MCID: ACT043
MIFTS: 33

Acute Urate Nephropathy malady

Category: Nephrological diseases

Aliases & Classifications for Acute Urate Nephropathy

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Aliases & Descriptions for Acute Urate Nephropathy:

Name: Acute Urate Nephropathy 11 13 66
Uric Acid Urolithiasis 11 66
 
Uric Acid Nephrolithiasis 11
Uric Acid Renal Calculus 66

Classifications:



External Ids:

Disease Ontology11 DOID:580
ICD9CM30 274.11

Summaries for Acute Urate Nephropathy

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MalaCards based summary: Acute Urate Nephropathy, also known as uric acid urolithiasis, is related to nephrolithiasis, uric acid and diarrhea 4, malabsorptive, congenital. An important gene associated with Acute Urate Nephropathy is ZNF365 (Zinc Finger Protein 365), and among its related pathways are Uricosurics Pathway, Pharmacodynamics and Proximal tubule bicarbonate reclamation. Affiliated tissues include kidney and heart, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Related Diseases for Acute Urate Nephropathy

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Diseases related to Acute Urate Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1nephrolithiasis, uric acid11.9
2diarrhea 4, malabsorptive, congenital10.7HPRT1, ZNF365
3nephrolithiasis10.7
4cocaine intoxication10.6SLC26A6, SLC9A3
5spastic paraplegia, optic atrophy, and neuropathy10.5HPRT1, SLC22A12, SLC2A9
6glomerulocystic kidney disease with hyperuricemia and isosthenuria10.5HPRT1, SLC22A12, SLC2A9
7retinal vein occlusion10.5ATP6V0A4, SLC26A6, SLC9A3
8van maldergem syndrome10.5HPRT1, SLC22A12, SLC2A9
9nontoxic goiter10.4HPRT1, SLC22A12, SLC2A9
10spinocerebellar ataxia 1810.4SLC26A6, SLC9A3, XK
11monocular esotropia10.4ATP6V0A4, XK
12motility-related diarrhea10.3SLC9A3, XK
13mild pre-eclampsia10.3ADCY10, AGXT, ATP6V0A4
14tuberous sclerosis-110.2ADCY10, ATP6V0A4, XK
15mental retardation, x-linked 7310.1HPRT1, MGAM
16inflammatory diarrhea10.1MGAM, SLC9A3, XK
17sex differentiation disease10.1HPRT1, INS, SLC22A12, SLC2A9
18hypokalemic periodic paralysis, type 110.1ATP6V0A4, INS, XK
19chronic progressive external ophthalmoplegia10.1HAVCR1, XK
20astrakhan spotted fever10.0ATP6V0A4, MGAM, XK
21cystinuria9.9
22renal tubular acidosis9.9
23hyperuricemia9.9
24acute diarrhea9.9
25diarrhea9.9
26hypodermyiasis9.9HAVCR1, MGAM, XK
27mononeuritis9.8ATP6V0A4, HAVCR1, INS, XK
28glucosidase acid-1,4-alpha deficiency9.8ADCY10, INS
29autosomal genetic disease9.7AGXT, ATP6V0A4, GGT1
30lacrimal duct cancer9.7GGT1, GGT2
31malignant parietal pleura tumor9.7GGT1, GGT2
32glomerulosclerosis9.7GGT1, GGT2
33duodenal disease9.7GGT1, GGT2
34eversion of lacrimal punctum9.7GGT1, GGT2
35tic disorder9.6GGT1, GGT2
36acanthoma9.6GGT1, GGT2
37tricuspid valve stenosis9.5GGT1, GGT2
38neutropenia9.5ADCY10, AGXT, ATP6V0A4, SLC22A12, SLC26A6, SLC2A9
39epilepsy with generalized tonic-clonic seizures9.3GGT1, GGT2
40perianal skin paget's disease9.0GGT1, GGT2, INS, XK
41subvalvular aortic stenosis4.4ADCY10, AGXT, ATP6V0A4, CARMIL1, CLNK, GGT1

Graphical network of the top 20 diseases related to Acute Urate Nephropathy:



Diseases related to acute urate nephropathy

Symptoms for Acute Urate Nephropathy

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Drugs & Therapeutics for Acute Urate Nephropathy

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Drugs for Acute Urate Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1diureticsPhase 31338
2
Uric acidPhase 212769-93-21175
Synonyms:
1H-Purine-2,6,8-triol
2,6,8-Trihydroxypurine
2,6,8-Trioxopurine
2,6,8-Trioxypurine
 
7,9-dihydro-1H-purine-2,6,8(3H)-trione
Lithate
Lithic acid
Purine-2,6,8(1H,3H,9H)-trione
Urate
Uric acid
3
rasburicasePhase 225134774-45-1
Synonyms:
Elitek
Fasturtec
 
Urate oxidase
Uricase
rasburicase
4
Mycophenolic acid91924280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
5
Mycophenolate mofetil919128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)CompletedNCT00608491Phase 3
2Lowering Serum Uric Acid to Prevent Acute Kidney InjuryCompletedNCT00756964Phase 2
3Predicting Acute Kidney Injury After Coronary Artery Bypass GraftCompletedNCT02081261
4MMF and Calcineurin Inhibitor Withdrawal in CANTerminatedNCT00204230

Search NIH Clinical Center for Acute Urate Nephropathy

Genetic Tests for Acute Urate Nephropathy

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Anatomical Context for Acute Urate Nephropathy

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MalaCards organs/tissues related to Acute Urate Nephropathy:

34
Kidney, Heart

Animal Models for Acute Urate Nephropathy or affiliated genes

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MGI Mouse Phenotypes related to Acute Urate Nephropathy:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053676.7AGXT, ATP6V0A4, GGT1, HPRT1, HUWE1, INS
2MP:00053765.8ADCY10, AGXT, ATP6V0A4, GGT1, HPRT1, HUWE1

Publications for Acute Urate Nephropathy

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Articles related to Acute Urate Nephropathy:

idTitleAuthorsYear
1
Seizure-induced acute urate nephropathy: case report and review. (23918111)
2013
2
Acute urate nephropathy precipitated by acute diarrhea. (19736489)
2009
3
Acute urate nephropathy due to partial hypoxanthine-guanine phosphoribosyl transferase deficiency. (2115630)
1990
4
Acute urate nephropathy induced by Ticrynafen and exacerbated by urographic contrast medium. (7281384)
1981
5
Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy. (16037)
1977
6
A micropuncture study of the early phase of acute urate nephropathy. (956394)
1976

Variations for Acute Urate Nephropathy

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Expression for genes affiliated with Acute Urate Nephropathy

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Search GEO for disease gene expression data for Acute Urate Nephropathy.

Pathways for genes affiliated with Acute Urate Nephropathy

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GO Terms for genes affiliated with Acute Urate Nephropathy

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Cellular components related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:003198810.7SLC26A6, SLC9A3
2anchored component of external side of plasma membraneGO:00313629.7GGT1, GGT2
3brush border membraneGO:00315269.6ATP6V0A4, SLC22A12, SLC26A6, SLC9A3
4apical plasma membraneGO:00163248.7ATP6V0A4, MGAM, RHCG, SLC22A12, SLC26A6, SLC2A9
5extracellular exosomeGO:00700626.5ATP6V0A4, CARMIL1, GGT1, GGT2, HPRT1, HUWE1
6plasma membraneGO:00058865.6ADCY10, ATP6V0A4, CARMIL1, GGT1, GGT2, MGAM

Biological processes related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1organic acid transmembrane transportGO:190382510.3SLC22A12, SLC2A9
2oxalic acid secretionGO:004672410.3AGXT, SLC26A6
3urate metabolic processGO:00464159.6CARMIL1, SLC22A12, SLC2A9
4regulation of pHGO:00068859.5ATP6V0A4, RHCG, SLC9A3
5leukotriene biosynthetic processGO:00193709.3GGT1, GGT2
6zymogen activationGO:00316389.0GGT1, GGT2
7glutathione biosynthetic processGO:00067508.9GGT1, GGT2

Molecular functions related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inorganic anion exchanger activityGO:000545210.4SLC22A12, SLC26A6
2urate transmembrane transporter activityGO:001514310.4SLC22A12, SLC2A9
3PDZ domain bindingGO:00301659.9SLC22A12, SLC26A6, SLC9A3
4glutathione hydrolase activityGO:00363749.6GGT1, GGT2
5gamma-glutamyltransferase activityGO:00038409.6GGT1, GGT2

Sources for Acute Urate Nephropathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet