MCID: ACT020
MIFTS: 43

Acute T Cell Leukemia malady

Immune diseases category

Summaries for Acute T Cell Leukemia

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46OMIM, 32MalaCards
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MalaCards: Acute T Cell Leukemia, also known as t-cell acute lymphoblastic leukemia, is related to acute leukemia and acute myeloid leukemia. An important gene associated with Acute T Cell Leukemia is LAP (Laryngeal adductor paralysis). The compounds 4-hydroxynonenal and flavonoid have been mentioned in the context of this disorder. Affiliated tissues include t cells, myeloid and b cells, and related mouse phenotype cellular.

Description from OMIM:46 613065

Aliases & Classifications for Acute T Cell Leukemia

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8Disease Ontology, 10DISEASES, 9diseasecard, 46OMIM, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

acute t cell leukemia 8 10
t-cell acute lymphoblastic leukemia 8 9 46
leukemia, t-cell acute lymphoblastic 9 46
leukemia, acute t-cell lymphoblastic 9 46
leukemia, acute t-cell 9 46
precursor t-cell lymphoblastic leukemia-lymphoma 60
precursor t lymphoblastic leukemia 8


External Ids:

Disease Ontology8 DOID:5603
MeSH34 D015459
NCIt39 C3184

Related Diseases for Acute T Cell Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia T-Cell Leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to Acute T Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.2MYB
2acute myeloid leukemia31.0PICALM, NUP214
3myeloid leukemia31.0MYB, BAX, PICALM
4precursor t-cell acute lymphoblastic leukemia30.7NUP214, MYB, BAX, PICALM
5cutaneous t cell lymphoma30.2BAX, MYB
6adult t-cell leukemia10.9
7leukemia10.8
8t-cell leukemia10.8
9lymphocytic leukemia, acute t-cell10.3
10acute pancreatitis10.3
11pure red-cell aplasia10.3
12hemophagocytic lymphohistiocytosis10.3
13juvenile xanthogranuloma10.3
14ataxia telangiectasia10.3
15juvenile myelomonocytic leukemia10.3
16adult lymphoma10.3
17anaplastic large cell lymphoma10.3
18small cell sarcoma10.3
19acute lymphocytic leukemia10.3
20aleukemic leukemia cutis10.3
21histiocytosis10.3
22hyperostosis10.3
23langerhans-cell histiocytosis10.3
24meningioma10.3
25neuroblastoma10.3
26pancreatitis10.3
27paraplegia10.3
28pericardial effusion10.3
29proteinuria10.3
30retinitis10.3
31sarcoma10.3
32thymoma10.3
33t-cell adult acute lymphocytic leukemia10.3
34pediatric lymphoma10.3
35childhood leukemia10.1
36hodgkin's lymphoma10.1
37lymphoblastic leukemia10.1
38adenoid cystic carcinoma10.0MYB
39viral hepatitis10.0MYB
40follicular lymphoma10.0MYB, BAX
41burkitt's lymphoma10.0MYB, BAX
42acute erythroid leukemia10.0MYB, BAX
43chronic lymphocytic leukemia10.0MYB, BAX
44cervical cancer10.0MYB, BAX

Graphical network of the top 20 diseases related to Acute T Cell Leukemia:



Diseases related to acute t cell leukemia

Clinical Features for Acute T Cell Leukemia

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Sources:
46OMIM
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Clinical features from OMIM:

613065

Drugs & Therapeutics for Acute T Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute T Cell Leukemia

Drug clinical trials:

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Genetic Tests for Acute T Cell Leukemia

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Anatomical Context for Acute T Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute T Cell Leukemia:

32
T cells, Myeloid, B cells, Bone, Bone marrow, Monocytes, Thymus, Liver, Skin, Breast, Brain, Spinal cord

Animal Models for Acute T Cell Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute T Cell Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.0NUP214, MYB, BAX, PICALM

Publications for Acute T Cell Leukemia

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50PubMed
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Articles related to Acute T Cell Leukemia:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
T-cell adoptive immunotherapy for acute lymphoblastic leukemia. (24319203)
2013
2
Interleukin-2 priming chemotherapy: a strategy to improve the remission of refractory/relapsed T cell acute lymphoblastic leukemia. (24074835)
2013
3
Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia. (23687089)
2013
4
Increased Th22 cells as well as Th17 cells in patients with adult T-cell acute lymphoblastic leukemia. (24064425)
2013
5
Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance. (24241349)
2013
6
Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells. (22430636)
2012
7
Upregulation of T-Cell-Specific Transcription Factor Expression in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL). (24385720)
2012
8
Acute pancreatitis: the onset digestive manifestation, in a patient with adult T-cell leukemia/lymphoma. (23188452)
2012
9
The indicative effect of Notch1 expression for the prognosis of T-cell acute lymphocytic leukemia: a systematic review. (22311010)
2012
10
Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma. (21326611)
2011
11
PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia. (21551237)
2011
12
Am80 inhibits stromal cell-derived factor-1-induced chemotaxis in T-cell acute lymphoblastic leukemia cells. (20141446)
2010
13
Diversity of T-cell receptor gene rearrangements in South Indian patients with common acute lymphoblastic leukemia. (19801787)
2009
14
T cell acute lymphoblastic leukemia: NOTCHing the way toward a better treatment outcome. (19185842)
2009
15
Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells. (19734423)
2009
16
Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways. (18322253)
2008
17
Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia. (18079736)
2008
18
In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia. (18322257)
2008
19
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. (18577685)
2008
20
CD34 expression is associated with poor survival in pediatric T-cell acute lymphoblastic leukemia. (18683236)
2008
21
Two cell lines of t(8;21) acute myeloid leukemia with activating KIT exon 17 mutation: models for the 'second hit' hypothesis. (18385756)
2008
22
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. (17435759)
2007
23
Expression of CD4+ CD25+ regulatory T cells in the patients with acute lymphocytic leukemia]. (17488606)
2007
24
CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23+CD5+ B Cells and CD8+ T cells. (17709502)
2007
25
Donor cell-derived chronic myeloproliferative disease with t(7;11)(p15;p15) after cord blood transplantation in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. (17875537)
2007
26
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (16847353)
2006
27
Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. (16621969)
2006
28
High survival rate with the LMT-89 regimen in lymphoblastic lymphoma (LL), but not in T-cell acute lymphoblastic leukemia (T-ALL). (16511514)
2006
29
Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival. (14684422)
2004
30
Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. (14604958)
2004
31
Comparative analysis of T-cell receptor gene rearrangements at diagnosis and relapse of T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease and reveals the occurrence of second T-ALL. (14576730)
2003
32
The analogy in cell immunophenotype and parameters of cell cycle of ectopic thymus, normal thymus, and some acute lymphoblastic leukemia of T-phenotype. (12458329)
2002
33
Acute myelogenous leukemia blasts as accessory cells during in vitro T lymphocyte activation. (11161436)
2000
34
Detection of methylthioadenosine phosphorylase (MTAP) and p16 gene deletion in T cell acute lymphoblastic leukemia by real-time quantitative PCR assay. (10803528)
2000
35
Rapid, multifluorescent TCRG Vgamma and Jgamma typing: application to T cell acute lymphoblastic leukemia and to the detection of minor clonal populations. (10865981)
2000
36
Immunophenotypic and immunogenotypic characteristics of TCRgammadelta+ T cell acute lymphoblastic leukemia. (10025894)
1999
37
Prognostic significance of immunoglobulin and T cell receptor gene rearrangements in patients with acute myeloid leukemia: Taiwan experience. (10512175)
1999
38
V-J junctional sequences of T cell receptor gamma gene in acute lymphocytic leukemia. (7755873)
1995
39
Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia. (8774979)
1995
40
Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study. (7605997)
1995
41
SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia. (8350619)
1993
42
Role of the p53 tumor suppressor gene in the pathogenesis and in the suppression of acute lymphoblastic T-cell leukemia. (1602834)
1992
43
T-cell receptor gamma/delta expressing acute leukemia emerging from sideroblastic anemia: morphological, immunological, and cytogenetic features. (1373459)
1992
44
Karyotype and T-cell receptor expression in T-lineage acute lymphoblastic leukemia. (1377008)
1992
45
Detection of T-cell receptor gamma chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemia. (1850309)
1991
46
Acute unclassified leukemia originating from undifferentiated cells with the aberrant rearrangement and expression of immunoglobulin and T-cell receptor genes. (1827509)
1991
47
A case of CD3+, CD4-, CD8-, WT31- acute T-cell leukemia. (2787596)
1989
48
Insulin receptor overexpression in a human pre-B acute lymphocytic leukemia cell line with a t(1;19) chromosome translocation near the INSR locus. (2539148)
1989
49
Eaton-Lambert syndrome in a patient with acute T cell lymphocytic leukemia. (3059524)
1988
50
T-cell acute lymphoblastic leukemia relapsing as acute myelomonocytic leukemia and terminating possibly as chronic myelocytic leukemia. (3492913)
1987

Genetic Variations for Acute T Cell Leukemia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute T Cell Leukemia:

62
id Symbol AA change Variation ID SNP ID
1PAX5p.Gly183SerVAR_070682

Expression for genes affiliated with Acute T Cell Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute T Cell Leukemia

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Pathways for genes affiliated with Acute T Cell Leukemia

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Compounds for genes affiliated with Acute T Cell Leukemia

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44Novoseek, 24HMDB
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Compounds related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
14-hydroxynonenal44 2410.0MYB, BAX
2flavonoid448.7MYB, BAX

GO Terms for genes affiliated with Acute T Cell Leukemia

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16Gene Ontology
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Biological processes related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycleGO:0517269.1NUP214, BAX

Products for genes affiliated with Acute T Cell Leukemia

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Sources for Acute T Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet