MCID: ADN016
MIFTS: 58

Adenocarcinoma malady

Cancer diseases category
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Summaries for Adenocarcinoma

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A carcinoma that has material basis in abnormally proliferating cells, derives from epithelial cells, which originate in glandular tissue.

MalaCards: Adenocarcinoma, also known as adenocarcinoma, no subtype, is related to lung adenocarcinoma and gastric adenocarcinoma. An important gene associated with Adenocarcinoma is EPCAM (epithelial cell adhesion molecule), and among its related pathways are Signalling to ERKs and G protein signaling K RAS regulation pathway. The drug thiotepa and the compounds panitumumab and regorafenib have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and colon, and related mouse phenotype normal.

Wikipedia:65 Adenocarcinoma (adeno-, \"gland\" and karkin(o)-, \"cancerous\" and -oma, \"tumor\") (/? more...

Aliases & Classifications for Adenocarcinoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenocarcinoma 8 10 45 62
adenocarcinoma, no subtype 8
adenocarcinoma nos 8
adenocarcinomas 8


External Ids:

Disease Ontology8 DOID:299
MeSH35 D000230
NCIt40 C2852

Related Diseases for Adenocarcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Adenocarcinoma family:

Adenocarcinoma in Situ

Diseases related to Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 893)
idRelated DiseaseScoreTop Affiliating Genes
1lung adenocarcinoma32.1CTSB, KRAS, MUC4, BRAF
2gastric adenocarcinoma31.9KRAS, MUC4, EPCAM
3colon adenocarcinoma31.8KRAS
4adenoma31.3BRAF, MUC4, KRAS, CTSB
5lung cancer31.0CTSB, KRAS, MUC4, EPCAM
6melanoma30.6BRAF, EPCAM, MUC4, MTA1, KRAS, CTSB
7colorectal cancer30.6BRAF, EPCAM, MUC4, MTA1, KRAS, CTSB
8cholangiocarcinoma30.6KRAS, MUC4, BRAF
9pancreatic cancer30.6EPCAM, MUC4, KRAS
10colon cancer30.5CTSB, KRAS, EPCAM, BRAF
11ovarian cancer30.5BRAF, EPCAM, MTA1, KRAS, CTSB
12cystadenoma30.5KRAS, BRAF
13breast cancer30.5EPCAM, MUC4, KRAS, CTSB
14endometrial carcinoma30.5BRAF, MUC4, KRAS
15lynch syndrome30.5BRAF, KRAS
16bronchiolo-alveolar adenocarcinoma30.4KRAS, MUC4
17barrett esophagus/esophageal adenocarcinoma30.3ASCC1, CTHRC1
18non-small cell lung carcinoma30.2BRAF, EPB41L3, MUC4, KRAS
19stomach cancer30.1BRAF, MUC4, KRAS, CTSB
20hepatitis b29.8CTSB, KRAS, MTA1
21pancreatitis11.2
22prostatitis11.2
23prostate adenocarcinoma11.1
24esophagitis11.1
25endometrial adenocarcinoma11.1
26pancreatic ductal adenocarcinoma11.1
27mucinous adenocarcinoma11.0
28colorectal adenocarcinoma11.0
29clear cell adenocarcinoma11.0
30cervicitis11.0
31papillary adenocarcinoma10.9
32cervical adenocarcinoma10.9
33adenocarcinoma in situ10.9
34breast adenocarcinoma10.9
35barrett's esophagus10.8
36polymorphous low-grade adenocarcinoma10.8
37small bowel adenocarcinoma10.7
38thyroiditis10.7
39barrett's adenocarcinoma10.7
40endocervicitis10.7
41endotheliitis10.7
42ovarian clear cell adenocarcinoma10.6
43gallbladder adenocarcinoma10.6
44signet ring cell adenocarcinoma10.6
45hypoxia10.6
46urachal adenocarcinoma10.6
47teratoma10.5
48vaginitis10.5
49peritonitis10.5
50gastric cardia adenocarcinoma10.5

Graphical network of the top 20 diseases related to Adenocarcinoma:



Diseases related to adenocarcinoma

Symptoms for Adenocarcinoma

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Drugs & Therapeutics for Adenocarcinoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma

Search NIH Clinical Center for Adenocarcinoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Adenocarcinoma

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Anatomical Context for Adenocarcinoma

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33MalaCards
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MalaCards organs/tissues related to Adenocarcinoma:

33
Lung, Prostate, Colon, Breast, Cervix, Pancreas, Lymph node, Ovary, Thyroid, Endothelial, Liver, Salivary gland, Bone, Brain, Appendix, T cells, Testes, Uterus, Small intestine, Testis, Skin, Kidney, Pituitary, Tongue, B cells, Bone marrow, Myeloid, Spinal cord, Monocytes, Smooth muscle, Thymus, Nk cells, Placenta, Whole blood, Pancreatic islet, Pineal, Spleen, Eye, Fetal lung, Heart, Tonsil, Skeletal muscle, Bronchial epithelium, Trachea, Adrenal gland, Retina

Animal Models for Adenocarcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.0CTSB, CTHRC1, KRAS, MALAT1, EPB41L3, BRAF

Publications for Adenocarcinoma

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52PubMed
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Articles related to Adenocarcinoma:

(show top 50)    (show all 11653)
idTitleAuthorsYear
1
Inhibition of the Hedgehog pathway induces autophagy in pancreatic ductal adenocarcinoma cells. (24297612)
2014
2
18F-FDG PET/CT in a case of malignant priapism secondary to metastasis from mucoid adenocarcinoma of the cecum. (23334147)
2013
3
Psf3 is a prognostic biomarker in lung adenocarcinoma. (23127337)
2013
4
Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. (23393166)
2013
5
The "drunken honeycomb" feature of pulmonary mucinous adenocarcinoma: a diagnostic pitfall of bronchial brushing cytology. (21563323)
2013
6
Is a policy of watch and wait after a complete response following neoadjuvant treatment for locally advanced rectal adenocarcinoma justified? Should we reset the limit? (24288010)
2013
7
Mucinous adenocarcinoma arising from diffuse serrated adenoma of the appendix which mimics appendicular abscess. (23012662)
2012
8
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? (22436573)
2012
9
ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas. (22348389)
2012
10
Metastatic mucinous adenocarcinoma of the orbit. (21281073)
2011
11
The relationship between EGFR gain and VHL loss in lung adenocarcinoma and poor patient survival. (21556796)
2011
12
Phorbol 12,13 dibutyrate behaves in a tumor-inhibitory manner in esophageal adenocarcinoma cell lines. (21595773)
2011
13
Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL- 1/4.1B). (21131357)
2011
14
Metastatic esophageal adenocarcinoma presenting as an external auditory canal mass. (20115997)
2010
15
Quantitative expression analysis and prognostic significance of L-DOPA decarboxylase in colorectal adenocarcinoma. (20424616)
2010
16
Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma. (18798225)
2009
17
Prognostic value of KRAS mutations and Ki-67 expression in stage I lung adenocarcinomas. (19162366)
2009
18
Postoperative adjuvant chemotherapy for node-positive cervical adenocarcinoma. (19396009)
2009
19
Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma. (19245848)
2009
20
Expression and localization of ATP binding cassette (ABC) family of drug transporters in gastric hepatoid adenocarcinomas. (18439156)
2008
21
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays. (17449965)
2007
22
Expression of heparanase and nuclear factor kappa B in pancreatic adenocarcinoma]. (17715045)
2007
23
A novel dendritic cell-based cancer vaccine produces promising results in a syngenic CC-36 murine colon adenocarcinoma model. (17275030)
2007
24
Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma. (17667920)
2007
25
High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. (17868414)
2007
26
Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma. (17639508)
2007
27
Endometrial adenocarcinoma and mucometra in a 6-year-old Alaska Malamute dog. (16519728)
2006
28
Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma. (16353209)
2006
29
Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. (15753363)
2005
30
Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. (15929754)
2005
31
Calcified metastatic mediastinal lymph nodes from mucinous breast adenocarcinoma. (14566424)
2004
32
A case of transitional cell carcinoma of the renal pelvis with adenocarcinoma producing CEA and CA19-9]. (15518131)
2004
33
Prognostic significance of the infiltrative pattern invasion in endometrioid adenocarcinoma of the endometrium. (12895227)
2003
34
Human colon adenocarcinoma in the SCID/CB6 radiation chimera is susceptible to adoptive transfer of allogeneic human peripheral blood mononuclear cells. (12590703)
2002
35
Mucinous adenocarcinoma of ectopic breast tissue of the vulva. (12296762)
2002
36
Maspin expression in human gastric adenocarcinoma. (12366809)
2002
37
Lectin histochemistry of resected adenocarcinoma of the lung: helix pomatia agglutinin binding is an independent prognostic factor. (11891197)
2002
38
Parathyroid hormone-related protein production by adenocarcinoma in Barrett's esophagus patient with dermatomyositis. (11478513)
2001
39
Endometrial adenocarcinoma: a primer for the generalist. (11766149)
2001
40
The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation. (11696421)
2001
41
Adenocarcinoma in situ with a small cell (endometrioid) pattern in cervical smears: a test of the distinction from benign mimics using specific criteria. (10536349)
1999
42
Functional heterogeneity of colonic adenocarcinoma mucins for inhibition of Entamoeba histolytica adherence to target cells. (9561779)
1998
43
p53, c-erbB-2 and nm23 expression have no prognostic significance in primary pulmonary adenocarcinoma. (9196297)
1997
44
Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-2,p53, clinico-pathological variables and prognosis in colorectal adenocarcinoma. (8600060)
1996
45
Sorting of heparan sulfate proteoglycan into matrix compartments of prostate adenocarcinoma cells. (7830405)
1995
46
Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction. (7924810)
1994
47
Improved prediction of survival in advanced adenocarcinoma of the ovary by immunocytochemical analysis and the composition adjusted receptor level of the estrogen receptor. (8221656)
1993
48
Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb. (2032228)
1991
49
Serous papillary adenocarcinoma of the endometrium. Analysis of proto-oncogene amplification, flow cytometry, estrogen and progesterone receptors, and immunohistochemistry. (1690076)
1990
50
Small bowel adenocarcinoma and Crohn's disease. (3818257)
1986

Variations for Adenocarcinoma

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Expression for genes affiliated with Adenocarcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma

Search GEO for disease gene expression data for Adenocarcinoma.

Compounds for genes affiliated with Adenocarcinoma

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45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Adenocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1panitumumab45 51 1112.6KRAS, BRAF
2regorafenib51 1111.4KRAS, BRAF
3paraffin4510.4CTSB, BRAF, EPCAM, KRAS
4o6-methylguanine4510.4BRAF, KRAS
5valine4510.4BRAF, KRAS, CTSB
6crcs4510.3KRAS, BRAF
7estrogen4510.3CTSB, MUC4, KRAS, MTA1, BRAF
8retinoic acid45 2411.3KRAS, FGFBP1, CTSB, BRAF, MUC4
9cetuximab45 51 1112.2BRAF, KRAS
10progesterone45 29 61 24 1114.1MTA1, MUC4, EPB41L3, BRAF
115fluorouracil459.9CTSB, KRAS, EPCAM

GO Terms for genes affiliated with Adenocarcinoma

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16Gene Ontology
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Molecular functions related to Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.6FGFBP1, SUPT7L, BRAF, EPCAM, EPB41L3, CHMP2A

Products for genes affiliated with Adenocarcinoma

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Sources for Adenocarcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet