MCID: ACT020
MIFTS: 59

Acute T Cell Leukemia malady

Immune category

Summaries for Acute T Cell Leukemia

Sources:
47OMIM, 33MalaCards
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MalaCards: Acute T Cell Leukemia, also known as t-cell acute lymphoblastic leukemia, is related to acute leukemia and acute myeloid leukemia. An important gene associated with Acute T Cell Leukemia is LAP (Laryngeal adductor paralysis), and among its related pathways are FasL/ CD95L signaling and Regulation by c-FLIP. The compounds butyrate and aloeemodin have been mentioned in the context of this disorder. Affiliated tissues include liver, tongue and spinal cord, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Description from OMIM:47 613065

Aliases & Classifications for Acute T Cell Leukemia

Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

acute t cell leukemia 8 10
t-cell acute lymphoblastic leukemia 8 9 47
leukemia, t-cell acute lymphoblastic 9 47
leukemia, acute t-cell lymphoblastic 9 47
leukemia, acute t-cell 9 47
precursor t-cell lymphoblastic leukemia-lymphoma 61
precursor t lymphoblastic leukemia 8


External Ids:

Disease Ontology8 DOID:5603
MeSH35 D015459
NCIt40 C3184

Related Diseases for Acute T Cell Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Acute T Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.2TRB, MYB, CD7, LMO2, LMO1, NOTCH1
2acute myeloid leukemia31.0NUP214, LPP, PICALM
3t-cell leukemia30.9CASP3, FAS, FASLG, MYB, CD7, CYCS
4precursor t-cell acute lymphoblastic leukemia30.9MYB, NUP214, CD7, CYCS, HOXA@, LMO2
5lymphoblastic lymphoma30.6TRB, CD7, LMO2, NOTCH1
6fanconi's anemia30.4PARP1
7wilms tumor30.4NOTCH1, MYB
8ataxia telangiectasia30.4PARP1, BAX, CASP3
9acute lymphoblastic leukemia, childhood10.9
10pediatric t-cell leukemia10.7
11adult t-cell leukemia10.7
12leukemia, acute pre-b-cell10.6
13pre-b-cell acute lymphoblastic leukemia10.6
14leukemia, acute lymphoblastic 210.5
15acute myelomonocytic leukemia10.4
16glucocorticoid resistance10.4
17leukemia-2, t-cell acute lymphoblastic10.4
18precursor b-cell acute lymphoblastic leukemia10.4
19lymphocytic leukemia, acute t-cell10.3
20acute pancreatitis10.3
21precursor b lymphoblastic lymphoma/leukemia10.3
22hemophagocytic lymphohistiocytosis10.3
23juvenile xanthogranuloma10.3
24juvenile myelomonocytic leukemia10.3
25mast-cell leukemia10.3
26null-cell leukemia10.3
27adult lymphoma10.3
28anaplastic large cell lymphoma10.3
29small cell sarcoma10.3
30aleukemic leukemia cutis10.3
31thymoma10.3
32acute biphenotypic leukemia10.3
33acute myeloid leukemia, adult10.3
34acute non lymphoblastic leukemia10.3
35bone marrow necrosis10.3
36chronic myelomonocytic leukemia10.3
37leukemia, t-cell, chronic10.3
38cytomegalovirus retinitis10.3
39desmoplastic small round cell tumor10.3
40ataxia10.3
41hypoxia10.3
42leukopenia10.3
43hematopoietic stem cell transplantation10.3
44t-cell adult acute lymphocytic leukemia10.3
45pediatric lymphoma10.3
46leukemia/lymphoma, t-cell10.2
47malignant mesothelioma10.0CD7
48nephritis10.0CYCS
49thyroiditis10.0FASLG
50lupus erythematosus10.0CYCS

Graphical network of the top 20 diseases related to Acute T Cell Leukemia:



Diseases related to acute t cell leukemia

Clinical Features for Acute T Cell Leukemia

Sources:
47OMIM
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Clinical features from OMIM:

613065

Drugs & Therapeutics for Acute T Cell Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Acute T Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute T Cell Leukemia

Search NIH Clinical Center for Acute T Cell Leukemia

Search CenterWatch for Acute T Cell Leukemia

Genetic Tests for Acute T Cell Leukemia

Anatomical Context for Acute T Cell Leukemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Acute T Cell Leukemia:

33
Liver, Tongue, Spinal cord, Brain, Kidney, Lung, Spleen, Uterus, Bone marrow, Whole blood, Thymus, Smooth muscle, Small intestine, Thyroid, Breast, Testis, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Testis germ

Animal Models for Acute T Cell Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Acute T Cell Leukemia

Sources:
51PubMed
See all sources

Articles related to Acute T Cell Leukemia:

(show top 50)    (show all 992)
idTitleAuthorsYear
1
Monitoring of acute myeloid leukemia patients after allogeneic stem cell transplantation employing semi-automated CD34+ donor cell chimerism analysis. (24352219)
2014
2
Haploidentical cellular therapy in elderly patients with acute myeloid leukemia: description of its use in high risk patients. (23686413)
2013
3
A 7-year-old boy with renal insufficiency and proteinuria after stem cell transplant for T-cell acute lymphoblastic leukemia. (23391318)
2013
4
Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia. (23412094)
2013
5
CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia. (23585892)
2013
6
Efficacy of hematopoietic stem cell transplantation and prophylactic triple intrathecal therapy in a child with multiple CNS relapse of acute lymphoblastic leukemia. (23781848)
2013
7
Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience. (24249320)
2013
8
Lymphocyte recovery on day 100 after allogeneic hematopoietic stem cell transplant predicts non-relapse mortality in patients with acute leukemia or myelodysplastic syndrome. (23841507)
2013
9
Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression. (24211243)
2013
10
Aquaporin 9, a promising predictor for the cytocidal effects of arsenic trioxide in acute promyelocytic leukemia cell lines and primary blasts. (23563754)
2013
11
Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells. (23476680)
2013
12
B-cell transcription factor expression and immunoglobulin gene rearrangement frequency in acute myeloid leukemia with t(8;21)(q22;q22). (23955454)
2013
13
Blast cell deficiency of CD11a as a marker of acute megakaryoblastic leukemia and transient myeloproliferative disease in children with and without Down syndrome. (23450818)
2013
14
124I-anti-CD52 dosimetry before radioimmunotherapy as part of conditioning for stem cell transplantation in acute leukemia. (22391715)
2012
15
The variant translocation of ABL1 gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leukemia. (22380496)
2012
16
Leser-TrAclat sign presenting in a patient with recurrent pre-B-cell acute lymphocytic leukemia. (22439308)
2012
17
Hematopoietic stem cell transplantation in children with acute leukemia: similar outcomes in recipients of umbilical cord blood versus marrow or peripheral blood stem cells from related or unrelated donors. (22474464)
2012
18
Prognostic role of pre-transplantation serum C-reactive protein levels in patients with acute leukemia undergoing myeloablative allogeneic stem cell transplantation. (23061760)
2012
19
microRNA methylation profile has prognosis impact in acute lymphoblastic leukemia patients undergoing stem cell transplantation. (21172447)
2011
20
Precursor B-cell acute lymphoblastic leukemia after thymoma and myasthenia gravis: report of a case and review of the literature. (21528677)
2011
21
Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation. (20854920)
2011
22
The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells. (19449004)
2010
23
Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells. (20072159)
2010
24
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. (19641190)
2009
25
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia. (19351820)
2009
26
Association of high proliferation in adult T-cell leukemia cells with apoptosis, and expression of p53 protein in acute type ATL. (18434687)
2008
27
Hemophagocytic lymphohistiocytosis onset during induction therapy for precursor B-cell acute lymphoblastic leukemia. (19131791)
2008
28
Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells. (17389244)
2007
29
Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. (17855649)
2007
30
The role of graft-versus-host disease in the inhibition of normal B-lymphopoiesis and leukemic control of B-lineage acute lymphocytic leukemia after allogeneic stem cell transplantation. (16531250)
2006
31
Myeloid/natural killer cell precursor acute leukemia with tetraploidy. (16337859)
2005
32
Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. (15731175)
2005
33
Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols. (15990867)
2005
34
Acute myeloid leukemia cells in G0 phase of the cell cycle that are unresponsive to conventional chemotherapy are sensitive to treatment with granulocyte-macrophage colony-stimulating factor/diphtheria toxin fusion proteins. (15102480)
2004
35
Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation. (15297313)
2004
36
A tetraspanin-family protein, T-cell acute lymphoblastic leukemia-associated antigen 1, is induced by the Ewing's sarcoma-Wilms' tumor 1 fusion protein of desmoplastic small round-cell tumor. (14633590)
2003
37
Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia. (11494125)
2001
38
Granulocyte colony-stimulating factor receptor mutations in severe congenital neutropenia transforming to acute myelogenous leukemia confer resistance to apoptosis and enhance cell survival. (10706885)
2000
39
All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells. (10907644)
2000
40
Expression of B cell-associated transcription factors in B-cell precursor acute lymphoblastic leukemia cells: association with PU.1 expression, phenotype, and immunogenotype. (10905058)
2000
41
Thrombopoietin in the treatment of acute myeloid leukemia and in stem-cell transplantation. (10831287)
2000
42
Monocyte-macrophages, granulocyte-macrophage colony-stimulating factor, and prolonged survival among patients with acute myeloid leukemia and stem cell transplants. (9636847)
1998
43
Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells. (8643682)
1996
44
The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells. (8874206)
1996
45
A case of B-cell type acute lymphocytic leukemia presenting ophthalmoplegia. (8365069)
1993
46
Effects of transforming growth factor beta 1 on growth and apoptosis of human acute myelogenous leukemia cells. (8324749)
1993
47
Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. (1311214)
1992
48
A case of infantile acute monocytic leukemia caused by vertical transmission of the mother's leukemic cells. (2406008)
1990
49
Terminal deoxynucleotidyl transferase and CD7 expression in acute myeloid leukemias are not associated with a high frequency of immunoglobulin and/or T cell receptor gene rearrangement. (1694941)
1990
50
Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells. (2437586)
1987

Genetic Variations for Acute T Cell Leukemia

Expression for genes affiliated with Acute T Cell Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Acute T Cell Leukemia

Search GEO for disease gene expression data for Acute T Cell Leukemia.

Pathways for genes affiliated with Acute T Cell Leukemia

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG, 56SinoBiological, 53R&D Systems, 4Cell Signaling Technology
See all sources

Pathways related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9FASLG, FAS
2
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9.9FASLG, FAS
3
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9.8CYCS, CASP3
49.7PARP1, NOTCH1, MYB
59.7CYCS, BAX, FAS
6
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9.6CASP3, BAX, CYCS
7
Apoptosis and survival Lymphotoxin-beta receptor signaling
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9.6CYCS, BAX, CASP3
8
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9.6CASP3, BAX, CYCS
9
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9.6CASP3, BAX, CYCS
10
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9.6CYCS, BAX, CASP3
11
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9.6BAX, FAS, CASP3
12
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9.5CASP3, FAS, FASLG
139.3BAX, FASLG, FAS, CASP3
14
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9.3CYCS, BAX, FAS, CASP3
15
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9.3CASP3, FAS, FASLG, CYCS
16
Hide members
9.3CASP3, FAS, FASLG, CYCS
17
Hide members
9.0CASP3, FAS, FASLG, BAX, CYCS
189.0CYCS, BAX, FASLG, FAS, CASP3
19
Hide members
9.0CYCS, BAX, FASLG, FAS, CASP3
20
Hide members
9.0CASP3, FAS, FASLG, BAX, CYCS
21
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
9.0CASP3, FAS, FASLG, BAX, CYCS
22
Hide members
9.0CASP3, FAS, FASLG, BAX, CYCS
23
Hide members
9.0CASP3, FAS, FASLG, BAX, CYCS
24
Hide members
9.0CASP3, FAS, FASLG, BAX, CYCS
25
Hide members
9.0CASP3, FAS, FASLG, BAX, PARP1
26
Hide members
8.8CASP3, FAS, FASLG, BAX, NUP214, CYCS
278.7CASP3, FAS, FASLG, BAX, CYCS, PARP1
28
Apoptosis and survival Caspase cascade
Hide members
8.7PARP1, CYCS, BAX, FASLG, FAS, CASP3

Compounds for genes affiliated with Acute T Cell Leukemia

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1butyrate4510.5MYB
2aloeemodin459.9CYCS, BAX, CASP3
3honokiol459.9PARP1, BAX, CASP3
4bongkrekic acid459.8CYCS, BAX, CASP3
5ly294002459.8PARP1, NOTCH1, CYCS, BAX
6d-api459.7CASP3, FAS, BAX, PARP1
7polyadenosine diphosphate ribose459.7CASP3, FAS, BAX, PARP1
8sanguinarine459.7PARP1, CYCS, BAX, CASP3
9pd 169316459.7PARP1, CYCS, BAX, CASP3
10beta-lapachone459.7CASP3, FAS, BAX, PARP1
11diallyl disulfide459.7CASP3, BAX, CYCS, PARP1
122-chlorodeoxyadenosine459.7FAS, FASLG, BAX, PARP1
13noxa459.6CYCS, BAX, FAS, CASP3
14hoechst 33342459.6CASP3, FAS, BAX, PARP1
15betulinic acid45 2910.6PARP1, CYCS, FASLG, CASP3
16calpeptin45 6010.6CASP3, BAX, CYCS, PARP1
174,6-diamidino-2-phenylindole459.6PARP1, BAX, CASP3
18tpck459.5CASP3, FAS, CYCS, PARP1
19fludarabine45 1110.5FAS, FASLG, BAX, PARP1
20oridonin459.4PARP1, CYCS, BAX, FAS, CASP3
21n-(4-hydroxyphenyl)retinamide459.4PARP1, CYCS, BAX, CASP3
22vitamin e succinate459.4CASP3, FAS, BAX, CYCS, PARP1
23cd 437459.4CASP3, FAS, BAX, CYCS, PARP1
24sulforaphane459.4CASP3, FAS, BAX, CYCS, PARP1
25bortezomib45 1110.4CASP3, FASLG, BAX, CYCS, PARP1
26arsenite45 2410.4CASP3, FAS, FASLG, BAX, PARP1
27rottlerin459.3CASP3, FAS, FASLG, CYCS, PARP1
28ursolic acid459.3PARP1, BAX, CASP3
294-hydroxynonenal45 2410.2CASP3, FAS, BAX, MYB, CYCS, PARP1
30agarose459.2CASP3, FAS, FASLG, BAX, PARP1
31dutp459.2CYCS, BAX, FASLG, FAS, CASP3, PARP1
323-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.2CASP3, FAS, FASLG, BAX, CYCS, PARP1
33suberoylanilide hydroxamic acid459.2CASP3, FAS, FASLG, BAX, CYCS, PARP1
34c2ceramide459.2CASP3, FAS, FASLG, BAX, CYCS, PARP1
35adpribose459.1CASP3, FAS, FASLG, BAX, CYCS, PARP1
36sp 60012545 6010.1CASP3, FAS, FASLG, BAX, CYCS, PARP1
37camptothecin45 60 1111.1CASP3, FAS, FASLG, BAX, CYCS, PARP1
38mg 13245 6010.1CASP3, FAS, FASLG, BAX, CYCS, PARP1
39ceramide459.1CASP3, FAS, FASLG, BAX, CYCS, PARP1
40phosphatidylserine45 29 1111.1CASP3, FAS, FASLG, BAX, CYCS, PARP1
41etoposide45 50 60 1112.0CASP3, FAS, FASLG, BAX, CYCS, PARP1
42n acetylcysteine459.0CASP3, FAS, FASLG, BAX, CYCS, PARP1
43sb 20358045 6010.0CASP3, FAS, FASLG, BAX, CYCS, PARP1
44paclitaxel45 50 1111.0CASP3, FAS, FASLG, BAX, CYCS, PARP1
45actinomycin d458.9CASP3, FAS, FASLG, BAX, MYB, CYCS
46pd 98,059458.8CASP3, FAS, FASLG, BAX, CYCS, PARP1
47cycloheximide458.7CASP3, FAS, FASLG, BAX, MYB, CYCS
48doxorubicin45 50 1110.7CASP3, FAS, FASLG, BAX, MYB, CYCS
49h2o2458.4CASP3, FAS, FASLG, BAX, MYB, CYCS
50retinoic acid45 249.3FAS, FASLG, BAX, MYB, CYCS, NOTCH1

GO Terms for genes affiliated with Acute T Cell Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.7PARP1, FAS, FASLG, PICALM, LPP, BAX

Biological processes related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1retinal cell programmed cell deathGO:04666610.2BAX, FASLG
2inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
3nuclear fragmentation involved in apoptotic nuclear changeGO:03026410.1BAX, CASP3
4transformed cell apoptotic processGO:00692710.1FAS, BAX
5activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cGO:0086359.9CYCS, BAX, CASP3
6regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.9FAS, FASLG
7apoptotic DNA fragmentationGO:0063099.9CASP3, BAX, CYCS
8B cell homeostasisGO:0017829.9BAX, CASP3
9neuron apoptotic processGO:0514029.9CASP3, FAS, BAX
10positive regulation of neuron apoptotic processGO:0435259.8CASP3, FASLG, BAX
11extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.8CASP3, FAS, FASLG
12negative regulation of stem cell differentiationGO:20007379.8NOTCH1, ZFP36L2
13intrinsic apoptotic signaling pathwayGO:0971939.8CYCS, BAX, CASP3
14activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.8BAX, FASLG, FAS
15somatic stem cell divisionGO:0481039.7NOTCH1, ZFP36L2
16apoptotic signaling pathwayGO:0971909.6BAX, FASLG, FAS, CASP3
17positive regulation of apoptotic processGO:0430659.4CASP3, FAS, FASLG, BAX, NOTCH1
18negative regulation of transcription from RNA polymerase II promoterGO:0001229.1PARP1, NOTCH1, LMO1, MYB, FASLG
19apoptotic processGO:0069158.7CASP3, FAS, FASLG, BAX, CYCS

Molecular functions related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionGO:00119010.0NOTCH1, LMO2

Products for genes affiliated with Acute T Cell Leukemia

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Sources for Acute T Cell Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet