MCID: ACT020
MIFTS: 41

Acute T Cell Leukemia malady

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Summaries for Acute T Cell Leukemia

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MalaCards based summary: Acute T Cell Leukemia, also known as t-cell acute lymphoblastic leukemia, is related to acute lymphoblastic leukemia and myeloid leukemia. An important gene associated with Acute T Cell Leukemia is MYB (v-myb avian myeloblastosis viral oncogene homolog). The compound leptomycin b have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are cellular and embryogenesis.

Aliases & Classifications for Acute T Cell Leukemia

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Acute T Cell Leukemia, Aliases & Descriptions:

Name: Acute T Cell Leukemia 8 10
T-Cell Acute Lymphoblastic Leukemia 8 9 46
Leukemia, T-Cell Acute Lymphoblastic 9 46
Leukemia, Acute T-Cell Lymphoblastic 9 46
 
Leukemia, Acute T-Cell 9 46
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 62
Precursor T Lymphoblastic Leukemia 8


Classifications:



External Ids:

Disease Ontology8 DOID:5603
NCIt39 C3184
MeSH34 D015459

Related Diseases for Acute T Cell Leukemia

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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia T-Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic Leukemia, Acute Pre-B-Cell

Diseases related to Acute T Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1acute lymphoblastic leukemia32.0MYB, LMO2, PICALM
2myeloid leukemia31.0MYB, PICALM
3t-cell leukemia30.8MYB, LMO4, LMO2, LMO1
4leukemia30.4PICALM, NUP214, LMO1, LMO2, MYB
5precursor t-cell acute lymphoblastic leukemia30.4PICALM, NUP214, LMO1, LMO2, LMO4, MYB
6lymphoblastic leukemia11.6
7lymphoblastic lymphoma10.9
8acute myeloid leukemia10.6
9t-cell acute lymphoblastic leukemia, somatic10.5
10lymphocytic leukemia, acute t-cell10.3
11acute biphenotypic leukemia10.3
12anaplastic large cell lymphoma10.3
13ataxia telangiectasia10.3
14b-cell lymphomas10.3
15hematopoietic stem cell transplantation10.3
16hemophagocytic lymphohistiocytosis10.3
17juvenile myelomonocytic leukemia10.3
18wilms tumor10.3
19langerhans-cell histiocytosis10.3
20pure red-cell aplasia10.3
21juvenile xanthogranuloma10.3
22aleukemic leukemia cutis10.3
23histiocytosis10.3
24hyperostosis10.3
25laryngitis10.3
26meningioma10.3
27neuroblastoma10.3
28pancreatitis10.3
29paraplegia10.3
30pericardial effusion10.3
31proteinuria10.3
32retinitis10.3
33sarcoma10.3
34thymoma10.3
35acute myelomonocytic leukemia10.3
36cytomegalovirus retinitis10.3
37desmoplastic small round cell tumor10.3
38glucocorticoid resistance10.3
39ataxia10.3
40hypoxia10.3
41leukopenia10.3
42t-cell adult acute lymphocytic leukemia10.3
43acute leukemia9.8LMO1, LMO2, MYB
44burkitt's lymphoma9.8MYB, LMO2, PICALM
45breast cancer9.4HSD17B1, LMO2, LMO4, MYB

Graphical network of the top 20 diseases related to Acute T Cell Leukemia:



Diseases related to acute t cell leukemia

Symptoms for Acute T Cell Leukemia

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Drugs & Therapeutics for Acute T Cell Leukemia

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Drug clinical trials:

Search ClinicalTrials for Acute T Cell Leukemia

Search NIH Clinical Center for Acute T Cell Leukemia

Genetic Tests for Acute T Cell Leukemia

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Anatomical Context for Acute T Cell Leukemia

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MalaCards organs/tissues related to Acute T Cell Leukemia:

32
T cells, B cells

Animal Models for Acute T Cell Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Acute T Cell Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.1LPP, MYB, LMO2, NUP214, PICALM
2MP:00053808.1PICALM, NUP214, LMO2, LMO4, MYB
3MP:00107686.9LPP, MYB, LMO4, LMO2, LMO1, NUP214

Publications for Acute T Cell Leukemia

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Articles related to Acute T Cell Leukemia:

(show all 23)
idTitleAuthorsYear
1
Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line: Prooxidative potential of hydroxylated resveratrol analogs. (24398169)
2014
2
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells. (24394624)
2014
3
Conversion of estrone to 17 beta-estradiol in Jurkat acute T cell leukemia Hut-78 T- and Raji B lymphoma cell lines in vitro. (23540283)
2013
4
Combined treatment with fenretinide and indomethacin induces AIF-mediated, non-classical cell death in human acute T-cell leukemia Jurkat cells. (22387538)
2012
5
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. (20008304)
2010
6
Complete regression of massive cardiac involvement associated with acute T cell leukemia following chemotheraphy. (17320483)
2008
7
Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias. (16502262)
2006
8
CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. (16332967)
2006
9
Post-transplantation lymphoproliferative disorder of recipient origin in a boy with acute T-cell leukemia with detection of B-cell clonality 3 months before stem cell transplantation. (16266918)
2005
10
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). (15774621)
2005
11
Denileukin diftitox and hyper-CVAD in the treatment of human T-cell lymphotropic virus 1-associated acute T-cell leukemia/lymphoma. (14715100)
2003
12
A novel post-transcriptional splicing form of the acute T cell leukemia proto-oncogene Lmo2. (18763096)
2001
13
Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (8545129)
1995
14
Successful treatment of human acute T-cell leukemia in SCID mice using the anti-CD7-deglycosylated ricin A-chain immunotoxin DA7. (1371092)
1992
15
Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion. (2208004)
1990
16
Antigen-specific recognition of autologous leukemia cells and allogeneic class-I MHC antigens by IL-2-activated cytotoxic T cells from a patient with acute T-cell leukemia. (2546621)
1989
17
Constitutive expression and abnormal glycosylation of transferrin receptor in acute T-cell leukemia. (2582441)
1989
18
A case of CD3+, CD4-, CD8-, WT31- acute T-cell leukemia. (2787596)
1989
19
Cyclosporine A and acute T cell leukemia in the rat. (3164536)
1988
20
Childhood primary cutaneous non-T/non-B lymphoma followed by acute T-cell leukemia. (3486034)
1986
21
T-lymphoblasts with erythropoietic helper function in acute T-cell leukemia. (2978965)
1986
22
t(11;19)(q23;p11) in a child with acute T-cell leukemia. (3855377)
1985
23
Human serum thymic factor in detecting acute T cell leukemia. (311636)
1978

Variations for Acute T Cell Leukemia

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Expression for genes affiliated with Acute T Cell Leukemia

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Expression patterns in normal tissues for genes affiliated with Acute T Cell Leukemia

Search GEO for disease gene expression data for Acute T Cell Leukemia.

Pathways for genes affiliated with Acute T Cell Leukemia

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Compounds for genes affiliated with Acute T Cell Leukemia

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Sources:
44Novoseek, 61Tocris Bioscience
See all sources

Compounds related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1leptomycin b44 6110.3LPP, NUP214

GO Terms for genes affiliated with Acute T Cell Leukemia

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Cellular components related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:0059259.3LPP, NUP214
2nucleusGO:0056347.0LPP, LMO2, LMO1, HSD17B1, NUP214, PICALM

Biological processes related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thymus developmentGO:0485389.6MYB, LMO4
2positive regulation of transcription from RNA polymerase II promoterGO:0459448.4MYB, LMO4, LMO2, LMO1

Molecular functions related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:0082708.2LPP, LMO4, LMO2, LMO1

Products for genes affiliated with Acute T Cell Leukemia

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  • Antibodies
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Sources for Acute T Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet