MCID: ACT042
MIFTS: 52

Acute Pyelonephritis malady

Summaries for Acute Pyelonephritis

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32MalaCards
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MalaCards: Acute Pyelonephritis, also known as acute pyelonephritis nos, is related to pyelonephritis and vesicoureteral reflux. An important gene associated with Acute Pyelonephritis is CXCR1 (chemokine (C-X-C motif) receptor 1), and among its related pathways are Cell adhesion ECM remodeling and Spinal Cord Injury. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and testes, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Acute Pyelonephritis

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

acute pyelonephritis 8 44 60
acute pyelonephritis nos 8


External Ids:

Disease Ontology8 DOID:559
ICD9CM27 590.1

Related Diseases for Acute Pyelonephritis

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17GeneCards, 18GeneDecks
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Diseases in the Pyelonephritis family:

acute pyelonephritis Chronic Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1pyelonephritis32.0CRP, NAGLU, CXCR1
2vesicoureteral reflux30.7NAGLU
3bacteriuria30.6CRP
4cystitis30.6NAGLU
5osteomyelitis30.2CRP
6hydronephrosis30.2NAGLU
7arthritis30.2TIMP1, CRP, POMC, MIF, CXCR2, CXCR1
8hepatitis29.9UGT1A1, CXCL10
9thyroiditis29.9POMC, MBL2
10thrombocytopenia29.9GOT1, IL7, IL1R1
11glomerulonephritis29.9IL1R1, NAGLU, MIF, MBL2
12kawasaki disease29.9TIMP1, MBL2, CRP, ADM
13influenza29.9LGALS7, IL7, CXCL10, MBL2
14diabetes mellitus29.9GOT1, IL1R1, NAMPT, NAGLU, POMC, FBP1
15pneumonia29.9MBL2, CRP, NAGLU, CXCR2, CXCL10, IL8
16rheumatoid arthritis29.9TNFRSF8, MBL2, TIMP1, CRP, MIF, NAGLU
17acute cystitis10.4
18chronic pyelonephritis10.2
19adult respiratory distress syndrome10.1
20adult syndrome10.1
21prostatitis10.1
22peritonitis10.0CRP
23coronary heart disease10.0CRP
24aortic aneurysm10.0CRP
25crohn's disease10.0CRP
26familial mediterranean fever10.0CRP
27rheumatic disease10.0CRP
28acute thyroiditis10.0
29anuria10.0
30perinephritis10.0
31epidural abscess10.0
32pseudohypoaldosteronism10.0
33subacute glomerulonephritis10.0
34renal glycosuria10.0
35nephrolithiasis10.0
36carbuncle10.0
37hyperhomocysteinemia10.0
38ureterocele10.0
39septic arthritis10.0
40acute cholangitis10.0
41shwartzman phenomenon10.0
42phaeochromocytoma10.0
43acute cervicitis10.0
44candidiasis10.0
45cervicitis10.0
46cholangitis10.0
47interstitial nephritis10.0
48leiomyoma10.0
49ovarian cyst10.0
50pyelitis10.0

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to acute pyelonephritis

Clinical Features for Acute Pyelonephritis

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Drugs & Therapeutics for Acute Pyelonephritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Acute Pyelonephritis

Drug clinical trials:

Search ClinicalTrials for Acute Pyelonephritis

Search NIH Clinical Center for Acute Pyelonephritis

Search CenterWatch for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

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Anatomical Context for Acute Pyelonephritis

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32MalaCards
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MalaCards organs/tissues related to Acute Pyelonephritis:

32
Kidney, Liver, Testes, Prostate, Colon, Thyroid, Whole blood, Spinal cord, Cortex, B cells

Animal Models for Acute Pyelonephritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Pyelonephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0POMC, NAGLU, CXCR2, IL1R1, ADM, AQP2
2MP:00053858.9CRP, POMC, NAGLU, CXCR2, CXCL10, IL1R1
3MP:00053768.3TIMP1, MBL2, CRP, POMC, MIF, NAMPT
4MP:00053977.8MIF, POMC, TNFRSF8, MBL2, TIMP1, NAGLU
5MP:00053877.7ADM, TIMP1, MBL2, TNFRSF8, CRP, POMC

Publications for Acute Pyelonephritis

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50PubMed
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Articles related to Acute Pyelonephritis:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Clinical characteristics of community-acquired acute pyelonephritis caused by ESBL-producing pathogens in South Korea. (23504297)
2013
2
Use of gentamicin for women with community-acquired uncomplicated acute pyelonephritis caused by gentamicin-susceptible or -resistant Escherichia coli: 10-year experience. (23473263)
2013
3
Etiology of acute pyelonephritis: species composition and populational levels of urine microflora. (23787506)
2013
4
Unusual cause of acute renal failure from acute pyelonephritis due to Klebsiella pneumoniae in a young woman. (23595405)
2013
5
Randomized trial of oral versus sequential IV/oral antibiotic for acute pyelonephritis in children. (22291112)
2012
6
Risk factors for renal scar formation in infants with first episode of acute pyelonephritis: a prospective clinical study. (22264451)
2012
7
In vivo susceptibility of ESBL producing Escherichia coli to ceftriaxone in children with acute pyelonephritis. (22826985)
2012
8
Renal power Doppler ultrasonographic evaluation of children with acute pyelonephritis. (22071640)
2011
9
Impressive renal damage after acute pyelonephritis in a child. (20157735)
2010
10
Acute pyelonephritis: clinical characteristics and the role of the surgical treatment. (19399273)
2009
11
Obstructive uropathy with acute pyelonephritis induced by a voluminous postmenopausal uterine leiomyoma. (19346200)
2009
12
Pyelonephritis presenting with severe acute renal failure. (18574576)
2008
13
Oestroprogestagens and severe acute pyelonephritis: a casual or causal association? (16868038)
2006
14
Serum and urine levels of interleukin-6 and interleukin-8 in children with acute pyelonephritis. (17374489)
2006
15
Correlation of renal ultrasonographic findings with inflammatory volume from dimercaptosuccinic acid renal scans in children with acute pyelonephritis. (15592072)
2005
16
Acute pyelonephritis and renal scarring in Kuwaiti children: a follow-up study using 99mTc DMSA renal scintigraphy. (15973531)
2005
17
Evaluation of the use of DMSA in culture positive UTI and culture negative acute pyelonephritis. (16085971)
2005
18
Increased concentration of the complement split product C5a in acute pyelonephritis during pregnancy. (16147833)
2005
19
Predictors of receipt of a fluoroquinolone versus trimethoprim-sulfamethoxazole for treatment of acute pyelonephritis in women in Manitoba, Canada. (15386718)
2004
20
Procalcitonin as a marker of acute pyelonephritis. (12721819)
2003
21
Definition of acute pyelonephritis vs the urosepsis syndrome. (14581259)
2003
22
Acute pyelonephritis causing acute renal allograft dysfunction. (12899217)
2002
23
Randomised controlled trial of three day versus 10 day intravenous antibiotics in acute pyelonephritis: effect on renal scarring. (11207174)
2001
24
Does urinary tract ultrasonography at hospitalization for acute pyelonephritis predict vesicoureteral reflux? (11371951)
2001
25
Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). (10589881)
1999
26
The importance of 99Tcm-DMSA renal scintigraphy in the follow-up of acute pyelonephritis in children: comparison with urographic data. (9853352)
1998
27
Virulence factors and O groups of Escherichia coli isolates from patients with acute pyelonephritis, cystitis and asymptomatic bacteriuria. (8817199)
1996
28
Tumour necrosis factor soluble receptors I and II and interleukin-1 receptor antagonist in acute pyelonephritis in relation to bacterial virulence-associated traits and renal function. (8941580)
1996
29
Cytokine and lymphocyte activation during experimental acute pyelonephritis. (7618233)
1995
30
Duration of antimicrobial treatment and the use of drug combinations for the treatment of uncomplicated acute pyelonephritis. (8050796)
1994
31
Functional parameters and 99mtechnetium-dimercaptosuccinic acid scan in acute pyelonephritis. (7696107)
1994
32
The plasma interleukin-6 and stress hormone responses to acute pyelonephritis. (7930378)
1994
33
The value of urinalysis in differentiating acute pyelonephritis from lower urinary tract infection in febrile infants. (7808845)
1994
34
Contribution of Proteus mirabilis urease to persistence, urolithiasis, and acute pyelonephritis in a mouse model of ascending urinary tract infection. (8514376)
1993
35
Renal ultrasonographic correlates of acute pyelonephritis. (1571421)
1992
36
Normokalaemic pseudohypoaldosteronism is present in children with acute pyelonephritis. (1498506)
1992
37
Efficacy of long-term antimicrobial prophylaxis after acute pyelonephritis in pregnancy. (1853171)
1991
38
Association of acute pyelonephritis with pulmonary complications in pregnancy. A report of two cases. (2352253)
1990
39
Cefetamet pivoxil in acute pyelonephritis: an open study. (2188796)
1990
40
Acute pyelonephritis in pregnancy at Ramathibodi Hospital: a descriptive epidemiological study. (3183551)
1988
41
A novel use of fine-needle aspiration biopsy: documentation of acute pyelonephritis of the transplanted kidney. (3043822)
1988
42
Antibody-dependent cell-mediated cytotoxicity against Tamm-Horsfall protein in acute pyelonephritis. (3280502)
1988
43
The characteristics and hospital course of patients admitted for presumed acute pyelonephritis. (3543268)
1987
44
Acute pyelonephritis. (3576850)
1987
45
Urinary immunoglobulins in healthy individuals and children with acute pyelonephritis. (3890147)
1985
46
Acute pyelonephritis as a cause of late transplant dysfunction. (3881021)
1985
47
Epidemic outbreaks of acute pyelonephritis caused by nosocomial spread of P fimbriated Escherichia coli in children. (6149248)
1984
48
Acute pyelonephritis in 48-year-old man. (7321121)
1981
49
Elevated plasma renin activity in patients with acute pyelonephritis. (694921)
1978
50
Transient renal dysfunction associated with acute pyelonephritis of pregnancy. (1097976)
1975

Genetic Variations for Acute Pyelonephritis

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Expression for genes affiliated with Acute Pyelonephritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for genes affiliated with Acute Pyelonephritis

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12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 53Reactome
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Compounds for genes affiliated with Acute Pyelonephritis

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44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7CXCL10
2estrogen4410.6MBL2
3pge24410.5POMC, AQP2
4endotoxin4410.5CXCR2, ADM
5norepinephrine44 11 2412.4ADM, POMC
6rantes4410.2MBL2, CXCR1, IL1R1, IL7
7hydrocortisone44 2 59 1113.2POMC, IL8, ADM, AQP2
8h2o24410.1IL1R1, NAGLU, MIF
9grogamma4410.1CXCR2, CXCR1, IL8
10groalpha4410.0IL8, CXCL10, CXCR1, CXCR2
11superoxide44 2411.0CXCR2, MBL2
12homocysteine44 2411.0CRP, MIF, NAGLU, IL1R1, ADM
13etanercept44 49 1112.0TIMP1, CRP, IL1R1, IL8
14cyclosporin a44 28 5912.0TNFRSF8, NAGLU, IL1R1, ADM, AQP2
15grobeta4410.0IL8, CXCR1, CXCR2
16il 10449.9CXCL10, IL1R1, IL7, IL8
17infliximab44 49 1111.9TIMP1, CRP, CXCL10, IL1R1
18lipoteichoic acid449.9MBL2, CXCR2, IL1R1, IL8
19gold sodium thiomalate449.9NAGLU, IL1R1, IL8
20glucose449.9FBP1, POMC, NAGLU, NAMPT, ADM, AQP2
21ccl344 2810.9CXCR1, CXCL10, IL1R1, IL8
22neopterin449.8MBL2, CRP, NAGLU, CXCL10, IL1R1, IL8
23cyclophosphamide44 49 1111.8MBL2, CRP, MIF, NAGLU, IL1R1, IL7
24ccl444 2810.7TIMP1, CXCL10, IL1R1, IL7
25creatinine449.7MBL2, CRP, POMC, NAGLU, NAMPT, CXCL10
26oxygen44 2410.7MBL2, NAGLU, CXCR2, CXCR1, IL8, ADM
27tuberculin449.7MBL2, TNFRSF8, MIF
28losartan44 49 28 1112.7ADM, CRP, UGT1A1
29herbimycin a44 5910.7TIMP1, MIF, CXCR2, CXCR1, IL8
30leukotriene b444 59 2411.7CXCR2, CXCR1, CXCL10, IL1R1, IL7, IL8
31fibrinogen449.6MBL2, CRP, NAMPT, CXCR2, IL1R1, IL7
32lactate449.5TIMP1, CRP, MIF, NAGLU, IL1R1, IL8
33heparin44 28 11 2412.5TIMP1, NAGLU, CXCR2, IL1R1, IL7, IL8
34dexamethasone44 49 28 1112.4AQP2, TIMP1, UGT1A1, POMC, NAMPT, CXCR1
35paraffin449.3TIMP1, MBL2, TNFRSF8, POMC, MIF, IL1R1
36thymidine44 2410.3TNFRSF8, UGT1A1, MIF, NAGLU, CXCL10, IL1R1
37serine449.3TIMP1, POMC, MIF, CXCR2, IL1R1, IL8
38phosphatidylinositol449.3TIMP1, NAMPT, CXCR2, CXCR1, CXCL10, IL1R1
39genistein44 28 59 2 11 2414.3TIMP1, UGT1A1, MIF, CXCR2, CXCR1, CXCL10
40steroid449.2MBL2, UGT1A1, POMC, MIF, NAGLU, IL1R1
41progesterone44 59 28 11 2413.1TIMP1, MBL2, UGT1A1, POMC, CXCL10, IL1R1
42cholesterol44 28 11 2412.1TIMP1, MBL2, UGT1A1, CRP, NAGLU, NAMPT
43retinoic acid44 249.9TIMP1, UGT1A1, MIF, CXCR2, CXCR1, CXCL10
44cysteine448.8TIMP1, MBL2, MIF, NAGLU, CXCR2, CXCR1
45nitric oxide44 11 2410.8TIMP1, MBL2, MIF, NAGLU, CXCR2, CXCL10
46alanine448.6TIMP1, UGT1A1, CRP, POMC, MIF, NAGLU
47calcium44 49 11 2411.6MBL2, TNFRSF8, CRP, MIF, NAGLU, CXCR2
48tyrosine448.6TIMP1, MBL2, TNFRSF8, UGT1A1, MIF, CXCR2
49vegf448.6TIMP1, MBL2, CRP, POMC, MIF, CXCR2
50lipid448.5NAGLU, MIF, CRP, TNFRSF8, MBL2, NAMPT

GO Terms for genes affiliated with Acute Pyelonephritis

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16Gene Ontology
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Cellular components related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9CRP, POMC, MIF, CXCL10, IL7, IL8
2extracellular regionGO:0055768.2ADM, TIMP1, MBL2, CRP, POMC, MIF

Biological processes related to Acute Pyelonephritis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.3CXCR1, CXCR2
2response to starvationGO:04259410.1AQP2, ADM, UGT1A1
3dendritic cell chemotaxisGO:00240710.1CXCR1, CXCR2
4opsonizationGO:00822810.0MBL2, CRP
5agingGO:00756810.0AQP2, ADM, CRP, TIMP1
6receptor internalizationGO:03162310.0ADM, IL8, CXCR1, CXCR2
7response to lipopolysaccharideGO:03249610.0UGT1A1, CXCL10, ADM, AQP2
8acute-phase responseGO:00695310.0CRP, UGT1A1, MBL2
9cell surface receptor signaling pathwayGO:0071669.8MIF, CXCR2, CXCR1, CXCL10, IL1R1
10cell-cell signalingGO:0072679.7POMC, NAMPT, CXCL10, IL7, ADM
11neutrophil activationGO:0421199.7IL8, CXCR2
12inflammatory responseGO:0069549.6CRP, MIF, CXCR2, CXCR1, CXCL10, IL8
13positive regulation of cell proliferationGO:0082849.5TIMP1, NAMPT, CXCR2, CXCL10, IL7, ADM
14signal transductionGO:0071659.0TNFRSF8, POMC, NAMPT, CXCR2, CXCL10, IL8

Molecular functions related to Acute Pyelonephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-8 bindingGO:01995910.1CXCR1, CXCR2
2interleukin-8 receptor activityGO:0049189.8CXCR1, CXCR2
3receptor bindingGO:0051029.4ADM, CXCL10, MIF, POMC, MBL2

Products for genes affiliated with Acute Pyelonephritis

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Sources for Acute Pyelonephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet