MCID: ADD001
MIFTS: 75

Addison's Disease malady

Endocrine diseases, Genetic diseases categories

Summaries for Addison's Disease

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 46OMIM, 32MalaCards
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MedlinePlus:33 Your adrenal glands are just above your kidneys. the outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. addison disease happens if the adrenal glands don't make enough of these hormones. a problem with your immune system usually causes addison disease. the immune system mistakenly attacks your own tissues, damaging your adrenal glands. other causes include infections and cancer. symptoms include weight loss muscle weakness fatigue that gets worse over time low blood pressure patchy or dark skin lab tests can confirm that you have addison disease. if you don't treat it, it can be fatal. you will need to take hormone pills for the rest of your life. if you have addison disease, you should carry an emergency id. it should say that you have the disease, list your medicines and say how much you need in an emergency. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Addison's Disease, also known as addison disease, is related to x-linked adrenal hypoplasia congenita and hypogonadism. An important gene associated with Addison's Disease is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Pregnenolone biosynthesis and Androgen biosynthesis. The drugs dexamethasone and fludrocortisone and the compounds estrogen and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, skin and testes, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:8 An adrenal cortical hypofunction that is characterized by insufficient steriod hormone production by the adrenal glands.

NIH Rare Diseases:42 Addison's disease is a condition that occurs when the adrenal glands do not produce enough of their hormones. this condition can be caused by damage to the adrenal glands, autoimmune conditions, and certain genetic conditions. some of the symptoms include changes in blood pressure, chronic diarrhea, darkening of the skin, paleness, extreme weakness, fatigue, nausea and vomiting, salt craving, and weight loss. treatment with replacement corticosteroids usually controls the symptoms. last updated: 4/28/2011

Description from OMIM:46 103230,240200

Aliases & Classifications for Addison's Disease

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
addison disease:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

addison's disease 8 42
addison disease 42 48 46 33 60
addisons disease 10 44
adrenocortical hypofunction, chronic primary congenital 8
addison disease, chronic adrenal insufficiency 8
addison's disease due to autoimmunity 60
primary adrenocortical insufficiency 8
adrenal cortical hypofunction 60
hypoadrenocorticism, familial 8
autoimmune addison's disease 48
hypoadrenocorticism familial 42
adrenal gland hypofunction 42
classic addison's disease 48
primary addison's disease 48
autoimmune adrenalitis 48
primary hypoadrenalism 8
adrenal hypoplasia 42
adrenal aplasia 42


External Ids:

Disease Ontology8 DOID:13774
NCIt39 C26689
MeSH34 D000224
MESH via Orphanet35 D000224
ICD10 via Orphanet26 E27.1
SNOMED-CT via Orphanet57 363732003, 76715008
UMLS via Orphanet61 C0001403, C0271737

Related Diseases for Addison's Disease

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17GeneCards, 18GeneDecks
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Diseases related to Addison's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1x-linked adrenal hypoplasia congenita30.9GK, STAR, NR0B1
2hypogonadism30.9NR0B1, CRH, GK, POMC
3triple-a syndrome30.3POMC, MC2R
4arthritis30.3PTPN22, CTLA4, POMC
5hypoadrenalism30.3CRH, POMC
6adrenoleukodystrophy30.2NR0B1, CYP21A2, REN, ABCD1
7hyperglycerolemia30.2GK2, NR0B1, GK
8duchenne muscular dystrophy30.2GK2, GK, NR0B1
9hypothyroidism30.2AIRE, POMC, CTLA4
10tuberculosis30.2CYP11A1, POMC
11achalasia30.2POMC, MC2R
12hypoparathyroidism30.2AIRE, CTLA4
13vitiligo30.2CTLA4, AIRE, PTPN22, POMC, DDC
14diabetes mellitus30.2POMC, CYP27B1, CTLA4, GK, REN, PTPN22
15adrenal carcinoma30.1POMC
16pseudohermaphroditism30.1CYP17A1, HSD3B2
17cushing's syndrome30.1CRH, POMC
18ovarian disease29.9STAR
19autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia29.9CYP11A1, CYP21A2, CYP17A1, AIRE, TPH1, DDC
20adrenal adenoma29.9CRH, POMC, CYP21A2, MC2R, REN, CYP11A1
21adenoma29.9CYP11A1, POMC, NR0B1, CRH, REN, CYP17A1
22metaphyseal dysplasia29.9NR0B1, AIRE
23hypospadias29.9CYP17A1, HSD3B2, CYP21A2
24leydig cell tumor29.9STAR, POMC, NR0B1, CYP11A1, CYP17A1, CYP21A2
25hyperandrogenism29.9CRH, HSD3B2, CYP17A1, POMC, CYP11A1, CYP21A2
26pituitary adenoma29.9NR0B1, CRH, MC2R, POMC
27adrenal cortical hypofunction10.7
28hypogonadotropism10.6
29intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies10.4
30pituitary hypoplasia10.4
31muscular dystrophy10.2
32waterhouse-friderichsen syndrome10.2
33polymyalgia rheumatica10.2
34congenital muscular dystrophy10.2
35hyperprolactinemia10.1
36chronic fatigue syndrome10.1
37myasthenia gravis10.1
38glucocorticoid deficiency, due to acth unresponsiveness10.1
39adrenal hypoplasia, congenital, with hypogonadotropic hypogonadism10.1
40inherited isolated adrenal insufficiency due to cyp11a1 deficiency10.1
41congenital adrenal hypoplasia of maternal cause10.1
42familial adrenal hypoplasia with absent pituitary luteinizing hormone10.1
43adrenocortical insufficiency, without ovarian defect10.1
44x-linked disease10.1
45autoimmune polyendocrinopathy type 210.1
46in situ carcinoma10.1
47image syndrome10.1
48isolated x-linked adrenal hypoplasia congenita10.1
49pulmonary tuberculosis10.1
50adrenocortical carcinoma10.0POMC

Graphical network of the top 20 diseases related to Addison's Disease:



Diseases related to addison's disease

Clinical Features for Addison's Disease

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46OMIM
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Clinical features from OMIM:

103230,240200

Clinical synopsis from OMIM:

103230

Drugs & Therapeutics for Addison's Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Addison's Disease

Search NIH Clinical Center for Addison's Disease

Search CenterWatch for Addison's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Addison's Disease

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Anatomical Context for Addison's Disease

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32MalaCards
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MalaCards organs/tissues related to Addison's Disease:

32
Adrenal gland, Skin, Testes, Kidney, Thyroid, Bone, Pituitary, Cortex, T cells, Adrenal cortex, Liver, Heart, Prostate, B cells

Animal Models for Addison's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Addison's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.5GK, CYP27B1, CYP11A1, MC2R, ABCD1
2MP:000538610.3GK, CRH, CRHBP, DDC, AIRE, POMC
3MP:000538710.2CTLA4, CRH, DDC, AIRE, POMC, CYP27B1
4MP:000537610.2TPH1, GK, CTLA4, CRH, STAR, DDC
5MP:000537810.2DDC, STAR, CRHBP, CRH, GK, AIRE
6MP:000539710.2CTLA4, CRH, AIRE, POMC, CYP27B1, MC2R
7MP:000363110.2CRH, DDC, AIRE, POMC, CYP11A1, MC2R
8MP:000538910.2STAR, NR0B1, AIRE, CYP17A1, CYP27B1, CYP11A1
9MP:00107689.9GK, CTLA4, STAR, DDC, AIRE, POMC

Publications for Addison's Disease

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50PubMed
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Articles related to Addison's Disease:

(show top 50)    (show all 525)
idTitleAuthorsYear
1
Altered Chemokine Th1/Th2 Balance in Addison's Disease: Relationship with Hydrocortisone Dosing and Quality of Life. (23918683)
2014
2
Addison's disease: a survey on 633 patients in Padova. (24014553)
2013
3
A rare cause of elevated liver enzymes: Addison's disease. (23794352)
2013
4
Nocturnal hypoglycemia identified by a continuous glucose monitoring system in patients with primary adrenal insufficiency (Addison's Disease). (22242902)
2012
5
Prolonged Dyspnea after Interscalene Block: Attributed to Undiagnosed Addison's Disease and Myasthenia Gravis. (21687552)
2011
6
Simultaneous evaluation of the circulating levels of both Th1 and Th2 chemokines in patients with autoimmune Addison's disease. (21169727)
2011
7
Correction: Addison's disease presenting with idiopathic intracranial hypertension in 24-year-old woman: a case report. (21078156)
2010
8
Twenty years of dysuria in a patient with Addison's disease: a case report. (19830040)
2009
9
Adrenal insufficiency secondary to tuberculosis: the value of telemedicine in the remote diagnosis of Addison's disease in Ebeye, Republic of the Marshall Islands. (19365922)
2009
10
Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison's disease in girls and women with Turner syndrome. (18088406)
2007
11
Screening for Addison's disease in patients with type 1 diabetes mellitus and recurrent hypoglycaemia. (17551075)
2007
12
Agitated depression successfully treated with electroconvulsive therapy combined with steroid cover in a patient with Addison's disease. (17324493)
2007
13
Genetic evaluation of Addison's disease in the Portuguese Water Dog. (16670022)
2006
14
A deceptive presentation: Addison's disease. (16972446)
2006
15
Addison's disease presenting as acute chest syndrome: case report and review of literature. (17111738)
2006
16
A haplotype of the CYP27B1 promoter is associated with autoimmune Addison's disease but not with Graves' disease in a UK population. (15956353)
2005
17
Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population. (16322396)
2005
18
Systemic scleroderma and Addison's disease. (15729976)
2005
19
Apparent Addison's disease following ileostomy. (16221109)
2005
20
Unique adrenal gland imaging features in Addison's disease caused by paracoccidioidomycosis. (14573459)
2003
21
Adaptation to Addison's disease in a child: a case study. (14610444)
2003
22
Addison's disease presenting as depression. (14510342)
2003
23
Additional association of intra-MHC genes, MICA and D6S273, with Addison's disease. (12392510)
2002
24
Isolated Pneumocystis carinii infection of adrenal glands causing Addison's disease in a non-immunocompromised adult. (11478273)
2001
25
Brittle Addison's disease: a new variation on a familiar theme. (10684330)
2000
26
Adrenoleukodystrophy presenting as Addison's disease in childhood. (11280230)
2000
27
Reversible cardiomyopathy associated with Addison's disease. (10744801)
2000
28
Is the prevalence of Addison's disease underestimated? (10323417)
1999
29
A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase. (9973524)
1999
30
Circulating levels of adrenomedullin in patients with Addison's disease before and after corticosteroid treatment. (9579224)
1998
31
Adrenal autoantibodies and organ-specific autoimmunity in patients with Addison's disease. (8959085)
1996
32
Addison's disease. Secondary adrenal failure in critically ill patients is underrecognised. (8761249)
1996
33
Adrenomyeloneuropathy: a rare cause of Addison's disease? (8824109)
1996
34
Clinical problem-solving: identifying Addison's disease. (8614434)
1996
35
Addison's disease caused by adrenal blastomycosis: a case report with fine needle aspiration (FNA) cytology. (8520008)
1995
36
Addison's disease. (10332384)
1995
37
Bone mineral density is reduced in female but not male subjects with Addison's disease. (8115069)
1994
38
Autoimmune Addison's disease. Analysis of autoantibody binding sites on human steroid 21-hydroxylase. (8405426)
1993
39
Disseminated infection due to Acremonium species in a patient with Addison's disease. (8448297)
1993
40
Experimental autoimmune adrenalitis: a murine model for Addison's disease. (1617104)
1992
41
Recovery of adrenocortical function following treatment of tuberculous Addison's disease. (1589379)
1992
42
Bilateral adrenal lymphoma presenting as Addison's disease and hypercalcaemia. (1874298)
1991
43
Addison's disease with nephrotic syndrome: an unusual presentation of malignancy. (2070173)
1991
44
Ossification of the auricle in Addison's disease. (2511265)
1989
45
Polyradiculoneuropathy in Addison's disease. Case report and review of literature. (558557)
1977
46
Primary adrenocortical insufficiency (Addison's disease). (193387)
1977
47
A clinical and immunological study of adrenocortical insufficiency (Addison's disease). (5340030)
1967
48
Observations on the size of lymphocytes in the blood in Addison's disease; panhypopituitarism, and Cushing's syndrome during treatment. (13050344)
1953
49
Chronic pyelonephritis simulating Addison's disease. (15413207)
1950
50
A Case of Melancholia, Associated with, and Perhaps Due to, Addison's Disease. (20744702)
1867

Genetic Variations for Addison's Disease

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Expression for genes affiliated with Addison's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Addison's Disease

Search GEO for disease gene expression data for Addison's Disease.

Pathways for genes affiliated with Addison's Disease

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Addison's Disease

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Addison's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CRHBP, TPH1
2acth 1-244410.8CYP11A1, CRH, CYP21A2, POMC, CYP17A1
3doca4410.8POMC, CYP17A1, CYP21A2, CYP11A1, REN
4Pregnenolone11 2411.8CYP11A1, CYP21A2, CYP17A1, HSD3B2
511 deoxycortisol4410.8CRH, POMC, CYP17A1, CYP21A2, REN
617-hydroxypregnenolone4410.7HSD3B2, POMC, CYP21A2, CYP17A1
7Corticotropin1110.7CRH, CYP27B1, MC2R, HSD3B2
8ketoconazole44 28 11 2413.7CYP11A1, CRH, POMC, CYP17A1, CYP27B1, CYP21A2
917-hydroxyprogesterone44 2411.7CYP11A1, REN, CYP17A1, POMC, CRH, HSD3B2
10cycloheximide4410.7STAR
113beta-hydroxysteroid4410.7CYP17A1, MC2R, CYP21A2, POMC, CYP11A1, STAR
12metyrapone59 44 1112.7CRH, POMC, CYP21A2, MC2R, TPH1
1321-deoxycortisol44 2411.7CYP17A1, POMC, CYP21A2
14aminoglutethimide44 1111.7MC2R, CYP21A2, POMC, CYP11A1
15dehydroepiandrosterone sulfate4410.7CYP11A1, CYP17A1, MC2R, CRH, HSD3B2, CYP21A2
16forskolin44 49 1112.7ABCD1, POMC, REN, CRH, STAR, CYP17A1
17corticosterone44 59 2412.7CYP11A1, CYP21A2, REN, CYP17A1, POMC, STAR
1811beta-hydroxysteroid4410.7HSD3B2, CRH, CYP17A1, CYP21A2, REN, MC2R
1917beta-hydroxysteroid4410.7HSD3B2, CYP11A1, CYP21A2, STAR, CYP17A1
20dhea4410.7CYP17A1, STAR, POMC, HSD3B2, CYP21A2, CYP11A1
21gnrh4410.7NR0B1, CRH, POMC, CYP11A1, CYP21A2, STAR
22norepinephrine44 11 2412.7DDC, POMC, GK, CYP21A2, TPH1
23catecholamine4410.7CYP21A2, POMC, DDC, CRH, REN, TPH1
24spironolactone49 44 59 28 1114.7CRH, REN, CYP21A2, POMC
25fludrocortisone44 28 1112.7POMC, CYP21A2, REN
26cortisol28 2411.7CYP21A2, HSD3B2, POMC
27androstenedione44 2411.7HSD3B2, CRH, STAR, POMC, CYP17A1, CYP21A2
28hydrocortisone44 2 59 1113.7CRHBP, POMC, CYP21A2, MC2R, REN, CRH
29acth4410.6CRHBP, CRH, HSD3B2, POMC, CYP21A2, CYP17A1
30chloramphenicol44 2 1112.6CYP21A2, DDC, CYP11A1, CRH, CYP17A1, CYP27B1
31ribonucleic acid4410.6MC2R, CYP11A1, CYP17A1, CRH, STAR, POMC
32estradiol44 11 2412.6CYP27B1, REN, CYP11A1, CYP21A2, CYP17A1, POMC
33cholesterol44 28 11 2413.6CYP11A1, HSD3B2, CTLA4, REN, STAR, NR0B1
34testosterone44 59 11 2413.6MC2R, CYP11A1, POMC, HSD3B2, CRH, STAR
35progesterone44 59 28 11 2414.6CYP21A2, STAR, HSD3B2, POMC, CYP17A1, CRHBP
36steroid4410.6HSD3B2, CTLA4, CRH, STAR, NR0B1, REN
375-hydroxytryptophan4410.6CRH, DDC, TPH1
38dexamethasone44 49 28 1113.6CYP17A1, MC2R, CYP11A1, CYP21A2, NR0B1, STAR
39cyclic amp44 2411.6CRH, NR0B1, CYP17A1, CYP27B1, CYP11A1, MC2R
40glycerol44 11 2412.6GK2, NR0B1, POMC, CRH, GK
41progestin4410.6CYP11A1, POMC, CYP17A1, STAR
42fenfluramine28 44 1112.6CRH, POMC, TPH1
43arginine4410.6POMC, PTPN22, TPH1, CYP21A2, REN, ABCD1
44homovanillic acid44 2411.5DDC, TPH1, CRH
45epinephrine44 11 2412.4CRH, DDC, POMC, CYP21A2, REN
465-hydroxyindoleacetic acid44 2411.4CRH, TPH1, DDC
47benzodiazepine4410.4GK, CRH, STAR
48cortisone44 2411.3CYP21A2, POMC, CRH
49tyrosine4410.3CTLA4, PTPN22, DDC, AIRE, CYP21A2, CYP27B1
50lipid4410.0CTLA4, STAR, CYP11A1, GK, CYP17A1, CYP21A2

GO Terms for genes affiliated with Addison's Disease

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16Gene Ontology
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Cellular components related to Addison's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00574110.4CYP27B1, GK, GK2
2perikaryonGO:04320410.4CYP11A1, CRHBP, CRH
3mitochondrial cristaGO:03006110.3CYP11A1, STAR
4varicosityGO:04319610.1CRH, CRHBP

Biological processes related to Addison's Disease according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1response to fungicideGO:06099210.8STAR, CYP17A1, CYP11A1
2dibenzo-p-dioxin metabolic processGO:01889410.8STAR, CYP17A1, CYP11A1
3biphenyl metabolic processGO:01887910.8STAR, CYP17A1, CYP11A1
4Leydig cell differentiationGO:03332710.8CYP11A1, CYP17A1, NR0B1
5sterol metabolic processGO:01612510.8CYP17A1, CYP21A2, CYP11A1
6fractalkine metabolic processGO:05075610.8STAR, CYP11A1
7phthalate metabolic processGO:01896310.8STAR, CYP17A1, CYP11A1
8phenol-containing compound metabolic processGO:01895810.8STAR, CYP17A1, CYP11A1
9glucocorticoid biosynthetic processGO:00670410.8HSD3B2, CRH, CYP17A1, CYP21A2
10cellular response to antibioticGO:07123610.8STAR, CYP17A1, CYP11A1
11steroid biosynthetic processGO:00669410.8HSD3B2, STAR, NR0B1, CYP17A1
12cellular response to cocaineGO:07131410.8CRH, CRHBP
13serotonin biosynthetic processGO:04242710.8TPH1, DDC
14adrenal gland developmentGO:03032510.8CYP17A1, NR0B1, CRH
15response to corticosterone stimulusGO:05141210.8CYP11A1, STAR, CRH
16response to insecticideGO:01708510.8CYP17A1, CYP11A1
17response to immobilization stressGO:03590210.8CRH, TPH1
18glycerol catabolic processGO:01956310.8GK2, GK
19xenobiotic metabolic processGO:00680510.8CYP17A1, CYP27B1, CYP21A2, CYP11A1
20steroid metabolic processGO:00820210.8CYP11A1, CYP21A2, CYP27B1, CYP17A1, STAR, HSD3B2
21testosterone biosynthetic processGO:06137010.8STAR, CYP11A1
22mineralocorticoid biosynthetic processGO:00670510.8HSD3B2, CYP21A2
23diterpenoid metabolic processGO:01610110.8CRH, STAR
24cellular response to cAMPGO:07132010.8CYP11A1, STAR, CRHBP
25indolalkylamine biosynthetic processGO:04621910.7DDC, TPH1
26cellular response to drugGO:03569010.7CRHBP, DDC, REN
27C21-steroid hormone biosynthetic processGO:00670010.7CYP11A1, STAR
28cellular response to alkaloidGO:07131210.7STAR, DDC
29progesterone biosynthetic processGO:00670110.7CYP11A1, STAR
30response to estrogen stimulusGO:04362710.7CYP27B1, STAR, CRH
31response to herbicideGO:00963510.7CYP17A1, STAR
32cellular response to follicle-stimulating hormone stimulusGO:07137210.7CYP11A1, STAR
33cellular response to lipopolysaccharideGO:07122210.7STAR, CYP17A1, CYP11A1
34cellular response to dexamethasone stimulusGO:07154910.7STAR, CRH
35estrogen biosynthetic processGO:00670310.6STAR, CYP11A1
36small molecule metabolic processGO:04428110.6HSD3B2, GK, STAR, DDC, CYP17A1, CYP27B1
37vitamin D metabolic processGO:04235910.6CYP11A1, CYP27B1
38male gonad developmentGO:00858410.6REN, NR0B1, STAR
39regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.6CRH, CRHBP
40androgen biosynthetic processGO:00670210.5HSD3B2, CYP17A1
41synaptic transmission, dopaminergicGO:00196310.5CRH, CRHBP
42glycerol metabolic processGO:00607110.4GK, GK2
43response to drugGO:04249310.4CRH, STAR, CYP17A1, CYP11A1
44hypothalamus developmentGO:02185410.3NR0B1, CRH
45cellular response to cadmium ionGO:07127610.1CYP11A1, STAR

Molecular functions related to Addison's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:00905510.4CYP11A1, CYP21A2, CYP27B1, CYP17A1
2iron ion bindingGO:00550610.4TPH1, CYP11A1, CYP21A2, CYP27B1, CYP17A1
3heme bindingGO:02003710.3CYP17A1, CYP27B1, CYP21A2, CYP11A1
4glycerol kinase activityGO:00437010.1GK, GK2

Products for genes affiliated with Addison's Disease

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Sources for Addison's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet