MCID: ACT140
MIFTS: 33

Acute Undifferentiated Leukemia malady

Blood, Cancer categories

Summaries for Acute Undifferentiated Leukemia

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33MalaCards
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MalaCards: Acute Undifferentiated Leukemia is related to acute leukemia and acute myeloid leukemia. An important gene associated with Acute Undifferentiated Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Stabilization of mRNA by HuR and Transcriptional misregulation in cancer. The compounds alpha-naphthyl butyrate and monochloroacetic acid have been mentioned in the context of this disorder. Affiliated tissues include myeloid, monocytes and nk cells, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Aliases & Classifications for Acute Undifferentiated Leukemia

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Aliases & Descriptions:

acute undifferentiated leukemia 49 61


External Ids:

ICD10 via Orphanet26 C95.0
UMLS via Orphanet62 C0856823

Related Diseases for Acute Undifferentiated Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Acute Undifferentiated Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.3RUNX1, PPP2R4, MPO, ANPEP, TRD, KMT2A
2acute myeloid leukemia30.5NUP214, RUNX1
3acute monocytic leukemia10.1
4acute t cell leukemia10.1
5t-cell leukemia10.1
6thymoma10.1
7acute erythroblastic leukemia10.1
8glucocorticoid resistance10.1
9bilineal acute leukemia10.1
10peritonitis10.0MPO
11sarcoma10.0ANPEP, RUNX1
12ovarian cancer10.0PPP2R4, RUNX1
13myeloid sarcoma10.0KMT2A, ANPEP, MPO
14lymphoblastic lymphoma10.0KMT2A, MPO
15precursor b-cell acute lymphoblastic leukemia10.0MPO, ANPEP, KMT2A
16chronic myelomonocytic leukemia10.0MPO, RUNX1
17newborn respiratory distress syndrome10.0NR3C1, MPO
18monocytic leukemia10.0RUNX1, KMT2A
19acute myeloid leukemia, adult10.0RUNX1, KMT2A
20adenocarcinoma10.0KMT2A, ANPEP, NR3C1
21retinoblastoma10.0DEK, PPP2R4, RUNX1
22acute myelomonocytic leukemia10.0RUNX1, MPO, KMT2A
23megakaryocytic leukemia10.0KMT2A, MPO, RUNX1
24myelodysplastic syndromes10.0RUNX1, MPO, ANPEP, KMT2A
25myeloproliferative disorder10.0KMT2A, ANPEP, MPO, RUNX1
26acute promyelocytic leukemia10.0RUNX1, MPO, ANPEP, KMT2A
27hematologic cancer10.0RUNX1, NR3C1, KMT2A
28chronic myeloid leukemia10.0RUNX1, MPO, KMT2A
29prostate cancer10.0KMT2A, ANPEP, NR3C1, PPP2R4
30hypersensitivity reaction type ii disease10.0ANPEP, NR3C1, DEK, RUNX1
31myeloid leukemia10.0RUNX1, PPP2R4, MPO, ANPEP, KMT2A
32hepatocellular carcinoma10.0RUNX1, PPP2R4, DEK, NR3C1, ANPEP
33rheumatoid arthritis10.0RUNX1, MPO, NR3C1, TRD
34acute lymphoblastic leukemia, childhood10.0RUNX1, NR3C1, ANPEP, TRD, KMT2A
35burkitt's lymphoma10.0RUNX1, ANPEP, TRD, KMT2A
36acute lymphocytic leukemia9.9RUNX1, PPP2R4, MPO, NR3C1, ANPEP, TRD
37precursor t-cell acute lymphoblastic leukemia9.9RUNX1, MPO, NR3C1, ANPEP, TRD, NUP214
38leukemia9.9RUNX1, PPP2R4, MPO, DEK, NR3C1, ANPEP

Graphical network of the top 20 diseases related to Acute Undifferentiated Leukemia:



Diseases related to acute undifferentiated leukemia

Clinical Features for Acute Undifferentiated Leukemia

Drugs & Therapeutics for Acute Undifferentiated Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Acute Undifferentiated Leukemia

Search CenterWatch for Acute Undifferentiated Leukemia

Genetic Tests for Acute Undifferentiated Leukemia

Anatomical Context for Acute Undifferentiated Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Acute Undifferentiated Leukemia:

33
Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells

Animal Models for Acute Undifferentiated Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Acute Undifferentiated Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0RUNX1, DEK, TRD, SKI, KMT2A
2MP:00053977.8RUNX1, MPO, NR3C1, ANPEP, TRD, KMT2A
3MP:00053857.8KMT2A, SKI, TRD, ANPEP, NR3C1, MPO
4MP:00053767.5MPO, DEK, NR3C1, TRD, SKI, KMT2A

Publications for Acute Undifferentiated Leukemia

Sources:
51PubMed
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Articles related to Acute Undifferentiated Leukemia:

(show all 44)
idTitleAuthorsYear
1
Prethymic cytoplasmic CD3 negative acute lymphoblastic leukemia or acute undifferentiated leukemia: a case report. (22937302)
2011
2
Molecular characterization of alternative SET-NUP214 fusion transcripts in a case of acute undifferentiated leukemia. (20682390)
2010
3
Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiated leukemia with Set-Can translocation. (18096310)
2008
4
SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. (17569777)
2007
5
Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. (11231286)
2001
6
Activation of EVI1 transcripts with chromosomal translocation joining the TCRVbeta locus and the EVI1 gene in human acute undifferentiated leukemia cell line (Kasumi-3) with a complex translocation of der(3)t(3;7;8). (10482986)
1999
7
Acute undifferentiated leukemia with an unusual CD7+ CD56+ CD33+ immunophenotype of NK progenitors. (8656693)
1996
8
CD7, HLA-DR, CD38 positive acute undifferentiated leukemia with subcutaneous tumor and thymoma]. (8827877)
1996
9
Detection of major and minor bcr/abl fusion gene transcripts in a patient with acute undifferentiated leukemia secondary to treatment with an alkylating agent. (7596151)
1995
10
Acute leukemia coexpressing myeloid, B- and T-lineage associated markers: multiparameter analysis of criteria defining lineage commitment and maturational stage in a case of undifferentiated leukemia. (7869761)
1995
11
Immunological definition of acute minimally differentiated myeloid leukemia (MO) and acute undifferentiated leukemia (AUL). (7496349)
1995
12
Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia. (8131851)
1994
13
Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. (8294483)
1994
14
Acute undifferentiated leukemia with CD7+ and CD13+ immunophenotype. Lack of molecular lineage commitment and association with poor prognostic features. (1370211)
1992
15
Acute undifferentiated leukemia from the viewpoints of diagnosis and therapy]. (1331562)
1992
16
Acute undifferentiated leukemia (AUL): a case report and a proposed system of classification. (1376964)
1992
17
Acute undifferentiated leukemia with CD7+ and CD13+ immunophenotype. (1379512)
1992
18
The diagnosis of acute leukemia with undifferentiated or minimally differentiated blasts. (1581403)
1992
19
Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia. (1384675)
1992
20
Immunophenotyping analysis of acute undifferentiated leukemia]. (1518141)
1992
21
Acute unclassified leukemia originating from undifferentiated cells with the aberrant rearrangement and expression of immunoglobulin and T-cell receptor genes. (1827509)
1991
22
Small non-cleaved-cell lymphoma (undifferentiated lymphoma, Burkitt's type) in American adults: results with treatment designed for acute lymphoblastic leukemia. (2003515)
1991
23
Clinical usefulness of immunocytochemical detection of myeloperoxidase in undifferentiated and biphenotypic acute leukemias. (1666891)
1991
24
Heterogeneity of acute "undifferentiated" leukemia of childhood: ultrastructural, immunophenotypic, and karyotypic analyses. (2309978)
1990
25
Phenotypic, genotypic, cytochemical, and ultrastructural characterization of acute undifferentiated leukemia. (2395382)
1990
26
In-vitro differentiation of acute undifferentiated leukemia cells: surface marker and colony-formation analysis. (2818950)
1989
27
Molecular analysis of acute undifferentiated leukemia: two distinct subgroups at the DNA and RNA levels. (2790199)
1989
28
Heterogeneity in acute undifferentiated leukemia. (3198552)
1988
29
Heterogeneity of acute undifferentiated leukemia at the immunoglobulin and T-cell receptor genes level. (3104260)
1987
30
Acute undifferentiated leukemia: implications for cellular origin and clonality suggested by analysis of surface markers and immunoglobulin gene rearrangement. (3017476)
1986
31
Identification of monocytic nature in acute undifferentiated leukemia by in vitro marrow culture study. (3635419)
1986
32
Immunophenotypic transformation from acute undifferentiated leukemia to Burkitt's-like acute lymphoblastic leukemia. (3463212)
1986
33
Conversion of acute undifferentiated leukemia phenotypes: analysis of clonal development. (2948079)
1986
34
Risk groups in a multicenter pilot study for treatment of acute lymphoblastic and acute undifferentiated leukemia in adults. (3861487)
1985
35
Characterization of acute undifferentiated leukemia by combined analysis of plasma membrane-associated gamma-glutamyltranspeptidase and soluble terminal transferase. (2861868)
1985
36
Acute undifferentiated leukemia: induction of partial differentiation by phorbol ester. (3990334)
1985
37
Acute erythroblastic leukemia presenting as acute undifferentiated leukemia: a report of two cases with ultrastructural features. (3858611)
1985
38
Monoclonal antibody MCS-2 as the marker of phorbol diester-induced myeloid differentiation in acute undifferentiated leukemia. (6372996)
1984
39
Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. (6375764)
1984
40
Multicentre pilot study for therapy of acute lymphoblastic and acute undifferentiated leukemia in adults. (6345290)
1983
41
Monocytes with binding capacity to sheep red blood cells in a case of acute undifferentiated leukemia. (6837571)
1983
42
Myeloblastic and lymphoblastic markers in acute undifferentiated leukemia and chronic myelogenous leukemia in blast crisis. (6937237)
1980
43
Marked hypodiploidy in a case of acute undifferentiated leukemia. (474573)
1979
44
Terminal deoxyribonucleotidyl transferase activity in acute undifferentiated leukemia. (1275943)
1976

Genetic Variations for Acute Undifferentiated Leukemia

Expression for genes affiliated with Acute Undifferentiated Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Undifferentiated Leukemia

Search GEO for disease gene expression data for Acute Undifferentiated Leukemia.

Pathways for genes affiliated with Acute Undifferentiated Leukemia

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SET, NUP214
29.5KMT2A, MPO, RUNX1
39.4SKI, ANPEP, MPO

Compounds for genes affiliated with Acute Undifferentiated Leukemia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate4510.0ANPEP, MPO
2monochloroacetic acid4510.0MPO, ANPEP
3budesonide45 50 1111.8NR3C1, MPO
4fluticasone propionate45 50 60 1112.8NR3C1, MPO
5sodium fluoride459.6ANPEP, PPP2R4
6prednisolone45 29 1111.4KMT2A, NR3C1, MPO, RUNX1
7doxorubicin45 50 1111.2RUNX1, NR3C1, ANPEP, KMT2A
8butyrate459.2ANPEP, NR3C1, MPO, RUNX1
9etoposide45 50 60 1112.1KMT2A, NR3C1, RUNX1
10leucine459.0PPP2R4, ANPEP, SKI, KMT2A
11proline459.0RUNX1, PPP2R4, ANPEP, KMT2A
12oligonucleotide458.7RUNX1, PPP2R4, ANPEP, KMT2A
13threonine458.7SET, KMT2A, ANPEP, PPP2R4, RUNX1
14retinoic acid45 249.4RUNX1, PPP2R4, MPO, NR3C1, ANPEP, KMT2A
15serine458.1RUNX1, PPP2R4, MPO, NR3C1, ANPEP, KMT2A

GO Terms for genes affiliated with Acute Undifferentiated Leukemia

Sources:
16Gene Ontology
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Cellular components related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.8SET, SETBP1, KMT2A, SKI, NR3C1, DEK

Biological processes related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:0351629.5KMT2A, RUNX1
2gene expressionGO:0104678.9SET, SKI, NUP214, NR3C1

Molecular functions related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1repressing transcription factor bindingGO:0704919.7SKI, RUNX1
2protein phosphatase type 2A regulator activityGO:0086019.4SET, PPP2R4

Products for genes affiliated with Acute Undifferentiated Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Undifferentiated Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet