MCID: ADN016
MIFTS: 60

Adenocarcinoma malady

Summaries for Adenocarcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A carcinoma that has material basis in abnormally proliferating cells, derives from epithelial cells, which originate in glandular tissue.

MalaCards: Adenocarcinoma, also known as adenocarcinoma, no subtype, is related to adenoma and squamous cell carcinoma. An important gene associated with Adenocarcinoma is MUC4 (mucin 4, cell surface associated), and among its related pathways are Endometrial cancer and Hepatitis C. The drug thiotepa and the compounds tyrosine and paraffin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are digestive/alimentary and normal.

Wikipedia:64 Adenocarcinoma (adeno-, \"gland\" + carcin(o)-, \"cancerous\" + -oma, \"tumor\")... more...

Aliases & Classifications for Adenocarcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

adenocarcinoma 8 10 45 61
adenocarcinoma, no subtype 8
adenocarcinoma nos 8
adenocarcinomas 8


External Ids:

Disease Ontology8 DOID:299
NCIt40 C2852
MeSH35 D000230

Related Diseases for Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Adenocarcinoma family:

adenocarcinoma in situ

Diseases related to Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 795)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.3KRAS, CDH3, MUC4, CTSB, BRAF
2squamous cell carcinoma31.2CTSB, MTA1, MUC4, CDH3, AXIN1, EPCAM
3colorectal cancer30.5BRAF, CTSB, MTA1, EPCAM, KRAS
4bronchiolo-alveolar adenocarcinoma30.2KRAS, MUC4
5stomach cancer30.1BRAF, CTSB, MUC4, CDH3, KRAS
6mucinous adenocarcinoma11.0
7clear cell adenocarcinoma11.0
8breast adenocarcinoma10.9
9barrett's adenocarcinoma10.8
10bladder adenocarcinoma10.8
11barrett esophagus/esophageal adenocarcinoma10.8
12small bowel adenocarcinoma10.7
13signet ring cell adenocarcinoma10.7
14adenocarcinoma in situ10.7
15gastric cardia adenocarcinoma10.7
16barrett's esophagus10.7
17ovarian clear cell adenocarcinoma10.7
18urethra adenocarcinoma10.6
19urachal adenocarcinoma10.6
20papillary serous adenocarcinoma10.6
21gastroesophageal junction adenocarcinoma10.6
22hypoxia10.6
23appendix adenocarcinoma10.5
24teratoma10.5
25neuroendocrine carcinoma10.5
26adenosquamous carcinoma10.5
27large cell carcinoma10.5
28apocrine adenocarcinoma10.5
29urethra clear cell adenocarcinoma10.5
30tubular adenocarcinoma10.5
31periampullary adenocarcinoma10.5
32colon mucinous adenocarcinoma10.5
33esophageal squamous cell carcinoma10.5
34small cell carcinoma10.5
35renal pelvis adenocarcinoma10.5
36bile duct adenocarcinoma10.5
37h. pylori infection10.5
38ovarian mucinous adenocarcinoma10.5
39crohn's disease10.4
40papillary carcinoma10.4
41lung papillary adenocarcinoma10.4
42aggressive digital papillary adenocarcinoma10.4
43gastric squamous cell carcinoma10.4
44vulva adenocarcinoma10.4
45gastric lymphoma10.4
46gastric signet ring cell adenocarcinoma10.4
47adenoid cystic carcinoma10.4
48bladder signet ring cell adenocarcinoma10.4
49peutz-jeghers syndrome10.4
50peutz–jeghers syndrome10.4

Graphical network of the top 20 diseases related to Adenocarcinoma:



Diseases related to adenocarcinoma

Clinical Features for Adenocarcinoma

Drugs & Therapeutics for Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma

Search NIH Clinical Center for Adenocarcinoma

Search CenterWatch for Adenocarcinoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Adenocarcinoma

Anatomical Context for Adenocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Adenocarcinoma:

33
Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Brain, Retina, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Uterus, Placenta, Prostate, Testis, Cervix, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Atrioventricular node, Tongue, Fetal liver, Fetal lung, Trachea, Bronchial epithelium, Appendix, Fetal thyroid, Pancreatic islet, Pineal, Pituitary, Uterus corpus, Testis germ, Testis leydig

Animal Models for Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.9BRAF, CTSB, AXIN1, EPCAM, CLDN18, KRAS
2MP:000287311.8BRAF, CTHRC1, CTSB, MALAT1, AXIN1, EPB41L3

Publications for Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Adenocarcinoma:

(show top 50)    (show all 11770)
idTitleAuthorsYear
1
Diffusion-weighted imaging and positron emission tomography in various cytological subtypes of primary lung adenocarcinoma. (23849098)
2013
2
Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma. (22864623)
2013
3
Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study. (23137018)
2013
4
Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression. (23566884)
2013
5
Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma. (22670171)
2012
6
Role of the ABCE1 gene in human lung adenocarcinoma. (22267055)
2012
7
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. (21892161)
2011
8
Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis. (22130369)
2011
9
Polymorphous low grade adenocarcinoma: literature review and report of lower lip lesion with suspected lung metastasis. (22379323)
2011
10
Transforming growth factor-I^1 29T>C genetic polymorphism is associated with lymph node metastasis in patients with adenocarcinoma of the lung. (20506050)
2010
11
Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response. (19088045)
2008
12
Contrast enhanced 4D-CT imaging for target volume definition in pancreatic ductal adenocarcinoma. (18486253)
2008
13
Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro. (17943720)
2008
14
Effects of castration on the development of prostate adenocarcinoma from its precursor HGPIN and on the occurrence of androgen-independent, poorly differentiated carcinoma in TRAMP mice. (18379588)
2008
15
Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatin. (16297858)
2006
16
Familial Barrett's adenocarcinoma. (16542304)
2006
17
Very early stage adenocarcinoma arising from adenomyosis in the uterus. (17175497)
2006
18
No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. (16702391)
2006
19
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. (17114585)
2006
20
A case of osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: histopathological, immunohistochemical, ultrastructural and molecular biological studies. (15953882)
2005
21
Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma. (15680394)
2005
22
Effects of phorbol dibutyrate on cell proliferation, apoptosis, and tumor necrosis factor-alpha expression in human endometrial adenocarcinoma cells. (15979550)
2005
23
Prevalence of human papillomavirus DNA in various histological subtypes of cervical adenocarcinoma: a population-based study. (15502807)
2005
24
Effects of hypoxia on expression of P-gp and mutltidrug resistance protein in human lung adenocarcinoma A549 cell line. (16201271)
2005
25
Polymorphous low grade adenocarcinoma of the parotid gland. Cytological, histological and immunohistochemical features and review of the literature. (15168873)
2004
26
In vivo efficacy of folate-targeted lipid-protamine-DNA (LPD-PEG-Folate) complexes in an immunocompetent syngeneic model for breast adenocarcinoma. (14671672)
2004
27
Antiproliferative effects of interferon-alphaCon1 on ovarian clear cell adenocarcinoma in vitro and in vivo. (15534119)
2004
28
Prognostic impact of survivin, cyclin D1, integrin beta1, and VEGF in patients with small adenocarcinoma of stage I lung cancer. (15289739)
2004
29
A novel cell line and xenograft model of ampulla of Vater adenocarcinoma. (14677066)
2004
30
Conservative treatment may be beneficial for young women with atypical endometrial hyperplasia or endometrial adenocarcinoma. (14667859)
2003
31
Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells. (12171903)
2002
32
Susceptibility to gastric cardia adenocarcinoma and genetic polymorphisms in methylenetetrahydrofolate reductase in an at-risk Chinese population. (12433726)
2002
33
Adenocarcinoma on horseshoe kidney studied with computed tomography. (12636110)
2002
34
Immunohistochemical analysis of nuclear versus cytoplasmic staining of WT1 in malignant mesotheliomas and primary pulmonary adenocarcinomas. (11570906)
2001
35
Coexpression of vascular endothelial growth factor and its receptor KDR on gastric adenocarcinoma MGC803 cell line and stimulation of exogenous VEGF(165) to MGC803 cells. (18763120)
2000
36
Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. (10632746)
2000
37
Apoptosis in relation to proliferating cell nuclear antigen and Dukes' stage in colorectal adenocarcinoma. (10375593)
1999
38
Modulation of E-cadherin expression in TPA-induced cell motility: well-differentiated human adenocarcinoma cells move as coherent sheets associated with phosphorylation of E-cadherin-catenin complex. (9010457)
1997
39
Are there any arguments against hormone replacement therapy after treatment of ovarian adenocarcinoma?]. (9435801)
1997
40
Targeting immunotherapy using the avidin-biotin system for a human colon adenocarcinoma in vitro. (9027669)
1997
41
Bilateral panuveitis in a patient with colonic adenocarcinoma and Streptococcus milleri liver abscesses. (7556752)
1995
42
Acetylcholine, ATP, bombesin, and cholecystokinin stimulate 125I efflux from a human pancreatic adenocarcinoma cell line (BxPC-3). (7528918)
1994
43
Use of percutaneous transperineal 198Au seeds to treat recurrent prostate adenocarcinoma after failure of definitive radiotherapy. (8259342)
1993
44
Semiquantitative immunohistochemical studies of blood group antigen A, B, H, Le(a), Le(b) structures and Ii backbone chains in the normal human cervix and in cervical adenocarcinoma. (8473202)
1993
45
Two cases of mucinous adenocarcinoma of the prostate]. (1326881)
1992
46
A case of mucinous adenocarcinoma of the prostate]. (1690826)
1990
47
New monoclonal antibody, 1C5, reactive with human cervical adenocarcinoma of the uterus, with immunodiagnostic potential. (3052807)
1988
48
Gallbladder adenocarcinoma: the prognostic significance of histologic grade. (3807370)
1987
49
Phase II trial of spirogermanium in breast adenocarcinoma: a Cancer and Leukemia Group B Study. (7105058)
1982
50
Mucinous adenocarcinoma of the bovine ovary. (4293833)
1967

Genetic Variations for Adenocarcinoma

Expression for genes affiliated with Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma

Search GEO for disease gene expression data for Adenocarcinoma.

Pathways for genes affiliated with Adenocarcinoma

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2KRAS, AXIN1, BRAF
211.2BRAF, CLDN18, KRAS
311.2KRAS, CLDN18, EPB41L3
4
Hide members
10.9KRAS, BRAF
510.9AXIN1, SUPT7L

Compounds for genes affiliated with Adenocarcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Adenocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tyrosine4512.1MTA1, KRAS, CDH3, BRAF, CTSB, MUC4
2paraffin4511.6BRAF, CTSB, CDH3, EPCAM, KRAS
3progesterone45 60 29 11 2415.3EPB41L3, CDH3, MUC4, MTA1, BRAF
4panitumumab45 50 1112.8BRAF, KRAS

GO Terms for genes affiliated with Adenocarcinoma

Products for genes affiliated with Adenocarcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet