Adenofibroma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Adenofibroma

Sources:
⁹Disease Ontology, ³²MalaCards
See all sources

Disease Ontology:⁹ A cell type benign neoplasm that is composed of glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards based summary: Adenofibroma, also known as adenofibroma, no icd-o subtype, is related to adenosarcoma and wilms tumor. An important gene associated with Adenofibroma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways are Peptide hormone metabolism and Ovarian Infertility Genes. The compounds 3beta-hydroxysteroid and crcs have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and uterus, and related mouse phenotypes are immune system and normal.

Aliases & Classifications for Adenofibroma

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁴⁴Novoseek, ⁶¹UMLS, ³⁴MeSH, ⁵⁶SNOMED-CT, ³⁹NCIt
See all sources

Adenofibroma, Aliases & Descriptions:

Name: Adenofibroma ⁹ ¹¹ ⁴⁴ ⁶¹

Adenofibroma, No Icd-O Subtype ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases

External Ids:

Disease Ontology⁹ DOID:2683

MeSH³⁴ D000232

SNOMED-CT⁵⁶ 189823009, 2962009

NCIt³⁹ C8984

UMLS⁶¹ C0001422

Related Diseases for Adenofibroma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Adenofibroma family:

Malignant Adenofibroma

Diseases related to Adenofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 80)

id	Related Disease	Score	Top Affiliating Genes
1	adenosarcoma	30.4	MME, PGR
2	wilms tumor	30.4	MME, CALB2, INHA
3	cystadenoma	30.3	MME, INHA
4	endometrial stromal sarcoma	29.8	PGR, MME, INHA
5	endometriosis	29.7	CALB2, PTEN, ARID1A, MUC16, PGR
6	adenocarcinoma	29.5	INHA, PTEN, PGR, MUC16, MME, CALB2
7	endometrial carcinoma	29.4	PTEN, MME, MUC16, PGR
8	breast cancer	29.3	MUC16, PGR, MME, PTEN, INHA
9	papillary adenofibroma	10.5
10	clear cell adenofibroma	10.5
11	malignant peritoneal mesothelioma	10.4	CALB2
12	cystadenocarcinoma	10.4	MUC16
13	ovarian serous cystadenocarcinoma	10.4	MUC16
14	proteus syndrome	10.4	PTEN
15	nephrogenic adenofibroma	10.4
16	cystadenofibroma	10.3
17	sex cord-gonadal stromal tumor	10.3	INHA, CALB2
18	uterine corpus adenofibroma	10.3
19	malignant adenofibroma	10.3
20	ovarian clear cell adenofibroma	10.3
21	granular cell tumor	10.3	INHA, CALB2
22	endodermal sinus tumor	10.3	MUC16, INHA
23	epithelioid sarcoma	10.3	CALB2, MUC16
24	mucinous adenofibroma	10.3
25	cervical adenofibroma	10.3
26	clear cell adenocarcinoma	10.3
27	ovarian endometrioid adenofibroma	10.3
28	ovarian mucinous adenofibroma	10.3
29	leydig cell tumor	10.2	CALB2, INHA
30	fibroma	10.2	CALB2, MUC16
31	adrenocortical carcinoma	10.2	INHA, CALB2
32	malignant pleural mesothelioma	10.2	CALB2, MUC16
33	pulmonary tuberculosis	10.2	INHA, MUC16
34	adrenal cortical adenoma	10.2	INHA, CALB2
35	peutz-jeghers syndrome	10.2	INHA, PTEN
36	ovarian clear cell malignant adenofibroma	10.2
37	ovarian mucinous malignant adenofibroma	10.2
38	ovarian endometrioid malignant adenofibroma	10.2
39	fallopian tube adenofibroma	10.2
40	ovarian serous adenofibroma	10.2
41	neurilemmoma	10.2	CALB2, INHA
42	abrikosov's tumor	10.1	INHA, CALB2, MUC16
43	giant adenofibroma of the breast	10.1
44	gynecomastia	10.1	INHA, PGR
45	malignant mesothelioma	10.1	MUC16, CALB2
46	seminoma	10.1	CALB2, INHA
47	malignant mixed mullerian tumor	10.1	MME, PGR
48	phyllode tumor	10.1	PGR, MME
49	congestive heart failure	10.0	MME, MUC16
50	tubular adenocarcinoma	10.0	MME, PGR

Graphical network of the top 20 diseases related to Adenofibroma:

Symptoms for Adenofibroma

Drugs & Therapeutics for Adenofibroma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Adenofibroma

Search NIH Clinical Center for Adenofibroma

Genetic Tests for Adenofibroma

Anatomical Context for Adenofibroma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Adenofibroma:

³²

Ovary, Cervix, Uterus, Lung, Testis, Liver, Breast, Kidney, Thyroid

Animal Models for Adenofibroma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Adenofibroma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.2	MAF, MME, PGR, PTEN, INHA
2	normal phenotype	MP:0002873	7.6	ARID1A, CALB2, PGR, PTEN, INHA
3	homeostasis/metabolism phenotype	MP:0005376	7.4	INHA, PTEN, PGR, MME, MAF, ARID1A

Publications for Adenofibroma

Sources:
⁵¹PubMed
See all sources

Articles related to Adenofibroma:

(show top 50) (show all 97)

id	Title	Authors	Year
1	Serous surface papillary adenofibroma of the ovary: impersonator of ovarian malignancy. (24484475)	Ulker V.... Bakir B.	2014
2	Pulmonary adenofibroma: clinicopathological study of 3 cases of a rare benign lung lesion and review of the literature. (24908371)	Kumar R.... Jambhekar N.A.	2014
3	Adenofibroma in a young patient: a rare entity in an uncommon age. (24459594)	Maciel R.... Areias M.J.	2013
4	Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI. (24172789)	Takeuchi M.... Harada M.	2013
5	Metanephric adenofibroma. (23587517)	Turner Ii R.M.... Cannon G.M.	2013
6	Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. (23153077)	Chen R.... Zhang Y.	2013
7	Adenofibroma of the uterine cervix coexistent with endometriosis. (22795111)	Chu I.L.... Hsu C.S.	2012
8	Unusual presentation of rare case of papillary adenofibroma of cervix in a young woman. (22606457)	Navada H.M.... Jayaprakash C.S.	2012
9	Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. (21479128)	Zhao C.... Barner R.	2011
10	Clear cell adenocarcinoma arising in endometrial adenofibroma. (21355961)	Mikami S.... Mukai M.	2011
11	Serous adenofibroma of the testicle: case report and review of the literature. (20040787)	Subhawong T.K.... Hamper U.M.	2010
12	Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. (20890073)	Liu J.L.... Huang R.H.	2010
13	Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)	Gallardo A.... Prat J.	2009
14	Adenofibroma of the testis. (19474357)	Gatt N.... Degaetano J.	2009
15	An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. (19655165)	Yamamoto S.... Matsubara O.	2009
16	Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma. (18580316)	Bossuyt V.... Nucci M.R.	2008
17	Benign clear cell adenofibroma of the ovary. A case report with literature review. (17202822)	PaA9aoA9lu O.... Acikalin M.F.	2007
18	Endometrial adenofibroma: a rare entity. (16858575)	Bettaieb I.... Zitouna M.	2007
19	Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)	Hayasaka K.... Tanaka Y.	2006
20	Fine-needle aspiration cytology of endometrioid adenofibroma of the ovary. (15236263)	Volmar K.E.... Creager A.J.	2004
21	Adenofibroma of the testis discovered at exploration for torsion after trauma. (14532817)	Rogers C.G.... Pavlovich C.P.	2003
22	Paratesticular adenofibroma. (12745730)	Janane A.... Abbar M.	2003
23	Uterine cervical adenofibroma associated with Turner's syndrome in a young woman. (12410376)	Ishiko O.... Ogita S.	2002
24	Nephrogenic adenofibroma in a young child. (11156329)	Guzman E.... Michiels J.F.	2000
25	Metanephric adenofibroma: report of a case and review of the literature. (10366157)	Shek T.W.... Chan G.C.	1999
26	Papillary adenofibroma of the uterine cervix. A case report. (8927449)	Fratini D.... Cavaliere A.	1996
27	An unusual endometrioid adenofibroma of the uterine cervix: a histologic and immunohistochemical study. (11578483)	Nishida T.... Yakushiji M.	1995
28	Significant increases in serum CA125 and CA19-9 following torsion from an adenofibroma of the ovary: a case report. (8158859)	Fujiwara K.... Kohno I.	1994
29	Biliary adenofibroma. A heretofore unrecognized benign biliary tumor of the liver. (8422113)	Tsui W.M.... Tse C.C.	1993
30	Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. (8314238)	Suster S.... Moran C.A.	1993
31	Uterine adenofibroma mimicking endometrial carcinoma: MR findings. (1727352)	Kaji Y.... Okizuka H.	1992
32	Nephrogenic adenofibroma. A novel kidney tumor of young people. (1373578)	Hennigar R.A.... Beckwith J.B.	1992
33	Adenofibroma of the uterus: multiple recurrences following wide local excision. (2351327)	Seltzer V.L.... Coffey E.L.	1990
34	MA1llerian adenofibroma of the uterus with invasion of myometrium and pelvic veins. (2246094)	Clement P.B.... Scully R.E.	1990
35	Ovarian clear cell adenofibroma of borderline malignancy. A case report. (2793520)	Katsube Y.... Fujiwara A.	1989
36	Invasive ovarian endometrioid adenofibroma with omental implants and collision with endometrial adenocarcinoma. (3347431)	Gaing A.A.... Tchertkoff V.	1988
37	Adenofibroma of the rete testis. A case report with electron microscopy findings. (3364196)	Murao T.... Tanahashi T.	1988
38	Malignant endometrioid adenofibroma of the ovary with serous cystadenoma. (3728014)	Iwasaki I.... Takahashi A.	1986
39	MA1llerian adenofibroma. Case report. (6518157)	Hilton P.... Watson A.	1984
40	Bilateral papillary adenofibroma of the fallopian tube. (7468528)	Chen K.T.	1981
41	Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. (6263458)	Zaloudek C.J.... Norris H.J.	1981
42	Cystadenofibroma, adenofibroma, and malignant adenofibroma of the ovary. (917592)	Czernobilsky B.	1977
43	Papillary adenofibroma of the uterus: a benign mesodermal mixed tumor of MA1llerian orgin. (4364374)	Vellios F.... Reagen J.W.	1973
44	Papillary adenofibroma of the uterine cervix. (5558981)	Abell M.R.	1971
45	Adenofibroma of urinary bladder: a case report. (13131417)	Levi M.... SOLOMON C.	1953
46	Adenofibroma of ovary with partial differentiation to endometriosis. (18125052)	Hughesdon P.E.	1949
47	Effect of dibenzanthracene on transplantable mammary adenofibroma of the white rat. (19970548)	Davis J.H.... Emge L.A.	1941
48	The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats. (12279175)	Mohs F.E.	1940
49	Tumour of the Ovary.A ? Adenofibroma or Endothelioma. (20898235)	Smith G.F.	1909
50	Tumour of the Ovary. ? Adenofibroma or Endothelioma. (19973838)	Smith G.F.	1909

Genes related to Adenofibroma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Adenofibroma:

- Elite gene

id	Symbol	Description	Score	Implication
1	SHFM1	split hand/foot malformation (ectrodactyly) type 1	21.16	GeneCards inferred via : Disorders (show sections)
2	MAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	18.91	GeneCards inferred via : Disorders (show sections)
3	INHA	inhibin, alpha	16.69	GeneCards inferred via : Disorders (show sections)
4	MME	membrane metallo-endopeptidase	14.41	GeneCards inferred via : Publications (show sections)
5	ARID1A	AT rich interactive domain 1A (SWI-like)	12.19	GeneCards inferred via : Disorders (show sections)
6	PGR	progesterone receptor	9.96	GeneCards inferred via : Publications (show sections)
7	PTEN	phosphatase and tensin homolog	7.74	GeneCards inferred via : Publications (show sections)
8	CALB2	calbindin 2	5.58	GeneCards inferred via : Disorders (show sections)
9	MUC16	mucin 16, cell surface associated	3.35	GeneCards inferred via : Publications, Disorders (show sections)

Products for genes related to Adenofibroma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	8	-	8	8
2	Novus Biologicals	9	6	9	-

Variations for Adenofibroma

Expression for genes affiliated with Adenofibroma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Adenofibroma

Search GEO for disease gene expression data for Adenofibroma.

Pathways for genes affiliated with Adenofibroma

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Adenofibroma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Peptide hormone metabolism⁵⁴ Show member pathways Glycoprotein hormones⁵⁴ thyroid hormone biosynthesis³⁷ Insulin Processing⁵⁴ Metabolism of Angiotensinogen to Angiotensins⁵⁴ Synthesis, Secretion, and Deacylation of Ghrelin⁵⁴ Peptide hormone biosynthesis⁵⁴	9.7	MME, INHA
2	Ovarian Infertility Genes³⁷	9.6	PGR, INHA

Compounds for genes affiliated with Adenofibroma

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ¹²DrugBank, ⁵⁰PharmGKB, ²⁵HMDB, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Adenofibroma according to GeneCards/GeneDecks:

(show all 25)

id	Compound	Score	Top Affiliating Genes
1	3beta-hydroxysteroid⁴⁴	9.6	PGR, INHA
2	crcs⁴⁴	9.6	MME, PTEN
3	taxane⁴⁴	9.6	PGR, PTEN
4	gnrh⁴⁴	9.5	INHA, PGR, MME
5	diethylstilbestrol⁴⁴ ²⁹ ¹²	11.4	PGR, PTEN
6	ribonucleic acid⁴⁴	9.4	MME, PGR, INHA
7	b 723⁴⁴	9.3	MUC16, CALB2
8	trastuzumab⁴⁴ ⁵⁰ ¹²	11.2	PGR, PTEN
9	cyclophosphamide⁴⁴ ⁵⁰ ¹²	11.1	MUC16, PGR, PTEN
10	fatty acid⁴⁴	9.1	INHA, PTEN, MME
11	cycloheximide⁴⁴	8.9	MME, PGR, PTEN
12	hyaluronic acid⁴⁴ ²⁵	9.8	PTEN, MUC16, CALB2
13	leucine⁴⁴	8.8	MAF, MME, PTEN
14	estradiol⁴⁴ ²⁵ ¹²	10.7	MUC16, PGR, PTEN, INHA
15	glucose⁴⁴	8.7	PTEN, MUC16, MME, MAF
16	doxorubicin⁴⁴ ⁵⁰ ¹²	10.7	PTEN, PGR, MUC16, MME
17	vegf⁴⁴	8.7	MME, MUC16, PGR, PTEN
18	hematoxylin⁴⁴	8.5	INHA, PTEN, MUC16, CALB2
19	paclitaxel⁴⁴ ⁵⁰ ¹²	10.3	PTEN, PGR, MUC16, CALB2
20	tyrosine⁴⁴	8.0	INHA, PTEN, MUC16, MME, CALB2
21	paraffin⁴⁴	7.6	CALB2, MME, MUC16, PGR, PTEN, INHA
22	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	11.6	INHA, PTEN, PGR, MUC16, MME, CALB2
23	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	10.6	INHA, PTEN, PGR, MUC16, MME, CALB2
24	steroid⁴⁴	7.5	INHA, PTEN, PGR, MUC16, MME, CALB2
25	estrogen⁴⁴	7.5	INHA, PTEN, PGR, MUC16, MME, CALB2

GO Terms for genes affiliated with Adenofibroma

Sources:
¹⁷Gene Ontology
See all sources

Molecular functions related to Adenofibroma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	7.2	ARID1A, MME, MUC16, PGR, PTEN, SHFM1

Products for genes affiliated with Adenofibroma

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Adenofibroma

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: ADN017 MIFTS: 40	Adenofibroma malady Cancer diseases category
9 genes, 9 tissues, 80 related diseases, clinical trials Download this MalaCard Expand all tables

Adenofibroma malady