MCID: ADN012
MIFTS: 53

Adenocarcinoma in Situ malady

Cancer diseases category
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Summaries for Adenocarcinoma in Situ

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33MalaCards
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MalaCards: Adenocarcinoma in Situ is related to adenocarcinoma and cervical adenocarcinoma. An important gene associated with Adenocarcinoma in Situ is CDX2 (caudal type homeobox 2), and among its related pathways are TP53 network and EGFR Transactivation by Gastrin. The compounds temozolomide and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include cervix, lung and testes, and related mouse phenotypes are pigmentation and vision/eye.

Aliases & Classifications for Adenocarcinoma in Situ

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8Disease Ontology, 10DISEASES, 58SNOMED-CT, 40NCIt, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenocarcinoma in situ 8 10


External Ids:

Disease Ontology8 DOID:4943
SNOMED-CT58 51642000
NCIt40 C4123

Related Diseases for Adenocarcinoma in Situ

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17GeneCards, 18GeneDecks
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Diseases in the Adenocarcinoma family:

adenocarcinoma in situ

Diseases related to Adenocarcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1EGFR, WT1, CDKN2A, CDKN1A, CDX2, KRT20
2cervical adenocarcinoma31.1CDKN2A, CDKN1A, CDX2, KRT20, IFI27, CEACAM7
3barrett's esophagus30.6CDKN2A, CDX2, KRT20, MCM2
4neuroendocrine carcinoma30.5CDX2, KRT20, CEACAM5
5lung adenocarcinoma30.3EGFR, CDKN2A, CDKN1A, CDX2, KRT20, KRAS
6lung cancer30.2EGFR, CDKN2A, CDKN1A, KRAS, ERBB2
7adenoma30.1CDKN2A, CDKN1A, CDX2, KRT20, KRAS, IFI27
8colon adenocarcinoma30.1CDKN1A, KRT20, KRAS, CEACAM7, CEACAM5
9endometrial carcinoma30.1EGFR, CDKN2A, KRAS, ERBB2, IFI27, ESR1
10papillary carcinoma30.0KRT20, ERBB2, IFI27, ESR1, PAX8, PGR
11cervical cancer30.0EGFR, CDKN2A, CDKN1A, ERBB2, IFI27
12retinoblastoma29.7EGFR, WT1, CDKN2A, CDKN1A, KRAS, ERBB2
13cervicitis11.0
14endocervicitis10.8
15cervical intraepithelial neoplasia10.4
16mucinous adenocarcinoma10.3
17endometrial adenocarcinoma10.2
18endometriosis10.2
19papillary adenocarcinoma10.2
20vaginitis10.2
21multicystic dysplastic kidney10.1PAX2
22cystadenocarcinoma10.1CEACAM5
23inverted papilloma10.1KRT20
24pseudomyxoma peritonei10.1CDX2, KRT20
25metanephric adenoma10.1WT1
26bladder adenocarcinoma10.1CDX2, KRT20
27secretory meningioma10.1VIM
28mucinous cystadenocarcinoma10.1KRT20, CEACAM7
29nephrogenic adenoma10.1PAX8, PAX2
30diffuse mesangial sclerosis10.1WT1, PAX2
31cerebral meningioma10.1PGR
32ovarian brenner tumor10.1WT1, KRT20
33cervix endometriosis10.1TOP2A, MCM2
34signet ring cell adenocarcinoma10.1KRT20, CEACAM5
35rectal neoplasm10.1IFI27, CEACAM5
36denys-drash syndrome10.1WT1, PAX2
37microinvasive gastric cancer10.1CDX2, CEACAM5
38cystadenoma10.1KRAS
39focal segmental glomerulosclerosis10.1WT1, IFI27, PAX2
40gallbladder cancer10.1CDX2, IFI27, CEACAM5
41malignant pleural mesothelioma10.1WT1, CEACAM7, CEACAM5
42adenomatoid tumor10.1WT1, VIM
43pleomorphic adenoma10.1
44small cell neuroendocrine carcinoma10.1
45large cell neuroendocrine carcinoma10.1
46papillary hidradenoma10.1
47endometrial mucinous adenocarcinoma10.1
48fallopian tube adenocarcinoma10.1
49hidradenoma10.1
50lupus erythematosus10.1

Graphical network of the top 20 diseases related to Adenocarcinoma in Situ:



Diseases related to adenocarcinoma in situ

Symptoms for Adenocarcinoma in Situ

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Drugs & Therapeutics for Adenocarcinoma in Situ

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma in Situ

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Genetic Tests for Adenocarcinoma in Situ

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Anatomical Context for Adenocarcinoma in Situ

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33MalaCards
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MalaCards organs/tissues related to Adenocarcinoma in Situ:

33
Cervix, Lung, Testes, Colon, Lymph node, Uterus, Ovary, Breast, Thyroid, Appendix

Animal Models for Adenocarcinoma in Situ or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Adenocarcinoma in Situ:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1MCM2, PAX2, KRAS, CDKN2A, EGFR
2MP:00053919.0VIM, KRAS, CDKN1A, CDKN2A, EGFR, PAX2
3MP:00053709.0ESR1, KRAS, CDKN1A, CDKN2A, WT1, EGFR
4MP:00053678.9PAX2, PAX8, ESR1, KRAS, CDKN1A, WT1
5MP:00053718.9PGR, ESR1, ERBB2, KRAS, CDX2, CDKN1A
6MP:00030128.9PGR, PAX8, ESR1, CDKN1A, CDKN2A, WT1
7MP:00053908.7PGR, PAX8, ESR1, ERBB2, CDX2, CDKN1A
8MP:00053818.5MCM2, ESR1, ERBB2, KRAS, CDX2, CDKN1A
9MP:00028738.4MCM2, PGR, ERBB2, KRAS, CDX2, WT1
10MP:00107718.3MCM2, PGR, ESR1, ERBB2, KRAS, CDKN1A
11MP:00020068.3MCM2, PGR, ESR1, ERBB2, KRAS, CDX2
12MP:00053888.2MCM2, ESR1, VIM, ERBB2, KRAS, CDKN1A
13MP:00053858.1PGR, PAX2, PAX8, ESR1, VIM, ERBB2
14MP:00053768.0VIM, ESR1, PAX8, PGR, ERBB2, KRAS
15MP:00053878.0MCM2, PGR, ESR1, VIM, KRAS, CDKN1A
16MP:00053698.0MCM2, PGR, ESR1, VIM, ERBB2, KRAS
17MP:00036317.9MCM2, PAX2, PAX8, ESR1, VIM, ERBB2
18MP:00053897.9PGR, PAX2, PAX8, ESR1, VIM, ERBB2
19MP:00053867.8MCM2, PGR, ESR1, VIM, ERBB2, KRAS
20MP:00053977.7MCM7, MCM2, PGR, ESR1, VIM, KRAS
21MP:00053797.7ESR1, PAX8, PAX2, PGR, MCM2, ERBB2
22MP:00053807.4EGFR, MCM2, PGR, PAX2, PAX8, ESR1
23MP:00053787.3VIM, ESR1, PAX8, MCM2, MCM7, ERBB2
24MP:00053846.9ESR1, PAX8, PAX2, PGR, MCM2, MCM7
25MP:00107686.9ESR1, PAX8, PAX2, PGR, MCM2, MCM7

Publications for Adenocarcinoma in Situ

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52PubMed
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Articles related to Adenocarcinoma in Situ:

(show top 50)    (show all 212)
idTitleAuthorsYear
1
Risk of residual disease and invasive carcinoma in women treated for adenocarcinoma in situ of the cervix. (23541795)
2013
2
Factors predicting the outcome of conservatively treated adenocarcinoma in situ of the uterine cervix: an analysis of 166 cases. (22188786)
2012
3
Fertility-sparing treatment in younger women with adenocarcinoma in situ of the cervix. (22030403)
2012
4
Predictive value of negative cone margin status for risk of residual disease among women with cervical adenocarcinoma in situ. (22939281)
2012
5
Using multi-detector-row CT to diagnose ampullary adenoma or adenocarcinoma in situ. (21093190)
2011
6
Cervical adenocarcinoma in situ with negative conization margin: negligible or not? (21607088)
2011
7
Pagetoid adenocarcinoma in situ of the cervix with pagetoid spread into the vagina. (21768854)
2011
8
Risk for residual adenocarcinoma in situ or cervical adenocarcinoma in women undergoing loop electrosurgical excision procedure/conization for adenocarcinoma in situ. (22010519)
2011
9
The safety of conization in the management of adenocarcinoma in situ of the uterine cervix. (21607092)
2011
10
Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme. (20423964)
2010
11
Metastatic carcinomas in the cervix mimicking primary cervical adenocarcinoma and adenocarcinoma in situ: report of a series of cases. (20414103)
2010
12
Simultaneous squamous cell carcinoma in situ and adenocarcinoma in situ of the uterine cervix in a 36-year-old Japanese woman. (19693522)
2010
13
A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. (19188825)
2009
14
Management of atypical glandular cells and adenocarcinoma in situ. (19061821)
2008
15
Significant decrease of adenocarcinoma in situ not reflected in cervical adenocarcinoma incidence in the Netherlands 1989-2003. (18182979)
2008
16
Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ. (18234283)
2008
17
Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2. (18156982)
2008
18
IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression. (17192788)
2007
19
Variants of human papillomavirus types 16 and 18: histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in cervical smear. (16990718)
2006
20
Can adenocarcinoma in situ of the uterine cervix be predicted before cervical conization? (17250421)
2006
21
Is improved detection of adenocarcinoma in situ by screening a key to reducing the incidence of cervical adenocarcinoma? (15471248)
2004
22
Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial. (14619639)
2003
23
Endocervical curettage at conization to predict residual cervical adenocarcinoma in situ. (12468353)
2002
24
Loss of heterozygosity on chromosome arms 3p and 6q in microdissected adenocarcinomas of the uterine cervix and adenocarcinoma in situ. (11857315)
2002
25
Management of adenocarcinoma in situ, micro-invasive, and early stage adenocarcinoma of the cervix. (11801877)
2002
26
Adenocarcinoma in situ of the cervix-controversies in diagnosis and treatment. (17043583)
2001
27
Conservative management of adenocarcinoma in situ of the cervix. (17043589)
2001
28
Atypical glandular cells of undetermined significance in cervical smears after conization. Cytologic features differentiating them from adenocarcinoma in situ. (11284300)
2001
29
Vaginal adenosis with adenocarcinoma in situ in a woman with no recognised antecedent factors. (11284657)
2001
30
Human papillomavirus and long-term oral contraceptive use increase the risk of adenocarcinoma in situ of the cervix. (11303584)
2001
31
Adenocarcinoma in situ with a small cell (endometrioid) pattern in cervical smears: a test of the distinction from benign mimics using specific criteria. (10536349)
1999
32
Adenocarcinoma in situ of the cervix: management and outcome. (10366458)
1999
33
Abnormal expression of sex steroid receptors and cell cycle-related molecules in adenocarcinoma in situ of the uterine cervix. (10202666)
1999
34
Comparison of ThinPrep and Pap smear in relation to prediction of adenocarcinoma in situ. (9987454)
1999
35
Re: Adenocarcinoma in situ of the uterine cervix progressing to invasive adenocarcinoma. (9075568)
1997
36
Adenocarcinoma in situ in Barrett's esophagus with stricture of 10-yr duration: a cytological diagnosis. (8759681)
1996
37
Atypical glandular cells of undetermined significance and adenocarcinoma in situ: summoning colposcopic expertise? (8708629)
1996
38
Small-cell neuroendocrine carcinoma of the uterine cervix associated with micro-invasive squamous cell carcinoma and adenocarcinoma in situ. (8870009)
1996
39
Adenocarcinoma in situ of the uterine cervix: management and outcome. (8641606)
1996
40
Management and follow-up of patients with adenocarcinoma in situ of the uterine cervix. (7729727)
1995
41
Adenocarcinoma in situ of the endocervix: human papillomavirus determination by dot blot hybridization and polymerase chain reaction amplification. (8005736)
1994
42
A clinicopathological study of adenocarcinoma in situ of the cervix. The influence of cervical HPV infection and other factors, and the role of conservative surgery. (1656927)
1991
43
The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia. (2298414)
1990
44
An adenocarcinoma in situ of the uterine cervix that developed into invasive adenocarcinoma after 5 years. (2295444)
1990
45
Cervical adenocarcinoma in situ. (3285263)
1988
46
The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri and related lesions. III. Pitfalls in diagnosis. (3376699)
1988
47
A retrospective review of adenocarcinoma-in-situ and glandular atypia of the uterine cervix. (3040074)
1987
48
Papillary adenocarcinoma in situ of bladder. (4032558)
1985
49
The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri. (266347)
1977
50
Simultaneous adenocarcinoma in situ and epidermoid carcinoma in situ. Report of two cases. (6073902)
1967

Variations for Adenocarcinoma in Situ

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Expression for genes affiliated with Adenocarcinoma in Situ

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma in Situ

Search GEO for disease gene expression data for Adenocarcinoma in Situ.

Pathways for genes affiliated with Adenocarcinoma in Situ

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG, 61Tocris Bioscience, 60Thomson Reuters, 51PharmGKB, 54R&D Systems, 5Cell Signaling Technology, 12EMD Millipore
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Pathways related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0CDKN1A, CDKN2A
2
Show member pathways
EGFR-dependent Endothelin signaling events38
9.9EGFR, KRAS
39.7EGFR, CDKN2A, CDKN1A
49.7EGFR, CDKN1A, KRAS
5
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.7EGFR, CDKN1A, KRAS
6
Show member pathways
9.7EGFR, KRAS, ERBB2
7
Show member pathways
9.7ERBB2, KRAS, EGFR
8
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.7CDKN1A, ESR1, PGR
9
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.7EGFR, CDKN1A, ERBB2
109.7ERBB2, CDKN1A, EGFR
11
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.6KRAS, ERBB2, ESR1
129.6ESR1, WT1, EGFR
139.6EGFR, KRAS, ESR1
14
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.6EGFR, ERBB2, ESR1
15
Show member pathways
9.4EGFR, CDKN1A, KRAS, ERBB2
16
Show member pathways
Signal transduction PTEN pathway60
9.4EGFR, CDKN1A, KRAS, ERBB2
17
Show member pathways
9.4ERBB2, KRAS, CDKN1A, EGFR
18
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.4ERBB2, KRAS, CDKN1A, EGFR
199.4ERBB2, KRAS, CDKN1A, EGFR
20
Show member pathways
9.4EGFR, CDKN1A, ERBB2, VIM
21
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3ESR1, ERBB2, KRAS, EGFR
22
Show member pathways
9.2ERBB2, KRAS, CDKN1A, CDKN2A, EGFR
23
Show member pathways
Signaling Pathways in Glioblastoma38
9.2ERBB2, KRAS, CDKN1A, CDKN2A, EGFR
24
Show member pathways
9.1ESR1, ERBB2, CDKN1A, CDKN2A, EGFR
259.1EGFR, CDKN1A, KRAS, ERBB2, ESR1
26
Show member pathways
9.0MCM7, MCM2, CDKN1A, CDKN2A
27
Show member pathways
Cell cycle38
9.0MCM7, MCM2, CDKN1A, CDKN2A
289.0PAX8, ERBB2, KRAS, CDKN1A, CDKN2A, EGFR
299.0CDKN1A, TOP2A, MCM7
308.9VIM, ERBB2, KRAS, CDKN1A, CDKN2A, EGFR
31
Show member pathways
8.9ESR1, VIM, ERBB2, CDKN1A, CDKN2A, EGFR
32
Show member pathways
8.8PGR, ESR1, ERBB2, KRAS, CDKN1A, EGFR
338.7MCM7, MCM2, TOP2A
34
Show member pathways
8.2MCM7, MCM2, TOP2A, CDKN1A, CDKN2A
35
Show member pathways
8.2CDKN2A, CDKN1A, TOP2A, MCM2, MCM7
368.1EGFR, WT1, CDKN1A, KRAS, ERBB2, TOP2A

Compounds for genes affiliated with Adenocarcinoma in Situ

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45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1temozolomide45 1110.7VIM, CDKN1A, CDKN2A, EGFR
2anastrozole45 51 1111.6ERBB2, ESR1, EGFR, PGR
3exemestane45 51 61 1112.6EGFR, ERBB2, ESR1, PGR
4lapatinib45 51 1111.6ESR1, ERBB2, EGFR, PGR
5fulvestrant45 51 29 1112.5EGFR, ERBB2, ESR1, PGR
6taxane459.5EGFR, ERBB2, ESR1, PGR, CDKN1A
7letrozole45 51 61 1112.5PGR, EGFR, ERBB2, ESR1
84-hydroxytamoxifen459.4EGFR, ERBB2, VIM, PGR, ESR1
9tetracycline45 1110.4CDKN2A, EGFR, WT1, ERBB2, IFI27
105-aza-2deoxycytidine459.3PGR, CDKN2A, CDKN1A, ESR1, VIM, CDX2
11progestin459.3VIM, ERBB2, PGR, EGFR, ESR1
12geldanamycin45 51 61 1112.2CDKN1A, PGR, ERBB2, EGFR, ESR1
13mucicarmine459.2CEACAM7, CEACAM5, VIM, KRT20
14oxaliplatin45 51 1111.1EGFR, KRAS, CDKN1A, ERBB2, CEACAM5
15leucovorin45 51 1111.1CEACAM5, ERBB2, KRAS, PGR, EGFR
16b 723459.0WT1, VIM, CEACAM5, CEACAM7, KRT20
17irinotecan45 51 1111.0ERBB2, EGFR, CDKN2A, CDKN1A, KRAS, CEACAM5
18retinoid458.9ESR1, PGR, EGFR, VIM, IFI27, CDKN1A
19oligonucleotide458.8IFI27, PAX8, WT1, CDKN2A, CDKN1A, VIM
20tamoxifen45 51 29 1111.8ERBB2, PGR, EGFR, ESR1, CDKN1A, VIM
21rapamycin458.8EGFR, KRAS, ERBB2, IFI27, VIM, CDKN1A
22vitamin d458.8CDKN1A, KRAS, ERBB2, IFI27, ESR1, CDX2
23resveratrol45 61 24 1111.7PGR, ESR1, IFI27, ERBB2, CDKN1A
24agar458.7ERBB2, EGFR, VIM, CEACAM5, PGR, CDKN1A
25cycloheximide458.6VIM, CEACAM7, ERBB2, CDKN1A, CDKN2A, EGFR
26methotrexate51 45 1110.6PGR, ESR1, VIM, ERBB2, TOP2A, CDKN2A
27cytarabine45 51 1110.6CDKN1A, VIM, TOP2A, IFI27, CDKN2A
28chloramphenicol45 3 51 1111.6ESR1, VIM, TOP2A, WT1, CDKN2A, ERBB2
29trastuzumab45 51 1110.5IFI27, TOP2A, ESR1, ERBB2, EGFR, PGR
30docetaxel45 51 61 1111.5CDKN2A, TOP2A, EGFR, CDKN1A, ERBB2, ESR1
31thymidylate458.4ERBB2, TOP2A, IFI27, VIM, CDKN1A, CDKN2A
32butyrate458.2CDKN2A, IFI27, KRAS, CDX2, CDKN1A, CEACAM5
33adriamycin458.2PGR, VIM, TOP2A, CEACAM5, ERBB2, CDKN2A
34p002458.0KRAS, ERBB2, IFI27, TOP2A, CEACAM5
35gefitinib45 51 119.9ERBB2, IFI27, CEACAM7, CEACAM5, VIM, ESR1
36genistein45 29 61 3 24 1112.8EGFR, CDKN1A, ERBB2, IFI27, TOP2A, VIM
37thymidine45 248.7TOP2A, CEACAM5, WT1, CEACAM7, IFI27, CDX2
38paclitaxel45 51 119.6EGFR, CDKN2A, CDKN1A, KRAS, ERBB2, IFI27
39steroid457.6CDX2, CEACAM5, TOP2A, ESR1, PGR, WT1
40cisplatin45 51 61 1110.5ERBB2, EGFR, CDKN2A, CDKN1A, KRAS, IFI27
41testosterone45 61 24 1110.4KRT20, VIM, ESR1, CDKN2A, WT1, EGFR
42serine457.4PAX8, EGFR, ERBB2, KRAS, CDKN1A, WT1
43retinoic acid45 248.3WT1, TOP2A, VIM, CDKN1A, PGR, EGFR
445fluorouracil457.3EGFR, CDKN2A, CDKN1A, KRAS, ERBB2, CEACAM7
45doxorubicin45 51 118.6EGFR, WT1, CDKN2A, CDKN1A, KRT20, ERBB2
46vegf456.4TOP2A, IFI27, KRAS, KRT20, CDKN1A, CDKN2A
47progesterone45 29 61 24 1110.1EGFR, WT1, CDKN2A, CDKN1A, CDX2, KRT20
48tyrosine456.0IFI27, KRT20, IGF2BP3, KRAS, ERBB2, CEACAM5
49paraffin455.7KRAS, ERBB2, IFI27, TOP2A, VIM, ESR1
50estrogen455.3WT1, ESR1, PGR, MCM2, VIM, TOP2A

GO Terms for genes affiliated with Adenocarcinoma in Situ

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16Gene Ontology
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Cellular components related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.3EGFR, ERBB2, CEACAM5
2MCM complexGO:0425559.2MCM2, MCM7
3nucleolusGO:0057307.5MCM7, MCM2, PAX8, TOP2A, CDX2, CDKN1A
4nucleoplasmGO:0056547.3WT1, MCM7, MCM2, PGR, PAX8, ESR1
5nucleusGO:0056346.0PAX8, PAX2, MCM2, MCM7, IGF2BP3, ESR1

Biological processes related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show all 48)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of metanephric DCT cell differentiationGO:200059410.5PAX2, PAX8
2negative regulation of apoptotic process involved in metanephric nephron tubule developmentGO:190021810.5PAX2, PAX8
3negative regulation of apoptotic process involved in metanephric collecting duct developmentGO:190021510.5PAX2, PAX8
4negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesisGO:07230510.5PAX2, PAX8
5pronephric field specificationGO:03900310.5PAX2, PAX8
6negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentGO:190021210.5PAX2, PAX8
7regulation of metanephric nephron tubule epithelial cell differentiationGO:07230710.5PAX2, PAX8
8metanephric nephron tubule formationGO:07228910.5PAX2, PAX8
9metanephric distal convoluted tubule developmentGO:07222110.5PAX2, PAX8
10positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:07210810.5PAX2, PAX8
11metanephric S-shaped body morphogenesisGO:07228410.4WT1, PAX8
12pronephros developmentGO:04879310.4PAX2, PAX8
13mesenchymal to epithelial transitionGO:06023110.4PAX2, WT1
14mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00333710.4PAX2, PAX8
15metanephric mesenchyme developmentGO:07207510.4PAX2, WT1
16negative regulation of immature T cell proliferation in thymusGO:03308810.4ERBB2, CDKN2A
17mesonephros developmentGO:00182310.3PAX8, PAX2
18metanephric epithelium developmentGO:07220710.3WT1, PAX8, PAX2
19cellular response to gonadotropin stimulusGO:07137110.3WT1, PAX8
20urogenital system developmentGO:00165510.3PAX8, PAX2
21branching involved in ureteric bud morphogenesisGO:00165810.3PAX2, PAX8, WT1
22Ras protein signal transductionGO:00726510.1KRAS, CDKN1A, CDKN2A
23positive regulation of nitric-oxide synthase activityGO:05100010.1KRAS, ESR1
24positive regulation of branching involved in ureteric bud morphogenesisGO:09019010.1PAX2, PAX8
25positive regulation of MAP kinase activityGO:04340610.1ERBB2, KRAS, EGFR
26intermediate filament organizationGO:04510910.1KRT20, VIM
27positive regulation of epithelial cell proliferationGO:05067910.0EGFR, ERBB2, PAX2
28negative regulation of phosphorylationGO:04232610.0CDKN2A, CDKN1A
29positive regulation of fibroblast proliferationGO:04814610.0EGFR, CDKN1A, ESR1
30negative regulation of gene expressionGO:01062910.0CDKN1A, ESR1, PGR
31cellular response to estradiol stimulusGO:07139210.0EGFR, ESR1
32cellular response to epidermal growth factor stimulusGO:07136410.0MCM7, PAX2, EGFR
33negative regulation of cell growthGO:03030810.0CDKN1A, CDKN2A, WT1
34negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.9CDKN2A, CDKN1A
35positive regulation of protein phosphorylationGO:0019349.9ERBB2, KRAS, EGFR
36fibroblast growth factor receptor signaling pathwayGO:0085439.8EGFR, CDKN1A, KRAS, ERBB2
37positive regulation of transcription, DNA-templatedGO:0458939.8PAX2, PAX8, CDX2, CDKN2A, WT1
38Fc-epsilon receptor signaling pathwayGO:0380959.8ERBB2, KRAS, CDKN1A, EGFR
39DNA unwinding involved in DNA replicationGO:0062689.8MCM7, MCM2
40epidermal growth factor receptor signaling pathwayGO:0071739.8ERBB2, KRAS, CDKN1A, EGFR
41cellular senescenceGO:0903989.7CDKN2A, CDKN1A
42neurotrophin TRK receptor signaling pathwayGO:0480119.7ERBB2, KRAS, CDKN1A, EGFR
43G1/S transition of mitotic cell cycleGO:0000829.5CDKN2A, CDKN1A, MCM2, MCM7
44negative regulation of apoptotic processGO:0430669.3EGFR, WT1, CDKN1A, CEACAM5, PAX2
45phosphatidylinositol-mediated signalingGO:0480159.3TOP2A, ERBB2, CDKN1A, EGFR
46DNA replicationGO:0062608.7TOP2A, MCM2, MCM7
47positive regulation of transcription from RNA polymerase II promoterGO:0459448.6PAX2, PAX8, ESR1, TOP2A, CDKN2A, WT1
48mitotic cell cycleGO:0002788.6MCM7, MCM2, TOP2A, CDKN1A, CDKN2A

Molecular functions related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00500610.1EGFR, ERBB2
2C2H2 zinc finger domain bindingGO:07074210.1WT1, PAX2
3nitric-oxide synthase regulator activityGO:0302359.9EGFR, ESR1
4receptor signaling protein tyrosine kinase activityGO:0047169.8EGFR, ERBB2
5cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.7CDKN2A, CDKN1A
6enzyme bindingGO:0198998.9PGR, ESR1, TOP2A, EGFR
7identical protein bindingGO:0428028.8ESR1, VIM, CEACAM5, ERBB2, EGFR
8DNA bindingGO:0036777.8MCM7, MCM2, PGR, PAX2, PAX8, TOP2A
9protein bindingGO:0055155.2EGFR, IGF2BP3, MCM7, MCM2, PGR, PAX2

Products for genes affiliated with Adenocarcinoma in Situ

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet