MCID: ADN064
MIFTS: 40

Adenohypophysitis malady

Endocrine diseases category

Summaries for Adenohypophysitis

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MalaCards: Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to adenoma and pituitary adenoma. An important gene associated with Adenohypophysitis is GHRH (growth hormone releasing hormone), and among its related pathways are Glycoprotein hormones and Prolactin receptor signaling. The compounds estrogen and glutamate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Aliases & Classifications for Adenohypophysitis

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48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

adenohypophysitis 48
anterior pituitary hypophysitis 48


External Ids:

ICD10 via Orphanet26 E23.6

Related Diseases for Adenohypophysitis

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17GeneCards, 18GeneDecks
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Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4ADCYAP1, ENO2, POMC, TRH, SST, SYP
2pituitary adenoma30.4ADCYAP1, ADCY10, ADM, POMC, TRH, SST
3thyroiditis30.1POMC, TRH
4hypopituitarism30.1POMC, TRH, SST, PRL, GH1, GHRH
5pituitary gland disease29.9PRL, GH1
6infertility29.9CLU, PRL, GHRH, GNRH1
7pituitary apoplexy29.9POMC, TRH, PRL, GNRH1
8diabetes insipidus29.9OXT, POMC, TRH, PRL, GHRH
9hypothyroidism29.8ADCY10, OXT, POMC, TRH, PRL, GH1
10thyrotoxicosis10.0TRH
11pituitary hypoplasia10.0GHRH
12goiter10.0TRH
13phaeochromocytoma10.0ADM
14multiple endocrine neoplasia10.0VIP
15melanotic neuroectodermal tumor10.0SYP
16blindness10.0CLU
17essential hypertension10.0ADM
18teratoma10.0ENO2
19eating disorder10.0GHRL
20thymus cancer10.0SYP
21bulimia nervosa10.0GHRL
22cystadenoma10.0CLU
23ileus10.0GHRL
24pneumonia10.0ADM
25endometriosis10.0GNRH1
26cerebral primitive neuroectodermal tumor10.0ENO2
27osteoarthritis10.0CLU
28brain cancer10.0SYP
29endometrial carcinoma10.0GNRH1
30adrenal carcinoma10.0POMC
31scrapie10.0CLU
32systemic lupus erythematosus10.0PRL
33gangliocytoma10.0SYP
34addison's disease10.0POMC
35carney complex10.0POMC
36gastroparesis10.0GHRL
37hemangioma10.0CLU
38cocaine abuse10.0DRD2
39morbid obesity10.0GHRL
40myopathy10.0POMC
41restless legs syndrome10.0DRD2
42dyspepsia10.0GHRL
43subependymal giant cell astrocytoma10.0ENO2, SYP
44epulis10.0ENO2
45cerebrovascular disease10.0ADM, TRH
46pancreatitis10.0SST
47amyotrophic lateral sclerosis10.0SYP
48rhabdoid cancer10.0ENO2
49hepatitis10.0GHR
50diabetic retinopathy10.0ADM

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to adenohypophysitis

Clinical Features for Adenohypophysitis

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Drugs & Therapeutics for Adenohypophysitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenohypophysitis

Drug clinical trials:

Search ClinicalTrials for Adenohypophysitis

Search NIH Clinical Center for Adenohypophysitis

Search CenterWatch for Adenohypophysitis

Genetic Tests for Adenohypophysitis

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Anatomical Context for Adenohypophysitis

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32MalaCards
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MalaCards organs/tissues related to Adenohypophysitis:

32
Pituitary

Animal Models for Adenohypophysitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenohypophysitis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9DRD2, GHR, GHRH, OXT
2MP:00053758.9GHR, GH1, POMC, ADCYAP1, DRD2
3MP:00053708.2GHR, GHRH, GH1, PRL, POMC, ADM
4MP:00053677.5OXT, POMC, GHR, DRD2, GNRH1, CLU
5MP:00053787.2GHR, POMC, TRH, SST, GHRH, DRD2
6MP:00053877.1ADCYAP1, ADM, CLU, POMC, SST, PRL
7MP:00053857.1DRD2, GHR, POMC, OXT, CLU, ADM
8MP:00053896.9VIP, VIM, GNRH1, DRD2, GHR, ADCYAP1
9MP:00053866.2VIM, VIP, ADCYAP1, ADM, ENO2, OXT
10MP:00036315.3VIM, SST, TRH, POMC, OXT, CLU
11MP:00053765.1SST, ADCY10, ADM, CLU, OXT, VIP

Publications for Adenohypophysitis

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Genetic Variations for Adenohypophysitis

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Expression for genes affiliated with Adenohypophysitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for genes affiliated with Adenohypophysitis

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Adenohypophysitis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Adenohypophysitis according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4TRH
2glutamate449.3TRH, GHRH, GHRL, GNRH1, DRD2
3prostaglandin449.3VIP, VIM, GHRL, ADCY10, ADCYAP1
4cycloheximide449.3GHR, GHRH, TRH, ADCY10
5forskolin44 49 1111.2VIM, GHRH, POMC, ENO2, ADM
6pirenzepine44 28 1111.1DRD2, GHRL, GHRH, GH1, SST, ADCY10
7atropine44 28 1111.1ADCYAP1, ADCY10, TRH, GH1, GHRH, GHRL
8pyridostigmine44 1110.0GHRL, GHRH, GH1, PRL, SST, TRH
9propranolol44 28 49 11 2412.9VIP, GHRH, GH1, SST, ADM, ADCY10
10cabergoline28 44 1110.9GNRH1, DRD2, GHR, GH1, PRL, SST
11creatinine448.9GNRH1, GHR, GHRL, SYP, POMC
12melatonin44 59 28 11 2412.6GH1, PRL, TRH, OXT, ADCYAP1
13ghrp448.5GHR, GHRL, GHRH, GH1, PRL, SST
14dihydrotestosterone44 28 11 2411.4VIP, VIM, GNRH1, GHR, GH1, PRL
15triiodothyronine448.4GHR, GHRL, GHRH, GH1, PRL, TRH
16corticosterone44 59 2410.3VIP, GHRL, GH1, PRL, POMC, OXT
17isoproterenol44 119.3VIP, VIM, GNRH1, GH1, SST, ADM
18hydrocortisone44 2 59 1111.2VIM, GHRL, GH1, PRL, SST, TRH
19gnrh448.2VIP, GNRH1, GHR, GHRL, GHRH, GH1
20levodopa44 119.2GHR, GHRH, GH1, PRL, SST, TRH
21nifedipine44 49 28 1111.2VIP, GNRH1, GHRL, GHRH, GH1, SST
22apomorphine44 28 1110.2DRD2, GH1, PRL, TRH, OXT, ADCYAP1
23hexarelin44 289.0GHR, GHRL, GHRH, GH1, PRL, SST
24clonidine44 28 1110.0GHR, GHRH, GH1, PRL, SST, TRH
25ibmx44 28 5910.0VIP, GH1, SST, TRH, ENO2, ADM
26dbc-amp448.0VIP, VIM, GHRH, SYP, TRH, ENO2
27bromocriptine28 44 119.9ADCY10, POMC, VIP, GNRH1, GHR, GHRH
28opiate447.9GHRL, GHRH, GH1, PRL, POMC, OXT
29ribonucleic acid447.8GNRH1, GHR, GHRL, GHRH, GH1, PRL
30dexamethasone44 49 28 1110.4VIP, GNRH1, GHRL, GHRH, GH1, TRH
31acetylcholine44 49 28 11 2411.3DRD2, GHRL, GH1, SYP, SST, TRH
32steroid447.3GH1, GHRH, GHR, GNRH1, PRL, SYP
33estradiol44 11 249.2CLU, OXT, VIM, GNRH1, GHR, GHRH
345-hydroxytryptamine447.1VIP, VIM, GNRH1, DRD2, GHRL, PRL
35epinephrine44 11 249.1VIP, GNRH1, DRD2, GHRL, GH1, PRL
36lactate447.0VIP, VIM, GNRH1, GHRL, GH1, SST
37thyroxine44 248.0VIP, GNRH1, GHR, GHRL, GHRH, GH1
38norepinephrine44 11 249.0GNRH1, DRD2, GHRH, PRL, SYP, TRH
39paraffin447.0VIM, GHR, GHRL, GH1, SYP, POMC
40dopamine44 28 11 249.7TRH, OXT, CLU, ENO2, ADCYAP1, GHRH
41naloxone44 49 28 119.7PRL, SST, TRH, POMC, OXT, ADCY10
42octreotide44 59 28 119.5VIP, GNRH1, DRD2, GHR, GHRL, GHRH
43vegf446.4VIM, VIP, DRD2, GHRL, GH1, ADCYAP1
44aspartate446.4VIP, VIM, GNRH1, GHR, GHRH, GH1
45gaba446.4ADCYAP1, ENO2, VIP, VIM, GNRH1, DRD2
46adenylate446.4GHRH, GH1, SST, TRH, POMC, ENO2
47progesterone44 59 28 11 249.9VIM, GNRH1, GHR, GHRH, GH1, PRL
48arginine445.8ADCYAP1, VIP, VIM, GNRH1, GHR, GHRL
49acth445.7GHR, GHRL, GHRH, GH1, PRL, SYP
50testosterone44 59 11 248.1VIP, VIM, GNRH1, GHR, GHRL, GHRH

GO Terms for genes affiliated with Adenohypophysitis

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16Gene Ontology
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Cellular components related to Adenohypophysitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.9GHRL, POMC
2terminal boutonGO:0431959.2OXT, ADCYAP1, GHRH
3neuronal cell bodyGO:0430258.8ADCY10, SST, GHR, VIP
4secretory granuleGO:0301418.6PRL, TRH, POMC, OXT
5extracellular spaceGO:0056157.0GNRH1, GHR, GHRL, GHRH, GH1, SST
6extracellular regionGO:0055766.0ADCYAP1, VIP, GNRH1, GHR, GHRL, GHRH

Biological processes related to Adenohypophysitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.3VIP, ADCYAP1
2adenohypophysis developmentGO:02198410.3DRD2, GHRH
3growth hormone secretionGO:03025210.2GHRL, GHRH
4cAMP-mediated signalingGO:01993310.2GHRH, ADM, ADCYAP1
5ovulation cycleGO:04269810.2GNRH1, PRL
6positive regulation of vasodilationGO:04590910.1VIP, ADM, ADCYAP1
7negative regulation of potassium ion transportGO:04326710.1VIP, ADCYAP1
8growth hormone receptor signaling pathwayGO:06039610.0GHR, GH1
9positive regulation of JAK-STAT cascadeGO:04642710.0PRL, GH1
10response to foodGO:03209410.0GHRH, GHR
11cAMP biosynthetic processGO:0061719.9ADM, ADCY10
12positive regulation of growth hormone secretionGO:0601249.9ADCYAP1, GHRH, GHRL, DRD2
13G-protein coupled receptor internalizationGO:0020319.9DRD2, ADM
14JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.9GHR, GH1, PRL
15positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.8GH1, GHRH
16response to ethanolGO:0454719.6GNRH1, PRL, TRH, ADCYAP1
17hormone-mediated signaling pathwayGO:0097559.6TRH, GHRL, GHR
18positive regulation of multicellular organism growthGO:0400189.4DRD2, GHR, GHRL, GHRH, GH1
19elevation of cytosolic calcium ion concentrationGO:0072049.3GHRL, OXT, ADM, ADCYAP1
20response to glucocorticoid stimulusGO:0513849.2ADM, OXT, GHR
21response to estradiol stimulusGO:0323559.1OXT, PRL, GH1, GHR
22female pregnancyGO:0075659.1GNRH1, PRL, OXT, ADM, ADCYAP1
23cell-cell signalingGO:0072678.2ADCYAP1, GNRH1, GHRH, SST, TRHDE, TRH
24signal transductionGO:0071657.9GNRH1, TRHDE, TRH, POMC, OXT, ADM

Molecular functions related to Adenohypophysitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.0PRL, GH1
2growth hormone-releasing hormone activityGO:0166089.7GHRH, GHRL
3neuropeptide hormone activityGO:0051849.4VIP, TRH, ADCYAP1
4hormone activityGO:0051798.6ADM, POMC, SST, PRL, GH1, GNRH1

Products for genes affiliated with Adenohypophysitis

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Sources for Adenohypophysitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet