MCID: ACT020
MIFTS: 42

Acute T Cell Leukemia malady

Cancer diseases, Immune diseases, Skin diseases, Blood diseases, Rare diseases categories

Summaries for Acute T Cell Leukemia

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34MalaCards
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MalaCards: Acute T Cell Leukemia, also known as t-cell acute lymphoblastic leukemia, is related to lymphoblastic lymphoma and t-cell leukemia. An important gene associated with Acute T Cell Leukemia is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are Notch-mediated HES/HEY network and Neural Crest Differentiation. The compound leptomycin b have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Classifications for Acute T Cell Leukemia

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9Disease Ontology, 10diseasecard, 48OMIM, 11DISEASES, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:



Aliases & Descriptions:

acute t cell leukemia 9 11
t-cell acute lymphoblastic leukemia 9 10 48
leukemia, t-cell acute lymphoblastic 10 48
leukemia, acute t-cell lymphoblastic 10 48
leukemia, acute t-cell 10 48
precursor t-cell lymphoblastic leukemia-lymphoma 63
precursor t lymphoblastic leukemia 9


External Ids:

Disease Ontology9 DOID:5603
MeSH36 D015459
NCIt41 C3184

Related Diseases for Acute T Cell Leukemia

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18GeneCards, 19GeneDecks
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Diseases in the Acute T Cell Leukemia family:

Adult T-Cell Leukemia T-Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Acute T Cell Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic lymphoma31.2NOTCH1, LMO2
2t-cell leukemia31.1NOTCH1, LMO4, LMO2, LMO1, MYB
3leukemia31.0LMO2, PICALM, NUP214, LMO1, MYB, NOTCH1
4precursor t-cell acute lymphoblastic leukemia30.8NOTCH1, MYB, LMO4, LMO1, NUP214, LMO2
5myeloid leukemia30.7PICALM, MYB
6lymphoblastic leukemia11.5
7acute myeloid leukemia10.5
8t-cell acute lymphoblastic leukemia, somatic10.5
9lymphocytic leukemia, acute t-cell10.3
10langerhans-cell histiocytosis10.3
11pure red-cell aplasia10.3
12hemophagocytic lymphohistiocytosis10.3
13juvenile xanthogranuloma10.3
14ataxia telangiectasia10.3
15juvenile myelomonocytic leukemia10.3
16anaplastic large cell lymphoma10.3
17aleukemic leukemia cutis10.3
18histiocytosis10.3
19hyperostosis10.3
20meningioma10.3
21neuroblastoma10.3
22pancreatitis10.3
23paraplegia10.3
24pericardial effusion10.3
25proteinuria10.3
26retinitis10.3
27sarcoma10.3
28thymoma10.3
29wilms tumor10.3
30acute biphenotypic leukemia10.3
31acute myelomonocytic leukemia10.3
32b-cell lymphomas10.3
33bone marrow necrosis10.3
34cytomegalovirus retinitis10.3
35desmoplastic small round cell tumor10.3
36glucocorticoid resistance10.3
37ataxia10.3
38hypoxia10.3
39leukopenia10.3
40hematopoietic stem cell transplantation10.3
41t-cell adult acute lymphocytic leukemia10.3
42acute lymphocytic leukemia9.9PICALM, LMO2, MYB, NOTCH1
43burkitt's lymphoma9.9MYB, NOTCH1, PICALM, LMO2
44acute leukemia9.9NOTCH1, MYB, LMO1, LMO2
45breast cancer9.8HSD17B1, LMO2, LMO4, NOTCH1, MYB

Graphical network of the top 20 diseases related to Acute T Cell Leukemia:



Diseases related to acute t cell leukemia

Symptoms for Acute T Cell Leukemia

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Drugs & Therapeutics for Acute T Cell Leukemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute T Cell Leukemia

Drug clinical trials:

Search ClinicalTrials for Acute T Cell Leukemia

Search NIH Clinical Center for Acute T Cell Leukemia

Search CenterWatch for Acute T Cell Leukemia

Genetic Tests for Acute T Cell Leukemia

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Anatomical Context for Acute T Cell Leukemia

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34MalaCards
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MalaCards organs/tissues related to Acute T Cell Leukemia:

34
T cells, B cells

Animal Models for Acute T Cell Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Acute T Cell Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6PICALM, LMO2, MYB, NOTCH1
2MP:00053978.4NOTCH1, MYB, LMO4, LMO2, PICALM
3MP:00053808.1PICALM, NUP214, LMO2, LMO4, MYB, NOTCH1
4MP:00053847.7PICALM, NUP214, LMO2, MYB, LPP, NOTCH1
5MP:00107686.8NOTCH1, PICALM, NUP214, LMO1, LMO2, LMO4

Publications for Acute T Cell Leukemia

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53PubMed
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Articles related to Acute T Cell Leukemia:

(show all 23)
idTitleAuthorsYear
1
Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line: Prooxidative potential of hydroxylated resveratrol analogs. (24398169)
2014
2
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells. (24394624)
2014
3
Conversion of estrone to 17 beta-estradiol in Jurkat acute T cell leukemia Hut-78 T- and Raji B lymphoma cell lines in vitro. (23540283)
2013
4
Combined treatment with fenretinide and indomethacin induces AIF-mediated, non-classical cell death in human acute T-cell leukemia Jurkat cells. (22387538)
2012
5
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. (20008304)
2010
6
Complete regression of massive cardiac involvement associated with acute T cell leukemia following chemotheraphy. (17320483)
2008
7
Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias. (16502262)
2006
8
CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. (16332967)
2006
9
Post-transplantation lymphoproliferative disorder of recipient origin in a boy with acute T-cell leukemia with detection of B-cell clonality 3 months before stem cell transplantation. (16266918)
2005
10
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). (15774621)
2005
11
Denileukin diftitox and hyper-CVAD in the treatment of human T-cell lymphotropic virus 1-associated acute T-cell leukemia/lymphoma. (14715100)
2003
12
A novel post-transcriptional splicing form of the acute T cell leukemia proto-oncogene Lmo2. (18763096)
2001
13
Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. (8545129)
1995
14
Successful treatment of human acute T-cell leukemia in SCID mice using the anti-CD7-deglycosylated ricin A-chain immunotoxin DA7. (1371092)
1992
15
Acute T-cell leukemia/lymphoma mimicking Hodgkin's disease with secondary HTLV I seroconversion. (2208004)
1990
16
Antigen-specific recognition of autologous leukemia cells and allogeneic class-I MHC antigens by IL-2-activated cytotoxic T cells from a patient with acute T-cell leukemia. (2546621)
1989
17
Constitutive expression and abnormal glycosylation of transferrin receptor in acute T-cell leukemia. (2582441)
1989
18
A case of CD3+, CD4-, CD8-, WT31- acute T-cell leukemia. (2787596)
1989
19
Cyclosporine A and acute T cell leukemia in the rat. (3164536)
1988
20
Childhood primary cutaneous non-T/non-B lymphoma followed by acute T-cell leukemia. (3486034)
1986
21
T-lymphoblasts with erythropoietic helper function in acute T-cell leukemia. (2978965)
1986
22
t(11;19)(q23;p11) in a child with acute T-cell leukemia. (3855377)
1985
23
Human serum thymic factor in detecting acute T cell leukemia. (311636)
1978

Variations for Acute T Cell Leukemia

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Expression for genes affiliated with Acute T Cell Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute T Cell Leukemia

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Pathways for genes affiliated with Acute T Cell Leukemia

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51PathCards, 39NCBI BioSystems Database, 55R&D Systems
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Pathways related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NOTCH1, MYB
29.7NOTCH1, MYB
39.6NOTCH1, PICALM

Compounds for genes affiliated with Acute T Cell Leukemia

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46Novoseek, 62Tocris Bioscience
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Compounds related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1leptomycin b46 6210.3LPP, NUP214

GO Terms for genes affiliated with Acute T Cell Leukemia

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17Gene Ontology
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Cellular components related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.9NOTCH1, LPP, LMO2, LMO1, HSD17B1, NUP214

Biological processes related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thymus developmentGO:0485389.7MYB, LMO4
2axonogenesisGO:0074099.5PICALM, NOTCH1
3negative regulation of transcription from RNA polymerase II promoterGO:0001229.2NOTCH1, MYB, LMO1
4positive regulation of transcription, DNA-templatedGO:0458939.0NOTCH1, MYB, PICALM
5positive regulation of transcription from RNA polymerase II promoterGO:0459448.3NOTCH1, MYB, LMO4, LMO2, LMO1

Molecular functions related to Acute T Cell Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionGO:0011909.3NOTCH1, LMO2
2zinc ion bindingGO:0082708.2LPP, LMO4, LMO2, LMO1

Products for genes affiliated with Acute T Cell Leukemia

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Sources for Acute T Cell Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet