MCID: ADN033
MIFTS: 33

Adenocarcinoma of Lung, Somatic malady

Genetic diseases (common), Respiratory diseases categories
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Summaries for Adenocarcinoma of Lung, Somatic

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MalaCards based summary: Adenocarcinoma of Lung, Somatic is related to gastric cancer, somatic and kidney rhabdoid cancer. An important gene associated with Adenocarcinoma of Lung, Somatic is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are MAPK Pathway and IL-6 Signaling Pathway. The compounds 17-(allylamino)-17-demethoxygeldanamycin and panitumumab have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are muscle and tumorigenesis.

Description from OMIM:46 211980

Aliases & Classifications for Adenocarcinoma of Lung, Somatic

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Adenocarcinoma of Lung, Somatic, Aliases & Descriptions:

Name: Adenocarcinoma of Lung, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Respiratory diseases


Related Diseases for Adenocarcinoma of Lung, Somatic

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Diseases related to Adenocarcinoma of Lung, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 36)
idRelated DiseaseScoreTop Affiliating Genes
1gastric cancer, somatic10.2KRAS, ERBB2
2kidney rhabdoid cancer10.2PARK2, BRAF
3malignant mixed mullerian tumor10.2ERBB2, KRAS
4cardiofaciocutaneous syndrome10.2KRAS, BRAF
5costello syndrome10.2KRAS, BRAF
6large cell carcinoma10.2ERBB2, KRAS
7factor vii deficiency10.2KRAS, ERBB2
8papillary carcinoma10.2ERBB2, BRAF
9cystadenoma10.1KRAS, BRAF
10breast cancer, somatic10.1KRAS, SLC22A18
11lynch syndrome10.1BRAF, KRAS
12noonan syndrome10.1BRAF, KRAS
13seminoma10.1BRAF, KRAS
14cholangiocarcinoma10.0BRAF, ERBB2, KRAS
15autoimmune thyroiditis10.0BRAF, FASLG
16endometrial carcinoma10.0BRAF, ERBB2, KRAS
17retinoblastoma10.0PARK2, ERBB2, KRAS
18cervical cancer9.9PPP2R1B, BRAF, KRAS
19non-small cell lung carcinoma9.9BRAF, ERBB2, KRAS
20thyroid hurthle cell carcinoma9.9BRAF, FASLG
21familial adenomatous polyposis9.9KRAS, BRAF
22gastric adenocarcinoma9.8FASLG, ERBB2, KRAS
23kidney cancer9.8BRAF, PARK2, FASLG
24lung adenocarcinoma9.8BRAF, PARK2, ERBB2, KRAS
25colon adenocarcinoma9.8KRAS, FASLG
26breast cancer9.8KRAS, ERBB2, PPP2R1B
27lung cancer9.8KRAS, ERBB2, BRAF, PPP2R1B
28colonic benign neoplasm9.7KRAS, FASLG, BRAF
29colorectal cancer9.7BRAF, FASLG, ERBB2, KRAS
30ovarian cancer9.7KRAS, ERBB2, FASLG, BRAF
31pancreatic cancer9.7BRAF, FASLG, ERBB2, KRAS
32stomach cancer9.6BRAF, FASLG, ERBB2, KRAS
33burkitt's lymphoma9.6PARK2, FASLG, KRAS
34adenocarcinoma9.6KRAS, ERBB2, FASLG, BRAF
35liver cancer9.6PPP2R1B, PARK2, FASLG, KRAS
36melanoma9.5PPP2R1B, BRAF, FASLG, KRAS

Graphical network of the top 20 diseases related to Adenocarcinoma of Lung, Somatic:



Diseases related to adenocarcinoma of lung, somatic

Symptoms for Adenocarcinoma of Lung, Somatic

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Clinical features from OMIM:

211980

Drugs & Therapeutics for Adenocarcinoma of Lung, Somatic

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Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma of Lung, Somatic

Search NIH Clinical Center for Adenocarcinoma of Lung, Somatic

Genetic Tests for Adenocarcinoma of Lung, Somatic

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Anatomical Context for Adenocarcinoma of Lung, Somatic

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MalaCards organs/tissues related to Adenocarcinoma of Lung, Somatic:

32
Lung

Animal Models for Adenocarcinoma of Lung, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Adenocarcinoma of Lung, Somatic:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.8BRAF, PARK2, ERBB2, KRAS
2MP:00020068.4BRAF, FASLG, ERBB2, KRAS
3MP:00053908.4BRAF, PARK2, FASLG, ERBB2
4MP:00053818.4KRAS, ERBB2, FASLG, BRAF
5MP:00053798.3KRAS, ERBB2, FASLG, BRAF
6MP:00053898.2KRAS, ERBB2, FASLG, BRAF
7MP:00053888.1KRAS, ERBB2, FASLG, PARK2, BRAF
8MP:00107718.0BRAF, PARK2, FASLG, ERBB2, KRAS
9MP:00053858.0KRAS, ERBB2, FASLG, PARK2, BRAF
10MP:00053848.0BRAF, PARK2, FASLG, ERBB2, KRAS
11MP:00036317.9BRAF, PARK2, FASLG, ERBB2, KRAS
12MP:00028737.9BRAF, FASLG, ERBB2, KRAS
13MP:00053767.7KRAS, ERBB2, FASLG, PARK2, BRAF

Publications for Adenocarcinoma of Lung, Somatic

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Variations for Adenocarcinoma of Lung, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma of Lung, Somatic:

64
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly466ValVAR_018512
2BRAFp.Leu597ArgVAR_018513
3SLC22A18p.Ser233PheVAR_024062

Clinvar genetic disease variations for Adenocarcinoma of Lung, Somatic:

6
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> T (p.Gly12Cys)single nucleotide variantPathogenicrs121913530GRCh37Chr 12, 25398285: 25398285
2FASLGNM_000639.1(FASLG): c.-844C=single nucleotide variantPathogenicrs763110GRCh37Chr 1, 172627498: 172627498
3PPP2R1BNM_181699.2(PPP2R1B): c.269G> A (p.Gly90Asp)single nucleotide variantPathogenicrs1805076GRCh37Chr 11, 111635566: 111635566
4SLC22A18NM_183233.2(SLC22A18): c.698C> T (p.Ser233Phe)single nucleotide variantPathogenicrs121909071GRCh37Chr 11, 2939260: 2939260

Expression for genes affiliated with Adenocarcinoma of Lung, Somatic

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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma of Lung, Somatic

Search GEO for disease gene expression data for Adenocarcinoma of Lung, Somatic.

Pathways for genes affiliated with Adenocarcinoma of Lung, Somatic

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Pathways related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6BRAF, ERBB2
29.6ERBB2, PPP2R1B
39.5KRAS, ERBB2
4
Show member pathways
9.5KRAS, ERBB2
5
Show member pathways
9.4BRAF, KRAS
69.4KRAS, BRAF
79.4KRAS, BRAF
8
Show member pathways
9.4KRAS, BRAF
9
Show member pathways
9.4KRAS, BRAF
10
Show member pathways
9.4KRAS, BRAF
11
Show member pathways
9.4KRAS, BRAF
12
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.4KRAS, BRAF
139.4BRAF, KRAS
149.4KRAS, BRAF
15
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.2FASLG, BRAF
16
Show member pathways
9.1PPP2R1B, BRAF, ERBB2
17
Show member pathways
9.1ERBB2, BRAF, PPP2R1B
18
Show member pathways
9.1ERBB2, BRAF, PPP2R1B
19
Show member pathways
9.1ERBB2, BRAF, PPP2R1B
20
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0BRAF, ERBB2, KRAS
21
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.0KRAS, ERBB2, BRAF
22
Show member pathways
Signaling Pathways in Glioblastoma37
9.0KRAS, ERBB2, BRAF
23
Show member pathways
9.0KRAS, ERBB2, BRAF
24
Show member pathways
Signal transduction PTEN pathway60
9.0KRAS, ERBB2, BRAF
25
Show member pathways
8.9PPP2R1B, BRAF, KRAS
268.9PPP2R1B, BRAF, KRAS
278.9PPP2R1B, BRAF, KRAS
28
Show member pathways
8.9KRAS, BRAF, PPP2R1B
29
Show member pathways
8.9KRAS, BRAF, PPP2R1B
30
Show member pathways
8.9KRAS, BRAF, PPP2R1B
31
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.8PPP2R1B, FASLG, ERBB2
32
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.7FASLG, PARK2, PPP2R1B
338.7KRAS, ERBB2, FASLG
34
Show member pathways
8.6BRAF, FASLG, KRAS
35
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.6BRAF, FASLG, KRAS
36
Show member pathways
Immune response CD16 signaling in NK cells60
8.6BRAF, FASLG, KRAS
37
Show member pathways
MAPK signaling pathway37
8.6KRAS, FASLG, BRAF
38
Show member pathways
8.5PPP2R1B, PARK2, ERBB2, KRAS
398.5PPP2R1B, FASLG, KRAS
40
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5KRAS, FASLG, PPP2R1B
41
Show member pathways
8.5PPP2R1B, BRAF, ERBB2, KRAS
42
Show member pathways
8.5PPP2R1B, BRAF, ERBB2, KRAS
43
Show member pathways
8.3ERBB2, FASLG, BRAF, PPP2R1B
448.2KRAS, ERBB2, FASLG, BRAF
458.2KRAS, ERBB2, FASLG, BRAF
46
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.2KRAS, ERBB2, FASLG, BRAF

Compounds for genes affiliated with Adenocarcinoma of Lung, Somatic

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Compounds related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
117-(allylamino)-17-demethoxygeldanamycin4410.0BRAF, ERBB2
2panitumumab44 50 1111.8KRAS, BRAF
3erlotinib44 50 1111.8KRAS, ERBB2
4regorafenib50 1110.8KRAS, BRAF
5o6-methylguanine449.8KRAS, BRAF
6crcs449.8KRAS, BRAF
7oxaliplatin44 50 1111.7ERBB2, KRAS
8geldanamycin44 50 61 1112.7ERBB2, PARK2, BRAF
9topotecan44 1110.6ERBB2, FASLG
10gefitinib44 50 1111.6KRAS, ERBB2
11suberoylanilide hydroxamic acid449.6ERBB2, FASLG
12mitoxantrone44 50 1111.6ERBB2, FASLG
13ganciclovir44 1110.5ERBB2, FASLG
14depsipeptide449.5FASLG, BRAF
154-hydroxytamoxifen449.5ERBB2, FASLG
16ifn-alpha449.5FASLG, PARK2
17bortezomib44 50 1111.5FASLG, ERBB2
18cetuximab44 50 1111.5KRAS, ERBB2, BRAF
19ag 1478449.5ERBB2, FASLG
20irinotecan44 50 1111.4BRAF, ERBB2, KRAS
21p002449.4KRAS, ERBB2, BRAF
22valine449.4KRAS, ERBB2, BRAF
23calyculin a44 61 1111.4PPP2R1B, FASLG
24tetracycline44 1110.3FASLG, ERBB2
25phosphoinositide449.3KRAS, PARK2, BRAF
26gtp44 2810.3BRAF, PARK2, KRAS
27carboplatin44 50 1111.3ERBB2, FASLG
28biotin44 24 1111.3ERBB2, FASLG
29agar449.2BRAF, FASLG, ERBB2
30leucovorin44 50 1111.1KRAS, ERBB2, FASLG
315fluorouracil449.0KRAS, ERBB2, FASLG
32progesterone44 28 61 24 1113.0ERBB2, FASLG, BRAF
33lactacystin448.9FASLG, PARK2
34alanine448.8BRAF, PARK2, FASLG, ERBB2
35testosterone44 61 24 1111.8PARK2, FASLG, ERBB2
36aspartate448.7PPP2R1B, BRAF, FASLG, ERBB2
37h2o2448.7PARK2, FASLG, ERBB2, KRAS
38imatinib44 50 1110.7BRAF, FASLG, ERBB2, KRAS
39rapamycin448.6BRAF, FASLG, ERBB2, KRAS
40ly294002448.6BRAF, FASLG, ERBB2, KRAS
41wortmannin448.6BRAF, FASLG, ERBB2, KRAS
42paraffin448.6KRAS, ERBB2, FASLG, BRAF
43cisplatin44 50 61 1111.6BRAF, FASLG, ERBB2, KRAS
44phosphatidylinositol448.6BRAF, FASLG, ERBB2, KRAS
45oligonucleotide448.6KRAS, FASLG, PARK2, BRAF
46paclitaxel44 50 1110.2KRAS, ERBB2, FASLG, PARK2, BRAF
47vegf448.2BRAF, PARK2, FASLG, ERBB2, KRAS
48estrogen448.2KRAS, ERBB2, FASLG, PARK2, BRAF
49tyrosine448.2BRAF, PARK2, FASLG, ERBB2, KRAS
50serine447.7PPP2R1B, BRAF, PARK2, FASLG, ERBB2, KRAS

GO Terms for genes affiliated with Adenocarcinoma of Lung, Somatic

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Cellular components related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perinuclear region of cytoplasmGO:0484718.9ERBB2, FASLG, PARK2

Biological processes related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein phosphorylationGO:0019349.5KRAS, ERBB2
2positive regulation of MAP kinase activityGO:0434069.4KRAS, ERBB2
3negative regulation of neuron apoptotic processGO:0435249.1KRAS, PARK2, BRAF
4activation of MAPKK activityGO:0001869.1KRAS, BRAF
5fibroblast growth factor receptor signaling pathwayGO:0085439.1KRAS, ERBB2, BRAF
6neurotrophin TRK receptor signaling pathwayGO:0480119.0BRAF, ERBB2, KRAS

Molecular functions related to Adenocarcinoma of Lung, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.2ERBB2, PARK2, BRAF
2protein bindingGO:0055157.0KRAS, ERBB2, FASLG, PARK2, BRAF, PPP2R1B

Products for genes affiliated with Adenocarcinoma of Lung, Somatic

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Sources for Adenocarcinoma of Lung, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet