MCID: ADN064
MIFTS: 40

Adenohypophysitis malady

Endocrine diseases category

Summaries for Adenohypophysitis

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MalaCards: Adenohypophysitis, also known as anterior pituitary hypophysitis, is related to adenoma and pituitary adenoma. An important gene associated with Adenohypophysitis is GHRH (growth hormone releasing hormone), and among its related pathways are Glycoprotein hormones and Prolactin receptor signaling. The compounds estrogen and prostaglandin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Aliases & Classifications for Adenohypophysitis

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48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

adenohypophysitis 48
anterior pituitary hypophysitis 48


External Ids:

ICD10 via Orphanet26 E23.6

Related Diseases for Adenohypophysitis

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17GeneCards, 18GeneDecks
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Diseases related to Adenohypophysitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.4ADCYAP1, ENO2, POMC, TRH, SST, SYP
2pituitary adenoma30.4ADCYAP1, ADCY10, ADM, POMC, TRH, SST
3thyroiditis30.1POMC, TRH
4hypopituitarism30.1POMC, TRH, SST, PRL, GH1, GHRH
5pituitary gland disease29.9PRL, GH1
6infertility29.9CLU, PRL, GHRH, GNRH1
7pituitary apoplexy29.9POMC, TRH, PRL, GNRH1
8diabetes insipidus29.9OXT, POMC, TRH, PRL, GHRH
9hypothyroidism29.8ADCY10, OXT, POMC, TRH, PRL, GH1
10thyrotoxicosis10.0TRH
11pituitary hypoplasia10.0GHRH
12goiter10.0TRH
13phaeochromocytoma10.0ADM
14multiple endocrine neoplasia10.0VIP
15melanotic neuroectodermal tumor10.0SYP
16blindness10.0CLU
17essential hypertension10.0ADM
18teratoma10.0ENO2
19eating disorder10.0GHRL
20thymus cancer10.0SYP
21bulimia nervosa10.0GHRL
22cystadenoma10.0CLU
23ileus10.0GHRL
24pneumonia10.0ADM
25endometriosis10.0GNRH1
26cerebral primitive neuroectodermal tumor10.0ENO2
27osteoarthritis10.0CLU
28brain cancer10.0SYP
29endometrial carcinoma10.0GNRH1
30adrenal carcinoma10.0POMC
31scrapie10.0CLU
32systemic lupus erythematosus10.0PRL
33gangliocytoma10.0SYP
34addison's disease10.0POMC
35carney complex10.0POMC
36gastroparesis10.0GHRL
37hemangioma10.0CLU
38cocaine abuse10.0DRD2
39morbid obesity10.0GHRL
40myopathy10.0POMC
41restless legs syndrome10.0DRD2
42dyspepsia10.0GHRL
43subependymal giant cell astrocytoma10.0ENO2, SYP
44epulis10.0ENO2
45cerebrovascular disease10.0ADM, TRH
46pancreatitis10.0SST
47amyotrophic lateral sclerosis10.0SYP
48rhabdoid cancer10.0ENO2
49hepatitis10.0GHR
50diabetic retinopathy10.0ADM

Graphical network of the top 20 diseases related to Adenohypophysitis:



Diseases related to adenohypophysitis

Clinical Features for Adenohypophysitis

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Drugs & Therapeutics for Adenohypophysitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenohypophysitis

Drug clinical trials:

Search ClinicalTrials for Adenohypophysitis

Search NIH Clinical Center for Adenohypophysitis

Search CenterWatch for Adenohypophysitis

Genetic Tests for Adenohypophysitis

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Anatomical Context for Adenohypophysitis

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32MalaCards
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MalaCards organs/tissues related to Adenohypophysitis:

32
Pituitary

Animal Models for Adenohypophysitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenohypophysitis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.9DRD2, GHR, GHRH, OXT
2MP:00053758.9DRD2, GHR, GH1, POMC, ADCYAP1
3MP:00053708.2GNRH1, DRD2, GHR, GHRH, GH1, PRL
4MP:00053677.5GNRH1, DRD2, GHR, POMC, OXT, CLU
5MP:00053787.2GNRH1, DRD2, GHR, GHRH, GH1, SST
6MP:00053877.1GHR, DRD2, GNRH1, VIM, VIP, GHRH
7MP:00053857.1VIP, VIM, DRD2, GHR, POMC, OXT
8MP:00053896.9VIP, VIM, GNRH1, DRD2, GHR, GHRH
9MP:00053866.2GHRL, GHR, DRD2, VIM, VIP, PRL
10MP:00036315.3GH1, GHRH, GHR, DRD2, GNRH1, VIM
11MP:00053765.1ADCYAP1, VIP, VIM, GNRH1, DRD2, GHR

Publications for Adenohypophysitis

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Genetic Variations for Adenohypophysitis

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Expression for genes affiliated with Adenohypophysitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenohypophysitis

Search GEO for disease gene expression data for Adenohypophysitis.

Pathways for genes affiliated with Adenohypophysitis

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Adenohypophysitis

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Adenohypophysitis according to GeneCards/GeneDecks:

(show top 50)    (show all 229)
idCompoundScoreTop Affiliating Genes
1estrogen4410.3TRH
2prostaglandin449.3ADCY10, VIM, VIP, GHRL, ADCYAP1
3glutamate449.3GNRH1, DRD2, GHRL, GHRH, TRH
4cycloheximide449.3TRH, GHRH, GHR, ADCY10
5forskolin44 49 1111.1VIM, GHRH, POMC, ENO2, ADM
6pirenzepine44 28 1111.1ADCY10, DRD2, GHRL, GHRH, GH1, SST
7atropine44 28 1111.1GHRH, GHRL, TRH, ADCY10, ADCYAP1, GH1
8pyridostigmine44 1110.0TRH, SST, PRL, GH1, GHRH, GHRL
9propranolol44 28 49 11 2412.9SST, GHRH, VIP, ADM, GH1, ADCY10
10cabergoline28 44 1110.9GHR, GNRH1, SST, PRL, GH1, DRD2
11creatinine448.9SYP, GHRL, GHR, GNRH1, POMC
12melatonin44 59 28 11 2412.6TRH, GH1, OXT, ADCYAP1, PRL
13ghrp448.5TRH, SST, PRL, GH1, GHRH, GHRL
14dihydrotestosterone44 28 11 2411.4VIM, ADCYAP1, GNRH1, GHR, GH1, PRL
15triiodothyronine448.4GHRL, GHR, PRL, GHRH, TRH, POMC
16gnrh448.3ADCYAP1, CLU, TRH, GH1, GHRH, GHRL
17corticosterone44 59 2410.3GH1, POMC, OXT, ADM, ADCYAP1, VIP
18isoproterenol44 119.3ADCYAP1, ADCY10, ADM, SST, GH1, GNRH1
19hydrocortisone44 2 59 1111.2GHRL, TRH, POMC, GH1, ADM, PRL
20levodopa44 119.2DRD2, TRH, SST, PRL, GHRH, GHR
21nifedipine44 49 28 1111.2SST, ADCYAP1, GH1, OXT, GHRH, VIP
22apomorphine44 28 1110.2DRD2, OXT, ADCYAP1, PRL, GH1, TRH
23clonidine44 28 1110.0GHR, GHRH, GH1, ADCYAP1, ADCY10, POMC
24hexarelin44 289.0OXT, POMC, SST, PRL, GH1, GHRH
25ibmx44 28 5910.0ENO2, ADCY10, SST, GH1, VIP, ADM
26dbc-amp448.0ADCYAP1, ADCY10, ADM, ENO2, TRH, SYP
27bromocriptine28 44 119.9ADCY10, POMC, TRH, SST, PRL, GHRH
28opiate447.9GHRL, DRD2, GNRH1, GHRH, GH1, ADCY10
29ribonucleic acid447.8CLU, POMC, PRL, ENO2, ADCYAP1, GH1
30dexamethasone44 49 28 1110.4ADCYAP1, ADCY10, ENO2, CLU, POMC, TRH
31acetylcholine44 49 28 11 2411.3GH1, GHRL, DRD2, SYP, SST, ADCYAP1
32steroid447.3POMC, CLU, ADM, ADCYAP1, SYP, OXT
33estradiol44 11 249.2VIM, OXT, CLU, POMC, TRH, GNRH1
34epinephrine44 11 249.1ADCYAP1, ADCY10, ADM, OXT, POMC, SST
355-hydroxytryptamine447.1DRD2, GNRH1, VIM, VIP, GHRL, PRL
36norepinephrine44 11 249.0PRL, GHRH, DRD2, GNRH1, VIP, SYP
37thyroxine44 248.0GHRL, GHR, GNRH1, VIP, GHRH, GH1
38lactate447.0OXT, GH1, ENO2, VIP, CLU, VIM
39paraffin447.0VIM, ADM, GH1, ENO2, SYP, GHR
40dopamine44 28 11 249.7ADCYAP1, ENO2, CLU, OXT, TRH, GHRH
41naloxone44 49 28 119.7PRL, GH1, GHRH, GHRL, GNRH1, VIM
42octreotide44 59 28 119.6GHR, DRD2, GNRH1, VIP, GHRL, ADCY10
43vegf446.4VIP, VIM, DRD2, GHRL, GH1, SST
44aspartate446.4OXT, GH1, ENO2, GHRH, GHR, ADCYAP1
45adenylate446.4ADCYAP1, VIM, VIP, GNRH1, DRD2, ADCY10
46gaba446.4ADCYAP1, ENO2, OXT, POMC, TRH, SST
47progesterone44 59 28 11 249.9CLU, GH1, GHRH, GHR, GNRH1, VIM
48acth445.8POMC, VIP, TRH, SST, SYP, PRL
49arginine445.8TRH, SST, PRL, GH1, GHRH, GHRL
50testosterone44 59 11 248.1TRH, POMC, OXT, CLU, ENO2, ADM

GO Terms for genes affiliated with Adenohypophysitis

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16Gene Ontology
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Cellular components related to Adenohypophysitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.9POMC, GHRL
2terminal boutonGO:0431959.2GHRH, OXT, ADCYAP1
3neuronal cell bodyGO:0430258.8ADCY10, SST, GHR, VIP
4secretory granuleGO:0301418.6PRL, TRH, POMC, OXT
5extracellular spaceGO:0056157.0GNRH1, GHR, GHRL, GHRH, GH1, SST
6extracellular regionGO:0055766.0ADCYAP1, VIP, GNRH1, GHR, GHRL, GHRH

Biological processes related to Adenohypophysitis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.3VIP, ADCYAP1
2adenohypophysis developmentGO:02198410.3DRD2, GHRH
3growth hormone secretionGO:03025210.2GHRL, GHRH
4cAMP-mediated signalingGO:01993310.2GHRH, ADM, ADCYAP1
5ovulation cycleGO:04269810.2GNRH1, PRL
6positive regulation of vasodilationGO:04590910.1VIP, ADM, ADCYAP1
7negative regulation of potassium ion transportGO:04326710.1VIP, ADCYAP1
8growth hormone receptor signaling pathwayGO:06039610.0GHR, GH1
9positive regulation of JAK-STAT cascadeGO:04642710.0PRL, GH1
10response to foodGO:03209410.0GHRH, GHR
11cAMP biosynthetic processGO:0061719.9ADM, ADCY10
12positive regulation of growth hormone secretionGO:0601249.9ADCYAP1, GHRH, GHRL, DRD2
13G-protein coupled receptor internalizationGO:0020319.9DRD2, ADM
14JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.9GHR, GH1, PRL
15positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.8GH1, GHRH
16response to ethanolGO:0454719.6GNRH1, PRL, TRH, ADCYAP1
17hormone-mediated signaling pathwayGO:0097559.6TRH, GHRL, GHR
18positive regulation of multicellular organism growthGO:0400189.4DRD2, GHR, GHRL, GHRH, GH1
19elevation of cytosolic calcium ion concentrationGO:0072049.3GHRL, OXT, ADM, ADCYAP1
20response to glucocorticoid stimulusGO:0513849.2ADM, OXT, GHR
21response to estradiol stimulusGO:0323559.1OXT, PRL, GH1, GHR
22female pregnancyGO:0075659.1GNRH1, PRL, OXT, ADM, ADCYAP1
23cell-cell signalingGO:0072678.2ADCYAP1, GNRH1, GHRH, SST, TRHDE, TRH
24signal transductionGO:0071657.9GNRH1, TRHDE, TRH, POMC, OXT, ADM

Molecular functions related to Adenohypophysitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.0PRL, GH1
2growth hormone-releasing hormone activityGO:0166089.7GHRH, GHRL
3neuropeptide hormone activityGO:0051849.4VIP, TRH, ADCYAP1
4hormone activityGO:0051798.6ADM, POMC, SST, PRL, GH1, GNRH1

Products for genes affiliated with Adenohypophysitis

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Sources for Adenohypophysitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet