MCID: ADN017
MIFTS: 38

Adenofibroma malady

Summaries for Adenofibroma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A cell type benign neoplasm that is composed of glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards: Adenofibroma, also known as adenofibroma, no icd-o subtype, is related to adenocarcinoma and endometriosis. An important gene associated with Adenofibroma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways is Ovarian Infertility Genes. The compounds estrogen and taxane have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and uterus, and related mouse phenotypes are normal and integument.

Aliases & Classifications for Adenofibroma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

adenofibroma 8 10 44 60
adenofibroma, no icd-o subtype 8


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Disease Ontology8 DOID:2683
NCIt39 C8984
SNOMED-CT56 189823009, 2962009
MeSH34 D000232

Related Diseases for Adenofibroma

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17GeneCards, 18GeneDecks
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Diseases in the Adenofibroma family:

Malignant Adenofibroma

Diseases related to Adenofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.4INHA, MME, CALB2, MUC16, PTEN, PGR
2endometriosis30.3ARID1A, PTEN, PGR, MUC16, CALB2
3adenosarcoma30.1MME, PGR
4breast cancer30.1PTEN, MME, PGR, MUC16, INHA
5sarcoma29.8CALB2
6cystadenoma29.8MME, INHA
7endometrial stromal sarcoma29.8PGR, INHA, MME
8papillary carcinoma29.8MUC16, PGR, CALB2
9endometrial carcinoma29.8MUC16, MME, PGR, PTEN
10ovarian cancer29.8PTEN, PGR, CALB2, MUC16, INHA
11clear cell adenofibroma10.5
12papillary adenofibroma10.5
13malignant adenofibroma10.4
14ovarian clear cell adenofibroma10.4
15nephrogenic adenofibroma10.3
16fallopian tube adenofibroma10.3
17cystadenofibroma10.3
18uterine corpus adenofibroma10.2
19ovarian endometrioid adenofibroma10.2
20mucinous adenofibroma10.2
21clear cell adenocarcinoma10.2
22ovarian clear cell malignant adenofibroma10.2
23cervical adenofibroma10.2
24ovarian mucinous adenofibroma10.2
25ovarian endometriosis10.1
26endometriosis of ovary10.1
27ovarian serous adenofibroma10.1
28ovary adenocarcinoma10.1
29ovarian mucinous malignant adenofibroma10.0
30ovarian endometrioid malignant adenofibroma10.0
31endometrial adenocarcinoma10.0
32giant adenofibroma of the breast10.0
33chordoma10.0INHA
34angiosarcoma10.0CALB2
35cystadenocarcinoma10.0MUC16
36plasma cell leukemia10.0MAF
37malignant peritoneal mesothelioma10.0CALB2
38meigs syndrome10.0MUC16
39liposarcoma10.0CALB2
40obesity10.0INHA
41ovarian serous cystadenocarcinoma10.0MUC16
42asthma10.0MME
43peritonitis10.0MUC16
44congestive heart failure10.0MME
45dysgerminoma10.0INHA
46proteus syndrome10.0PTEN
47uterine sarcoma10.0MME
48leydig cell tumor10.0CALB2, INHA
49adenoma10.0INHA, CALB2
50rhabdomyosarcoma10.0INHA, CALB2

Graphical network of the top 20 diseases related to Adenofibroma:



Diseases related to adenofibroma

Clinical Features for Adenofibroma

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Drugs & Therapeutics for Adenofibroma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Adenofibroma

Drug clinical trials:

Search ClinicalTrials for Adenofibroma

Search NIH Clinical Center for Adenofibroma

Search CenterWatch for Adenofibroma

Genetic Tests for Adenofibroma

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Anatomical Context for Adenofibroma

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32MalaCards
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MalaCards organs/tissues related to Adenofibroma:

32
Ovary, Cervix, Uterus, Lung, Breast, Testis, Liver, Kidney, Thyroid

Animal Models for Adenofibroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenofibroma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1ARID1A, INHA, PGR, PTEN, CALB2
2MP:00107718.0PTEN, PAK4, MME, PGR, MAF

Publications for Adenofibroma

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50PubMed
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Articles related to Adenofibroma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Metanephric adenofibroma. (23587517)
2013
2
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. (23153077)
2013
3
A composite renal tumor: metanephric adenofibroma, Wilms tumor, and renal cell carcinoma: a missing link? (21711207)
2012
4
Clear cell adenocarcinoma arising in endometrial adenofibroma. (21355961)
2011
5
Serous adenofibroma of the testicle: case report and review of the literature. (20040787)
2010
6
Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)
2009
7
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. (19655165)
2009
8
Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma. (18580316)
2008
9
Benign clear cell adenofibroma of the ovary. A case report with literature review. (17202822)
2007
10
Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)
2006
11
Adenofibroma of the endometrium protruding into the vaginal cavity: findings on transvaginal ultrasonography, MRI and CT. (17100829)
2006
12
Pathologic quiz case: a 54-year-old woman with bilateral pelvic masses. Well-differentiated papillary serous carcinoma arising in serous adenofibroma of borderline malignancy. (15628924)
2005
13
Adenofibroma of the testis discovered at exploration for torsion after trauma. (14532817)
2003
14
Serous carcinoma arising in an adenofibroma of the endometrium. (12649677)
2003
15
Biliary adenofibroma: a rare neoplasm of bile duct origin with an indolent behavior. (12717255)
2003
16
Hepatic biliary adenofibroma: a hitherto unrecognized tumor in equines. Report of a case. (12627723)
2003
17
Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited]. (12968312)
2003
18
Uterine cervical adenofibroma associated with Turner's syndrome in a young woman. (12410376)
2002
19
Adenofibroma of the endometrium after tamoxifen therapy for breast cancer: MR findings. (12173004)
2002
20
The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center. (11257617)
2001
21
Nephrogenic adenofibroma in a young child. (11156329)
2000
22
Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma. (10645058)
2000
23
Papillary adenofibroma of cervix. (10638132)
1999
24
Uterine adenofibroma and adenosarcoma: CT and MR findings. (9530402)
1998
25
Nephrogenic adenofibroma: an unusual renal tumor. (9112535)
1997
26
Uterine adenofibroma presenting as a cystic adnexal mass. (7611824)
1995
27
Mucinous adenofibroma of the ovary: case report of the endocrinologic findings. (8063250)
1994
28
Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. (8314238)
1993
29
Uterine adenofibroma mimicking endometrial carcinoma: MR findings. (1727352)
1992
30
Nephrogenic adenofibroma. A novel kidney tumor of young people. (1373578)
1992
31
Papillary adenofibroma of the uterus. Report of a case involved by adenocarcinoma and review of the literature. (1595599)
1992
32
Adenofibroma of the uterus: multiple recurrences following wide local excision. (2351327)
1990
33
Complete remission of autoimmune thrombocytopenia after extirpation of a benign adenofibroma of the ovary. (2310694)
1990
34
Ovarian clear cell adenofibroma of borderline malignancy. A case report. (2793520)
1989
35
Adenofibroma of the rete testis. A case report with electron microscopy findings. (3364196)
1988
36
Malignant endometrioid adenofibroma of the ovary with serous cystadenoma. (3728014)
1986
37
MA1llerian adenofibroma. Case report. (3986174)
1985
38
Benign mixed MA1llerian tumour--adenofibroma of the fallopian tube. (6292075)
1982
39
Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. (6263458)
1981
40
Cystadenofibroma, adenofibroma, and malignant adenofibroma of the ovary. (917592)
1977
41
Papillary adenofibroma of the uterus: a benign mesodermal mixed tumor of MA1llerian orgin. (4364374)
1973
42
Intramural adenofibroma of the fallopian tube. Light and electron microscopy. (4709958)
1973
43
Papillary adenofibroma of the uterine cervix. (5558981)
1971
44
Serous adenofibroma and cystadenofibroma of the ovary. (5506473)
1970
45
Adenofibroma and cystadenofibroma of the ovary. (5242145)
1967
46
Serous adenofibroma and cystadenofibroma of the ovary: report of five cases with malignant changes in one. (14439461)
1959
47
Adenofibroma of urinary bladder: a case report. (13131417)
1953
48
A case of serous adenofibroma of the ovary. (20251666)
1947
49
The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats. (12279175)
1940
50
Tumour of the Ovary. ? Adenofibroma or Endothelioma. (19973838)
1909

Genetic Variations for Adenofibroma

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Expression for genes affiliated with Adenofibroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenofibroma

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Pathways for genes affiliated with Adenofibroma

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37NCBI BioSystems Database
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Pathways related to Adenofibroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PGR, INHA

Compounds for genes affiliated with Adenofibroma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Adenofibroma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1estrogen4410.1CALB2
2taxane449.6PTEN, PGR
3gnrh449.4INHA, PGR, MME
4crcs449.3PTEN, MME
5ribonucleic acid449.2INHA, PGR, MME
6b 723449.0MUC16, CALB2
7cyclophosphamide44 49 1110.9PTEN, PGR, MUC16
8hyaluronic acid44 249.7PTEN, MUC16, CALB2
9estradiol44 11 2410.5MUC16, INHA, PGR, PTEN
10doxorubicin44 49 1110.5PTEN, MME, PGR, MUC16
11hematoxylin448.5CALB2, MUC16, INHA, PTEN
12vegf448.3PTEN, MME, PGR, MUC16
13paclitaxel44 49 1110.3CALB2, MUC16, PGR, PTEN
14paraffin447.6PTEN, MME, PGR, INHA, MUC16, CALB2
15progesterone44 59 28 11 2411.6CALB2, MUC16, INHA, PGR, MME, PTEN
16testosterone44 59 11 2410.6CALB2, MUC16, INHA, PGR, MME, PTEN
17steroid447.6CALB2, MUC16, INHA, PGR, MME, PTEN

GO Terms for genes affiliated with Adenofibroma

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16Gene Ontology
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Molecular functions related to Adenofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.7PTEN, PAK4, MME, PGR, INHA, MUC16

Products for genes affiliated with Adenofibroma

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Sources for Adenofibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet