MCID: ACT043
MIFTS: 30

Acute Urate Nephropathy malady

Nephrological diseases category

Aliases & Classifications for Acute Urate Nephropathy

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Aliases & Descriptions for Acute Urate Nephropathy:

Name: Acute Urate Nephropathy 10 12 65
Uric Acid Nephrolithiasis 10 47
Uric Acid Urolithiasis 10 65
 
Uric Acid Nephropathy 10 47
Nephrolithiasis, Uric Acid, Susceptibility to 11


Classifications:



External Ids:

Disease Ontology10 DOID:580
ICD9CM29 274.11

Summaries for Acute Urate Nephropathy

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MalaCards based summary: Acute Urate Nephropathy, also known as uric acid nephrolithiasis, is related to nephrolithiasis, uric acid and hypouricemia, renal. An important gene associated with Acute Urate Nephropathy is HPRT1 (Hypoxanthine Phosphoribosyltransferase 1), and among its related pathways are Uricosurics Pathway, Pharmacodynamics and Proximal tubule bicarbonate reclamation. Affiliated tissues include kidney, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Related Diseases for Acute Urate Nephropathy

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Diseases related to Acute Urate Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
idRelated DiseaseScoreTop Affiliating Genes
1nephrolithiasis, uric acid31.2HPRT1, ZNF365
2hypouricemia, renal30.7HPRT1, SLC22A12, SLC2A9
3nephrolithiasis11.0
4hyperammonemia due to carbonic anhydrase va deficiency10.3HPRT1, XDH
5purpura10.3HPRT1, XDH
6funisitis10.3HPRT1, NKX2-1
7acute diarrhea10.2
8diarrhea10.2
9cystinuria10.2
10phosphoribosylpyrophosphate synthetase superactivity10.2
11renal tubular acidosis10.2
12hyperuricemia10.2
13medullary cystic kidney disease 210.2HPRT1, SLC22A12, SLC2A9
14hprt-related gout10.2
15diarrhea 1, secretory chloride, congenital10.2SLC26A6, SLC9A3
16pneumonia caused by pseudomonas aeruginosa infection10.2SLC26A6, SLC9A3
17branchiootic syndrome10.1HPRT1, SLC22A12, SLC2A9, XDH
18lymphogranuloma venereum10.1HPRT1, SLC22A12, SLC2A9, XDH
19persistence of mullerian derivatives with lymphangiectasia and postaxial polydactyly10.1AGXT, TRIM37
20neuromyelitis optica10.1AGXT, SLC22A12, SLC2A9, ZNF365
21folic acid deficiency anemia10.0GGT1, GGT2
22mediastinum leiomyoma10.0GGT1, GGT2
23fetal hemoglobin quantitative trait locus 310.0HPRT1, MGAM
24corneal ectasia10.0GGT1, GGT2
25ethmoid sinusitis10.0GGT1, GGT2
26epidermolysis bullosa10.0MGAM, NKX2-1
27pancreatic cystadenoma10.0GGT1, GGT2
28sensory peripheral neuropathy10.0HPRT1, LRRC16A, SLC22A12, SLC2A9, XDH
29gastrointestinal defects and immunodeficiency syndrome9.9GGT1, MGAM
30deep corneal vascularisation9.9GGT1, GGT2
31idiopathic scoliosis9.9GGT1, GGT2
32histiocytic and dendritic cell cancer9.9GGT1, TRIM37
33motility-related diarrhea9.8MGAM, SLC9A3
34sarcomatoid transitional cell carcinoma7.7AGXT, ATP6V0A4, CLNK, DDX4, GGT1, GGT2

Graphical network of the top 20 diseases related to Acute Urate Nephropathy:



Diseases related to acute urate nephropathy

Symptoms for Acute Urate Nephropathy

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Drugs & Therapeutics for Acute Urate Nephropathy

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Drugs for Acute Urate Nephropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Rasburicaseapproved, investigationalPhase 225134774-45-1
Synonyms:
Elitek
Fasturtec
 
Urate oxidase
Uricase
rasburicase
2
Uric Acidexperimental, investigationalPhase 211269-93-21175
Synonyms:
1H-Purine-2,6,8-triol
2,6,8-Trihydroxypurine
2,6,8-Trioxopurine
2,6,8-Trioxypurine
 
7,9-dihydro-1H-purine-2,6,8(3H)-trione
Lithate
Lithic acid
Purine-2,6,8(1H,3H,9H)-trione
Urate
Uric acid
3
Mycophenolic acidapproved86424280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
Melbex
 
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolic Acid
Mycophenolsaeure
Myfortic
4
Mycophenolate mofetilapproved, investigational864128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate Mofetil
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)CompletedNCT00608491Phase 3
2Lowering Serum Uric Acid to Prevent Acute Kidney InjuryCompletedNCT00756964Phase 2
3Predicting Acute Kidney Injury After Coronary Artery Bypass GraftRecruitingNCT02081261
4MMF and Calcineurin Inhibitor Withdrawal in CANTerminatedNCT00204230

Search NIH Clinical Center for Acute Urate Nephropathy

Genetic Tests for Acute Urate Nephropathy

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Anatomical Context for Acute Urate Nephropathy

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MalaCards organs/tissues related to Acute Urate Nephropathy:

33
Kidney

Animal Models for Acute Urate Nephropathy or affiliated genes

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MGI Mouse Phenotypes related to Acute Urate Nephropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.0AGXT, ATP6V0A4, HPRT1, RHCG, SLC22A12, SLC26A6
2MP:00053797.9DDX4, GGT1, HPRT1, NKX2-1, SLC22A12, SLC26A6
3MP:00053766.1AGXT, ATP6V0A4, GGT1, HPRT1, MGAM, NKX2-1

Publications for Acute Urate Nephropathy

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Articles related to Acute Urate Nephropathy:

idTitleAuthorsYear
1
Seizure-induced acute urate nephropathy: case report and review. (23918111)
2013
2
Acute urate nephropathy precipitated by acute diarrhea. (19736489)
2009
3
Acute urate nephropathy due to partial hypoxanthine-guanine phosphoribosyl transferase deficiency. (2115630)
1990
4
Acute urate nephropathy induced by Ticrynafen and exacerbated by urographic contrast medium. (7281384)
1981
5
Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy. (16037)
1977
6
A micropuncture study of the early phase of acute urate nephropathy. (956394)
1976

Variations for Acute Urate Nephropathy

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Expression for genes affiliated with Acute Urate Nephropathy

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Search GEO for disease gene expression data for Acute Urate Nephropathy.

Pathways for genes affiliated with Acute Urate Nephropathy

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Pathways related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0SLC22A12, SLC2A9
29.7PCK2, SLC9A3
39.3GGT1, GGT2
49.3GGT1, GGT2
5
Show member pathways
9.1GGT1, GGT2, XDH

GO Terms for genes affiliated with Acute Urate Nephropathy

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Cellular components related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:003198810.3SLC26A6, SLC9A3
2peroxisomeGO:00057779.9AGXT, TRIM37, XDH
3anchored component of external side of plasma membraneGO:00313629.9GGT1, GGT2
4brush border membraneGO:00315269.6ATP6V0A4, SLC22A12, SLC26A6, SLC9A3
5apical plasma membraneGO:00163247.9ATP6V0A4, MGAM, RHCG, SLC22A12, SLC26A6, SLC2A9
6extracellular exosomeGO:00700626.3ATP6V0A4, GGT1, GGT2, HPRT1, LRRC16A, MGAM

Biological processes related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cerebral cortex neuron differentiationGO:002189510.8HPRT1, NKX2-1
2oxalic acid secretionGO:004672410.7AGXT, SLC26A6
3urate metabolic processGO:004641510.2LRRC16A, SLC22A12, SLC2A9
4zymogen activationGO:003163810.0GGT1, GGT2
5glutathione biosynthetic processGO:000675010.0GGT1, GGT2
6glutathione derivative biosynthetic processGO:190168710.0GGT1, GGT2
7regulation of pHGO:00068859.9ATP6V0A4, RHCG, SLC9A3
8leukotriene biosynthetic processGO:00193709.8GGT1, GGT2
9transmembrane transportGO:00550859.0ATP6V0A4, RHCG, SLC22A12, SLC26A6, SLC2A9, SLC9A3
10small molecule metabolic processGO:00442817.5AGXT, GGT1, GGT2, HPRT1, MGAM, PCK2

Molecular functions related to Acute Urate Nephropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione hydrolase activityGO:00363749.7GGT1, GGT2
2gamma-glutamyltransferase activityGO:00038409.6GGT1, GGT2
3PDZ domain bindingGO:00301659.5SLC22A12, SLC26A6, SLC9A3

Sources for Acute Urate Nephropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet