MCID: ACT060
MIFTS: 37

Acute Vascular Insufficiency of Intestine

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Acute Vascular Insufficiency of Intestine

MalaCards integrated aliases for Acute Vascular Insufficiency of Intestine:

Name: Acute Vascular Insufficiency of Intestine 12 14 69
Acute Gastrointestinal Tract Vascular Insuffic. 12
Acute Intestinal Vascular Insufficiency 12
Acute Git Vascular Insuffic. 12
Acute Intestinal Ischemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8590
ICD9CM 34 557.0
NCIt 46 C34356
UMLS 69 C0001363

Summaries for Acute Vascular Insufficiency of Intestine

MalaCards based summary : Acute Vascular Insufficiency of Intestine, also known as acute gastrointestinal tract vascular insuffic., is related to scorpion envenomation and angioimmunoblastic lymphadenopathy with dysproteinemia. An important gene associated with Acute Vascular Insufficiency of Intestine is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Acute Vascular Insufficiency of Intestine

Diseases related to Acute Vascular Insufficiency of Intestine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 scorpion envenomation 10.4 IL6 TNF
2 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
3 critical limb ischemia 10.4 IL6 TNF
4 streptococcal toxic-shock syndrome 10.3 IL6 TNF
5 recurrent corneal erosion 10.3 IL1B IL6
6 null-cell leukemia 10.3 IL6 TNF
7 bagassosis 10.3 IL1B IL6
8 periodontitis, chronic 10.3 IL1B IL6
9 polyposis, gastric 10.3 IL1B TNF
10 retinitis pigmentosa 55 10.3 IL6 TNF
11 glossitis 10.3 IL6 TNF
12 uremic pruritus 10.3 IL1B IL6
13 systemic onset juvenile idiopathic arthritis 10.3 IL1B TNF
14 ileitis 10.3 FABP2 IL6 TNF
15 funisitis 10.2 IL1B IL6
16 staphylococcal toxic shock syndrome 10.2 IL1B TNF
17 kashin-beck disease 10.2 IL1B TNF
18 euthyroid sick syndrome 10.2 IL1B IL6
19 cerebral hemorrhage 10.2 IL1B SOD1
20 anterior uveitis 10.2 IL6 TNF
21 louse-borne relapsing fever 10.2 IL6 MAPK1 TNF
22 vulvar vestibulitis syndrome 10.2 IL1B TNF
23 burns 10.2 IL1B TNF
24 ascaris lumbricoides infection 10.2 IL1B IL6
25 spinal cord injury 10.2 GDNF IL6 TNF
26 posterior urethral valves 10.2 IL6 TNF
27 spinal cord disease 10.1 GDNF SOD1 TNF
28 haemophilus influenzae 10.1 IL1B TNF
29 laryngitis 10.1 IL1B IL6 TNF
30 poems syndrome 10.1 IL1B IL6 TNF
31 burning mouth syndrome 10.1 IL1B IL6 TNF
32 central nervous system vasculitis 10.1 IL1B IL6 TNF
33 osteosclerotic myeloma 10.1 IL1B IL6 TNF
34 stachybotrys chartarum 10.1 IL1B IL6 TNF
35 endometritis 10.1 IL1B IL6 TNF
36 pulpitis 10.1 IL1B IL6 TNF
37 joint disorders 10.1 IL1B IL6 TNF
38 lacrimal apparatus disease 10.1 IL1B IL6 TNF
39 adult-onset still's disease 10.1 IL1B IL6 TNF
40 viral encephalitis 10.1 IL1B IL6 TNF
41 aphthous stomatitis 10.1 IL1B IL6 TNF
42 commensal bacterial infectious disease 10.1 IL1B IL6 TNF
43 acute respiratory distress syndrome 10.1 IL1B IL6 TNF
44 dengue shock syndrome 10.1 IL1B IL6 TNF
45 brain edema 10.1 IL1B IL6 SOD1
46 extrinsic cardiomyopathy 10.1 IL1B IL6 TNF
47 chikungunya 10.1 IL1B IL6 TNF
48 complex regional pain syndrome 10.1 IL1B IL6 TNF
49 uterine anomalies 10.1 IL1B IL6 TNF
50 keratoconjunctivitis sicca 10.1 IL1B IL6 TNF

Comorbidity relations with Acute Vascular Insufficiency of Intestine via Phenotypic Disease Network (PDN): (show all 23)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Aortic Aneurysm Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Intestinal Obstruction
Intestinal Perforation Intestinal Volvulus
Ischemic Heart Disease Paralytic Ileus
Peripheral Vascular Disease Peritonitis
Portal Vein Thrombosis Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Acute Vascular Insufficiency of Intestine:



Diseases related to Acute Vascular Insufficiency of Intestine

Symptoms & Phenotypes for Acute Vascular Insufficiency of Intestine

MGI Mouse Phenotypes related to Acute Vascular Insufficiency of Intestine:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.07 TJP1 CEP290 MAPK1 FABP2 GDNF OCLN
2 cardiovascular system MP:0005385 10.03 IL6 TJP1 CEP290 MAPK1 GDNF SOD1
3 endocrine/exocrine gland MP:0005379 9.95 IL6 MAPK1 GDNF OCLN HSPA4 SOD1
4 nervous system MP:0003631 9.85 TNF CEP290 MAPK1 GDNF OCLN HSPA4
5 liver/biliary system MP:0005370 9.8 IL6 CEP290 MAPK1 FABP2 SOD1 TNF
6 muscle MP:0005369 9.73 IL6 MAPK1 GDNF OCLN SOD1 TNF
7 reproductive system MP:0005389 9.56 TNF CEP290 MAPK1 GDNF OCLN HSPA4
8 skeleton MP:0005390 9.17 IL6 CEP290 MAPK1 OCLN SOD1 IL1B

Drugs & Therapeutics for Acute Vascular Insufficiency of Intestine

Drugs for Acute Vascular Insufficiency of Intestine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
2
Dalteparin Approved Phase 4 9005-49-6
3 calcium heparin Phase 4
4 Fibrinolytic Agents Phase 4
5 Heparin, Low-Molecular-Weight Phase 4
6 Anticoagulants Phase 4
7 Calcium, Dietary Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia Completed NCT02645240 Phase 4 Heparin injection
2 Liberal Transfusion Strategy in Elderly Patients Recruiting NCT03369210 Phase 3 red blood cell transfusion trigger
3 Plasma i-FABP as Predictor for Irreversible Bowel Ischemia Unknown status NCT01788904
4 Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study Recruiting NCT02772913

Search NIH Clinical Center for Acute Vascular Insufficiency of Intestine

Genetic Tests for Acute Vascular Insufficiency of Intestine

Anatomical Context for Acute Vascular Insufficiency of Intestine

Publications for Acute Vascular Insufficiency of Intestine

Variations for Acute Vascular Insufficiency of Intestine

Expression for Acute Vascular Insufficiency of Intestine

Search GEO for disease gene expression data for Acute Vascular Insufficiency of Intestine.

Pathways for Acute Vascular Insufficiency of Intestine

Pathways related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 GDNF HSPA4 IL1B IL6 TNF
2
Show member pathways
12.5 IL1B IL6 MAPK1 TNF
3
Show member pathways
12.49 IL1B IL6 MAPK1 TNF
4
Show member pathways
12.43 IL1B IL6 MAPK1 TNF
5
Show member pathways
12.34 IL1B IL6 MAPK1 TNF
6
Show member pathways
12.23 IL1B IL6 SOD1 TNF
7
Show member pathways
12.22 IL1B IL6 MAPK1 TNF
8
Show member pathways
12.13 IL1B IL6 MAPK1 TNF
9 12.11 IL1B IL6 MAPK1 TNF
10
Show member pathways
12.06 IL1B IL6 TNF
11 11.97 MAPK1 OCLN TNF
12 11.96 IL1B MAPK1 TNF
13 11.9 IL1B IL6 TNF
14 11.86 IL1B IL6 MAPK1
15
Show member pathways
11.84 IL1B IL6 TNF
16 11.81 IL1B IL6 TNF
17 11.79 IL1B IL6 TNF
18 11.77 IL1B IL6 MAPK1 TNF
19 11.76 IL1B IL6 TNF
20 11.66 IL1B IL6 TNF
21 11.66 IL1B IL6 MAPK1 TNF
22 11.59 IL1B IL6 TNF
23 11.56 IL1B IL6 MAPK1 TJP1
24 11.5 IL1B IL6 TNF
25 11.44 IL1B IL6 TNF
26 11.44 IL1B IL6 MAPK1 TNF
27 11.43 IL1B IL6 TNF
28 11.43 GDNF IL1B IL6 MAPK1 TNF
29 11.38 IL1B IL6 TNF
30
Show member pathways
11.26 IL1B IL6 MAPK1 TNF
31 11.24 IL1B IL6 TNF
32 11.23 IL1B IL6 TNF
33 11.18 IL1B IL6 TNF
34 11.14 IL1B IL6 TNF
35 11.11 IL1B IL6 TNF
36 11.07 MAPK1 TNF
37 11.03 IL6 TNF
38 10.96 IL6 TNF
39 10.92 IL1B MAPK1 TNF
40 10.87 IL1B TNF
41 10.73 IL1B IL6
42 10.47 IL1B IL6 MAPK1 SOD1

GO Terms for Acute Vascular Insufficiency of Intestine

Cellular components related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite cytoplasm GO:0032839 9.16 MAPK1 SOD1
2 protein complex GO:0043234 9.02 CEP290 GOT2 MAPK1 SOD1 TJP1
3 apicolateral plasma membrane GO:0016327 8.96 OCLN TJP1

Biological processes related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.92 GDNF IL1B IL6 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.91 CEP290 IL1B IL6 MAPK1 TNF
3 positive regulation of gene expression GO:0010628 9.89 IL1B IL6 MAPK1 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 IL1B IL6 TNF
5 MAPK cascade GO:0000165 9.78 GDNF IL1B MAPK1 TNF
6 response to ethanol GO:0045471 9.74 GOT2 SOD1 TJP1
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.71 IL1B IL6 TNF
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 IL1B TNF
9 positive regulation of chemokine production GO:0032722 9.6 IL6 TNF
10 negative regulation of lipid catabolic process GO:0050995 9.58 IL1B TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IL1B TNF
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.56 IL1B TNF
13 regulation of bicellular tight junction assembly GO:2000810 9.55 OCLN TJP1
14 positive regulation of interleukin-6 production GO:0032755 9.54 IL1B IL6 TNF
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.52 IL1B TNF
16 negative regulation of lipid storage GO:0010888 9.49 IL6 TNF
17 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
18 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
19 positive regulation of fever generation GO:0031622 9.4 IL1B TNF
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.33 GDNF IL1B TNF
21 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 IL1B MAPK1 TNF
24 activation of MAPK activity GO:0000187 8.92 IL1B MAPK1 SOD1 TNF

Sources for Acute Vascular Insufficiency of Intestine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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