MCID: ACT060
MIFTS: 35

Acute Vascular Insufficiency of Intestine malady

Categories: Gastrointestinal diseases, Cardiovascular diseases

Aliases & Classifications for Acute Vascular Insufficiency of Intestine

Aliases & Descriptions for Acute Vascular Insufficiency of Intestine:

Name: Acute Vascular Insufficiency of Intestine 12 14 69
Acute Gastrointestinal Tract Vascular Insuffic. 12
Acute Intestinal Vascular Insufficiency 12
Acute Git Vascular Insuffic. 12
Acute Intestinal Ischemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8590
ICD9CM 35 557.0
NCIt 47 C34356
UMLS 69 C0001363

Summaries for Acute Vascular Insufficiency of Intestine

MalaCards based summary : Acute Vascular Insufficiency of Intestine, also known as acute gastrointestinal tract vascular insuffic., is related to mesenteric artery ischemia and vps11-related autosomal recessive hypomyelinating leukodystrophy. An important gene associated with Acute Vascular Insufficiency of Intestine is FABP2 (Fatty Acid Binding Protein 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Acute Vascular Insufficiency of Intestine

Diseases related to Acute Vascular Insufficiency of Intestine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
id Related Disease Score Top Affiliating Genes
1 mesenteric artery ischemia 11.2
2 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
3 dyslexia 5 10.2 IL6 TNF
4 intussusception 10.2 IL1B TNF
5 oculomotor nerve paralysis 10.2 IL1B IL6
6 aortic atherosclerosis 10.2 IL6 TNF
7 common peroneal nerve lesion 10.2 IL1B IL6
8 degenerative disc disease 10.2 IL6 TNF
9 unilateral multicystic dysplastic kidney 10.2 IL6 TNF
10 crohn's colitis 10.2 FABP2 IL6 TNF
11 tau syndrome 10.2 IL1B TNF
12 thymic neuroendocrine carcinoma 10.2 IL6 TNF
13 cicatricial lagophthalmos 10.2 IL6 MAPK1 TNF
14 stocco dos santos syndrome 10.2 IL1B TNF
15 long bones of lower limb cancer 10.1 GDNF IL6 TNF
16 splenic marginal zone lymphoma 10.1 GDNF IL6 TNF
17 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.1 IL1B TNF
18 early yaws 10.1 GDNF IL1B IL6
19 anal paget's disease 10.1 IL1B IL6 TNF
20 bipolar i disorder 10.1 IL1B IL6 TNF
21 human immunodeficiency virus infectious disease 10.1 IL1B IL6 TNF
22 twin-to-twin transfusion syndrome 10.1 IL1B TNF
23 tinea capitis 10.1 IL1B IL6 TNF
24 dextrocardia 10.1 IL1B IL6 TNF
25 hypoparathyroidism-retardation-dysmorphism syndrome 10.1 IL1B IL6 TNF
26 steroid dehydrogenase deficiency dental anomalies 10.1 IL1B IL6 TNF
27 mikulicz disease 10.1 IL1B IL6 TNF
28 acquired thrombocytopenia 10.1 IL1B IL6 TNF
29 benign neonatal seizures 10.1 IL1B IL6 TNF
30 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.1 IL1B IL6 TNF
31 gonococcal endophthalmia 10.1 IL1B IL6 TNF
32 mineral metabolism disease 10.1 IL1B IL6 TNF
33 migraine with aura 10.1 IL1B IL6 TNF
34 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL1B IL6 TNF
35 bladder signet ring cell adenocarcinoma 10.1 IL1B IL6 TNF
36 keratoconus 10.1 IL1B IL6 TNF
37 motility-related diarrhea 10.1 IL1B IL6 TNF
38 splenic artery aneurysm 10.1 IL1B IL6 TNF
39 inappropriate adh syndrome 10.1 IL1B IL6 TNF
40 central nervous system lymphoma 10.1 IL1B IL6 TNF
41 histiocytoid hemangioma 10.1 IL1B IL6 SOD1
42 tuberculosis 10.1 IL1B IL6 TNF
43 labyrinthitis 10.1 IL1B IL6 TNF
44 pancreas lymphoma 10.1 IL1B IL6 TNF
45 atrophy of prostate 10.1 IL1B IL6 TNF
46 immunoglobulin g deficiency 10.1 IL1B IL6 TNF
47 blepharochalasis 10.1 IL1B IL6 TNF
48 chordoid meningioma 10.1 IL1B IL6 TNF
49 charcot-marie-tooth disease 10.1 IL1B SOD1
50 choroiditis 10.1 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Acute Vascular Insufficiency of Intestine:



Diseases related to Acute Vascular Insufficiency of Intestine

Symptoms & Phenotypes for Acute Vascular Insufficiency of Intestine

MGI Mouse Phenotypes related to Acute Vascular Insufficiency of Intestine:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 CEP290 GDNF IL1B IL6 MAPK1 SOD1
2 growth/size/body region MP:0005378 10.02 OCLN SOD1 TJP1 TNF CEP290 FABP2
3 endocrine/exocrine gland MP:0005379 9.95 GDNF HSPA4 IL6 MAPK1 OCLN SOD1
4 nervous system MP:0003631 9.85 TJP1 TNF CEP290 GDNF HSPA4 IL1B
5 liver/biliary system MP:0005370 9.8 CEP290 FABP2 IL6 MAPK1 SOD1 TNF
6 muscle MP:0005369 9.73 GDNF IL6 MAPK1 OCLN SOD1 TNF
7 reproductive system MP:0005389 9.56 CEP290 GDNF HSPA4 IL6 MAPK1 OCLN
8 skeleton MP:0005390 9.17 CEP290 IL1B IL6 MAPK1 OCLN SOD1

Drugs & Therapeutics for Acute Vascular Insufficiency of Intestine

Drugs for Acute Vascular Insufficiency of Intestine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
2
Dalteparin Approved Phase 4 9041-08-1
3 calcium heparin Phase 4
4 Heparin, Low-Molecular-Weight Phase 4
5 Fibrinolytic Agents Phase 4
6 Anticoagulants Phase 4
7 Calcium, Dietary Phase 4
8 Liver Extracts
9 glutamine Nutraceutical
10 arginine Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4
2 Predictive Factors of Intestinal Infraction in Acute Mesenteric Ischemia Recruiting NCT02645240 Phase 4
3 Plasma i-FABP as Predictor for Irreversible Bowel Ischemia Unknown status NCT01788904
4 Kidney and Intestinal Markers for Early Detection of Organ Injury After Endovascular Aortic Repair Completed NCT01915446
5 INtestinal Failure, multiPle Organ Failure ANd CItrulline Assessment Completed NCT02520440
6 Prognostic Indicators as Provided by the EPIC ClearView Completed NCT01476995
7 Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study Recruiting NCT02772913
8 Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders Recruiting NCT01758042
9 Portal Flow Pulsatility as a Risk Factor for Acute Kidney Injury After Cardiac Surgery Recruiting NCT02831907
10 Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines Terminated NCT01802099

Search NIH Clinical Center for Acute Vascular Insufficiency of Intestine

Genetic Tests for Acute Vascular Insufficiency of Intestine

Anatomical Context for Acute Vascular Insufficiency of Intestine

Publications for Acute Vascular Insufficiency of Intestine

Variations for Acute Vascular Insufficiency of Intestine

Expression for Acute Vascular Insufficiency of Intestine

Search GEO for disease gene expression data for Acute Vascular Insufficiency of Intestine.

Pathways for Acute Vascular Insufficiency of Intestine

Pathways related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 41)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 GDNF HSPA4 IL1B IL6 TNF
2
Show member pathways
12.49 IL1B IL6 MAPK1 TNF
3
Show member pathways
12.48 IL1B IL6 MAPK1 TNF
4
Show member pathways
12.34 IL1B IL6 MAPK1 TNF
5
Show member pathways
12.23 IL1B IL6 SOD1 TNF
6
Show member pathways
12.22 IL1B IL6 MAPK1 TNF
7
Show member pathways
12.13 IL1B IL6 MAPK1 TNF
8 12.11 IL1B IL6 MAPK1 TNF
9
Show member pathways
12.06 IL1B IL6 TNF
10 11.97 MAPK1 OCLN TNF
11 11.95 IL1B MAPK1 TNF
12 11.9 IL1B IL6 TNF
13
Show member pathways
11.85 IL1B IL6 TNF
14 11.84 IL1B IL6 MAPK1
15 11.8 IL1B IL6 TNF
16 11.79 IL1B IL6 TNF
17 11.77 IL1B IL6 MAPK1 TNF
18 11.76 IL1B IL6 TNF
19 11.67 IL1B IL6 TNF
20 11.66 IL1B IL6 MAPK1 TNF
21 11.58 IL1B IL6 TNF
22 11.56 IL1B IL6 MAPK1 TJP1
23 11.5 IL1B IL6 TNF
24 11.44 IL1B IL6 TNF
25 11.44 IL1B IL6 MAPK1 TNF
26 11.43 IL1B IL6 TNF
27 11.43 GDNF IL1B IL6 MAPK1 TNF
28 11.38 IL1B IL6 TNF
29
Show member pathways
11.26 IL1B IL6 MAPK1 TNF
30 11.24 IL1B IL6 TNF
31 11.23 IL1B IL6 TNF
32 11.18 IL1B IL6 TNF
33 11.14 IL1B IL6 TNF
34 11.11 IL1B IL6 TNF
35 11.06 MAPK1 TNF
36 11.02 IL6 TNF
37 10.96 IL6 TNF
38 10.92 IL1B MAPK1 TNF
39 10.87 IL1B TNF
40 10.83 IL1B IL6
41 10.47 IL1B IL6 MAPK1 SOD1

GO Terms for Acute Vascular Insufficiency of Intestine

Cellular components related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendrite cytoplasm GO:0032839 8.96 MAPK1 SOD1
2 apicolateral plasma membrane GO:0016327 8.62 OCLN TJP1

Biological processes related to Acute Vascular Insufficiency of Intestine according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 CEP290 IL1B IL6 MAPK1 TNF
2 positive regulation of gene expression GO:0010628 9.9 IL1B IL6 MAPK1 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B IL6 TNF
4 MAPK cascade GO:0000165 9.81 GDNF IL1B MAPK1 TNF
5 response to ethanol GO:0045471 9.79 GOT2 SOD1 TJP1
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.76 IL1B IL6 TNF
7 response to lipopolysaccharide GO:0032496 9.73 IL1B IL6 MAPK1 TJP1
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.64 IL1B TNF
9 muscle cell cellular homeostasis GO:0046716 9.63 IL6 SOD1
10 negative regulation of lipid catabolic process GO:0050995 9.62 IL1B TNF
11 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IL1B TNF
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.59 IL1B TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
15 positive regulation of protein import into nucleus, translocation GO:0033160 9.57 IL6 MAPK1
16 positive regulation of chemokine biosynthetic process GO:0045080 9.56 IL1B TNF
17 myeloid cell homeostasis GO:0002262 9.55 IL6 SOD1
18 positive regulation of interleukin-6 production GO:0032755 9.54 IL1B IL6 TNF
19 negative regulation of lipid storage GO:0010888 9.52 IL6 TNF
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 IL1B IL6 TNF
21 regulation of establishment of endothelial barrier GO:1903140 9.49 IL1B TNF
22 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.48 IL6 TNF
23 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
24 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
25 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.33 GDNF IL1B TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.13 IL1B MAPK1 TNF
28 activation of MAPK activity GO:0000187 8.92 IL1B MAPK1 SOD1 TNF

Sources for Acute Vascular Insufficiency of Intestine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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