MCID: ACT042
MIFTS: 48

Acute Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Acute Pyelonephritis

MalaCards integrated aliases for Acute Pyelonephritis:

Name: Acute Pyelonephritis 12 51 14 69
Acute Pyelonephritis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:559
ICD10 32 N10
ICD9CM 34 590.1
NCIt 46 C123215
UMLS 69 C0520575

Summaries for Acute Pyelonephritis

MalaCards based summary : Acute Pyelonephritis, also known as acute pyelonephritis nos, is related to cystitis and pyelitis. An important gene associated with Acute Pyelonephritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Cefixime and Ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and neutrophil, and related phenotypes are cardiovascular system and immune system

Related Diseases for Acute Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Acute Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 cystitis 30.5 CRP CXCL8 IL6
2 pyelitis 29.9 CRP CXCR1
3 bacteriuria 29.9 CXCL8 CXCR1 CXCR2 IL6
4 prostatitis 29.8 CXCL8 IL10 IL6
5 adult respiratory distress syndrome 29.8 CXCL8 IL10 IL6
6 osteomyelitis 29.8 CXCL8 IL10 IL6
7 cholangitis 29.7 ALB CRP IL6
8 acute cystitis 29.6 ALB CRP CXCL8 IL6
9 brucellosis 29.3 CRP CXCL8 IL10 IL6
10 pneumonia 29.3 CRP CXCL8 IL10 IL6
11 rheumatoid arthritis 29.1 CRP CXCL8 IL10 IL6
12 mycobacterium tuberculosis 1 29.0 CXCL10 CXCR2 IL10
13 kawasaki disease 28.7 ADM ALB CRP IL10 IL6
14 pyelonephritis 28.6 ALB CRP CXCL8 CXCR1 CXCR2 IL10
15 cold agglutinin disease 10.5 CRP IL6
16 diabetic foot ulcers 10.5 CRP IL6
17 cryopyrin-associated periodic syndrome 10.5 CRP IL6
18 neutrophilia, hereditary 10.5 CRP IL6
19 acute cholangitis 10.5 CRP IL6
20 cardiogenic shock 10.5 CRP IL6
21 uremic pruritus 10.5 CRP IL6
22 spinal disease 10.5 CRP IL6
23 castleman disease 10.5 CRP IL6
24 recurrent corneal erosion 10.5 CXCL8 IL6
25 bagassosis 10.5 CXCL8 IL6
26 slow-channel congenital myasthenic syndrome 10.5 CRP CXCL8
27 angina pectoris 10.5 CRP IL6
28 streptococcal toxic-shock syndrome 10.5 CXCL8 IL6
29 viral pneumonia 10.5 CRP IL6
30 papillary conjunctivitis 10.4 CXCL8 IL6
31 cecal disease 10.4 CRP IL6
32 cardiac rupture 10.4 CRP CXCL8
33 relapsing polychondritis 10.4 CRP IL6
34 central nervous system vasculitis 10.4 CRP IL6
35 subacute thyroiditis 10.4 CRP IL6
36 intussusception 10.4 CRP IL6
37 acute monoblastic leukemia 10.4 CXCL8 IL6
38 meconium aspiration syndrome 10.4 CXCL8 IL6
39 vaginal disease 10.4 CXCL8 IL6
40 vaginitis 10.4 CXCL8 IL6
41 decubitus ulcer 10.4 ALB CRP
42 euthyroid sick syndrome 10.4 ALB IL6
43 ischemic heart disease 10.4 CRP IL6
44 preterm premature rupture of the membranes 10.4 CXCL8 IL6
45 mesenteric lymphadenitis 10.3 CRP IL6
46 eye lymphoma 10.3 IL10 IL6
47 immune suppression 10.3 IL10 IL6
48 necrotizing fasciitis 10.3 CXCL8 IL6
49 transient arthritis 10.3 ALB IL6
50 tungiasis 10.3 CXCL8 IL10

Graphical network of the top 20 diseases related to Acute Pyelonephritis:



Diseases related to Acute Pyelonephritis

Symptoms & Phenotypes for Acute Pyelonephritis

MGI Mouse Phenotypes related to Acute Pyelonephritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 PGF ADM CRP CXCL10 CXCR2 IL10
2 immune system MP:0005387 9.81 ADM CRP CXCL10 CXCR1 CXCR2 IL10
3 liver/biliary system MP:0005370 9.43 ADM ALB CXCR2 IL10 IL6 NAGLU
4 neoplasm MP:0002006 9.02 PGF ALB CXCR2 IL10 IL6

Drugs & Therapeutics for Acute Pyelonephritis

Drugs for Acute Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefixime Approved, Investigational Phase 4 79350-37-1 5362065 54362
2
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
3
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
4
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
5
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
6
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 85721-33-1 2764
7
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
8
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
10
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
12 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2
14 Fluoroquinolones Phase 4,Phase 2
15 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
16 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2
17 Antitubercular Agents Phase 4,Phase 3
18 Antimalarials Phase 4,Phase 3
19 Antiparasitic Agents Phase 4,Phase 3
20 Antiprotozoal Agents Phase 4,Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
22 Folic Acid Antagonists Phase 4,Phase 3
23 Renal Agents Phase 4,Phase 3,Phase 2
24 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
25 Vitamin B Complex Phase 4,Phase 3
26 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2
27 Lactams Phase 4
28 Folate Nutraceutical Phase 4,Phase 3
29 Vitamin B9 Nutraceutical Phase 4,Phase 3
30
Meropenem Approved, Investigational Phase 3 119478-56-7 441130 64778
31
Piperacillin Approved Phase 3,Phase 2 66258-76-2 43672
32
Tazobactam Approved Phase 3,Phase 2 89786-04-9 123630
33 Avibactam Approved Phase 3,Phase 2 1192500-31-4
34
Ceftazidime Approved Phase 3 72558-82-8, 78439-06-2 5481173
35
Fosfomycin Approved Phase 2, Phase 3 23155-02-4 446987
36
Colistin Approved Phase 3 1066-17-7, 1264-72-8 5311054
37
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
38
Tigecycline Approved Phase 3 220620-09-7 5282044
39
Ceftibuten Approved, Investigational Phase 3 97519-39-6 5282242 5282241
40 Liver Extracts Phase 3
41 beta-Lactamase Inhibitors Phase 3,Phase 2
42 Penicillanic Acid Phase 3,Phase 2
43 Piperacillin, tazobactam drug combination Phase 3,Phase 2
44 Thienamycins Phase 3
45 Avibactam, ceftazidime drug combination Phase 3
46 Cephalosporins Phase 3,Phase 2
47 carnitine Nutraceutical Phase 3
48 Omega 3 Fatty Acid Nutraceutical Phase 3
49
Ertapenem Approved, Investigational Phase 2 153832-46-3 150610
50
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old Completed NCT00136656 Phase 4 antibiotic;antibiotics
2 A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
3 Treatment's Duration of Acute Uncomplicated Pyelonephritis Completed NCT00873626 Phase 4 levofloxacin, ciprofloxacin and ofloxacin (fluoroquinolones)
4 Febrile Urinary Tract Infection Randomized Short Treatment Trial Completed NCT00809913 Phase 4 short treatment (ciprofloxacin)
5 Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women Completed NCT01390623 Phase 4 Ceftriaxone
6 Impact on the Intestinal Microbiota of Treatment With Ceftriaxone in Women's Acute Community Pyelonephritis Recruiting NCT03179384 Phase 4 Ceftriaxone
7 L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis Unknown status NCT02007889 Phase 3 L-carnitine
8 Oral Omega-3 for Reduction of Kidney Scar Due to Pyelonephritis in Children Unknown status NCT02192580 Phase 3 Omega-3
9 Contrast-Enhanced US of Spleen, Liver and Kidney Unknown status NCT00190281 Phase 3
10 Efficacy, Safety, Tolerability of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Complicated Urinary Tract Infections (cUTIs), Including Acute Pyelonephritis (AP), in Adults Completed NCT02166476 Phase 3 Meropenem-Vaborbactam;Piperacillin-Tazobactam;Levofloxacin;Saline
11 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01599806 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
12 Ceftazidime-Avibactam Compared With Doripenem Followed by Oral Therapy for Hospitalized Adults With Complicated UTIs (Urinary Tract Infections) Completed NCT01595438 Phase 3 Ceftazidime - Avibactam ( CAZ-AVI);Doripenem;Either switch to oral therapy: 500 mg of Ciprofloxacin (oral);or switch to oral therapy: 800 mg/160 mg of sulfamethoxazole/trimethoprim (oral)
13 A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP) Completed NCT02486627 Phase 3 plazomicin;meropenem;levofloxacin (oral)
14 A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis. Completed NCT00210886 Phase 3 levofloxacin
15 Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections Completed NCT02753946 Phase 2, Phase 3 ZTI-01;Piperacillin-tazobactam
16 Efficacy, Safety, Tolerability of Carbavance Compared to Best Available Therapy in Serious Infections Due to Carbapenem Resistant Enterobacteriaceae, in Adults Completed NCT02168946 Phase 3 Carbavance;Best Available Therapy
17 A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE) Completed NCT01970371 Phase 3 plazomicin;colistin;meropenem;tigecycline;antibiotic of Investigator's choice
18 Short-term Antibiotic Therapy for Pyelonephritis in Childhood Terminated NCT00724256 Phase 3 ceftibuten;ceftibuten
19 Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli Unknown status NCT02537847 Phase 2 Sitafloxacin;Ertapenem
20 Study of Plazomicin (ACHN-490) Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis Completed NCT01096849 Phase 2 levofloxacin;plazomicin;placebo
21 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
22 Finafloxacin for the Treatment of cUTI and/or Acute Pyelonephritis Completed NCT01928433 Phase 2 Finafloxacin 800 mg i.v. once daily;Finafloxacin placebo i.v. once daily;Finafloxacin 800 mg tablets once daily;Finafloxacin placebo tablets once daily;Ciprofloxacin 400 mg i.v. twice daily;Ciprofloxacin placebo i.v. twice daily;Ciprofloxacin 500 mg oral twice daily;Ciprofloxacin placebo oral twice daily
23 Comparative Study of Coadministered Ceftaroline Fosamil and NXL104 vs. Intravenous Doripenem in Adult Subjects With Complicated Urinary Tract Infections Completed NCT01281462 Phase 2 Ceftaroline fosamil and NXL104 (q8h);Ceftaroline fosamil and NXL104 (q12h);Doripenem;Placebo
24 Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections Recruiting NCT03445195 Phase 2 Sulbactam-ETX2514;Placebo;Imipenem-cilastatin
25 Prospective Study in the Emergency Terminated NCT01628900 Phase 2
26 GSK2251052 in Complicated Urinary Tract Infection Terminated NCT01381549 Phase 2 GSK2251052;imipenem-cilastatin
27 Proteinuria During Acute Pyelonephritis In Pregnancy Unknown status NCT02536638
28 Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection Unknown status NCT02034851
29 Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis Unknown status NCT00868270
30 Community-Associated Uropathogen Antimicrobial Resistance Among Emergency Department Patients With Acute Pyelonephritis Completed NCT01641029
31 Kinetics of Biomarkers in Acute Pyelonephritis Completed NCT00805181
32 Prospective Comparative Study About Treatment of Asymptomatic Bacteriuria in Kidney Transplant Recipients. Completed NCT02373085
33 Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae Completed NCT02420366
34 Incidence of Post Cystography Urinary Tract Infections in the Pediatric Population Recruiting NCT03399682
35 Efficacy and Pharmacokinetic/Pharmacodynamic Parameters of Cefoxitin in Women With Acute Pyelonephritis Without Severity Symptoms Due to Extended-spectrum β-lactamase Producing Escherichia Coli Terminated NCT01820793 Cefoxitin
36 Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis Withdrawn NCT01137929

Search NIH Clinical Center for Acute Pyelonephritis

Genetic Tests for Acute Pyelonephritis

Anatomical Context for Acute Pyelonephritis

MalaCards organs/tissues related to Acute Pyelonephritis:

38
Kidney, Liver, Neutrophil, Spleen, Testes, Colon, Prostate

Publications for Acute Pyelonephritis

Articles related to Acute Pyelonephritis:

(show top 50) (show all 624)
# Title Authors Year
1
Efficacy and Safety of Plazomicin Compared with Levofloxacin in the Treatment of Complicated Urinary Tract Infection and Acute Pyelonephritis: A Multicenter, Randomized, Double-Blind, Phase 2 Study. ( 29378708 )
2018
2
The use of cefepime as a carbapenem-sparing antibiotic for treating uncomplicated acute pyelonephritis caused by extended-spectrum I^-lactamase producing Escherichia coli. ( 29086602 )
2018
3
D-dimer as a marker of acute pyelonephritis in infants younger than 24A months with urinary tract infection. ( 29306986 )
2018
4
Acute Pyelonephritis in Adults. ( 29298155 )
2018
5
Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. ( 29065405 )
2018
6
Renal vein thrombosis complicating severe acute pyelonephritis with renal abscesses and associated bacteraemia caused by extended-spectrum beta-lactamase producing Escherichia coli. ( 29327131 )
2018
7
Overuse of Diagnostic Testing in the Management of Korean Patients with Acute Pyelonephritis. ( 28332347 )
2017
8
The climate impact on female acute pyelonephritis in Taiwan: AA population-based study. ( 28805597 )
2017
9
C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli. ( 29263309 )
2017
10
Role of piperacillin/tazobactam as a carbapenem-sparing antibiotic for treatment of acute pyelonephritis due to extended-spectrum I^-lactamase-producing Escherichia coli. ( 28263710 )
2017
11
Follow-up of acute pyelonephritis: what causes the diffusion-weighted magnetic resonance imaging recovery to lag clinical recovery? ( 28660334 )
2017
12
Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients. ( 27889429 )
2017
13
Splenic Abscess After Acute Pyelonephritis. ( 28215950 )
2017
14
Prevention of Renal Scarring in Acute Pyelonephritis by Probiotic Therapy: an Experimental Study. ( 29204797 )
2017
15
Ultrasonography of acute flank pain: a focus on renal stones and acute pyelonephritis. ( 29382187 )
2017
16
A randomized controlled trial of sitafloxacin vs. ertapenem as a switchA therapy after treatment for acute pyelonephritis caused by extended-spectrum I^-lactamase-producing Escherichia coli: A pilot study. ( 28587974 )
2017
17
Electrolyte and Acid-Base Abnormalities in Infants with Community-Acquired Acute Pyelonephritis: Prospective Cross-Sectional Study. ( 28697495 )
2017
18
18F-FDG PET/CT in Renal Infections: Evidence of Acute Pyelonephritis in a Horseshoe Kidney. ( 27879491 )
2017
19
Performance of qSOFA and SOFA for predicting mortality in patients with acute pyelonephritis associated with upper urinary tract calculi. ( 29291417 )
2017
20
Exploring the Anti-quorum Sensing and Antibiofilm Efficacy of Phytol against<i>Serratia marcescens</i>Associated Acute Pyelonephritis Infection in Wistar Rats. ( 29259923 )
2017
21
Corticosteroids for renal scar prevention in children with acute pyelonephritis. ( 28404702 )
2017
22
Role of antioxidant defence, renal toxicity markers and inflammatory cascade in disease progression of acute pyelonephritis in experimental rat model. ( 28578087 )
2017
23
Qualitative and quantitative radiological analysis of non-contrast CT is a strong indicator in patients with acute pyelonephritis. ( 29055617 )
2017
24
Eliciting renal tenderness by sonopalpation in diagnosing acute pyelonephritis. ( 28050884 )
2017
25
Serial sonographic findings during progression from acute pyelonephritis to renal abscess: a rare case report. ( 28509119 )
2017
26
Usefulness of Blood Cultures and Radiologic Imaging Studies in the Management of Patients with Community-Acquired Acute Pyelonephritis. ( 28271650 )
2017
27
A Cohort Study of Risk Factors That Influence Empirical Treatment of Patients with Acute Pyelonephritis. ( 28971876 )
2017
28
The role of nonautologous and autologous adipose-derived mesenchymal stem cell in acute pyelonephritis. ( 29218427 )
2017
29
Imaging technologies in the diagnosis and treatment of acute pyelonephritis. ( 28525662 )
2017
30
Treatment of complicated urinary tract infection and acute pyelonephritis by short-course intravenous levofloxacin (750A mg/day) or conventional intravenous/oral levofloxacin (500A mg/day): prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial. ( 28108978 )
2017
31
Transition Hand-Off from Inpatient to Outpatient Treatment of Acute Pyelonephritis in an Elderly Male. ( 28376986 )
2017
32
Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis. ( 28507449 )
2017
33
Distinctive inflammatory profile between acute focal bacterial nephritis and acute pyelonephritis in children. ( 28683358 )
2017
34
Neuroinvasive Infection from O117:K52:H-<i>Escherichia coli</i>following Acute Pyelonephritis. ( 29318066 )
2017
35
Acute Pyelonephritis - Correlation of Clinical Parameter with Radiological Imaging Abnormalities. ( 28764263 )
2017
36
Acute Pyelonephritis with Bacteremia Caused by Enterococcus hirae: A Rare Infection in Humans. ( 27127665 )
2016
37
Author's reply to the letter to the editor regarding "Hemoglobin level is a more predictive diagnostic marker for acute pyelonephritis than mean platelet volume". ( 27116249 )
2016
38
Use of cefuroxime for women with community-onset acute pyelonephritis caused by cefuroxime-susceptible or -resistant Escherichia coli. ( 26767868 )
2016
39
The combination of urinary IL - 6 and renal biometry as useful diagnostic tools to differentiate acute pyelonephritis from lower urinary tract infection. ( 27564295 )
2016
40
Outpatient treatment in women with acute pyelonephritis after visiting emergency department. ( 27534596 )
2016
41
Exploiting the antivirulence efficacy of an ajoene-ciprofloxacin combination against Pseudomonas aeruginosa biofilm associated murine acute pyelonephritis. ( 26930141 )
2016
42
Renal tuberculosis presenting as acute pyelonephritis - A rarity. ( 27865246 )
2016
43
Urachal abscess precipitated as acute pyelonephritis in an adult patient with diabetes. ( 26813570 )
2016
44
Hemoglobin level is a more predictive diagnostic marker for acute pyelonephritis than mean platelet volume. ( 26868147 )
2016
45
Acute pyelonephritis in transplanted kidneys: can diffusion-weighted magnetic resonance imaging be useful for diagnosis and follow-up? ( 27039324 )
2016
46
Diagnostic performance of initial serum lactate for predicting bacteremia in female patients with acute pyelonephritis. ( 27133532 )
2016
47
Plasma neutrophil gelatinase-associated lipocalin: a marker of acute pyelonephritis in children. ( 27744618 )
2016
48
Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population-Based Case-Control Study in Taiwan. ( 27539679 )
2016
49
Recurrent obstructive acute pyelonephritis: A rare form of Actinobaculum schaalii infection in a HIV-1 infected patient. ( 27940245 )
2016
50
A Case of Acute Pyelonephritis in Bilateral Renal Malrotation. ( 27689034 )
2016

Variations for Acute Pyelonephritis

Expression for Acute Pyelonephritis

Search GEO for disease gene expression data for Acute Pyelonephritis.

Pathways for Acute Pyelonephritis

Pathways related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
2
Show member pathways
13.01 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
3
Show member pathways
12.76 CXCL10 CXCL8 CXCR1 CXCR2 IL10 IL6
4
Show member pathways
12.29 CXCL10 CXCL8 IL10 IL6
5
Show member pathways
11.98 CXCL10 CXCL8 IL6
6
Show member pathways
11.97 CXCL10 CXCL8 CXCR1 CXCR2
7 11.96 CXCL8 IL10 IL6
8
Show member pathways
11.94 CXCL8 IL10 IL6
9 11.79 CXCL10 CXCL8 IL6
10 11.76 CXCL8 IL10 IL6
11 11.67 CXCL8 IL10 IL6
12
Show member pathways
11.62 CXCL10 CXCL8 CXCR1 CXCR2
13 11.53 CXCL8 IL10 IL6
14 11.32 CXCL8 CXCR1 IL6
15 11.27 CXCL8 IL10 IL6
16 11.07 IL10 IL6
17 10.9 CXCL10 CXCL8 IL10 IL6
18 10.76 CXCL10 CXCL8 IL10 IL6 PGF
19 10.61 CXCL10 CXCL8 IL10 IL6
20 10.41 CRP CXCL8 IL6

GO Terms for Acute Pyelonephritis

Cellular components related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ADM ALB CRP CXCL10 CXCL8 IL10
2 extracellular space GO:0005615 9.23 ADM ALB CRP CXCL10 CXCL8 IL10

Biological processes related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 ALB CXCR2 IL10 IL6
2 immune response GO:0006955 9.9 CXCL10 CXCL8 IL10 IL6
3 negative regulation of cell proliferation GO:0008285 9.89 ADM CXCL8 IL10 IL6
4 positive regulation of cell proliferation GO:0008284 9.85 ADM CXCL10 CXCR2 IL6 PGF
5 cell-cell signaling GO:0007267 9.83 ADM CXCL10 IL10 PGF
6 response to lipopolysaccharide GO:0032496 9.79 ADM CXCL10 IL10
7 chemotaxis GO:0006935 9.73 CXCL10 CXCL8 CXCR1 CXCR2
8 positive regulation of angiogenesis GO:0045766 9.67 ADM CXCL8 CXCR2 PGF
9 response to glucocorticoid GO:0051384 9.65 ADM IL10 IL6
10 regulation of receptor activity GO:0010469 9.63 ADM CXCL10 CXCL8 IL10 IL6 PGF
11 positive regulation of neutrophil chemotaxis GO:0090023 9.62 CXCL8 CXCR2
12 cellular response to lipopolysaccharide GO:0071222 9.62 CXCL10 CXCL8 IL10 IL6
13 dendritic cell chemotaxis GO:0002407 9.58 CXCR1 CXCR2
14 induction of positive chemotaxis GO:0050930 9.58 CXCL8 PGF
15 positive regulation of leukocyte chemotaxis GO:0002690 9.57 CXCR2 IL6
16 positive regulation of cAMP metabolic process GO:0030816 9.56 ADM CXCL10
17 chemokine-mediated signaling pathway GO:0070098 9.56 CXCL10 CXCL8 CXCR1 CXCR2
18 response to molecule of bacterial origin GO:0002237 9.55 CXCL8 IL10
19 neutrophil activation GO:0042119 9.54 CXCL8 CXCR2
20 negative regulation of lipid storage GO:0010888 9.51 CRP IL6
21 branching involved in labyrinthine layer morphogenesis GO:0060670 9.49 ADM IL10
22 interleukin-8-mediated signaling pathway GO:0038112 9.4 CXCR1 CXCR2
23 receptor internalization GO:0031623 9.26 ADM CXCL8 CXCR1 CXCR2
24 inflammatory response GO:0006954 9.17 CRP CXCL10 CXCL8 CXCR1 CXCR2 IL10

Molecular functions related to Acute Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.54 IL10 IL6 PGF
2 cytokine activity GO:0005125 9.46 CXCL10 CXCL8 IL10 IL6
3 chemokine receptor activity GO:0004950 9.32 CXCR1 CXCR2
4 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR1 CXCR2
5 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
6 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Acute Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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