Addison's Disease malady

MedlinePlus: Your adrenal glands are just above your kidneys. the outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. addison's disease occurs if the adrenal glands don't make enough of these hormones. a problem with your immune system usually causes addison's disease. the immune system mistakenly attacks your own tissues, damaging your adrenal glands. symptoms include weight loss muscle weakness fatigue that gets worse over time low blood pressure patchy or dark skin lab tests can confirm that you have addison's disease. if you don't treat it, it can be fatal. you will need to take hormone pills for the rest of your life. if you have addison's disease, you should carry an emergency id. it should say that you have the disease, list your medicines and say how much you need in an emergency.²³

MalaCards: Addison's Disease, also known as addisons disease, is related to adrenal hypoplasia and x-linked adrenal hypoplasia congenita. An important gene associated with Addison's Disease is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Cell adhesion molecules (CAMs) and Steroid hormone biosynthesis. The drugs fludrocortisone and dexamethasone and the compounds glucose and doca have been mentioned in the context of this disorder. Affiliated tissues include cortex, kidney and liver, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

NIH Rare Diseases: Addison's disease is a condition that occurs when the adrenal glands do not produce enough of their hormones. This condition can be caused by damage to the adrenal glands, autoimmune conditions, and certain genetic conditions. Some of the symptoms include changes in blood pressure, chronic diarrhea, darkening of the skin, paleness, extreme weakness, fatigue, nausea and vomiting, salt craving, and weight loss. Treatment with replacement corticosteroids usually controls the symptoms.³⁰

Aliases & Descriptions:

addison's disease 6 30 17 23 addisons disease 8 32 addison disease 30 43 primary adrenocortical insufficiency (disorder) 6 addison's disease (disorder) 6 hypoadrenocorticism familial 30

adrenal gland hypofunction 30 primary hypoadrenalism 6 addison's disease, nos 6 addison's disease nos 6 adrenal hypoplasia 30 adrenal aplasia 30

Diseases related to addison's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 659)

id	Related Disease	Score	Top Affiliating Genes
1	adrenal hypoplasia	37.9	REN, IL1RAPL1, MC2R, GK, GK2, ESRRB
2	x-linked adrenal hypoplasia congenita	37.6	REN, GK, GK2, NR0B1, POMC
3	glycerol kinase deficiency	33.6	IL1RAPL1, GK, GK2, DMD, NR0B1
4	autoimmune polyendocrine syndrome	33.5	INS, AIRE, TPH1, TPO, DDC, CYP21A2
5	dosage-sensitive sex reversal	33.0	ESRRB, CYP11A1, NR0B1, NR1H2, NR3C1, NR5A1
6	sex reversal	32.8	ESRRB, CYP11A1, NR0B1, NR1H2, NR3C1, NR5A1
7	hypogonadotropism	31.8	PCSK1, BGLAP, KAL1, INS, GNRHR, GK
8	hypogonadism	31.2	PCSK1, SERPINA6, VDR, BGLAP, KAL1, INS
9	premature ovarian failure	31.0	HSD3BP4, TPO, CYP11A1, SHBG, STAR, PRL
10	autoimmune polyendocrine syndrome type 1	30.7	AIRE, TPH1, CYP21A2
11	21-hydroxylase deficiency	30.2	HSD3B2, HLA-B, CYP11B2, CYP11A1, CYP17A1, CYP21A2
12	turner syndrome	30.0	BGLAP, TPO, DMD, CYP21A2, SHBG, TG
13	orthostatic hypotension	30.0	REN, DDC, NPPA
14	lipoid adrenal hyperplasia	29.9	CYP11A1, NR0B1, STAR, POMC
15	complex glycerol kinase deficiency	29.8	IL1RAPL1, GK, GK2, DMD, NR0B1
16	hypoadrenalism	29.7	PCSK1, INS, CRH, SHBG, TG, POMC
17	celiac disease	29.4	CLEC16A, HLA-DQA1, HLA-DQB1, HLA-DRB1, CTLA4
18	adrenoleukodystrophy	29.1	AMN, HLA-DRB1, CYP21A2, NR0B1, NR5A1, ABCD1
19	adrenocortical insufficiency	28.9	INS, CYP21A2, NR5A1, CRH, STAR, POMC
20	pituitary hormone deficiency	28.5	INS, NR0B1, NR5A1, CRH, PRL, POMC
21	pseudohermaphroditism	28.4	HSD3B2, HSD3BP4, CYP17A1, CYP21A2, NR0B1, NR3C1
22	postural hypotension	28.4	REN, INS, DDC, SST, ABCB1, NPPA
23	duchenne muscular dystrophy	28.2	F2, GK, HLA-A, HLA-B, HLA-DRB1, DMD
24	muscular dystrophy	28.0	INS, MC2R, F2, GK, GK2, HLA-A
25	aldosteronism	27.8	REN, SERPINA6, SCARB1, CHGA, S100A6, INS
26	hyperandrogenism	27.1	REN, INS, HSD3B2, HSD11B1, HSD3BP4, CYP11A1
27	adrenal hyperplasia	26.0	REN, MRAP, INS, MC2R, HSD3B2, HSD3BP4
28	graves' disease	25.8	PDCD1, VDR, BGLAP, CD79A, CD274, FOXP3
29	sarcoidosis	25.1	VDR, CD79A, FOXP3, FCGR3A, CCR2, CCR5
30	type 1 diabetes mellitus	24.3	PDCD1, VDR, BGLAP, CD79A, INS, CCR5
31	adenoma	20.7	REN, PCSK1, VDR, BGLAP, SCARB1, CHGA
32	thyroiditis	19.7	REN, PCSK1, SERPINA6, VDR, CLEC16A, BGLAP
33	diabetes mellitus	18.6	PDCD1, REN, PCSK1, VDR, CLEC16A, BGLAP
34	3-beta-hydroxysteroid dehydrogenase deficiency	13.9	HSD3B2, HSD3BP4, CYP17A1, CYP21A2
35	17-alpha-hydroxylase deficiency	13.9	REN, CYP11B2, CYP17A1
36	17-alpha-hydroxylase/17,20-lyase deficiency	13.9	CYP17A1, POR, POMC
37	late-onset congenital adrenal hyperplasia	13.9	HSD3BP4, CYP21A2, POMC
38	adrenocortical hyperplasia	13.9	MC2R, CYP11B2, CYP11A1, CYP21A2, CRH, POMC
39	xy sex reversal	13.9	CYP11A1, NR0B1, NR5A1, STAR
40	lipoid congenital adrenal hyperplasia	13.9	MRAP, CYP11A1, NR5A1, STAR, POR
41	disorders of sex development	13.9	CYP21A2, NR0B1, NR5A1, WT1
42	hypothyroidism, autoimmune	13.9	AIRE, TPO, CTLA4
43	gonadal disease	13.9	NR5A1, CRH, POMC
44	adrenocorticotropic hormone deficiency	13.9	PCSK1, CRH, POMC
45	46, xy disorders of sexual development	13.9	CYP17A1, NR5A1, WT1, STAR
46	antley-bixler syndrome	13.9	CYP17A1, CYP21A2, POR, POMC
47	familial glucocorticoid deficiency	13.8	REN, MRAP, MC2R, NR0B1, STAR, POMC
48	cerebellar hypoplasia	13.8	KAL1, GK, ESRRB, CYP11A1, NR0B1, NR5A1
49	46, xy disorders of sex development	13.8	NR0B1, NR5A1, WT1
50	kallmann syndrome	13.8	PCSK1, KAL1, GNRHR, ESRRB, NR0B1, NR5A1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], fludrocortisone, fludrocortisone acetate

MalaCards organs/tissues related to addison's disease:

²²

MGI Mouse Phenotypes related to addison's disease:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	PCSK1, MC2R, GNRHR, AIRE, TRH, DMD
2	respiratory system phenotype	MP:0005388	9.8	POR, TH, CRH, DMD, PTPN22, TPH1
3	hematopoietic system phenotype	MP:0005397	9.4	TG, DMD, PTPN22, TNFRSF25, HLA-DQB1, HLA-DQA1
4	renal/urinary system phenotype	MP:0005367	8.9	CYP11B2, CYP27B1, WT1, OXT, POR, NPPA
5	no phenotypic analysis	MP:0003012	8.4	POMC, SST, DMD, AIRE, ESRRB, CCR5
6	reproductive system phenotype	MP:0005389	8.4	NR5A1, WT1, ABCD1, STAR, OXT, PRL
7	integument phenotype	MP:0010771	8.2	POMC, PRL, OXT, TH, CRH, NR3C1
8	growth/size phenotype	MP:0005378	7.8	CRH, NR5A1, NR3C1, SST, CYP27B1, CRHBP
9	liver/biliary system phenotype	MP:0005370	7.7	CTLA4, NR1H2, ABCB1, ABCB7, TH, PRL
10	immune system phenotype	MP:0005387	7.5	AIRE, GAST, HLA-DQA1, HLA-DQB1, TNFRSF25, PTPN22
11	normal phenotype	MP:0002873	7.4	SST, CTLA4, NR1H2, NR3C1, NR5A1, CRH
12	nervous system phenotype	MP:0003631	7.3	NR3C1, NR5A1, CRH, ABCB7, TH, TG
13	digestive/alimentary phenotype	MP:0005381	7.3	DMD, SST, SSTR2, CTLA4, NR3C1, OXT
14	cardiovascular system phenotype	MP:0005385	5.9	NR5A1, NR3C1, NR1H2, CTLA4, SSTR2, CYP11B2
15	mortality/aging	MP:0010768	5.8	CYP17A1, CYP11A1, CYP11B2, DDC, DMD, PTPN22
16	behavior/neurological phenotype	MP:0005386	5.8	SERPINA6, CD274, FOXP3, FKBP5, INS, MC2R
17	cellular phenotype	MP:0005384	5.7	NR1H2, CTLA4, CYP27B1, CYP11A1, CYP11B2, DDC
18	homeostasis/metabolism phenotype	MP:0005376	2.9	REN, GNRHR, HSD11B1, GK, AIRE, HLA-DQB1

Articles related to addison's disease:

(show top 50)    (show all 95)

id	Title	Authors	Year	Affiliating Genes
1	Dominant suppression of Addison's disease associated with HLA-B15. (21565792)	Baker P.R.... Eisenbarth G.S.	2011	HLA-B
2	Chromogranin A as a useful neuroendocrine marker in p atients with autoimmune Addison's disease. (19794299)	El Ali Z.... GrzymisA8awski M.	2010	CHGA, GAST
3	Autoimmunity predominates in a large South African co hort with addison's disease of mainly European descent despite long-standing di sease and is associated with HLA DQB*0201. (20455895)	Ross I.... Schatz D.	2010	HLA-DQB1
4	Isolated Addison's disease is unlikely to be caused b y mutations in MC2R, MRAP or STAR, three genes responsible for familial glucoco rticoid deficiency. (19903795)	Dias R.P.... Clark A.J.	2010	MC2R, STAR, MRAP
5	The low-dose (1 microg) cosyntropin test (LDT) for pr imary adrenocortical insufficiency: Defining the normal cortisol response and r eport on first patients with Addison disease confirmed with LDT. (19358090)	Pura M.... Vanuga P.	2010	CYP21A2
6	A coding variant in NLRP1 is associated with autoimmu ne Addison's disease. (20152874)	Zurawek M.... Nowak J.	2010	NLRP1
7	Programmed death ligand 1 (PD-L1) gene variants contr ibute to autoimmune Addison's disease and Graves' disease susceptibility. (19850680)	Mitchell A.L.... Pearce S.H.	2009	CD274
8	Metabolic and cardiovascular profile in patients with Addison's disease under conventional glucocorticoid replacement. (19620820)	Giordano R.... Arvat E.	2009	POMC, INS
9	Immunology of Addison's disease and premature ovarian failure. (19328418)	Husebye E.S.... vAYs K.	2009	CYP21A2
10	Autoimmune polyendocrine syndrome type I in Slovakia: relevance of screening patients with autoimmune Addison's disease. (18426830)	F Magitta N.... Husebye E.S.	2008	AIRE
11	Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II. (18620562)	Ramos-Lopez E.... Badenhoop K.	2008	INS
12	Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. (18301444)	Skinningsrud B.... Undlien D.E.	2008	PTPN22
13	Plasma galanin, vasopressin, and oxytocin in patients with Addison's disease. (17712724)	Grenback E.... Petersson M.	2007	POMC, GAL, OXT
14	Mechanism of inhibition of cytochrome P450 C21 enzyme activity by autoantibodies from patients with Addison's disease. (15762192)	Nikfarjam L.... Furmaniak J.	2005	POR, CYP21A2
15	Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population. (16322396)	Kahles H.... Badenhoop K.	2005	PTPN22, CTLA4
16	A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans. (15296474)	Lopez E.R.... Badenhoop K.	2004	CYP27B1
17	Adrenal lymphoma and Addison's disease: report of a case. (12632819)	Lu J.Y.... Chang Y.L.	2002	POMC
18	Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease. (12072047)	Pani M.A.... Badenhoop K.	2002	HLA-DQB1
19	Mutational analysis of the autoimmune regulator (AIRE) gene in sporadic autoimmune Addison's disease can reveal patients with unidentified autoimmune polyendocrine syndrome type I. (11916620)	Boe A.S.... Husebye E.S.	2002	AIRE
20	Additional association of intra-MHC genes, MICA and D6S273, with Addison's disease. (12392510)	Park Y.S.... Eisenbarth G.S.	2002	HLA-DRB1, MICA
21	Screening for an AIRE-1 mutation in patients with Addison's disease, type 1 diabetes, Graves' disease and Hashimoto's thyroiditis as well as in APECED syndrome. (11298085)	Meyer G.... Badenhoop K.	2001	AIRE
22	Low dose (1 microg) ACTH test in the evaluation of adrenal dysfunction in pre-clinical Addison's disease. (10931087)	Laureti S.... Falorni A.	2000	CYP21A2
23	Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease. (10690877)	Vaidya B.... Pearce S.H.	2000	AIRE, CTLA4
24	Autoantibodies against aromatic L-amino acid decarboxylase identifies a subgroup of patients with Addison's disease. (10634424)	Soderbergh A.... Husebye E.S.	2000	DDC, AIRE
25	DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. (9920103)	Yu L.... Eisenbarth G.S.	1999	CYP21A2
26	The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease. (10323386)	Hangaard J.... Hagen C.	1999	PRL, TRH
27	A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase. (9973524)	Nikoshkov A.... Luthman H.	1999	CYP21A2
28	Corticotropin-releasing effect of hexarelin, a peptidyl GH secretagogue, in normal subjects pretreated with metyrapone or RU-486, a glucocorticoid receptor antagonist, and in patients with Addison's disease. (10516483)	Arvat E.... Ghigo E.	1999	NR3C1
29	Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison's disease and autoimmune polyendocrine syndrome type II. (10376448)	Seissler J.... Scherbaum W.A.	1999	CYP21A2
30	Spontaneous intracerebral hemorrhage revealing Addison's disease. (9684065)	Derex L.... Trouillas P.	1998	F2
31	A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients. (10197076)	Kemp E.H.... Weetman A.P.	1998	CYP2D6, CTLA4
32	I. Adrenal cortex and steroid 21-hydroxylase autoantibodies in adult patients with organ-specific autoimmune diseases: markers of low progression to clinical Addison's disease. (9062509)	Betterle C.... Presotto F.	1997	CYP11A1, CYP21A2
33	21-hydroxylase autoantibodies in adult patients with endocrine autoimmune diseases are highly specific for Addison's disease. Belgian Diabetes Registry. (9030873)	Falorni A.... Santeusanio F.	1997	CYP21A2
34	II. Adrenal cortex and steroid 21-hydroxylase autoantibodies in children with organ-specific autoimmune diseases: markers of high progression to clinical Addison's disease. (9062510)	Betterle C.... Presotto F.	1997	CYP21A2
35	Adrenal autoantibodies and organ-specific autoimmunity in patients with Addison's disease. (8959085)	SAPderbergh A.... KAompe O.	1996	CYP21A2
36	Atrial natriuretic peptide and plasma renin levels in assessment of mineralocorticoid replacement in Addison's disease. (8636343)	Cohen N.... Jerums G.	1996	NPPA
37	Associated autoimmunity in Addison's disease. (7734032)	Zelissen P.M.... Croughs R.J.	1995	TG
38	Effect of atrial natriuretic factor infusion on basal and CRH-stimulated ACTH, cortisol and aldosterone levels in patients with Cushing's or Addison's disease. (8013139)	Ambrosi B.... Faglia G.	1994	POMC, REN, INS
39	Autoimmune Addison's disease--evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency. (7962352)	Furmaniak J.... Smith B.R.	1994	CYP21A2
40	Bone density and turnover in Addison's disease: effect of glucocorticoid treatment. (7950508)	Valero M.A.... Hawkins F.	1994	BGLAP
41	Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. (8106620)	Uibo R.... Krohn K.J.	1994	CYP17A1, CYP11A1, CYP21A2
42	Autoantibody epitope mapping of the 21-hydroxylase antigen in autoimmune Addison's disease. (7513715)	Song Y.H.... Maclaren N.	1994	CYP21A2, HSD3BP4
43	Acutely raised corticotropin levels in Addison's disease are not associated with increased plasma arginine vasopressin and corticotropin-releasing factor concentrations in peripheral plasma. (8380605)	Wittert G.A.... Espiner E.A.	1993	POMC, CRH
44	Autoimmune Addison's disease. Analysis of autoantibody binding sites on human steroid 21-hydroxylase. (8405426)	Wedlock N.... Furmaniak J.	1993	CYP21A2
45	Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17 alpha-hydroxylase. (1347802)	Krohn K.... Savilahti K.	1992	CYP17A1
46	Diagnosis and therapy surveillance in Addison's disease: rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone. (1320051)	Oelkers W.... Bahr V.	1992	POMC, REN, S100A6
47	21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. (1351548)	Winqvist O.... Kampe O.	1992	CYP21A2
48	Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease. (1511745)	Bednarek J.... Rees Smith B.	1992	CYP21A2
49	Inappropriate secretion of adrenocorticotropin from corticotroph hyperplasia in a case of Addison's disease. (2170722)	Miyabo S.... Kubota N.	1990	POMC
50	Polyglandular autoimmune syndrome type II in patients with idiopathic Addison's disease. (2333733)	Papadopoulos K.I.... Hallengren B.	1990	INS

Genes related to addison's disease according to GeneCards:

(show top 50)    (show all 83)

id	Symbol	Description	Score	GeneCards Section Context
1	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
2	GK2	glycerol kinase 2	11.0
3	AIRE	autoimmune regulator	11.0	Publications
4	ABCD1	ATP-binding cassette, sub-family D (ALD), member 1	11.0
5	CRHBP	corticotropin releasing hormone binding protein	11.0
6	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.0	Publications
7	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	11.0	Publications
8	GK	glycerol kinase	11.0
9	MC2R	melanocortin 2 receptor (adrenocorticotropic hormone)	11.0	Publications
10	HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	11.0
11	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
12	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
13	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	11.0	Publications
14	STAR	steroidogenic acute regulatory protein	11.0	Publications
15	TPH1	tryptophan hydroxylase 1	11.0	Publications
16	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	11.0	Publications
17	KAL1	Kallmann syndrome 1 sequence	11.0
18	ESRRB	estrogen-related receptor beta	11.0
19	GNRHR	gonadotropin-releasing hormone receptor	11.0
20	POR	P450 (cytochrome) oxidoreductase	11.0	Publications
21	POMC	proopiomelanocortin	11.0	Publications
22	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0
23	PCSK1	proprotein convertase subtilisin/kexin type 1	11.0
24	CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	11.0
25	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
26	CRH	corticotropin releasing hormone	11.0	Publications
27	WT1	Wilms tumor 1	11.0
28	TG	thyroglobulin	11.0	Publications
29	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0
30	TH	tyrosine hydroxylase	11.0	Publications
31	TPO	thyroid peroxidase	11.0	Publications
32	REN	renin	11.0	Publications
33	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0	Publications
34	SCARB1	scavenger receptor class B, member 1	11.0
35	IL1RAPL1	interleukin 1 receptor accessory protein-like 1	11.0
36	DMD	dystrophin	11.0
37	MRAP	melanocortin 2 receptor accessory protein	11.0	Publications
38	AMN	amnionless homolog (mouse)	11.0
39	NUDT10	nudix (nucleoside diphosphate linked moiety X)-type motif 10	11.0
40	HSD3BP4	hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4	11.0	Publications
41	MICB	MHC class I polypeptide-related sequence B	11.0	Publications
42	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	11.0
43	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0	Publications
44	S100A6	S100 calcium binding protein A6	11.0	Publications
45	MICA	MHC class I polypeptide-related sequence A	11.0	Publications
46	PDCD1	programmed cell death 1	11.0	Publications
47	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	11.0	Publications
48	SSTR2	somatostatin receptor 2	11.0	Publications
49	TRH	thyrotropin-releasing hormone	11.0	Publications
50	NLRP1	NLR family, pyrin domain containing 1	11.0	Publications

Pathways related to addison's disease according to GeneDecks:

(show all 21)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.6	CTLA4, CD226
2	Steroid hormone biosynthesis20	10.4	CYP21A2, CYP17A1, CYP11A1, CYP11B2, HSD11B1, HSD3B2
3	Metabolism of lipids and lipoproteins38	10.2	STAR, ABCD1, CYP27B1, CYP21A2, CYP17A1, CYP11A1
4	Development_Role of Activin A in cell differentiation and proliferation41	10.2	STAR, NR5A1, CYP11A1, GNRHR, VDR
5	Development Role of Activin A in cell differentiation and proliferation10	10.1	STAR, NR5A1, CYP11A1, GNRHR, VDR
6	CTLA4 Signaling36	9.7	CTLA4, PTPN22, HLA-DRB1, HLA-DQB1, HLA-DQA1
7	Staphylococcus aureus infection20	9.6	HLA-DRB1, HLA-DQB1, HLA-DQA1, FCGR3B, FCGR3A, FCGR2A
8	Antigen processing and presentation20	9.6	HLA-DQA1, HLA-DQB1, HLA-DRB1
9	Graft-versus-host disease20	9.6	HLA-DQA1, HLA-B, HLA-A
10	Immune System38	9.6	NLRP1, CTLA4, CCR2, FCGR3A, MICB, CD274
11	Leishmaniasis20	9.6	HLA-DRB1, HLA-DQB1, HLA-DQA1, FCGR3B, FCGR3A, FCGR2A
12	Selected targets of CREB110	9.4	REN, GAL, CRH, CCR5, MC2R, FCGR2A
13	Tuberculosis20	9.3	CYP27B1, HLA-DRB1, HLA-DQB1, HLA-DQA1, FCGR3B, FCGR3A
14	Natural killer cell mediated cytotoxicity20	9.3	MICB, MICA, FCGR3A, FCGR3B, HLA-A, HLA-B
15	CTL Mediated Apoptosis36	9.2	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
16	Autoimmune thyroid disease20	9.1	TG, CTLA4, TPO, HLA-DRB1, HLA-DQB1, HLA-DQA1
17	Viral myocarditis20	9.1	DMD, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
18	Allograft rejection20	9.1	HLA-A, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1
19	Systemic lupus erythematosus20	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, FCGR3B, FCGR3A, FCGR2A
20	Phagosome20	8.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A, FCGR3B
21	Type I diabetes mellitus20	8.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A, INS

Compounds related to addison's disease according to GeneDecks:

(show top 50)    (show all 308)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.2	SSTR2, GAST, DMD, PCSK1, TRH
2	doca32	10.1	CYP17A1, NR3C1, CYP21A2, CYP11A1, CYP11B2, HSD3BP4
3	acth 1-2432	10.0	CYP11A1, MC2R, SERPINA6, CYP17A1, CYP21A2, CRH
4	11beta-hydroxysteroid32	10.0	POMC, CRH, NR3C1, CYP21A2, CYP17A1, CYP11A1
5	metyrapone32 42 9 9	12.9	POMC, POR, CRH, NR3C1, SST, CYP21A2
6	3beta-hydroxysteroid32	9.8	POMC, POR, MC2R, STAR, NR5A1, CYP21A2
7	pge232	9.6	GAST, OXT, STAR, CRH, NR5A1, NR1H2
8	11 deoxycortisol32	9.6	CYP21A2, CYP17A1, CYP11B2, SERPINA6, REN, NR3C1
9	17-hydroxyprogesterone32 18	10.6	PRL, SHBG, CRH, CYP21A2, CYP17A1, CYP11A1
10	17beta-hydroxysteroid32	9.6	HSD3BP4, STAR, NR5A1, CYP21A2, S100A6, HSD3B2
11	gnrh32	9.4	GAL, POMC, STAR, SHBG, CRH, NR5A1
12	dehydroepiandrosterone sulfate32	9.2	SHBG, CRH, NR5A1, CYP21A2, CYP17A1, CYP11A1
13	progestin32	9.1	POMC, S100A6, PRL, OXT, STAR, TH
14	dopamine32 9 18 9	11.9	GAL, NPPA, OXT, TH, CRH, NR3C1
15	ketoconazole32 42 9 18 9	12.8	SHBG, CRH, NR3C1, NR1H2, SST, CYP27B1
16	spironolactone32 42 34 9 9	12.8	NR3C1, CYP21A2, CYP11B2, REN, CRH, SHBG
17	androstenedione32 18	9.7	CYP11A1, CYP11B2, HSD3BP4, HSD11B1, HSD3B2, MC2R
18	corticosterone32 18	9.7	GAST, BGLAP, SERPINA6, HSD11B1, CYP11B2, CYP11A1
19	creatinine32	8.6	TG, REN, VDR, ABCB7, SHBG, WT1
20	ribonucleic acid32	8.5	POMC, PRL, STAR, TG, WT1, CRH
21	glutamate32	8.5	CYP21A2, SST, CTLA4, NR1H2, TH, OXT
22	octreotide32 42 9 9	11.4	CHGA, INS, GAST, GAL, POMC, TRH
23	calcium32 9 18 9	11.3	CYP21A2, CYP11A1, CYP11B2, CYP27B1, REN, ABCB7
24	nifedipine32 9 9	10.2	ABCB1, CRH, SST, CYP17A1, CYP11A1, CYP2D6
25	estradiol32 9 18 9	11.2	GAL, POMC, PRL, OXT, STAR, ABCB7
26	mifepristone32 42 9 9	11.2	PRL, OXT, ABCB1, SHBG, CRH, NR3C1
27	dhea32	8.2	CYP17A1, CYP11A1, CYP11B2, HLA-B, HSD3BP4, HSD11B1
28	progesterone32 42 9 18 9	12.2	CRH, NR5A1, NR0B1, SSTR2, CYP21A2, CYP17A1
29	vitamin d32	8.1	GAST, VDR, POR, SHBG, WT1, CRH
30	prednisolone32 9 9	10.1	CYP21A2, NR3C1, SHBG, ABCB1, TG, POMC
31	cyproteroneacetate32	8.1	INS, F2, NR1H2, NR3C1, SHBG, SERPINA6
32	forskolin32 42 9 9	11.0	POMC, OXT, STAR, TH, ABCD1, ABCB1
33	glycerol32 9 18 9	11.0	CRH, GK, CD79A, INS, IL1RAPL1, HSD11B1
34	adenylate32	7.9	TG, MC2R, CHGA, VDR, SERPINA6, PCSK1
35	dihydrotestosterone32 9 18 9	10.8	NR3C1, NR1H2, CYP21A2, CYP17A1, CYP11A1, HSD3B2
36	lipid32	7.8	NR5A1, NR1H2, CTLA4, CYP27B1, CYP21A2, CYP17A1
37	norepinephrine32 9 18 9	10.5	S100A6, CHGA, REN, CD79A, TG, TH
38	thyroxine32 18	8.4	NR1H2, SST, CYP21A2, TPO, TRH, INS
39	steroid32	7.4	POMC, POR, PRL, OXT, STAR, SHBG
40	acth32	7.3	SSTR2, SST, CYP21A2, CYP17A1, CYP11A1, CYP11B2
41	epinephrine32 9 18 9	10.1	CYP21A2, DDC, F2, FCGR2A, INS, CD79A
42	hydrocortisone32 9 9	9.0	GAST, POMC, PRL, TG, ABCB1, SHBG
43	cholesterol32 9 18 9	10.0	CTLA4, CYP27B1, CYP21A2, CYP17A1, CYP11A1, CYP2D6
44	tyrosine32	6.5	GAST, PTPN22, TPO, TPH1, TRH, HLA-DRB1
45	alanine32	6.1	GAST, GAL, POMC, POR, STAR, TG
46	estrogen32	6.0	CYP21A2, SCARB1, BGLAP, VDR, SERPINA6, PCSK1
47	serine32	5.9	FCGR2A, NR3C1, NR1H2, CTLA4, CYP17A1, DMD
48	testosterone32 9 18 9	8.4	CYP11A1, VDR, SERPINA6, BGLAP, SCARB1, CYP2D6
49	arginine32	4.9	TG, ABCD1, SHBG, WT1, CRH, NR1H2
50	dexamethasone32 42 34 9 9	8.9	GAL, POMC, POR, PRL, STAR, TH

Cellular components related to addison's disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	perikaryon	GO:043204	10.2	CCR2, CYP11A1, CRHBP, TH
2	MHC class I protein complex	GO:042612	9.6	HLA-B, HLA-A, MICA, MICB
3	transport vesicle membrane	GO:030658	9.6	HLA-DRB1, HLA-DQB1, HLA-DQA1, CHGA
4	secretory granule	GO:030141	9.5	PCSK1, GAL, POMC, OXT, CRHBP, TRH
5	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
6	ER to Golgi transport vesicle membrane	GO:012507	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
7	cell surface	GO:009986	8.8	ABCB1, DMD, TPO, CCR5, IL1RAPL1, MICA
8	integral to plasma membrane	GO:005887	8.1	HLA-B, HLA-DQA1, HLA-DRB1, TPO, TNFRSF25, SSTR2
9	extracellular space	GO:005615	7.9	SST, CRH, CRHBP, OXT, POMC, F2
10	extracellular region	GO:005576	6.6	SHBG, TG, OXT, PRL, POMC, NPPA
11	plasma membrane	GO:005886	5.1	HLA-DQB1, HLA-DQA1, HLA-B, HLA-A, AIRE, GNRHR

Biological processes related to addison's disease according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	mineralocorticoid biosynthetic process	GO:006705	10.6	HSD3B2, CYP11B2, CYP21A2
2	steroid biosynthetic process	GO:006694	10.6	STAR, NR0B1, CYP17A1, HSD3B2
3	C21-steroid hormone biosynthetic process	GO:006700	10.6	CYP11B2, CYP11A1, STAR
4	glucocorticoid biosynthetic process	GO:006704	10.5	CRH, CYP21A2, CYP17A1, HSD11B1, HSD3B2
5	Leydig cell differentiation	GO:033327	10.4	NR0B1, CYP17A1, CYP11A1
6	adrenal gland development	GO:030325	10.4	WT1, CRH, NR5A1, NR3C1, NR0B1, CYP17A1
7	steroid metabolic process	GO:008202	10.3	HSD3B2, STAR, CYP27B1, CYP21A2, CYP17A1, CYP11A1
8	xenobiotic metabolic process	GO:006805	10.3	CYP27B1, CYP21A2, CYP17A1, CYP11A1, CYP2D6, CYP11B2
9	synaptic transmission, dopaminergic	GO:001963	10.2	TH, CRHBP, CRH
10	androgen biosynthetic process	GO:006702	10.0	CYP17A1, HSD3B2, SCARB1
11	transcription initiation from RNA polymerase II promoter	GO:006367	9.8	NPPA, NR5A1, NR3C1, NR1H2, NR0B1, ESRRB
12	T cell costimulation	GO:031295	9.7	CTLA4, HLA-DRB1, HLA-DQB1, HLA-DQA1, CD274, PDCD1
13	female pregnancy	GO:007565	9.5	NPPA, PRL, OXT, CRHBP, CRH
14	cell-cell signaling	GO:007267	9.3	POMC, NR5A1, SSTR2, SST, TRH, CCR5
15	interferon-gamma-mediated signaling pathway	GO:060333	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
16	response to drug	GO:042493	9.0	GAL, POR, ABCB1, SST, CYP17A1, CYP11A1
17	signal transduction	GO:007165	8.8	CRH, CRHBP, TG, OXT, POMC, GAST
18	cell surface receptor signaling pathway	GO:007166	8.5	CD274, CCR5, F2, TNFRSF25, SST, PRL
19	small molecule metabolic process	GO:044281	8.5	CYP11A1, CYP17A1, CYP21A2, CYP27B1, ABCB1, ABCD1
20	immune response	GO:006955	8.4	CTLA4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A

Molecular functions related to addison's disease according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:020037	10.3	CYP27B1, CYP21A2, CYP17A1, CYP11A1, CYP2D6, CYP11B2
2	electron carrier activity	GO:009055	10.3	POR, CYP27B1, CYP21A2, CYP17A1, CYP11A1, CYP2D6
3	iron ion binding	GO:005506	10.3	POR, TH, CYP27B1, CYP21A2, CYP17A1, CYP11A1
4	steroid hormone receptor activity	GO:003707	10.2	NR5A1, NR1H2, NR0B1, ESRRB, VDR
5	steroid binding	GO:005496	10.2	NR3C1, CYP21A2, ESRRB, SERPINA6
6	IgG binding	GO:019864	10.0	FCGR2A, FCGR3A, FCGR3B
7	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.0	NR5A1, NR1H2, NR0B1, ESRRB
8	MHC class II receptor activity	GO:032395	9.7	HLA-DQA1, HLA-DQB1, HLA-DRB1
9	hormone activity	GO:005179	8.9	INS, GAST, NPPA, POMC, PRL, TG
10	receptor binding	GO:005102	8.6	NPPA, POMC, CRH, HLA-B, HLA-A, F2