MCID: ACT210
MIFTS: 63

Acute Respiratory Distress Syndrome

Categories: Rare diseases, Respiratory diseases, Cardiovascular diseases

Aliases & Classifications for Acute Respiratory Distress Syndrome

MalaCards integrated aliases for Acute Respiratory Distress Syndrome:

Name: Acute Respiratory Distress Syndrome 49
Respiratory Distress Syndrome, Adult 49 69
Non-Cardiogenic Pulmonary Edema 49 69
Acute Respiratory Distress 51 69
Acute Lung Injury 49 55
Increased-Permeability Pulmonary Edema 49
Adult Respiratory Distress Syndrome 49
Shock Lung 49
Stiff Lung 49
Ards 49
Ali 49

Characteristics:

Orphanet epidemiological data:

55
acute lung injury
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 55  
Rare respiratory diseases


External Ids:

Orphanet 55 ORPHA178320
MESH via Orphanet 42 D055371
UMLS via Orphanet 70 C0242488

Summaries for Acute Respiratory Distress Syndrome

NIH Rare Diseases : 49 Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood.  People who develop ARDS often are very ill with another disease or have major injuries. The condition leads to a buildup of fluid in the air sacs which prevents enough oxygen from passing into the bloodstream. Symptoms may include difficulty breathing, low blood pressure and organ failure, rapid breathing and shortness of breath. Last updated: 5/17/2012

MalaCards based summary : Acute Respiratory Distress Syndrome, also known as respiratory distress syndrome, adult, is related to respiratory distress syndrome in premature infants and staphylococcal toxic shock syndrome, and has symptoms including labored breathing, respiratory distress and hoarseness. An important gene associated with Acute Respiratory Distress Syndrome is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Curosurf and Infasurf have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and liver, and related phenotypes are immune system and mortality/aging

Wikipedia : 72 Acute respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill patients... more...

Related Diseases for Acute Respiratory Distress Syndrome

Diseases in the Adult Respiratory Distress Syndrome family:

Acute Respiratory Distress Syndrome Adult Acute Respiratory Distress Syndrome

Diseases related to Acute Respiratory Distress Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 371)
# Related Disease Score Top Affiliating Genes
1 respiratory distress syndrome in premature infants 32.3 SFTPB SFTPC
2 staphylococcal toxic shock syndrome 32.2 IL1B TNF
3 bronchopulmonary dysplasia 32.0 CXCL8 ELANE SFTPB
4 adult respiratory distress syndrome 31.6 CXCL8 ELANE IL6 SFTPC TNF
5 peritonitis 31.6 CXCL8 IL1B IL6 TNF
6 pulmonary edema 30.7 CXCL8 IL1B TNF
7 pustular psoriasis 30.4 ELANE PI3 TNF
8 bronchiolitis obliterans 30.4 CXCL8 IL6 TNF
9 bronchiolitis 30.3 CXCL8 IL6 TNF
10 esophagitis 30.2 CXCL8 IL1B IL6
11 adult-onset still's disease 30.2 IL1B IL6 TNF
12 acute pancreatitis 30.1 CXCL8 ELANE IL6
13 cytomegalovirus infection 30.0 CXCL8 IL6 TNF
14 bronchitis 30.0 CXCL8 ELANE TNF
15 brucellosis 30.0 CXCL8 IL6 TNF
16 dengue hemorrhagic fever 30.0 CXCL8 IL6 TNF
17 surfactant dysfunction 30.0 SFTPB SFTPC
18 sleep apnea 30.0 CXCL8 IL6 TNF
19 malaria 29.9 CXCL8 IL1B IL6 LTA TNF
20 dengue shock syndrome 29.9 IL1B IL6 TNF
21 leptospirosis 29.9 CXCL8 IL1B IL6 TNF
22 pulmonary disease, chronic obstructive 29.8 CXCL8 ELANE IL6 TNF
23 wegener granulomatosis 29.8 CXCL8 ELANE IL6 TNF
24 meningitis 29.7 CXCL8 IL1B IL6 TNF
25 rheumatoid arthritis 29.6 CXCL8 IL1B IL6 TNF
26 arthritis 29.5 CXCL8 IL1B IL6 LTA TNF
27 avian influenza 29.4 CXCL8 IL6 SFTPD TNF
28 pulmonary fibrosis 29.0 IL1B SFTPC SFTPD
29 psoriasis 28.9 CXCL8 ELANE IL1B IL6 LTA PI3
30 pneumonia 28.6 CXCL8 ELANE IL1B IL6 SFTPB SFTPC
31 respiratory failure 28.5 CXCL8 ELANE SFTPB SFTPC SFTPD TNF
32 pulmonary fibrosis, idiopathic 27.9 CXCL8 ELANE IL1B SFTPB SFTPC SFTPD
33 interstitial lung disease 27.8 CXCL8 IL1B IL6 SFTPB SFTPC SFTPD
34 lung disease 27.4 CXCL8 ELANE IL1B PI3 SFTPB SFTPC
35 adult acute respiratory distress syndrome 12.4
36 aicardi-goutieres syndrome 1 10.9
37 fructose intolerance, hereditary 10.9
38 al amyloidosis 10.9
39 scorpion envenomation 10.5 IL6 TNF
40 acute transverse myelitis 10.5 CXCL8 IL6
41 felty syndrome 10.5 CXCL8 ELANE
42 tungiasis 10.5 CXCL8 TNF
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
44 critical limb ischemia 10.5 IL6 TNF
45 denture stomatitis 10.5 CXCL8 IL6
46 papillary conjunctivitis 10.4 CXCL8 IL6
47 polyposis, gastric 10.4 IL1B TNF
48 cardiac rupture 10.4 CXCL8 ELANE
49 periodontitis, chronic 10.4 IL1B IL6
50 retinitis pigmentosa 55 10.4 IL6 TNF

Graphical network of the top 20 diseases related to Acute Respiratory Distress Syndrome:



Diseases related to Acute Respiratory Distress Syndrome

Symptoms & Phenotypes for Acute Respiratory Distress Syndrome

UMLS symptoms related to Acute Respiratory Distress Syndrome:


labored breathing, respiratory distress, hoarseness, hemoptysis, dyspnea, coughing, cheyne-stokes respiration, apnea

MGI Mouse Phenotypes related to Acute Respiratory Distress Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.86 TNF ELANE IL1B IL6 LTA PLA2G7
2 mortality/aging MP:0010768 9.85 ELANE F5 IL1B IL6 LTA PLA2G7
3 neoplasm MP:0002006 9.35 TNF ELANE IL1B IL6 SFTPC
4 respiratory system MP:0005388 9.1 TNF IL6 LTA SFTPB SFTPC SFTPD

Drugs & Therapeutics for Acute Respiratory Distress Syndrome

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Curosurf 17 PORACTANT ALFA Dey Laboratories October 1998
2
Infasurf 17 CALFACTANT ONY July 1998

Drugs for Acute Respiratory Distress Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 411)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 46507594 772
2
Clonidine Approved Phase 4 4205-90-7 2803
3
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
4
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
5
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
6
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
7
Metformin Approved Phase 4 657-24-9 4091 14219
8
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
9
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 657311 5754
10
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
11
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
12
Budesonide Approved Phase 4,Phase 2 51333-22-3 5281004 63006
13 Cisatracurium Approved, Experimental Phase 4,Phase 3 96946-41-7
14
Remifentanil Approved Phase 4 132875-61-7 60815
15
Ketamine Approved, Vet_approved Phase 4,Phase 3 6740-88-1 3821
16
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
17
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
18
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
19
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
20
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
21
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
22
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
23
Desflurane Approved Phase 4 57041-67-5 42113
24 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1 108778-82-1
25
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
26 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
27 Racepinephrine Approved Phase 4,Phase 2 329-65-7
28
Thrombin Approved, Investigational Phase 4
29
Carbon monoxide Approved, Investigational Phase 4,Phase 1 630-08-0 281
30 Nefopam Approved, Investigational Phase 4 13669-70-0
31
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
32
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
33
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
34
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
35
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
36
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
37
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
38
Misoprostol Approved Phase 4 59122-46-2 5282381
39 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
40
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
41
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
42
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
43
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
44
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 10883523 5280795 6221
45
B-Carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
46
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2 107-92-6 264
47 Sivelestat Investigational Phase 4,Phase 1,Phase 2 127373-66-4
48 calcium heparin Phase 4,Phase 2,Phase 3,Phase 1
49 Prednisolone acetate Phase 4,Phase 2,Phase 3
50 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5

Interventional clinical trials:

(show top 50) (show all 1076)

# Name Status NCT ID Phase Drugs
1 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
2 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
3 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
4 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
5 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
6 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
7 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
8 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
9 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
10 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
11 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
12 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
13 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
14 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
15 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
16 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
17 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
18 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
19 Corticosteroid Mediates Acute Respiratory Distress Syndrome Completed NCT02819453 Phase 4 Methylprednisolone
20 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
21 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
22 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
23 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
24 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
25 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
26 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
27 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
28 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
29 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
30 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
31 INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery Completed NCT01020409 Phase 4
32 Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management Completed NCT01710891 Phase 4
33 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
34 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
35 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach Completed NCT02135146 Phase 4 Plasmalyte 3ml/kg/hr group;Plasmalyte 6ml/kg/hr group
36 Inflammatory Response Secondary Using Intravenous Anesthesia Versus Inhalation Anesthesia With Halogenated Agents Completed NCT02168751 Phase 4 propofol;Sevoflurane
37 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
38 Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With AECOPD Completed NCT03333395 Phase 4 Nebulized heparin and salbutamol;Nebulized salbutamol
39 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
40 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
41 Recruitment Maneuver After Intubation Completed NCT01014299 Phase 4
42 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
43 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
44 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
45 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
46 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
47 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4 Dexamethasone
48 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4 4% albumin
49 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4 remifentanil
50 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone

Search NIH Clinical Center for Acute Respiratory Distress Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Acute Respiratory Distress Syndrome

Anatomical Context for Acute Respiratory Distress Syndrome

MalaCards organs/tissues related to Acute Respiratory Distress Syndrome:

38
Lung, Brain, Liver, Testes, Fetal Lung, Heart, Cervix

Publications for Acute Respiratory Distress Syndrome

Articles related to Acute Respiratory Distress Syndrome:

(show top 50) (show all 523)
# Title Authors Year
1
NF-I_B-Induced MicroRNA-211 Inhibits Interleukin-10 in Macrophages of Rats with Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. ( 29402831 )
2018
2
Pediatric acute respiratory distress syndrome - current views. ( 29434764 )
2018
3
Pediatric Acute Respiratory Distress Syndrome - Increase the PEEP? ( 29451804 )
2018
4
Antipsychotics, Delirium, and Acute Respiratory Distress Syndrome: What is the Link? ( 29444340 )
2018
5
The Randomized Educational Acute Respiratory Distress Syndrome Diagnosis Study: A Trial to Improve the Radiographic Diagnosis of Acute Respiratory Distress Syndrome. ( 29438110 )
2018
6
The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome. ( 29425776 )
2018
7
Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration. ( 29310581 )
2018
8
Unilateral Acute Respiratory Distress Syndrome with Contralateral Pulmonary Artery Agenesis. ( 29125306 )
2018
9
Diagnosis of acute respiratory distress syndrome by exhaled breath analysis. ( 29430450 )
2018
10
Heart-lung interactions in acute respiratory distress syndrome: pathophysiology, detection and management strategies. ( 29430444 )
2018
11
An Exploratory Reanalysis of the Randomized Trial on Efficacy of Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome. ( 29432350 )
2018
12
Effects of hypercapnia in acute respiratory distress syndrome. ( 29430454 )
2018
13
Genome Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor. ( 29425463 )
2018
14
Macrolide therapy is associated with reduced mortality in acute respiratory distress syndrome (ARDS) patients. ( 29430441 )
2018
15
The relationship between high-dose corticosteroid treatment and mortality in acute respiratory distress syndrome: a retrospective and observational study using a nationwide administrative database in Japan. ( 29415701 )
2018
16
Focal Encephalitis, Meningitis and Acute Respiratory Distress Syndrome Associated with Influenza A Infection. ( 29402867 )
2018
17
Anticoagulant therapy in acute respiratory distress syndrome. ( 29430453 )
2018
18
Novel complication of an emerging disease: Invasive<i>Klebsiella pneumoniae</i>liver abscess syndrome as a cause of acute respiratory distress syndrome. ( 29441188 )
2018
19
Is Overall Mortality the Right Composite Endpoint in Clinical Trials of Acute Respiratory Distress Syndrome? ( 29420341 )
2018
20
Characteristics of early acute respiratory distress syndrome in newly diagnosed acute myeloid leukemia. ( 29431568 )
2018
21
Obesity and survival in critically ill patients with acute respiratory distress syndrome: a paradox within the paradox. ( 28532465 )
2017
22
A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema. ( 28841896 )
2017
23
Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms. ( 28070694 )
2017
24
Enterovirus-Human Rhinovirus: A Rare Cause of Acute Respiratory Distress Syndrome. ( 28904980 )
2017
25
Efficacy study of pulmonary surfactant combined with assisted ventilation for acute respiratory distress syndrome management of term neonates. ( 28947918 )
2017
26
Novel swine model of ricin-induced acute respiratory distress syndrome. ( 28067630 )
2017
27
Sepsis and acute respiratory distress syndrome requiring extracorporeal life support in an adolescent with mild cystic fibrosis. ( 28948140 )
2017
28
Extracorporeal membrane oxygenation in spina bifida and (H1N1)-induced acute respiratory distress syndrome. ( 28905112 )
2017
29
Primary Outcomes in Acute Respiratory Distress Syndrome Research. ( 28915191 )
2017
30
CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats. ( 28046003 )
2017
31
50 Years of Research in ARDS. Tidal Volume Selection in the Acute Respiratory Distress Syndrome. ( 28930639 )
2017
32
A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline. ( 27768389 )
2017
33
Muscle Weakness and 5-Year Survival in Acute Respiratory Distress Syndrome Survivors. ( 28067712 )
2017
34
Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis. ( 28928799 )
2017
35
'Lung-protective' ventilation in acute respiratory distress syndrome: still a challenge? ( 28932514 )
2017
36
Intravascular large B-cell lymphoma as a cause of terminal acute respiratory distress syndrome: atypical presentation of a rare disease. ( 28444517 )
2017
37
Use of immunoproteomics to identify immunogenic proteins in a rat model of acute respiratory distress syndrome. ( 28944852 )
2017
38
Use of corticosteroids in acute respiratory distress syndrome: Perspective from an Indian intensive care unit. ( 28924310 )
2017
39
Recent Directions in Personalised Acute Respiratory Distress Syndrome Medicine. ( 28935455 )
2017
40
A Morphological and Quantitative Analysis of Lung CT Scan in Patients With Acute Respiratory Distress Syndrome and in Cardiogenic Pulmonary Edema. ( 29161936 )
2017
41
Return to work and lost earnings after acute respiratory distress syndrome: a 5-year prospective, longitudinal study of long-term survivors. ( 28918401 )
2017
42
Fatal Unusual Miliary Tuberculosis in which a Patient Developed Acute Respiratory Distress Syndrome Induced by Infliximab: An Autopsy Case Report. ( 28458316 )
2017
43
Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial. ( 28750677 )
2017
44
Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome. ( 27543902 )
2017
45
Pathophysiology and Management of Acute Respiratory Distress Syndrome in Children. ( 28941533 )
2017
46
Gastrointestinal tuberculosis following renal transplantation accompanied with septic shock and acute respiratory distress syndrome: a survival case presentation. ( 29179699 )
2017
47
Long-Term Pulmonary Function and Quality of Life in Children After Acute Respiratory Distress Syndrome: A Feasibility Investigation. ( 28060170 )
2017
48
High-Frequency Oscillation in Acute Respiratory Distress Syndrome. The End of the Story? ( 28914571 )
2017
49
Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome. ( 28947844 )
2017
50
Legionella pneumonia associated with severe acute respiratory distress syndrome and diffuse alveolar hemorrhage - A rare association. ( 28348947 )
2017

Variations for Acute Respiratory Distress Syndrome

Expression for Acute Respiratory Distress Syndrome

Search GEO for disease gene expression data for Acute Respiratory Distress Syndrome.

Pathways for Acute Respiratory Distress Syndrome

Pathways related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 CXCL8 IL1B IL6 LTA PLA2G7 TNF
2
Show member pathways
12.79 CXCL8 IL1B IL6 LTA TNF
3
Show member pathways
12.74 CXCL8 IL1B IL6 LTA TNF
4
Show member pathways
12.63 CXCL8 IL1B IL6 TNF
5
Show member pathways
12.61 IL1B IL6 LTA TNF
6
Show member pathways
12.47 CXCL8 IL1B IL6 TNF
7
Show member pathways
12.28 CXCL8 IL1B IL6 TNF
8
Show member pathways
12.22 CXCL8 IL1B IL6 TNF
9 12.14 CXCL8 IL1B IL6 TNF
10 11.96 CXCL8 IL1B IL6 TNF
11
Show member pathways
11.94 CXCL8 IL1B IL6 SFTPD TNF
12 11.93 CXCL8 IL1B IL6 TNF
13 11.89 CXCL8 IL1B IL6
14 11.89 IL1B IL6 LTA TNF
15
Show member pathways
11.87 IL1B IL6 LTA TNF
16 11.85 IL1B IL6 TNF
17
Show member pathways
11.84 SFTPB SFTPC SFTPD
18 11.83 CXCL8 IL1B IL6 TNF
19 11.81 CXCL8 IL1B IL6 TNF
20 11.79 CXCL8 IL1B IL6
21 11.79 CXCL8 IL1B LTA TNF
22 11.75 IL1B LTA TNF
23 11.73 CXCL8 IL1B IL6 TNF
24 11.71 IL1B IL6 TNF
25 11.65 IL6 LTA TNF
26 11.64 CXCL8 IL1B IL6 TNF
27
Show member pathways
11.56 CXCL8 IL1B IL6 LTA TNF
28
Show member pathways
11.53 CXCL8 IL1B IL6 TNF
29 11.5 ELANE IL6 TNF
30 11.47 IL1B IL6 TNF
31
Show member pathways
11.44 SFTPB SFTPC SFTPD
32 11.41 CXCL8 IL1B IL6 TNF
33 11.34 IL1B IL6 TNF
34 11.33 IL1B IL6 TNF
35 11.29 IL1B IL6 TNF
36 11.27 IL1B IL6 TNF
37 11.25 CXCL8 IL1B IL6 TNF
38 11.24 IL1B IL6 TNF
39
Show member pathways
11.15 SFTPB SFTPC SFTPD
40 11.15 CXCL8 IL1B IL6 TNF
41 11.11 IL1B PLA2G7
42 11.09 CXCL8 TNF
43 11.05 IL1B TNF
44 11.04 IL6 TNF
45 11.03 CXCL8 IL1B IL6 LTA TNF
46 10.96 CXCL8 IL1B IL6 LTA TNF
47 10.95 CXCL8 IL6 TNF
48 10.9 IL1B TNF
49 10.82 CXCL8 IL1B IL6 SFTPC TNF
50 10.77 IL1B IL6

GO Terms for Acute Respiratory Distress Syndrome

Cellular components related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CXCL8 ELANE F5 IL1B IL6 LTA
2 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPB SFTPC SFTPD
3 extracellular region GO:0005576 9.4 CXCL8 ELANE F5 IL1B IL6 LTA
4 lamellar body GO:0042599 9.33 SFTPB SFTPC SFTPD
5 multivesicular body lumen GO:0097486 9.32 SFTPB SFTPC

Biological processes related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CXCL8 IL1B IL6 TNF
2 immune response GO:0006955 9.92 CXCL8 IL1B IL6 LTA TNF
3 regulation of receptor activity GO:0010469 9.85 CXCL8 IL1B IL6 LTA TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL1B IL6 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL6 TNF
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.79 IL1B IL6 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.77 IL6 LTA TNF
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.73 ELANE IL6 TNF
9 humoral immune response GO:0006959 9.72 IL6 LTA TNF
10 positive regulation of NF-kappaB import into nucleus GO:0042346 9.65 IL1B TNF
11 positive regulation of chemokine production GO:0032722 9.65 IL6 TNF
12 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TNF
13 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
14 negative regulation of lipid catabolic process GO:0050995 9.64 IL1B TNF
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.62 IL1B TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL1B TNF
18 positive regulation of interferon-gamma production GO:0032729 9.61 IL1B LTA TNF
19 negative regulation of lipid storage GO:0010888 9.59 IL6 TNF
20 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
21 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 ELANE TNF
22 regulation of establishment of endothelial barrier GO:1903140 9.57 IL1B TNF
23 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
24 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
25 respiratory gaseous exchange GO:0007585 9.5 SFTPB SFTPC SFTPD
26 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.49 LTA TNF
27 positive regulation of phagocytosis GO:0050766 9.43 IL1B SFTPD TNF
28 negative regulation of chemokine biosynthetic process GO:0045079 9.4 ELANE IL6
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
30 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
31 negative regulation of growth of symbiont in host GO:0044130 9.13 ELANE LTA TNF
32 cellular protein metabolic process GO:0044267 9.02 F5 IL6 SFTPB SFTPC SFTPD

Molecular functions related to Acute Respiratory Distress Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL1B IL6 LTA TNF

Sources for Acute Respiratory Distress Syndrome

3 CDC
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70 UMLS via Orphanet
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