MCID: ADN064
MIFTS: 39

Adenohypophysitis malady

Endocrine diseases, Rare diseases categories
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Summaries for Adenohypophysitis

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MalaCards: Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to adenoma and pituitary adenoma. An important gene associated with Adenohypophysitis is POMC (proopiomelanocortin), and among its related pathways are Development Leptin signaling via JAK STAT and MAPK cascades and Peptide hormone metabolism. The compounds flesinoxan and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and placenta, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Adenohypophysitis

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49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

adenohypophysitis 49
anterior pituitary hypophysitis 49


External Ids:

ICD10 via Orphanet26 E23.6

Related Diseases for Adenohypophysitis

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17GeneCards, 18GeneDecks
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Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4POMC, PRL, GH1, TRH
2pituitary adenoma30.4POMC, PRL, GH1, TRH
3thyroiditis30.2TRH, POMC
4hypopituitarism30.1TRH, GH1, PRL, POMC
5pituitary tumors30.1TRH, GH1, PRL, POMC
6pituitary apoplexy30.0TRH, PRL, POMC
7precocious puberty29.9GH1, PRL, POMC
8hypothyroidism29.8TRH, GH1, PRL, POMC
9choristoma10.1
10exophthalmos10.1TRH
11hyperthyroxinemia10.1TRH
12euthyroid sick syndrome10.1TRH
13melancholia10.0POMC, TRH
14endogenous depression10.0POMC, TRH
15sheehan syndrome10.0POMC, PRL
16neurogenic diabetes insipidus10.0POMC, PRL
17nelson syndrome10.0POMC, PRL
18klinefelter's syndrome10.0TRH, PRL
19pituitary carcinoma10.0POMC, PRL
20panic disorder10.0POMC, TRH
21chromophobe adenoma10.0GH1, PRL
22primary hyperoxaluria10.0TRH, POMC
23mccune albright syndrome10.0PRL, GH1
24pituitary gland disease10.0PRL, GH1
25acromegaly10.0PRL, GH1
26mood disorder10.0TRH, POMC
27hypothalamic disease10.0PRL, GH1
28empty sella syndrome10.0PRL, GH1
29gigantism10.0PRL, GH1
30hypersensitivity reaction type ii disease10.0POMC, TRH
31polycystic ovary syndrome10.0GH1, PRL
32gonadal disease10.0GH1, POMC
33neuronitis10.0
34infertility10.0
35lymphocytic hypophysitis10.0
36rheumatic disease10.0
37cushing's syndrome10.0POMC, GH1
38hypoadrenalism10.0POMC, GH1
39short stature10.0GH1, PRL
40neuroendocrine tumor10.0POMC, GH1
41diabetes insipidus10.0POMC, PRL, TRH
42amenorrhea10.0POMC, PRL, TRH
43cholera10.0TRH, POMC
44type 1 diabetes mellitus10.0TRH, GH1
45carcinoid syndrome10.0GH1, POMC
46hyperglycemia10.0GH1, POMC
47hyperthyroidism10.0PRL, GH1, TRH
48acth deficiency10.0GH1, PRL, POMC
49acth-secreting pituitary adenoma10.0POMC, PRL, GH1
50thyrotropin deficiency, isolated10.0GH1, PRL, POMC

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to adenohypophysitis

Symptoms for Adenohypophysitis

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Drugs & Therapeutics for Adenohypophysitis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Adenohypophysitis

Search NIH Clinical Center for Adenohypophysitis

Genetic Tests for Adenohypophysitis

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Anatomical Context for Adenohypophysitis

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33MalaCards
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MalaCards organs/tissues related to Adenohypophysitis:

33
Pituitary, Thyroid, Placenta

Animal Models for Adenohypophysitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Adenohypophysitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5GH1, PRL, POMC
2MP:00053798.0TRH, GH1, PRL, POMC
3MP:00036317.9POMC, PRL, GH1, TRH
4MP:00053767.7TRH, GH1, PRL, POMC

Publications for Adenohypophysitis

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52PubMed
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Articles related to Adenohypophysitis:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog. (23204587)
2012
2
Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. (20807820)
2010
3
Adenohypophysitis in rat pituitary allografts. (20586813)
2010
4
Relationship of plasma ghrelin and adenohypophyseal hormone levels in female precocious puberty]. (18925720)
2008
5
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: cytoplasmic clusterin localization in adenohypophysis is related to aging. (18239862)
2008
6
Granulomatous adenohypophysitis after interferon and ribavirin therapy. (17490932)
2007
7
Longitudinal study of patients with idiopathic isolated TSH deficiency: possible progression of pituitary dysfunction in lymphocytic adenohypophysitis. (16896268)
2006
8
Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line. (15326563)
2004
9
Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells. (11999717)
2002
10
Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study. (11515793)
2001
11
The regulation of adenohypophyseal prolactin secretion: effect of triiodothyronine and methylene blue on estrogenized rat adenohypophysis. (10984069)
2000
12
Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma. (10926106)
2000
13
Spontaneous recovery from pathologically confirmed lymphocytic adenohypophysitis with a dramatic reduction of hypophyseal size. (10563747)
1999
14
Lymphocytic adenohypophysitis: skull radiographs and MRI. (9541922)
1998
15
Comparative immunohistochemical study of stellate cells in normal canine and equine adenohypophyses and in pituitary tumours. (9500236)
1998
16
Lymphocytic adenohypophysitis and neurohypophysitis. (9187559)
1997
17
Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. (9152609)
1997
18
Effects of intravenously infused pituitary adenylate cyclase-activating polypeptide on adenohypophyseal Hormone secretion in normal men. (8875442)
1996
19
Long-term clinical course of two cases of lymphocytic adenohypophysitis. (8930533)
1996
20
Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. (7758238)
1995
21
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. (7623353)
1995
22
Lymphocytic Adenohypophysitis Associated with Rathke's Cleft Cyst. (12114815)
1995
23
Immunohistochemical demonstration of adenohypophyseal hormones during postnatal ontogenesis in the Gray Short-tailed Opossum, Monodelphis domestica (marsupialia). (8835137)
1995
24
Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells. (7969791)
1994
25
Membrane receptors and coupling proteins in adenohypophyseal cells]. (8242419)
1993
26
Adenohypophyseal and sex hormones in pediatric rheumatic diseases. (8496873)
1993
27
Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. (1545900)
1992
28
Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy. Proposal for medical treatment. (2048602)
1991
29
Lymphocytic adenohypophysitis: an immunohistochemical study. (1891758)
1991
30
Adenohypophysitis associated with sebaceous gland atrophy in a dog. (1949513)
1991
31
A case of pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis]. (2070891)
1991
32
Lymphocytic adenohypophysitis presenting as infertility. Case report. (2013781)
1991
33
Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women. (2308340)
1990
34
Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. (2172282)
1990
35
Lymphocytic adenohypophysitis: report of two cases. (2700055)
1989
36
Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. (3380286)
1988
37
A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. (3215147)
1988
38
Lymphocytic adenohypophysitis. (3278777)
1988
39
Lymphocytic adenohypophysitis in a man. (3208233)
1988
40
Lymphocytic adenohypophysitis. Report of a case with demonstration of spontaneous tumour regression and a review of the literature. (3077051)
1988
41
Lymphocytic adenohypophysitis of pregnancy with complete recovery. (3601028)
1987
42
Lymphoid adenohypophysitis. (3739708)
1986
43
Lymphocytic adenohypophysitis. A review and a case. (4017662)
1985
44
Hypothalamic neuronal hamartoma and adenohypophyseal neuronal choristoma: their association with growth hormone adenoma of the pituitary gland. (6631456)
1983
45
Intrasellar neural-adenohypophyseal choristoma. A morphological and immunocytochemical study. (7042919)
1982
46
Lymphoid adenohypophysitis with radiologic and clinical findings resembling a pituitary tumor. (6810678)
1982
47
Galactorrhea associated with lymphocytic adenohypophysitis. Case report. (7195731)
1981
48
Lymphoid adenohypophysitis presenting as a pituitary tumor. (7424950)
1980
49
Allergic adrenalitis and adenohypophysitis: further observations on production and passive transfer. (5773150)
1969
50
Allergic adenohypophysitis: new experimental disease of the pituitary gland. (6057291)
1967

Variations for Adenohypophysitis

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Expression for genes affiliated with Adenohypophysitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for genes affiliated with Adenohypophysitis

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50PathCards, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Adenohypophysitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4POMC, TRH
2
Show member pathways
9.3GH1, POMC
39.1PRL, POMC
4
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.0PRL, GH1
5
Show member pathways
Type III interferon signaling38
9.0GH1, PRL
6
Show member pathways
9.0GH1, PRL
7
Show member pathways
9.0PRL, GH1
89.0GH1, PRL
9
Show member pathways
8.0TRH, GH1, PRL, POMC
10
Show member pathways
8.0TRH, GH1, PRL, POMC

Compounds for genes affiliated with Adenohypophysitis

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45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 3BitterDB, 61Tocris Bioscience, 24HMDB
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Compounds related to Adenohypophysitis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1flesinoxan459.5PRL, POMC
2acth 1-24459.4PRL, POMC
3ipsapirone45 2910.4PRL, POMC
411 deoxycortisol459.4PRL, POMC
5quinagolide459.4PRL, GH1
6betamethasone45 1110.3GH1, POMC
7domperidone45 29 1111.3TRH, PRL
85-hydroxytryptophan459.2GH1, PRL
9leuprolide acetate459.1PRL, GH1
10lanreotide45 2910.1PRL, GH1
11mirtazapine45 51 1111.0PRL, POMC
12clomiphene citrate459.0PRL, GH1
13fenfluramine45 29 1111.0TRH, PRL, POMC
14haloperidol45 51 29 3 1113.0POMC, TRH, PRL
15ghrp458.9TRH, GH1, PRL
16pyridostigmine45 119.9TRH, GH1, PRL
17hexarelin45 299.9POMC, PRL, GH1
18sulpiride45 29 1110.9GH1, TRH, PRL
19naltrexone45 29 51 1111.9POMC, GH1, PRL
20metoclopramide45 51 1110.9GH1, PRL, TRH
21apomorphine29 45 1110.9PRL, GH1, TRH
22cocaine45 119.9POMC, PRL, TRH
23dehydroepiandrosterone sulfate458.9PRL, GH1, POMC
24opiate458.9GH1, PRL, POMC
25dhea458.9POMC, GH1, PRL
26melatonin45 29 61 24 1112.9TRH, GH1, PRL
27androstenedione45 249.9POMC, PRL, GH1
28levodopa45 119.9PRL, TRH, GH1
29corticosterone45 61 2410.9PRL, POMC, GH1
30epinephrine45 24 1110.7POMC, PRL, GH1
31ribonucleic acid458.7POMC, PRL, GH1
32acetylcholine45 51 29 24 1112.5TRH, POMC, GH1
33bromocriptine45 29 1110.4POMC, TRH, GH1, PRL
34naloxone45 29 51 1111.4POMC, PRL, TRH, GH1
35clonidine45 51 29 1111.4POMC, PRL, GH1, TRH
36octreotide45 61 29 1111.4PRL, POMC, TRH, GH1
37triiodothyronine458.4POMC, GH1, TRH, PRL
38hydrocortisone45 3 61 1111.4GH1, TRH, PRL, POMC
39thyroxine45 249.4TRH, POMC, GH1, PRL
40acth458.4TRH, POMC, PRL, GH1
41gnrh458.4POMC, PRL, GH1, TRH
42norepinephrine45 24 1110.4TRH, GH1, PRL, POMC
43estradiol45 24 1110.4PRL, POMC, GH1, TRH
44dopamine45 29 24 1111.4GH1, TRH, PRL, POMC
45progesterone45 29 61 24 1112.4POMC, GH1, TRH, PRL
46testosterone45 61 24 1111.3POMC, GH1, TRH, PRL
47dexamethasone45 51 29 1111.3TRH, GH1, POMC, PRL
48arginine458.3TRH, GH1, PRL, POMC
49estrogen458.3PRL, GH1, POMC, TRH
50glucose458.3TRH, GH1, PRL, POMC

GO Terms for genes affiliated with Adenohypophysitis

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16Gene Ontology
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Cellular components related to Adenohypophysitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.4TRH, POMC
2extracellular regionGO:0055767.7TRH, GH1, PRL, POMC

Biological processes related to Adenohypophysitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:0072679.4TRH, POMC
2positive regulation of JAK-STAT cascadeGO:0464278.9GH1, PRL
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603978.7GH1, PRL

Molecular functions related to Adenohypophysitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051488.7GH1, PRL
2hormone activityGO:0051798.5GH1, PRL, POMC

Products for genes affiliated with Adenohypophysitis

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Sources for Adenohypophysitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet