MCID: ADN012
MIFTS: 48

Adenocarcinoma in Situ malady

Summaries for Adenocarcinoma in Situ

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MalaCards: Adenocarcinoma in Situ is related to adenocarcinoma and cervical adenocarcinoma. An important gene associated with Adenocarcinoma in Situ is CDX2 (caudal type homeobox 2), and among its related pathways are Cell Cycle and Chronic myeloid leukemia. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include cervix, lung and testes, and related mouse phenotypes are embryogenesis and reproductive system.

Aliases & Classifications for Adenocarcinoma in Situ

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8Disease Ontology, 10DISEASES, 56SNOMED-CT, 39NCIt, 60UMLS
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Aliases & Descriptions:

adenocarcinoma in situ 8 10


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Disease Ontology8 DOID:4943
SNOMED-CT56 51642000
NCIt39 C4123

Related Diseases for Adenocarcinoma in Situ

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17GeneCards, 18GeneDecks
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Diseases in the Adenocarcinoma family:

adenocarcinoma in situ

Diseases related to Adenocarcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.7VIM, IFI27, WT1, TOP2A, CDKN2A, CDX2
2cervical adenocarcinoma31.3PGR, CDKN1A, CDX2, CDKN2A, IFI27, CEACAM5
3lung adenocarcinoma30.7CDKN1A, CEACAM5, CDX2, CDKN2A, CEACAM7, TOP2A
4barrett's esophagus30.4KRT20, MCM2, CDX2, CDKN2A
5squamous cell carcinoma30.3TOP2A, VIM, IFI27, CDKN2A, CEACAM5, KRT20
6bladder adenocarcinoma30.2KRT20, CDX2
7endometriosis30.2ESR1, PGR
8neuroendocrine carcinoma30.2CDX2, KRT20, CEACAM5
9colon adenocarcinoma30.2CDKN1A, CEACAM5, CEACAM7, KRT20, KRAS
10endometrial carcinoma30.2KRAS, PGR, CDKN2A, ESR1, IFI27
11lung cancer30.2TOP2A, CDKN1A, CEACAM5, CEACAM7, CDX2, CDKN2A
12adenoma30.2CDKN1A, KRAS, KRT20, TMEFF2, CEACAM7, CEACAM5
13cervix endometriosis30.0MCM2, TOP2A
14large cell carcinoma30.0KRT20, KRAS, CEACAM5, CEACAM7
15papillary carcinoma30.0KRT20, ESR1, PGR, IFI27
16gastric adenocarcinoma30.0CDX2, TOP2A, CEACAM7, KRAS, CEACAM5, KRT20
17cervical cancer30.0CDKN2A, GP5, CEACAM7, KRAS, CDKN1A, TOP2A
18retinoblastoma30.0TOP2A, CDKN1A, ESR1, KRAS, MCM7, CDKN2A
19cervicitis10.9
20endocervicitis10.8
21in situ carcinoma10.6
22mucinous adenocarcinoma10.3
23endometrial adenocarcinoma10.3
24papillary adenocarcinoma10.3
25barrett's adenocarcinoma10.3
26esophagus adenocarcinoma10.3
27lung carcinoma in situ10.2
28lung papillary adenocarcinoma10.2
29cervical endometrioid adenocarcinoma10.2
30fallopian tube adenocarcinoma10.2
31gallbladder adenocarcinoma10.2
32hidradenoma10.2
33vaginitis10.2
34pleomorphic adenoma10.0
35uterus carcinoma in situ10.0
36small cell carcinoma10.0
37cervix small cell carcinoma10.0
38papillary hidradenoma10.0
39gallbladder squamous cell carcinoma10.0
40endometrial mucinous adenocarcinoma10.0
41ureter adenocarcinoma10.0
42renal pelvis adenocarcinoma10.0
43apocrine adenocarcinoma10.0
44appendix adenocarcinoma10.0
45bile duct adenocarcinoma10.0
46breast adenocarcinoma10.0
47breast carcinoma in situ10.0
48cervical mucinous adenocarcinoma10.0
49lupus erythematosus10.0
50ovary adenocarcinoma10.0

Graphical network of the top 20 diseases related to Adenocarcinoma in Situ:



Diseases related to adenocarcinoma in situ

Clinical Features for Adenocarcinoma in Situ

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Drugs & Therapeutics for Adenocarcinoma in Situ

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenocarcinoma in Situ

Drug clinical trials:

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Search NIH Clinical Center for Adenocarcinoma in Situ

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Genetic Tests for Adenocarcinoma in Situ

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Anatomical Context for Adenocarcinoma in Situ

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32MalaCards
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MalaCards organs/tissues related to Adenocarcinoma in Situ:

32
Cervix, Lung, Testes, Prostate, Colon, Breast, Lymph node, Thyroid, Uterus, Pancreas, Ovary, Appendix

Animal Models for Adenocarcinoma in Situ or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenocarcinoma in Situ:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.1PGR, MCM2, VIM
2MP:00053899.8WT1, CDKN2A, CDX2, CDKN1A, KRAS
3MP:00053799.7WT1, CDKN2A, CDX2, CDKN1A, KRAS
4MP:00053889.7ESR1, KRAS, MCM2, CDKN1A
5MP:00053699.7WT1, CDKN2A, CDKN1A, MCM2, ESR1
6MP:00107719.4PDYN, CDKN2A, CDKN1A, KRAS
7MP:00053769.4PDYN, CDX2, PGR, GP5, ESR1
8MP:00053819.2PDYN, CDKN2A, CDX2, CDKN1A, MCM2, KRAS
9MP:00020068.9ESR1, CDKN2A, CDX2, CDKN1A, MCM2, PGR
10MP:00053978.8CDKN2A, CDKN1A, MCM2, MCM7, PGR, KRAS
11MP:00053848.5VIM, WT1, CDKN2A, CDX2, CDKN1A, MCM2
12MP:00053788.2VIM, PDYN, WT1, CDKN2A, CDX2, CDKN1A
13MP:00107688.0CDX2, CDKN2A, WT1, VIM, CDKN1A, MCM2

Publications for Adenocarcinoma in Situ

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50PubMed
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Articles related to Adenocarcinoma in Situ:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
Tumour standardized uptake value on positron emission tomography is a novel predictor of adenocarcinoma in situ for c-Stage IA lung cancer patients with a part-solid nodule on thin-section CT scan. (24351509)
2013
2
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma. (23591077)
2013
3
Fluorescence in situ hybridization mapping of esophagectomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma. (21820152)
2012
4
Factors predicting the outcome of conservatively treated adenocarcinoma in situ of the uterine cervix: an analysis of 166 cases. (22188786)
2012
5
Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS). (22814813)
2012
6
Predictors of invasive adenocarcinoma after conization for cervical adenocarcinoma in situ. (22410327)
2012
7
Assessment of invasion in lung adenocarcinoma classification, including adenocarcinoma in situ and minimally invasive adenocarcinoma. (22214965)
2012
8
A case of adenocarcinoma in situ of the distal common bile duct diagnosed by percutaneous transhepatic cholangioscopy. (22707894)
2012
9
The two faces of cervical adenocarcinoma in situ. (20567153)
2010
10
A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. (19188825)
2009
11
Human papillomavirus-specific genotypes in cervical lesions of women referred for smears with atypical glandular cells or adenocarcinoma in situ. (19620946)
2009
12
Fortuitous detection of endocervical adenocarcinoma in situ: a report of 2 cases. (19691263)
2009
13
Adenocarcinoma in situ of the uterine cervix: a metaanalysis of 1278 patients evaluating the predictive value of conization margin status. (19019325)
2009
14
Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ. (18234283)
2008
15
Cold knife versus laser cone biopsy for adenocarcinoma in situ of the cervix--a comparison of management and outcome. (17506846)
2008
16
In situ and invasive components of mammary adenocarcinoma: comparison of Her-2/neu status. (17879632)
2007
17
Can adenocarcinoma in situ of the uterine cervix be predicted before cervical conization? (17250421)
2006
18
EGFR alterations in pancreatic ductal adenocarcinoma: a chromogenic in situ hybridization analysis based on tissue microarrays. (16795991)
2006
19
Adenocarcinoma in situ of the cervix in pregnancy. (15863176)
2005
20
Endometrial adenocarcinoma in situ in complex atypical hyperplasia: correlation with findings in subsequent hysterectomy specimen. (15306934)
2004
21
Detection of adenocarcinoma in situ of the cervix in Papanicolaou tests: comparison of diagnostic accuracy with other high-grade lesions. (14736290)
2004
22
Cervical cytology screening history of women diagnosed with adenocarcinoma in situ of the cervix: a case-control study. (15471249)
2004
23
Symposium part 4: Should pathologists diagnose endocervical preneoplastic lesions "less than" adenocarcinoma in situ?: Counterpoint. (12496693)
2003
24
Symposium part 3: Should pathologists diagnose endocervical preneoplastic lesions "less than" adenocarcinoma in situ?: Point. (12496692)
2003
25
Adenocarcinoma in situ of the cervix: sensitivity of detection by cervical smear: will cytologic screening for adenocarcinoma in situ reduce incidence rates for adenocarcinoma. (12478677)
2002
26
Cytologic and biopsy findings leading to conization in adenocarcinoma in situ of the cervix. (12151149)
2002
27
Invasive adenocarcinoma of the vagina following surgery for adenocarcinoma in situ of the cervix--recurrence or implantation? (11906556)
2001
28
Clinicopathological significance of core 2 beta1,6-N-acetylglucosaminyltransferase messenger RNA expressed in the pulmonary adenocarcinoma determined by in situ hybridization. (11280791)
2001
29
Adenocarcinoma in situ of the uterine cervix: an experience with 100 cases. (11063645)
2000
30
Recurrent invasive adenocarcinoma after hysterectomy for cervical adenocarcinoma in situ. (10785491)
2000
31
Adenocarcinoma in situ of the cervix: management and outcome. (10366458)
1999
32
Comparison of ThinPrep and Pap smear in relation to prediction of adenocarcinoma in situ. (9987454)
1999
33
Management of adenocarcinoma in situ of the cervix. (10627181)
1999
34
Adenocarcinoma in situ of the fallopian tube. A case report. (9850661)
1998
35
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions. (9439892)
1997
36
Chromosomal anomalies in stage D1 prostate adenocarcinoma primary tumors and lymph node metastases detected by fluorescence in situ hybridization. (8976257)
1997
37
Adenocarcinoma in situ of the uterine cervix progressing to invasive adenocarcinoma. (8798321)
1996
38
Invasive adenocarcinoma of the cervix following Lletz for adenocarcinoma in situ. (8631562)
1996
39
Monoclonal antibodies Ki-67 and MIB1 in the distinction of tuboendometrial metaplasia from endocervical adenocarcinoma and adenocarcinoma in situ in formalin-fixed material. (8600071)
1995
40
Invasive adenocarcinoma of the cervix following LLETZ (large loop excision of the transformation zone) for adenocarcinoma in situ. (7622120)
1995
41
Colposcopy of adenocarcinoma in situ and invasive adenocarcinoma of the cervix. (8332305)
1993
42
Colloid adenocarcinoma of the urethra associated with mucosal in situ carcinoma. (1326256)
1992
43
Demonstration of low frequency of human papillomavirus DNA in cervical adenocarcinoma and adenocarcinoma in situ by the polymerase chain reaction and in situ hybridization. (1848834)
1991
44
Comparative cytologic features of adenocarcinoma in situ of the uterine cervix. (1994620)
1991
45
The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia. (2298414)
1990
46
Cervical adenocarcinoma in situ. (3285263)
1988
47
Adenocarcinoma in situ of the cervix. Clinicopathologic observations of 11 cases. (3294196)
1988
48
The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri and related lesions. II. Microinvasive adenocarcinoma. (3376698)
1988
49
Adenocarcinoma in situ of the cervix: an underdiagnosed lesion. (7248903)
1981
50
Cyto- and histo-morphology of cervical adenocarcinoma in situ. (5520880)
1970

Genetic Variations for Adenocarcinoma in Situ

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Expression for genes affiliated with Adenocarcinoma in Situ

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma in Situ

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Pathways for genes affiliated with Adenocarcinoma in Situ

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53Reactome, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database
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Compounds for genes affiliated with Adenocarcinoma in Situ

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 28IUPHAR
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Compounds related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5CEACAM7, CDX2
2estrogen4410.5CEACAM7, PDYN
3cycloheximide4410.5CEACAM7
4resveratrol44 59 11 2413.4PGR
5Ethynodiol Diacetate1110.3PGR, ESR1
6ici 1643844410.3PGR, ESR1
7temozolomide44 1111.2CDKN1A, CDKN2A, VIM
8nomegestrol acetate4410.1TOP2A, ESR1, PGR
9Allylestrenol1110.1ESR1, PGR
10idoxifene4410.1PGR, ESR1
11taxane4410.1CDKN1A, PGR, ESR1
12Etonogestrel1110.0PGR, ESR1
13roscovitine4410.0IFI27, VIM, CDKN2A, CDKN1A
14vincristine44 49 1111.9WT1, VIM, TOP2A
15irinotecan44 49 1111.9KRAS, CEACAM5, CDKN1A, CDKN2A
16eb 108944 5910.8ESR1, IFI27, CDKN1A
17hematoxylin449.8KRT20, CDKN2A, VIM, CEACAM5
18mucicarmine449.8VIM, CEACAM5, CEACAM7, KRT20
19trastuzumab44 49 1111.8TOP2A, PGR, ESR1, IFI27
20docetaxel44 49 59 1112.7TOP2A, ESR1, CDKN1A, CDKN2A, PGR
21methotrexate44 49 1111.7PGR, CDKN2A, TOP2A, VIM, ESR1
22chloramphenicol44 2 1111.7TOP2A, CDKN2A, ESR1, VIM, WT1
23p00048449.7IFI27, CDKN1A
24retinoid449.7ESR1, PGR, CDKN1A, VIM, IFI27
25agar449.7CEACAM5, PGR, CDKN1A, CDKN2A, VIM
26b 723449.6KRT20, CEACAM5, CEACAM7, VIM, WT1
27cytarabine44 49 1111.6VIM, IFI27, CDKN1A, CDKN2A, TOP2A
28thymidylate449.6CDKN1A, VIM, CDKN2A, TOP2A, IFI27
29tamoxifen44 49 28 1112.6PGR, ESR1, CDKN1A, VIM, IFI27
30ribonucleic acid449.6CEACAM5, KRT20, PGR, WT1, PDYN
31actinomycin d449.5CEACAM7, ESR1, CDKN1A, CDKN2A, TOP2A, VIM
32vitamin d449.4WT1, ESR1, VIM, IFI27, KRAS, CDX2
33p002449.4CEACAM5, IFI27, TOP2A, KRAS
34adriamycin449.4PGR, CDKN1A, CDKN2A, TOP2A, VIM, CEACAM5
35steroid449.3ESR1, CDX2, TOP2A, PDYN, WT1, IFI27
365-aza-2deoxycytidine449.3TMEFF2, CDKN2A, ESR1, VIM, CDX2, PGR
37oligonucleotide449.3VIM, CDX2, CDKN1A, KRAS, CDKN2A, WT1
38paclitaxel44 49 1111.3CDKN1A, KRAS, IFI27, ESR1, PGR, CDKN2A
39genistein44 28 59 2 11 2414.2VIM, IFI27, ESR1, TOP2A, CDKN2A, CDKN1A
40gefitinib44 49 1111.2IFI27, VIM, CEACAM5, CEACAM7, ESR1, KRAS
41cisplatin44 49 59 1112.2CDKN2A, CDKN1A, CEACAM5, IFI27, TOP2A, KRAS
42testosterone44 59 11 2412.0VIM, ESR1, KRT20, PGR, IFI27, WT1
435fluorouracil449.0TOP2A, CEACAM5, ESR1, CEACAM7, KRAS, PGR
44thymidine44 249.9TOP2A, CDX2, CDKN1A, CEACAM7, WT1, CEACAM5
45retinoic acid44 249.7WT1, ESR1, TOP2A, KRAS, CDKN2A, PGR
46doxorubicin44 49 1110.4VIM, KRT20, PGR, CDKN2A, ESR1, WT1
47vegf448.2KRT20, PGR, CDKN1A, CDKN2A, TOP2A, WT1
48tyrosine448.0IFI27, CDKN1A, MCM7, KRAS, KRT20, CEACAM5
49progesterone44 59 28 11 2411.9PGR, VIM, IFI27, PDYN, WT1, TOP2A
50paraffin447.8PGR, IFI27, WT1, VIM, MCM2, CDKN2A

GO Terms for genes affiliated with Adenocarcinoma in Situ

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16Gene Ontology
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Cellular components related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MCM complexGO:04255510.0MCM7, MCM2
2nucleoplasmGO:0056548.0ESR1, WT1, TOP2A, POLR2G, CDKN2A, CDKN1A

Biological processes related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1G1/S transition of mitotic cell cycleGO:00008210.1MCM7, MCM2
2positive regulation of nitric-oxide synthase activityGO:05100010.1ESR1, KRAS
3DNA unwinding involved in DNA replicationGO:00626810.0MCM7, MCM2
4negative regulation of gene expressionGO:0106299.9CDKN1A, PGR, ESR1
5Ras protein signal transductionGO:0072659.8CDKN2A, CDKN1A, KRAS
6intermediate filament organizationGO:0451099.7KRT20, VIM
7mitotic cell cycleGO:0002789.3MCM7, MCM2, CDKN1A, CDKN2A, TOP2A

Molecular functions related to Adenocarcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.1CDKN1A, CDKN2A

Products for genes affiliated with Adenocarcinoma in Situ

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Sources for Adenocarcinoma in Situ

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet