MCID: ACT210
MIFTS: 56

Acute Respiratory Distress Syndrome

Categories: Rare diseases, Respiratory diseases, Cardiovascular diseases

Aliases & Classifications for Acute Respiratory Distress Syndrome

MalaCards integrated aliases for Acute Respiratory Distress Syndrome:

Name: Acute Respiratory Distress Syndrome 50
Respiratory Distress Syndrome, Adult 50 69
Non-Cardiogenic Pulmonary Edema 50 69
Acute Respiratory Distress 52 69
Acute Lung Injury 50 56
Increased-Permeability Pulmonary Edema 50
Adult Respiratory Distress Syndrome 50
Respiratory Distress Syndrome Adult 52
Shock Lung 50
Stiff Lung 50
Ards 50
Ali 50

Characteristics:

Orphanet epidemiological data:

56
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 56  
Rare respiratory diseases


External Ids:

Orphanet 56 ORPHA178320
MESH via Orphanet 43 D055371
UMLS via Orphanet 70 C0242488

Summaries for Acute Respiratory Distress Syndrome

NIH Rare Diseases : 50 acute respiratory distress syndrome (ards) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  people who develop ards often are very ill with another disease or have major injuries. the condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath. last updated: 5/17/2012

MalaCards based summary : Acute Respiratory Distress Syndrome, also known as respiratory distress syndrome, adult, is related to cauda equina syndrome and malaria, and has symptoms including cheyne-stokes respiration, coughing and dyspnea. An important gene associated with Acute Respiratory Distress Syndrome is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Toll Comparative Pathway. The drugs Curosurf and Infasurf have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and liver, and related phenotypes are immune system and liver/biliary system

Wikipedia : 72 Acute (or Adult) respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill... more...

Related Diseases for Acute Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Acute Respiratory Distress Syndrome Adult Acute Respiratory Distress Syndrome

Diseases related to Acute Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)
id Related Disease Score Top Affiliating Genes
1 cauda equina syndrome 30.1 LTA TNF
2 malaria 30.0 CXCL8 IL6 LTA THBD TNF
3 alcohol abuse 29.5 CXCL8 ELANE IL6 SFTPC TNF
4 adult acute respiratory distress syndrome 12.2
5 refsum disease 11.5
6 respiratory distress syndrome in premature infants 11.1
7 pulmonary fibrosis, idiopathic 11.0
8 bronchopulmonary dysplasia 10.9
9 staphylococcal toxic shock syndrome 10.9
10 pleural disease 10.8
11 aspiration pneumonitis 10.8
12 aicardi-goutieres syndrome 1, dominant and recessive 10.8
13 fructose intolerance, hereditary 10.8
14 al amyloidosis 10.8
15 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
16 oculomotor nerve paralysis 10.8 CXCL8 IL6
17 common peroneal nerve lesion 10.8 CXCL8 IL6
18 drug rash with eosinophilia and systemic symptoms 10.7 CXCL8 IL6
19 basidiobolomycosis 10.7 CXCL8 TNF
20 aortic arch interruption 10.7 IL6 TNF
21 cutaneous leishmaniasis 10.7 IL6 TNF
22 schwannoma of ureter 10.7 CXCL8 IL6
23 psychotic disorder 10.7 CXCL8 IL6
24 dyslexia 5 10.7 IL6 TNF
25 lymphangiectasia, intestinal 10.7 CXCL8 ELANE
26 epstein-barr virus hepatitis 10.7 IL6 TNF
27 scrotal carcinoma 10.7 IL6 TNF
28 anencephaly and spina bifida x-linked 10.6 IL6 TNF
29 enterovesical fistula 10.6 CXCL8 PI3
30 antigen-peptide-transporter 2 deficiency 10.6 IL6 TNF
31 bullous pemphigoid 10.6 ELANE PI3
32 infancy electroclinical syndrome 10.6 CXCL8 IL6
33 placenta praevia 10.6 ELANE PI3
34 cardiocranial syndrome 10.6 CXCL8 ELANE
35 labyrinthine bilateral reactive loss 10.6 CXCL8 ELANE IL6
36 papilledema 10.6 IL6 TNF
37 spondylocostal dysostosis 4 10.6 LTA TNF
38 ethmoid sinus adenocarcinoma 10.6 IL6 TNF
39 type 1 papillary adenoma of the kidney 10.6 LTA TNF
40 tarsal tunnel syndrome 10.6 CXCL8 TNF
41 cicatricial lagophthalmos 10.6 CXCL8 IL6 TNF
42 tricho onychic dysplasia 10.6 CXCL8 IL6 TNF
43 halal setton wang syndrome 10.5 CXCL8 TNF
44 burns 10.5 CXCL8 ELANE SFTPB
45 acquired thrombocytopenia 10.5 CXCL8 IL6 TNF
46 dysphagia 10.5 CXCL8 IL6 TNF
47 ovarian mucinous adenofibroma 10.5 CXCL8 IL6 TNF
48 spontaneous ocular nystagmus 10.5 CXCL8 ELANE TNF
49 esophagus leiomyoma 10.5 CXCL8 IL6 TNF
50 palmoplantar keratosis 10.5 CXCL8 IL6 TNF

Graphical network of the top 20 diseases related to Acute Respiratory Distress Syndrome:



Diseases related to Acute Respiratory Distress Syndrome

Symptoms & Phenotypes for Acute Respiratory Distress Syndrome

UMLS symptoms related to Acute Respiratory Distress Syndrome:


cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness, respiratory distress, labored breathing

MGI Mouse Phenotypes related to Acute Respiratory Distress Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.91 IL6 LBP LTA PLA2G7 SFTPC SFTPD
2 liver/biliary system MP:0005370 9.63 F5 IL6 LBP LTA THBD TNF
3 mortality/aging MP:0010768 9.61 ELANE F5 IL6 LTA SFTPB SFTPC
4 respiratory system MP:0005388 9.17 IL6 LTA SFTPB SFTPC SFTPD THBD

Drugs & Therapeutics for Acute Respiratory Distress Syndrome

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Curosurf 17 PORACTANT ALFA Dey Laboratories October 1998
2
Infasurf 17 CALFACTANT ONY July 1998

Drugs for Acute Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 393)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
2
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
3 Racepinephrine Approved Phase 4,Phase 2
4
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
5
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
6
Remifentanil Approved Phase 4 132875-61-7 60815
7 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1 108778-82-1
8
Budesonide Approved Phase 4,Phase 2 51333-22-3 63006 5281004
9 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
12
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
13
Clonidine Approved Phase 4 4205-90-7 2803
14
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
15
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
16
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
17
Thrombin Approved Phase 4
18
Carbon monoxide Approved Phase 4,Phase 1 630-08-0 281
19
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
20
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
21
Desflurane Approved Phase 4 57041-67-5 42113
22
Ketamine Approved, Vet_approved Phase 4,Phase 3 6740-88-1 3821
23
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
24
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
25 Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
26
Metformin Approved Phase 4 657-24-9 14219 4091
27
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
28
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
29
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
30
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
32
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
34
Misoprostol Approved Phase 4 59122-46-2 5282381
35 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
36
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
37 Cisatracurium Experimental Phase 4,Phase 3 96946-41-7
38
Butyric Acid Experimental Phase 4,Phase 3,Phase 2 107-92-6 264
39 Nefopam Investigational Phase 4 13669-70-0
40 Sivelestat Investigational Phase 4,Phase 1,Phase 2 127373-66-4
41 Neuromuscular Agents Phase 4,Phase 1,Phase 2
42 Neuromuscular Blocking Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
44 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
45 Cortisol succinate Phase 4,Phase 3,Phase 2
46 Epinephryl borate Phase 4,Phase 2
47 glucocorticoids Phase 4,Phase 2,Phase 3
48 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
49 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1022)

id Name Status NCT ID Phase Drugs
1 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
2 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
3 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
4 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
5 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
6 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
7 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
8 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
9 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
10 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
11 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
12 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
13 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
14 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
15 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
16 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
17 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
18 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
19 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
20 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
21 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
22 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
23 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
24 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
25 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
26 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
27 INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery Completed NCT01020409 Phase 4
28 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
29 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
30 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
31 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
32 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
33 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
34 Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents Completed NCT02168751 Phase 4 propofol;Sevoflurane
35 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
36 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
37 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
38 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
39 Recruitment Maneuver After Intubation Completed NCT01014299 Phase 4
40 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
41 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
42 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
43 Corticosteroid Mediates Acute Respiratory Distress Syndrome Recruiting NCT02819453 Phase 4 Dexamethasone
44 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4 Dexamethasone
45 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4 4% albumin
46 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4 remifentanil
47 Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Recruiting NCT02774317 Phase 4
48 Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation Recruiting NCT02962999 Phase 4 Ketamine;Saline
49 Early Non-invasive Ventilation Outside the Intensive Care Unit Recruiting NCT01572337 Phase 4
50 Handling Oxygenation Targets in the Intensive Care Unit Recruiting NCT03174002 Phase 4 Oxygen;Oxygen

Search NIH Clinical Center for Acute Respiratory Distress Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Acute Respiratory Distress Syndrome

Anatomical Context for Acute Respiratory Distress Syndrome

MalaCards organs/tissues related to Acute Respiratory Distress Syndrome:

39
Lung, Brain, Liver, Fetal Lung, Testes, Cervix, Neutrophil

Publications for Acute Respiratory Distress Syndrome

Articles related to Acute Respiratory Distress Syndrome:

(show top 50) (show all 498)
id Title Authors Year
1
Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome. ( 28035861 )
2017
2
A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema. ( 28841896 )
2017
3
'Lung-protective' ventilation in acute respiratory distress syndrome: still a challenge? ( 28932514 )
2017
4
Legionella pneumonia associated with severe acute respiratory distress syndrome and diffuse alveolar hemorrhage - A rare association. ( 28348947 )
2017
5
Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates. ( 28947918 )
2017
6
Obesity and survival in critically ill patients with acute respiratory distress syndrome: a paradox within the paradox. ( 28532465 )
2017
7
Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques. ( 28062701 )
2017
8
Return to work and lost earnings after acute respiratory distress syndrome: a 5-year prospective, longitudinal study of long-term survivors. ( 28918401 )
2017
9
Extracorporeal membrane oxygenation in spina bifida and (H1N1)-induced acute respiratory distress syndrome. ( 28905112 )
2017
10
Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome. ( 27543902 )
2017
11
Viral Pneumonia and Acute Respiratory Distress Syndrome. ( 28159154 )
2017
12
Pathophysiology and Management of Acute Respiratory Distress Syndrome in Children. ( 28941533 )
2017
13
Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms. ( 28070694 )
2017
14
Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors. ( 28067712 )
2017
15
Fatal Unusual Miliary Tuberculosis in which a Patient Developed Acute Respiratory Distress Syndrome Induced by Infliximab: An Autopsy Case Report. ( 28458316 )
2017
16
Disseminated herpes zoster causing acute respiratory distress syndrome in an immunocompetent patient. ( 28942398 )
2017
17
Enterovirus-Human Rhinovirus: A Rare Cause of Acute Respiratory Distress Syndrome. ( 28904980 )
2017
18
Primary Outcomes in Acute Respiratory Distress Syndrome Research. ( 28915191 )
2017
19
Intravascular large B-cell lymphoma as a cause of terminal acute respiratory distress syndrome: atypical presentation of a rare disease. ( 28444517 )
2017
20
A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline. ( 27768389 )
2017
21
Long-Term Pulmonary Function and Quality of Life in Children After Acute Respiratory Distress Syndrome: A Feasibility Investigation. ( 28060170 )
2017
22
Variability in Usual Care Mechanical Ventilation for Pediatric Acute Respiratory Distress Syndrome: Time for a Decision Support Protocol? ( 28930815 )
2017
23
Use of immunoproteomics to identify immunogenic proteins in a rat model of acute respiratory distress syndrome. ( 28944852 )
2017
24
Sepsis and acute respiratory distress syndrome requiring extracorporeal life support in an adolescent with mild cystic fibrosis. ( 28948140 )
2017
25
Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis. ( 28928799 )
2017
26
Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome. ( 28936695 )
2017
27
50 Years of Research in ARDS. Tidal Volume Selection in the Acute Respiratory Distress Syndrome. ( 28930639 )
2017
28
Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome. ( 28947844 )
2017
29
Recent Directions in Personalised Acute Respiratory Distress Syndrome Medicine. ( 28935455 )
2017
30
High-Frequency Oscillation in Acute Respiratory Distress Syndrome. The End of the Story? ( 28914571 )
2017
31
CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats. ( 28046003 )
2017
32
Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial. ( 28750677 )
2017
33
The Bumpy Road for Noninvasive Ventilation in Acute Respiratory Distress Syndrome. Coming to an End? ( 28035848 )
2017
34
Incidence Proportion of Acute Cor Pulmonale in Patients with Acute Respiratory Distress Syndrome Subjected to Lung Protective Ventilation: A Systematic Review and Meta-analysis. ( 28701843 )
2017
35
Novel swine model of ricin-induced acute respiratory distress syndrome. ( 28067630 )
2017
36
Noninvasive ventilation during acute respiratory distress syndrome in patients with cancer-what really matters. ( 28932510 )
2017
37
Use of corticosteroids in acute respiratory distress syndrome: Perspective from an Indian intensive care unit. ( 28924310 )
2017
38
Effect of setting high APRV guided by expiratory inflection point of pressure-volume curve on oxygen delivery in canine models of severe acute respiratory distress syndrome. ( 27588065 )
2016
39
Clinical predictors of hospital mortality differ between direct and indirect acute respiratory distress syndrome. ( 27663180 )
2016
40
Perceived safety and efficacy of neuromuscular blockers for acute respiratory distress syndrome among medical intensive care unit practitioners: A multicenter survey. ( 28012426 )
2016
41
Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review. ( 27152255 )
2016
42
A mortality score for acute respiratory distress syndrome: predicting the future without a crystal ball. ( 27618932 )
2016
43
Trials and Tribulations of Therapies for the Acute Respiratory Distress Syndrome. ( 27182881 )
2016
44
Pulmonary Vascular Dysfunction and Cor Pulmonale During Acute Respiratory Distress Syndrome in Sicklers. ( 27206275 )
2016
45
Association of rosuvastatin and delirium in severe sepsis with acute respiratory distress syndrome. ( 27618838 )
2016
46
Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome. ( 27706723 )
2016
47
Mass Spectrometry-based Proteomics in Acute Respiratory Distress Syndrome: A Powerful Modality for Pulmonary Precision Medicine. ( 27647196 )
2016
48
Fifty Years of Research in ARDS. Is Acute Respiratory Distress Syndrome a Preventable Disease? ( 28040987 )
2016
49
End-Expiratory Lung Volume in Patients with Acute Respiratory Distress Syndrome: A Time Course Analysis. ( 27169535 )
2016
50
On the complexity of scoring acute respiratory distress syndrome: do not forget hemodynamics! ( 27618840 )
2016

Variations for Acute Respiratory Distress Syndrome

Expression for Acute Respiratory Distress Syndrome

Search GEO for disease gene expression data for Acute Respiratory Distress Syndrome.

Pathways for Acute Respiratory Distress Syndrome

Pathways related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 CXCL8 IL6 LBP SFTPD TNF
2
Show member pathways
12.07 CXCL8 IL6 LBP TNF
3
Show member pathways
11.91 CXCL8 IL6 LTA TNF
4 11.9 CXCL8 IL6 TNF
5 11.85 IL6 LTA TNF
6
Show member pathways
11.84 IL6 LTA TNF
7 11.79 CXCL8 IL6 TNF
8
Show member pathways
11.78 SFTPB SFTPC SFTPD
9
Show member pathways
11.76 CXCL8 IL6 LBP
10 11.74 CXCL8 IL6 TNF
11 11.73 CXCL8 IL6 LBP TNF
12 11.72 CXCL8 IL6 LBP
13 11.66 CXCL8 IL6 TNF
14 11.65 IL6 THBD TNF
15 11.62 CXCL8 IL6 THBD TNF
16 11.61 IL6 LTA TNF
17
Show member pathways
11.55 CXCL8 IL6 TNF
18 11.54 CXCL8 LBP LTA TNF
19 11.48 CXCL8 IL6 TNF
20 11.47 LBP LTA TNF
21 11.39 CXCL8 IL6 TNF
22 11.38 CXCL8 IL6 TNF
23 11.35 ELANE IL6 TNF
24
Show member pathways
11.27 SFTPB SFTPC SFTPD
25
Show member pathways
11.24 CXCL8 IL6 LBP SFTPD TNF
26 11.14 CXCL8 IL6 THBD
27 11.07 CXCL8 IL6 LTA TNF
28 11.06 CXCL8 IL6 SFTPC TNF
29 11.03 CXCL8 TNF
30 10.99 IL6 TNF
31 10.61 CXCL8 IL6 TNF

GO Terms for Acute Respiratory Distress Syndrome

Cellular components related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CXCL8 ELANE F5 IL6 LBP LTA
2 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPB SFTPC SFTPD
3 extracellular space GO:0005615 9.4 CXCL8 ELANE F5 IL6 LBP LTA
4 lamellar body GO:0042599 9.33 SFTPB SFTPC SFTPD
5 multivesicular body lumen GO:0097486 9.32 SFTPB SFTPC

Biological processes related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.84 ELANE LBP SFTPD TNF
2 cellular response to lipopolysaccharide GO:0071222 9.71 CXCL8 IL6 LBP TNF
3 positive regulation of smooth muscle cell proliferation GO:0048661 9.7 ELANE IL6 TNF
4 humoral immune response GO:0006959 9.69 IL6 LTA TNF
5 positive regulation of interleukin-6 production GO:0032755 9.67 IL6 LBP TNF
6 defense response to Gram-positive bacterium GO:0050830 9.62 IL6 LBP LTA TNF
7 respiratory gaseous exchange GO:0007585 9.61 SFTPB SFTPC SFTPD
8 embryonic digestive tract development GO:0048566 9.58 CXCL8 TNF
9 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
10 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.57 ELANE TNF
11 response to yeast GO:0001878 9.56 ELANE IL6
12 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.55 IL6 TNF
13 cellular protein metabolic process GO:0044267 9.55 F5 IL6 SFTPB SFTPC SFTPD
14 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.48 LTA TNF
15 negative regulation of chemokine biosynthetic process GO:0045079 9.46 ELANE IL6
16 positive regulation of chemokine production GO:0032722 9.43 IL6 LBP TNF
17 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.37 LTA TNF
18 response to lipopolysaccharide GO:0032496 9.35 ELANE IL6 LBP LTA THBD
19 negative regulation of growth of symbiont in host GO:0044130 8.92 ELANE LBP LTA TNF

Molecular functions related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL6 LTA TNF

Sources for Acute Respiratory Distress Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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