MCID: ACT042
MIFTS: 42

Acute Pyelonephritis malady

Nephrological diseases category

Summaries for Acute Pyelonephritis

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34MalaCards
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MalaCards: Acute Pyelonephritis, also known as acute pyelonephritis nos, is related to pyelonephritis and bacteriuria. An important gene associated with Acute Pyelonephritis is CXCR1 (chemokine (C-X-C motif) receptor 1), and among its related pathways are Carbon metabolism and Glycolysis and gluconeogenesis short map . The compounds 99mtc-dmsa and dmsa have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and liver.

Aliases & Classifications for Acute Pyelonephritis

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

acute pyelonephritis 9 46 63
acute pyelonephritis nos 9


External Ids:

Disease Ontology9 DOID:559
ICD9CM28 590.1

Related Diseases for Acute Pyelonephritis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to acute pyelonephritis

Symptoms for Acute Pyelonephritis

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Drugs & Therapeutics for Acute Pyelonephritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Acute Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Acute Pyelonephritis

Search NIH Clinical Center for Acute Pyelonephritis

Search CenterWatch for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

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Anatomical Context for Acute Pyelonephritis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Acute Pyelonephritis:

34
Kidney, Testes, Liver, Prostate, Colon, Whole blood, Thyroid, B cells, Spinal cord, Cortex

Animal Models for Acute Pyelonephritis or affiliated genes

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Publications for Acute Pyelonephritis

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53PubMed
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Articles related to Acute Pyelonephritis:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Urinary concentration of cytokines in children with acute pyelonephritis. (23389820)
2013
2
The effect of vitamin E or vitamin A on the prevention of renal scarring in children with acute pyelonephritis. (23052650)
2013
3
Enterococcus hirae-related acute pyelonephritis and cholangitis with bacteremia: an unusual infection in humans. (22313539)
2012
4
The influence of chronic renal failure on the spectrum and antimicrobial susceptibility of uropathogens in community-acquired acute pyelonephritis presenting as a positive urine culture. (21507269)
2011
5
Selection of first-line i.v. antibiotics for acute pyelonephritis in patients requiring emergency hospital admission. (20839025)
2011
6
A simple model to predict bacteremia in women with acute pyelonephritis. (21722666)
2011
7
Comparison of extended virulence genotypes for bacteria isolated from pediatric patients with urosepsis, acute pyelonephritis, and acute lobar nephronia. (20661102)
2010
8
Antibiotics for acute pyelonephritis in children. (17943796)
2007
9
Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)
2007
10
Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. (17763275)
2007
11
Maternal serum soluble CD30 is increased in pregnancies complicated with acute pyelonephritis. (17853184)
2007
12
Initial presentation of scintigraphic changes during the first episode of acute pyelonephritis in children: simultaneous evaluation with MAG3 and DMSA. (17690790)
2007
13
Oestroprogestagens and severe acute pyelonephritis: a casual or causal association? (16868038)
2006
14
Accurate diagnosis of acute pyelonephritis: How helpful is procalcitonin? (16894326)
2006
15
Clarithromycin: immunomodulatory therapy of experimental sepsis and acute pyelonephritis by Escherichia coli. (15764190)
2005
16
Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa. (14693524)
2004
17
Treatment of acute pyelonephritis in children. (14739166)
2004
18
Predictors of receipt of a fluoroquinolone versus trimethoprim-sulfamethoxazole for treatment of acute pyelonephritis in women in Manitoba, Canada. (15386718)
2004
19
Acute pyelonephritis: analysis of 52 cases. (12380905)
2002
20
Acute pyelonephritis causing acute renal allograft dysfunction. (12899217)
2002
21
Follow-up of acute pyelonephritis in children by Tc-99m DMSA scintigraphy: quantitative and qualitative assessment. (11317023)
2001
22
Aminoglycosides do not improve the efficacy of cephalosporins for treatment of acute pyelonephritis in women. (9181655)
1997
23
Hospitalization for acute pyelonephritis in Manitoba, Canada, during the period from 1989 to 1992; impact of diabetes, pregnancy, and aboriginal origin. (8783709)
1996
24
Prospective, randomized, controlled study comparing two dosing regimens of gentamicin/oral ciprofloxacin switch therapy for acute pyelonephritis. (8879853)
1996
25
Treatment trials on children with acute pyelonephritis. (7917850)
1994
26
Duration of antimicrobial treatment and the use of drug combinations for the treatment of uncomplicated acute pyelonephritis. (8050796)
1994
27
Functional parameters and 99mtechnetium-dimercaptosuccinic acid scan in acute pyelonephritis. (7696107)
1994
28
Vesicoureteral reflux: an accurate predictor of acute pyelonephritis in childhood urinary tract infection? (8284391)
1994
29
Sexual acquisition of acute pyelonephritis in a man. (8460339)
1993
30
The sensitivity of renal scintigraphy and sonography in detecting nonobstructive acute pyelonephritis. (1640534)
1992
31
Comparison of ciprofloxacin with netilmicin for the treatment of acute pyelonephritis. (1553112)
1992
32
Diagnosis of acute pyelonephritis in children: comparison of sonography and 99mTc-DMSA scintigraphy. (1651644)
1991
33
Attenuation of antibody response to acute pyelonephritis by treatment with antibiotics. (1804007)
1991
34
Long-term risks of acute pyelonephritis. (2179757)
1990
35
Special virulence of the Escherichia coli O1:K1:H7 clone in acute pyelonephritis. (2661790)
1989
36
Acute pyelonephritis in pregnancy at Ramathibodi Hospital: a descriptive epidemiological study. (3183551)
1988
37
The intravenous pyelogram in acute pyelonephritis. (3052346)
1988
38
The characteristics and hospital course of patients admitted for presumed acute pyelonephritis. (3543268)
1987
39
Acute pyelonephritis in pregnancy. (3791931)
1986
40
Adult respiratory distress syndrome as a complication of acute pyelonephritis during pregnancy: case report and discussion. (3945462)
1986
41
Urinary immunoglobulins in healthy individuals and children with acute pyelonephritis. (3890147)
1985
42
Urinary tract infection during pregnancy. Asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis. (6374641)
1984
43
Acute pyelonephritis in the elderly. (7079812)
1982
44
Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis. (7014730)
1981
45
Intrarenal concentrations of ampicillin in acute pyelonephritis. (7294766)
1981
46
A clinical approach to the choice of antimicrobial agents. Case number 13: acute pyelonephritis. (7351516)
1980
47
Gallium-67 radionuclide imaging in acute pyelonephritis. (6766013)
1980
48
Acute pyelonephritis in a transplant patient with an ileal loop mimicking rejection. (785033)
1976
49
An ultrastructural study of the renal medulla in experimental acute pyelonephritis. (1099824)
1975
50
CLINICAL pathologic conference: acute and subacute glomerulonephritis with acute pyelonephritis. (13061782)
1953

Variations for Acute Pyelonephritis

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Expression for genes affiliated with Acute Pyelonephritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for genes affiliated with Acute Pyelonephritis

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Sources:
51PathCards, 31KEGG, 52PharmGKB, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome
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Pathways related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
9.1FBP1, GOT1
2
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
9.1FBP1, GOT1
3
Show member pathways
malate-aspartate shuttle39
glycogen biosynthesis II (from UDP-D-Glucose)39
9.1FBP1, GOT1
4
Show member pathways
8.7NAGLU, FBP1, GOT1

Compounds for genes affiliated with Acute Pyelonephritis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
199mtc-dmsa469.9CRP, NAGLU
2dmsa469.9CRP, NAGLU
3perindopril46 52 1211.9NAGLU, CRP
4c-peptide469.8CRP, NAGLU
5neopterin469.8NAGLU, CRP
6malondialdehyde469.8NAGLU, CRP
7losartan46 52 30 1212.8CRP, NAGLU
8uric acid46 2510.8NAGLU, CRP
9latex469.8CRP, NAGLU
10mercury469.8NAGLU, AQP2
11desmopressin46 62 30 1212.8AQP2, NAGLU
12homocysteine46 2510.8NAGLU, CRP
13furosemide46 62 30 52 25 1214.8NAGLU, AQP2
14mannitol46 1210.7CRP, NAGLU
15lithium46 52 25 1212.7NAGLU, AQP2
16hydrochlorothiazide46 30 52 25 1213.7CRP, AQP2
17citrate469.6NAGLU, CRP
18biotin46 25 1211.6CRP, AQP2
19cytochalasin d46 6210.6CXCR1, AQP2
20urea46 25 1211.6NAGLU, AQP2
21cyclophosphamide46 52 1211.6CRP, NAGLU
22endotoxin469.5CXCR1, CRP
23vitamin a46 25 1211.5CRP, NAGLU
24creatinine469.2AQP2, NAGLU, CRP
25alanine469.1AQP2, NAGLU, CRP
26folate469.0CRP, FBP1
27Water258.9NAGLU, AQP2, FBP1
28lipid468.8AQP2, NAGLU, CXCR1, CRP
29cysteine468.7CXCR1, NAGLU, AQP2
30calcium46 52 25 1211.7CRP, CXCR1, NAGLU, AQP2
31glucose468.4CRP, NAGLU, AQP2, FBP1

GO Terms for genes affiliated with Acute Pyelonephritis

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Sources:
17Gene Ontology
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Cellular components related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057648.6NAGLU, AQP2, GOT1
2extracellular vesicular exosomeGO:0700628.1NAGLU, AQP2, FBP1, GOT1

Biological processes related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose metabolic processGO:0060069.1FBP1, GOT1
2agingGO:0075689.0CRP, AQP2
3gluconeogenesisGO:0060949.0FBP1, GOT1
4carbohydrate metabolic processGO:0059758.7NAGLU, FBP1, GOT1

Products for genes affiliated with Acute Pyelonephritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Pyelonephritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet