MCID: ACT159
MIFTS: 42

Acute Transverse Myelitis malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Transverse Myelitis

Aliases & Descriptions for Acute Transverse Myelitis:

Name: Acute Transverse Myelitis 56
Myelitis, Acute Transverse 69

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA139417
UMLS via Orphanet 70 C0270627
ICD10 via Orphanet 34 G37.3

Summaries for Acute Transverse Myelitis

MalaCards based summary : Acute Transverse Myelitis, also known as myelitis, acute transverse, is related to hepatitis and neuropathy. An important gene associated with Acute Transverse Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Interferon beta-1a and interferons have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related phenotypes are cardiovascular system and neoplasm

Related Diseases for Acute Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Acute Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
id Related Disease Score Top Affiliating Genes
1 hepatitis 30.0 IL10 IL6
2 neuropathy 29.5 CXCL8 IL6
3 idiopathic acute transverse myelitis 12.4
4 secondary acute transverse myelitis 12.2
5 myelitis 10.9
6 transverse myelitis 10.9
7 hypersensitivity reaction type iii disease 10.2 CXCL8 MMP9
8 conidiobolomycosis 10.2 CXCL8 IL10
9 inflammatory bowel disease 20 10.2 CXCL8 IL10
10 microglandular adenosis of breast 10.2 CXCL8 IL10
11 coronary arterial fistulas 10.2 CXCL8 IL10
12 hidradenitis suppurativa 10.2 CXCL8 IL10
13 middle lobe syndrome 10.2 CXCL8 IL10
14 autoimmune polyendocrine syndrome type 1 10.2 CXCL8 MMP9
15 plantar wart 10.2 CXCL8 IL10
16 parkinson disease 11 10.2 CXCL8 IL10
17 oculomotor nerve paralysis 10.1 CXCL8 IL6
18 common peroneal nerve lesion 10.1 CXCL8 IL6
19 thymic neuroendocrine carcinoma 10.1 CXCL8 IL6
20 psychotic disorder 10.1 CXCL8 IL6
21 omsk hemorrhagic fever 10.1 CXCL8 MMP9
22 schwannoma of ureter 10.1 CXCL8 IL6
23 retinal vascular disease 10.1 CXCL8 IL6
24 acute panmyelosis with myelofibrosis 10.1 CXCL8 IL6
25 senile reticular retinal degeneration 10.1 CXCL8 IL10
26 labyrinthine bilateral reactive loss 10.1 CXCL8 IL6
27 esophagus lymphoma 10.1 CXCL8 IL6
28 joint disorders 10.1 APOA1 IL6
29 ureter inverted papilloma 10.1 IL10 IL6
30 larynx carcinoma in situ 10.1 CXCL8 IL6
31 bullous retinoschisis 10.1 CXCL8 IL6
32 carbuncle 10.1 CXCL8 IL6
33 transient tic disorder 10.1 IL10 IL6
34 stomatitis 10.1 CXCL8 IL6
35 vitreoretinopathy, neovascular inflammatory 10.1 CXCL8 IL6
36 larynx leiomyoma 10.1 CXCL8 IL6
37 reproductive system disease 10.1 IL10 IL6
38 cicatricial lagophthalmos 10.1 CXCL8 IL6
39 lepromatous leprosy 10.1 IL10 IL6
40 cyclosporiasis 10.1 IL10 IL6
41 polyneuropathy in collagen vascular disease 10.1 IL6 MMP9
42 lateral cystocele 10.1 CXCL8 IL6
43 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL10 IL6
44 histiocytoma 10.1 CXCL8 MMP9
45 acquired thrombocytopenia 10.1 CXCL8 IL6
46 phlyctenulosis 10.1 IL10 IL6
47 encephalitis 10.1
48 systemic lupus erythematosus 10.1
49 lupus erythematosus 10.1
50 multiple mitochondrial dysfunctions syndrome 10.1 IL10 IL6

Graphical network of the top 20 diseases related to Acute Transverse Myelitis:



Diseases related to Acute Transverse Myelitis

Symptoms & Phenotypes for Acute Transverse Myelitis

MGI Mouse Phenotypes related to Acute Transverse Myelitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 APOA1 AQP4 IL10 IL6 MMP2 MMP9
2 neoplasm MP:0002006 9.46 IL10 IL6 MMP2 MMP9
3 respiratory system MP:0005388 9.35 AQP4 IL10 IL6 MMP2 MMP9
4 vision/eye MP:0005391 9.02 AQP4 IL10 IL6 MMP2 MMP9

Drugs & Therapeutics for Acute Transverse Myelitis

Drugs for Acute Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
2 interferons Phase 4
3 Adjuvants, Immunologic Phase 4
4 Anti-Infective Agents Phase 4
5 Interferon-beta Phase 4
6 Antiviral Agents Phase 4
7
Prednisolone Approved, Vet_approved Phase 3,Phase 1 50-24-8 5755
8
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1 83-43-2 6741
9 Prednisolone acetate Phase 3,Phase 1
10 glucocorticoids Phase 3,Phase 1
11 Gastrointestinal Agents Phase 3,Phase 1
12 Neuroprotective Agents Phase 3,Phase 1
13 Hormone Antagonists Phase 3,Phase 1
14 Hormones Phase 3,Phase 1
15 Peripheral Nervous System Agents Phase 3,Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
17 Prednisolone hemisuccinate Phase 3,Phase 1
18 Prednisolone phosphate Phase 3,Phase 1
19 Protective Agents Phase 3,Phase 1
20 Antiemetics Phase 3,Phase 1
21 Anti-Inflammatory Agents Phase 3,Phase 1
22 Methylprednisolone acetate Phase 3,Phase 1
23 Methylprednisolone Hemisuccinate Phase 3,Phase 1
24 Autonomic Agents Phase 3,Phase 1
25
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
26
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
27
Mesna Approved Phase 1, Phase 2 3375-50-6 598
28 Immunosuppressive Agents Phase 1, Phase 2
29
Bevacizumab Approved, Investigational Phase 1 216974-75-3
30
protease inhibitors Phase 1
31 Serine Proteinase Inhibitors Phase 1
32 Alpha 1-Antitrypsin Phase 1
33 HIV Protease Inhibitors Phase 1
34 Trypsin Inhibitors Phase 1
35 Protein C Phase 1
36 Protein C Inhibitor Phase 1
37 Antineoplastic Agents, Hormonal Phase 1
38 Complement C1 Inactivator Proteins Phase 1
39 Complement C1 Inhibitor Protein Phase 1
40 Complement C1s Phase 1
41 Complement Inactivating Agents Phase 1
42 Complement System Proteins Phase 1
43 Angiogenesis Inhibitors Phase 1
44 Angiogenesis Modulating Agents Phase 1
45 Immunoglobulins Phase 1
46 Antibodies Phase 1
47 Antirheumatic Agents Phase 1
48 Antibodies, Monoclonal Phase 1
49 serine Nutraceutical Phase 1

Interventional clinical trials:

(show all 11)
id Name Status NCT ID Phase
1 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 Hematopoietic Stem Cell Transplant in Devic's Disease Recruiting NCT00787722 Phase 1, Phase 2
4 Pilot Study of alpha1-antitrypsin to Treat Neuromyelitis Optica Relapses Unknown status NCT02087813 Phase 1
5 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1
6 Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations Completed NCT01777412 Phase 1
7 C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation Completed NCT01759602 Phase 1
8 Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Active, not recruiting NCT02276963 Phase 1
9 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Recruiting NCT02144935
10 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Recruiting NCT03122873
11 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367

Search NIH Clinical Center for Acute Transverse Myelitis

Genetic Tests for Acute Transverse Myelitis

Anatomical Context for Acute Transverse Myelitis

MalaCards organs/tissues related to Acute Transverse Myelitis:

39
Spinal Cord, Brain, Testes, Skin, Pancreas, Kidney, Thyroid

Publications for Acute Transverse Myelitis

Articles related to Acute Transverse Myelitis:

(show top 50) (show all 190)
id Title Authors Year
1
A pediatric patient of hemorrhagic acute transverse myelitis. ( 27686688 )
2016
2
Elevated Lipid Profiles in Patients with Acute Transverse Myelitis. ( 26949935 )
2016
3
An unusual case of acute transverse myelitis caused by HSV-1 infection. ( 27419072 )
2016
4
Rehabilitation of a patient with overlap of acute transverse myelitis and Bickerstaff's brainstem encephalitis: a case report. ( 28053734 )
2016
5
Acute transverse myelitis of the cervical spine secondary to psoas abscess. ( 27756229 )
2016
6
Acute Transverse Myelitis and Nicolau Syndrome after Benzathine Penicillin Injection. ( 27762530 )
2016
7
Acute Transverse Myelitis Associated with Salmonella Bacteremia: A Case Report. ( 27928148 )
2016
8
Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. ( 27645347 )
2016
9
Acute transverse myelitis in childhood: A single centre experience from North India. ( 26924166 )
2016
10
Concurrency of Guillain-Barre syndrome and acute transverse myelitis: a case report and review of literature. ( 28018472 )
2016
11
Neurological and functional recovery in acute transverse myelitis patients with inpatient rehabilitation and magnetic resonance imaging correlates. ( 26927295 )
2016
12
Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review. ( 27703498 )
2016
13
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysis. ( 26608499 )
2016
14
Concomitant acute transverse myelitis and sensory motor axonal polyneuropathy in two children: two case reports. ( 25750885 )
2015
15
Idiopathic Acute Transverse Myelitis in Children: A Retrospective Series. ( 26267704 )
2015
16
Diagnostic transcranial magnetic stimulation as a prognostic tool in children with acute transverse myelitis. ( 26238314 )
2015
17
Clinical insights for early detection of acute transverse myelitis in the emergency department. ( 27752572 )
2015
18
Acute transverse myelitis associated with human parvovirus b19 infection. ( 24049056 )
2014
19
Acute transverse myelitis and psoriasiform dermatitis associated with Sjoegren's syndrome: a case report. ( 25167870 )
2014
20
Acute transverse myelitis during treatment with etanercept for severe plaque psoriasis. ( 24355280 )
2014
21
Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. ( 25117654 )
2014
22
Acute transverse myelitis as the first clinical manifestation of systemic lupus erythematosus. ( 25591708 )
2014
23
Acute transverse myelitis complicating breakthrough varicella infection. ( 24853543 )
2014
24
Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse myelitis. ( 25221410 )
2014
25
Acute transverse myelitis: a rare neurological complication following wasp sting. ( 24608473 )
2014
26
The value of 3-T magnetic resonance imaging in acute transverse myelitis. ( 25444094 )
2014
27
Partial acute transverse myelitis is a predictor of multiple sclerosis in children. ( 24619933 )
2014
28
Co-existence of acute transverse myelitis and Guillain-BarrAc syndrome associated with Bartonella henselae infection. ( 23930734 )
2013
29
Prognostic indicators of acute transverse myelitis in 39 children. ( 24112847 )
2013
30
Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis. ( 23329376 )
2013
31
Acute Transverse Myelitis Associated with Buserelin Use during IVF. ( 23607013 )
2013
32
Acute transverse myelitis after thoracic epidural anesthesia and analgesia: should anesthesia and analgesia be blamed? ( 23711605 )
2013
33
Distinct serum apolipoprotein A-I levels in neuromyelitis optica and acute transverse myelitis. ( 24148653 )
2013
34
Bacillus thuringiensis poisoning related acute transverse myelitis. ( 24340786 )
2013
35
Acute transverse myelitis in a child with Lyme disease and a review of literature. ( 23498570 )
2013
36
Idiopathic acute transverse myelitis: outcome and conversion to multiple sclerosis in a large series. ( 24090445 )
2013
37
Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis. ( 23935366 )
2013
38
Acute transverse myelitis (ascending myelitis) as the initial manifestation of Japanese encephalitis: a rare presentation. ( 23585973 )
2013
39
An acute transverse myelitis attack after total body irradiation: a rare case. ( 23984124 )
2013
40
Idiopathic acute transverse myelitis: Complete recovery after intravenous immunoglobulin. ( 23935301 )
2012
41
Pediatric acute transverse myelitis overview and differential diagnosis. ( 22914370 )
2012
42
Acute transverse myelitis as a rare manifestation of Campylobacter diarrhoea with concomitant disruption of the blood brain barrier. ( 22133816 )
2012
43
Acute transverse myelitis: an unusual complication of typhoid fever. ( 22824669 )
2012
44
Anti-AQP(4) antibody in idiopathic acute transverse myelitis with recurrent clinical course: frequency of positivity and influence in prognosis. ( 22925751 )
2012
45
Diagnosis and treatment of pediatric acute transverse myelitis. ( 23814937 )
2012
46
Initial presentation of acute transverse myelitis in systemic lupus erythematosus: demographics, diagnosis, management and comparison to idiopathic cases. ( 21833518 )
2012
47
Acute transverse myelitis: demyelinating, inflammatory, and infectious myelopathies. ( 22961185 )
2012
48
Acute transverse myelitis following Japanese encephalitis viral infection: an uncommon complication of a common disease. ( 23008381 )
2012
49
Treatment of acute transverse myelitis and its early complications. ( 22810928 )
2011
50
Idiopathic acute transverse myelitis in children: an analysis and discussion of MRI findings. ( 20858691 )
2011

Variations for Acute Transverse Myelitis

Expression for Acute Transverse Myelitis

Search GEO for disease gene expression data for Acute Transverse Myelitis.

Pathways for Acute Transverse Myelitis

Pathways related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CXCL8 IL10 IL6 MMP2 MMP9
2
Show member pathways
12.69 CXCL8 IL10 IL6 MMP9
3 12.48 CXCL8 IL6 MMP2 MMP9
4
Show member pathways
12.38 IL10 IL6 MMP2
5
Show member pathways
12.15 CXCL8 IL6 MMP9
6 12.05 CXCL8 IL6 MMP9
7 12 IL6 MMP2 MMP9
8
Show member pathways
11.98 CXCL8 IL10 IL6
9 11.92 AQP4 CXCL8 IL10 IL6
10 11.75 CXCL8 IL6 MMP2
11 11.75 AQP4 CXCL8 IL6 MMP9
12 11.73 CXCL8 IL10 IL6
13 11.63 CXCL8 MMP2 MMP9
14 11.6 CXCL8 IL10 IL6
15 11.58 CXCL8 MMP2 MMP9
16 11.49 CXCL8 MMP2 MMP9
17 11.44 CXCL8 IL6 MMP2 MMP9
18 11.43 CXCL8 IL6 MMP2
19 11.38 CXCL8 IL6
20 11.37 IL6 MMP2
21 11.36 CXCL8 IL10 IL6
22 11.36 CXCL8 IL6 MMP2 MMP9
23 11.34 CXCL8 IL10 IL6
24
Show member pathways
11.32 MMP2 MMP9
25 11.31 IL6 MMP2 MMP9
26
Show member pathways
11.26 CXCL8 IL6 MMP2 MMP9
27 11.2 MMP2 MMP9
28 11.2 IL10 IL6
29 11.17 CXCL8 MMP2
30 11.15 APOA1 IL10 IL6
31 11.12 IL10 IL6
32 11.08 CXCL8 IL10 IL6 MMP2 MMP9
33 11.05 MMP2 MMP9
34 11.05 MMP2 MMP9
35 11.03 CXCL8 IL10 IL6
36 10.89 CXCL8 IL6
37 10.79 CXCL8 IL6 MMP2 MMP9

GO Terms for Acute Transverse Myelitis

Cellular components related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOA1 CXCL8 IL10 IL6 MMP2 MMP9
2 extracellular space GO:0005615 9.1 APOA1 CXCL8 IL10 IL6 MMP2 MMP9

Biological processes related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.69 APOA1 IL10 IL6
2 cellular protein metabolic process GO:0044267 9.61 APOA1 IL6 MMP2
3 embryo implantation GO:0007566 9.49 MMP2 MMP9
4 cellular response to estradiol stimulus GO:0071392 9.48 IL10 IL6
5 endodermal cell differentiation GO:0035987 9.46 MMP2 MMP9
6 cellular response to lipopolysaccharide GO:0071222 9.43 CXCL8 IL10 IL6
7 defense response to protozoan GO:0042832 9.4 IL10 IL6
8 cellular response to hepatocyte growth factor stimulus GO:0035729 9.37 IL10 IL6
9 response to molecule of bacterial origin GO:0002237 9.32 CXCL8 IL10
10 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.16 APOA1 IL10
11 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 APOA1 IL10
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 IL10 MMP2 MMP9

Molecular functions related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL6

Sources for Acute Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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