MCID: ADN033
MIFTS: 33

Adenocarcinoma of Lung, Somatic malady

Genetic diseases (common), Respiratory diseases categories

Summaries for Adenocarcinoma of Lung, Somatic

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MalaCards based summary: Adenocarcinoma of Lung, Somatic is related to gastric cancer, somatic and malignant mixed mullerian tumor. An important gene associated with Adenocarcinoma of Lung, Somatic is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are MAPK Pathway and IL-6 Signaling Pathway. The compounds 17-(allylamino)-17-demethoxygeldanamycin and panitumumab have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are muscle and tumorigenesis.

Description from OMIM:46 211980

Aliases & Classifications for Adenocarcinoma of Lung, Somatic

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Adenocarcinoma of Lung, Somatic, Aliases & Descriptions:

Name: Adenocarcinoma of Lung, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


Related Diseases for Adenocarcinoma of Lung, Somatic

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Diseases related to Adenocarcinoma of Lung, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 36)
idRelated DiseaseScoreTop Affiliating Genes
1gastric cancer, somatic10.2KRAS, ERBB2
2malignant mixed mullerian tumor10.2KRAS, ERBB2
3kidney rhabdoid cancer10.2BRAF, PARK2
4cardiofaciocutaneous syndrome10.2BRAF, KRAS
5costello syndrome10.2KRAS, BRAF
6large cell carcinoma10.2KRAS, ERBB2
7factor vii deficiency10.2ERBB2, KRAS
8papillary carcinoma10.2ERBB2, BRAF
9cystadenoma10.1KRAS, BRAF
10breast cancer, somatic10.1KRAS, SLC22A18
11lynch syndrome10.1KRAS, BRAF
12noonan syndrome10.1KRAS, BRAF
13seminoma10.1KRAS, BRAF
14cholangiocarcinoma10.0ERBB2, BRAF, KRAS
15autoimmune thyroiditis10.0FASLG, BRAF
16endometrial carcinoma10.0KRAS, BRAF, ERBB2
17retinoblastoma10.0PARK2, ERBB2, KRAS
18cervical cancer9.9KRAS, BRAF, PPP2R1B
19non-small cell lung carcinoma9.9BRAF, ERBB2, KRAS
20thyroid hurthle cell carcinoma9.9FASLG, BRAF
21familial adenomatous polyposis9.9KRAS, BRAF
22gastric adenocarcinoma9.8FASLG, ERBB2, KRAS
23lung adenocarcinoma9.8KRAS, ERBB2, PARK2, BRAF
24kidney cancer9.8BRAF, PARK2, FASLG
25colon adenocarcinoma9.8FASLG, KRAS
26breast cancer9.8PPP2R1B, ERBB2, KRAS
27lung cancer9.8BRAF, PPP2R1B, ERBB2, KRAS
28colonic benign neoplasm9.7FASLG, BRAF, KRAS
29colorectal cancer9.7ERBB2, FASLG, BRAF, KRAS
30ovarian cancer9.7ERBB2, BRAF, FASLG, KRAS
31pancreatic cancer9.7BRAF, FASLG, ERBB2, KRAS
32stomach cancer9.6BRAF, FASLG, ERBB2, KRAS
33burkitt's lymphoma9.6FASLG, KRAS, PARK2
34adenocarcinoma9.6FASLG, KRAS, ERBB2, BRAF
35liver cancer9.6PARK2, FASLG, KRAS, PPP2R1B
36melanoma9.5KRAS, PPP2R1B, BRAF, FASLG

Graphical network of the top 20 diseases related to Adenocarcinoma of Lung, Somatic:



Diseases related to adenocarcinoma of lung, somatic

Symptoms for Adenocarcinoma of Lung, Somatic

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Clinical features from OMIM:

211980

Drugs & Therapeutics for Adenocarcinoma of Lung, Somatic

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Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma of Lung, Somatic

Search NIH Clinical Center for Adenocarcinoma of Lung, Somatic

Genetic Tests for Adenocarcinoma of Lung, Somatic

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Anatomical Context for Adenocarcinoma of Lung, Somatic

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MalaCards organs/tissues related to Adenocarcinoma of Lung, Somatic:

32
Lung

Animal Models for Adenocarcinoma of Lung, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Adenocarcinoma of Lung, Somatic:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8BRAF, PARK2, ERBB2, KRAS
2MP:00020068.4BRAF, FASLG, ERBB2, KRAS
3MP:00053908.4BRAF, PARK2, FASLG, ERBB2
4MP:00053818.4KRAS, ERBB2, FASLG, BRAF
5MP:00053798.3KRAS, ERBB2, FASLG, BRAF
6MP:00053898.2KRAS, ERBB2, FASLG, BRAF
7MP:00053888.1KRAS, ERBB2, FASLG, PARK2, BRAF
8MP:00107718.0BRAF, PARK2, FASLG, ERBB2, KRAS
9MP:00053858.0KRAS, ERBB2, FASLG, PARK2, BRAF
10MP:00053848.0BRAF, PARK2, FASLG, ERBB2, KRAS
11MP:00036317.9BRAF, PARK2, FASLG, ERBB2, KRAS
12MP:00028737.9BRAF, FASLG, ERBB2, KRAS
13MP:00053767.7KRAS, ERBB2, FASLG, PARK2, BRAF

Publications for Adenocarcinoma of Lung, Somatic

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Variations for Adenocarcinoma of Lung, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma of Lung, Somatic:

63
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Adenocarcinoma of Lung, Somatic:

7
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Adenocarcinoma of Lung, Somatic

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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma of Lung, Somatic

Search GEO for disease gene expression data for Adenocarcinoma of Lung, Somatic.

Pathways for genes affiliated with Adenocarcinoma of Lung, Somatic

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Pathways related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6BRAF, ERBB2
29.6ERBB2, PPP2R1B
39.5KRAS, ERBB2
4
Show member pathways
9.5KRAS, ERBB2
5
Show member pathways
9.4BRAF, KRAS
69.4KRAS, BRAF
79.4KRAS, BRAF
8
Show member pathways
9.4KRAS, BRAF
9
Show member pathways
9.4KRAS, BRAF
10
Show member pathways
9.4KRAS, BRAF
11
Show member pathways
9.4KRAS, BRAF
12
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway37
9.4KRAS, BRAF
139.4BRAF, KRAS
149.4KRAS, BRAF
15
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.2FASLG, BRAF
16
Show member pathways
9.1PPP2R1B, BRAF, ERBB2
17
Show member pathways
9.1ERBB2, BRAF, PPP2R1B
18
Show member pathways
9.1ERBB2, BRAF, PPP2R1B
19
Show member pathways
9.1ERBB2, BRAF, PPP2R1B
20
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0BRAF, ERBB2, KRAS
21
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
9.0KRAS, ERBB2, BRAF
22
Show member pathways
Signaling Pathways in Glioblastoma37
9.0KRAS, ERBB2, BRAF
23
Show member pathways
9.0KRAS, ERBB2, BRAF
24
Show member pathways
Signal transduction PTEN pathway59
9.0KRAS, ERBB2, BRAF
25
Show member pathways
8.9PPP2R1B, BRAF, KRAS
268.9PPP2R1B, BRAF, KRAS
278.9PPP2R1B, BRAF, KRAS
28
Show member pathways
8.9KRAS, BRAF, PPP2R1B
29
Show member pathways
8.9KRAS, BRAF, PPP2R1B
30
Show member pathways
8.9KRAS, BRAF, PPP2R1B
31
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.8PPP2R1B, FASLG, ERBB2
32
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I59
8.7FASLG, PARK2, PPP2R1B
338.7KRAS, ERBB2, FASLG
34
Show member pathways
8.6BRAF, FASLG, KRAS
35
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.6BRAF, FASLG, KRAS
36
Show member pathways
Immune response CD16 signaling in NK cells59
8.6BRAF, FASLG, KRAS
37
Show member pathways
MAPK signaling pathway37
8.6KRAS, FASLG, BRAF
38
Show member pathways
8.5PPP2R1B, PARK2, ERBB2, KRAS
398.5PPP2R1B, FASLG, KRAS
40
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5KRAS, FASLG, PPP2R1B
41
Show member pathways
8.5PPP2R1B, BRAF, ERBB2, KRAS
42
Show member pathways
8.5PPP2R1B, BRAF, ERBB2, KRAS
43
Show member pathways
8.3ERBB2, FASLG, BRAF, PPP2R1B
448.2KRAS, ERBB2, FASLG, BRAF
458.2KRAS, ERBB2, FASLG, BRAF
46
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.2KRAS, ERBB2, FASLG, BRAF

Compounds for genes affiliated with Adenocarcinoma of Lung, Somatic

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Compounds related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
117-(allylamino)-17-demethoxygeldanamycin4410.0BRAF, ERBB2
2panitumumab44 50 1211.8KRAS, BRAF
3erlotinib44 50 1211.8KRAS, ERBB2
4regorafenib50 1210.8KRAS, BRAF
5o6-methylguanine449.8KRAS, BRAF
6crcs449.8KRAS, BRAF
7oxaliplatin44 50 1211.7ERBB2, KRAS
8geldanamycin44 50 60 1212.7ERBB2, PARK2, BRAF
9topotecan44 1210.6ERBB2, FASLG
10gefitinib44 50 1211.6KRAS, ERBB2
11suberoylanilide hydroxamic acid449.6ERBB2, FASLG
12mitoxantrone44 50 1211.6ERBB2, FASLG
13ganciclovir44 1210.5ERBB2, FASLG
14depsipeptide449.5FASLG, BRAF
154-hydroxytamoxifen449.5ERBB2, FASLG
16ifn-alpha449.5FASLG, PARK2
17bortezomib44 50 1211.5FASLG, ERBB2
18cetuximab44 50 1211.5KRAS, ERBB2, BRAF
19ag 1478449.5ERBB2, FASLG
20irinotecan44 50 1211.4BRAF, ERBB2, KRAS
21p002449.4KRAS, ERBB2, BRAF
22valine449.4KRAS, ERBB2, BRAF
23calyculin a44 60 1211.4PPP2R1B, FASLG
24tetracycline44 1210.3FASLG, ERBB2
25phosphoinositide449.3KRAS, PARK2, BRAF
26gtp44 2910.3BRAF, PARK2, KRAS
27carboplatin44 50 1211.3ERBB2, FASLG
28biotin44 25 1211.3ERBB2, FASLG
29agar449.2BRAF, FASLG, ERBB2
30leucovorin44 50 1211.1KRAS, ERBB2, FASLG
315fluorouracil449.0KRAS, ERBB2, FASLG
32progesterone44 29 60 25 1213.0ERBB2, FASLG, BRAF
33lactacystin448.9FASLG, PARK2
34alanine448.8BRAF, PARK2, FASLG, ERBB2
35testosterone44 60 25 1211.8PARK2, FASLG, ERBB2
36aspartate448.7PPP2R1B, BRAF, FASLG, ERBB2
37h2o2448.7PARK2, FASLG, ERBB2, KRAS
38imatinib44 50 1210.7BRAF, FASLG, ERBB2, KRAS
39rapamycin448.6BRAF, FASLG, ERBB2, KRAS
40ly294002448.6BRAF, FASLG, ERBB2, KRAS
41wortmannin448.6BRAF, FASLG, ERBB2, KRAS
42paraffin448.6KRAS, ERBB2, FASLG, BRAF
43cisplatin44 50 60 1211.6BRAF, FASLG, ERBB2, KRAS
44phosphatidylinositol448.6BRAF, FASLG, ERBB2, KRAS
45oligonucleotide448.6KRAS, FASLG, PARK2, BRAF
46paclitaxel44 50 1210.2KRAS, ERBB2, FASLG, PARK2, BRAF
47vegf448.2BRAF, PARK2, FASLG, ERBB2, KRAS
48estrogen448.2KRAS, ERBB2, FASLG, PARK2, BRAF
49tyrosine448.2BRAF, PARK2, FASLG, ERBB2, KRAS
50serine447.7PPP2R1B, BRAF, PARK2, FASLG, ERBB2, KRAS

GO Terms for genes affiliated with Adenocarcinoma of Lung, Somatic

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Cellular components related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484718.9ERBB2, FASLG, PARK2

Biological processes related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein phosphorylationGO:0019349.5KRAS, ERBB2
2positive regulation of MAP kinase activityGO:0434069.4KRAS, ERBB2
3negative regulation of neuron apoptotic processGO:0435249.1KRAS, PARK2, BRAF
4activation of MAPKK activityGO:0001869.1KRAS, BRAF
5fibroblast growth factor receptor signaling pathwayGO:0085439.1KRAS, ERBB2, BRAF
6neurotrophin TRK receptor signaling pathwayGO:0480119.0BRAF, ERBB2, KRAS

Molecular functions related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.2ERBB2, PARK2, BRAF
2protein bindingGO:0055157.0KRAS, ERBB2, FASLG, PARK2, BRAF, PPP2R1B

Products for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources for Adenocarcinoma of Lung, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet