MCID: ADD001
MIFTS: 75

Addison's Disease malady

Endocrine diseases, Genetic diseases categories

Summaries for Addison's Disease

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 46OMIM, 32MalaCards
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MedlinePlus:33 Your adrenal glands are just above your kidneys. the outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. addison disease happens if the adrenal glands don't make enough of these hormones. a problem with your immune system usually causes addison disease. the immune system mistakenly attacks your own tissues, damaging your adrenal glands. other causes include infections and cancer. symptoms include weight loss muscle weakness fatigue that gets worse over time low blood pressure patchy or dark skin lab tests can confirm that you have addison disease. if you don't treat it, it can be fatal. you will need to take hormone pills for the rest of your life. if you have addison disease, you should carry an emergency id. it should say that you have the disease, list your medicines and say how much you need in an emergency. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Addison's Disease, also known as addison disease, is related to x-linked adrenal hypoplasia congenita and hypogonadism. An important gene associated with Addison's Disease is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2), and among its related pathways are Pregnenolone biosynthesis and Androgen biosynthesis. The drugs dexamethasone and fludrocortisone and the compounds estrogen and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, skin and testes, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:8 An adrenal cortical hypofunction that is characterized by insufficient steriod hormone production by the adrenal glands.

NIH Rare Diseases:42 Addison's disease is a condition that occurs when the adrenal glands do not produce enough of their hormones. this condition can be caused by damage to the adrenal glands, autoimmune conditions, and certain genetic conditions. some of the symptoms include changes in blood pressure, chronic diarrhea, darkening of the skin, paleness, extreme weakness, fatigue, nausea and vomiting, salt craving, and weight loss. treatment with replacement corticosteroids usually controls the symptoms. last updated: 4/28/2011

Description from OMIM:46 103230,240200

Aliases & Classifications for Addison's Disease

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
addison disease:
Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

addison's disease 8 42
addison disease 42 48 46 33 60
addisons disease 10 44
adrenocortical hypofunction, chronic primary congenital 8
addison disease, chronic adrenal insufficiency 8
addison's disease due to autoimmunity 60
primary adrenocortical insufficiency 8
adrenal cortical hypofunction 60
hypoadrenocorticism, familial 8
autoimmune addison's disease 48
hypoadrenocorticism familial 42
adrenal gland hypofunction 42
classic addison's disease 48
primary addison's disease 48
autoimmune adrenalitis 48
primary hypoadrenalism 8
adrenal hypoplasia 42
adrenal aplasia 42


External Ids:

Disease Ontology8 DOID:13774
NCIt39 C26689
MeSH34 D000224
MESH via Orphanet35 D000224
ICD10 via Orphanet26 E27.1
SNOMED-CT via Orphanet57 363732003, 76715008
UMLS via Orphanet61 C0001403, C0271737

Related Diseases for Addison's Disease

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17GeneCards, 18GeneDecks
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Diseases related to Addison's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1x-linked adrenal hypoplasia congenita30.9GK, STAR, NR0B1
2hypogonadism30.9NR0B1, CRH, GK, POMC
3triple-a syndrome30.3POMC, MC2R
4arthritis30.3PTPN22, CTLA4, POMC
5hypoadrenalism30.3CRH, POMC
6adrenoleukodystrophy30.2NR0B1, CYP21A2, REN, ABCD1
7hyperglycerolemia30.2GK2, NR0B1, GK
8duchenne muscular dystrophy30.2GK2, GK, NR0B1
9hypothyroidism30.2AIRE, POMC, CTLA4
10tuberculosis30.2CYP11A1, POMC
11achalasia30.2POMC, MC2R
12hypoparathyroidism30.2AIRE, CTLA4
13vitiligo30.2CTLA4, AIRE, PTPN22, POMC, DDC
14diabetes mellitus30.2POMC, CYP27B1, CTLA4, GK, REN, PTPN22
15adrenal carcinoma30.1POMC
16pseudohermaphroditism30.1CYP17A1, HSD3B2
17cushing's syndrome30.1CRH, POMC
18ovarian disease29.9STAR
19autoimmune polyendocrinopathy syndrome , type i, with or without reversible metaphyseal dysplasia29.9CYP11A1, CYP21A2, CYP17A1, AIRE, TPH1, DDC
20adrenal adenoma29.9CRH, POMC, CYP21A2, MC2R, REN, CYP11A1
21adenoma29.9CYP11A1, POMC, NR0B1, CRH, REN, CYP17A1
22metaphyseal dysplasia29.9NR0B1, AIRE
23hypospadias29.9CYP17A1, HSD3B2, CYP21A2
24leydig cell tumor29.9STAR, POMC, NR0B1, CYP11A1, CYP17A1, CYP21A2
25hyperandrogenism29.9CRH, HSD3B2, CYP17A1, POMC, CYP11A1, CYP21A2
26pituitary adenoma29.9NR0B1, CRH, MC2R, POMC
27adrenal cortical hypofunction10.7
28hypogonadotropism10.6
29intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies10.4
30pituitary hypoplasia10.4
31muscular dystrophy10.2
32waterhouse-friderichsen syndrome10.2
33polymyalgia rheumatica10.2
34congenital muscular dystrophy10.2
35hyperprolactinemia10.1
36chronic fatigue syndrome10.1
37myasthenia gravis10.1
38glucocorticoid deficiency, due to acth unresponsiveness10.1
39adrenal hypoplasia, congenital, with hypogonadotropic hypogonadism10.1
40inherited isolated adrenal insufficiency due to cyp11a1 deficiency10.1
41congenital adrenal hypoplasia of maternal cause10.1
42familial adrenal hypoplasia with absent pituitary luteinizing hormone10.1
43adrenocortical insufficiency, without ovarian defect10.1
44x-linked disease10.1
45autoimmune polyendocrinopathy type 210.1
46in situ carcinoma10.1
47image syndrome10.1
48isolated x-linked adrenal hypoplasia congenita10.1
49pulmonary tuberculosis10.1
50adrenocortical carcinoma10.0POMC

Graphical network of the top 20 diseases related to Addison's Disease:



Diseases related to addison's disease

Clinical Features for Addison's Disease

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46OMIM
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Clinical features from OMIM:

103230,240200

Clinical synopsis from OMIM:

103230

Drugs & Therapeutics for Addison's Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Addison's Disease

Drug clinical trials:

Search ClinicalTrials for Addison's Disease

Search NIH Clinical Center for Addison's Disease

Search CenterWatch for Addison's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Addison's Disease

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Anatomical Context for Addison's Disease

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32MalaCards
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MalaCards organs/tissues related to Addison's Disease:

32
Adrenal gland, Skin, Testes, Kidney, Thyroid, Bone, Pituitary, Cortex, T cells, Adrenal cortex, Liver, Heart, Prostate, B cells

Animal Models for Addison's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Addison's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.5GK, CYP27B1, CYP11A1, MC2R, ABCD1
2MP:000538610.3GK, CRH, CRHBP, DDC, AIRE, POMC
3MP:000538710.2CTLA4, CRH, DDC, AIRE, POMC, CYP27B1
4MP:000537610.2TPH1, GK, CTLA4, CRH, STAR, DDC
5MP:000537810.2DDC, STAR, CRHBP, CRH, GK, AIRE
6MP:000539710.2CTLA4, CRH, AIRE, POMC, CYP27B1, MC2R
7MP:000363110.2CRH, DDC, AIRE, POMC, CYP11A1, MC2R
8MP:000538910.2STAR, NR0B1, AIRE, CYP17A1, CYP27B1, CYP11A1
9MP:00107689.9GK, CTLA4, STAR, DDC, AIRE, POMC

Publications for Addison's Disease

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50PubMed
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Articles related to Addison's Disease:

(show top 50)    (show all 525)
idTitleAuthorsYear
1
Newly diagnosed type 1 diabetes presenting with hypoglycemia due to simultaneous presentation of Addison's disease. (24418108)
2014
2
Investigation of glucocorticoid receptor polymorphisms in relation to metabolic parameters in Addison's disease. (23239757)
2013
3
Screening for X-linked adrenoleukodystrophy among adult men with Addison's disease. (23346902)
2013
4
Drug prescription patterns in patients with Addison's disease: a Swedish population-based cohort study. (23543658)
2013
5
Genome-wide copy number variation (CNV) in patients with autoimmune Addison's disease. (21851588)
2011
6
Co-morbidities, management and clinical outcome of auto-immune Addison's disease. (20960111)
2010
7
Screening for associated autoimmune disorders in Polish patients with Addison's disease. (20960274)
2010
8
Adrenal crisis in treated Addison's disease: a predictable but under-managed event. (19776201)
2010
9
Addison's Disease Revisited in Poland: Year 2008 versus Year 1990. (21188237)
2010
10
Aspects of human disease. 37. Addison's disease (primary hypoadrenocorticism). (19810404)
2009
11
Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility. (19850680)
2009
12
Addison's disease and pregnancy: case report. (22439046)
2009
13
A patient with pseudo-Addison's disease and falsely elevated thyroxine due to interference in serum cortisol and free thyroxine immunoassays by two different mechanisms. (19225029)
2009
14
Immunology of Addison's disease and premature ovarian failure. (19328418)
2009
15
Addison's disease: a rare cause of hypertransaminasaemia. (18465237)
2008
16
AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS): partial gene deletions contribute to APS I. (18200029)
2008
17
Addison's disease due to adrenal tuberculosis: MRI features. (18180983)
2008
18
Premature mortality in patients with Addison's disease: a population-based study. (16968806)
2006
19
Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water Dogs. (16712648)
2006
20
Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. (14713279)
2004
21
Mineralocorticoid and glucocorticoid receptors and their differential effects on memory performance in people with Addison's disease. (15110920)
2004
22
A case of primary Addison's disease with hyperemesis gravidarum and successful pregnancy. (15036721)
2004
23
Focal segmental glomerular sclerosis in two patients with Addison's disease: any more than fortuitous development of glomerular disease? (12169875)
2002
24
Cortisol levels following therapy in tuberculous Addison's disease: results of long term follow up. (12502150)
2002
25
Quality of life in Addison's disease--the case for DHEA replacement. (12030905)
2002
26
Addison's disease should be diagnosed biochemically. (11464833)
2001
27
Screening for an AIRE-1 mutation in patients with Addison's disease, type 1 diabetes, Graves' disease and Hashimoto's thyroiditis as well as in APECED syndrome. (11298085)
2001
28
Fibromyalgia-Like Syndrome Secondary to Addison's Disease. (19078445)
2000
29
Abrupt onset of adrenal crisis during routine preoperative examination in a patient with unknown Addison's disease. (9915344)
1999
30
A case of non-Hodgkin's lymphoma following long-term corticosteroid therapy for Addison's disease. (9822970)
1998
31
Pseudotumor cerebri: a presenting manifestation of Addison's disease. (9415840)
1997
32
Similarity of symptoms in chronic fatigue syndrome and Addison's disease. (9466137)
1997
33
Duplex Doppler measurements of renal blood flow in a dog with Addison's disease. (9097245)
1997
34
Addison's disease and selective IgA deficiency in two coeliac patients. (9175216)
1997
35
Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. (8626850)
1996
36
Associated autoimmunity in Addison's disease. (7734032)
1995
37
Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease. (8227354)
1993
38
Recovery of adrenocortical function following treatment of tuberculous Addison's disease. (8290424)
1993
39
Association of Addison's disease with autoimmune disorders--a long-term observation of 180 patients. (1775423)
1991
40
X-ray microanalysis of ossified auricles in Addison's disease. (1901512)
1991
41
Addison's disease, hypertension, renal and hepatic microthrombosis in 'primary' antiphospholipid syndrome. (2068036)
1991
42
Delayed diagnosis of Addison's disease. (1859162)
1991
43
Addison's disease, malignant lymphoma and death from cerebral giant cell arteritis. (2794851)
1989
44
Pseudo-Addison's disease. Isolated corticotropin deficiency associated with hyporeninemic hypoaldosteronism. (3008682)
1986
45
Addison's disease initially diagnosed as bereavement and conversion disorder. (6507679)
1984
46
Familial idiopathic hypoparathyroidism with superficial moniliasis, pernicious anemia and Addison's disease. (5053557)
1972
47
Addison's disease, status asthmaticus, and shock. (4103970)
1971
48
Hyperkalemic quadriplegia in Addison's disease without hyperpigmentation. (5490979)
1970
49
Papilledema associated with increased intracranial pressure in Addison's disease. (14884806)
1952
50
Renal tuberculosis with Addison's disease. (14898599)
1951

Genetic Variations for Addison's Disease

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Expression for genes affiliated with Addison's Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Addison's Disease

Search GEO for disease gene expression data for Addison's Disease.

Pathways for genes affiliated with Addison's Disease

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Addison's Disease

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Addison's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CRHBP, TPH1
2acth 1-244410.8CYP11A1, CRH, CYP21A2, POMC, CYP17A1
3doca4410.8POMC, CYP17A1, CYP21A2, CYP11A1, REN
4Pregnenolone11 2411.8CYP11A1, CYP21A2, CYP17A1, HSD3B2
511 deoxycortisol4410.8CRH, POMC, CYP17A1, CYP21A2, REN
617-hydroxypregnenolone4410.7HSD3B2, POMC, CYP21A2, CYP17A1
7Corticotropin1110.7CRH, CYP27B1, MC2R, HSD3B2
8ketoconazole44 28 11 2413.7CYP11A1, CRH, POMC, CYP17A1, CYP27B1, CYP21A2
917-hydroxyprogesterone44 2411.7CYP11A1, REN, CYP17A1, POMC, CRH, HSD3B2
10cycloheximide4410.7STAR
113beta-hydroxysteroid4410.7CYP17A1, MC2R, CYP21A2, POMC, CYP11A1, STAR
12metyrapone59 44 1112.7CRH, POMC, CYP21A2, MC2R, TPH1
1321-deoxycortisol44 2411.7CYP17A1, POMC, CYP21A2
14aminoglutethimide44 1111.7MC2R, CYP21A2, POMC, CYP11A1
15dehydroepiandrosterone sulfate4410.7CYP11A1, CYP17A1, MC2R, CRH, HSD3B2, CYP21A2
16forskolin44 49 1112.7ABCD1, POMC, REN, CRH, STAR, CYP17A1
17corticosterone44 59 2412.7CYP11A1, CYP21A2, REN, CYP17A1, POMC, STAR
1811beta-hydroxysteroid4410.7HSD3B2, CRH, CYP17A1, CYP21A2, REN, MC2R
1917beta-hydroxysteroid4410.7HSD3B2, CYP11A1, CYP21A2, STAR, CYP17A1
20dhea4410.7CYP17A1, STAR, POMC, HSD3B2, CYP21A2, CYP11A1
21gnrh4410.7NR0B1, CRH, POMC, CYP11A1, CYP21A2, STAR
22norepinephrine44 11 2412.7DDC, POMC, GK, CYP21A2, TPH1
23catecholamine4410.7CYP21A2, POMC, DDC, CRH, REN, TPH1
24spironolactone49 44 59 28 1114.7CRH, REN, CYP21A2, POMC
25fludrocortisone44 28 1112.7POMC, CYP21A2, REN
26cortisol28 2411.7CYP21A2, HSD3B2, POMC
27androstenedione44 2411.7HSD3B2, CRH, STAR, POMC, CYP17A1, CYP21A2
28hydrocortisone44 2 59 1113.7CRHBP, POMC, CYP21A2, MC2R, REN, CRH
29acth4410.6CRHBP, CRH, HSD3B2, POMC, CYP21A2, CYP17A1
30chloramphenicol44 2 1112.6CYP21A2, DDC, CYP11A1, CRH, CYP17A1, CYP27B1
31ribonucleic acid4410.6MC2R, CYP11A1, CYP17A1, CRH, STAR, POMC
32estradiol44 11 2412.6CYP27B1, REN, CYP11A1, CYP21A2, CYP17A1, POMC
33cholesterol44 28 11 2413.6CYP11A1, HSD3B2, CTLA4, REN, STAR, NR0B1
34testosterone44 59 11 2413.6MC2R, CYP11A1, POMC, HSD3B2, CRH, STAR
35progesterone44 59 28 11 2414.6CYP21A2, STAR, HSD3B2, POMC, CYP17A1, CRHBP
36steroid4410.6HSD3B2, CTLA4, CRH, STAR, NR0B1, REN
375-hydroxytryptophan4410.6CRH, DDC, TPH1
38dexamethasone44 49 28 1113.6CYP17A1, MC2R, CYP11A1, CYP21A2, NR0B1, STAR
39cyclic amp44 2411.6CRH, NR0B1, CYP17A1, CYP27B1, CYP11A1, MC2R
40glycerol44 11 2412.6GK2, NR0B1, POMC, CRH, GK
41progestin4410.6CYP11A1, POMC, CYP17A1, STAR
42fenfluramine28 44 1112.6CRH, POMC, TPH1
43arginine4410.6POMC, PTPN22, TPH1, CYP21A2, REN, ABCD1
44homovanillic acid44 2411.5DDC, TPH1, CRH
45epinephrine44 11 2412.4CRH, DDC, POMC, CYP21A2, REN
465-hydroxyindoleacetic acid44 2411.4CRH, TPH1, DDC
47benzodiazepine4410.4GK, CRH, STAR
48cortisone44 2411.3CYP21A2, POMC, CRH
49tyrosine4410.3CTLA4, PTPN22, DDC, AIRE, CYP21A2, CYP27B1
50lipid4410.0CTLA4, STAR, CYP11A1, GK, CYP17A1, CYP21A2

GO Terms for genes affiliated with Addison's Disease

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16Gene Ontology
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Cellular components related to Addison's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00574110.4CYP27B1, GK, GK2
2perikaryonGO:04320410.4CYP11A1, CRHBP, CRH
3mitochondrial cristaGO:03006110.3CYP11A1, STAR
4varicosityGO:04319610.1CRH, CRHBP

Biological processes related to Addison's Disease according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1response to fungicideGO:06099210.8STAR, CYP17A1, CYP11A1
2dibenzo-p-dioxin metabolic processGO:01889410.8STAR, CYP17A1, CYP11A1
3biphenyl metabolic processGO:01887910.8STAR, CYP17A1, CYP11A1
4Leydig cell differentiationGO:03332710.8CYP11A1, CYP17A1, NR0B1
5sterol metabolic processGO:01612510.8CYP17A1, CYP21A2, CYP11A1
6fractalkine metabolic processGO:05075610.8STAR, CYP11A1
7phthalate metabolic processGO:01896310.8STAR, CYP17A1, CYP11A1
8phenol-containing compound metabolic processGO:01895810.8STAR, CYP17A1, CYP11A1
9glucocorticoid biosynthetic processGO:00670410.8HSD3B2, CRH, CYP17A1, CYP21A2
10cellular response to antibioticGO:07123610.8STAR, CYP17A1, CYP11A1
11steroid biosynthetic processGO:00669410.8HSD3B2, STAR, NR0B1, CYP17A1
12cellular response to cocaineGO:07131410.8CRH, CRHBP
13serotonin biosynthetic processGO:04242710.8TPH1, DDC
14adrenal gland developmentGO:03032510.8CYP17A1, NR0B1, CRH
15response to corticosterone stimulusGO:05141210.8CYP11A1, STAR, CRH
16response to insecticideGO:01708510.8CYP17A1, CYP11A1
17response to immobilization stressGO:03590210.8CRH, TPH1
18glycerol catabolic processGO:01956310.8GK2, GK
19xenobiotic metabolic processGO:00680510.8CYP17A1, CYP27B1, CYP21A2, CYP11A1
20steroid metabolic processGO:00820210.8CYP11A1, CYP21A2, CYP27B1, CYP17A1, STAR, HSD3B2
21testosterone biosynthetic processGO:06137010.8STAR, CYP11A1
22mineralocorticoid biosynthetic processGO:00670510.8HSD3B2, CYP21A2
23diterpenoid metabolic processGO:01610110.8CRH, STAR
24cellular response to cAMPGO:07132010.8CYP11A1, STAR, CRHBP
25indolalkylamine biosynthetic processGO:04621910.7DDC, TPH1
26cellular response to drugGO:03569010.7CRHBP, DDC, REN
27C21-steroid hormone biosynthetic processGO:00670010.7CYP11A1, STAR
28cellular response to alkaloidGO:07131210.7STAR, DDC
29progesterone biosynthetic processGO:00670110.7CYP11A1, STAR
30response to estrogen stimulusGO:04362710.7CYP27B1, STAR, CRH
31response to herbicideGO:00963510.7CYP17A1, STAR
32cellular response to follicle-stimulating hormone stimulusGO:07137210.7CYP11A1, STAR
33cellular response to lipopolysaccharideGO:07122210.7STAR, CYP17A1, CYP11A1
34cellular response to dexamethasone stimulusGO:07154910.7STAR, CRH
35estrogen biosynthetic processGO:00670310.6STAR, CYP11A1
36small molecule metabolic processGO:04428110.6HSD3B2, GK, STAR, DDC, CYP17A1, CYP27B1
37vitamin D metabolic processGO:04235910.6CYP11A1, CYP27B1
38male gonad developmentGO:00858410.6REN, NR0B1, STAR
39regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.6CRH, CRHBP
40androgen biosynthetic processGO:00670210.5HSD3B2, CYP17A1
41synaptic transmission, dopaminergicGO:00196310.5CRH, CRHBP
42glycerol metabolic processGO:00607110.4GK, GK2
43response to drugGO:04249310.4CRH, STAR, CYP17A1, CYP11A1
44hypothalamus developmentGO:02185410.3NR0B1, CRH
45cellular response to cadmium ionGO:07127610.1CYP11A1, STAR

Molecular functions related to Addison's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:00905510.4CYP11A1, CYP21A2, CYP27B1, CYP17A1
2iron ion bindingGO:00550610.4TPH1, CYP11A1, CYP21A2, CYP27B1, CYP17A1
3heme bindingGO:02003710.3CYP17A1, CYP27B1, CYP21A2, CYP11A1
4glycerol kinase activityGO:00437010.1GK, GK2

Products for genes affiliated with Addison's Disease

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Sources for Addison's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet