MCID: ADM001
MIFTS: 26

Adamantinous Craniopharyngioma

Categories: Cancer diseases

Aliases & Classifications for Adamantinous Craniopharyngioma

MalaCards integrated aliases for Adamantinous Craniopharyngioma:

Name: Adamantinous Craniopharyngioma 12 14 69
Craniopharyngioma, Adamantinomatous 12
Adamantinous Rathke's Pouch Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3846
MeSH 41 D003397
NCIt 46 C4726
SNOMED-CT 64 128781004 134216001
UMLS 69 C0431129

Summaries for Adamantinous Craniopharyngioma

MalaCards based summary : Adamantinous Craniopharyngioma, also known as craniopharyngioma, adamantinomatous, is related to papillary craniopharyngioma and angiokeratoma circumscriptum, and has symptoms including visual disturbance An important gene associated with Adamantinous Craniopharyngioma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are G-Beta Gamma Signaling and Kaposi's sarcoma-associated herpesvirus infection. Affiliated tissues include endothelial, and related phenotype is respiratory system.

Related Diseases for Adamantinous Craniopharyngioma

Diseases related to Adamantinous Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 papillary craniopharyngioma 29.4 CTNNB1 DNAH12 DNAH2 DNAH7
2 angiokeratoma circumscriptum 10.3 MMP9 VEGFA
3 squamous cell carcinoma of the hypopharynx 10.3 MMP9 VEGFA
4 sick building syndrome 10.3 MMP9 VEGFA
5 microcystic meningioma 10.3 MMP9 VEGFA
6 adenomyosis 10.3 MMP9 VEGFA
7 odontogenic myxoma 10.3 MMP9 VEGFA
8 tuberculous meningitis 10.3 MMP9 VEGFA
9 rosacea 10.3 MMP9 VEGFA
10 arteriovenous malformation 10.2 MMP9 VEGFA
11 keratitis, hereditary 10.2 MMP9 VEGFA
12 psammomatous meningioma 10.2 CTNNB1 MMP9
13 microvascular complications of diabetes 1 10.1 MMP9 VEGFA
14 severe pre-eclampsia 10.1 MMP9 VEGFA
15 tongue squamous cell carcinoma 10.1 CTNNB1 MMP9
16 craniopharyngioma 10.1
17 endotheliitis 10.1
18 tongue cancer 10.0 CTNNB1 MMP9
19 ovarian cancer 1 10.0 CTNNB1 MMP9 VEGFA
20 female reproductive organ cancer 10.0 CTNNB1 MMP9 VEGFA
21 reproductive organ cancer 10.0 CTNNB1 MMP9 VEGFA
22 gastrointestinal system cancer 10.0 CTNNB1 MMP9 VEGFA
23 cell type cancer 10.0 CTNNB1 MMP9 VEGFA
24 oral squamous cell carcinoma 10.0 CTNNB1 MMP9 VEGFA
25 lung cancer susceptibility 3 9.9 CTNNB1 MMP9 VEGFA
26 exudative vitreoretinopathy 1 9.9 CTNNB1 VEGFA
27 nasopharyngeal carcinoma 9.9 CTNNB1 MMP9 VEGFA
28 endometrial adenocarcinoma 9.7 CTNNB1 VEGFA
29 central nervous system organ benign neoplasm 9.3 CTNNB1 DNAH2 DNAH7 HESX1

Graphical network of the top 20 diseases related to Adamantinous Craniopharyngioma:



Diseases related to Adamantinous Craniopharyngioma

Symptoms & Phenotypes for Adamantinous Craniopharyngioma

UMLS symptoms related to Adamantinous Craniopharyngioma:


visual disturbance

MGI Mouse Phenotypes related to Adamantinous Craniopharyngioma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 VEGFA ARL13B CTNNB1 HESX1 MMP9

Drugs & Therapeutics for Adamantinous Craniopharyngioma

Search Clinical Trials , NIH Clinical Center for Adamantinous Craniopharyngioma

Genetic Tests for Adamantinous Craniopharyngioma

Anatomical Context for Adamantinous Craniopharyngioma

MalaCards organs/tissues related to Adamantinous Craniopharyngioma:

38
Endothelial

Publications for Adamantinous Craniopharyngioma

Articles related to Adamantinous Craniopharyngioma:

# Title Authors Year
1
Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. ( 21814723 )
2011

Variations for Adamantinous Craniopharyngioma

Expression for Adamantinous Craniopharyngioma

Search GEO for disease gene expression data for Adamantinous Craniopharyngioma.

Pathways for Adamantinous Craniopharyngioma

GO Terms for Adamantinous Craniopharyngioma

Cellular components related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton GO:0005856 9.72 CTNNB1 DNAH12 DNAH2 DNAH7 TUBA4A
2 cell projection GO:0042995 9.67 ARL13B DNAH12 DNAH2 DNAH7
3 microtubule GO:0005874 9.46 DNAH12 DNAH2 DNAH7 TUBA4A
4 axonemal dynein complex GO:0005858 9.26 DNAH2 DNAH7
5 cilium GO:0005929 9.26 ARL13B DNAH12 DNAH2 DNAH7
6 dynein complex GO:0030286 8.8 DNAH12 DNAH2 DNAH7

Biological processes related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vasculogenesis GO:0001570 9.46 CTNNB1 VEGFA
2 dorsal/ventral pattern formation GO:0009953 9.43 ARL13B CTNNB1
3 cell maturation GO:0048469 9.4 CTNNB1 VEGFA
4 branching involved in blood vessel morphogenesis GO:0001569 9.37 CTNNB1 VEGFA
5 positive regulation of mesenchymal cell proliferation GO:0002053 9.32 CTNNB1 VEGFA
6 positive regulation of neuroblast proliferation GO:0002052 9.26 CTNNB1 VEGFA
7 macrophage differentiation GO:0030225 9.16 MMP9 VEGFA
8 cilium-dependent cell motility GO:0060285 8.96 DNAH2 DNAH7
9 microtubule-based movement GO:0007018 8.8 DNAH12 DNAH2 DNAH7

Molecular functions related to Adamantinous Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein light intermediate chain binding GO:0051959 9.37 DNAH2 DNAH7
2 dynein intermediate chain binding GO:0045505 9.32 DNAH2 DNAH7
3 dynein light chain binding GO:0045503 9.26 DNAH2 DNAH7
4 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.16 DNAH2 DNAH7
5 motor activity GO:0003774 9.13 DNAH12 DNAH2 DNAH7
6 microtubule motor activity GO:0003777 8.8 DNAH12 DNAH2 DNAH7

Sources for Adamantinous Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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