MCID: ACT159
MIFTS: 45

Acute Transverse Myelitis

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Acute Transverse Myelitis

MalaCards integrated aliases for Acute Transverse Myelitis:

Name: Acute Transverse Myelitis 55
Myelitis, Acute Transverse 69

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA139417
UMLS via Orphanet 70 C0270627
ICD10 via Orphanet 33 G37.3
UMLS 69 C0270627

Summaries for Acute Transverse Myelitis

MalaCards based summary : Acute Transverse Myelitis, also known as myelitis, acute transverse, is related to myelitis and acute disseminated encephalomyelitis. An important gene associated with Acute Transverse Myelitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Prednisolone and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, thyroid and brain, and related phenotypes are cardiovascular system and neoplasm

Related Diseases for Acute Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Acute Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 myelitis 30.9 AQP4 IL6 MMP2
2 acute disseminated encephalomyelitis 30.3 AQP4 IL10
3 neuromyelitis optica 29.9 AQP4 IL6
4 pneumonia 29.6 CXCL8 IL10 IL6
5 demyelinating disease 29.4 AQP4 IL10 MMP9
6 cytomegalovirus infection 29.3 CXCL8 IL10 IL6
7 osteomyelitis 29.3 CXCL8 IL10 IL6
8 chlamydia 29.3 CXCL8 IL10 IL6
9 multiple sclerosis 29.0 AQP4 IL10 IL6 MMP9
10 transverse myelitis 28.8 APOA1 AQP4 CXCL8 IL10 IL6 MMP2
11 arthritis 28.6 CXCL8 IL10 IL6 MMP9
12 idiopathic acute transverse myelitis 12.5
13 secondary acute transverse myelitis 12.4
14 tungiasis 10.3 CXCL8 IL10
15 scabies 10.3 CXCL8 IL10
16 pouchitis 10.3 CXCL8 IL10
17 vulvovaginitis 10.3 CXCL8 IL10
18 necatoriasis 10.3 CXCL8 IL10
19 trichuriasis 10.3 CXCL8 IL10
20 clonorchiasis 10.3 CXCL8 IL10
21 retinitis pigmentosa 44 10.3 CXCL8 IL10
22 aseptic meningitis 10.3 CXCL8 IL10
23 septic arthritis 10.3 CXCL8 MMP2
24 primary peritoneal carcinoma 10.3 CXCL8 IL10
25 vibratory urticaria 10.2 CXCL8 MMP9
26 nasal cavity disease 10.2 CXCL8 IL10
27 cryptogenic organizing pneumonia 10.2 CXCL8 MMP9
28 nose disease 10.2 CXCL8 IL10
29 periodontosis 10.2 CXCL8 MMP9
30 tuberculous meningitis 10.2 CXCL8 MMP9
31 systemic lupus erythematosus 10.2
32 lupus erythematosus 10.2
33 peptic ulcer disease 10.2 CXCL8 IL10
34 upper respiratory tract disease 10.2 CXCL8 IL10
35 extracranial arteriovenous malformation 10.1 MMP2 MMP9
36 encephalitis 10.1
37 hepatitis 10.1
38 shigellosis 10.1 CXCL8 IL10
39 focal myositis 10.1 MMP2 MMP9
40 spastic entropion 10.1 MMP2 MMP9
41 lentigo maligna melanoma 10.1 MMP2 MMP9
42 villous adenocarcinoma 10.1 MMP2 MMP9
43 psammomatous meningioma 10.1 MMP2 MMP9
44 senile ectropion 10.1 MMP2 MMP9
45 internal hemorrhoid 10.1 MMP2 MMP9
46 parotitis 10.1 MMP2 MMP9
47 light chain deposition disease 10.1 MMP2 MMP9
48 conjunctival nevus 10.1 MMP2 MMP9
49 microcystic meningioma 10.1 MMP2 MMP9
50 klatskin's tumor 10.1 MMP2 MMP9

Graphical network of the top 20 diseases related to Acute Transverse Myelitis:



Diseases related to Acute Transverse Myelitis

Symptoms & Phenotypes for Acute Transverse Myelitis

MGI Mouse Phenotypes related to Acute Transverse Myelitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 MMP9 APOA1 AQP4 IL10 IL6 MMP2
2 neoplasm MP:0002006 9.46 IL10 IL6 MMP2 MMP9
3 respiratory system MP:0005388 9.35 AQP4 IL10 IL6 MMP2 MMP9
4 vision/eye MP:0005391 9.02 AQP4 IL10 IL6 MMP2 MMP9

Drugs & Therapeutics for Acute Transverse Myelitis

Drugs for Acute Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
3 Prednisolone acetate Phase 3
4 glucocorticoids Phase 3
5 Methylprednisolone acetate Phase 3
6 Methylprednisolone Hemisuccinate Phase 3
7 Gastrointestinal Agents Phase 3
8 Neuroprotective Agents Phase 3
9 Hormone Antagonists Phase 3
10 Hormones Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Antiemetics Phase 3
14 Prednisolone hemisuccinate Phase 3
15 Prednisolone phosphate Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Protective Agents Phase 3
18 Autonomic Agents Phase 3
19
rituximab Approved Phase 1 174722-31-7 10201696
20 Immunoglobulins Phase 1
21 Antibodies Phase 1
22 Antirheumatic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1 Rituximab

Search NIH Clinical Center for Acute Transverse Myelitis

Genetic Tests for Acute Transverse Myelitis

Anatomical Context for Acute Transverse Myelitis

MalaCards organs/tissues related to Acute Transverse Myelitis:

38
Spinal Cord, Thyroid, Brain, Testes, Skin, Pancreas, Kidney

Publications for Acute Transverse Myelitis

Articles related to Acute Transverse Myelitis:

(show top 50) (show all 202)
# Title Authors Year
1
Acute Transverse Myelitis Caused by Echovirus 11 in a Pediatric Patient: Case Report and Review of the Current Literature. ( 29372173 )
2018
2
Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus. ( 29294596 )
2018
3
Acute transverse myelitis following scrub typhus: A case report and review of the literature. ( 29350608 )
2018
4
Spinal Cord Infarction Mimicking Acute Transverse Myelitis. ( 29441246 )
2017
5
Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome. ( 28149080 )
2017
6
Acute transverse myelitis in a pediatric patient. ( 28215959 )
2017
7
Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings. ( 28115665 )
2017
8
A rare case of acute transverse myelitis associated with Staphylococcusaureus bacteremia and osteomyelitis. ( 28584662 )
2017
9
Pediatric acute transverse myelitis. ( 28678221 )
2017
10
Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis. ( 28240719 )
2017
11
A child with acute transverse myelitis requiring permanent pacemaker implantation. ( 28551037 )
2017
12
Hepatitis B virus induced cytoplasmic antineutrophil cytoplasmic antibody-mediated vasculitis causing subarachnoid hemorrhage, acute transverse myelitis, and nephropathy: a case report. ( 28366165 )
2017
13
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysis. ( 26608499 )
2016
14
Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review. ( 27703498 )
2016
15
A pediatric patient of hemorrhagic acute transverse myelitis. ( 27686688 )
2016
16
Concurrency of Guillain-Barre syndrome and acute transverse myelitis: a case report and review of literature. ( 28018472 )
2016
17
Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. ( 27645347 )
2016
18
Neurological and functional recovery in acute transverse myelitis patients with inpatient rehabilitation and magnetic resonance imaging correlates. ( 26927295 )
2016
19
Acute Transverse Myelitis Associated with Salmonella Bacteremia: A Case Report. ( 27928148 )
2016
20
Elevated Lipid Profiles in Patients with Acute Transverse Myelitis. ( 26949935 )
2016
21
Acute Transverse Myelitis and Nicolau Syndrome after Benzathine Penicillin Injection. ( 27762530 )
2016
22
Rehabilitation of a patient with overlap of acute transverse myelitis and Bickerstaff's brainstem encephalitis: a case report. ( 28053734 )
2016
23
Acute transverse myelitis in childhood: A single centre experience from North India. ( 26924166 )
2016
24
Acute transverse myelitis of the cervical spine secondary to psoas abscess. ( 27756229 )
2016
25
An unusual case of acute transverse myelitis caused by HSV-1 infection. ( 27419072 )
2016
26
Concomitant acute transverse myelitis and sensory motor axonal polyneuropathy in two children: two case reports. ( 25750885 )
2015
27
Idiopathic Acute Transverse Myelitis in Children: A Retrospective Series. ( 26267704 )
2015
28
Clinical insights for early detection of acute transverse myelitis in the emergency department. ( 27752572 )
2015
29
Diagnostic transcranial magnetic stimulation as a prognostic tool in children with acute transverse myelitis. ( 26238314 )
2015
30
Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse myelitis. ( 25221410 )
2014
31
Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. ( 25117654 )
2014
32
The value of 3-T magnetic resonance imaging in acute transverse myelitis. ( 25444094 )
2014
33
Partial acute transverse myelitis is a predictor of multiple sclerosis in children. ( 24619933 )
2014
34
Acute transverse myelitis as the first clinical manifestation of systemic lupus erythematosus. ( 25591708 )
2014
35
Acute transverse myelitis associated with human parvovirus b19 infection. ( 24049056 )
2014
36
Acute transverse myelitis complicating breakthrough varicella infection. ( 24853543 )
2014
37
Acute transverse myelitis during treatment with etanercept for severe plaque psoriasis. ( 24355280 )
2014
38
Acute transverse myelitis and psoriasiform dermatitis associated with Sjoegren's syndrome: a case report. ( 25167870 )
2014
39
Acute transverse myelitis: a rare neurological complication following wasp sting. ( 24608473 )
2014
40
Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis. ( 23935366 )
2013
41
Distinct serum apolipoprotein A-I levels in neuromyelitis optica and acute transverse myelitis. ( 24148653 )
2013
42
An acute transverse myelitis attack after total body irradiation: a rare case. ( 23984124 )
2013
43
Bacillus thuringiensis poisoning related acute transverse myelitis. ( 24340786 )
2013
44
Acute transverse myelitis in a child with Lyme disease and a review of literature. ( 23498570 )
2013
45
Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis. ( 23329376 )
2013
46
Prognostic indicators of acute transverse myelitis in 39 children. ( 24112847 )
2013
47
Idiopathic acute transverse myelitis: outcome and conversion to multiple sclerosis in a large series. ( 24090445 )
2013
48
Acute transverse myelitis after thoracic epidural anesthesia and analgesia: should anesthesia and analgesia be blamed? ( 23711605 )
2013
49
Acute transverse myelitis (ascending myelitis) as the initial manifestation of Japanese encephalitis: a rare presentation. ( 23585973 )
2013
50
Acute Transverse Myelitis Associated with Buserelin Use during IVF. ( 23607013 )
2013

Variations for Acute Transverse Myelitis

Expression for Acute Transverse Myelitis

Search GEO for disease gene expression data for Acute Transverse Myelitis.

Pathways for Acute Transverse Myelitis

Pathways related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CXCL8 IL10 IL6 MMP2 MMP9
2 12.62 CXCL8 IL6 MMP2 MMP9
3
Show member pathways
12.38 IL10 IL6 MMP2
4
Show member pathways
12.36 CXCL8 IL6 MMP9
5
Show member pathways
12.32 CXCL8 IL10 IL6
6
Show member pathways
12.15 CXCL8 IL6 MMP9
7 12.06 CXCL8 IL6 MMP9
8 12 IL6 MMP2 MMP9
9
Show member pathways
11.97 CXCL8 IL10 IL6
10 11.92 AQP4 CXCL8 IL10 IL6
11 11.75 CXCL8 IL6 MMP2
12 11.75 AQP4 CXCL8 IL6 MMP9
13 11.73 CXCL8 IL10 IL6
14 11.63 CXCL8 MMP2 MMP9
15 11.6 CXCL8 IL10 IL6
16 11.58 CXCL8 MMP2 MMP9
17 11.49 CXCL8 MMP2 MMP9
18 11.44 CXCL8 IL6 MMP2 MMP9
19 11.43 CXCL8 IL6 MMP2
20 11.38 CXCL8 IL6
21 11.38 IL6 MMP2
22 11.36 CXCL8 IL10 IL6
23 11.36 CXCL8 IL6 MMP2 MMP9
24 11.34 CXCL8 IL10 IL6
25
Show member pathways
11.32 MMP2 MMP9
26 11.31 IL6 MMP2 MMP9
27
Show member pathways
11.26 CXCL8 IL6 MMP2 MMP9
28 11.2 IL10 IL6
29 11.17 CXCL8 MMP2
30 11.15 MMP2 MMP9
31 11.15 APOA1 IL10 IL6
32 11.12 IL10 IL6
33 11.08 CXCL8 IL10 IL6 MMP2 MMP9
34 11.05 MMP2 MMP9
35 11.03 CXCL8 IL10 IL6
36 10.99 MMP2 MMP9
37 10.89 CXCL8 IL6
38 10.79 CXCL8 IL6 MMP2 MMP9

GO Terms for Acute Transverse Myelitis

Cellular components related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOA1 CXCL8 IL10 IL6 MMP2 MMP9
2 extracellular matrix GO:0031012 9.33 APOA1 MMP2 MMP9
3 extracellular space GO:0005615 9.1 APOA1 CXCL8 IL10 IL6 MMP2 MMP9

Biological processes related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 APOA1 IL6 MMP2
2 embryo implantation GO:0007566 9.43 MMP2 MMP9
3 cellular response to lipopolysaccharide GO:0071222 9.43 CXCL8 IL10 IL6
4 endodermal cell differentiation GO:0035987 9.4 MMP2 MMP9
5 response to molecule of bacterial origin GO:0002237 9.32 CXCL8 IL10
6 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.16 APOA1 IL10
7 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 APOA1 IL10
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 IL10 MMP2 MMP9

Molecular functions related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL6

Sources for Acute Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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