MCID: ADN033
MIFTS: 27

Adenocarcinoma of Lung, Somatic malady

Genetic diseases (common), Respiratory diseases categories

Summaries for Adenocarcinoma of Lung, Somatic

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48OMIM, 34MalaCards
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MalaCards: Adenocarcinoma of Lung, Somatic is related to lung cancer and papillary carcinoma. An important gene associated with Adenocarcinoma of Lung, Somatic is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are Proteoglycans in cancer and Focal adhesion. The compounds cetuximab and 17-(allylamino)-17-demethoxygeldanamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are respiratory system and integument.

Description from OMIM:48 211980

Aliases & Classifications for Adenocarcinoma of Lung, Somatic

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Sources:
48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


Aliases & Descriptions:

adenocarcinoma of lung, somatic 48


Related Diseases for Adenocarcinoma of Lung, Somatic

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Adenocarcinoma of Lung, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer10.1ERBB2
2papillary carcinoma10.0BRAF, ERBB2
3cholangiocarcinoma10.0ERBB2, BRAF
4non-small cell lung carcinoma10.0BRAF, ERBB2
5kidney rhabdoid cancer10.0PARK2, BRAF
6endometrial carcinoma10.0ERBB2, BRAF
7colorectal cancer10.0ERBB2, BRAF
8mental retardation9.9PARK2, BRAF
9stomach cancer9.9BRAF, ERBB2
10ovarian cancer9.9ERBB2, PARK2, BRAF
11lung adenocarcinoma9.9BRAF, ERBB2, PARK2
12breast cancer9.9SLC22A18, PARK2, ERBB2, BRAF

Graphical network of diseases related to Adenocarcinoma of Lung, Somatic:



Diseases related to adenocarcinoma of lung, somatic

Symptoms for Adenocarcinoma of Lung, Somatic

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Sources:
48OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Adenocarcinoma of Lung, Somatic

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenocarcinoma of Lung, Somatic

Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma of Lung, Somatic

Search NIH Clinical Center for Adenocarcinoma of Lung, Somatic

Search CenterWatch for Adenocarcinoma of Lung, Somatic

Genetic Tests for Adenocarcinoma of Lung, Somatic

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Anatomical Context for Adenocarcinoma of Lung, Somatic

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Sources:
34MalaCards
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MalaCards organs/tissues related to Adenocarcinoma of Lung, Somatic:

34
Lung

Animal Models for Adenocarcinoma of Lung, Somatic or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Adenocarcinoma of Lung, Somatic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5ERBB2, PARK2, BRAF
2MP:00107718.5ERBB2, PARK2, BRAF
3MP:00053698.4ERBB2, PARK2, BRAF
4MP:00053908.2BRAF, PARK2, ERBB2

Publications for Adenocarcinoma of Lung, Somatic

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Variations for Adenocarcinoma of Lung, Somatic

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma of Lung, Somatic:

65
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Adenocarcinoma of Lung, Somatic:

1
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenic, risk factorrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma of Lung, Somatic

Search GEO for disease gene expression data for Adenocarcinoma of Lung, Somatic.

Pathways for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
51PathCards, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 52PharmGKB, 62Tocris Bioscience
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Pathways related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ERBB2, BRAF
2
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.1BRAF, ERBB2
3
Show member pathways
9.1ERBB2, BRAF
4
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.1ERBB2, BRAF
5
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.1ERBB2, BRAF
6
Show member pathways
Signaling Pathways in Glioblastoma39
9.1BRAF, ERBB2
7
Show member pathways
9.1ERBB2, BRAF
8
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.1BRAF, ERBB2
9
Show member pathways
Signal transduction PTEN pathway61
9.1ERBB2, BRAF
10
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.1ERBB2, BRAF
11
Show member pathways
9.1ERBB2, BRAF

Compounds for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1cetuximab46 52 1211.4ERBB2, BRAF
217-(allylamino)-17-demethoxygeldanamycin469.4ERBB2, BRAF
3guanine46 25 1211.4ERBB2, PARK2
4irinotecan46 52 1211.4ERBB2, BRAF
5p002469.3ERBB2, BRAF
6imatinib46 52 1211.3ERBB2, BRAF
7valine469.2BRAF, ERBB2
8agar469.1BRAF, ERBB2
9rapamycin469.1ERBB2, BRAF
10geldanamycin46 52 62 1211.8ERBB2, PARK2, BRAF
11paclitaxel46 52 1210.8BRAF, PARK2, ERBB2
12vegf468.8BRAF, PARK2, ERBB2
13alanine468.8BRAF, PARK2, ERBB2
14Adenosine triphosphate25 129.7ERBB2, PARK2, BRAF
15estrogen468.7BRAF, PARK2, ERBB2
16serine468.4ERBB2, PARK2, BRAF
17tyrosine468.2ERBB2, PARK2, BRAF

GO Terms for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
17Gene Ontology
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Cellular components related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.4SLC22A18, ERBB2

Biological processes related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:0480119.1ERBB2, BRAF
2negative regulation of neuron apoptotic processGO:0435248.9PARK2, BRAF
3fibroblast growth factor receptor signaling pathwayGO:0085438.8ERBB2, BRAF

Molecular functions related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.3SLC22A18, PARK2
2identical protein bindingGO:0428028.2ERBB2, PARK2, BRAF

Products for genes affiliated with Adenocarcinoma of Lung, Somatic

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  • Antibodies
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Sources for Adenocarcinoma of Lung, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet