MCID: ADN012
MIFTS: 48

Adenocarcinoma in Situ malady

Summaries for Adenocarcinoma in Situ

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MalaCards: Adenocarcinoma in Situ is related to adenocarcinoma and cervical adenocarcinoma. An important gene associated with Adenocarcinoma in Situ is CDX2 (caudal type homeobox 2), and among its related pathways are Cell Cycle and Chronic myeloid leukemia. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include cervix, lung and testes, and related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Adenocarcinoma in Situ

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8Disease Ontology, 10DISEASES, 56SNOMED-CT, 39NCIt, 60UMLS
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Aliases & Descriptions:

adenocarcinoma in situ 8 10


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Disease Ontology8 DOID:4943
SNOMED-CT56 51642000
NCIt39 C4123

Related Diseases for Adenocarcinoma in Situ

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17GeneCards, 18GeneDecks
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Diseases in the Adenocarcinoma family:

adenocarcinoma in situ

Diseases related to Adenocarcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7VIM, IFI27, WT1, TOP2A, CDKN2A, CDX2
2cervical adenocarcinoma31.3PGR, CDKN1A, CDX2, CDKN2A, IFI27, CEACAM5
3lung adenocarcinoma30.7CDKN1A, CEACAM5, CDX2, CDKN2A, CEACAM7, TOP2A
4barrett's esophagus30.4KRT20, MCM2, CDX2, CDKN2A
5squamous cell carcinoma30.3TOP2A, VIM, IFI27, CDKN2A, CEACAM5, KRT20
6bladder adenocarcinoma30.2KRT20, CDX2
7endometriosis30.2ESR1, PGR
8neuroendocrine carcinoma30.2CDX2, KRT20, CEACAM5
9colon adenocarcinoma30.2CDKN1A, CEACAM5, CEACAM7, KRT20, KRAS
10endometrial carcinoma30.2KRAS, PGR, CDKN2A, ESR1, IFI27
11lung cancer30.2TOP2A, CDKN1A, CEACAM5, CEACAM7, CDX2, CDKN2A
12adenoma30.2CDKN1A, KRAS, KRT20, TMEFF2, CEACAM7, CEACAM5
13cervix endometriosis30.0MCM2, TOP2A
14large cell carcinoma30.0KRT20, KRAS, CEACAM5, CEACAM7
15papillary carcinoma30.0KRT20, ESR1, PGR, IFI27
16gastric adenocarcinoma30.0CDX2, TOP2A, CEACAM7, KRAS, CEACAM5, KRT20
17cervical cancer30.0CDKN2A, GP5, CEACAM7, KRAS, CDKN1A, TOP2A
18retinoblastoma30.0TOP2A, CDKN1A, ESR1, KRAS, MCM7, CDKN2A
19cervicitis10.9
20endocervicitis10.8
21in situ carcinoma10.6
22mucinous adenocarcinoma10.3
23endometrial adenocarcinoma10.3
24papillary adenocarcinoma10.3
25barrett's adenocarcinoma10.3
26esophagus adenocarcinoma10.3
27lung carcinoma in situ10.2
28lung papillary adenocarcinoma10.2
29cervical endometrioid adenocarcinoma10.2
30fallopian tube adenocarcinoma10.2
31gallbladder adenocarcinoma10.2
32hidradenoma10.2
33vaginitis10.2
34pleomorphic adenoma10.0
35uterus carcinoma in situ10.0
36small cell carcinoma10.0
37cervix small cell carcinoma10.0
38papillary hidradenoma10.0
39gallbladder squamous cell carcinoma10.0
40endometrial mucinous adenocarcinoma10.0
41ureter adenocarcinoma10.0
42renal pelvis adenocarcinoma10.0
43apocrine adenocarcinoma10.0
44appendix adenocarcinoma10.0
45bile duct adenocarcinoma10.0
46breast adenocarcinoma10.0
47breast carcinoma in situ10.0
48cervical mucinous adenocarcinoma10.0
49lupus erythematosus10.0
50ovary adenocarcinoma10.0

Graphical network of the top 20 diseases related to Adenocarcinoma in Situ:



Diseases related to adenocarcinoma in situ

Clinical Features for Adenocarcinoma in Situ

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Drugs & Therapeutics for Adenocarcinoma in Situ

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Adenocarcinoma in Situ

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Anatomical Context for Adenocarcinoma in Situ

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32MalaCards
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MalaCards organs/tissues related to Adenocarcinoma in Situ:

32
Cervix, Lung, Testes, Colon, Prostate, Breast, Lymph node, Uterus, Ovary, Thyroid, Pancreas, Appendix

Animal Models for Adenocarcinoma in Situ or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenocarcinoma in Situ:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.1PGR, MCM2, VIM
2MP:00053899.8WT1, CDKN2A, CDX2, CDKN1A, KRAS
3MP:00053799.7WT1, CDKN2A, CDX2, CDKN1A, KRAS
4MP:00053889.7ESR1, KRAS, MCM2, CDKN1A
5MP:00053699.7WT1, CDKN2A, CDKN1A, MCM2, ESR1
6MP:00107719.4PDYN, CDKN2A, CDKN1A, KRAS
7MP:00053769.4PDYN, CDX2, PGR, GP5, ESR1
8MP:00053819.2PDYN, CDKN2A, CDX2, CDKN1A, MCM2, KRAS
9MP:00020068.9ESR1, CDKN2A, CDX2, CDKN1A, MCM2, PGR
10MP:00053978.8CDKN2A, CDKN1A, MCM2, MCM7, PGR, KRAS
11MP:00053848.5VIM, WT1, CDKN2A, CDX2, CDKN1A, MCM2
12MP:00053788.2VIM, PDYN, WT1, CDKN2A, CDX2, CDKN1A
13MP:00107688.0CDX2, CDKN2A, WT1, VIM, CDKN1A, MCM2

Publications for Adenocarcinoma in Situ

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50PubMed
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Articles related to Adenocarcinoma in Situ:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinoma. (24283861)
2013
2
Cervical conization of adenocarcinoma in situ: a predicting model of residual disease. (24370689)
2013
3
Conization using the Shimodaira-Taniguchi procedure for adenocarcinoma in situ of the uterine cervix. (23395556)
2013
4
The value of CT attenuation in distinguishing atypical adenomatous hyperplasia from adenocarcinoma in situ. (24229623)
2013
5
Cervical intraepithelial neoplasia grade 3 and adenocarcinoma in situ: comparison of ICD-9 codes and pathology results--Kaiser Permanente, United States, 2000-2005. (23563889)
2013
6
Fertility-sparing treatment in younger women with adenocarcinoma in situ of the cervix. (22030403)
2012
7
Incidentally Discovered Adenocarcinoma in situ of the Appendix in a Young Woman. (23275764)
2012
8
The safety of conization in the management of adenocarcinoma in situ of the uterine cervix. (21607092)
2011
9
HER2 status in gastro-oesophageal adenocarcinomas assessed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridization methods (FISH and SISH). (21323962)
2011
10
Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder. (20040392)
2010
11
Simultaneous squamous cell carcinoma in situ and adenocarcinoma in situ of the uterine cervix in a 36-year-old Japanese woman. (19693522)
2010
12
Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus. (20518902)
2010
13
The role of loop electrosurgical excisional procedure in the management of adenocarcinoma in situ of the uterine cervix. (19428171)
2009
14
Pancreatic adenocarcinoma in a patient with situs inversus: a case report of this rare coincidence. (20021643)
2009
15
Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2. (18156982)
2008
16
IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression. (17192788)
2007
17
Fertility-sparing surgery in 101 women with adenocarcinoma in situ of the cervix. (17689593)
2007
18
Variants of human papillomavirus types 16 and 18: histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in cervical smear. (16990718)
2006
19
Villoglandular adenocarcinoma in situ of intestinal type of the hymen: de novo origin from squamous mucosa? (16829755)
2006
20
Is laser conization adequate for therapeutic excision of adenocarcinoma in situ of the uterine cervix? (15916663)
2005
21
Management of cervical adenocarcinoma in situ during pregnancy. (15902134)
2005
22
An investigation of the mechanisms underlying the disparity between rate of residual endocervical adenocarcinoma in situ (AIS) in hysterectomy specimens and clinical failure rate following conservatively treated AIS. (15487451)
2004
23
Adenocarcinoma in situ coexisting with carcinoma in situ of the cervix during pregnancy. (15449069)
2004
24
Postconization surveillance of cervical adenocarcinoma in situ. A prospective trial. (14619639)
2003
25
The presence of high-risk HPV combined with specific p53 and p16INK4a expression patterns points to high-risk HPV as the main causative agent for adenocarcinoma in situ and adenocarcinoma of the cervix. (14648656)
2003
26
Endocervical curettage at conization to predict residual cervical adenocarcinoma in situ. (12468353)
2002
27
Adenocarcinoma in situ of the cervix. (12478680)
2002
28
Symposium part I: adenocarcinoma in situ, glandular dysplasia, and early invasive adenocarcinoma of the uterine cervix. (12352181)
2002
29
Conservative management of adenocarcinoma in situ of the cervix. (17043589)
2001
30
Vaginal adenosis with adenocarcinoma in situ in a woman with no recognised antecedent factors. (11284657)
2001
31
Large cell neuroendocrine carcinoma of the cervix associated with adenocarcinoma in situ: evidence of a common origin. (11444207)
2001
32
Is conservative treatment for adenocarcinoma in situ of the cervix safe? (11762660)
2001
33
Gastric choriocarcinoma shows characteristics of adenocarcinoma and gestational choriocarcinoma: a comparative genomic hybridization and fluorescence in situ hybridization study. (11552718)
2001
34
Endocervical adenocarcinoma in situ: an analysis of cellular features. (9360044)
1997
35
Numerical aberration and point mutation of p53 gene in human gastric intestinal metaplasia and well-differentiated adenocarcinoma: analysis by fluorescence in situ hybridization (FISH) and PCR-SSCP. (8647618)
1996
36
Endocervical tubal metaplasia and adenocarcinoma in situ: role of immunohistochemistry for carcinoembryonic antigen and vimentin in differential diagnosis. (8803599)
1996
37
The suitable treatment for adenocarcinoma in situ of uterine cervix: a report of four cases. (8994337)
1996
38
High grade squamous intraepithelial lesion (CIN 3) with extension into the endocervical clefts. Difficulty of cytologic differentiation from adenocarcinoma in situ. (8842162)
1996
39
Low prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma in situ, invasive adenocarcinoma, and glandular dysplasia by polymerase chain reaction. (8415587)
1993
40
Expression of c-erbB-2 in in situ and in adjacent invasive ductal adenocarcinomas of the female breast. (1352687)
1992
41
Adenocarcinoma in situ of the uterine cervix. (1448263)
1992
42
Human papillomavirus type 16/18 in uterine cervical adenocarcinoma in situ and adenocarcinoma. A study by in situ hybridization with biotinylated DNA probes. (2159841)
1990
43
Concomitant endometrioid carcinoma of the ovary and endometrial carcinoma of the uterus associated with adenocarcinoma in situ of the cervix. (2603274)
1989
44
Prostate adenocarcinoma: effects of castration on in situ androgen uptake by individual cell types. (3795357)
1987
45
Squamous cell carcinoma of the gallbladder associated with squamous metaplasia and adenocarcinoma in situ of the mucosal columnar epithelium. (3825536)
1986
46
Adenocarcinoma-in-situ of the endocervix with co-existent intrauterine pregnancy: report of a case and review of the literature. (7168896)
1982
47
Diagnosis: adenocarcinoma in situ of the uterine cervix. (7465250)
1980
48
Adenocarcinoma in situ of the cervix during pregnancy. (503401)
1979
49
Adenocarcinoma in situ of Barrett's esophagus diagnosed by endoscopic cytology. (4411868)
1974
50
In situ carcinoma of cervix. Co-existing epidermoid carcinoma and adenocarcinoma. (5762754)
1969

Genetic Variations for Adenocarcinoma in Situ

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Expression for genes affiliated with Adenocarcinoma in Situ

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma in Situ

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Pathways for genes affiliated with Adenocarcinoma in Situ

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53Reactome, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database
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Compounds for genes affiliated with Adenocarcinoma in Situ

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 28IUPHAR
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Compounds related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5CEACAM7, CDX2
2estrogen4410.5CEACAM7, PDYN
3cycloheximide4410.5CEACAM7
4resveratrol44 59 11 2413.4PGR
5Ethynodiol Diacetate1110.3ESR1, PGR
6ici 1643844410.3PGR, ESR1
7temozolomide44 1111.2CDKN1A, CDKN2A, VIM
8nomegestrol acetate4410.1TOP2A, ESR1, PGR
9Etonogestrel1110.1ESR1, PGR
10idoxifene4410.1PGR, ESR1
11taxane4410.1ESR1, PGR, CDKN1A
12roscovitine4410.0IFI27, VIM, CDKN2A, CDKN1A
13vincristine44 49 1111.9VIM, TOP2A, WT1
14irinotecan44 49 1111.9KRAS, CEACAM5, CDKN1A, CDKN2A
15optimax449.9IFI27, CDKN1A
16eb 108944 5910.8ESR1, IFI27, CDKN1A
17hematoxylin449.8KRT20, CDKN2A, VIM, CEACAM5
18mucicarmine449.8VIM, CEACAM5, CEACAM7, KRT20
19trastuzumab44 49 1111.8TOP2A, PGR, ESR1, IFI27
20docetaxel44 49 59 1112.7TOP2A, ESR1, CDKN1A, CDKN2A, PGR
21methotrexate44 49 1111.7PGR, CDKN2A, TOP2A, VIM, ESR1
22chloramphenicol44 2 1111.7TOP2A, CDKN2A, ESR1, VIM, WT1
23p00048449.7IFI27, CDKN1A
24retinoid449.7ESR1, PGR, CDKN1A, VIM, IFI27
25agar449.7CEACAM5, PGR, CDKN1A, CDKN2A, VIM
26b 723449.6KRT20, CEACAM5, CEACAM7, VIM, WT1
27cytarabine44 49 1111.6VIM, IFI27, CDKN1A, CDKN2A, TOP2A
28thymidylate449.6CDKN1A, VIM, CDKN2A, TOP2A, IFI27
29tamoxifen44 49 28 1112.6CDKN1A, IFI27, PGR, VIM, ESR1
30ribonucleic acid449.6PDYN, WT1, PGR, KRT20, CEACAM5
31actinomycin d449.5CEACAM7, ESR1, CDKN1A, CDKN2A, TOP2A, VIM
32vitamin d449.4WT1, ESR1, VIM, IFI27, KRAS, CDX2
33p002449.4KRAS, TOP2A, IFI27, CEACAM5
34adriamycin449.4PGR, CDKN1A, CDKN2A, TOP2A, VIM, CEACAM5
35steroid449.3ESR1, CDX2, TOP2A, PDYN, WT1, IFI27
365-aza-2deoxycytidine449.3TMEFF2, CDKN2A, ESR1, VIM, CDX2, PGR
37oligonucleotide449.3VIM, CDX2, CDKN1A, KRAS, CDKN2A, WT1
38paclitaxel44 49 1111.3CDKN1A, KRAS, IFI27, ESR1, PGR, CDKN2A
39genistein44 28 59 2 11 2414.2VIM, IFI27, ESR1, TOP2A, CDKN2A, CDKN1A
40gefitinib44 49 1111.2IFI27, VIM, CEACAM5, CEACAM7, ESR1, KRAS
41cisplatin44 49 59 1112.2CDKN2A, CDKN1A, CEACAM5, KRAS, IFI27, TOP2A
42testosterone44 59 11 2412.0VIM, ESR1, KRT20, PGR, IFI27, WT1
435fluorouracil449.0TOP2A, CEACAM5, ESR1, CEACAM7, KRAS, PGR
44thymidine44 249.9TOP2A, CDX2, CDKN1A, CEACAM7, WT1, CEACAM5
45retinoic acid44 249.7WT1, ESR1, TOP2A, KRAS, CDKN2A, PGR
46doxorubicin44 49 1110.4VIM, KRT20, PGR, CDKN2A, ESR1, WT1
47vegf448.2KRT20, PGR, CDKN1A, CDKN2A, TOP2A, WT1
48tyrosine448.0IFI27, CDKN1A, MCM7, KRAS, KRT20, CEACAM5
49progesterone44 59 28 11 2411.9PGR, VIM, IFI27, PDYN, WT1, TOP2A
50paraffin447.8PGR, IFI27, WT1, VIM, MCM2, CDKN2A

GO Terms for genes affiliated with Adenocarcinoma in Situ

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16Gene Ontology
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Cellular components related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MCM complexGO:04255510.0MCM7, MCM2
2nucleoplasmGO:0056548.0ESR1, WT1, TOP2A, POLR2G, CDKN2A, CDKN1A

Biological processes related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1G1/S transition of mitotic cell cycleGO:00008210.1MCM7, MCM2
2positive regulation of nitric-oxide synthase activityGO:05100010.1ESR1, KRAS
3DNA unwinding involved in DNA replicationGO:00626810.0MCM7, MCM2
4negative regulation of gene expressionGO:0106299.9CDKN1A, PGR, ESR1
5Ras protein signal transductionGO:0072659.8CDKN2A, CDKN1A, KRAS
6intermediate filament organizationGO:0451099.7KRT20, VIM
7mitotic cell cycleGO:0002789.3MCM7, MCM2, CDKN1A, CDKN2A, TOP2A

Molecular functions related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.1CDKN1A, CDKN2A

Products for genes affiliated with Adenocarcinoma in Situ

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Sources for Adenocarcinoma in Situ

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet