MCID: ADN017
MIFTS: 41

Adenofibroma malady

Cancer diseases category
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Summaries for Adenofibroma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A cell type benign neoplasm that is composed of glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards: Adenofibroma, also known as adenofibroma, no icd-o subtype, is related to adenocarcinoma and adenosarcoma. An important gene associated with Adenofibroma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways are Peptide hormone metabolism and Ovarian Infertility Genes. The compounds 3beta-hydroxysteroid and crcs have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and uterus, and related mouse phenotypes are immune system and normal.

Aliases & Classifications for Adenofibroma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenofibroma 8 10 45 62
adenofibroma, no icd-o subtype 8


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Disease Ontology8 DOID:2683
MeSH35 D000232
SNOMED-CT58 189823009, 2962009
NCIt40 C8984

Related Diseases for Adenofibroma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Adenofibroma family:

Malignant Adenofibroma

Diseases related to Adenofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.3CALB2, MME, MUC16, PGR, PTEN, INHA
2adenosarcoma30.3MME, PGR
3wilms tumor30.3CALB2, MME, INHA
4endometriosis30.3PTEN, PGR, MUC16, CALB2, ARID1A
5breast cancer30.1INHA, PTEN, PGR, MUC16, MME
6cystadenoma30.0INHA, MME
7endometrial stromal sarcoma29.9INHA, PGR, MME
8endometrial carcinoma29.8MME, MUC16, PGR, PTEN
9clear cell adenofibroma10.5
10papillary adenofibroma10.5
11nephrogenic adenofibroma10.4
12cystadenofibroma10.3
13ovarian clear cell adenofibroma10.3
14mucinous adenofibroma10.2
15cervical adenofibroma10.2
16uterine corpus adenofibroma10.2
17clear cell adenocarcinoma10.2
18malignant adenofibroma10.2
19ovarian endometrioid adenofibroma10.2
20ovarian mucinous adenofibroma10.2
21fallopian tube adenofibroma10.2
22ovarian serous adenofibroma10.2
23malignant peritoneal mesothelioma10.1CALB2
24cystadenocarcinoma10.1MUC16
25ovarian serous cystadenocarcinoma10.1MUC16
26proteus syndrome10.1PTEN
27ovarian clear cell malignant adenofibroma10.1
28ovarian mucinous malignant adenofibroma10.1
29ovarian endometrioid malignant adenofibroma10.1
30giant adenofibroma of the breast10.1
31sex cord-gonadal stromal tumor10.1CALB2, INHA
32granular cell tumor10.1CALB2, INHA
33endodermal sinus tumor10.1INHA, MUC16
34epithelioid sarcoma10.1MUC16, CALB2
35leydig cell tumor10.1CALB2, INHA
36fibroma10.1CALB2, MUC16
37adrenocortical carcinoma10.1INHA, CALB2
38malignant pleural mesothelioma10.0CALB2, MUC16
39pulmonary tuberculosis10.0MUC16, INHA
40adrenal adenoma10.0CALB2, INHA
41peutz-jeghers syndrome10.0PTEN, INHA
42neurilemmoma10.0CALB2, INHA
43malignant mesothelioma10.0MUC16, CALB2
44abrikosov's tumor10.0CALB2, MUC16, INHA
45gynecomastia10.0INHA, PGR
46benign mesothelioma10.0CALB2, MUC16
47seminoma10.0CALB2, INHA
48malignant mixed mullerian tumor10.0PGR, MME
49phyllode tumor10.0MME, PGR
50congestive heart failure10.0MME, MUC16

Graphical network of the top 20 diseases related to Adenofibroma:



Diseases related to adenofibroma

Symptoms for Adenofibroma

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Drugs & Therapeutics for Adenofibroma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Adenofibroma

Search NIH Clinical Center for Adenofibroma

Genetic Tests for Adenofibroma

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Anatomical Context for Adenofibroma

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33MalaCards
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MalaCards organs/tissues related to Adenofibroma:

33
Ovary, Cervix, Uterus, Lung, Breast, Testis, Liver, Kidney, Thyroid

Animal Models for Adenofibroma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Adenofibroma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2MAF, MME, PGR, PTEN, INHA
2MP:00028737.6ARID1A, CALB2, PGR, PTEN, INHA
3MP:00053767.4INHA, PTEN, PGR, MME, MAF, ARID1A

Publications for Adenofibroma

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52PubMed
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Articles related to Adenofibroma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI. (24172789)
2013
2
Metanephric adenofibroma. (23587517)
2013
3
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. (23153077)
2013
4
Adenofibroma of the uterine cervix coexistent with endometriosis. (22795111)
2012
5
Unusual presentation of rare case of papillary adenofibroma of cervix in a young woman. (22606457)
2012
6
Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. (21479128)
2011
7
Clear cell adenocarcinoma arising in endometrial adenofibroma. (21355961)
2011
8
Serous adenofibroma of the testicle: case report and review of the literature. (20040787)
2010
9
Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. (20890073)
2010
10
Biliary adenofibroma of the liver: report of a case and review of the literature. (21151526)
2010
11
Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)
2009
12
Adenofibroma of the testis. (19474357)
2009
13
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. (19655165)
2009
14
Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma. (18580316)
2008
15
Benign clear cell adenofibroma of the ovary. A case report with literature review. (17202822)
2007
16
Endometrial adenofibroma: a rare entity. (16858575)
2007
17
Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)
2006
18
Fine-needle aspiration cytology of endometrioid adenofibroma of the ovary. (15236263)
2004
19
Adenofibroma of the testis discovered at exploration for torsion after trauma. (14532817)
2003
20
Paratesticular adenofibroma. (12745730)
2003
21
Uterine cervical adenofibroma associated with Turner's syndrome in a young woman. (12410376)
2002
22
Nephrogenic adenofibroma in a young child. (11156329)
2000
23
Metanephric adenofibroma: report of a case and review of the literature. (10366157)
1999
24
Sonographic characteristics of adenofibroma of the endometrium following tamoxifen therapy for breast cancer: two case reports. (8774105)
1996
25
Papillary adenofibroma of the uterine cervix. A case report. (8927449)
1996
26
An unusual endometrioid adenofibroma of the uterine cervix: a histologic and immunohistochemical study. (11578483)
1995
27
Significant increases in serum CA125 and CA19-9 following torsion from an adenofibroma of the ovary: a case report. (8158859)
1994
28
Biliary adenofibroma. A heretofore unrecognized benign biliary tumor of the liver. (8422113)
1993
29
Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. (8314238)
1993
30
Uterine adenofibroma mimicking endometrial carcinoma: MR findings. (1727352)
1992
31
Nephrogenic adenofibroma. A novel kidney tumor of young people. (1373578)
1992
32
Adenofibroma of the uterus: multiple recurrences following wide local excision. (2351327)
1990
33
MA1llerian adenofibroma of the uterus with invasion of myometrium and pelvic veins. (2246094)
1990
34
Ovarian clear cell adenofibroma of borderline malignancy. A case report. (2793520)
1989
35
Invasive ovarian endometrioid adenofibroma with omental implants and collision with endometrial adenocarcinoma. (3347431)
1988
36
Adenofibroma of the rete testis. A case report with electron microscopy findings. (3364196)
1988
37
Malignant endometrioid adenofibroma of the ovary with serous cystadenoma. (3728014)
1986
38
MA1llerian adenofibroma. Case report. (6518157)
1984
39
Papillary adenofibroma of the endometrium: case report and review of the literature. (6489832)
1984
40
Bilateral papillary adenofibroma of the fallopian tube. (7468528)
1981
41
Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. (6263458)
1981
42
Cystadenofibroma, adenofibroma, and malignant adenofibroma of the ovary. (917592)
1977
43
Papillary adenofibroma of the uterus: a benign mesodermal mixed tumor of MA1llerian orgin. (4364374)
1973
44
Papillary adenofibroma of the uterine cervix. (5558981)
1971
45
Adenofibroma of urinary bladder: a case report. (13131417)
1953
46
Adenofibroma of ovary with partial differentiation to endometriosis. (18125052)
1949
47
Effect of dibenzanthracene on transplantable mammary adenofibroma of the white rat. (19970548)
1941
48
The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats. (12279175)
1940
49
Tumour of the Ovary.A ? Adenofibroma or Endothelioma. (20898235)
1909
50
Tumour of the Ovary. ? Adenofibroma or Endothelioma. (19973838)
1909

Variations for Adenofibroma

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Expression for genes affiliated with Adenofibroma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenofibroma

Search GEO for disease gene expression data for Adenofibroma.

Pathways for genes affiliated with Adenofibroma

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50PathCards, 55Reactome, 38NCBI BioSystems Database
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Pathways related to Adenofibroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7MME, INHA
29.6PGR, INHA

Compounds for genes affiliated with Adenofibroma

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45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Adenofibroma according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid459.6PGR, INHA
2crcs459.6MME, PTEN
3taxane459.6PGR, PTEN
4gnrh459.5INHA, PGR, MME
5diethylstilbestrol45 29 1111.4PGR, PTEN
6ribonucleic acid459.4MME, PGR, INHA
7b 723459.3MUC16, CALB2
8trastuzumab45 51 1111.2PGR, PTEN
9cyclophosphamide45 51 1111.1MUC16, PGR, PTEN
10fatty acid459.1INHA, PTEN, MME
11cycloheximide458.9MME, PGR, PTEN
12hyaluronic acid45 249.8PTEN, MUC16, CALB2
13leucine458.8MAF, MME, PTEN
14estradiol45 24 1110.7MUC16, PGR, PTEN, INHA
15glucose458.7PTEN, MUC16, MME, MAF
16doxorubicin45 51 1110.7PTEN, PGR, MUC16, MME
17vegf458.7MME, MUC16, PGR, PTEN
18hematoxylin458.5INHA, PTEN, MUC16, CALB2
19paclitaxel45 51 1110.3PTEN, PGR, MUC16, CALB2
20tyrosine458.0INHA, PTEN, MUC16, MME, CALB2
21paraffin457.6CALB2, MME, MUC16, PGR, PTEN, INHA
22progesterone45 29 61 24 1111.6INHA, PTEN, PGR, MUC16, MME, CALB2
23testosterone45 61 24 1110.6INHA, PTEN, PGR, MUC16, MME, CALB2
24steroid457.5INHA, PTEN, PGR, MUC16, MME, CALB2
25estrogen457.5INHA, PTEN, PGR, MUC16, MME, CALB2

GO Terms for genes affiliated with Adenofibroma

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16Gene Ontology
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Molecular functions related to Adenofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.2ARID1A, MME, MUC16, PGR, PTEN, SHFM1

Products for genes affiliated with Adenofibroma

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Sources for Adenofibroma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet