MCID: ADN064
MIFTS: 35

Adenohypophysitis malady

Endocrine diseases, Rare diseases categories

Summaries for Adenohypophysitis

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MalaCards based summary: Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to thyroiditis and pituitary apoplexy. An important gene associated with Adenohypophysitis is POMC (proopiomelanocortin), and among its related pathways are Development Leptin signaling via JAK STAT and MAPK cascades and Peptide hormone metabolism. The compounds flesinoxan and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and placenta, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Aliases & Classifications for Adenohypophysitis

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Sources:
47Orphanet, 26ICD10 via Orphanet
See all sources

Adenohypophysitis, Aliases & Descriptions:

Name: Adenohypophysitis 47
 
Anterior Pituitary Hypophysitis 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


External Ids:

Orphanet47 95512
ICD10 via Orphanet26 E23.6

Related Diseases for Adenohypophysitis

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Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.4TRH, POMC
2pituitary apoplexy29.9TRH, PRL, POMC
3adenoma29.9POMC, PRL, GH1, TRH
4diabetes insipidus29.9POMC, PRL, TRH
5pituitary adenoma29.9POMC, PRL, GH1, TRH
6precocious puberty29.7GH1, PRL, POMC
7hypopituitarism29.6TRH, GH1, PRL, POMC
8pituitary tumors29.6TRH, GH1, PRL, POMC
9hypothyroidism29.4TRH, GH1, PRL, POMC
10exophthalmos10.4TRH
11hyperthyroxinemia10.4TRH
12euthyroid sick syndrome10.4TRH
13melancholia10.2POMC, TRH
14choristoma10.2
15endogenous depression10.2POMC, TRH
16sheehan syndrome10.1POMC, PRL
17diabetes insipidus, neurohypophyseal10.1POMC, PRL
18nelson syndrome10.1POMC, PRL
19klinefelter's syndrome10.1TRH, PRL
20pituitary carcinoma10.1POMC, PRL
21panic disorder10.1POMC, TRH
22chromophobe adenoma10.1GH1, PRL
23primary hyperoxaluria10.0TRH, POMC
24mccune-albright syndrome, somatic, mosaic10.0PRL, GH1
25pituitary gland disease10.0PRL, GH1
26pituitary gigantism10.0PRL, GH1
27hypothalamic disease10.0PRL, GH1
28mood disorder10.0TRH, POMC
29empty sella syndrome10.0PRL, GH1
30hypersensitivity reaction type ii disease10.0POMC, TRH
31gigantism10.0PRL, GH1
32prostatic hypertrophy10.0GH1, PRL
33alcohol dependence10.0TRH, POMC
34neuronitis10.0
35infertility10.0
36lymphocytic hypophysitis10.0
37rheumatic disease10.0
38polycystic ovary syndrome10.0GH1, PRL
39gonadal disease10.0GH1, POMC
40cushing's syndrome10.0POMC, GH1
41hypoadrenalism10.0POMC, GH1
42neuroendocrine tumor9.9POMC, GH1
43amenorrhea9.9POMC, PRL, TRH
44cholera9.9TRH, POMC
45diabetes mellitus, insulin-dependent9.9TRH, GH1
46carcinoid syndrome9.9GH1, POMC
47hyperglycemia9.8GH1, POMC
48hyperthyroidism9.8PRL, GH1, TRH
49acth deficiency9.8GH1, PRL, POMC
50pituitary-dependent cushing's disease9.8POMC, PRL, GH1

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to adenohypophysitis

Symptoms for Adenohypophysitis

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Drugs & Therapeutics for Adenohypophysitis

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Drug clinical trials:

Search ClinicalTrials for Adenohypophysitis

Search NIH Clinical Center for Adenohypophysitis

Genetic Tests for Adenohypophysitis

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Anatomical Context for Adenohypophysitis

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MalaCards organs/tissues related to Adenohypophysitis:

31
Pituitary, Thyroid, Placenta

Animal Models for Adenohypophysitis or affiliated genes

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MGI Mouse Phenotypes related to Adenohypophysitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5GH1, PRL, POMC
2MP:00053798.0TRH, GH1, PRL, POMC
3MP:00036317.9POMC, PRL, GH1, TRH
4MP:00053767.7TRH, GH1, PRL, POMC

Publications for Adenohypophysitis

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Articles related to Adenohypophysitis:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog. (23204587)
2012
2
Lymphocytic adenohypophysitis and adrenalitis in a dog with adrenal and thyroid atrophy. (20807820)
2010
3
Adenohypophysitis in rat pituitary allografts. (20586813)
2010
4
Relationship of plasma ghrelin and adenohypophyseal hormone levels in female precocious puberty]. (18925720)
2008
5
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: cytoplasmic clusterin localization in adenohypophysis is related to aging. (18239862)
2008
6
Granulomatous adenohypophysitis after interferon and ribavirin therapy. (17490932)
2007
7
Longitudinal study of patients with idiopathic isolated TSH deficiency: possible progression of pituitary dysfunction in lymphocytic adenohypophysitis. (16896268)
2006
8
Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line. (15326563)
2004
9
Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells. (11999717)
2002
10
Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study. (11515793)
2001
11
The regulation of adenohypophyseal prolactin secretion: effect of triiodothyronine and methylene blue on estrogenized rat adenohypophysis. (10984069)
2000
12
Lymphocytic adenohypophysitis mimicking a pituitary macroadenoma. (10926106)
2000
13
Spontaneous recovery from pathologically confirmed lymphocytic adenohypophysitis with a dramatic reduction of hypophyseal size. (10563747)
1999
14
Lymphocytic adenohypophysitis: skull radiographs and MRI. (9541922)
1998
15
Comparative immunohistochemical study of stellate cells in normal canine and equine adenohypophyses and in pituitary tumours. (9500236)
1998
16
Lymphocytic adenohypophysitis and neurohypophysitis. (9187559)
1997
17
Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis. (9152609)
1997
18
Effects of intravenously infused pituitary adenylate cyclase-activating polypeptide on adenohypophyseal Hormone secretion in normal men. (8875442)
1996
19
Long-term clinical course of two cases of lymphocytic adenohypophysitis. (8930533)
1996
20
Lymphocytic adenohypophysitis: magnetic resonance imaging features of two new cases and a review of the literature. (7758238)
1995
21
Differentiating lymphocytic adenohypophysitis from pituitary adenoma in the peripartum patient. (7623353)
1995
22
Lymphocytic Adenohypophysitis Associated with Rathke's Cleft Cyst. (12114815)
1995
23
Immunohistochemical demonstration of adenohypophyseal hormones during postnatal ontogenesis in the Gray Short-tailed Opossum, Monodelphis domestica (marsupialia). (8835137)
1995
24
Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells. (7969791)
1994
25
Membrane receptors and coupling proteins in adenohypophyseal cells]. (8242419)
1993
26
Adenohypophyseal and sex hormones in pediatric rheumatic diseases. (8496873)
1993
27
Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. (1545900)
1992
28
Lymphocytic adenohypophysitis: a pituitary mass lesion occurring in pregnancy. Proposal for medical treatment. (2048602)
1991
29
Lymphocytic adenohypophysitis: an immunohistochemical study. (1891758)
1991
30
Adenohypophysitis associated with sebaceous gland atrophy in a dog. (1949513)
1991
31
A case of pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis]. (2070891)
1991
32
Lymphocytic adenohypophysitis presenting as infertility. Case report. (2013781)
1991
33
Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women. (2308340)
1990
34
Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. (2172282)
1990
35
Lymphocytic adenohypophysitis: report of two cases. (2700055)
1989
36
Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. (3380286)
1988
37
A case of hypopituitarism due to granulomatous and lymphocytic adenohypophysitis with minimal pituitary enlargement: a possible variant of lymphocytic adenohypophysitis. (3215147)
1988
38
Lymphocytic adenohypophysitis. (3278777)
1988
39
Lymphocytic adenohypophysitis in a man. (3208233)
1988
40
Lymphocytic adenohypophysitis. Report of a case with demonstration of spontaneous tumour regression and a review of the literature. (3077051)
1988
41
Lymphocytic adenohypophysitis of pregnancy with complete recovery. (3601028)
1987
42
Lymphoid adenohypophysitis. (3739708)
1986
43
Lymphocytic adenohypophysitis. A review and a case. (4017662)
1985
44
Hypothalamic neuronal hamartoma and adenohypophyseal neuronal choristoma: their association with growth hormone adenoma of the pituitary gland. (6631456)
1983
45
Intrasellar neural-adenohypophyseal choristoma. A morphological and immunocytochemical study. (7042919)
1982
46
Lymphoid adenohypophysitis with radiologic and clinical findings resembling a pituitary tumor. (6810678)
1982
47
Galactorrhea associated with lymphocytic adenohypophysitis. Case report. (7195731)
1981
48
Lymphoid adenohypophysitis presenting as a pituitary tumor. (7424950)
1980
49
Allergic adrenalitis and adenohypophysitis: further observations on production and passive transfer. (5773150)
1969
50
Allergic adenohypophysitis: new experimental disease of the pituitary gland. (6057291)
1967

Variations for Adenohypophysitis

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Expression for genes affiliated with Adenohypophysitis

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Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for genes affiliated with Adenohypophysitis

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Pathways related to Adenohypophysitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4POMC, TRH
2
Show member pathways
9.3GH1, POMC
39.1PRL, POMC
4
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.0PRL, GH1
5
Show member pathways
Type III interferon signaling36
9.0GH1, PRL
6
Show member pathways
9.0GH1, PRL
7
Show member pathways
9.0PRL, GH1
89.0GH1, PRL
9
Show member pathways
8.0TRH, GH1, PRL, POMC
10
Show member pathways
8.0TRH, GH1, PRL, POMC

Compounds for genes affiliated with Adenohypophysitis

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Compounds related to Adenohypophysitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1flesinoxan439.5PRL, POMC
2acth 1-24439.4PRL, POMC
3ipsapirone43 2810.4PRL, POMC
411 deoxycortisol439.4PRL, POMC
5quinagolide439.4PRL, GH1
6betamethasone43 1210.3GH1, POMC
7domperidone43 28 1211.3TRH, PRL
85-hydroxytryptophan439.2GH1, PRL
9leuprolide acetate439.1PRL, GH1
10lanreotide43 2810.1PRL, GH1
11mirtazapine43 49 1211.0PRL, POMC
12clomiphene citrate439.0PRL, GH1
13fenfluramine43 28 1211.0TRH, PRL, POMC
14haloperidol43 49 28 2 1213.0POMC, TRH, PRL
15ghrp438.9TRH, GH1, PRL
16pyridostigmine43 129.9TRH, GH1, PRL
17hexarelin43 289.9POMC, PRL, GH1
18sulpiride43 28 1210.9GH1, TRH, PRL
19naltrexone43 28 49 1211.9POMC, GH1, PRL
20metoclopramide43 49 1210.9GH1, PRL, TRH
21apomorphine28 43 1210.9PRL, GH1, TRH
22cocaine43 129.9POMC, PRL, TRH
23dehydroepiandrosterone sulfate438.9PRL, GH1, POMC
24opiate438.9GH1, PRL, POMC
25dhea438.9POMC, GH1, PRL
26melatonin43 28 59 24 1212.9TRH, GH1, PRL
27androstenedione43 249.9POMC, PRL, GH1
28levodopa43 129.9PRL, TRH, GH1
29corticosterone43 59 2410.9PRL, POMC, GH1
30epinephrine43 24 1210.7POMC, PRL, GH1
31ribonucleic acid438.7POMC, PRL, GH1
32acetylcholine43 49 28 24 1212.5TRH, POMC, GH1
33bromocriptine43 28 1210.4POMC, TRH, GH1, PRL
34naloxone43 28 49 1211.4POMC, PRL, TRH, GH1
35clonidine43 49 28 1211.4POMC, PRL, GH1, TRH
36octreotide43 59 28 1211.4PRL, POMC, TRH, GH1
37triiodothyronine438.4POMC, GH1, TRH, PRL
38hydrocortisone43 2 59 1211.4GH1, TRH, PRL, POMC
39thyroxine43 249.4TRH, POMC, GH1, PRL
40acth438.4TRH, POMC, PRL, GH1
41gnrh438.4POMC, PRL, GH1, TRH
42norepinephrine43 24 1210.4TRH, GH1, PRL, POMC
43estradiol43 24 1210.4PRL, POMC, GH1, TRH
44dopamine43 28 24 1211.4GH1, TRH, PRL, POMC
45progesterone43 28 59 24 1212.4POMC, GH1, TRH, PRL
46testosterone43 59 24 1211.3POMC, GH1, TRH, PRL
47dexamethasone43 49 28 1211.3TRH, GH1, POMC, PRL
48arginine438.3TRH, GH1, PRL, POMC
49estrogen438.3PRL, GH1, POMC, TRH
50glucose438.3TRH, GH1, PRL, POMC

GO Terms for genes affiliated with Adenohypophysitis

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Cellular components related to Adenohypophysitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.4TRH, POMC
2extracellular regionGO:00055767.7TRH, GH1, PRL, POMC

Biological processes related to Adenohypophysitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00072679.4TRH, POMC
2positive regulation of JAK-STAT cascadeGO:00464278.9GH1, PRL
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603978.7GH1, PRL

Molecular functions related to Adenohypophysitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00051488.7GH1, PRL
2hormone activityGO:00051798.5GH1, PRL, POMC

Products for genes affiliated with Adenohypophysitis

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Sources for Adenohypophysitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet