MCID: ACT159
MIFTS: 42

Acute Transverse Myelitis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Acute Transverse Myelitis

MalaCards integrated aliases for Acute Transverse Myelitis:

Name: Acute Transverse Myelitis 56
Myelitis, Acute Transverse 69

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA139417
UMLS via Orphanet 70 C0270627
ICD10 via Orphanet 34 G37.3

Summaries for Acute Transverse Myelitis

MalaCards based summary : Acute Transverse Myelitis, also known as myelitis, acute transverse, is related to myelitis and influenza. An important gene associated with Acute Transverse Myelitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Interferon beta-1a and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, thyroid and brain, and related phenotypes are cardiovascular system and neoplasm

Related Diseases for Acute Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis Secondary Acute Transverse Myelitis

Diseases related to Acute Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
id Related Disease Score Top Affiliating Genes
1 myelitis 30.5 IL10 IL6 MMP9
2 influenza 30.2 MMP2 MMP9
3 idiopathic acute transverse myelitis 12.4
4 secondary acute transverse myelitis 12.2
5 transverse myelitis 10.9
6 basidiobolomycosis 10.5 CXCL8 IL10
7 lymph node palisaded myofibroblastoma 10.5 CXCL8 IL10
8 congenital insensitivity to pain with hyperhidrosis 10.5 CXCL8 IL10
9 hidradenitis suppurativa 10.5 CXCL8 IL10
10 nonspecific interstitial pneumonia 10.5 CXCL8 IL10
11 tarsal tunnel syndrome 10.5 CXCL8 IL10
12 urofacial syndrome 1 10.5 CXCL8 IL10
13 plantar wart 10.5 CXCL8 IL10
14 senile reticular retinal degeneration 10.4 CXCL8 IL10
15 distal monosomy 7q36 10.4 CXCL8 IL10
16 thymus clear cell carcinoma 10.4 CXCL8 MMP2
17 ichthyosis, congenital, autosomal recessive 12 10.4 CXCL8 MMP9
18 eyelid neoplasm 10.4 CXCL8 IL10
19 tuberculous salpingitis 10.4 CXCL8 MMP9
20 follicular mucinosis 10.4 CXCL8 MMP9
21 dehydration polycythemia 10.3 CXCL8 IL10
22 tumefactive multiple sclerosis 10.3 CXCL8 MMP9
23 myopathy 10.3 CXCL8 MMP9
24 extrahepatic bile duct papillary adenoma 10.3 CXCL8 IL10
25 pelvic varices 10.3 CXCL8 IL10
26 facial arteriovenous malformation 10.3 MMP2 MMP9
27 familial short qt syndrome 10.3 MMP2 MMP9
28 kleptomania 10.3 MMP2 MMP9
29 leucocyte adhesion defect 10.3 MMP2 MMP9
30 acquired hemangioma 10.3 MMP2 MMP9
31 transitional meningioma 10.3 MMP2 MMP9
32 tinea profunda 10.2 MMP2 MMP9
33 xanthogranulomatous cholecystitis 10.2 MMP2 MMP9
34 collagenous colitis 10.2 MMP2 MMP9
35 sialadenitis 10.2 MMP2 MMP9
36 cecum adenoma 10.2 MMP2 MMP9
37 corneal staphyloma 10.2 MMP2 MMP9
38 entropion 10.2 CXCL8 IL10
39 limbic encephalitis 10.2 MMP2 MMP9
40 spindle epithelial tumor with thymus-like differentiation tumor 10.2 MMP2 MMP9
41 nasal cavity adenocarcinoma 10.2 MMP2 MMP9
42 ulnar neuropathy 10.2 MMP2 MMP9
43 adenosine monophosphate deaminase 1 deficiency 10.2 MMP2 MMP9
44 charcot-marie-tooth disease, axonal, type 2cc 10.2 MMP2 MMP9
45 oculomotor nerve paralysis 10.2 CXCL8 IL6
46 colon squamous cell carcinoma 10.2 MMP2 MMP9
47 common peroneal nerve lesion 10.2 CXCL8 IL6
48 oligomeganephronic renal hypoplasia 10.2 MMP2 MMP9
49 spirillary rat-bite fever 10.2 CXCL8 IL6
50 schwannoma of ureter 10.2 CXCL8 IL6

Graphical network of the top 20 diseases related to Acute Transverse Myelitis:



Diseases related to Acute Transverse Myelitis

Symptoms & Phenotypes for Acute Transverse Myelitis

MGI Mouse Phenotypes related to Acute Transverse Myelitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 MMP2 MMP9 APOA1 AQP4 IL10 IL6
2 neoplasm MP:0002006 9.46 MMP2 MMP9 IL10 IL6
3 respiratory system MP:0005388 9.35 MMP9 AQP4 IL10 IL6 MMP2
4 vision/eye MP:0005391 9.02 MMP2 MMP9 AQP4 IL10 IL6

Drugs & Therapeutics for Acute Transverse Myelitis

Drugs for Acute Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
2 Adjuvants, Immunologic Phase 4
3 Anti-Infective Agents Phase 4
4 Antiviral Agents Phase 4
5 Interferon-beta Phase 4
6 interferons Phase 4
7
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 3,Phase 1 50-24-8 5755
9 Antiemetics Phase 3,Phase 1
10 Anti-Inflammatory Agents Phase 3,Phase 1
11 Autonomic Agents Phase 3,Phase 1
12 Gastrointestinal Agents Phase 3,Phase 1
13 glucocorticoids Phase 3,Phase 1
14 Hormone Antagonists Phase 3,Phase 1
15 Hormones Phase 3,Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
17 Methylprednisolone acetate Phase 3,Phase 1
18 Methylprednisolone Hemisuccinate Phase 3,Phase 1
19 Neuroprotective Agents Phase 3,Phase 1
20 Peripheral Nervous System Agents Phase 3,Phase 1
21 Prednisolone acetate Phase 3,Phase 1
22 Prednisolone hemisuccinate Phase 3,Phase 1
23 Prednisolone phosphate Phase 3,Phase 1
24 Protective Agents Phase 3,Phase 1
25
Protein C Approved Phase 1
26
rituximab Approved Phase 1 174722-31-7 10201696
27
Bevacizumab Approved, Investigational Phase 1 216974-75-3
28 Alpha 1-Antitrypsin Phase 1
29 Antineoplastic Agents, Hormonal Phase 1
30 HIV Protease Inhibitors Phase 1
31
protease inhibitors Phase 1
32 Protein C Inhibitor Phase 1
33 Serine Proteinase Inhibitors Phase 1
34 Trypsin Inhibitors Phase 1
35 Antibodies Phase 1
36 Antirheumatic Agents Phase 1
37 Immunoglobulins Phase 1
38 Angiogenesis Inhibitors Phase 1
39 Angiogenesis Modulating Agents Phase 1
40 Complement C1 Inactivator Proteins Phase 1
41 Complement C1 Inhibitor Protein Phase 1
42 Complement C1s Phase 1
43 Complement Inactivating Agents Phase 1
44 Complement System Proteins Phase 1
45 Immunosuppressive Agents Phase 1
46 Antibodies, Monoclonal Phase 1
47 serine Nutraceutical Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
2 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
3 Pilot Study of alpha1-antitrypsin to Treat Neuromyelitis Optica Relapses Unknown status NCT02087813 Phase 1 Alpha1-antitrypsin;methylprednisolone
4 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1 Rituximab
5 Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations Completed NCT01777412 Phase 1 Bevacizumab
6 C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation Completed NCT01759602 Phase 1 C1-esterase inhibitor (Cinryze)
7 Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Active, not recruiting NCT02276963 Phase 1 Ublituximab
8 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Recruiting NCT02144935
9 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367

Search NIH Clinical Center for Acute Transverse Myelitis

Genetic Tests for Acute Transverse Myelitis

Anatomical Context for Acute Transverse Myelitis

MalaCards organs/tissues related to Acute Transverse Myelitis:

39
Spinal Cord, Thyroid, Brain, Testes, Skin, Pancreas, Kidney

Publications for Acute Transverse Myelitis

Articles related to Acute Transverse Myelitis:

(show top 50) (show all 198)
id Title Authors Year
1
Acute transverse myelitis in a pediatric patient. ( 28215959 )
2017
2
Urodynamic profile in acute transverse myelitis patients: Its correlation with neurological outcome. ( 28149080 )
2017
3
A child with acute transverse myelitis requiring permanent pacemaker implantation. ( 28551037 )
2017
4
Hepatitis B virus induced cytoplasmic antineutrophil cytoplasmic antibody-mediated vasculitis causing subarachnoid hemorrhage, acute transverse myelitis, and nephropathy: a case report. ( 28366165 )
2017
5
A rare case of acute transverse myelitis associated with Staphylococcusaureus bacteremia and osteomyelitis. ( 28584662 )
2017
6
Pediatric acute transverse myelitis. ( 28678221 )
2017
7
Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis. ( 28240719 )
2017
8
Successfully Managed Acute Transverse Myelitis Related to Scrub Typhus and Serial Image Findings. ( 28115665 )
2017
9
Concurrency of Guillain-Barre syndrome and acute transverse myelitis: a case report and review of literature. ( 28018472 )
2016
10
Acute transverse myelitis in childhood: A single centre experience from North India. ( 26924166 )
2016
11
Cytokines and matrix metalloproteinases in the cerebrospinal fluid of patients with acute transverse myelitis: an outcome analysis. ( 26608499 )
2016
12
Acute transverse myelitis of the cervical spine secondary to psoas abscess. ( 27756229 )
2016
13
A pediatric patient of hemorrhagic acute transverse myelitis. ( 27686688 )
2016
14
Rehabilitation of a patient with overlap of acute transverse myelitis and Bickerstaff's brainstem encephalitis: a case report. ( 28053734 )
2016
15
Neurological and functional recovery in acute transverse myelitis patients with inpatient rehabilitation and magnetic resonance imaging correlates. ( 26927295 )
2016
16
Specific MRI findings help distinguish acute transverse myelitis of Neuromyelitis Optica from spinal cord infarction. ( 27645347 )
2016
17
Acute transverse myelitis and subacute thyroiditis associated with dengue viral infection: A case report and literature review. ( 27703498 )
2016
18
Acute Transverse Myelitis Associated with Salmonella Bacteremia: A Case Report. ( 27928148 )
2016
19
Elevated Lipid Profiles in Patients with Acute Transverse Myelitis. ( 26949935 )
2016
20
An unusual case of acute transverse myelitis caused by HSV-1 infection. ( 27419072 )
2016
21
Acute Transverse Myelitis and Nicolau Syndrome after Benzathine Penicillin Injection. ( 27762530 )
2016
22
Concomitant acute transverse myelitis and sensory motor axonal polyneuropathy in two children: two case reports. ( 25750885 )
2015
23
Idiopathic Acute Transverse Myelitis in Children: A Retrospective Series. ( 26267704 )
2015
24
Diagnostic transcranial magnetic stimulation as a prognostic tool in children with acute transverse myelitis. ( 26238314 )
2015
25
Clinical insights for early detection of acute transverse myelitis in the emergency department. ( 27752572 )
2015
26
Acute transverse myelitis complicating breakthrough varicella infection. ( 24853543 )
2014
27
Acute transverse myelitis during treatment with etanercept for severe plaque psoriasis. ( 24355280 )
2014
28
Acute transverse myelitis associated with human parvovirus b19 infection. ( 24049056 )
2014
29
Acute transverse myelitis: a rare neurological complication following wasp sting. ( 24608473 )
2014
30
Acute transverse myelitis and psoriasiform dermatitis associated with Sjoegren's syndrome: a case report. ( 25167870 )
2014
31
Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse myelitis. ( 25221410 )
2014
32
Acute transverse myelitis as the first clinical manifestation of systemic lupus erythematosus. ( 25591708 )
2014
33
Systemic lupus erythematosus-associated acute transverse myelitis: manifestations, treatments, outcomes, and prognostic factors in 20 patients. ( 25117654 )
2014
34
Partial acute transverse myelitis is a predictor of multiple sclerosis in children. ( 24619933 )
2014
35
The value of 3-T magnetic resonance imaging in acute transverse myelitis. ( 25444094 )
2014
36
Acute Transverse Myelitis Associated with Buserelin Use during IVF. ( 23607013 )
2013
37
Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis. ( 23935366 )
2013
38
Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis. ( 23329376 )
2013
39
Distinct serum apolipoprotein A-I levels in neuromyelitis optica and acute transverse myelitis. ( 24148653 )
2013
40
Idiopathic acute transverse myelitis: outcome and conversion to multiple sclerosis in a large series. ( 24090445 )
2013
41
An acute transverse myelitis attack after total body irradiation: a rare case. ( 23984124 )
2013
42
Acute transverse myelitis in a child with Lyme disease and a review of literature. ( 23498570 )
2013
43
Bacillus thuringiensis poisoning related acute transverse myelitis. ( 24340786 )
2013
44
Co-existence of acute transverse myelitis and Guillain-BarrAc syndrome associated with Bartonella henselae infection. ( 23930734 )
2013
45
Prognostic indicators of acute transverse myelitis in 39 children. ( 24112847 )
2013
46
Acute transverse myelitis after thoracic epidural anesthesia and analgesia: should anesthesia and analgesia be blamed? ( 23711605 )
2013
47
Acute transverse myelitis (ascending myelitis) as the initial manifestation of Japanese encephalitis: a rare presentation. ( 23585973 )
2013
48
Acute transverse myelitis following Japanese encephalitis viral infection: an uncommon complication of a common disease. ( 23008381 )
2012
49
Initial presentation of acute transverse myelitis in systemic lupus erythematosus: demographics, diagnosis, management and comparison to idiopathic cases. ( 21833518 )
2012
50
Acute transverse myelitis: an unusual complication of typhoid fever. ( 22824669 )
2012

Variations for Acute Transverse Myelitis

Expression for Acute Transverse Myelitis

Search GEO for disease gene expression data for Acute Transverse Myelitis.

Pathways for Acute Transverse Myelitis

Pathways related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 36)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CXCL8 IL10 IL6 MMP2 MMP9
2 12.48 CXCL8 IL6 MMP2 MMP9
3
Show member pathways
12.38 IL10 IL6 MMP2
4
Show member pathways
12.15 CXCL8 IL6 MMP9
5 12.05 CXCL8 IL6 MMP9
6 12 IL6 MMP2 MMP9
7
Show member pathways
11.98 CXCL8 IL10 IL6
8 11.92 AQP4 CXCL8 IL10 IL6
9 11.75 CXCL8 IL6 MMP2
10 11.75 AQP4 CXCL8 IL6 MMP9
11 11.73 CXCL8 IL10 IL6
12 11.63 CXCL8 MMP2 MMP9
13 11.6 CXCL8 IL10 IL6
14 11.58 CXCL8 MMP2 MMP9
15 11.49 CXCL8 MMP2 MMP9
16 11.44 CXCL8 IL6 MMP2 MMP9
17 11.43 CXCL8 IL6 MMP2
18 11.37 CXCL8 IL6
19 11.37 IL6 MMP2
20 11.36 CXCL8 IL10 IL6
21 11.36 CXCL8 IL6 MMP2 MMP9
22 11.34 CXCL8 IL10 IL6
23
Show member pathways
11.31 MMP2 MMP9
24 11.31 IL6 MMP2 MMP9
25
Show member pathways
11.26 CXCL8 IL6 MMP2 MMP9
26 11.2 IL10 IL6
27 11.19 MMP2 MMP9
28 11.17 CXCL8 MMP2
29 11.15 APOA1 IL10 IL6
30 11.12 IL10 IL6
31 11.08 CXCL8 IL10 IL6 MMP2 MMP9
32 11.05 MMP2 MMP9
33 11.04 MMP2 MMP9
34 11.03 CXCL8 IL10 IL6
35 10.89 CXCL8 IL6
36 10.79 CXCL8 IL6 MMP2 MMP9

GO Terms for Acute Transverse Myelitis

Cellular components related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOA1 CXCL8 IL10 IL6 MMP2 MMP9
2 extracellular matrix GO:0031012 9.16 MMP2 MMP9
3 extracellular space GO:0005615 9.1 APOA1 CXCL8 IL10 IL6 MMP2 MMP9

Biological processes related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.69 APOA1 IL10 IL6
2 cellular protein metabolic process GO:0044267 9.61 APOA1 IL6 MMP2
3 embryo implantation GO:0007566 9.49 MMP2 MMP9
4 cellular response to estradiol stimulus GO:0071392 9.48 IL10 IL6
5 endodermal cell differentiation GO:0035987 9.46 MMP2 MMP9
6 cellular response to lipopolysaccharide GO:0071222 9.43 CXCL8 IL10 IL6
7 defense response to protozoan GO:0042832 9.4 IL10 IL6
8 cellular response to hepatocyte growth factor stimulus GO:0035729 9.37 IL10 IL6
9 response to molecule of bacterial origin GO:0002237 9.32 CXCL8 IL10
10 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.16 APOA1 IL10
11 negative regulation of cytokine secretion involved in immune response GO:0002740 8.96 APOA1 IL10
12 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 IL10 MMP2 MMP9

Molecular functions related to Acute Transverse Myelitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL6

Sources for Acute Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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