MCID: ACT043
MIFTS: 31

Acute Urate Nephropathy malady

Category: Nephrological diseases

Aliases & Classifications for Acute Urate Nephropathy

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Aliases & Descriptions for Acute Urate Nephropathy:

Name: Acute Urate Nephropathy 10 12 65
Nephrolithiasis, Uric Acid, Susceptibility to 11 24
Uric Acid Nephrolithiasis 10 47
 
Uric Acid Urolithiasis 10 65
Uric Acid Renal Calculus 65

Classifications:



External Ids:

Disease Ontology10 DOID:580
ICD9CM29 274.11
UMLS65 C0403719, C0341712, C0558595

Summaries for Acute Urate Nephropathy

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MalaCards based summary: Acute Urate Nephropathy, also known as nephrolithiasis, uric acid, susceptibility to, is related to nephrolithiasis, uric acid and diarrhea 4, malabsorptive, congenital. An important gene associated with Acute Urate Nephropathy is ZNF365 (Zinc Finger Protein 365), and among its related pathways are Proximal tubule bicarbonate reclamation and Uricosurics Pathway, Pharmacodynamics. Affiliated tissues include kidney and heart, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Related Diseases for Acute Urate Nephropathy

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Diseases related to Acute Urate Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1nephrolithiasis, uric acid12.0
2diarrhea 4, malabsorptive, congenital10.5HPRT1, ZNF365
3spinocerebellar ataxia 1810.4SLC26A6, SLC9A3
4pneumonia caused by pseudomonas aeruginosa infection10.4SLC26A6, SLC9A3
5spastic paraplegia, optic atrophy, and neuropathy10.3HPRT1, SLC22A12, SLC2A9
6medullary cystic kidney disease 210.3HPRT1, SLC22A12, SLC2A9
7warburg micro syndrome10.3HPRT1, SLC22A12, SLC2A9
8klinefelter's syndrome10.3HPRT1, SLC22A12, SLC2A9
9brain cancer10.3HPRT1, SLC22A12, SLC2A9
10retinal ischemia10.2ATP6V0A4, SLC26A6, SLC9A3
11alzheimer disease10.1
12end stage renal failure10.1
13osteoarthritis10.1
14temporal lobe epilepsy10.1
15common cold10.1
16osteomalacia10.1
17pasteurellosis10.1
18hereditary spherocytosis10.1
19transient global amnesia10.1
20balanitis10.1
21prostatitis10.1
22intestinal disease10.1
23amyloidosis10.1
24spinal cord infarction10.1
25persistence of mullerian derivatives with lymphangiectasia and postaxial polydactyly10.1AGXT, TRIM37
26breast cancer10.1
27sudden infant death syndrome10.1
28hepatitis10.1
29hepatitis c10.1
30neuromyelitis optica10.1AGXT, SLC22A12, SLC2A9, ZNF365
31tyrosinemia10.1GGT1, TRIM37
32leukodystrophy10.0AGXT, ATP6V0A4
33folic acid deficiency anemia10.0GGT1, GGT2
34diabetic encephalopathy10.0GGT1, GGT2
35fetal hemoglobin quantitative trait locus 310.0HPRT1, MGAM
36polyneuropathy in collagen vascular disease10.0GGT1, GGT2
37transient tic disorder10.0GGT1, GGT2
38bile duct cystadenocarcinoma10.0GGT1, GGT2
39small intestine leiomyoma10.0GGT1, GGT2
40motility-related diarrhea10.0MGAM, SLC9A3
41transient cerebral ischemia10.0GGT1, GGT2
42osteoclast-like giant cell neoplasm of the pancreas9.9GGT1, GGT2
43y-linked disease9.9AGXT, ATP6V0A4, GGT1
44benign familial infantile epilepsy9.9GGT1, TRIM37
45gastrointestinal defects and immunodeficiency syndrome9.9GGT1, MGAM
46biliary dyskinesia9.8GGT1, GGT2
47plasmodium ovale malaria9.6HAVCR1, MGAM
48discrete subaortic stenosis6.7AGXT, ATP6V0A4, CLNK, GGT1, GGT2, HAVCR1

Graphical network of the top 20 diseases related to Acute Urate Nephropathy:



Diseases related to acute urate nephropathy

Symptoms for Acute Urate Nephropathy

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Drugs & Therapeutics for Acute Urate Nephropathy

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Drugs for Acute Urate Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Vasodilator AgentsPhase 32926
2Pharmaceutical SolutionsPhase 37004
3diureticsPhase 31194
4
Rasburicaseapproved, investigationalPhase 225134774-45-1
Synonyms:
Elitek
Fasturtec
 
Urate oxidase
Uricase
rasburicase
5
Uric Acidexperimental, investigationalPhase 212069-93-21175
Synonyms:
1H-Purine-2,6,8-triol
2,6,8-Trihydroxypurine
2,6,8-Trioxopurine
2,6,8-Trioxypurine
 
7,9-dihydro-1H-purine-2,6,8(3H)-trione
Lithate
Lithic acid
Purine-2,6,8(1H,3H,9H)-trione
Urate
Uric acid
6Antirheumatic AgentsPhase 28496
7
Mycophenolate mofetilapproved, investigational898128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate Mofetil
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
8
Mycophenolic acidapproved89824280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
Melbex
 
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolic Acid
Mycophenolsaeure
Myfortic
9Immunosuppressive Agents10422
10Anti-Bacterial Agents9140
11Antibiotics, Antitubercular5971
12Calcineurin Inhibitors1223
13Immunologic Factors18483

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)CompletedNCT00608491Phase 3
2Lowering Serum Uric Acid to Prevent Acute Kidney InjuryCompletedNCT00756964Phase 2
3Predicting Acute Kidney Injury After Coronary Artery Bypass GraftRecruitingNCT02081261
4MMF and Calcineurin Inhibitor Withdrawal in CANTerminatedNCT00204230

Search NIH Clinical Center for Acute Urate Nephropathy

Genetic Tests for Acute Urate Nephropathy

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Anatomical Context for Acute Urate Nephropathy

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MalaCards organs/tissues related to Acute Urate Nephropathy:

33
Kidney, Heart

Animal Models for Acute Urate Nephropathy or affiliated genes

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MGI Mouse Phenotypes related to Acute Urate Nephropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.3AGXT, ATP6V0A4, GGT1, HPRT1, RHCG, SLC22A12
2MP:00053766.8AGXT, ATP6V0A4, GGT1, HPRT1, MGAM, RHCG

Publications for Acute Urate Nephropathy

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Articles related to Acute Urate Nephropathy:

idTitleAuthorsYear
1
Osteoporosis and cancer. (23877475)
2013
2
Methylated spirit burns: an ongoing problem. (22583476)
2012
3
Posterior knee dislocation following septic arthritis of the knee. (23569696)
2012
4
Inhibitor of apoptosis proteins as novel targets in inflammatory processes. (21817100)
2011
5
Pelvic inflammatory disease caused by citrobacter. (16183602)
2005
6
Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma. (10428394)
1999

Variations for Acute Urate Nephropathy

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Expression for genes affiliated with Acute Urate Nephropathy

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Search GEO for disease gene expression data for Acute Urate Nephropathy.

Pathways for genes affiliated with Acute Urate Nephropathy

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GO Terms for genes affiliated with Acute Urate Nephropathy

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Cellular components related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:003198810.4SLC26A6, SLC9A3
2plasma membraneGO:00058868.5GGT1, GGT2, SLC22A12, SLC26A6, SLC2A9

Biological processes related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1anion transmembrane transportGO:009865610.3SLC22A12, SLC26A6
2regulation of pHGO:000688510.2ATP6V0A4, RHCG
3urate metabolic processGO:004641510.0LRRC16A, SLC2A9
4glutathione derivative biosynthetic processGO:19016879.9GGT1, GGT2
5leukotriene biosynthetic processGO:00193709.5GGT1, GGT2
6zymogen activationGO:00316389.3GGT1, GGT2
7transmembrane transportGO:00550859.0ATP6V0A4, RHCG, SLC26A6, SLC9A3

Sources for Acute Urate Nephropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet