MCID: ADN034
MIFTS: 28

Adenocarcinoma, Ovarian, Somatic malady

Genetic diseases (common) category
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Summaries for Adenocarcinoma, Ovarian, Somatic

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47OMIM, 33MalaCards
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MalaCards: Adenocarcinoma, Ovarian, Somatic is related to fanconi's anemia and ovarian cancer, somatic. An important gene associated with Adenocarcinoma, Ovarian, Somatic is PARK2 (parkin RBR E3 ubiquitin protein ligase), and among its related pathways are Integrated Pancreatic Cancer Pathway and Glioma. The compounds colchicine and lactacystin have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and respiratory system.

Description from OMIM:47 167000

Aliases & Classifications for Adenocarcinoma, Ovarian, Somatic

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47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

adenocarcinoma, ovarian, somatic 47


Related Diseases for Adenocarcinoma, Ovarian, Somatic

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17GeneCards, 18GeneDecks
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Diseases related to Adenocarcinoma, Ovarian, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1fanconi's anemia10.0PARK2, BRCA1
2ovarian cancer, somatic10.0OPCML, CTNNB1
3familial adenomatous polyposis10.0CTNNB1, BRCA1
4lung adenocarcinoma10.0CTNNB1, PARK2
5endometrial carcinoma9.9CTNNB1, BRCA1
6breast cancer9.9CTNNB1, PARK2, BRCA1
7ovarian cancer9.9CTNNB1, OPCML, PARK2, BRCA1

Graphical network of diseases related to Adenocarcinoma, Ovarian, Somatic:



Diseases related to adenocarcinoma, ovarian, somatic

Symptoms for Adenocarcinoma, Ovarian, Somatic

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47OMIM
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Clinical features from OMIM:

167000

Drugs & Therapeutics for Adenocarcinoma, Ovarian, Somatic

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Adenocarcinoma, Ovarian, Somatic

Search NIH Clinical Center for Adenocarcinoma, Ovarian, Somatic

Genetic Tests for Adenocarcinoma, Ovarian, Somatic

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Anatomical Context for Adenocarcinoma, Ovarian, Somatic

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Animal Models for Adenocarcinoma, Ovarian, Somatic or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Adenocarcinoma, Ovarian, Somatic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.7CTNNB1, OPCML, PARK2
2MP:00053888.5CTNNB1, PARK2, BRCA1
3MP:00107718.5CTNNB1, PARK2, BRCA1
4MP:00053698.4BRCA1, PARK2, CTNNB1
5MP:00053908.2CTNNB1, PARK2, BRCA1

Publications for Adenocarcinoma, Ovarian, Somatic

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Variations for Adenocarcinoma, Ovarian, Somatic

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64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

64
id Symbol AA change Variation ID SNP ID
1BRCA1p.Cys61GlyVAR_007757rs28897672
2BRCA1p.Cys1697ArgVAR_020702
3BRCA1p.Arg1699TrpVAR_020703
4CTNNB1p.Ser37CysVAR_017625
5CTNNB1p.Thr41IleVAR_017630
6OPCMLp.Pro95ArgVAR_055421

Clinvar genetic disease variations for Adenocarcinoma, Ovarian, Somatic:

1
id Gene Name Type Significance SNP ID Assembly Location
1CDH1NM_004360.3(CDH1): c.2512A> G (p.Ser838Gly)single nucleotide variantLikely benign, Pathogenic, Uncertain significancers121964872GRCh37Chr 16, 68867265: 68867265
2KRASNM_033360.3(KRAS): c.34G> A (p.Gly12Ser)single nucleotide variantPathogenic, drug responsers121913530GRCh37Chr 12, 25398285: 25398285
3PALB2NM_024675.3(PALB2): c.1050_1053delAACA (p.Thr351Argfs)deletionPathogenicrs515726060GRCh38Chr 16, 23635493: 23635496
4ERBB2NM_001005862.2(ERBB2): c.2480A> G (p.Asn827Ser)single nucleotide variantPathogenicrs28933370GRCh37Chr 17, 37881378: 37881378
5AKT1NM_001014431.1(AKT1): c.49G> A (p.Glu17Lys)single nucleotide variantPathogenicrs121434592GRCh37Chr 14, 105246551: 105246551
6CTNNB1NM_001904.3(CTNNB1): c.110C> G (p.Ser37Cys)single nucleotide variantLikely pathogenic, Pathogenicrs121913403GRCh37Chr 3, 41266113: 41266113
7PARK2PARK2, DELdeletionPathogenic
8OPCMLNM_001012393.1(OPCML): c.263C> G (p.Pro88Arg)single nucleotide variantPathogenicrs137852691GRCh37Chr 11, 132527098: 132527098
9RRAS2NM_001177314.1(RRAS2): c.110A> T (p.Gln37Leu)single nucleotide variantPathogenicrs113954997GRCh37Chr 11, 14316390: 14316390

Expression for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenocarcinoma, Ovarian, Somatic

Search GEO for disease gene expression data for Adenocarcinoma, Ovarian, Somatic.

Pathways for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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50PathCards, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0CTNNB1, BRCA1
2
Show member pathways
Signaling Pathways in Glioblastoma38
9.0CTNNB1, BRCA1
39.0BRCA1, CTNNB1
49.0CTNNB1, BRCA1
59.0CTNNB1, BRCA1

Compounds for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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Sources:
45Novoseek, 61Tocris Bioscience, 3BitterDB, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1colchicine45 61 3 29 1113.7BRCA1, PARK2
2lactacystin459.6PARK2, BRCA1
3geldanamycin45 51 61 1112.5CTNNB1, PARK2
4sodium bisulfite459.4BRCA1, CTNNB1
5indole-3-carbinol459.4BRCA1, CTNNB1
6leptomycin b45 6110.4BRCA1, CTNNB1
74-hydroxytamoxifen459.4BRCA1, CTNNB1
8bleomycin45 1110.4BRCA1, CTNNB1
9adpribose459.4BRCA1, CTNNB1
10nocodazole45 1110.4CTNNB1, BRCA1
11linoleic acid29 45 2411.3BRCA1, CTNNB1
12p002459.3CTNNB1, BRCA1
13resveratrol45 61 24 1112.3CTNNB1, BRCA1
14adriamycin459.3BRCA1, CTNNB1
155-aza-2deoxycytidine459.2CTNNB1, BRCA1
16glycerol45 24 1111.2CTNNB1, BRCA1
175fluorouracil459.2BRCA1, CTNNB1
18agar459.1CTNNB1, BRCA1
19phosphotyrosine459.1BRCA1, CTNNB1
20tamoxifen45 51 29 1111.9BRCA1, CTNNB1
21mg 13245 619.9CTNNB1, PARK2, BRCA1
22guanine45 24 1110.9CTNNB1, PARK2, BRCA1
23paclitaxel45 51 1110.9CTNNB1, PARK2, BRCA1
24glutamine458.9BRCA1, PARK2, CTNNB1
25lysine458.9CTNNB1, PARK2, BRCA1
26h2o2458.9CTNNB1, PARK2, BRCA1
27testosterone45 61 24 1111.9CTNNB1, PARK2, BRCA1
28steroid458.9BRCA1, PARK2, CTNNB1
29oligonucleotide458.9CTNNB1, PARK2, BRCA1
30vegf458.9CTNNB1, PARK2, BRCA1
31alanine458.9CTNNB1, PARK2, BRCA1
32nmda45 299.8CTNNB1, PARK2
33estrogen458.8BRCA1, PARK2, CTNNB1
34atp45 299.8CTNNB1, PARK2, BRCA1
35cysteine458.8BRCA1, PARK2, CTNNB1
36serine458.5CTNNB1, PARK2, BRCA1
37tyrosine458.5CTNNB1, PARK2, BRCA1

GO Terms for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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16Gene Ontology
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Cellular components related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin ligase complexGO:0001519.3PARK2, BRCA1

Biological processes related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein autoubiquitinationGO:0518659.3PARK2, BRCA1
2protein ubiquitinationGO:0165679.3PARK2, BRCA1
3cellular response to indole-3-methanolGO:0716819.1CTNNB1, BRCA1
4androgen receptor signaling pathwayGO:0305218.9BRCA1, CTNNB1
5positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431238.8CTNNB1, PARK2

Molecular functions related to Adenocarcinoma, Ovarian, Somatic according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:0316259.4PARK2, BRCA1
2kinase bindingGO:0199009.3CTNNB1, PARK2
3androgen receptor bindingGO:0506819.2CTNNB1, BRCA1
4protein kinase bindingGO:0199019.1CTNNB1, PARK2
5transcription regulatory region DNA bindingGO:0442129.1CTNNB1, BRCA1
6transcription coactivator activityGO:0037139.0BRCA1, CTNNB1
7ubiquitin-protein ligase activityGO:0048429.0PARK2, BRCA1
8enzyme bindingGO:0198998.9CTNNB1, BRCA1

Products for genes affiliated with Adenocarcinoma, Ovarian, Somatic

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  • Antibodies
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Sources for Adenocarcinoma, Ovarian, Somatic

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet