MCID: ADN064
MIFTS: 39

Adenohypophysitis

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Adenohypophysitis

Summaries for Adenohypophysitis

MalaCards based summary : Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to adenoma and pituitary apoplexy, and has symptoms including panhypopituitarism, amenorrhea and blurred vision. An important gene associated with Adenohypophysitis is PRL (Prolactin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Jak-STAT signaling pathway (KEGG). Affiliated tissues include pituitary, thyroid and placenta, and related phenotype is endocrine/exocrine gland.

Related Diseases for Adenohypophysitis

Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 adenoma 29.8 GH1 POMC PRL
2 pituitary apoplexy 29.8 POMC PRL
3 lymphocytic hypophysitis 29.7 GH1 POMC
4 pituitary tumors 29.5 GH1 POMC PRL
5 hypopituitarism 29.5 GH1 POMC PRL
6 diabetes insipidus 29.4 POMC PRL
7 pituitary adenoma 29.3 GH1 POMC PRL TRH
8 hypothyroidism, congenital, nongoitrous, 4 29.3 GH1 POMC PRL
9 pituitary gland disease 29.2 GH1 POMC PRL
10 generalized resistance to thyroid hormone 10.3 PRL TRH
11 fibrous dysplasia/mccune-albright syndrome 10.2 GH1 PRL
12 tsh producing pituitary tumor 10.2 GH1 PRL
13 pituitary adenoma 1, multiple types 10.2 GH1 PRL
14 gigantism 10.2 GH1 PRL
15 tetrahydrobiopterin deficiency 10.1 GH1 PRL
16 pituitary infarct 10.1 POMC PRL
17 chiasmal syndrome 10.1 POMC PRL
18 sella turcica neoplasm 10.1 POMC PRL
19 tuberculum sellae meningioma 10.1 POMC PRL
20 pituitary stalk interruption syndrome 10.1 GH1 PRL
21 nelson syndrome 10.1 POMC PRL
22 sheehan syndrome 10.1 POMC PRL
23 suprasellar meningioma 10.1 POMC TRH
24 mccune-albright syndrome 10.1 GH1 PRL
25 acth-secreting pituitary adenoma 10.1 POMC PRL
26 central nervous system organ benign neoplasm 10.1 POMC PRL
27 fibrous dysplasia 10.1 GH1 PRL
28 sex differentiation disease 10.1 POMC PRL
29 diabetes insipidus, neurohypophyseal 10.1 POMC PRL
30 adrenal cortex disease 10.1 POMC PRL
31 adrenal gland disease 10.0 POMC PRL
32 premenstrual tension 10.0 POMC PRL
33 craniopharyngioma 10.0 PRL TRH
34 hypoadrenalism 10.0 GH1 POMC
35 gynecomastia 10.0 POMC PRL
36 female reproductive system disease 10.0 POMC PRL
37 hyperandrogenism 9.9 POMC PRL
38 pilonidal sinus 9.9 CD4 IL2RA
39 pseudohypoparathyroidism, type ia 9.9 GH1 PRL TRH
40 thyroiditis 9.9
41 gonadal disease 9.9 GH1 POMC
42 hyperthyroidism 9.9 GH1 PRL TRH
43 chronic graft versus host disease 9.9 CD4 IL2RA
44 pituitary-dependent cushing's disease 9.8 POMC PRL TRH
45 endocrine organ benign neoplasm 9.8 POMC PRL TRH
46 thyroid gland disease 9.8 POMC PRL TRH
47 organ system benign neoplasm 9.8 POMC PRL TRH
48 cell type benign neoplasm 9.8 POMC PRL TRH
49 amenorrhea 9.8 POMC PRL TRH
50 hypothalamic disease 9.8 GH1 POMC PRL

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to Adenohypophysitis

Symptoms & Phenotypes for Adenohypophysitis

Human phenotypes related to Adenohypophysitis:

55 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 panhypopituitarism 55 31 hallmark (90%) Very frequent (99-80%) HP:0000871
2 amenorrhea 55 31 frequent (33%) Frequent (79-30%) HP:0000141
3 blurred vision 55 31 frequent (33%) Frequent (79-30%) HP:0000622
4 impotence 55 31 frequent (33%) Frequent (79-30%) HP:0000802
5 prolactin excess 55 31 frequent (33%) Frequent (79-30%) HP:0000870
6 pallor 55 31 frequent (33%) Frequent (79-30%) HP:0000980
7 orthostatic hypotension 55 31 frequent (33%) Frequent (79-30%) HP:0001278
8 normochromic anemia 55 31 frequent (33%) Frequent (79-30%) HP:0001895
9 nausea 55 31 frequent (33%) Frequent (79-30%) HP:0002018
10 headache 55 31 frequent (33%) Frequent (79-30%) HP:0002315
11 hyposthenuria 55 31 frequent (33%) Frequent (79-30%) HP:0003158
12 progressive visual field defects 55 31 frequent (33%) Frequent (79-30%) HP:0007987
13 decreased circulating cortisol level 55 31 frequent (33%) Frequent (79-30%) HP:0008163
14 gonadotropin deficiency 55 31 frequent (33%) Frequent (79-30%) HP:0008213
15 decreased serum estradiol 55 31 frequent (33%) Frequent (79-30%) HP:0008214
16 decreased testosterone in males 55 31 frequent (33%) Frequent (79-30%) HP:0008230
17 secondary growth hormone deficiency 55 31 frequent (33%) Frequent (79-30%) HP:0008240
18 pituitary hypothyroidism 55 31 frequent (33%) Frequent (79-30%) HP:0008245
19 adrenocorticotropin deficient adrenal insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0011735
20 adrenocorticotropic hormone deficiency 55 31 frequent (33%) Frequent (79-30%) HP:0011748
21 abnormal size of pituitary gland 55 31 frequent (33%) Frequent (79-30%) HP:0012504
22 abnormal thalamic mri signal intensity 55 31 frequent (33%) Frequent (79-30%) HP:0012696
23 decreased female libido 55 31 frequent (33%) Frequent (79-30%) HP:0030018
24 decreased male libido 55 31 frequent (33%) Frequent (79-30%) HP:0040306
25 sensorineural hearing impairment 55 31 occasional (7.5%) Occasional (29-5%) HP:0000407
26 diplopia 55 31 occasional (7.5%) Occasional (29-5%) HP:0000651
27 hashimoto thyroiditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000872
28 hyponatremia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002902
29 antinuclear antibody positivity 55 31 occasional (7.5%) Occasional (29-5%) HP:0003493
30 poor appetite 55 31 occasional (7.5%) Occasional (29-5%) HP:0004396
31 chronic lymphocytic meningitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0007041
32 prolactin deficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0008202

MGI Mouse Phenotypes related to Adenohypophysitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 CD4 IL2RA POMC PRL TRH

Drugs & Therapeutics for Adenohypophysitis

Search Clinical Trials , NIH Clinical Center for Adenohypophysitis

Genetic Tests for Adenohypophysitis

Anatomical Context for Adenohypophysitis

MalaCards organs/tissues related to Adenohypophysitis:

38
Pituitary, Thyroid, Placenta

Publications for Adenohypophysitis

Articles related to Adenohypophysitis:

(show top 50) (show all 65)
# Title Authors Year
1
Post-partum hypoglycemia and hypothermia as first manifestations of lymphocytic adenohypophysitis: A case report. ( 26786534 )
2016
2
Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog. ( 23204587 )
2012
3
Lymphocytic adenohypophysitis. ( 21592417 )
2011
4
Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. ( 20807820 )
2010
5
Adenohypophysitis in rat pituitary allografts. ( 20586813 )
2010
6
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: cytoplasmic clusterin localization in adenohypophysis is related to aging. ( 18239862 )
2008
7
Adrenomedullin expression in pituitary adenomas and nontumoral adenohypophyses. ( 17952853 )
2008
8
[Relationship of plasma ghrelin and adenohypophyseal hormone levels in female precocious puberty]. ( 18925720 )
2008
9
Granulomatous adenohypophysitis after interferon and ribavirin therapy. ( 17490932 )
2007
10
Longitudinal study of patients with idiopathic isolated TSH deficiency: possible progression of pituitary dysfunction in lymphocytic adenohypophysitis. ( 16896268 )
2006
11
Pituitary apoplexy as a consequence of lymphocytic adenohypophysitis in a pregnant woman: a case report. ( 15949237 )
2005
12
Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line. ( 15326563 )
2004
13
Therapy for lymphocytic adenohypophysitis. ( 12636229 )
2003
14
Lymphocytic adenohypophysitis simulating a pituitary adenoma in a pregnant woman. ( 12528294 )
2002
15
Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells. ( 11999717 )
2002
16
Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study. ( 11515793 )
2001
17
Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma. ( 10926106 )
2000
18
The regulation of adenohypophyseal prolactin secretion: effect of triiodothyronine and methylene blue on estrogenized rat adenohypophysis. ( 10984069 )
2000
19
Spontaneous recovery from pathologically confirmed lymphocytic adenohypophysitis with a dramatic reduction of hypophyseal size. ( 10563747 )
1999
20
Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: role of the cAMP pathway. ( 9576608 )
1998
21
Lymphocytic adenohypophysitis: skull radiographs and MRI. ( 9541922 )
1998
22
Comparative immunohistochemical study of stellate cells in normal canine and equine adenohypophyses and in pituitary tumours. ( 9500236 )
1998
23
Lymphocytic adenohypophysitis and neurohypophysitis. ( 9187559 )
1997
24
Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. ( 9152609 )
1997
25
Long-term clinical course of two cases of lymphocytic adenohypophysitis. ( 8930533 )
1996
26
Effects of intravenously infused pituitary adenylate cyclase-activating polypeptide on adenohypophyseal Hormone secretion in normal men. ( 8875442 )
1996
27
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. ( 7623353 )
1995
28
Lymphocytic Adenohypophysitis Associated with Rathke's Cleft Cyst. ( 12114815 )
1995
29
Lymphocytic adenohypophysitis: contrast-enhanced MR imaging in five cases. ( 7892490 )
1995
30
Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. ( 7758238 )
1995
31
Immunohistochemical demonstration of adenohypophyseal hormones during postnatal ontogenesis in the Gray Short-tailed Opossum, Monodelphis domestica (marsupialia). ( 8835137 )
1995
32
Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells. ( 7969791 )
1994
33
Adenohypophyseal and sex hormones in pediatric rheumatic diseases. ( 8496873 )
1993
34
[Membrane receptors and coupling proteins in adenohypophyseal cells]. ( 8242419 )
1993
35
Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. ( 1545900 )
1992
36
Lymphocytic adenohypophysitis with sudden onset of diabetes insipidus in menopausal female--case report. ( 1381061 )
1992
37
Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy. Proposal for medical treatment. ( 2048602 )
1991
38
[A case of pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis]. ( 2070891 )
1991
39
Adenohypophysitis associated with sebaceous gland atrophy in a dog. ( 1949513 )
1991
40
Lymphocytic adenohypophysitis presenting as infertility. Case report. ( 2013781 )
1991
41
Lymphocytic adenohypophysitis: an immunohistochemical study. ( 1891758 )
1991
42
Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. ( 2172282 )
1990
43
Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women. ( 2308340 )
1990
44
The effect of oxytocin infusion on adenohypophyseal function in man. ( 2160873 )
1990
45
Lymphocytic adenohypophysitis accompanying occlusion of bilateral internal carotid arteries--case report. ( 1699152 )
1990
46
Lymphocytic adenohypophysitis: report of two cases. ( 2700055 )
1989
47
Lymphocytic adenohypophysitis in a man. ( 3208233 )
1988
48
Lymphocytic adenohypophysitis. ( 3278777 )
1988
49
A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. ( 3215147 )
1988
50
Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. ( 3380286 )
1988

Variations for Adenohypophysitis

Expression for Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for Adenohypophysitis

GO Terms for Adenohypophysitis

Cellular components related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.96 POMC TRH
2 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.43 CD4 IL2RA PRL
2 response to estradiol GO:0032355 9.4 CD4 GH1
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.37 CD4 GH1
4 positive regulation of T cell proliferation GO:0042102 9.32 CD4 IL2RA
5 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 PRL
6 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 PRL
7 regulation of receptor activity GO:0010469 8.92 GH1 POMC PRL TRH

Molecular functions related to Adenohypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 POMC PRL TRH

Sources for Adenohypophysitis

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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36 KEGG
37 LifeMap
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54 OMIM via Orphanet
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
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70 UMLS via Orphanet
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