MCID: ADN033
MIFTS: 25

Adenocarcinoma of Lung, Somatic malady

Respiratory diseases category

Summaries for Adenocarcinoma of Lung, Somatic

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46OMIM, 32MalaCards
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MalaCards: Adenocarcinoma of Lung, Somatic is related to papilloma and astrocytoma. An important gene associated with Adenocarcinoma of Lung, Somatic is BRAF (v-raf murine sarcoma viral oncogene homolog B), and among its related pathways are Immune System and Proteoglycans in cancer. The compounds cetuximab and 17-(allylamino)-17-demethoxygeldanamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are respiratory system and integument.

Description from OMIM:46 211980

Aliases & Classifications for Adenocarcinoma of Lung, Somatic

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Sources:
46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

adenocarcinoma of lung, somatic 46


Related Diseases for Adenocarcinoma of Lung, Somatic

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17GeneCards, 18GeneDecks
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Diseases related to Adenocarcinoma of Lung, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma10.0PARK2
2astrocytoma10.0PARK2
3adenoma10.0BRAF
4biliary tract neoplasm10.0ERBB2
5glioblastoma multiforme10.0ERBB2
6kidney rhabdoid cancer10.0PARK2, BRAF
7papillary carcinoma10.0ERBB2, BRAF
8non-small cell lung carcinoma10.0BRAF, ERBB2
9endometrial carcinoma10.0ERBB2, BRAF
10stomach cancer10.0ERBB2, BRAF
11pancreatic cancer10.0ERBB2, BRAF
12lung adenocarcinoma10.0ERBB2, PARK2, BRAF
13ovarian cancer10.0BRAF, PARK2, ERBB2

Graphical network of diseases related to Adenocarcinoma of Lung, Somatic:



Diseases related to adenocarcinoma of lung, somatic

Clinical Features for Adenocarcinoma of Lung, Somatic

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Sources:
46OMIM
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Clinical features from OMIM:

211980

Drugs & Therapeutics for Adenocarcinoma of Lung, Somatic

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenocarcinoma of Lung, Somatic

Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma of Lung, Somatic

Search NIH Clinical Center for Adenocarcinoma of Lung, Somatic

Search CenterWatch for Adenocarcinoma of Lung, Somatic

Genetic Tests for Adenocarcinoma of Lung, Somatic

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Anatomical Context for Adenocarcinoma of Lung, Somatic

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Sources:
32MalaCards
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MalaCards organs/tissues related to Adenocarcinoma of Lung, Somatic:

32
Lung

Animal Models for Adenocarcinoma of Lung, Somatic or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenocarcinoma of Lung, Somatic:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5BRAF, PARK2, ERBB2
2MP:00107718.5BRAF, PARK2, ERBB2
3MP:00053698.4BRAF, PARK2, ERBB2
4MP:00053908.2BRAF, PARK2, ERBB2

Publications for Adenocarcinoma of Lung, Somatic

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Genetic Variations for Adenocarcinoma of Lung, Somatic

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Adenocarcinoma of Lung, Somatic:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Expression for genes affiliated with Adenocarcinoma of Lung, Somatic

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma of Lung, Somatic

Search GEO for disease gene expression data for Adenocarcinoma of Lung, Somatic.

Pathways for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 51QIAGEN
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Compounds for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1cetuximab44 49 1111.3ERBB2, BRAF
217-(allylamino)-17-demethoxygeldanamycin449.3ERBB2, BRAF
3irinotecan44 49 1111.2BRAF, ERBB2
4p002449.2BRAF, ERBB2
5imatinib44 49 1111.1ERBB2, BRAF
6guanine44 11 2411.1PARK2, ERBB2
7valine449.1ERBB2, BRAF
8geldanamycin44 49 59 1111.8ERBB2, PARK2, BRAF
9paclitaxel44 49 1110.8BRAF, PARK2, ERBB2
10vegf448.8BRAF, PARK2, ERBB2
11alanine448.7ERBB2, PARK2, BRAF
12agar448.7ERBB2, BRAF
13Adenosine triphosphate11 249.7ERBB2, PARK2, BRAF
14estrogen448.7ERBB2, PARK2, BRAF
15tyrosine448.5ERBB2, PARK2, BRAF
16serine448.4ERBB2, PARK2, BRAF

GO Terms for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources:
16Gene Ontology
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Biological processes related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotrophin TRK receptor signaling pathwayGO:0480119.0ERBB2, BRAF
2fibroblast growth factor receptor signaling pathwayGO:0085438.7ERBB2, BRAF

Molecular functions related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.5ERBB2, PARK2, BRAF

Products for genes affiliated with Adenocarcinoma of Lung, Somatic

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  • Antibodies
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  • Antibodies

Sources for Adenocarcinoma of Lung, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet