MCID: ADN034
MIFTS: 37

Adenocarcinoma, Ovarian, Somatic malady

Genetic diseases (common) category
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Summaries for Adenocarcinoma, Ovarian, Somatic

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MalaCards based summary: Adenocarcinoma, Ovarian, Somatic is related to fallopian tube cancer and adenocarcinoma of lung, somatic. An important gene associated with Adenocarcinoma, Ovarian, Somatic is PARK2 (parkin RBR E3 ubiquitin protein ligase), and among its related pathways are Akt Signaling Pathway and Sorafenib Pharmacodynamics. The compounds erlotinib and everolimus have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and adipose tissue.

Description from OMIM:46 167000

Aliases & Classifications for Adenocarcinoma, Ovarian, Somatic

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Adenocarcinoma, Ovarian, Somatic, Aliases & Descriptions:

Name: Adenocarcinoma, Ovarian, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Adenocarcinoma, Ovarian, Somatic

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Diseases related to Adenocarcinoma, Ovarian, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1fallopian tube cancer10.4BRCA1
2adenocarcinoma of lung, somatic10.4PARK2, ERBB2
3breast cancer, somatic10.3PIK3CA, KRAS
4large cell carcinoma10.2KRAS, ERBB2
5fanconi's anemia10.2PARK2, BRCA1
6factor vii deficiency10.2ERBB2, KRAS
7cystadenoma10.2BRCA1, KRAS
8male breast cancer10.2ERBB2, BRCA1
9lynch syndrome10.2KRAS, BRCA1
10breast cancer10.2BRCA1, AKT1
11autosomal dominant disease10.2BRCA1, AKT1
12breast cancer, invasive ductal10.2ERBB2, BRCA1
13ductal carcinoma in situ10.2BRCA1, ERBB2
14breast ductal carcinoma10.1BRCA1, ERBB2
15li-fraumeni syndrome10.1ERBB2, BRCA1
16gastric cancer, somatic10.1PIK3CA, ERBB2, KRAS
17cowden disease10.1PIK3CA, BRCA1
18cholangiocarcinoma10.1KRAS, ERBB2, PIK3CA
19tubular adenocarcinoma10.1ERBB2, CTNNB1
20tuberous sclerosis10.1AKT1, PIK3CA
21hepatocellular carcinoma, somatic10.1CTNNB1, PIK3CA
22lung cancer10.0PIK3CA, ERBB2, KRAS
23aplastic anemia10.0BRCA1, PALB2
24malignant mixed mullerian tumor10.0CTNNB1, KRAS, ERBB2
25endometrial carcinoma10.0CTNNB1, KRAS, ERBB2
26kidney rhabdoid cancer10.0PARK2, PIK3CA
27thyroid cancer, anaplastic10.0PIK3CA, CTNNB1
28pancreatic cancer9.9CTNNB1, KRAS, AKT1
29burkitt's lymphoma9.9PIK3CA, PARK2, AKT1, KRAS
30colorectal cancer, somatic9.9CTNNB1, AKT1, PIK3CA
31kidney cancer9.9PIK3CA, PARK2, AKT1
32familial adenomatous polyposis9.8CTNNB1, KRAS, BRCA1
33bladder carcinoma9.8PIK3CA, BRCA1, ERBB2, KRAS
34prostate cancer9.8CTNNB1, ERBB2, AKT1
35astrocytoma9.8PIK3CA, BRCA1, PARK2, AKT1
36ovarian cancer, somatic9.8PIK3CA, AKT1, OPCML, CTNNB1
37gastric adenocarcinoma9.8PIK3CA, ERBB2, KRAS, CTNNB1
38colorectal cancer9.7PIK3CA, ERBB2, KRAS, CTNNB1
39medulloblastoma9.7CTNNB1, ERBB2, AKT1, PIK3CA
40colonic benign neoplasm9.7PIK3CA, AKT1, KRAS, CTNNB1
41leukemia9.7PIK3CA, BRCA1, PARK2, AKT1, KRAS
42lung adenocarcinoma9.6PIK3CA, PARK2, ERBB2, KRAS, CTNNB1
43liver cancer9.6PIK3CA, PARK2, AKT1, KRAS, CTNNB1
44stomach cancer9.6PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
45melanoma9.6CTNNB1, KRAS, AKT1, PIK3CA
46non-small cell lung carcinoma9.6PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
47tongue squamous cell carcinoma9.6PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
48retinoblastoma9.5KRAS, ERBB2, AKT1, PARK2, BRCA1, PIK3CA
49ovarian cancer9.5PIK3CA, BRCA1, ERBB2, KRAS, CTNNB1
50adenocarcinoma9.3PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1

Graphical network of the top 20 diseases related to Adenocarcinoma, Ovarian, Somatic:



Diseases related to adenocarcinoma, ovarian, somatic

Symptoms for Adenocarcinoma, Ovarian, Somatic

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Clinical features from OMIM:

167000

Drugs & Therapeutics for Adenocarcinoma, Ovarian, Somatic

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Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma, Ovarian, Somatic

Search NIH Clinical Center for Adenocarcinoma, Ovarian, Somatic

Genetic Tests for Adenocarcinoma, Ovarian, Somatic

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Anatomical Context for Adenocarcinoma, Ovarian, Somatic

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Animal Models for Adenocarcinoma, Ovarian, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Adenocarcinoma, Ovarian, Somatic:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7CTNNB1, KRAS, BRCA1
2MP:00053758.5PIK3CA, RRAS2, BRCA1, AKT1
3MP:00053718.0BRCA1, PALB2, ERBB2, KRAS, CTNNB1
4MP:00053887.9BRCA1, PARK2, AKT1, ERBB2, KRAS, CTNNB1
5MP:00053907.8BRCA1, PARK2, AKT1, ERBB2, CTNNB1
6MP:00028737.6BRCA1, AKT1, ERBB2, KRAS, CTNNB1
7MP:00053797.6PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1
8MP:00053897.5PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1
9MP:00053697.4PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
10MP:00053867.3PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
11MP:00053877.2PIK3CA, RRAS2, BRCA1, AKT1, KRAS, CTNNB1
12MP:00053807.2PIK3CA, BRCA1, PALB2, AKT1, ERBB2, KRAS
13MP:00053767.2PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
14MP:00107716.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
15MP:00053846.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
16MP:00036316.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
17MP:00107686.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
18MP:00020066.7CTNNB1, PIK3CA, RRAS2, BRCA1, PALB2, AKT1
19MP:00053856.4PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1
20MP:00053786.4PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1

Publications for Adenocarcinoma, Ovarian, Somatic

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Variations for Adenocarcinoma, Ovarian, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

64
id Symbol AA change Variation ID SNP ID
1BRCA1p.Cys61GlyVAR_007757rs28897672
2BRCA1p.Cys1697ArgVAR_020702
3BRCA1p.Arg1699TrpVAR_020703
4CTNNB1p.Ser37CysVAR_017625
5CTNNB1p.Thr41IleVAR_017630
6OPCMLp.Pro95ArgVAR_055421
7PIK3CAp.His1047ArgVAR_026192

Clinvar genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

6
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenicrs121913530GRCh37Chr 12, 25398285: 25398285
2PALB2NM_024675.3(PALB2): c.1050_1053delAACA (p.Thr351Argfs)deletionPathogenicrs515726060GRCh38Chr 16, 23635493: 23635496
3ERBB2NM_001005862.2(ERBB2): c.2480A> G (p.Asn827Ser)single nucleotide variantPathogenicrs28933370GRCh37Chr 17, 37881378: 37881378
4AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551
5CTNNB1NM_001904.3(CTNNB1): c.110C> G (p.Ser37Cys)single nucleotide variantLikely pathogenicrs121913403GRCh37Chr 3, 41266113: 41266113
6PARK2PARK2, DELdeletionPathogenic
7OPCMLNM_001012393.1(OPCML): c.263C> G (p.Pro88Arg)single nucleotide variantPathogenicrs137852691GRCh37Chr 11, 132527098: 132527098
8RRAS2NM_001177314.1(RRAS2): c.110A> T (p.Gln37Leu)single nucleotide variantPathogenicrs113954997GRCh37Chr 11, 14316390: 14316390

Expression for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma, Ovarian, Somatic

Search GEO for disease gene expression data for Adenocarcinoma, Ovarian, Somatic.

Pathways for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Pathways related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3AKT1, ERBB2, KRAS
2
Show member pathways
9.2PIK3CA, AKT1, KRAS
39.2PIK3CA, AKT1, KRAS
4
Show member pathways
9.2PIK3CA, AKT1, KRAS
59.2KRAS, AKT1, PIK3CA
6
Show member pathways
9.2PIK3CA, AKT1, ERBB2
7
Show member pathways
9.2PIK3CA, AKT1, ERBB2
89.2AKT1, ERBB2, PIK3CA
99.2ERBB2, AKT1, PIK3CA
10
Show member pathways
9.0PIK3CA, RRAS2, AKT1
11
Show member pathways
IFN-gamma pathway37
8.9PIK3CA, BRCA1, AKT1
12
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
8.9AKT1, BRCA1, PIK3CA
138.9AKT1, KRAS, CTNNB1
148.9AKT1, ERBB2, CTNNB1
15
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.8KRAS, ERBB2, AKT1, PIK3CA
16
Show member pathways
8.8PIK3CA, AKT1, ERBB2, KRAS
17
Show member pathways
8.8PIK3CA, AKT1, ERBB2, KRAS
18
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.8PIK3CA, AKT1, ERBB2, KRAS
19
Show member pathways
8.8PIK3CA, AKT1, ERBB2, KRAS
20
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.8KRAS, ERBB2, AKT1, PIK3CA
21
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
8.8PIK3CA, AKT1, ERBB2, KRAS
22
Show member pathways
8.8KRAS, ERBB2, AKT1, PIK3CA
238.7CTNNB1, AKT1, RRAS2
248.7PIK3CA, AKT1, CTNNB1
25
Show member pathways
VEGFR1 specific signals37
8.7PIK3CA, AKT1, CTNNB1
26
Show member pathways
Development A2B receptor action via G protein alpha s60
8.7PIK3CA, AKT1, CTNNB1
278.7PIK3CA, AKT1, CTNNB1
28
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
8.7PIK3CA, AKT1, CTNNB1
29
Show member pathways
8.7PIK3CA, RRAS2, AKT1, KRAS
308.6CTNNB1, AKT1, BRCA1
318.6BRCA1, AKT1, CTNNB1
328.6PIK3CA, BRCA1, ERBB2, KRAS
338.6KRAS, AKT1, BRCA1, PIK3CA
348.4CTNNB1, KRAS, AKT1, RRAS2
35
Show member pathways
8.4RRAS2, AKT1, KRAS, CTNNB1
36
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.4PIK3CA, AKT1, KRAS, CTNNB1
378.4PIK3CA, AKT1, KRAS, CTNNB1
38
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
8.3PIK3CA, AKT1, ERBB2, CTNNB1
398.3BRCA1, AKT1, KRAS, CTNNB1
40
Show member pathways
Signal transduction PTEN pathway60
8.0PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
418.0PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
42
Show member pathways
8.0CTNNB1, KRAS, ERBB2, AKT1, PIK3CA
43
Show member pathways
7.9PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
44
Show member pathways
7.9PIK3CA, RRAS2, AKT1, KRAS, CTNNB1
457.9PIK3CA, RRAS2, AKT1, KRAS, CTNNB1
46
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
7.8PIK3CA, RRAS2, AKT1, ERBB2, CTNNB1
47
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
7.8PIK3CA, RRAS2, AKT1, ERBB2, CTNNB1
487.5PIK3CA, RRAS2, AKT1, ERBB2, KRAS, CTNNB1
497.4PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1
50
Show member pathways
Signaling Pathways in Glioblastoma37
7.4CTNNB1, KRAS, ERBB2, AKT1, BRCA1, PIK3CA

Compounds for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Compounds related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1erlotinib44 50 1111.5KRAS, ERBB2, PIK3CA
2everolimus44 50 1111.5ERBB2, AKT1, PIK3CA
3oxaliplatin44 50 1111.4KRAS, ERBB2, BRCA1
4cetuximab44 50 1111.3ERBB2, KRAS, CTNNB1
5carboplatin44 50 1111.2ERBB2, AKT1, BRCA1
6crcs449.1CTNNB1, KRAS, PIK3CA
7gemcitabine44 50 1111.1ERBB2, AKT1, BRCA1
8celecoxib44 61 28 50 24 1114.0CTNNB1, ERBB2, AKT1
9trastuzumab44 50 1111.0CTNNB1, ERBB2, PIK3CA
10indole-3-carbinol448.9BRCA1, AKT1, CTNNB1
11geldanamycin44 50 61 1111.9PARK2, ERBB2, CTNNB1
12etoposide44 50 61 1111.8ERBB2, AKT1, BRCA1, PIK3CA
13ag 1478448.8CTNNB1, ERBB2, AKT1, PIK3CA
14imatinib44 50 1110.8CTNNB1, KRAS, ERBB2, PIK3CA
15p002448.7CTNNB1, KRAS, ERBB2, BRCA1
16nmda44 289.7PIK3CA, PARK2, AKT1, CTNNB1
17mg 13244 619.7BRCA1, PARK2, AKT1, CTNNB1
184-hydroxytamoxifen448.7BRCA1, AKT1, ERBB2, CTNNB1
19adriamycin448.6CTNNB1, ERBB2, AKT1, BRCA1
20glycogen44 249.6PIK3CA, PARK2, AKT1, CTNNB1
21adpribose448.5CTNNB1, BRCA1, PIK3CA
22resveratrol44 61 24 1111.5PIK3CA, BRCA1, ERBB2, CTNNB1
23phosphoinositide448.5PIK3CA, PARK2, AKT1, KRAS, CTNNB1
24gefitinib44 50 1110.4PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
25phosphotyrosine448.4PIK3CA, BRCA1, ERBB2, CTNNB1
26rapamycin448.4PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
27ly294002448.4PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
28wortmannin448.4PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
29guanine44 24 1110.4BRCA1, PARK2, AKT1, ERBB2, CTNNB1
30nocodazole44 119.3CTNNB1, AKT1, BRCA1
31paraffin448.3BRCA1, AKT1, ERBB2, KRAS, CTNNB1
325fluorouracil448.2PIK3CA, BRCA1, ERBB2, KRAS, CTNNB1
33alanine448.1BRCA1, PARK2, AKT1, ERBB2, CTNNB1
34tamoxifen44 50 28 1111.1PIK3CA, BRCA1, AKT1, ERBB2, CTNNB1
35steroid448.1PIK3CA, BRCA1, PARK2, ERBB2, CTNNB1
36threonine448.1PIK3CA, RRAS2, PARK2, AKT1, CTNNB1
37doxorubicin44 50 1110.1CTNNB1, ERBB2, AKT1, BRCA1, PIK3CA
38genistein44 28 61 2 24 1113.1PIK3CA, BRCA1, AKT1, ERBB2, CTNNB1
39gtp44 289.0PIK3CA, RRAS2, PARK2, AKT1, KRAS, CTNNB1
40testosterone44 61 24 1110.8PIK3CA, BRCA1, PARK2, AKT1, ERBB2, CTNNB1
41retinoic acid44 248.8PIK3CA, BRCA1, AKT1, KRAS, CTNNB1
42cisplatin44 50 61 1110.8PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1
43phosphatidylinositol447.8PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1
44agar447.7PIK3CA, RRAS2, BRCA1, AKT1, ERBB2, CTNNB1
45paclitaxel44 50 119.5CTNNB1, PIK3CA, BRCA1, PARK2, AKT1, ERBB2
46h2o2447.5PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
47vegf447.5PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
48estrogen447.5PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
49serine447.0PIK3CA, RRAS2, BRCA1, PARK2, AKT1, ERBB2
50tyrosine447.0PIK3CA, RRAS2, BRCA1, PARK2, AKT1, ERBB2

GO Terms for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Cellular components related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058866.5CTNNB1, OPCML, KRAS, ERBB2, AKT1, BRCA1

Biological processes related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1striated muscle cell differentiationGO:05114610.0KRAS, AKT1
2negative regulation of release of cytochrome c from mitochondriaGO:0902019.9AKT1, PARK2
3positive regulation of nitric-oxide synthase activityGO:0510009.9KRAS, AKT1
4protein kinase B signalingGO:0434919.7AKT1, PIK3CA
5positive regulation of protein phosphorylationGO:0019349.6KRAS, ERBB2, AKT1
6protein autoubiquitinationGO:0518659.6PARK2, BRCA1
7negative regulation of neuron apoptotic processGO:0435249.6PIK3CA, PARK2, KRAS
8positive regulation of peptidyl-serine phosphorylationGO:0331389.5AKT1, PIK3CA
9positive regulation of MAP kinase activityGO:0434069.5KRAS, ERBB2
10regulation of angiogenesisGO:0457659.4ERBB2, CTNNB1
11insulin receptor signaling pathwayGO:0082869.4PIK3CA, AKT1, KRAS
12phosphatidylinositol-mediated signalingGO:0480159.4ERBB2, AKT1, PIK3CA
13cellular response to indole-3-methanolGO:0716819.3BRCA1, CTNNB1
14fibroblast growth factor receptor signaling pathwayGO:0085439.2KRAS, ERBB2, AKT1, PIK3CA
15Fc-epsilon receptor signaling pathwayGO:0380959.2PIK3CA, AKT1, ERBB2, KRAS
16epidermal growth factor receptor signaling pathwayGO:0071739.1KRAS, ERBB2, AKT1, PIK3CA
17protein ubiquitinationGO:0165679.1BRCA1, PARK2, AKT1
18neurotrophin TRK receptor signaling pathwayGO:0480119.1KRAS, ERBB2, AKT1, PIK3CA
19androgen receptor signaling pathwayGO:0305218.9CTNNB1, BRCA1
20innate immune responseGO:0450878.3PIK3CA, AKT1, ERBB2, KRAS, CTNNB1

Molecular functions related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:0163019.4AKT1, PIK3CA
2kinase bindingGO:0199009.4CTNNB1, PARK2
3androgen receptor bindingGO:0506818.7CTNNB1, BRCA1
4enzyme bindingGO:0198998.6BRCA1, AKT1, CTNNB1
5protein bindingGO:0055156.2CTNNB1, PIK3CA, RRAS2, BRCA1, PARK2, PALB2

Products for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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  • Antibodies
  • Proteins
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Sources for Adenocarcinoma, Ovarian, Somatic

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet