MCID: ACT060
MIFTS: 35

Acute Vascular Insufficiency of Intestine

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Acute Vascular Insufficiency of Intestine

MalaCards integrated aliases for Acute Vascular Insufficiency of Intestine:

Name: Acute Vascular Insufficiency of Intestine 12 14 69
Acute Gastrointestinal Tract Vascular Insuffic. 12
Acute Intestinal Vascular Insufficiency 12
Acute Git Vascular Insuffic. 12
Acute Intestinal Ischemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8590
ICD9CM 35 557.0
NCIt 47 C34356
UMLS 69 C0001363

Summaries for Acute Vascular Insufficiency of Intestine

MalaCards based summary : Acute Vascular Insufficiency of Intestine, also known as acute gastrointestinal tract vascular insuffic., is related to smarca4-deficient sarcoma of thorax and aortic arch interruption. An important gene associated with Acute Vascular Insufficiency of Intestine is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Acute Vascular Insufficiency of Intestine

Diseases related to Acute Vascular Insufficiency of Intestine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
id Related Disease Score Top Affiliating Genes
1 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
2 aortic arch interruption 10.6 IL6 TNF
3 cutaneous leishmaniasis 10.6 IL6 TNF
4 spirillary rat-bite fever 10.5 IL6 TNF
5 oculomotor nerve paralysis 10.5 IL1B IL6
6 common peroneal nerve lesion 10.5 IL1B IL6
7 toxoplasmosis 10.5 IL6 TNF
8 dyslexia 5 10.5 IL6 TNF
9 epstein-barr virus hepatitis 10.5 IL6 TNF
10 anencephaly and spina bifida x-linked 10.5 IL6 TNF
11 antigen-peptide-transporter 2 deficiency 10.5 IL6 TNF
12 tabatznik syndrome 10.4 IL1B TNF
13 gastroduodenal crohn's disease 10.4 FABP2 IL6 TNF
14 papilledema 10.4 IL6 TNF
15 sternal cleft 10.4 IL1B TNF
16 x-linked dominant intellectual disability-epilepsy syndrome 10.4 IL1B IL6
17 ethmoid sinus adenocarcinoma 10.4 IL6 TNF
18 pulmonary hypertension 10.4 IL1B TNF
19 infancy electroclinical syndrome 10.4 IL1B IL6
20 cervical squamous cell carcinoma 10.4 IL1B SOD1
21 cicatricial lagophthalmos 10.4 IL6 MAPK1 TNF
22 walker dyson syndrome 10.4 IL1B TNF
23 cataract 10.3 IL1B TNF
24 potato nose 10.3 IL6 TNF
25 spinal stenosis 10.3 GDNF IL6 TNF
26 congenital nonspherocytic hemolytic anemia 10.3 IL1B IL6
27 scrotal carcinoma 10.2 IL1B IL6 TNF
28 bipolar i disorder 10.2 IL1B IL6 TNF
29 tinea favosa 10.2 IL1B IL6 TNF
30 central nervous system leiomyosarcoma 10.2 IL1B IL6 TNF
31 indolent myeloma 10.2 IL1B IL6 TNF
32 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.2 IL1B IL6 TNF
33 acquired thrombocytopenia 10.2 IL1B IL6 TNF
34 calciphylaxis 10.2 IL1B IL6 SOD1
35 ampulla of vater neoplasm 10.2 IL1B IL6 TNF
36 benign neonatal seizures 10.2 IL1B IL6 TNF
37 keloids 10.2 IL1B IL6 TNF
38 brucella canis brucellosis 10.2 IL1B IL6 TNF
39 foodborne botulism 10.2 IL1B IL6 TNF
40 ovarian mucinous adenofibroma 10.2 IL1B IL6 TNF
41 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.2 IL1B TNF
42 noma 10.2 IL1B IL6 TNF
43 human monocytic ehrlichiosis 10.2 IL1B IL6 TNF
44 high pressure neurological syndrome 10.2 IL1B IL6 TNF
45 ostertagiasis 10.2 IL1B IL6 TNF
46 osmotic diarrhea 10.2 IL1B IL6 TNF
47 mikulicz disease 10.2 IL1B IL6 TNF
48 palmoplantar keratosis 10.2 IL1B IL6 TNF
49 breast disease 10.2 IL1B IL6 TNF
50 vacterl association 10.2 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Acute Vascular Insufficiency of Intestine:



Diseases related to Acute Vascular Insufficiency of Intestine

Symptoms & Phenotypes for Acute Vascular Insufficiency of Intestine

MGI Mouse Phenotypes related to Acute Vascular Insufficiency of Intestine:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 CEP290 GDNF IL1B IL6 MAPK1 SOD1
2 growth/size/body region MP:0005378 10.02 TNF CEP290 FABP2 GDNF IL6 MAPK1
3 endocrine/exocrine gland MP:0005379 9.95 GDNF HSPA4 IL6 MAPK1 OCLN SOD1
4 nervous system MP:0003631 9.85 CEP290 GDNF HSPA4 IL1B IL6 MAPK1
5 liver/biliary system MP:0005370 9.8 CEP290 FABP2 IL6 MAPK1 SOD1 TNF
6 muscle MP:0005369 9.73 IL6 MAPK1 OCLN SOD1 TNF GDNF
7 reproductive system MP:0005389 9.56 HSPA4 IL6 MAPK1 OCLN SOD1 TNF
8 skeleton MP:0005390 9.17 CEP290 IL1B IL6 MAPK1 OCLN SOD1

Drugs & Therapeutics for Acute Vascular Insufficiency of Intestine

Drugs for Acute Vascular Insufficiency of Intestine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4 9005-49-6
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3 Anticoagulants Phase 4
4 calcium heparin Phase 4
5 Calcium, Dietary Phase 4
6 Fibrinolytic Agents Phase 4
7 Heparin, Low-Molecular-Weight Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia Completed NCT02645240 Phase 4 Heparin injection
2 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
3 Plasma i-FABP as Predictor for Irreversible Bowel Ischemia Unknown status NCT01788904
4 Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair Completed NCT01915446
5 Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study Recruiting NCT02772913

Search NIH Clinical Center for Acute Vascular Insufficiency of Intestine

Genetic Tests for Acute Vascular Insufficiency of Intestine

Anatomical Context for Acute Vascular Insufficiency of Intestine

MalaCards organs/tissues related to Acute Vascular Insufficiency of Intestine:

39
Kidney

Publications for Acute Vascular Insufficiency of Intestine

Variations for Acute Vascular Insufficiency of Intestine

Expression for Acute Vascular Insufficiency of Intestine

Search GEO for disease gene expression data for Acute Vascular Insufficiency of Intestine.

Pathways for Acute Vascular Insufficiency of Intestine

Pathways related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 40)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 GDNF HSPA4 IL1B IL6 TNF
2
Show member pathways
12.49 IL1B IL6 MAPK1 TNF
3
Show member pathways
12.48 IL1B IL6 MAPK1 TNF
4
Show member pathways
12.33 IL1B IL6 MAPK1 TNF
5
Show member pathways
12.22 IL1B IL6 MAPK1 TNF
6
Show member pathways
12.13 IL1B IL6 MAPK1 TNF
7 12.11 IL1B IL6 MAPK1 TNF
8
Show member pathways
12.05 IL1B IL6 TNF
9 11.97 MAPK1 OCLN TNF
10 11.95 IL1B MAPK1 TNF
11 11.89 IL1B IL6 TNF
12 11.85 IL1B IL6 MAPK1
13
Show member pathways
11.85 IL1B IL6 TNF
14 11.8 IL1B IL6 TNF
15 11.79 IL1B IL6 TNF
16 11.77 IL1B IL6 MAPK1 TNF
17 11.75 IL1B IL6 TNF
18 11.67 IL1B IL6 TNF
19 11.66 IL1B IL6 MAPK1 TNF
20 11.58 IL1B IL6 TNF
21 11.56 IL1B IL6 MAPK1 TJP1
22 11.5 IL1B IL6 TNF
23 11.44 IL1B IL6 TNF
24 11.44 IL1B IL6 MAPK1 TNF
25 11.43 IL1B IL6 TNF
26 11.43 GDNF IL1B IL6 MAPK1 TNF
27 11.38 IL1B IL6 TNF
28
Show member pathways
11.26 IL1B IL6 MAPK1 TNF
29 11.24 IL1B IL6 TNF
30 11.23 IL1B IL6 TNF
31 11.18 IL1B IL6 TNF
32 11.14 IL1B IL6 TNF
33 11.11 IL1B IL6 TNF
34 11.06 MAPK1 TNF
35 11.02 IL6 TNF
36 10.95 IL6 TNF
37 10.92 IL1B MAPK1 TNF
38 10.87 IL1B TNF
39 10.81 IL1B IL6
40 10.47 IL1B IL6 MAPK1 SOD1

GO Terms for Acute Vascular Insufficiency of Intestine

Cellular components related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendrite cytoplasm GO:0032839 9.16 MAPK1 SOD1
2 apicolateral plasma membrane GO:0016327 8.96 OCLN TJP1
3 protein complex GO:0043234 8.92 CEP290 GOT2 MAPK1 SOD1

Biological processes related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 CEP290 IL1B IL6 MAPK1 TNF
2 positive regulation of gene expression GO:0010628 9.92 IL1B IL6 MAPK1 TNF
3 MAPK cascade GO:0000165 9.83 GDNF IL1B MAPK1 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B IL6 TNF
5 response to ethanol GO:0045471 9.77 GOT2 SOD1 TJP1
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.77 IL1B IL6 TNF
7 response to lipopolysaccharide GO:0032496 9.73 IL1B IL6 MAPK1 TJP1
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.64 IL1B TNF
9 muscle cell cellular homeostasis GO:0046716 9.63 IL6 SOD1
10 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
11 positive regulation of chemokine production GO:0032722 9.61 IL6 TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
15 positive regulation of interleukin-6 production GO:0032755 9.58 IL1B IL6 TNF
16 positive regulation of protein import into nucleus, translocation GO:0033160 9.57 IL6 MAPK1
17 positive regulation of chemokine biosynthetic process GO:0045080 9.56 IL1B TNF
18 myeloid cell homeostasis GO:0002262 9.55 IL6 SOD1
19 negative regulation of lipid storage GO:0010888 9.51 IL6 TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 IL1B IL6 TNF
21 regulation of establishment of endothelial barrier GO:1903140 9.49 IL1B TNF
22 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.48 IL6 TNF
23 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
24 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
25 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.33 GDNF IL1B TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 IL1B MAPK1 TNF
28 activation of MAPK activity GO:0000187 8.92 IL1B MAPK1 SOD1 TNF

Sources for Acute Vascular Insufficiency of Intestine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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