MCID: ADN012
MIFTS: 45

Adenocarcinoma in Situ

Categories: Cancer diseases

Aliases & Classifications for Adenocarcinoma in Situ

MalaCards integrated aliases for Adenocarcinoma in Situ:

Name: Adenocarcinoma in Situ 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4943
MeSH 41 D065311
NCIt 46 C4123
SNOMED-CT 64 51642000
UMLS 69 C0334276

Summaries for Adenocarcinoma in Situ

MalaCards based summary : Adenocarcinoma in Situ is related to endometrial adenocarcinoma and cervical adenocarcinoma. An important gene associated with Adenocarcinoma in Situ is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Cervarix and Gardasil have been mentioned in the context of this disorder. Affiliated tissues include cervix, lung and testes, and related phenotypes are cellular and embryo

Related Diseases for Adenocarcinoma in Situ

Diseases in the Adenocarcinoma family:

Adenocarcinoma in Situ

Diseases related to Adenocarcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 endometrial adenocarcinoma 30.0 CDKN2A KRAS KRT7
2 cervical adenocarcinoma 30.0 CDKN1A CDKN2A CDX2 KRT20 KRT7
3 endometrial mucinous adenocarcinoma 29.9 CDKN2A PAX2
4 villous adenoma 29.7 CDX2 KRAS KRT20
5 cystic teratoma 29.7 CDX2 KRT20 KRT7
6 papillary carcinoma 29.6 KRT20 KRT7 PAX8
7 teratoma 29.6 CDX2 KRT20 KRT7
8 endocervical adenocarcinoma 29.5 CDKN2A CDX2 KRT20 KRT7 PAX2 PAX8
9 mucinous adenocarcinoma 29.5 CDKN2A CDX2 KRAS KRT20 KRT7
10 colon adenocarcinoma 29.4 CDKN1A KRAS KRT20
11 in situ pulmonary adenocarcinoma 11.1
12 adenocarcinoma 10.8
13 inverted transitional papilloma 10.5 CDKN2A KRT7
14 cervicitis 10.5
15 adenoid basal cell carcinoma 10.4 CDKN2A KRT7
16 endosalpingiosis 10.4 KRT7 PAX8
17 bladder carcinoma in situ 10.4 CDKN2A KRT7
18 cystic basal cell carcinoma 10.4 KRT20 KRT7
19 mucinous adenofibroma 10.4 CDX2 KRT7
20 lung acinar adenocarcinoma 10.4 KRT20 KRT7
21 seminal vesicle adenocarcinoma 10.4 KRT20 KRT7
22 transverse colon cancer 10.4 KRT20 KRT7
23 ovarian large-cell neuroendocrine carcinoma 10.4 KRT20 KRT7
24 eyelid neoplasm 10.4 KRT20 KRT7
25 malignant syringoma 10.4 KRT20 KRT7
26 krukenberg carcinoma 10.4 KRT20 KRT7
27 epithelial predominant wilms' tumor 10.4 CDX2 KRT7
28 large intestine adenocarcinoma 10.4 KRT20 KRT7
29 linitis plastica 10.4 KRT20 KRT7
30 small cell carcinoma of the bladder 10.4 KRT20 KRT7
31 well-differentiated liposarcoma 10.4 CDKN2A KRT7
32 adenoid squamous cell carcinoma 10.4 KRT20 KRT7
33 rete testis adenoma 10.4 PAX2 PAX8
34 eccrine sweat gland neoplasm 10.4 KRT20 KRT7
35 childhood endodermal sinus tumor 10.4 PAX2 PAX8
36 bile duct cystadenocarcinoma 10.4 KRT20 KRT7
37 intratubular embryonal carcinoma 10.4 KRT20 KRT7
38 mucinous ovarian cystadenoma 10.4 CDX2 KRT7
39 renal adenoma 10.4 KRT7 PAX2
40 meibomian cyst 10.4 KRT20 KRT7
41 bladder lymphoma 10.4 KRT20 KRT7
42 papillary serous adenocarcinoma 10.4 KRT20 KRT7
43 renal pelvis carcinoma 10.4 KRT20 KRT7
44 ovary adenocarcinoma 10.4 KRAS KRT7
45 proliferative verrucous leukoplakia 10.4 CDKN2A MCM2
46 medulloepithelioma 10.3 KRT20 KRT7
47 endocervicitis 10.3
48 esophagus adenocarcinoma 10.3 CDKN2A CDX2
49 urethral diverticulum 10.3 KRT7 PAX8
50 paget disease, extramammary 10.3 KRT20 KRT7

Graphical network of the top 20 diseases related to Adenocarcinoma in Situ:



Diseases related to Adenocarcinoma in Situ

Symptoms & Phenotypes for Adenocarcinoma in Situ

MGI Mouse Phenotypes related to Adenocarcinoma in Situ:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CDX2 KRAS KRT7 MCM2 PAX2 CDKN1A
2 embryo MP:0005380 9.87 KRAS MCM2 PAX2 CDKN1A PAX8 CDKN2A
3 endocrine/exocrine gland MP:0005379 9.8 KRAS MCM2 PAX2 CDKN1A CDKN2A PAX8
4 neoplasm MP:0002006 9.55 CDX2 KRAS MCM2 CDKN1A CDKN2A
5 pigmentation MP:0001186 9.26 KRAS MCM2 PAX2 CDKN2A
6 renal/urinary system MP:0005367 9.1 CLDN10 KRAS KRT7 PAX2 CDKN1A PAX8

Drugs & Therapeutics for Adenocarcinoma in Situ

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Cervarix 17 45 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009
2
Gardasil 17 45 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006

Drugs for Adenocarcinoma in Situ (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
2
Metformin Approved Phase 2 657-24-9 4091 14219
3
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
4
Testosterone Approved, Investigational Phase 1, Phase 2 58-22-0 6013
5 Hypoglycemic Agents Phase 2
6 Alkylating Agents Phase 1, Phase 2
7 Androgens Phase 1, Phase 2
8 Antirheumatic Agents Phase 1, Phase 2
9 Hormone Antagonists Phase 1, Phase 2
10 Hormones Phase 1, Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
12 Immunosuppressive Agents Phase 1, Phase 2
13
Proflavine Approved 92-62-6 7099
14 Anti-Infective Agents
15 Anti-Infective Agents, Local
16 Pharmaceutical Solutions

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 V501 Safety and Efficacy Study in Japanese Women Aged 16 to 26 Years (V501-110) Completed NCT01544478 Phase 4
2 Study of Ablation for the Pulmonary Focal Pure Ground Glass Opacity (pGGO) Unknown status NCT01429649 Phase 3
3 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Completed NCT00092521 Phase 3
4 Vaccine To Prevent Cervical Intraepithelial Neoplasia or Cervical Cancer in Younger Healthy Participants Completed NCT00128661 Phase 3
5 Comparison of cVATS Segmentectomy Versus Lobectomy for Lung Adenocarcinoma in Situ and With Microinvasion Not yet recruiting NCT02011997 Phase 3
6 Dose-Ranging Study of Quadrivalent Human Papillomavirus (HPV) (Types 6,11,16,18) L1 Virus-Like Particle (VLP) Vaccine (V501-007)(COMPLETED) Completed NCT00365716 Phase 2
7 Metformin With Neoadjuvant Chemoradiation to Improve Pathologic Responses in Rectal Cancer Recruiting NCT03053544 Phase 2 Metformin
8 A Neoadjuvant Study of Androgen Ablation Combined With Cyclophosphamide and GVAX Vaccine for Localized Prostate Cancer Active, not recruiting NCT01696877 Phase 1, Phase 2 degarelix acetate;Cyclophosphamide;GVAX
9 Randomized Controlled Trial of Human Papillomavirus Testing in Primary Cervical Cancer Screening Completed NCT00479375
10 Human Papillomavirus in Cervical Cancer and Pre-cancer in Switzerland: The CIN3+Plus Study Completed NCT02323997
11 Use of High-Resolution Microendoscopy (HRME) in Patients With Adenocarcinoma In-Situ (AIS) of the Cervix Recruiting NCT02206048 Proflavine
12 In the Era of the HPV Vaccine, What Are The Current HPV Subtypes Contributing to High Grade Cervical Dysplasia, Adenocarcinoma in Situ, and Early Cervical Cancer? Recruiting NCT02937155
13 A Clinical Test for the Treatment of Multifocal Lung Cancers Using Genome Sequencing Recruiting NCT02705404
14 Treatment of Multifocal Lung Adenocarcinoma Recruiting NCT01946100
15 Long-term Follow-up of Broad Spectrum Human Papillomavirus (HPV) Vaccine Study in Women (V503-021) Active, not recruiting NCT02653118
16 Evaluation of Long-term HPV Vaccine Efficacy Enrolling by invitation NCT01393470
17 A Post Marketing Surveillance (PMS) Study to Monitor the Safety of GlaxoSmithKline (GSK) Biologicals' Human Papillomavirus (HPV) Vaccine in Female Chinese Subjects Not yet recruiting NCT03438006
18 Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC Not yet recruiting NCT03216551
19 Pilot Study In Vivo Confocal Microscopy Probe for Cervical Precancer Suspended NCT02574442

Search NIH Clinical Center for Adenocarcinoma in Situ

Cochrane evidence based reviews: adenocarcinoma in situ

Genetic Tests for Adenocarcinoma in Situ

Anatomical Context for Adenocarcinoma in Situ

MalaCards organs/tissues related to Adenocarcinoma in Situ:

38
Cervix, Lung, Testes, Prostate, Colon, Lymph Node, Ovary

Publications for Adenocarcinoma in Situ

Articles related to Adenocarcinoma in Situ:

(show top 50) (show all 268)
# Title Authors Year
1
A case of urachal villous adenoma with high grade dysplasia focally bordering on adenocarcinoma in situ. ( 29321972 )
2018
2
HRCT texture analysis for pure or part-solid ground-glass nodules: distinguishability of adenocarcinoma in situ or minimally invasive adenocarcinoma from invasive adenocarcinoma. ( 29273964 )
2018
3
Thoracoscopic total esophagogastrectomy with supercharged colon interposition for the treatment of esophageal adenocarcinoma in situs inversus. ( 29436979 )
2018
4
Targeted next-generation sequencing for analyzing the genetic alterations in atypical adenomatous hyperplasia and adenocarcinoma in situ. ( 28821955 )
2017
5
Risk of persistent or recurrent cervical neoplasia in patients with 'pure' adenocarcinoma-in-situ (AIS) or mixed AIS and high-grade cervical squamous neoplasia (cervical intra-epithelial neoplasia grades 2 and 3 (CIN 2/3)): a population-based study. ( 28678394 )
2017
6
Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis. ( 28125627 )
2017
7
Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins. ( 28181670 )
2017
8
Response to: Cutaneous papillary adenocarcinoma in situ. ( 28299799 )
2017
9
False-Negative Interpretation of Adenocarcinoma In Situ in the College of American Pathologists Gynecologic PAP Education Program. ( 28301226 )
2017
10
HPV-negative Gastric Type Adenocarcinoma In Situ of the Cervix: A Spectrum of Rare Lesions Exhibiting Gastric and Intestinal Differentiation. ( 28394803 )
2017
11
Human Papillomavirus-Associated Adenocarcinoma In Situ of the Vestibule. ( 28953132 )
2017
12
Adenocarcinoma In Situ Arising from Brunner's Gland Treated by Endoscopic Mucosal Resection. ( 28512587 )
2017
13
Two cases of adenocarcinoma in situ arising in lobular endocervical glandular hyperplasia indicating localization of mucin on the cluster surface as an early cytological finding of malignant transformation. ( 28449203 )
2017
14
Excisional treatment in women with cervical adenocarcinoma in situ (AIS): a prospective randomised controlled non-inferiority trial to compare AIS persistence/recurrence after loop electrosurgical excision procedure with cold knife cone biopsy: protocol for a pilot study. ( 28851799 )
2017
15
Cutaneous papillary adenocarcinoma in situ. ( 28164358 )
2017
16
Lung Adenocarcinoma Staging Using the 2011 IASLC/ATS/ERS Classification: A Pooled Analysis of Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma. ( 27137345 )
2016
17
Epidermal growth factor receptor mutations in adenocarcinoma in situ and minimally invasive adenocarcinoma detected using mutation-specific monoclonal antibodies. ( 27565930 )
2016
18
Risk of persistent and recurrent cervical neoplasia following incidentally detected adenocarcinoma in situ. ( 27908632 )
2016
19
Adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive pulmonary adenocarcinoma-analysis of interobserver agreement, survival, radiographic characteristics, and gross pathology in 296 nodules. ( 27067781 )
2016
20
Thin-section computed tomography-histopathologic comparisons of pulmonary focal interstitial fibrosis, atypical adenomatous hyperplasia, adenocarcinoma in situ, and minimally invasive adenocarcinoma with pure ground-glass opacity. ( 27666606 )
2016
21
Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung. ( 27597281 )
2016
22
Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists. ( 27174588 )
2016
23
Syringocystadenocarcinoma Papilliferum In Situ, a Variant of Cutaneous Adenocarcinoma In Situ: A Case Report With Literature Review. ( 27533073 )
2016
24
Case of anal adenocarcinoma in situ with pagetoid spread but without macroscopic abnormality in anal mucosa. ( 27666572 )
2016
25
Gastric-type adenocarcinoma in situ of uterine cervix: cytological and histopathological features of two cases. ( 27334141 )
2016
26
Diagnosis of lung adenocarcinoma in situ and minimally invasive adenocarcinoma from intraoperative frozen sections: an analysis of 136 cases. ( 27174927 )
2016
27
Performance of HPV DNA testing in the follow-up after treatment of high-grade cervical lesions, adenocarcinoma in situ (AIS) and microinvasive carcinoma. ( 25987897 )
2015
28
Endocervical adenocarcinoma in situ presenting in fundal endometrial polyp: the mother of all skip lesions. ( 25844546 )
2015
29
Laparoscopic Oophorectomy and Radical Lymph Node Dissection for a Recurrent Adenocarcinoma In Situ of the Cervix. ( 27678792 )
2015
30
Cytological variations and typical diagnostic features of endocervical adenocarcinoma in situ: A retrospective study of 74 cases. ( 25972909 )
2015
31
Conservative Treatment Seems the Best Choice in Adenocarcinoma In Situ of the Cervix Uteri. ( 25943864 )
2015
32
Comparison of cold knife cone biopsy and loop electrosurgical excision procedure in the management of cervical adenocarcinoma in situ: What is the gold standard? ( 25769659 )
2015
33
The effect of coexisting squamous cell lesions on prognosis in patients with cervical adenocarcinoma in situ. ( 25956340 )
2015
34
Cytological Diagnoses of Adenocarcinoma in situ of the Cervix: Common Misdiagnoses. ( 25766846 )
2015
35
Coexistence of mature cystic teratoma and adenocarcinoma in situ within atypical proliferative mucinous tumour of ovary--a case report of 35-year-old woman. ( 26050362 )
2015
36
Extrafascial Hysterectomy Without Preoperative Conization is Unacceptable in Patients With Adenocarcinoma in Situ Diagnosed by Cervical Punch Biopsy or Endocervical Curettage. ( 27679125 )
2015
37
Pulmonary adenocarcinoma in situ: analyses of a large series with reference to smoking, driver mutations, and receptor tyrosine kinase pathway activation. ( 25970685 )
2015
38
Prognosis and status of lymph node involvement in patients with adenocarcinoma in situ and minimally invasive adenocarcinoma-a systematic literature review and pooled-data analysis. ( 26716039 )
2015
39
Secondhand Tobacco Smoke Exposure and Lung Adenocarcinoma In Situ/Minimally Invasive Adenocarcinoma (AIS/MIA). ( 26503035 )
2015
40
Can adenocarcinoma in situ of the uterine cervix be treated safely by conisation in combination with endocervical curettage? ( 25556275 )
2014
41
Management of Adenocarcinoma In Situ of the Uterine Cervix: A Comparison of Loop Electrosurgical Excision Procedure and Cold Knife Conization. ( 25089550 )
2014
42
A Case of HPV-negative Intestinal-type Endocervical Adenocarcinoma In Situ With Coexisting Multifocal Intestinal and Gastric Metaplasia. ( 24418863 )
2014
43
A report of adenocarcinoma in situ and congenital pulmonary airway malformation in a three-day-old infant with a review of the literature. ( 25341604 )
2014
44
Prognostic significance of adenocarcinoma in situ, minimally invasive adenocarcinoma, and nonmucinous lepidic predominant invasive adenocarcinoma of the lung in patients with stage I disease. ( 24472852 )
2014
45
Value of endocervical margin and high-risk human papillomavirus status after conization for high-grade cervical intraepithelial neoplasia, adenocarcinoma in situ, and microinvasive carcinoma of the uterine cervix. ( 25284039 )
2014
46
Diagnosis of metachronous multiple lung adenocarcinoma at the cut-end by epidermal growth factor receptor mutation status discordance 4A years after sublobar resection for adenocarcinoma in situ: report of a case. ( 25377270 )
2014
47
Genomic alterations in pulmonary adenocarcinoma in situ in an adolescent patient. ( 24678688 )
2014
48
Papillary adenocarcinoma in situ of the skin: report of four cases. ( 24855569 )
2014
49
Pathogenesis of combined high-grade squamous intraepithelial lesion and adenocarcinoma in situ of the uterine cervix: human papillomavirus genotype and methylation status and immunohistochemical study. ( 25612672 )
2014
50
Clinical outcomes of patients with adenocarcinoma in situ of the cervix treated by conization. ( 25556268 )
2014

Variations for Adenocarcinoma in Situ

Expression for Adenocarcinoma in Situ

Search GEO for disease gene expression data for Adenocarcinoma in Situ.

Pathways for Adenocarcinoma in Situ

GO Terms for Adenocarcinoma in Situ

Cellular components related to Adenocarcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleolus GO:0005730 9.02 CDKN1A CDKN2A MCM2 PAX2 TOP2A

Biological processes related to Adenocarcinoma in Situ according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 G1/S transition of mitotic cell cycle GO:0000082 9.72 CDKN1A CDKN2A MCM2
2 Ras protein signal transduction GO:0007265 9.7 CDKN1A CDKN2A KRAS
3 cochlea development GO:0090102 9.62 MCM2 PAX2
4 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.62 CDKN1A CDKN2A
5 cellular senescence GO:0090398 9.61 CDKN1A CDKN2A
6 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 9.61 CLDN1 CLDN10
7 negative regulation of phosphorylation GO:0042326 9.6 CDKN1A CDKN2A
8 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.59 PAX2 PAX8
9 urogenital system development GO:0001655 9.58 PAX2 PAX8
10 positive regulation of cellular senescence GO:2000774 9.58 CDKN2A KRAS
11 replicative senescence GO:0090399 9.57 CDKN1A CDKN2A
12 mesonephros development GO:0001823 9.56 PAX2 PAX8
13 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.54 PAX2 PAX8
14 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.51 PAX2 PAX8
15 pronephros development GO:0048793 9.49 PAX2 PAX8
16 metanephric epithelium development GO:0072207 9.48 PAX2 PAX8
17 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX2 PAX8
18 metanephric nephron tubule formation GO:0072289 9.43 PAX2 PAX8
19 metanephric distal convoluted tubule development GO:0072221 9.4 PAX2 PAX8
20 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.37 PAX2 PAX8
21 positive regulation of metanephric DCT cell differentiation GO:2000594 9.32 PAX2 PAX8
22 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.26 PAX2 PAX8
23 pronephric field specification GO:0039003 9.16 PAX2 PAX8
24 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 8.96 PAX2 PAX8
25 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 8.62 PAX2 PAX8

Molecular functions related to Adenocarcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN1A CDKN2A

Sources for Adenocarcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....