephritis Due to Enterobacteriaceae in Elderly and Non-Elderly Women. (24909648)
2014
5
The first case of atrial fibrillation-related graft kidney infarction following acute pyelonephritis. (24694493)
2014
6
Utility of non-enhanced magnetic resonance imaging to detect acute pyelonephritis. (24894941)
2014
7
Urinary concentration of cytokines in children with acute pyelonephritis. (23389820)
2013
8
The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis. (23052650)
2013
9
Enterococcus hirae-related acute pyelonephritis and cholangitis with bacteremia: an unusual infection in humans. (22313539)
2012
10
The influence of chronic renal failure on the spectrum and antimicrobial susceptibility of uropathogens in community-acquired acute pyelonephritis presenting as a positive urine culture. (21507269)
2011
11
Selection of first-line i.v. antibiotics for acute pyelonephritis in patients requiring emergency hospital admission. (20839025)
2011
12
A simple model to predict bacteremia in women with acute pyelonephritis. (21722666)
2011
13
Comparison of extended virulence genotypes for bacteria isolated from pediatric patients with urosepsis, acute pyelonephritis, and acute lobar nephronia. (20661102)
2010
14
Antibiotics for acute pyelonephritis in children. (17943796)
2007
15
Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)
2007
16
Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. (17763275)
2007
17
Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis. (17853184)
2007
18
Initial presentation of scintigraphic changes during the first episode of acute pyelonephritis in children: simultaneous evaluation with MAG3 and DMSA. (17690790)
2007
19
Oestroprogestagens and severe acute pyelonephritis: a casual or causal association? (16868038)
2006
20
Accurate diagnosis of acute pyelonephritis: How helpful is procalcitonin? (16894326)
2006
21
Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa. (14693524)
2004
22
Treatment of acute pyelonephritis in children. (14739166)
2004
23
Acute pyelonephritis: analysis of 52 cases. (12380905)
2002
24
Follow-up of acute pyelonephritis in children by Tc-99m DMSA scintigraphy: quantitative and qualitative assessment. (11317023)
2001
25
Aminoglycosides do not improve the efficacy of cephalosporins for treatment of acute pyelonephritis in women. (9181655)
1997
26
Hospitalization for acute pyelonephritis in Manitoba, Canada, during the period from 1989 to 1992; impact of diabetes, pregnancy, and aboriginal origin. (8783709)
1996
27
Prospective, randomized, controlled study comparing two dosing regimens of gentamicin/oral ciprofloxacin switch therapy for acute pyelonephritis. (8879853)
1996
28
Treatment trials on children with acute pyelonephritis. (7917850)
1994
29
Duration of antimicrobial treatment and the use of drug combinations for the treatment of uncomplicated acute pyelonephritis. (8050796)
1994
30
Functional parameters and 99mtechnetium-dimercaptosuccinic acid scan in acute pyelonephritis. (7696107)
1994
31
Vesicoureteral reflux: an accurate predictor of acute pyelonephritis in childhood urinary tract infection? (8284391)
1994
32
Sexual acquisition of acute pyelonephritis in a man. (8460339)
1993
33
The sensitivity of renal scintigraphy and sonography in detecting nonobstructive acute pyelonephritis. (1640534)
1992
34
Comparison of ciprofloxacin with netilmicin for the treatment of acute pyelonephritis. (1553112)
1992
35
Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. (1651644)
1991
36
Attenuation of antibody response to acute pyelonephritis by treatment with antibiotics. (1804007)
1991
37
Long-term risks of acute pyelonephritis. (2179757)
1990
38
Special virulence of the Escherichia coli O1:K1:H7 clone in acute pyelonephritis. (2661790)
1989
39
Acute pyelonephritis in pregnancy at Ramathibodi Hospital: a descriptive epidemiological study. (3183551)
1988
40
The intravenous pyelogram in acute pyelonephritis. (3052346)
1988
41
The characteristics and hospital course of patients admitted for presumed acute pyelonephritis. (3543268)
1987
42
Acute pyelonephritis in pregnancy. (3791931)
1986
43
Urinary immunoglobulins in healthy individuals and children with acute pyelonephritis. (3890147)
1985
44
Urinary tract infection during pregnancy. Asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis. (6374641)
1984
45
Acute pyelonephritis in the elderly. (7079812)
1982
46
Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis. (7014730)
1981
47
Intrarenal concentrations of ampicillin in acute pyelonephritis. (7294766)
1981
48
A clinical approach to the choice of antimicrobial agents. Case number 13: acute pyelonephritis. (7351516)
1980
49
Gallium-67 radionuclide imaging in acute pyelonephritis. (6766013)
1980
50
CLINICAL pathologic conference: acute and subacute glomerulonephritis with acute pyelonephritis. (13061782)
1953

Variations for Acute Pyelonephritis

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Expression for genes affiliated with Acute Pyelonephritis

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Expression patterns in normal tissues for genes affiliated with Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for genes affiliated with Acute Pyelonephritis

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Pathways related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.1FBP1, GOT1
2
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.1FBP1, GOT1
3
Show member pathways
malate-aspartate shuttle37
glycogen biosynthesis II (from UDP-D-Glucose)37
9.1FBP1, GOT1
4
Show member pathways
8.7NAGLU, FBP1, GOT1

Compounds for genes affiliated with Acute Pyelonephritis

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Compounds related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
199mtc-dmsa449.9CRP, NAGLU
2dmsa449.9CRP, NAGLU
3perindopril44 50 1111.9NAGLU, CRP
4c-peptide449.8CRP, NAGLU
5neopterin449.8NAGLU, CRP
6malondialdehyde449.8NAGLU, CRP
7losartan44 50 28 1112.8CRP, NAGLU
8uric acid44 2410.8NAGLU, CRP
9latex449.8CRP, NAGLU
10mercury449.8NAGLU, AQP2
11desmopressin44 61 28 1112.8AQP2, NAGLU
12homocysteine44 2410.8NAGLU, CRP
13furosemide44 61 28 50 24 1114.8NAGLU, AQP2
14mannitol44 1110.7CRP, NAGLU
15lithium44 50 24 1112.7NAGLU, AQP2
16hydrochlorothiazide44 28 50 24 1113.7CRP, AQP2
17citrate449.6NAGLU, CRP
18biotin44 24 1111.6CRP, AQP2
19cytochalasin d44 6110.6CXCR1, AQP2
20urea44 24 1111.6NAGLU, AQP2
21cyclophosphamide44 50 1111.6CRP, NAGLU
22endotoxin449.5CXCR1, CRP
23vitamin a44 24 1111.5CRP, NAGLU
24creatinine449.2AQP2, NAGLU, CRP
25alanine449.1AQP2, NAGLU, CRP
26folate449.0CRP, FBP1
27Water248.9NAGLU, AQP2, FBP1
28lipid448.8AQP2, NAGLU, CXCR1, CRP
29cysteine448.7CXCR1, NAGLU, AQP2
30calcium44 50 24 1111.7CRP, CXCR1, NAGLU, AQP2
31glucose448.4CRP, NAGLU, AQP2, FBP1

GO Terms for genes affiliated with Acute Pyelonephritis

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Cellular components related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057648.6NAGLU, AQP2, GOT1
2extracellular vesicular exosomeGO:0700628.1NAGLU, AQP2, FBP1, GOT1

Biological processes related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose metabolic processGO:0060069.1FBP1, GOT1
2agingGO:0075689.0CRP, AQP2
3gluconeogenesisGO:0060949.0FBP1, GOT1
4carbohydrate metabolic processGO:0059758.7NAGLU, FBP1, GOT1

Products for genes affiliated with Acute Pyelonephritis

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Sources for Acute Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet