Adenofibroma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Adenofibroma

Sources:
⁸Disease Ontology, ³²MalaCards
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Disease Ontology:⁸ A cell type benign neoplasm that is composed of glandular and fibrous tissues, with a relatively large proportion of glands.

MalaCards: Adenofibroma, also known as adenofibroma, no icd-o subtype, is related to adenocarcinoma and endometriosis. An important gene associated with Adenofibroma is SHFM1 (split hand/foot malformation (ectrodactyly) type 1), and among its related pathways is Ovarian Infertility Genes. The compounds estrogen and taxane have been mentioned in the context of this disorder. Affiliated tissues include ovary, cervix and uterus, and related mouse phenotypes are normal and integument.

Aliases & Classifications for Adenofibroma

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁵⁶SNOMED-CT, ³⁹NCIt, ³⁴MeSH
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Aliases & Descriptions:

adenofibroma ⁸ ¹⁰ ⁴⁴ ⁶⁰

adenofibroma, no icd-o subtype ⁸

External Ids:

Disease Ontology⁸ DOID:2683

NCIt³⁹ C8984

SNOMED-CT⁵⁶ 189823009, 2962009

MeSH³⁴ D000232

UMLS⁶⁰ C0001422

Related Diseases for Adenofibroma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases in the Adenofibroma family:

Malignant Adenofibroma

Diseases related to Adenofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 102)

id	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	30.4	INHA, MME, CALB2, MUC16, PTEN, PGR
2	endometriosis	30.3	ARID1A, PTEN, PGR, MUC16, CALB2
3	adenosarcoma	30.1	MME, PGR
4	breast cancer	30.1	PTEN, MME, PGR, MUC16, INHA
5	sarcoma	29.8	CALB2
6	cystadenoma	29.8	MME, INHA
7	endometrial stromal sarcoma	29.8	PGR, INHA, MME
8	papillary carcinoma	29.8	MUC16, PGR, CALB2
9	endometrial carcinoma	29.8	MUC16, MME, PGR, PTEN
10	ovarian cancer	29.8	PTEN, PGR, CALB2, MUC16, INHA
11	clear cell adenofibroma	10.5
12	papillary adenofibroma	10.5
13	malignant adenofibroma	10.4
14	ovarian clear cell adenofibroma	10.4
15	nephrogenic adenofibroma	10.3
16	fallopian tube adenofibroma	10.3
17	cystadenofibroma	10.3
18	uterine corpus adenofibroma	10.2
19	ovarian endometrioid adenofibroma	10.2
20	mucinous adenofibroma	10.2
21	clear cell adenocarcinoma	10.2
22	ovarian clear cell malignant adenofibroma	10.2
23	cervical adenofibroma	10.2
24	ovarian mucinous adenofibroma	10.2
25	ovarian endometriosis	10.1
26	endometriosis of ovary	10.1
27	ovarian serous adenofibroma	10.1
28	ovary adenocarcinoma	10.1
29	ovarian mucinous malignant adenofibroma	10.0
30	ovarian endometrioid malignant adenofibroma	10.0
31	endometrial adenocarcinoma	10.0
32	giant adenofibroma of the breast	10.0
33	chordoma	10.0	INHA
34	angiosarcoma	10.0	CALB2
35	cystadenocarcinoma	10.0	MUC16
36	plasma cell leukemia	10.0	MAF
37	malignant peritoneal mesothelioma	10.0	CALB2
38	meigs syndrome	10.0	MUC16
39	liposarcoma	10.0	CALB2
40	obesity	10.0	INHA
41	ovarian serous cystadenocarcinoma	10.0	MUC16
42	asthma	10.0	MME
43	peritonitis	10.0	MUC16
44	congestive heart failure	10.0	MME
45	dysgerminoma	10.0	INHA
46	proteus syndrome	10.0	PTEN
47	uterine sarcoma	10.0	MME
48	leydig cell tumor	10.0	CALB2, INHA
49	adenoma	10.0	INHA, CALB2
50	rhabdomyosarcoma	10.0	INHA, CALB2

Graphical network of the top 20 diseases related to Adenofibroma:

Clinical Features for Adenofibroma

Drugs & Therapeutics for Adenofibroma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adenofibroma

Drug clinical trials:

Search ClinicalTrials for Adenofibroma

Search NIH Clinical Center for Adenofibroma

Search CenterWatch for Adenofibroma

Genetic Tests for Adenofibroma

Anatomical Context for Adenofibroma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Adenofibroma:

³²

Ovary, Cervix, Uterus, Lung, Breast, Testis, Liver, Kidney, Thyroid

Animal Models for Adenofibroma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Adenofibroma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	8.1	ARID1A, INHA, PGR, PTEN, CALB2
2	integument phenotype	MP:0010771	8.0	PTEN, PAK4, MME, PGR, MAF

Publications for Adenofibroma

Sources:
⁵⁰PubMed
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Articles related to Adenofibroma:

(show top 50) (show all 94)

id	Title	Authors	Year
1	Metanephric adenofibroma. (23587517)	Turner Ii R.M.... Cannon G.M.	2013
2	Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. (23153077)	Chen R.... Zhang Y.	2013
3	A composite renal tumor: metanephric adenofibroma, Wilms tumor, and renal cell carcinoma: a missing link? (21711207)	Galluzzo M.L.... VujaniA8 G.M.	2012
4	Clear cell adenocarcinoma arising in endometrial adenofibroma. (21355961)	Mikami S.... Mukai M.	2011
5	Serous adenofibroma of the testicle: case report and review of the literature. (20040787)	Subhawong T.K.... Hamper U.M.	2010
6	Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)	Gallardo A.... Prat J.	2009
7	An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. (19655165)	Yamamoto S.... Matsubara O.	2009
8	Adenofibroma of the fimbria: a common entity that is indistinguishable from ovarian adenofibroma. (18580316)	Bossuyt V.... Nucci M.R.	2008
9	Benign clear cell adenofibroma of the ovary. A case report with literature review. (17202822)	PaA9aoA9lu O.... Acikalin M.F.	2007
10	Uterine adenofibroma and endometrial stromal sarcoma associated with tamoxifen therapy: MR findings. (16890405)	Hayasaka K.... Tanaka Y.	2006
11	Adenofibroma of the endometrium protruding into the vaginal cavity: findings on transvaginal ultrasonography, MRI and CT. (17100829)	Konishi Y.... Tanaka T.	2006
12	Pathologic quiz case: a 54-year-old woman with bilateral pelvic masses. Well-differentiated papillary serous carcinoma arising in serous adenofibroma of borderline malignancy. (15628924)	Carter A.... Lawrence W.D.	2005
13	Adenofibroma of the testis discovered at exploration for torsion after trauma. (14532817)	Rogers C.G.... Pavlovich C.P.	2003
14	Serous carcinoma arising in an adenofibroma of the endometrium. (12649677)	Venkatraman L.... McCluggage W.G.	2003
15	Biliary adenofibroma: a rare neoplasm of bile duct origin with an indolent behavior. (12717255)	Varnholt H.... Lauwers G.Y.	2003
16	Hepatic biliary adenofibroma: a hitherto unrecognized tumor in equines. Report of a case. (12627723)	Salvaggio A.... Magro G.	2003
17	Solitary fibrous pseudopapillary tumor of the lung: pulmonary fibroadenoma and adenofibroma revisited]. (12968312)	Cavazza A.... Piana S.	2003
18	Uterine cervical adenofibroma associated with Turner's syndrome in a young woman. (12410376)	Ishiko O.... Ogita S.	2002
19	Adenofibroma of the endometrium after tamoxifen therapy for breast cancer: MR findings. (12173004)	Oshima H.... Hara M.	2002
20	The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center. (11257617)	Arroyo M.R.... Argani P.	2001
21	Nephrogenic adenofibroma in a young child. (11156329)	Guzman E.... Michiels J.F.	2000
22	Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma. (10645058)	Chan Y.J.... Ling F.	2000
23	Papillary adenofibroma of cervix. (10638132)	Mohan H.... Mohan P.	1999
24	Uterine adenofibroma and adenosarcoma: CT and MR findings. (9530402)	Lee H.K.... Yeon K.M.	1998
25	Nephrogenic adenofibroma: an unusual renal tumor. (9112535)	Bigg S.W.... Bari W.A.	1997
26	Uterine adenofibroma presenting as a cystic adnexal mass. (7611824)	Gemer O.... Segal S.	1995
27	Mucinous adenofibroma of the ovary: case report of the endocrinologic findings. (8063250)	Tohya T.... Okamura H.	1994
28	Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. (8314238)	Suster S.... Moran C.A.	1993
29	Uterine adenofibroma mimicking endometrial carcinoma: MR findings. (1727352)	Kaji Y.... Okizuka H.	1992
30	Nephrogenic adenofibroma. A novel kidney tumor of young people. (1373578)	Hennigar R.A.... Beckwith J.B.	1992
31	Papillary adenofibroma of the uterus. Report of a case involved by adenocarcinoma and review of the literature. (1595599)	Miller K.N.... McClure S.P.	1992
32	Adenofibroma of the uterus: multiple recurrences following wide local excision. (2351327)	Seltzer V.L.... Coffey E.L.	1990
33	Complete remission of autoimmune thrombocytopenia after extirpation of a benign adenofibroma of the ovary. (2310694)	von dem Borne A.E.... van der Tweel J.G.	1990
34	Ovarian clear cell adenofibroma of borderline malignancy. A case report. (2793520)	Katsube Y.... Fujiwara A.	1989
35	Adenofibroma of the rete testis. A case report with electron microscopy findings. (3364196)	Murao T.... Tanahashi T.	1988
36	Malignant endometrioid adenofibroma of the ovary with serous cystadenoma. (3728014)	Iwasaki I.... Takahashi A.	1986
37	MA1llerian adenofibroma. Case report. (3986174)	Anderson M.C.	1985
38	Benign mixed MA1llerian tumour--adenofibroma of the fallopian tube. (6292075)	de la Fuente A.A.	1982
39	Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. (6263458)	Zaloudek C.J.... Norris H.J.	1981
40	Cystadenofibroma, adenofibroma, and malignant adenofibroma of the ovary. (917592)	Czernobilsky B.	1977
41	Papillary adenofibroma of the uterus: a benign mesodermal mixed tumor of MA1llerian orgin. (4364374)	Vellios F.... Reagen J.W.	1973
42	Intramural adenofibroma of the fallopian tube. Light and electron microscopy. (4709958)	Kanbour A.I.... Salazar H.	1973
43	Papillary adenofibroma of the uterine cervix. (5558981)	Abell M.R.	1971
44	Serous adenofibroma and cystadenofibroma of the ovary. (5506473)	Compton H.L.... Finck F.M.	1970
45	Adenofibroma and cystadenofibroma of the ovary. (5242145)	Timonen S.... Purola E.	1967
46	Serous adenofibroma and cystadenofibroma of the ovary: report of five cases with malignant changes in one. (14439461)	Rothman D.... BLUMENTHAL H.T.	1959
47	Adenofibroma of urinary bladder: a case report. (13131417)	Levi M.... SOLOMON C.	1953
48	A case of serous adenofibroma of the ovary. (20251666)	SHARMAN A.... Sutherland A.M.	1947
49	The effect of the sex hormones on the growth of transplanted mammary adenofibroma in rats. (12279175)	Mohs F.E.	1940
50	Tumour of the Ovary. ? Adenofibroma or Endothelioma. (19973838)	Smith G.F.	1909

Genes related to Adenofibroma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Adenofibroma:

id	Symbol	Description	Score	Implication
1	SHFM1	split hand/foot malformation (ectrodactyly) type 1	21.04	GeneCards inferred : Disorders (show sections)
2	MAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	19.01	GeneCards inferred : Disorders (show sections)
3	INHA	inhibin, alpha	17.01	GeneCards inferred : Disorders (show sections)
4	MME	membrane metallo-endopeptidase	14.96	GeneCards inferred : Publications, Disorders (show sections)
5	ARID1A	AT rich interactive domain 1A (SWI-like)	12.96	GeneCards inferred : Disorders (show sections)
6	PGR	progesterone receptor	10.96	GeneCards inferred : Publications, Disorders (show sections)
7	PTEN	phosphatase and tensin homolog	8.96	GeneCards inferred : Publications, Disorders (show sections)
8	CALB2	calbindin 2	7.01	GeneCards inferred : Disorders (show sections)
9	MUC16	mucin 16, cell surface associated	5.01	GeneCards inferred : Publications, Disorders (show sections)
10	PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	2.96	GeneCards inferred : Disorders (show sections)

Products for genes related to Adenofibroma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	10	10	10
2	LSBio	-	-	10

Genetic Variations for Adenofibroma

Expression for genes affiliated with Adenofibroma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenofibroma

Search GEO for disease gene expression data for Adenofibroma.

Pathways for genes affiliated with Adenofibroma

Sources:
³⁷NCBI BioSystems Database
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Pathways related to Adenofibroma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Ovarian Infertility Genes³⁷	9.7	PGR, INHA

Compounds for genes affiliated with Adenofibroma

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ¹¹DrugBank, ²⁴HMDB, ⁵⁹Tocris Bioscience, ²⁸IUPHAR
See all sources

Compounds related to Adenofibroma according to GeneCards/GeneDecks:

(show all 17)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.1	CALB2
2	taxane⁴⁴	9.6	PTEN, PGR
3	gnrh⁴⁴	9.4	INHA, PGR, MME
4	crcs⁴⁴	9.3	PTEN, MME
5	ribonucleic acid⁴⁴	9.2	INHA, PGR, MME
6	b 723⁴⁴	9.0	MUC16, CALB2
7	cyclophosphamide⁴⁴ ⁴⁹ ¹¹	10.9	PTEN, PGR, MUC16
8	hyaluronic acid⁴⁴ ²⁴	9.7	PTEN, MUC16, CALB2
9	estradiol⁴⁴ ¹¹ ²⁴	10.5	MUC16, INHA, PGR, PTEN
10	doxorubicin⁴⁴ ⁴⁹ ¹¹	10.5	PTEN, MME, PGR, MUC16
11	hematoxylin⁴⁴	8.5	CALB2, MUC16, INHA, PTEN
12	vegf⁴⁴	8.3	PTEN, MME, PGR, MUC16
13	paclitaxel⁴⁴ ⁴⁹ ¹¹	10.3	CALB2, MUC16, PGR, PTEN
14	paraffin⁴⁴	7.6	PTEN, MME, PGR, INHA, MUC16, CALB2
15	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	11.6	CALB2, MUC16, INHA, PGR, MME, PTEN
16	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	10.6	CALB2, MUC16, INHA, PGR, MME, PTEN
17	steroid⁴⁴	7.6	CALB2, MUC16, INHA, PGR, MME, PTEN