MCID: ACT020
MIFTS: 28

Acute T Cell Leukemia malady

Immune diseases, Cancer diseases, Skin diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Acute T Cell Leukemia

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Aliases & Descriptions for Acute T Cell Leukemia:

Name: Acute T Cell Leukemia 8 10
T-Cell Acute Lymphoblastic Leukemia 8 9
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 61
Precursor T-Cell Lymphoblastic Lymphoma 61
 
Leukemia, T-Cell Acute Lymphoblastic 9
Leukemia, Acute T-Cell Lymphoblastic 9
Precursor T Lymphoblastic Leukemia 8
Leukemia, Acute T-Cell 9


Classifications:



External Ids:

Disease Ontology8 DOID:5603
MeSH33 D015459
NCIt39 C3184

Summaries for Acute T Cell Leukemia

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MalaCards based summary: Acute T Cell Leukemia, also known as t-cell acute lymphoblastic leukemia, is related to precursor t-cell acute lymphoblastic leukemia and t-cell leukemia. An important gene associated with Acute T Cell Leukemia is HSD17B1 (hydroxysteroid (17-beta) dehydrogenase 1). Affiliated tissues include t cells and b cells.

Related Diseases for Acute T Cell Leukemia

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Graphical network of the top 20 diseases related to Acute T Cell Leukemia:



Diseases related to acute t cell leukemia

Symptoms for Acute T Cell Leukemia

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Drugs & Therapeutics for Acute T Cell Leukemia

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Arranon13 38 NELARABINE GlaxoSmithKline Approved October 2005
FDA Label: Arranon
Malady that Drug Treats: Lymphoblastic Leukemia
Indications and Usage:13 ARRANON is a nucleoside metabolic inhibitor indicated for the treatment of; patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic; lymphoma whose disease has not responded to or has relapsed following; treatment with at least two chemotherapy regimens. This use is based on the; induction of complete responses. Randomized trials demonstrating increased; survival or other clinical benefit have not been conducted. (1)
DrugBank Targets:11 DNA
Mechanism of Action:13 
Target: DNA synthesis
Action: disruptor --> apoptosis
FDA: Nelarabine is a pro-drug of the deoxyguanosine analogue 9-²-D-arabinofuranosylguanine; 266 (ara-G), a nucleoside metabolic inhibitor. Nelarabine is demethylated by adenosine deaminase; 267 (ADA) to ara-G, mono-phosphorylated by deoxyguanosine kinase and deoxycytidine kinase, and; 268 subsequently converted to the active 5 -triphosphate, ara-GTP. Accumulation of ara-GTP in; 269 leukemic blasts allows for incorporation into deoxyribonucleic acid (DNA), leading to inhibition; 270 of DNA synthesis and cell death. Other mechanisms may contribute to the cytotoxic and; 271 systemic toxicity of nelarabine.

Drug clinical trials:

Search ClinicalTrials for Acute T Cell Leukemia

Search NIH Clinical Center for Acute T Cell Leukemia

Genetic Tests for Acute T Cell Leukemia

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Anatomical Context for Acute T Cell Leukemia

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MalaCards organs/tissues related to Acute T Cell Leukemia:

31
T cells, B cells

Animal Models for Acute T Cell Leukemia or affiliated genes

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Publications for Acute T Cell Leukemia

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Articles related to Acute T Cell Leukemia:

(show all 24)
idTitleAuthorsYear
1
Mir-55 inhibition can reduce cell proliferation and induce apoptosis in Jurkat (Acute T cell Leukemia) cell line. (25598954)
2014
2
Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line: Prooxidative potential of hydroxylated resveratrol analogs. (24398169)
2014
3
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells. (24394624)
2014
4
Conversion of estrone to 17 beta-estradiol in Jurkat acute T cell leukemia Hut-78 T- and Raji B lymphoma cell lines in vitro. (23540283)
2013
5
Combined treatment with fenretinide and indomethacin induces AIF-mediated, non-classical cell death in human acute T-cell leukemia Jurkat cells. (22387538)
2012
6
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. (20008304)
2010
7
Complete regression of massive cardiac involvement associated with acute T cell leukemia following chemotheraphy. (17320483)
2008
8
Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias. (16502262)
2006
9
CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. (16332967)
2006
10
Post-transplantation lymphoproliferative disorder of recipient origin in a boy with acute T-cell leukemia with detection of B-cell clonality 3 months before stem cell transplantation. (16266918)
2005
11
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). (15774621)
2005
12
Denileukin diftitox and hyper-CVAD in the treatment of human T-cell lymphotropic virus 1-associated acute T-cell leukemia/lymphoma. (14715100)
2003
13
A novel post-transcriptional splicing form of the acute T cell leukemia proto-oncogene Lmo2. (18763096)
2001
14
Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (8545129)
1995
15
Successful treatment of human acute T-cell leukemia in SCID mice using the anti-CD7-deglycosylated ricin A-chain immunotoxin DA7. (1371092)
1992
16
Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion. (2208004)
1990
17
Antigen-specific recognition of autologous leukemia cells and allogeneic class-I MHC antigens by IL-2-activated cytotoxic T cells from a patient with acute T-cell leukemia. (2546621)
1989
18
Constitutive expression and abnormal glycosylation of transferrin receptor in acute T-cell leukemia. (2582441)
1989
19
A case of CD3+, CD4-, CD8-, WT31- acute T-cell leukemia. (2787596)
1989
20
Cyclosporine A and acute T cell leukemia in the rat. (3164536)
1988
21
Childhood primary cutaneous non-T/non-B lymphoma followed by acute T-cell leukemia. (3486034)
1986
22
T-lymphoblasts with erythropoietic helper function in acute T-cell leukemia. (2978965)
1986
23
t(11;19)(q23;p11) in a child with acute T-cell leukemia. (3855377)
1985
24
Human serum thymic factor in detecting acute T cell leukemia. (311636)
1978

Variations for Acute T Cell Leukemia

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Expression for genes affiliated with Acute T Cell Leukemia

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Search GEO for disease gene expression data for Acute T Cell Leukemia.

Pathways for genes affiliated with Acute T Cell Leukemia

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Compounds for genes affiliated with Acute T Cell Leukemia

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GO Terms for genes affiliated with Acute T Cell Leukemia

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Cellular components related to Acute T Cell Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00056679.1LMO4, LMO2

Molecular functions related to Acute T Cell Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:00082708.5LPP, LMO4, LMO2

Sources for Acute T Cell Leukemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet