MCID: ADN034
MIFTS: 37

Adenocarcinoma, Ovarian, Somatic malady

Genetic diseases (common) category

Summaries for Adenocarcinoma, Ovarian, Somatic

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MalaCards based summary: Adenocarcinoma, Ovarian, Somatic is related to fallopian tube cancer and adenocarcinoma of lung, somatic. An important gene associated with Adenocarcinoma, Ovarian, Somatic is PARK2 (parkin RBR E3 ubiquitin protein ligase), and among its related pathways are Akt Signaling Pathway and Renal cell carcinoma. The compounds erlotinib and everolimus have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and adipose tissue.

Description from OMIM:46 167000

Aliases & Classifications for Adenocarcinoma, Ovarian, Somatic

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Adenocarcinoma, Ovarian, Somatic, Aliases & Descriptions:

Name: Adenocarcinoma, Ovarian, Somatic 46


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Adenocarcinoma, Ovarian, Somatic

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Diseases related to Adenocarcinoma, Ovarian, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1fallopian tube cancer10.4BRCA1
2adenocarcinoma of lung, somatic10.4ERBB2, PARK2
3breast cancer, somatic10.3KRAS, PIK3CA
4large cell carcinoma10.2KRAS, ERBB2
5fanconi's anemia10.2BRCA1, PARK2
6factor vii deficiency10.2KRAS, ERBB2
7cystadenoma10.2BRCA1, KRAS
8male breast cancer10.2ERBB2, BRCA1
9lynch syndrome10.2BRCA1, KRAS
10breast cancer10.2BRCA1, AKT1
11breast cancer, invasive ductal10.2ERBB2, BRCA1
12autosomal dominant disease10.2BRCA1, AKT1
13ductal carcinoma in situ10.2BRCA1, ERBB2
14breast ductal carcinoma10.1BRCA1, ERBB2
15li-fraumeni syndrome10.1BRCA1, ERBB2
16gastric cancer, somatic10.1PIK3CA, ERBB2, KRAS
17cowden disease10.1BRCA1, PIK3CA
18cholangiocarcinoma10.1PIK3CA, ERBB2, KRAS
19tubular adenocarcinoma10.1ERBB2, CTNNB1
20tuberous sclerosis10.1AKT1, PIK3CA
21hepatocellular carcinoma, somatic10.1CTNNB1, PIK3CA
22lung cancer10.0KRAS, ERBB2, PIK3CA
23aplastic anemia10.0BRCA1, PALB2
24malignant mixed mullerian tumor10.0KRAS, CTNNB1, ERBB2
25endometrial carcinoma10.0KRAS, ERBB2, CTNNB1
26kidney rhabdoid cancer10.0PIK3CA, PARK2
27thyroid cancer, anaplastic10.0CTNNB1, PIK3CA
28pancreatic cancer9.9CTNNB1, AKT1, KRAS
29burkitt's lymphoma9.9PIK3CA, PARK2, KRAS, AKT1
30colorectal cancer, somatic9.9AKT1, CTNNB1, PIK3CA
31kidney cancer9.9PIK3CA, PARK2, AKT1
32familial adenomatous polyposis9.8BRCA1, CTNNB1, KRAS
33bladder carcinoma9.8BRCA1, PIK3CA, ERBB2, KRAS
34prostate cancer9.8AKT1, ERBB2, CTNNB1
35astrocytoma9.8BRCA1, PARK2, AKT1, PIK3CA
36ovarian cancer, somatic9.8PIK3CA, AKT1, OPCML, CTNNB1
37gastric adenocarcinoma9.8ERBB2, CTNNB1, KRAS, PIK3CA
38colorectal cancer9.7CTNNB1, KRAS, ERBB2, PIK3CA
39medulloblastoma9.7AKT1, ERBB2, PIK3CA, CTNNB1
40colonic benign neoplasm9.7CTNNB1, PIK3CA, AKT1, KRAS
41leukemia9.7KRAS, AKT1, PARK2, PIK3CA, BRCA1
42lung adenocarcinoma9.6CTNNB1, ERBB2, KRAS, PARK2, PIK3CA
43liver cancer9.6KRAS, CTNNB1, PARK2, AKT1, PIK3CA
44stomach cancer9.6CTNNB1, ERBB2, PIK3CA, AKT1, KRAS
45melanoma9.6PIK3CA, AKT1, CTNNB1, KRAS
46non-small cell lung carcinoma9.6PIK3CA, ERBB2, AKT1, KRAS, CTNNB1
47tongue squamous cell carcinoma9.6PIK3CA, AKT1, ERBB2, KRAS, CTNNB1
48retinoblastoma9.5KRAS, ERBB2, AKT1, PIK3CA, BRCA1, PARK2
49ovarian cancer9.5BRCA1, PIK3CA, ERBB2, KRAS, CTNNB1
50adenocarcinoma9.3PIK3CA, BRCA1, KRAS, CTNNB1, AKT1, ERBB2

Graphical network of the top 20 diseases related to Adenocarcinoma, Ovarian, Somatic:



Diseases related to adenocarcinoma, ovarian, somatic

Symptoms for Adenocarcinoma, Ovarian, Somatic

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Clinical features from OMIM:

167000

Drugs & Therapeutics for Adenocarcinoma, Ovarian, Somatic

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Drug clinical trials:

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Search NIH Clinical Center for Adenocarcinoma, Ovarian, Somatic

Genetic Tests for Adenocarcinoma, Ovarian, Somatic

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Anatomical Context for Adenocarcinoma, Ovarian, Somatic

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Animal Models for Adenocarcinoma, Ovarian, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Adenocarcinoma, Ovarian, Somatic:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7CTNNB1, KRAS, BRCA1
2MP:00053758.5PIK3CA, RRAS2, BRCA1, AKT1
3MP:00053718.0BRCA1, PALB2, ERBB2, KRAS, CTNNB1
4MP:00053887.9BRCA1, PARK2, AKT1, ERBB2, KRAS, CTNNB1
5MP:00053907.8BRCA1, PARK2, AKT1, ERBB2, CTNNB1
6MP:00028737.6BRCA1, AKT1, ERBB2, KRAS, CTNNB1
7MP:00053797.6PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1
8MP:00053897.5PIK3CA, BRCA1, AKT1, ERBB2, KRAS, CTNNB1
9MP:00053697.4PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
10MP:00053867.3PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
11MP:00053877.2PIK3CA, RRAS2, BRCA1, AKT1, KRAS, CTNNB1
12MP:00053807.2PIK3CA, BRCA1, PALB2, AKT1, ERBB2, KRAS
13MP:00053767.2PIK3CA, BRCA1, PARK2, AKT1, ERBB2, KRAS
14MP:00107716.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
15MP:00053846.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
16MP:00036316.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
17MP:00107686.9PIK3CA, BRCA1, PARK2, PALB2, AKT1, ERBB2
18MP:00020066.7CTNNB1, PIK3CA, RRAS2, BRCA1, PALB2, AKT1
19MP:00053856.4PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1
20MP:00053786.4PIK3CA, RRAS2, BRCA1, PARK2, PALB2, AKT1

Publications for Adenocarcinoma, Ovarian, Somatic

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Variations for Adenocarcinoma, Ovarian, Somatic

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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

63
id Symbol AA change Variation ID SNP ID
1BRCA1p.Cys61GlyVAR_007757rs28897672
2BRCA1p.Cys1697ArgVAR_020702
3BRCA1p.Arg1699TrpVAR_020703
4CTNNB1p.Ser37CysVAR_017625
5CTNNB1p.Thr41IleVAR_017630
6OPCMLp.Pro95ArgVAR_055421
7PIK3CAp.His1047ArgVAR_026192

Clinvar genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

7 (show all 32)
id Gene Name Type Significance SNP ID Assembly Location
1KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
2PALB2NM_024675.3(PALB2): c.1050_1053delAACA (p.Thr351Argfs)deletionPathogenicrs515726060GRCh38Chr 16, 23635493: 23635496
3ERBB2NM_001005862.2(ERBB2): c.2480A> G (p.Asn827Ser)single nucleotide variantPathogenicrs28933370GRCh37Chr 17, 37881378: 37881378
4AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551
5NC_012920.1: m.14743A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 14743: 14743
6MT-CYBNC_012920.1: m.14753C> Tsingle nucleotide variantLikely pathogenicGRCh38Chr MT, 14753: 14753
7MT-CYBNC_012920.1: m.14784T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 14784: 14784
8MT-CYBNC_012920.1: m.15058C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15058: 15058
9MT-CYBNC_012920.1: m.15098A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15098: 15098
10MT-CYBNC_012920.1: m.15314G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15314: 15314
11MT-CYBNC_012920.1: m.15328A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15328: 15328
12MT-CYBNC_012920.1: m.15334C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15334: 15334
13MT-CYBNC_012920.1: m.15363A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15363: 15363
14MT-CYBNC_012920.1: m.15453T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15453: 15453
15MT-CYBNC_012920.1: m.15459C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15459: 15459
16MT-CYBNC_012920.1: m.15511T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15511: 15511
17MT-CYBNC_012920.1: m.15884G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15884: 15884
18MT-TTNC_012920.1: m.15890C> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15890: 15890
19MT-TTNC_012920.1: m.15928G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15928: 15928
20MT-TTNC_012920.1: m.15932T> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15932: 15932
21MT-TTNC_012920.1: m.15943T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15943: 15943
22MT-CYBNC_012920.1: m.15061A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15061: 15061
23MT-CYBNC_012920.1: m.15148G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15148: 15148
24MT-CYBNC_012920.1: m.15259C> Tsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15259: 15259
25MT-CYBNC_012920.1: m.15431G> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15431: 15431
26MT-CYBNC_012920.1: m.15452C> Asingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15452: 15452
27MT-CYBNC_012920.1: m.15607A> Gsingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15607: 15607
28MT-CYBNC_012920.1: m.15670T> Csingle nucleotide variantLikely pathogenicGRCh37Chr MT, 15670: 15670
29CTNNB1NM_001904.3(CTNNB1): c.110C> G (p.Ser37Cys)single nucleotide variantLikely pathogenic, Pathogenicrs121913403GRCh37Chr 3, 41266113: 41266113
30PARK2PARK2, DELdeletionPathogenic
31OPCMLNM_001012393.1(OPCML): c.263C> G (p.Pro88Arg)single nucleotide variantPathogenicrs137852691GRCh37Chr 11, 132527098: 132527098
32RRAS2NM_001177314.1(RRAS2): c.110A> T (p.Gln37Leu)single nucleotide variantPathogenicrs113954997GRCh37Chr 11, 14316390: 14316390

Expression for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Pathways for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Pathways related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ERBB2, AKT1, KRAS
29.2PIK3CA, AKT1, KRAS
3
Show member pathways
9.2PIK3CA, AKT1, KRAS
4
Show member pathways
9.2PIK3CA, KRAS, AKT1
59.2KRAS, PIK3CA, AKT1
6
Show member pathways
9.2PIK3CA, AKT1, ERBB2
79.2PIK3CA, AKT1, ERBB2
8
Show member pathways
9.2PIK3CA, AKT1, ERBB2
99.2ERBB2, PIK3CA, AKT1
10
Show member pathways
9.0RRAS2, AKT1, PIK3CA
11
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades59
8.9AKT1, BRCA1, PIK3CA
12
Show member pathways
IFN-gamma pathway37
8.9BRCA1, PIK3CA, AKT1
138.9AKT1, KRAS, CTNNB1
148.9AKT1, ERBB2, CTNNB1
15
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling59
Leptin signaling pathway37
8.8PIK3CA, KRAS, AKT1, ERBB2
16
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
8.8KRAS, ERBB2, AKT1, PIK3CA
17
Show member pathways
8.8PIK3CA, AKT1, ERBB2, KRAS
18
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
8.8AKT1, PIK3CA, ERBB2, KRAS
19
Show member pathways
8.8KRAS, AKT1, ERBB2, PIK3CA
20
Show member pathways
8.8ERBB2, KRAS, PIK3CA, AKT1
21
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
8.8AKT1, ERBB2, PIK3CA, KRAS
22
Show member pathways
8.8ERBB2, AKT1, PIK3CA, KRAS
238.7CTNNB1, AKT1, RRAS2
24
Show member pathways
VEGFR1 specific signals37
8.7PIK3CA, CTNNB1, AKT1
25
Show member pathways
Development A2B receptor action via G protein alpha s59
8.7CTNNB1, AKT1, PIK3CA
268.7AKT1, PIK3CA, CTNNB1
278.7CTNNB1, AKT1, PIK3CA
28
Show member pathways
Development A1 receptor signaling59
G protein signaling G Protein alpha q signaling cascades59
8.7CTNNB1, AKT1, PIK3CA
29
Show member pathways
8.7PIK3CA, AKT1, KRAS, RRAS2
308.6CTNNB1, AKT1, BRCA1
318.6CTNNB1, BRCA1, AKT1
328.6KRAS, ERBB2, BRCA1, PIK3CA
338.6BRCA1, PIK3CA, KRAS, AKT1
34
Show member pathways
8.4CTNNB1, RRAS2, KRAS, AKT1
358.4RRAS2, AKT1, KRAS, CTNNB1
36
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
8.4PIK3CA, AKT1, CTNNB1, KRAS
378.4KRAS, AKT1, PIK3CA, CTNNB1
38
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
8.3AKT1, CTNNB1, ERBB2, PIK3CA
398.3BRCA1, AKT1, KRAS, CTNNB1
40
Show member pathways
Signal transduction PTEN pathway59
8.0CTNNB1, KRAS, ERBB2, AKT1, PIK3CA
41
Show member pathways
8.0CTNNB1, AKT1, PIK3CA, KRAS, ERBB2
428.0AKT1, ERBB2, KRAS, CTNNB1, PIK3CA
43
Show member pathways
7.9AKT1, PARK2, ERBB2, PIK3CA, KRAS, BRCA1
44
Show member pathways
7.9CTNNB1, KRAS, AKT1, PIK3CA, RRAS2
457.9PIK3CA, RRAS2, AKT1, CTNNB1, KRAS
46
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
7.8CTNNB1, PIK3CA, RRAS2, AKT1, ERBB2
47
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
7.8RRAS2, AKT1, ERBB2, PIK3CA, CTNNB1
487.5PIK3CA, RRAS2, AKT1, ERBB2, KRAS, CTNNB1
49
Show member pathways
Signaling Pathways in Glioblastoma37
7.4ERBB2, KRAS, AKT1, PIK3CA, BRCA1, CTNNB1
507.4BRCA1, CTNNB1, KRAS, PIK3CA, ERBB2, AKT1

Compounds for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Compounds related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1erlotinib44 50 1211.5KRAS, ERBB2, PIK3CA
2everolimus44 50 1211.5ERBB2, PIK3CA, AKT1
3oxaliplatin44 50 1211.4KRAS, ERBB2, BRCA1
4cetuximab44 50 1211.3KRAS, ERBB2, CTNNB1
5carboplatin44 50 1211.2BRCA1, AKT1, ERBB2
6crcs449.1CTNNB1, PIK3CA, KRAS
7gemcitabine44 50 1211.1BRCA1, ERBB2, AKT1
8celecoxib44 60 29 50 25 1214.0ERBB2, CTNNB1, AKT1
9trastuzumab44 50 1211.0ERBB2, CTNNB1, PIK3CA
10indole-3-carbinol448.9CTNNB1, AKT1, BRCA1
11geldanamycin44 50 60 1211.9PARK2, CTNNB1, ERBB2
12etoposide44 50 60 1211.8AKT1, BRCA1, PIK3CA, ERBB2
13ag 1478448.8PIK3CA, AKT1, ERBB2, CTNNB1
14imatinib44 50 1210.8KRAS, CTNNB1, ERBB2, PIK3CA
15p002448.7KRAS, CTNNB1, ERBB2, BRCA1
16nmda44 299.7PARK2, PIK3CA, CTNNB1, AKT1
17mg 13244 609.7CTNNB1, BRCA1, PARK2, AKT1
184-hydroxytamoxifen448.7ERBB2, AKT1, CTNNB1, BRCA1
19adriamycin448.6AKT1, CTNNB1, ERBB2, BRCA1
20glycogen44 259.6PARK2, CTNNB1, AKT1, PIK3CA
21adpribose448.5CTNNB1, BRCA1, PIK3CA
22resveratrol44 60 25 1211.5PIK3CA, BRCA1, CTNNB1, ERBB2
23phosphoinositide448.5CTNNB1, KRAS, AKT1, PARK2, PIK3CA
24gefitinib44 50 1210.4CTNNB1, KRAS, AKT1, PIK3CA, ERBB2
25phosphotyrosine448.4PIK3CA, CTNNB1, ERBB2, BRCA1
26rapamycin448.4ERBB2, PIK3CA, KRAS, AKT1, CTNNB1
27ly294002448.4CTNNB1, KRAS, PIK3CA, ERBB2, AKT1
28wortmannin448.4AKT1, PIK3CA, KRAS, CTNNB1, ERBB2
29guanine44 25 1210.4BRCA1, CTNNB1, PARK2, ERBB2, AKT1
30nocodazole44 129.3AKT1, BRCA1, CTNNB1
31paraffin448.3KRAS, CTNNB1, ERBB2, AKT1, BRCA1
325fluorouracil448.2PIK3CA, CTNNB1, BRCA1, KRAS, ERBB2
33alanine448.1AKT1, BRCA1, CTNNB1, ERBB2, PARK2
34tamoxifen44 50 29 1211.1CTNNB1, AKT1, BRCA1, PIK3CA, ERBB2
35steroid448.1PIK3CA, PARK2, ERBB2, CTNNB1, BRCA1
36threonine448.1AKT1, CTNNB1, PIK3CA, PARK2, RRAS2
37doxorubicin44 50 1210.1ERBB2, BRCA1, PIK3CA, AKT1, CTNNB1
38genistein44 29 60 3 25 1213.1CTNNB1, ERBB2, AKT1, BRCA1, PIK3CA
39gtp44 299.0PIK3CA, RRAS2, PARK2, AKT1, KRAS, CTNNB1
40testosterone44 60 25 1210.8CTNNB1, AKT1, ERBB2, PARK2, BRCA1, PIK3CA
41retinoic acid44 258.8PIK3CA, BRCA1, AKT1, CTNNB1, KRAS
42cisplatin44 50 60 1210.8CTNNB1, KRAS, ERBB2, BRCA1, PIK3CA, AKT1
43phosphatidylinositol447.8ERBB2, AKT1, CTNNB1, KRAS, BRCA1, PIK3CA
44agar447.7PIK3CA, CTNNB1, ERBB2, AKT1, BRCA1, RRAS2
45paclitaxel44 50 129.5CTNNB1, ERBB2, KRAS, PARK2, BRCA1, AKT1
46h2o2447.5PARK2, CTNNB1, ERBB2, AKT1, BRCA1, PIK3CA
47vegf447.5PIK3CA, CTNNB1, BRCA1, AKT1, ERBB2, KRAS
48estrogen447.5CTNNB1, KRAS, ERBB2, AKT1, PARK2, BRCA1
49serine447.0PARK2, AKT1, BRCA1, PIK3CA, CTNNB1, ERBB2
50tyrosine447.0BRCA1, CTNNB1, PIK3CA, PARK2, AKT1, RRAS2

GO Terms for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Cellular components related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058866.5CTNNB1, OPCML, KRAS, ERBB2, AKT1, BRCA1

Biological processes related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1striated muscle cell differentiationGO:05114610.0KRAS, AKT1
2negative regulation of release of cytochrome c from mitochondriaGO:0902019.9AKT1, PARK2
3positive regulation of nitric-oxide synthase activityGO:0510009.9KRAS, AKT1
4protein kinase B signalingGO:0434919.7AKT1, PIK3CA
5positive regulation of protein phosphorylationGO:0019349.6KRAS, ERBB2, AKT1
6protein autoubiquitinationGO:0518659.6PARK2, BRCA1
7negative regulation of neuron apoptotic processGO:0435249.6PIK3CA, PARK2, KRAS
8positive regulation of peptidyl-serine phosphorylationGO:0331389.5AKT1, PIK3CA
9positive regulation of MAP kinase activityGO:0434069.5KRAS, ERBB2
10regulation of angiogenesisGO:0457659.4ERBB2, CTNNB1
11insulin receptor signaling pathwayGO:0082869.4PIK3CA, AKT1, KRAS
12phosphatidylinositol-mediated signalingGO:0480159.4ERBB2, AKT1, PIK3CA
13cellular response to indole-3-methanolGO:0716819.3BRCA1, CTNNB1
14fibroblast growth factor receptor signaling pathwayGO:0085439.2KRAS, ERBB2, AKT1, PIK3CA
15Fc-epsilon receptor signaling pathwayGO:0380959.2PIK3CA, AKT1, ERBB2, KRAS
16epidermal growth factor receptor signaling pathwayGO:0071739.1KRAS, ERBB2, AKT1, PIK3CA
17protein ubiquitinationGO:0165679.1BRCA1, PARK2, AKT1
18neurotrophin TRK receptor signaling pathwayGO:0480119.1KRAS, ERBB2, AKT1, PIK3CA
19androgen receptor signaling pathwayGO:0305218.9CTNNB1, BRCA1
20innate immune responseGO:0450878.3PIK3CA, AKT1, ERBB2, KRAS, CTNNB1

Molecular functions related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinase activityGO:0163019.4AKT1, PIK3CA
2kinase bindingGO:0199009.4CTNNB1, PARK2
3androgen receptor bindingGO:0506818.7CTNNB1, BRCA1
4enzyme bindingGO:0198998.6BRCA1, AKT1, CTNNB1
5protein bindingGO:0055156.2CTNNB1, PIK3CA, RRAS2, BRCA1, PARK2, PALB2

Products for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet