MCID: ADN012
MIFTS: 43

Adenocarcinoma in Situ malady

Summaries for Adenocarcinoma in Situ

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33MalaCards
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MalaCards: Adenocarcinoma in Situ is related to adenocarcinoma and cervical intraepithelial neoplasia. An important gene associated with Adenocarcinoma in Situ is CDX2 (caudal type homeobox 2), and among its related pathways are Cell Cycle and Chronic myeloid leukemia. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include lymph node, small intestine and colon, and related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Adenocarcinoma in Situ

Sources:
8Disease Ontology, 10DISEASES, 57SNOMED-CT, 40NCIt, 61UMLS
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Aliases & Descriptions:

adenocarcinoma in situ 8 10


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Disease Ontology8 DOID:4943
SNOMED-CT57 51642000
NCIt40 C4123

Related Diseases for Adenocarcinoma in Situ

Sources:
17GeneCards, 18GeneDecks
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Diseases in the adenocarcinoma family:

adenocarcinoma in situ

Diseases related to Adenocarcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7CEACAM5, VIM, CEACAM7, ESR1, TMEFF2, KRT20
2cervical intraepithelial neoplasia30.7CDKN2A, IFI27
3adenoma30.5CEACAM5, CEACAM7, TMEFF2, KRT20, KRAS, CDKN1A
4barrett's esophagus30.4KRT20, MCM2, CDX2, CDKN2A
5squamous cell carcinoma30.4CDX2, CDKN2A, TOP2A, IFI27, VIM, CDKN1A
6bladder adenocarcinoma30.3CDX2, KRT20
7neuroendocrine carcinoma30.3CDX2, KRT20, CEACAM5
8cervix endometriosis30.0TOP2A, MCM2
9cervix uteri carcinoma in situ30.0GP5
10large cell carcinoma30.0KRAS, KRT20, CEACAM7, CEACAM5
11papillary carcinoma30.0IFI27, PGR, KRT20, ESR1
12barrett's adenocarcinoma10.3
13mucinous adenocarcinoma10.3
14lung papillary adenocarcinoma10.2
15cervical endometrioid adenocarcinoma10.2
16pleomorphic adenoma10.1
17small cell carcinoma10.1
18cervix squamous papilloma10.1
19cervix small cell carcinoma10.1
20papillary hidradenoma10.1
21gallbladder squamous cell carcinoma10.1
22anal gland adenocarcinoma10.1
23endometrioid ovary carcinoma10.1
24endometrial mucinous adenocarcinoma10.1
25ureter adenocarcinoma10.1
26renal pelvis adenocarcinoma10.1
27apocrine adenocarcinoma10.1
28appendix adenocarcinoma10.1
29bile duct adenocarcinoma10.1
30breast adenocarcinoma10.1
31vulva adenocarcinoma10.1
32esophagitis10.0CDX2
33esophageal cancer10.0CDKN2A
34pituitary adenoma10.0IFI27
35multiple myeloma10.0CDKN2A
36stomach cancer10.0CDX2
37cystadenocarcinoma10.0CEACAM5
38thymoma10.0IFI27
39cystadenoma10.0KRAS
40pancreatitis10.0KRAS
41testicular cancer10.0KRAS
42liver cirrhosis10.0KRAS
43angiosarcoma10.0VIM
44hepatitis c10.0KRAS
45benign mesothelioma10.0WT1
46atherosclerosis10.0IFI27
47secretory meningioma10.0VIM
48pseudomyxoma peritonei10.0KRT20, CDX2
49laryngeal carcinoma10.0IFI27
50hepatitis10.0KRAS

Graphical network of the top 20 diseases related to Adenocarcinoma in Situ:



Diseases related to adenocarcinoma in situ

Clinical Features for Adenocarcinoma in Situ

Drugs & Therapeutics for Adenocarcinoma in Situ

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenocarcinoma in Situ

Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma in Situ

Search NIH Clinical Center for Adenocarcinoma in Situ

Search CenterWatch for Adenocarcinoma in Situ

Genetic Tests for Adenocarcinoma in Situ

Anatomical Context for Adenocarcinoma in Situ

Sources:
33MalaCards
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MalaCards organs/tissues related to Adenocarcinoma in Situ:

33
Lymph node, Small intestine, Colon, Lung, Pancreas, Breast, Prostate, Cervix, Appendix, Pancreatic islet

Animal Models for Adenocarcinoma in Situ or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Adenocarcinoma in Situ

Sources:
51PubMed
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Articles related to Adenocarcinoma in Situ:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Risk of residual disease and invasive carcinoma in women treated for adenocarcinoma in situ of the cervix. (23541795)
2013
2
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma. (23591077)
2013
3
Cervical intraepithelial neoplasia grade 3 and adenocarcinoma in situ: comparison of ICD-9 codes and pathology results--Kaiser Permanente, United States, 2000-2005. (23563889)
2013
4
Common bile duct adenocarcinoma in a patient with situs inversus totalis: report of a rare case. (23234596)
2012
5
Incidentally Discovered Adenocarcinoma in situ of the Appendix in a Young Woman. (23275764)
2012
6
Assessment of invasion in lung adenocarcinoma classification, including adenocarcinoma in situ and minimally invasive adenocarcinoma. (22214965)
2012
7
Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus. (20518902)
2010
8
EGFR fluorescence in situ hybridization-positive lung adenocarcinoma: incidence of coexisting KRAS and BRAF mutations. (20381121)
2010
9
Primary appendiceal mucinous adenocarcinoma alongside with situs inversus totalis: a unique clinical case. (20525349)
2010
10
Vaginal clear cell adenocarcinoma with associated MA1llerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol. (19757709)
2009
11
Chromogenic in situ hybridization analysis of EGFR gene copies in colon adenocarcinoma based on intra-operative imprints and tissue microarrays. (19795022)
2009
12
Presence of endometrial adenocarcinoma in situ in complex atypical endometrial hyperplasia is associated with increased incidence of endometrial carcinoma in subsequent hysterectomy. (19116629)
2009
13
Pancreatic adenocarcinoma in a patient with situs inversus: a case report of this rare coincidence. (20021643)
2009
14
Significant decrease of adenocarcinoma in situ not reflected in cervical adenocarcinoma incidence in the Netherlands 1989-2003. (18182979)
2008
15
Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ. (18234283)
2008
16
Synchronous high-grade squamous intraepithelial lesion and adenocarcinoma in situ of cervix in a young woman presenting with hyperchromatic crowded groups in the cervical cytology specimen: report of a case. (18831021)
2008
17
Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients. (18304690)
2008
18
In situ and invasive components of mammary adenocarcinoma: comparison of Her-2/neu status. (17879632)
2007
19
IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression. (17192788)
2007
20
Comparative sensitivities of ThinPrep and Papanicolaou smear for adenocarcinoma in situ (AIS) and combined AIS/high-grade squamous intraepithelial lesion (HSIL): comparison with HSIL. (17969065)
2007
21
Effect of prophylactic human papillomavirus L1 virus-like-particle vaccine on risk of cervical intraepithelial neoplasia grade 2, grade 3, and adenocarcinoma in situ: a combined analysis of four randomised clinical trials. (17544766)
2007
22
Intestinal type adenocarcinoma in situ of the cervix. (17703459)
2007
23
Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa? (16829755)
2006
24
The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: a fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study. (16096413)
2005
25
Invasive cervical adenocarcinoma immediately following a cone biopsy for adenocarcinoma in situ with negative margins. (15913738)
2005
26
Use of interphase fluorescence in situ hybridization in prostate needle biopsy specimens with isolated high-grade prostatic intraepithelial neoplasia as a predictor of prostate adenocarcinoma on follow-up biopsy. (15017583)
2004
27
Management of adenocarcinoma in situ, micro-invasive, and early stage adenocarcinoma of the cervix. (11801877)
2002
28
Human papillomavirus and long-term oral contraceptive use increase the risk of adenocarcinoma in situ of the cervix. (11303584)
2001
29
Adenocarcinoma in situ and early invasive adenocarcinoma of the uterine cervix. (11555719)
2001
30
Invasive adenocarcinoma of the vagina following surgery for adenocarcinoma in situ of the cervix--recurrence or implantation? (11906556)
2001
31
Recurrent invasive adenocarcinoma after hysterectomy for cervical adenocarcinoma in situ. (10785491)
2000
32
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions. (9439892)
1997
33
Small-cell neuroendocrine carcinoma of the uterine cervix associated with micro-invasive squamous cell carcinoma and adenocarcinoma in situ. (8870009)
1996
34
Numerical aberration and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: analysis by fluorescence in situ hybridization (FISH) and PCR-SSCP. (8647618)
1996
35
Invasive adenocarcinoma of the cervix following Lletz for adenocarcinoma in situ. (8631562)
1996
36
High grade squamous intraepithelial lesion (CIN 3) with extension into the endocervical clefts. Difficulty of cytologic differentiation from adenocarcinoma in situ. (8842162)
1996
37
Invasive adenocarcinoma of the cervix following LLETZ (large loop excision of the transformation zone) for adenocarcinoma in situ. (7622120)
1995
38
Adenocarcinoma in situ of the gall bladder--an incidental finding. (8613166)
1994
39
Colposcopy of adenocarcinoma in situ and invasive adenocarcinoma of the cervix. (8332305)
1993
40
Expression of c-erbB-2 in in situ and in adjacent invasive ductal adenocarcinomas of the female breast. (1352687)
1992
41
The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia. (2298414)
1990
42
An adenocarcinoma in situ of the uterine cervix that developed into invasive adenocarcinoma after 5 years. (2295444)
1990
43
Nucleolar organiser regions in adenocarcinoma in situ and invasive adenocarcinoma of the cervix. (2401734)
1990
44
Endocervical glandular dysplasia, adenocarcinoma in situ, and early invasive (microinvasive) adenocarcinoma of the uterine cervix. (2171126)
1990
45
Human papillomavirus DNA in adenocarcinoma in situ, microinvasive adenocarcinoma of the uterine cervix, and coexisting cervical squamous intraepithelial neoplasia. (2540102)
1989
46
Modulation of the antigenicity of amylase in cervical glandular atypia, adenocarcinoma in situ and invasive adenocarcinoma. (2478438)
1989
47
Cervical intraepithelial glandular neoplasia (adenocarcinoma in situ and glandular dysplasia). A correlative study of 23 cases with histologic grading, histochemical analysis of mucins, and immunohistochemical determination of the affinity for four lectins. (3742451)
1986
48
Adenocarcinoma in situ and invasive adenocarcinoma of the uterine cervix. An immunohistologic study with antibodies specific for several epithelial markers. (6202386)
1984
49
Adenocarcinoma-in-situ of the cervix uteri associated with cervical intraepithelial neoplasia in pregnancy. Case report. (6722066)
1984
50
Adenocarcinoma-in-situ of the endocervix with co-existent intrauterine pregnancy: report of a case and review of the literature. (7168896)
1982

Genetic Variations for Adenocarcinoma in Situ

Expression for genes affiliated with Adenocarcinoma in Situ

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma in Situ

Search GEO for disease gene expression data for Adenocarcinoma in Situ.

Pathways for genes affiliated with Adenocarcinoma in Situ

Sources:
54Reactome, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database
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Compounds for genes affiliated with Adenocarcinoma in Situ

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 29IUPHAR
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Compounds related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1butyrate4510.5CEACAM7, CDX2
2estrogen4510.5CEACAM7, PDYN
3cycloheximide4510.5CEACAM7
4resveratrol45 60 11 2413.4PGR
5Ethynodiol Diacetate1110.3PGR, ESR1
6ici 1643844510.3PGR, ESR1
7temozolomide45 1111.2CDKN1A, CDKN2A, VIM
8nomegestrol acetate4510.1TOP2A, ESR1, PGR
9Allylestrenol1110.1ESR1, PGR
10taxane4510.1CDKN1A, PGR, ESR1
11p000484510.0IFI27, CDKN1A
12Etonogestrel1110.0PGR, ESR1
13roscovitine4510.0IFI27, VIM, CDKN2A, CDKN1A
14vincristine45 50 1111.9WT1, VIM, TOP2A
15irinotecan45 50 1111.9KRAS, CEACAM5, CDKN1A, CDKN2A
16eb 108945 6010.8ESR1, IFI27, CDKN1A
17hematoxylin459.8KRT20, CDKN2A, VIM, CEACAM5
18mucicarmine459.8VIM, CEACAM5, CEACAM7, KRT20
19trastuzumab45 50 1111.8TOP2A, PGR, ESR1, IFI27
20docetaxel45 50 60 1112.7TOP2A, ESR1, CDKN1A, CDKN2A, PGR
21methotrexate45 50 1111.7PGR, CDKN2A, TOP2A, VIM, ESR1
22chloramphenicol45 2 1111.7TOP2A, CDKN2A, ESR1, VIM, WT1
23optimax459.7IFI27, CDKN1A
24retinoid459.7ESR1, PGR, CDKN1A, VIM, IFI27
25agar459.7CEACAM5, PGR, CDKN1A, CDKN2A, VIM
26b 723459.6KRT20, CEACAM5, CEACAM7, VIM, WT1
27cytarabine45 50 1111.6VIM, IFI27, CDKN1A, CDKN2A, TOP2A
28thymidylate459.6CDKN1A, VIM, CDKN2A, TOP2A, IFI27
29tamoxifen45 50 29 1112.6PGR, ESR1, CDKN1A, VIM, IFI27
30ribonucleic acid459.6CEACAM5, KRT20, PGR, WT1, PDYN
31actinomycin d459.5CEACAM7, ESR1, CDKN1A, CDKN2A, TOP2A, VIM
32vitamin d459.4WT1, ESR1, VIM, IFI27, KRAS, CDX2
33p002459.4CEACAM5, IFI27, TOP2A, KRAS
34adriamycin459.4PGR, CDKN1A, CDKN2A, TOP2A, VIM, CEACAM5
35steroid459.3ESR1, CDX2, TOP2A, PDYN, WT1, IFI27
365-aza-2deoxycytidine459.3TMEFF2, CDKN2A, ESR1, VIM, CDX2, PGR
37oligonucleotide459.3VIM, CDX2, CDKN1A, KRAS, CDKN2A, WT1
38paclitaxel45 50 1111.3CDKN1A, KRAS, IFI27, ESR1, PGR, CDKN2A
39genistein45 29 60 2 11 2414.2VIM, IFI27, ESR1, TOP2A, CDKN2A, CDKN1A
40gefitinib45 50 1111.2IFI27, VIM, CEACAM5, CEACAM7, ESR1, KRAS
41cisplatin45 50 60 1112.2CDKN2A, CDKN1A, CEACAM5, IFI27, TOP2A, KRAS
42testosterone45 60 11 2412.0VIM, ESR1, KRT20, PGR, IFI27, WT1
435fluorouracil459.0TOP2A, CEACAM5, ESR1, CEACAM7, KRAS, PGR
44thymidine45 249.9TOP2A, CDX2, CDKN1A, CEACAM7, WT1, CEACAM5
45retinoic acid45 249.7WT1, ESR1, TOP2A, KRAS, CDKN2A, PGR
46doxorubicin45 50 1110.4VIM, KRT20, PGR, CDKN2A, ESR1, WT1
47vegf458.2KRT20, PGR, CDKN1A, CDKN2A, TOP2A, WT1
48tyrosine458.0IFI27, CDKN1A, MCM7, KRAS, KRT20, CEACAM5
49progesterone45 60 29 11 2411.9PGR, VIM, IFI27, PDYN, WT1, TOP2A
50paraffin457.8PGR, IFI27, WT1, VIM, MCM2, CDKN2A

GO Terms for genes affiliated with Adenocarcinoma in Situ

Sources:
16Gene Ontology
See all sources

Cellular components related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MCM complexGO:04255510.0MCM7, MCM2
2nucleoplasmGO:0056548.0ESR1, WT1, TOP2A, POLR2G, CDKN2A, CDKN1A

Biological processes related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1G1/S transition of mitotic cell cycleGO:00008210.1MCM7, MCM2
2positive regulation of nitric-oxide synthase activityGO:05100010.1ESR1, KRAS
3DNA unwinding involved in DNA replicationGO:00626810.0MCM7, MCM2
4negative regulation of gene expressionGO:0106299.9CDKN1A, PGR, ESR1
5Ras protein signal transductionGO:0072659.8CDKN2A, CDKN1A, KRAS
6intermediate filament organizationGO:0451099.7KRT20, VIM
7mitotic cell cycleGO:0002789.3TOP2A, CDKN2A, CDKN1A, MCM2, MCM7

Molecular functions related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.1CDKN1A, CDKN2A

Products for genes affiliated with Adenocarcinoma in Situ

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Sources for Adenocarcinoma in Situ

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet