MCID: ACT020
MIFTS: 43

Acute T Cell Leukemia malady

Immune diseases category

Summaries for Acute T Cell Leukemia

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46OMIM, 32MalaCards
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MalaCards: Acute T Cell Leukemia, also known as t-cell acute lymphoblastic leukemia, is related to acute leukemia and acute myeloid leukemia. An important gene associated with Acute T Cell Leukemia is LAP (Laryngeal adductor paralysis). The compounds 4-hydroxynonenal and flavonoid have been mentioned in the context of this disorder. Affiliated tissues include t cells, myeloid and b cells, and related mouse phenotype cellular.

Description from OMIM:46 613065

Aliases & Classifications for Acute T Cell Leukemia

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8Disease Ontology, 9diseasecard, 46OMIM, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

acute t cell leukemia 8 10
t-cell acute lymphoblastic leukemia 8 9 46
leukemia, t-cell acute lymphoblastic 9 46
leukemia, acute t-cell lymphoblastic 9 46
leukemia, acute t-cell 9 46
precursor t-cell lymphoblastic leukemia-lymphoma 60
precursor t lymphoblastic leukemia 8


External Ids:

Disease Ontology8 DOID:5603
MeSH34 D015459
NCIt39 C3184

Related Diseases for Acute T Cell Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia T-Cell Leukemia
Leukemia, B-Cell, Chronic Leukemia, T-Cell, Chronic
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3

Diseases related to Acute T Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.2MYB
2acute myeloid leukemia31.0PICALM, NUP214
3myeloid leukemia31.0MYB, BAX, PICALM
4precursor t-cell acute lymphoblastic leukemia30.7NUP214, MYB, BAX, PICALM
5cutaneous t cell lymphoma30.2BAX, MYB
6adult t-cell leukemia10.9
7leukemia10.8
8t-cell leukemia10.8
9lymphocytic leukemia, acute t-cell10.3
10acute pancreatitis10.3
11pure red-cell aplasia10.3
12hemophagocytic lymphohistiocytosis10.3
13juvenile xanthogranuloma10.3
14ataxia telangiectasia10.3
15juvenile myelomonocytic leukemia10.3
16adult lymphoma10.3
17anaplastic large cell lymphoma10.3
18small cell sarcoma10.3
19acute lymphocytic leukemia10.3
20aleukemic leukemia cutis10.3
21histiocytosis10.3
22hyperostosis10.3
23langerhans-cell histiocytosis10.3
24meningioma10.3
25neuroblastoma10.3
26pancreatitis10.3
27paraplegia10.3
28pericardial effusion10.3
29proteinuria10.3
30retinitis10.3
31sarcoma10.3
32thymoma10.3
33t-cell adult acute lymphocytic leukemia10.3
34pediatric lymphoma10.3
35childhood leukemia10.1
36hodgkin's lymphoma10.1
37lymphoblastic leukemia10.1
38adenoid cystic carcinoma10.0MYB
39viral hepatitis10.0MYB
40follicular lymphoma10.0MYB, BAX
41burkitt's lymphoma10.0MYB, BAX
42acute erythroid leukemia10.0MYB, BAX
43chronic lymphocytic leukemia10.0MYB, BAX
44cervical cancer10.0MYB, BAX

Graphical network of the top 20 diseases related to Acute T Cell Leukemia:



Diseases related to acute t cell leukemia

Clinical Features for Acute T Cell Leukemia

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Sources:
46OMIM
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Clinical features from OMIM:

613065

Drugs & Therapeutics for Acute T Cell Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute T Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute T Cell Leukemia

Search NIH Clinical Center for Acute T Cell Leukemia

Search CenterWatch for Acute T Cell Leukemia

Genetic Tests for Acute T Cell Leukemia

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Anatomical Context for Acute T Cell Leukemia

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32MalaCards
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MalaCards organs/tissues related to Acute T Cell Leukemia:

32
T cells, Myeloid, B cells, Bone, Bone marrow, Monocytes, Liver, Skin, Thymus, Spinal cord, Brain, Breast

Animal Models for Acute T Cell Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute T Cell Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.0NUP214, MYB, BAX, PICALM

Publications for Acute T Cell Leukemia

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50PubMed
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Articles related to Acute T Cell Leukemia:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a group for research in adult acute lymphoblastic leukemia study. (24166518)
2013
2
CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia. (23585892)
2013
3
Conversion of estrone to 17 beta-estradiol in Jurkat acute T cell leukemia Hut-78 T- and Raji B lymphoma cell lines in vitro. (23540283)
2013
4
Cytomegalovirus retinitis during maintenance therapy for T-cell acute lymphoblastic leukemia. (23242328)
2013
5
Potentiation of a novel palladium (II) complex lethality with bee venom on the human T-cell acute lymphoblastic leukemia cell line (MOLT-4). (24090289)
2013
6
Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells. (23788636)
2013
7
C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. (24040340)
2013
8
Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement. (21720744)
2012
9
B-cell acute lymphoblastic leukemia with t(4;11)(q21;q23) in a young woman: evolution into mixed phenotype acute leukemia with additional chromosomal aberrations in the course of therapy. (23087804)
2012
10
Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia. (21217079)
2011
11
Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia. (21880637)
2011
12
Use of zidovudine and interferon alfa with chemotherapy improves survival in both acute and lymphoma subtypes of adult T-cell leukemia/lymphoma. (22042945)
2011
13
p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia. (21903579)
2011
14
Functional genomics of tumor suppressor miR-196b in T-cell acute lymphoblastic leukemia. (20924650)
2011
15
Development of secondary T-cell acute lymphoblastic leukemia in a child with hemophagocytic lymphohistiocytosis. (20589661)
2010
16
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. (20008304)
2010
17
Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia. (21080944)
2010
18
Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia. (20374994)
2010
19
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. (20473312)
2010
20
T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity? (19778844)
2009
21
Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling. (18596736)
2009
22
Mechanism of CAG regimen eliminating T-cell acute lymphoblastic leukemia A3 cell line]. (19099627)
2008
23
Impairment of granulo-monocytic development of human common myeloid progenitors but not of granulo-monocytic progenitors by decreasing stem cell leukemia/T-cell acute leukemia 1 expression. (18436863)
2008
24
Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. (17505014)
2007
25
Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma. (17296584)
2007
26
Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. (16876862)
2007
27
Rapid transformation of atypical myeloproliferative disorder with consistent t(8;13) to B-cell acute lymphoblastic leukemia: a case report. (17852454)
2007
28
EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. (16234352)
2006
29
Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15. (16826222)
2006
30
CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. (16332967)
2006
31
A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice. (15951289)
2005
32
Loss of Smad3 in acute T-cell lymphoblastic leukemia. (15295048)
2004
33
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. (14983942)
2004
34
Selectively increased expression and functions of chemokine receptor CCR9 on CD4+ T cells from patients with T-cell lineage acute lymphocytic leukemia. (14559839)
2003
35
Human acute lymphoblastic leukemia (ALL) blasts as accessory cells during T-cell activation: differences between patients in costimulatory capacity affect proliferative responsiveness and cytokine release by activated T cells. (12669246)
2003
36
Splenic artery embolization as emergency treatment of splenic rupture in a child with T-cell acute lymphocytic leukemia having t(8;14) translocation. (14515402)
2003
37
A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia. (12072207)
2002
38
The CDCREL1 gene fused to MLL in de novo acute myeloid leukemia with t(11;22)(q23;q11.2) and its frequent expression in myeloid leukemia cell lines. (11170279)
2001
39
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262. (11226526)
2001
40
Oligoclonal immunoglobulin heavy-chain and T-cell receptor delta rearrangements persist in a recurrent acute lymphoblastic leukemia with one immunoglobulin kappa rearrangement as a clonal marker. (10463485)
1999
41
Regulation of CD95 expression and CD95-mediated cell death by interferon-gamma in acute lymphoblastic leukemia with chromosomal translocation t(4;11). (10516755)
1999
42
Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia. (9446664)
1998
43
Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells. (9264377)
1997
44
Proliferation of MIELIKI a novel t(7;9) early pre-B acute lymphoblastic leukemia cell line is inhibited concomitantly by IL-4 and IL-7. (7630198)
1995
45
Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid induces apoptosis independent of maturation and Bcl-2 expression. (7630193)
1995
46
Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia. (7632931)
1995
47
Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study. (8471769)
1993
48
Lineage alteration in precursor B cell acute lymphoblastic leukemia following T cell lymphoblastic lymphoma. (1333557)
1992
49
Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion. (2208004)
1990
50
The chromosome translocation (11;14)(p13;q11) associated with T-cell acute lymphocytic leukemia: an 11p13 breakpoint cluster region. (2526665)
1989

Genetic Variations for Acute T Cell Leukemia

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Acute T Cell Leukemia:

62
id Symbol AA change Variation ID SNP ID
1PAX5p.Gly183SerVAR_070682

Expression for genes affiliated with Acute T Cell Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute T Cell Leukemia

Search GEO for disease gene expression data for Acute T Cell Leukemia.

Pathways for genes affiliated with Acute T Cell Leukemia

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Compounds for genes affiliated with Acute T Cell Leukemia

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44Novoseek, 24HMDB
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Compounds related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
14-hydroxynonenal44 2410.0MYB, BAX
2flavonoid448.7MYB, BAX

GO Terms for genes affiliated with Acute T Cell Leukemia

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16Gene Ontology
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Biological processes related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of cell cycleGO:0517269.1NUP214, BAX

Products for genes affiliated with Acute T Cell Leukemia

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Sources for Acute T Cell Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet