MCID: ACT140
MIFTS: 28

Acute Undifferentiated Leukemia malady

Blood diseases, Cancer diseases categories

Summaries for Acute Undifferentiated Leukemia

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32MalaCards
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MalaCards: Acute Undifferentiated Leukemia is related to acute leukemia and leukemia. An important gene associated with Acute Undifferentiated Leukemia is KMT2A (lysine (K)-specific methyltransferase 2A), and among its related pathways are Stabilization of mRNA by HuR and Transcriptional misregulation in cancer. The compounds alpha-naphthyl butyrate and monochloroacetic acid have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and hematopoietic system.

Aliases & Classifications for Acute Undifferentiated Leukemia

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48Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Aliases & Descriptions:

acute undifferentiated leukemia 48 60


External Ids:

ICD10 via Orphanet26 C95.0
UMLS via Orphanet61 C0856823

Related Diseases for Acute Undifferentiated Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Acute Undifferentiated Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.3RUNX1, PPP2R4, MPO, ANPEP, TRD, KMT2A
2leukemia31.3RUNX1, PPP2R4, MPO, DEK, NR3C1, ANPEP
3acute myeloid leukemia30.5NUP214, RUNX1
4myeloid leukemia30.5RUNX1, PPP2R4, MPO, ANPEP, KMT2A
5monocytic leukemia30.4RUNX1, KMT2A
6lymphoblastic leukemia10.5
7acute monocytic leukemia10.3
8acute t cell leukemia10.3
9t-cell leukemia10.1
10thymoma10.1
11bilineal acute leukemia10.1
12peritonitis10.0MPO
13sarcoma10.0ANPEP, RUNX1
14ovarian cancer10.0PPP2R4, RUNX1
15myeloid sarcoma10.0KMT2A, ANPEP, MPO
16lymphoblastic lymphoma10.0KMT2A, MPO
17precursor b-cell acute lymphoblastic leukemia10.0MPO, ANPEP, KMT2A
18chronic myelomonocytic leukemia10.0MPO, RUNX1
19newborn respiratory distress syndrome10.0NR3C1, MPO
20acute myeloid leukemia, adult10.0RUNX1, KMT2A
21adenocarcinoma10.0KMT2A, ANPEP, NR3C1
22retinoblastoma10.0DEK, PPP2R4, RUNX1
23acute myelomonocytic leukemia10.0RUNX1, MPO, KMT2A
24megakaryocytic leukemia10.0KMT2A, MPO, RUNX1
25myelodysplastic syndromes10.0RUNX1, MPO, ANPEP, KMT2A
26myeloproliferative disorder10.0KMT2A, ANPEP, MPO, RUNX1
27acute promyelocytic leukemia10.0RUNX1, MPO, ANPEP, KMT2A
28hematologic cancer10.0RUNX1, NR3C1, KMT2A
29chronic myeloid leukemia10.0RUNX1, MPO, KMT2A
30prostate cancer10.0KMT2A, ANPEP, NR3C1, PPP2R4
31hypersensitivity reaction type ii disease10.0ANPEP, NR3C1, DEK, RUNX1
32hepatocellular carcinoma10.0RUNX1, PPP2R4, DEK, NR3C1, ANPEP
33rheumatoid arthritis10.0RUNX1, MPO, NR3C1, TRD
34acute lymphoblastic leukemia, childhood10.0RUNX1, NR3C1, ANPEP, TRD, KMT2A
35burkitt's lymphoma10.0RUNX1, ANPEP, TRD, KMT2A
36acute lymphocytic leukemia9.9RUNX1, PPP2R4, MPO, NR3C1, ANPEP, TRD
37precursor t-cell acute lymphoblastic leukemia9.9RUNX1, MPO, NR3C1, ANPEP, TRD, NUP214

Graphical network of the top 20 diseases related to Acute Undifferentiated Leukemia:



Diseases related to acute undifferentiated leukemia

Clinical Features for Acute Undifferentiated Leukemia

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Drugs & Therapeutics for Acute Undifferentiated Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Acute Undifferentiated Leukemia

Drug clinical trials:

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Search NIH Clinical Center for Acute Undifferentiated Leukemia

Search CenterWatch for Acute Undifferentiated Leukemia

Genetic Tests for Acute Undifferentiated Leukemia

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Anatomical Context for Acute Undifferentiated Leukemia

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Animal Models for Acute Undifferentiated Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Acute Undifferentiated Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0DEK, TRD, SKI, KMT2A, RUNX1
2MP:00053977.8MPO, KMT2A, TRD, ANPEP, NR3C1, RUNX1
3MP:00053857.8KMT2A, RUNX1, MPO, NR3C1, ANPEP, TRD
4MP:00053767.5DEK, RUNX1, NR3C1, TRD, SKI, KMT2A

Publications for Acute Undifferentiated Leukemia

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Genetic Variations for Acute Undifferentiated Leukemia

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Expression for genes affiliated with Acute Undifferentiated Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Acute Undifferentiated Leukemia

Search GEO for disease gene expression data for Acute Undifferentiated Leukemia.

Pathways for genes affiliated with Acute Undifferentiated Leukemia

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6SET, NUP214
29.5KMT2A, MPO, RUNX1
39.4SKI, ANPEP, MPO

Compounds for genes affiliated with Acute Undifferentiated Leukemia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1alpha-naphthyl butyrate4410.0MPO, ANPEP
2monochloroacetic acid4410.0ANPEP, MPO
3budesonide44 49 1111.8MPO, NR3C1
4fluticasone propionate44 49 59 1112.8MPO, NR3C1
5sodium fluoride449.6ANPEP, PPP2R4
6prednisolone44 28 1111.4KMT2A, NR3C1, MPO, RUNX1
7doxorubicin44 49 1111.2ANPEP, NR3C1, RUNX1, KMT2A
8butyrate449.2ANPEP, NR3C1, MPO, RUNX1
9etoposide44 49 59 1112.1NR3C1, KMT2A, RUNX1
10leucine449.0PPP2R4, SKI, KMT2A, ANPEP
11proline449.0PPP2R4, ANPEP, RUNX1, KMT2A
12oligonucleotide448.7RUNX1, PPP2R4, ANPEP, KMT2A
13threonine448.7ANPEP, RUNX1, PPP2R4, SET, KMT2A
14retinoic acid44 249.4MPO, ANPEP, KMT2A, RUNX1, PPP2R4, NR3C1
15serine448.1ANPEP, NR3C1, MPO, PPP2R4, RUNX1, KMT2A

GO Terms for genes affiliated with Acute Undifferentiated Leukemia

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16Gene Ontology
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Cellular components related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.8SET, SETBP1, KMT2A, SKI, NR3C1, DEK

Biological processes related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:0351629.5KMT2A, RUNX1
2gene expressionGO:0104678.9SET, SKI, NUP214, NR3C1

Molecular functions related to Acute Undifferentiated Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1repressing transcription factor bindingGO:0704919.7SKI, RUNX1
2protein phosphatase type 2A regulator activityGO:0086019.4SET, PPP2R4

Products for genes affiliated with Acute Undifferentiated Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Acute Undifferentiated Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet