MCID: ADN033
MIFTS: 27

Adenocarcinoma of Lung, Somatic malady

Genetic diseases (common), Respiratory diseases categories
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Summaries for Adenocarcinoma of Lung, Somatic

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47OMIM, 33MalaCards
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MalaCards: Adenocarcinoma of Lung, Somatic is related to lung cancer and papillary carcinoma. An important gene associated with Adenocarcinoma of Lung, Somatic is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are Proteoglycans in cancer and Focal adhesion. The compounds cetuximab and 17-(allylamino)-17-demethoxygeldanamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are respiratory system and integument.

Description from OMIM:47 211980

Aliases & Classifications for Adenocarcinoma of Lung, Somatic

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


Aliases & Descriptions:

adenocarcinoma of lung, somatic 47


Related Diseases for Adenocarcinoma of Lung, Somatic

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17GeneCards, 18GeneDecks
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Diseases related to Adenocarcinoma of Lung, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer10.1ERBB2
2papillary carcinoma10.0BRAF, ERBB2
3cholangiocarcinoma10.0ERBB2, BRAF
4non-small cell lung carcinoma10.0BRAF, ERBB2
5kidney rhabdoid cancer10.0PARK2, BRAF
6endometrial carcinoma10.0ERBB2, BRAF
7colorectal cancer10.0ERBB2, BRAF
8mental retardation9.9PARK2, BRAF
9stomach cancer9.9BRAF, ERBB2
10ovarian cancer9.9ERBB2, PARK2, BRAF
11lung adenocarcinoma9.9BRAF, ERBB2, PARK2
12breast cancer9.9SLC22A18, PARK2, ERBB2, BRAF

Graphical network of diseases related to Adenocarcinoma of Lung, Somatic:



Diseases related to adenocarcinoma of lung, somatic

Symptoms for Adenocarcinoma of Lung, Somatic

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47OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Adenocarcinoma of Lung, Somatic

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma of Lung, Somatic

Search NIH Clinical Center for Adenocarcinoma of Lung, Somatic

Genetic Tests for Adenocarcinoma of Lung, Somatic

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Anatomical Context for Adenocarcinoma of Lung, Somatic

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33MalaCards
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MalaCards organs/tissues related to Adenocarcinoma of Lung, Somatic:

33
Lung

Animal Models for Adenocarcinoma of Lung, Somatic or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Adenocarcinoma of Lung, Somatic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5ERBB2, PARK2, BRAF
2MP:00107718.5ERBB2, PARK2, BRAF
3MP:00053698.4ERBB2, PARK2, BRAF
4MP:00053908.2BRAF, PARK2, ERBB2

Publications for Adenocarcinoma of Lung, Somatic

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Variations for Adenocarcinoma of Lung, Somatic

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma of Lung, Somatic:

64
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Adenocarcinoma of Lung, Somatic:

1
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Adenocarcinoma of Lung, Somatic

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma of Lung, Somatic

Search GEO for disease gene expression data for Adenocarcinoma of Lung, Somatic.

Pathways for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
50PathCards, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 51PharmGKB, 61Tocris Bioscience
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Pathways related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ERBB2, BRAF
2
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
9.1BRAF, ERBB2
3
Show member pathways
9.1ERBB2, BRAF
4
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1ERBB2, BRAF
5
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.1ERBB2, BRAF
6
Show member pathways
Signaling Pathways in Glioblastoma38
9.1BRAF, ERBB2
7
Show member pathways
9.1ERBB2, BRAF
8
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.1BRAF, ERBB2
9
Show member pathways
Signal transduction PTEN pathway60
9.1ERBB2, BRAF
10
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.1ERBB2, BRAF
11
Show member pathways
9.1ERBB2, BRAF

Compounds for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience
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Compounds related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1cetuximab45 51 1111.4ERBB2, BRAF
217-(allylamino)-17-demethoxygeldanamycin459.4ERBB2, BRAF
3guanine45 24 1111.4ERBB2, PARK2
4irinotecan45 51 1111.4ERBB2, BRAF
5p002459.3ERBB2, BRAF
6imatinib45 51 1111.3ERBB2, BRAF
7valine459.2BRAF, ERBB2
8agar459.1BRAF, ERBB2
9rapamycin459.1ERBB2, BRAF
10geldanamycin45 51 61 1111.8ERBB2, PARK2, BRAF
11paclitaxel45 51 1110.8BRAF, PARK2, ERBB2
12vegf458.8BRAF, PARK2, ERBB2
13alanine458.8BRAF, PARK2, ERBB2
14Adenosine triphosphate24 119.7ERBB2, PARK2, BRAF
15estrogen458.7BRAF, PARK2, ERBB2
16serine458.4ERBB2, PARK2, BRAF
17tyrosine458.2ERBB2, PARK2, BRAF

GO Terms for genes affiliated with Adenocarcinoma of Lung, Somatic

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16Gene Ontology
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Cellular components related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.4SLC22A18, ERBB2

Biological processes related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:0480119.1ERBB2, BRAF
2negative regulation of neuron apoptotic processGO:0435248.9PARK2, BRAF
3fibroblast growth factor receptor signaling pathwayGO:0085438.8ERBB2, BRAF

Molecular functions related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.3SLC22A18, PARK2
2identical protein bindingGO:0428028.2ERBB2, PARK2, BRAF

Products for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources for Adenocarcinoma of Lung, Somatic

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet