MCID: ADN016
MIFTS: 60

Adenocarcinoma malady

Summaries for Adenocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A carcinoma that has material basis in abnormally proliferating cells, derives from epithelial cells, which originate in glandular tissue.

MalaCards: Adenocarcinoma, also known as adenocarcinoma, no subtype, is related to lung adenocarcinoma and gastric adenocarcinoma. An important gene associated with Adenocarcinoma is MUC4 (mucin 4, cell surface associated), and among its related pathways are Endometrial cancer and Hepatitis C. The drug thiotepa and the compounds tyrosine and paraffin have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and colon, and related mouse phenotypes are digestive/alimentary and normal.

Wikipedia:63 Adenocarcinoma (adeno-, \"gland\" and karkin(o)-, \"cancerous\" and -oma, \"tumor\")... more...

Aliases & Classifications for Adenocarcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

adenocarcinoma 8 10 44 60
adenocarcinoma, no subtype 8
adenocarcinoma nos 8
adenocarcinomas 8


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Disease Ontology8 DOID:299
NCIt39 C2852
MeSH34 D000230

Related Diseases for Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Adenocarcinoma family:

Adenocarcinoma in Situ

Diseases related to Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 902)
idRelated DiseaseScoreTop Affiliating Genes
1lung adenocarcinoma31.9CTSB, KRAS, MUC4, BRAF
2gastric adenocarcinoma31.8MUC4, CDH3, KRAS, EPCAM
3pancreatitis31.7CTSB, KRAS
4colon adenocarcinoma31.7KRAS
5pancreatic ductal adenocarcinoma31.5CLDN18
6squamous cell carcinoma31.2MUC4, CDH3, CTSB, EPCAM, AXIN1, KRAS
7adenoma31.1BRAF, MUC4, CTSB, KRAS, CDH3
8lung cancer30.9EPCAM, MUC4, CTSB, KRAS
9pancreatic cancer30.7MUC4, KRAS, EPCAM, CDH3, BRAF, MTA1
10prostate cancer30.6KRAS, EPCAM, AXIN1, CTNND2, CTSB, CDH3
11colon cancer30.6KRAS, EPCAM, CTSB, BRAF
12hepatitis30.5KRAS
13endometrial carcinoma30.5BRAF, MUC4, CDH3, KRAS
14colorectal cancer30.5CTSB, KRAS, BRAF, EPCAM, MTA1
15breast cancer30.4CDH3, KRAS, EPCAM, MUC4, CTSB
16melanoma30.4BRAF, MUC4, CTSB, MTA1, CDH3, EPCAM
17cholangiocarcinoma30.4BRAF, KRAS, MUC4
18ovarian cancer30.3MTA1, CTSB, BRAF, EPCAM, KRAS
19cervical cancer30.3KRAS, BRAF, AXIN1
20lynch syndrome30.2KRAS, BRAF
21bronchiolo-alveolar adenocarcinoma30.2MUC4, KRAS
22non-small cell lung carcinoma30.1EPB41L3, MUC4, KRAS, BRAF
23stomach cancer30.1CDH3, KRAS, MUC4, BRAF, CTSB
24pituitary adenoma30.0CDH3
25prostate adenocarcinoma11.1
26prostatitis11.1
27esophagitis11.1
28endometrial adenocarcinoma11.1
29mucinous adenocarcinoma11.0
30papillary adenocarcinoma11.0
31clear cell adenocarcinoma10.9
32barrett's adenocarcinoma10.9
33cervical adenocarcinoma10.9
34cervicitis10.9
35adenocarcinoma in situ10.9
36breast adenocarcinoma10.9
37esophagus adenocarcinoma10.9
38barrett's esophagus10.8
39pancreas adenocarcinoma10.8
40bladder adenocarcinoma10.7
41ovary adenocarcinoma10.7
42gallbladder adenocarcinoma10.7
43signet ring cell adenocarcinoma10.7
44thyroiditis10.7
45ovarian clear cell adenocarcinoma10.6
46endocervicitis10.6
47lung squamous cell carcinoma10.6
48gastric cardia adenocarcinoma10.6
49gastroesophageal junction adenocarcinoma10.6
50papillary serous adenocarcinoma10.6

Graphical network of the top 20 diseases related to Adenocarcinoma:



Diseases related to adenocarcinoma

Clinical Features for Adenocarcinoma

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Drugs & Therapeutics for Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma

Search NIH Clinical Center for Adenocarcinoma

Search CenterWatch for Adenocarcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Adenocarcinoma

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Anatomical Context for Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Adenocarcinoma:

32
Lung, Prostate, Colon, Breast, Cervix, Pancreas, Lymph node, Ovary, Thyroid, Endothelial, Liver, Salivary gland, Bone, Skin, Brain, Appendix, T cells, Testes, Uterus, Small intestine, Testis, Kidney, Pituitary, Tongue, B cells, Bone marrow, Myeloid, Spinal cord, Thymus, Monocytes, Smooth muscle, Nk cells, Placenta, Whole blood, Pancreatic islet, Pineal, Spleen, Eye, Fetal lung, Heart, Tonsil, Skeletal muscle, Bronchial epithelium, Trachea, Adrenal gland, Retina

Animal Models for Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.9BRAF, CTSB, AXIN1, EPCAM, CLDN18, KRAS
2MP:000287311.8BRAF, CTHRC1, CTSB, MALAT1, AXIN1, EPB41L3

Publications for Adenocarcinoma

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50PubMed
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Articles related to Adenocarcinoma:

(show top 50)    (show all 11759)
idTitleAuthorsYear
1
Different responses of human pancreatic adenocarcinoma cell lines to oncolytic Newcastle disease virus infection. (24384773)
2014
2
CD44 promotes Kras-dependent lung adenocarcinoma. (23208496)
2013
3
Current strategies in the therapeutic approach for adenocarcinoma of the ampulla of Vater. (24146684)
2013
4
CHFR aberrant methylation involves a subset of human lung adenocarcinoma associated with poor clinical outcomes. (23415374)
2013
5
Lung adenocarcinoma presenting with diffuse multiloculated cystic lesions. (24126405)
2013
6
Pulmonary artery embolization for refractory hypoxemia caused by invasive mucinous adenocarcinoma. (23328554)
2013
7
Bulbourethral gland adenocarcinoma in a 25-year-old man without comorbidities: Radical resection of proximal urethrae with Mitrofanoff-type appendicovesicostomy. (24215360)
2013
8
Anticancer effects of cinnamic acid in lung adenocarcinoma cell line h1299-derived stem-like cells. (24063280)
2013
9
Identification of intravascular tumor microenvironment features predicting the recurrence of pathological stage I lung adenocarcinoma. (23786153)
2013
10
eEF1A2 protein expression correlates with lymph node metastasis and decreased survival in pancreatic ductal adenocarcinoma. (23165190)
2013
11
Expression of Wnt5a, APC, I^-catenin and their clinical significance in human colorectal adenocarcinoma]. (23159080)
2012
12
Ureteric stricture: an unusual presentation of metastatic prostate adenocarcinoma. (23031752)
2012
13
Irrelevance of microsatellite instability in the epidemiology of sporadic pancreatic ductal adenocarcinoma. (23029359)
2012
14
Infiltrative gastric adenocarcinoma in a chinchilla (Chinchilla lanigera). (22621945)
2012
15
Enhanced gemcitabine-mediated cell killing of human lung adenocarcinoma by vector-based RNA interference against PLK1. (23153503)
2012
16
APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression. (22262720)
2012
17
The bioactive potential of red raspberry (Rubus idaeus L.) leaves in exhibiting cytotoxic and cytoprotective activity on human laryngeal carcinoma and colon adenocarcinoma. (22082102)
2012
18
Circumferential location predicts the risk of high-grade dysplasia and early adenocarcinoma in short-segment Barrett's esophagus. (22381529)
2012
19
The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts. (21350005)
2011
20
Polymorphisms of transforming growth factor-I^1 associated with increased risk of gastric cardia adenocarcinoma in north China. (21205231)
2011
21
Interesting image. Utility of FDG metabolism to differentiate synchronous metastatic liver lesions from synchronous colon cancer: nonmucinous versus mucinous adenocarcinoma. (20026977)
2010
22
Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]. (20583607)
2010
23
Metastatic uterine adenocarcinoma and hepatic lipomatosis in a llama (Lama glama). (19286516)
2009
24
Dkk-3 expression in the tumor endothelium: a novel prognostic marker of pancreatic adenocarcinomas. (19493271)
2009
25
A novel role for the retinoic acid-catabolizing enzyme CYP26A1 in Barrett's associated adenocarcinoma. (18059332)
2008
26
Comparison of STAT3 with HIF-1alpha, Ob and ObR expressions in human endometrioid adenocarcinomas. (18579174)
2008
27
Oxaliplatin plus gemcitabine as a salvage schedule for hormone-refractory prostate adenocarcinoma. (18558585)
2008
28
Heterogeneity of epidermal growth factor receptor mutations within a mixed adenocarcinoma lung nodule. (17889960)
2008
29
Relationship between cytokine gene polymorphism and development of gastric adenocarcinoma]. (17672967)
2007
30
Adult thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with thyroid transcription factor-1 expression. (17967658)
2007
31
Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus. (16712734)
2006
32
Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk. (16800823)
2006
33
The expression of hepatocyte nuclear factor-4alpha, a developmental regulator of visceral endoderm, correlates with the intestinal phenotype of gastric adenocarcinomas. (17393984)
2006
34
Sigmoid colon adenocarcinoma: 9 years from diagnosis to treatment. (16358142)
2005
35
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. (16049285)
2005
36
Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus - correlation with proliferation and clinicopathological parameters. (12085261)
2002
37
Breast adenocarcinoma complicating Kallmann's syndrome. (11711277)
2001
38
Oncogene amplification and genetic heterogeneity in the metaplasia-dysplasia-adenocarcinoma sequence of Barrett esophagus]. (11894407)
2001
39
Loss of tissue transglutaminase as a biomarker for prostate adenocarcinoma. (10918174)
2000
40
Regulation of estrogen activity by sulfation in human Ishikawa endometrial adenocarcinoma cells. (10369411)
1999
41
Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display. (10477871)
1999
42
Cyclooxygenase-2 up-regulation after FLAP transfection in human adenocarcinoma cell line HT29 cl.19A. (9804170)
1998
43
The expression of waf-1, p53 and bcl-2 in prostatic adenocarcinoma. (9052469)
1997
44
Evaluation of cathepsin D immunostaining in colorectal adenocarcinoma. (9274788)
1997
45
Does any correlation exist between the Gleason classification system and the computer-assisted microscope analysis of Feulgen-stained nuclei features in human prostate adenocarcinoma? (9025992)
1996
46
Role of alpha v beta 5 and alpha v beta 6 integrin glycosylation in the adhesion of a colonic adenocarcinoma cell line (HT29-D4). (9173090)
1996
47
Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. (7743510)
1995
48
Urodynamics in the early stages of spinal cord compression from prostate adenocarcinoma. (1433641)
1992
49
Conservative surgery plus adjuvant therapy for vulvovaginal rhabdomyosarcoma, diethylstilbestrol clear cell adenocarcinoma of the vagina, and unilateral germ cell tumors of the ovary. (1316595)
1992
50
Coexisting adenocarcinoma and cystadenofibroma (malignant cystadenofibroma) of the ovary. (3983670)
1985

Genetic Variations for Adenocarcinoma

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Expression for genes affiliated with Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma

Search GEO for disease gene expression data for Adenocarcinoma.

Pathways for genes affiliated with Adenocarcinoma

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2KRAS, AXIN1, BRAF
211.2BRAF, CLDN18, KRAS
311.2KRAS, CLDN18, EPB41L3
4
Hide members
10.9KRAS, BRAF
510.9AXIN1, SUPT7L

Compounds for genes affiliated with Adenocarcinoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4412.1MTA1, KRAS, CDH3, BRAF, CTSB, MUC4
2paraffin4411.6BRAF, CTSB, CDH3, EPCAM, KRAS
3progesterone44 59 28 11 2415.3EPB41L3, CDH3, MUC4, MTA1, BRAF
4panitumumab44 49 1112.8BRAF, KRAS

GO Terms for genes affiliated with Adenocarcinoma

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Products for genes affiliated with Adenocarcinoma

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Sources for Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet