MCID: ADN033
MIFTS: 17

Adenocarcinoma of Lung, Somatic malady

Respiratory category

Summaries for Adenocarcinoma of Lung, Somatic

Sources:
47OMIM, 33MalaCards
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MalaCards: Adenocarcinoma of Lung, Somatic is related to papilloma and astrocytoma. An important gene associated with Adenocarcinoma of Lung, Somatic is BRAF (v-raf murine sarcoma viral oncogene homolog B), and among its related pathways are Immune System and Proteoglycans in cancer. The compounds cetuximab and 17-(allylamino)-17-demethoxygeldanamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are respiratory system and integument.

Description from OMIM:47 211980

Aliases & Classifications for Adenocarcinoma of Lung, Somatic

Sources:
47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

adenocarcinoma of lung, somatic 47


Related Diseases for Adenocarcinoma of Lung, Somatic

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Adenocarcinoma of Lung, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma10.0PARK2
2astrocytoma10.0PARK2
3adenoma10.0BRAF
4biliary tract cancer10.0ERBB2
5glioblastoma multiforme10.0ERBB2
6kidney rhabdoid cancer10.0PARK2, BRAF
7papillary carcinoma10.0ERBB2, BRAF
8non-small cell lung carcinoma10.0BRAF, ERBB2
9endometrial carcinoma10.0BRAF, ERBB2
10stomach cancer10.0ERBB2, BRAF
11pancreatic cancer10.0ERBB2, BRAF
12lung adenocarcinoma10.0ERBB2, PARK2, BRAF
13ovarian cancer10.0BRAF, PARK2, ERBB2

Graphical network of diseases related to Adenocarcinoma of Lung, Somatic:



Diseases related to adenocarcinoma of lung, somatic

Clinical Features for Adenocarcinoma of Lung, Somatic

Sources:
47OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Adenocarcinoma of Lung, Somatic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenocarcinoma of Lung, Somatic

Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma of Lung, Somatic

Search NIH Clinical Center for Adenocarcinoma of Lung, Somatic

Search CenterWatch for Adenocarcinoma of Lung, Somatic

Genetic Tests for Adenocarcinoma of Lung, Somatic

Anatomical Context for Adenocarcinoma of Lung, Somatic

Sources:
33MalaCards
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MalaCards organs/tissues related to Adenocarcinoma of Lung, Somatic:

33
Lung

Animal Models for Adenocarcinoma of Lung, Somatic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Adenocarcinoma of Lung, Somatic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5ERBB2, PARK2, BRAF
2MP:00107718.5ERBB2, PARK2, BRAF
3MP:00053698.4ERBB2, PARK2, BRAF
4MP:00053908.2BRAF, PARK2, ERBB2

Publications for Adenocarcinoma of Lung, Somatic

Genetic Variations for Adenocarcinoma of Lung, Somatic

Expression for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma of Lung, Somatic

Search GEO for disease gene expression data for Adenocarcinoma of Lung, Somatic.

Pathways for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 50PharmGKB, 52QIAGEN
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Compounds for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
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Compounds related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1cetuximab45 50 1111.3ERBB2, BRAF
217-(allylamino)-17-demethoxygeldanamycin459.3ERBB2, BRAF
3irinotecan45 50 1111.2BRAF, ERBB2
4p002459.2BRAF, ERBB2
5imatinib45 50 1111.1ERBB2, BRAF
6guanine45 11 2411.1ERBB2, PARK2
7valine459.1BRAF, ERBB2
8geldanamycin45 50 60 1111.8ERBB2, PARK2, BRAF
9paclitaxel45 50 1110.8PARK2, ERBB2, BRAF
10vegf458.8ERBB2, PARK2, BRAF
11alanine458.7BRAF, PARK2, ERBB2
12agar458.7ERBB2, BRAF
13Adenosine triphosphate11 249.7PARK2, ERBB2, BRAF
14estrogen458.7ERBB2, PARK2, BRAF
15tyrosine458.5ERBB2, BRAF, PARK2
16serine458.4ERBB2, PARK2, BRAF

GO Terms for genes affiliated with Adenocarcinoma of Lung, Somatic

Sources:
16Gene Ontology
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Biological processes related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:0480119.0ERBB2, BRAF
2fibroblast growth factor receptor signaling pathwayGO:0085438.7ERBB2, BRAF

Molecular functions related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.5ERBB2, PARK2, BRAF

Products for genes affiliated with Adenocarcinoma of Lung, Somatic

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenocarcinoma of Lung, Somatic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet