MCID: ADN034
MIFTS: 28

Adenocarcinoma, Ovarian, Somatic malady

Genetic diseases (common) category

Summaries for Adenocarcinoma, Ovarian, Somatic

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48OMIM, 34MalaCards
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MalaCards: Adenocarcinoma, Ovarian, Somatic is related to fanconi's anemia and ovarian cancer, somatic. An important gene associated with Adenocarcinoma, Ovarian, Somatic is PARK2 (parkin RBR E3 ubiquitin protein ligase), and among its related pathways are Integrated Pancreatic Cancer Pathway and Glioma. The compounds colchicine and lactacystin have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and respiratory system.

Description from OMIM:48 167000

Aliases & Classifications for Adenocarcinoma, Ovarian, Somatic

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48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

adenocarcinoma, ovarian, somatic 48


Related Diseases for Adenocarcinoma, Ovarian, Somatic

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Adenocarcinoma, Ovarian, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1fanconi's anemia10.0PARK2, BRCA1
2ovarian cancer, somatic10.0OPCML, CTNNB1
3familial adenomatous polyposis10.0CTNNB1, BRCA1
4lung adenocarcinoma10.0CTNNB1, PARK2
5endometrial carcinoma9.9CTNNB1, BRCA1
6breast cancer9.9CTNNB1, PARK2, BRCA1
7ovarian cancer9.9CTNNB1, OPCML, PARK2, BRCA1

Graphical network of diseases related to Adenocarcinoma, Ovarian, Somatic:



Diseases related to adenocarcinoma, ovarian, somatic

Symptoms for Adenocarcinoma, Ovarian, Somatic

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Sources:
48OMIM
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Clinical features from OMIM:

167000

Drugs & Therapeutics for Adenocarcinoma, Ovarian, Somatic

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenocarcinoma, Ovarian, Somatic

Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma, Ovarian, Somatic

Search NIH Clinical Center for Adenocarcinoma, Ovarian, Somatic

Search CenterWatch for Adenocarcinoma, Ovarian, Somatic

Genetic Tests for Adenocarcinoma, Ovarian, Somatic

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Anatomical Context for Adenocarcinoma, Ovarian, Somatic

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Animal Models for Adenocarcinoma, Ovarian, Somatic or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adenocarcinoma, Ovarian, Somatic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7CTNNB1, OPCML, PARK2
2MP:00053888.5CTNNB1, PARK2, BRCA1
3MP:00107718.5CTNNB1, PARK2, BRCA1
4MP:00053698.4BRCA1, PARK2, CTNNB1
5MP:00053908.2CTNNB1, PARK2, BRCA1

Publications for Adenocarcinoma, Ovarian, Somatic

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Variations for Adenocarcinoma, Ovarian, Somatic

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

65
id Symbol AA change Variation ID SNP ID
1BRCA1p.Cys61GlyVAR_007757rs28897672
2BRCA1p.Cys1697ArgVAR_020702
3BRCA1p.Arg1699TrpVAR_020703
4CTNNB1p.Ser37CysVAR_017625
5CTNNB1p.Thr41IleVAR_017630
6OPCMLp.Pro95ArgVAR_055421

Clinvar genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

1
id Gene Name Type Significance SNP ID Assembly Location
1CDH1NM_004360.3(CDH1): c.2512A> G (p.Ser838Gly)single nucleotide variantLikely benign, Pathogenic, Uncertain significancers121964872GRCh37Chr 16, 68867265: 68867265
2KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
3PALB2NM_024675.3(PALB2): c.1050_1053delAACA (p.Thr351Argfs)deletionPathogenicrs515726060GRCh38Chr 16, 23635493: 23635496
4ERBB2NM_001005862.2(ERBB2): c.2480A> G (p.Asn827Ser)single nucleotide variantPathogenicrs28933370GRCh37Chr 17, 37881378: 37881378
5AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551
6CTNNB1NM_001904.3(CTNNB1): c.110C> G (p.Ser37Cys)single nucleotide variantLikely pathogenic, Pathogenicrs121913403GRCh37Chr 3, 41266113: 41266113
7PARK2PARK2, DELdeletionPathogenic
8OPCMLNM_001012393.1(OPCML): c.263C> G (p.Pro88Arg)single nucleotide variantPathogenicrs137852691GRCh37Chr 11, 132527098: 132527098
9RRAS2NM_001177314.1(RRAS2): c.110A> T (p.Gln37Leu)single nucleotide variantPathogenicrs113954997GRCh37Chr 11, 14316390: 14316390

Expression for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma, Ovarian, Somatic

Search GEO for disease gene expression data for Adenocarcinoma, Ovarian, Somatic.

Pathways for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0CTNNB1, BRCA1
2
Show member pathways
Signaling Pathways in Glioblastoma39
9.0CTNNB1, BRCA1
39.0BRCA1, CTNNB1
49.0CTNNB1, BRCA1
59.0CTNNB1, BRCA1

Compounds for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Sources:
46Novoseek, 62Tocris Bioscience, 3BitterDB, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1colchicine46 62 3 30 1213.7BRCA1, PARK2
2lactacystin469.6PARK2, BRCA1
3geldanamycin46 52 62 1212.5CTNNB1, PARK2
4sodium bisulfite469.4BRCA1, CTNNB1
5indole-3-carbinol469.4BRCA1, CTNNB1
6leptomycin b46 6210.4BRCA1, CTNNB1
74-hydroxytamoxifen469.4BRCA1, CTNNB1
8bleomycin46 1210.4BRCA1, CTNNB1
9adpribose469.4BRCA1, CTNNB1
10nocodazole46 1210.4CTNNB1, BRCA1
11linoleic acid30 46 2511.3BRCA1, CTNNB1
12p002469.3CTNNB1, BRCA1
13resveratrol46 62 25 1212.3CTNNB1, BRCA1
14adriamycin469.3BRCA1, CTNNB1
155-aza-2deoxycytidine469.2CTNNB1, BRCA1
16glycerol46 25 1211.2CTNNB1, BRCA1
175fluorouracil469.2BRCA1, CTNNB1
18agar469.1CTNNB1, BRCA1
19phosphotyrosine469.1BRCA1, CTNNB1
20tamoxifen46 52 30 1211.9BRCA1, CTNNB1
21mg 13246 629.9CTNNB1, PARK2, BRCA1
22guanine46 25 1210.9CTNNB1, PARK2, BRCA1
23paclitaxel46 52 1210.9CTNNB1, PARK2, BRCA1
24glutamine468.9BRCA1, PARK2, CTNNB1
25lysine468.9CTNNB1, PARK2, BRCA1
26h2o2468.9CTNNB1, PARK2, BRCA1
27testosterone46 62 25 1211.9CTNNB1, PARK2, BRCA1
28steroid468.9BRCA1, PARK2, CTNNB1
29oligonucleotide468.9CTNNB1, PARK2, BRCA1
30vegf468.9CTNNB1, PARK2, BRCA1
31alanine468.9CTNNB1, PARK2, BRCA1
32nmda46 309.8CTNNB1, PARK2
33estrogen468.8BRCA1, PARK2, CTNNB1
34atp46 309.8CTNNB1, PARK2, BRCA1
35cysteine468.8BRCA1, PARK2, CTNNB1
36serine468.5CTNNB1, PARK2, BRCA1
37tyrosine468.5CTNNB1, PARK2, BRCA1

GO Terms for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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17Gene Ontology
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Cellular components related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin ligase complexGO:0001519.3PARK2, BRCA1

Biological processes related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein autoubiquitinationGO:0518659.3PARK2, BRCA1
2protein ubiquitinationGO:0165679.3PARK2, BRCA1
3cellular response to indole-3-methanolGO:0716819.1CTNNB1, BRCA1
4androgen receptor signaling pathwayGO:0305218.9BRCA1, CTNNB1
5positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.8CTNNB1, PARK2

Molecular functions related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.4PARK2, BRCA1
2kinase bindingGO:0199009.3CTNNB1, PARK2
3androgen receptor bindingGO:0506819.2CTNNB1, BRCA1
4protein kinase bindingGO:0199019.1CTNNB1, PARK2
5transcription regulatory region DNA bindingGO:0442129.1CTNNB1, BRCA1
6transcription coactivator activityGO:0037139.0BRCA1, CTNNB1
7ubiquitin-protein ligase activityGO:0048429.0PARK2, BRCA1
8enzyme bindingGO:0198998.9CTNNB1, BRCA1

Products for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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  • Antibodies
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Sources for Adenocarcinoma, Ovarian, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet