MCID: ADN017
MIFTS: 37

Adenofibroma malady

Summaries for Adenofibroma

Sources:
8Disease Ontology, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A cell type benign neoplasm that is composed of glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards: Adenofibroma, also known as adenofibroma, no icd-o subtype, is related to adenocarcinoma and wilms tumor. An important gene associated with Adenofibroma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways is Ovarian Infertility Genes. The compounds estrogen and taxane have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and lung, and related mouse phenotypes are normal and integument.

Aliases & Classifications for Adenofibroma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

adenofibroma 8 10 45 61
adenofibroma, no icd-o subtype 8


External Ids:

Disease Ontology8 DOID:2683
NCIt40 C8984
SNOMED-CT57 189823009, 2962009
MeSH35 D000232

Related Diseases for Adenofibroma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Adenofibroma family:

malignant adenofibroma

Diseases related to Adenofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.4PTEN, MME, PGR, INHA, MUC16, CALB2
2wilms tumor30.2MME, INHA, CALB2
3adenosarcoma30.2MME, PGR
4uterine sarcoma29.9MME
5cystadenoma29.9MME, INHA
6endometrial stromal sarcoma29.8MME, PGR, INHA
7papillary carcinoma29.8CALB2, MUC16, PGR
8clear cell adenofibroma10.5
9papillary adenofibroma10.5
10nephrogenic adenofibroma10.4
11uterine corpus adenofibroma10.3
12mucinous adenofibroma10.2
13clear cell adenocarcinoma10.2
14cervical adenofibroma10.2
15ovarian endometriosis10.2
16ovarian clear cell malignant adenofibroma10.2
17ovarian mucinous malignant adenofibroma10.1
18ovarian endometrioid malignant adenofibroma10.1
19giant adenofibroma of the breast10.1
20chordoma10.0INHA
21sarcoma10.0CALB2
22angiosarcoma10.0CALB2
23cystadenocarcinoma10.0MUC16
24plasma cell leukemia10.0MAF
25malignant peritoneal mesothelioma10.0CALB2
26meigs syndrome10.0MUC16
27liposarcoma10.0CALB2
28obesity10.0INHA
29ovarian serous cystadenocarcinoma10.0MUC16
30asthma10.0MME
31peritonitis10.0MUC16
32congestive heart failure10.0MME
33dysgerminoma10.0INHA
34proteus syndrome10.0PTEN
35leydig cell tumor10.0INHA, CALB2
36adenoma10.0CALB2, INHA
37rhabdomyosarcoma10.0INHA, CALB2
38granular cell tumor10.0CALB2, INHA
39sex cord-gonadal stromal tumor10.0CALB2, INHA
40lung cancer10.0PTEN
41pheochromocytoma10.0INHA, CALB2
42multiple myeloma10.0MAF
43choriocarcinoma10.0INHA, MME
44endodermal sinus tumor10.0MUC16, INHA
45seminoma10.0INHA, CALB2
46ductal carcinoma in situ10.0PGR
47epithelioid sarcoma10.0CALB2, MUC16
48malignant pleural mesothelioma10.0MUC16, CALB2
49malignant mesothelioma10.0CALB2, MUC16
50bilateral breast cancer10.0PGR

Graphical network of the top 20 diseases related to Adenofibroma:



Diseases related to adenofibroma

Clinical Features for Adenofibroma

Drugs & Therapeutics for Adenofibroma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adenofibroma

Drug clinical trials:

Search ClinicalTrials for Adenofibroma

Search NIH Clinical Center for Adenofibroma

Search CenterWatch for Adenofibroma

Genetic Tests for Adenofibroma

Anatomical Context for Adenofibroma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Adenofibroma:

33
Kidney, Liver, Lung, Thyroid, Breast, Ovary, Uterus, Testis, Cervix, Uterus corpus

Animal Models for Adenofibroma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Adenofibroma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1ARID1A, INHA, PGR, PTEN, CALB2
2MP:00107718.0PTEN, PAK4, MME, PGR, MAF

Publications for Adenofibroma

Sources:
51PubMed
See all sources

Articles related to Adenofibroma:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI. (24172789)
2013
2
Pulmonary adenofibroma: cytologic and clinicopathologic features of a rare benign primary lung lesion. (22645035)
2013
3
Pulmonary adenofibroma in a middle-aged man: report of a case. (23139047)
2013
4
Adenofibroma of the uterine cervix coexistent with endometriosis. (22795111)
2012
5
Unusual presentation of rare case of papillary adenofibroma of cervix in a young woman. (22606457)
2012
6
Serous adenofibroma of the testicle: case report and review of the literature. (20040787)
2010
7
Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. (20890073)
2010
8
Biliary adenofibroma of the liver: report of a case and review of the literature. (21151526)
2010
9
Adenofibroma and ectopic pregnancy of left fallopian tube: a rare coexistence. (20598059)
2010
10
Adenofibroma of Skene's Duct: A Case Report. (21152177)
2010
11
Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)
2009
12
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. (19655165)
2009
13
Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma. (18580316)
2008
14
Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clear-cell carcinogenic pathway. (18600856)
2008
15
Endometrial adenofibroma: a rare entity. (16858575)
2007
16
Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)
2006
17
Papillary adenofibroma of the cervix: a case report. (16041681)
2005
18
Fine-needle aspiration cytology of endometrioid adenofibroma of the ovary. (15236263)
2004
19
Adenofibroma of the testis discovered at exploration for torsion after trauma. (14532817)
2003
20
Paratesticular adenofibroma. (12745730)
2003
21
Hepatic biliary adenofibroma: a hitherto unrecognized tumor in equines. Report of a case. (12627723)
2003
22
Uterine cervical adenofibroma associated with Turner's syndrome in a young woman. (12410376)
2002
23
Biliary adenofibroma with malignant transformation and pulmonary metastases: CT findings. (12076957)
2002
24
The association of benign and malignant ovarian adenofibromas with breast cancer and thyroid disorders. (11927967)
2002
25
Nephrogenic adenofibroma in a young child. (11156329)
2000
26
Metanephric adenofibroma: report of a case and review of the literature. (10366157)
1999
27
Papillary adenofibroma of cervix. (10638132)
1999
28
Ovarian endometrioid adenocarcinoma coexistent with benign and borderline endometrioid adenofibroma: a case report. (9631607)
1998
29
A pregnant woman with clear cell adenocarcinoma of the ovary arising from endometriosis and with benign and borderline adenofibroma of the clear cell and endometrioid types. (9076421)
1997
30
Monosomy 22 in a case of biliary adenofibroma. (9078308)
1997
31
Sonographic characteristics of adenofibroma of the endometrium following tamoxifen therapy for breast cancer: two case reports. (8774105)
1996
32
Biliary adenofibroma. A heretofore unrecognized benign biliary tumor of the liver. (8422113)
1993
33
Uterine adenofibroma mimicking endometrial carcinoma: MR findings. (1727352)
1992
34
Papillary adenofibroma of the uterus. Report of a case involved by adenocarcinoma and review of the literature. (1595599)
1992
35
Adenofibroma of uterus and endocervix. (2013462)
1991
36
MA1llerian adenofibroma of the uterus with invasion of myometrium and pelvic veins. (2246094)
1990
37
Invasive ovarian endometrioid adenofibroma with omental implants and collision with endometrial adenocarcinoma. (3347431)
1988
38
Papillary adenofibroma of the cervix. An unusual tumour of the cervix. (3505509)
1987
39
Papillary adenofibroma of the endometrium: case report and review of the literature. (6489832)
1984
40
MA1llerian adenofibroma of the endometrium. A report of a case with ultrastructural study. (7117114)
1982
41
Bilateral papillary adenofibroma of the fallopian tube. (7468528)
1981
42
Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. (6263458)
1981
43
Cystadenofibroma, adenofibroma, and malignant adenofibroma of the ovary. (917592)
1977
44
Serous adenofibroma and cystadenofibroma of the ovary. (5506473)
1970
45
Adenofibroma and cystadenofibroma of the ovary. (5242145)
1967
46
Varied anatomical types of ovarian adenofibroma. A proposed classification. (6034964)
1967
47
Adenofibroma of ovary with partial differentiation to endometriosis. (18125052)
1949
48
A case of serous adenofibroma of the ovary. (20251666)
1947
49
The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats. (12279175)
1940
50
Tumour of the Ovary.A ? Adenofibroma or Endothelioma. (20898235)
1909

Genetic Variations for Adenofibroma

Expression for genes affiliated with Adenofibroma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adenofibroma

Search GEO for disease gene expression data for Adenofibroma.

Pathways for genes affiliated with Adenofibroma

Sources:
38NCBI BioSystems Database
See all sources

Pathways related to Adenofibroma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PGR, INHA

Compounds for genes affiliated with Adenofibroma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Adenofibroma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1estrogen4510.1CALB2
2taxane459.6PTEN, PGR
3gnrh459.4INHA, PGR, MME
4crcs459.3PTEN, MME
5ribonucleic acid459.2INHA, PGR, MME
6b 723459.0MUC16, CALB2
7cyclophosphamide45 50 1110.9PTEN, PGR, MUC16
8hyaluronic acid45 249.7PTEN, MUC16, CALB2
9estradiol45 11 2410.5MUC16, INHA, PGR, PTEN
10doxorubicin45 50 1110.5PTEN, MME, PGR, MUC16
11hematoxylin458.5CALB2, MUC16, INHA, PTEN
12vegf458.3PTEN, MME, PGR, MUC16
13paclitaxel45 50 1110.3CALB2, MUC16, PGR, PTEN
14paraffin457.6PTEN, MME, PGR, INHA, MUC16, CALB2
15progesterone45 60 29 11 2411.6CALB2, MUC16, INHA, PGR, MME, PTEN
16testosterone45 60 11 2410.6CALB2, MUC16, INHA, PGR, MME, PTEN
17steroid457.6CALB2, MUC16, INHA, PGR, MME, PTEN

GO Terms for genes affiliated with Adenofibroma

Sources:
16Gene Ontology
See all sources

Molecular functions related to Adenofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.7PTEN, PAK4, MME, PGR, INHA, MUC16

Products for genes affiliated with Adenofibroma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenofibroma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet