MCID: ADN033

Adenocarcinoma of Lung, Somatic malady

Summaries for Adenocarcinoma of Lung, Somatic

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33OMIM, 22MalaCards
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MalaCards: Adenocarcinoma of Lung, Somatic, also known as adenocarcinoma, is related to lung adenocarcinoma and endometrial adenocarcinoma. An important gene associated with Adenocarcinoma of Lung, Somatic is BRAF (v-raf murine sarcoma viral oncogene homolog B1), and among its related pathways are Bladder cancer and ErbB4 Pathway. The drugs mitomycin and thiotepa and the compounds cetuximab and 17-(allylamino)-17-demethoxygeldanamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are respiratory system and integument.

OMIM: 211980

Aliases & Descriptions for Adenocarcinoma of Lung, Somatic

Sources:
43UMLS, 33OMIM
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adenocarcinoma of lung, somatic 33
adenocarcinoma 43

Related Diseases for Adenocarcinoma of Lung, Somatic

Sources:
13GeneCards, 14GeneDecks
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Diseases related to adenocarcinoma of lung, somatic by text searches and GeneDecks gene sharing:

(show top 50)    (show all 394)
idRelated DiseaseScoreTop Affiliating Genes
1lung adenocarcinoma36.9ERBB2, PARK2, BRAF
2endometrial adenocarcinoma34.9BRAF, ERBB2
3cervical adenocarcinoma32.8BRAF, ERBB2
4adenoma32.4ERBB2, PARK2, BRAF
5barrett's adenocarcinoma32.2ERBB2, BRAF
6cervicitis31.7ERBB2, PARK2, BRAF
7hypoxia30.8BRAF, PARK2, ERBB2
8gallbladder adenocarcinoma30.5BRAF, ERBB2
9pancreatic cancer27.8ERBB2, PARK2, BRAF
10ovarian carcinoma27.1ERBB2, PARK2, BRAF
11cervical endometrioid adenocarcinoma26.9BRAF, ERBB2
12non-small cell lung carcinoma26.8BRAF, ERBB2
13malignant pleural mesothelioma26.7BRAF, ERBB2
14gastrointestinal stromal tumor26.7BRAF, ERBB2
15renal cell carcinoma26.6ERBB2, PARK2, BRAF
16neuroendocrine tumor25.5BRAF, ERBB2
17papilloma25.4BRAF, PARK2, ERBB2
18nasopharyngitis25.3ERBB2, PARK2, BRAF
19kidney cancer25.2BRAF, PARK2
20glioblastoma23.9BRAF, PARK2, ERBB2
21adenocarcinoma15.2
22ampulla of vater carcinoma12.4ERBB2, BRAF
23familial pancreatic cancer12.4BRAF, ERBB2
24thyroid medullary carcinoma12.4BRAF, ERBB2
25mental retardation syndrome12.4BRAF, PARK2
26ovarian mucinous neoplasm12.4ERBB2, BRAF
27biliary tract cancer12.4BRAF, ERBB2
28lung occult squamous cell carcinoma12.4BRAF, ERBB2
29leprosy12.4ERBB2, PARK2
30gallbladder carcinoma12.3BRAF, ERBB2
31pancreatitis12.3
32urinary bladder cancer12.3BRAF, ERBB2
33nonencapsulated sclerosing carcinoma12.2BRAF, ERBB2
34stomach carcinoma12.2ERBB2, BRAF
35prostatitis12.1
36oculomotor apraxia cogan type12.0ERBB2, BRAF
37primary hyperoxaluria11.9BRAF, PARK2, ERBB2
38astrocytoma11.9ERBB2, PARK2, BRAF
39polycystic kidney disease11.7BRAF, ERBB2
40gastric adenocarcinoma11.6
41prostate adenocarcinoma11.6
42colon adenocarcinoma11.5
43carcinoma11.3
44esophagitis11.1
45pancreatic ductal adenocarcinoma10.9
46squamous cell carcinoma10.0
47barrett's esophagus9.8
48breast adenocarcinoma9.7
49clear cell adenocarcinoma9.5
50mucinous adenocarcinoma9.0

Graphical network of the top 20 diseases related to adenocarcinoma of lung, somatic:



Graphical network of diseases related to adenocarcinoma of lung, somatic

Clinical Features for Adenocarcinoma of Lung, Somatic

Sources:
33OMIM
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Clinical features from OMIM: 211980

Drugs & Therapeutics for Adenocarcinoma of Lung, Somatic

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for adenocarcinoma of lung, somatic

Drug clinical trials:

Search ClinicalTrials for adenocarcinoma of lung, somatic

Search NIH Clinical Center for adenocarcinoma of lung, somatic

Search CenterWatch for adenocarcinoma of lung, somatic

Inferred drug relations via UMLS/NDF-RT:

43 28 mitomycin, thiotepa

Genetic Tests for Adenocarcinoma of Lung, Somatic

Anatomical Context for Adenocarcinoma of Lung, Somatic

Sources:
22MalaCards
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MalaCards organs/tissues related to adenocarcinoma of lung, somatic:

22
Lung

Phenotypes for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
25MGI
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MGI Mouse Phenotypes related to adenocarcinoma of lung, somatic:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:00053888.5BRAF, ERBB2, PARK2
2integument phenotypeMP:00107718.5ERBB2, PARK2, BRAF
3muscle phenotypeMP:00053698.4PARK2, BRAF, ERBB2
4skeleton phenotypeMP:00053908.2ERBB2, PARK2, BRAF

Publications for genes affiliated with Adenocarcinoma of Lung, Somatic

Expression for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma of Lung, Somatic

Pathways for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
20KEGG, 36QIAGEN
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Compounds for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB
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Compounds related to adenocarcinoma of lung, somatic according to GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1cetuximab32 34 9 9 12.3BRAF, ERBB2
217-(allylamino)-17-demethoxygeldanamycin32 9.3BRAF, ERBB2
3irinotecan32 34 9 9 12.2ERBB2, BRAF
4guanine32 9 18 9 12.1PARK2, ERBB2
5p00232 9.0ERBB2, BRAF
6imatinib32 34 9 9 11.9ERBB2, BRAF
7geldanamycin32 9 9 10.8ERBB2, PARK2, BRAF
8paclitaxel32 34 9 9 11.8ERBB2, PARK2, BRAF
9valine32 8.7ERBB2, BRAF
10vegf32 8.7ERBB2, BRAF, PARK2
11alanine32 8.7ERBB2, PARK2, BRAF
12Adenosine triphosphate9 18 9 10.6PARK2, BRAF, ERBB2
13estrogen32 8.6PARK2, ERBB2, BRAF

GO Terms for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
12Gene Ontology
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Biological processes related to adenocarcinoma of lung, somatic according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3BRAF, PARK2

Sources for Adenocarcinoma of Lung, Somatic

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS