MCID: ADN011
MIFTS: 58

Adenoid Cystic Carcinoma malady

Cancer diseases category

Summaries for Adenoid Cystic Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Adenoid cystic carcinoma is a rare form of adenocarcinoma (a cancer that arises from gladular tissue). adenoid cystic carcinoma is found mainly in the head and neck, but can occasionally occur in a woman’s uterus or other sites in the body. it most commonly occurs in the salivary glands, in locations such as the palate (the roof of the mouth), nasopharynx (air passageway at the upper part of the throat and behind the nose), inner lining of the mouth, larynx, or trachea. symptoms may include difficulty swallowing, hoarseness, dull pain, numbness or palpable lumps. regardless of its location, adenoid cystic carcinoma tends to spread along nerves or through the bloodstream. a small percentage of cases spread to the lymph nodes. the most common location for metatasis is the lung. adenoid cystic carcinoma is often unpredictable, with long periods of no activity followed by rapid growth. the cause of adenoid cystic carcinoma is not known and no specific risk factors have been identified. treatment depends on the size and location of the tumor, whether the cancer has spread, and the patient's overall health, but may include surgery, radiation or chemotherapy. last updated: 1/15/2009

MalaCards: Adenoid Cystic Carcinoma, also known as cylindroma, is related to adenocarcinoma and adenoma. An important gene associated with Adenoid Cystic Carcinoma is ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)), and among its related pathways are Apoptosis and Autophagy and C-MYB transcription factor network. The compounds retinoic acid and progesterone have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, lung and breast, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology:8 A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. these structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

Wikipedia:63 Adenoid cystic carcinoma (AdCC) is a rare type of cancer that can exist in many different body sites. It... more...

Aliases & Classifications for Adenoid Cystic Carcinoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenoid cystic carcinoma 8 42 10 60
cylindroma 8 42
carcinoma adenoid cystic 44
adenoid cystic cancer 8
adenocystic carcinoma 42
cribriform carcinoma 42
cylindroma nos 8


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Disease Ontology8 DOID:4866
NCIt39 C2970
MeSH34 D003528

Related Diseases for Adenoid Cystic Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.3BCL2, SPN, SERPINB5, MMP15, MYB, RUNX3
2adenoma31.1RUNX3, SERPINB5, BCL2, SPN
3squamous cell carcinoma30.9BCL2, SERPINB5, MYB, LBX1, RUNX3, SNAI2
4melanoma30.6SERPINB5, BIRC7, MYB, SNAI2, BCL2, KIT
5breast cancer30.2MMP15, TFAP2C, MYB, SNAI2, RUNX3, SERPINB5
6adenoiditis11.6
7breast adenoid cystic carcinoma11.0
8lacrimal gland adenoid cystic carcinoma10.9
9lung adenoid cystic carcinoma10.8
10trachea adenoid cystic carcinoma10.8
11pleomorphic adenoma10.7
12pleomorphic adenoma carcinoma10.7
13pleomorphic carcinoma10.7
14maxillary sinus adenoid cystic carcinoma10.7
15bartholin's gland adenoid cystic carcinoma10.7
16cervical adenoid cystic carcinoma10.6
17laryngeal adenoid cystic carcinoma10.6
18bartholin's gland carcinoma10.6
19adenoid squamous cell carcinoma10.6
20mucoepidermoid carcinoma10.6
21laryngeal carcinoma10.5
22laryngitis10.5
23bone carcinoma10.5
24cystic basal cell carcinoma10.5
25adenoid basal cell carcinoma10.5
26prostate adenoid cystic carcinoma10.5
27esophageal adenoid cystic carcinoma10.5
28basal cell carcinoma10.5
29ethmoid sinus adenoid cystic carcinoma10.5
30papillary carcinoma10.5
31small cell carcinoma10.5
32nasopharynx carcinoma10.5
33cervicitis10.5
34familial cylindromatosis10.4
35basaloid squamous cell carcinoma10.4
36nasopharyngitis10.4
37cystic kidney10.4
38paranasal sinus cancer10.4
39thyroiditis10.4
40adenoid cystic carcinoma of the corpus uteri10.4
41dermal eccrine cylindroma10.4
42neuroendocrine carcinoma10.3
43cerebritis10.3
44maxillary sinus adenocarcinoma10.3
45spiradenoma10.3
46epithelial-myoepithelial carcinoma10.3
47hepatitis10.3
48lacrimal gland cancer10.3
49lung adenocarcinoma10.3
50renal cell carcinoma10.3

Graphical network of the top 20 diseases related to Adenoid Cystic Carcinoma:



Diseases related to adenoid cystic carcinoma

Clinical Features for Adenoid Cystic Carcinoma

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Drugs & Therapeutics for Adenoid Cystic Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Adenoid Cystic Carcinoma

Drug clinical trials:

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Search NIH Clinical Center for Adenoid Cystic Carcinoma

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Genetic Tests for Adenoid Cystic Carcinoma

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Anatomical Context for Adenoid Cystic Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Adenoid Cystic Carcinoma:

32
Salivary gland, Lung, Breast, Trachea, Lymph node, Brain, Uterus, Eye, Tongue, Cervix, Liver, Skin, Endothelial, Prostate, Bone, Thyroid, Kidney, Smooth muscle, Tonsil, Pancreas, Testis, Skeletal muscle, Thymus, Spinal cord, Testes

Animal Models for Adenoid Cystic Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenoid Cystic Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.5AQP5, RUNX3, LBX1, MFN2, TFAP2C, PIR
2MP:001076811.4SNAI2, TFAP2C, MFN2, LBX1, RUNX3, MYB
3MP:000538011.3LBX1, MFN2, TFAP2C, PIR, SNAI2, MYB
4MP:000538411.2RUNX3, LBX1, MFN2, SNAI2, MYB, KIT
5MP:000538611.0RUNX3, LBX1, MFN2, SNAI2, KIT, RAX
6MP:000287311.0LBX1, MFN2, TFAP2C, MYB, MMP15, KIT
7MP:000363110.8LBX1, MFN2, KIT, RAX, EN1, ASIC1
8MP:000537910.7RUNX3, MMP15, KIT, EN1, BCL2
9MP:000118610.7MFN2, EN1
10MP:000536910.7AQP5, MFN2, LBX1, RUNX3
11MP:000538110.5RUNX3, SNAI2, KIT, RAX, BCL2, AQP5

Publications for Adenoid Cystic Carcinoma

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50PubMed
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Articles related to Adenoid Cystic Carcinoma:

(show top 50)    (show all 701)
idTitleAuthorsYear
1
Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma. (24370995)
2013
2
Adenoid cystic carcinoma of palate: A case report and review of literature. (23946749)
2013
3
Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study. (23784851)
2013
4
PLAG1 and CYLD do not play a role in the tumorigenesis of adenoid cystic carcinoma. (23404581)
2013
5
Prognostic significance of PDCD4 expression in human salivary adenoid cystic carcinoma. (23389919)
2013
6
Suppression of NF-I_B activity by mutant II_BI+: A molecular target for radiosensitization of adenoid cystic carcinoma. (23599797)
2013
7
Management of nasopharyngeal adenoid cystic carcinoma. (23507327)
2013
8
ALDH1 immunohistochemical expression and its significance in salivary adenoid cystic carcinoma. (22581680)
2013
9
Adenoid cystic carcinoma of the salivary gland: a clinicopathological study of 49 cases and of metallothionein expression with regard to tumour behaviour. (24102890)
2013
10
Clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with adenoid cystic carcinoma. (23516127)
2013
11
Expression of TMPRSS4 in patients with salivary adenoid cystic carcinoma: correlation with clinicopathological features and prognosis. (24132607)
2013
12
Concurrent chemoradiation for adenoid cystic carcinoma of the head and neck. (22083968)
2012
13
Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance. (23110497)
2012
14
Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico. (23243344)
2012
15
Intravascular papillary endothelial hyperplasia of the palate masquerading as adenoid cystic carcinoma on fine needle aspiration cytology: a potential diagnostic pitfall. (21385237)
2012
16
Metastatic adenoid cystic carcinoma of the eyelid. (22366665)
2012
17
Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas. (22096672)
2011
18
Adenoid cystic carcinoma associated with mucous retention cyst of the parotid gland. (21959473)
2011
19
AIRP best cases in radiologic-pathologic correlation: adenoid cystic carcinoma of the trachea. (21918054)
2011
20
Adenoid cystic carcinoma, low-differentiation carcinoma, squamous cell carcinoma: a rare evolution of a tracheal malignancy within 27 years. (21464410)
2011
21
Determinants and patterns of survival in adenoid cystic carcinoma of the head and neck, including an analysis of adjuvant radiation therapy. (20177363)
2011
22
Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005. (20447723)
2010
23
Adenoid cystic carcinoma of buccal mucosa. (22190804)
2010
24
Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma. (20596622)
2010
25
Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. (20484154)
2010
26
Adenoid cystic carcinoma of the parotid with facial nerve invasion. (20415214)
2010
27
ALDH high adenoid cystic carcinoma cells display cancer stem cell properties and are responsible for mediating metastasis. (20450887)
2010
28
As2O3 may be a treatment option for adenoid cystic carcinoma of salivary gland. (20656411)
2010
29
Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma. (20136697)
2010
30
Differential expression of galectin-3, beta-catenin, and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (19659475)
2009
31
Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands. (20041111)
2009
32
Central adenoid cystic carcinoma of the mandible with odontogenic features: Report of a case. (19189335)
2009
33
Subglottic adenoid cystic carcinoma mistaken for asthma. (19735105)
2009
34
Effects of basic fibroblast growth factor on the proliferation of human salivary adenoid cystic carcinoma cell line ACC-2 and extracellular signal-regulated kinase, Cyclin D1, p2waf/cip1 signaling pathway]. (18605443)
2008
35
Adenoid cystic carcinoma metastatic to the kidney: a case report. (18499998)
2008
36
Skull base invasion of adenoid cystic carcinoma of the lacrimal gland : a case report. (19096692)
2008
37
Aberrant cytokine expression in serum of patients with adenoid cystic carcinoma and squamous cell carcinoma of the head and neck. (17111427)
2007
38
Unusual presentation of adenoid cystic carcinoma mimicking a dentoalveolar fistula. (17507122)
2007
39
Adenoid cystic carcinoma of the parotid gland presenting as temporal bone neoplasm: a case report. (17970441)
2007
40
A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-kappaB activation. (18028781)
2007
41
Expression of Pin1, beta-catenin and cyclin D1 in salivary adenoid cystic carcinoma and its significance]. (17129455)
2006
42
Aberrant expression of beta-catenin, Pin1 and cylin D1 in salivary adenoid cystic carcinoma: relation to tumor proliferation and metastasis. (16865250)
2006
43
Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells]. (16836907)
2006
44
Expression of IgSF in salivary adenoid cystic carcinoma and its relationship with invasion and metastasis. (15817073)
2005
45
Cyclin D1 expression does not effect cell proliferation in adenoid cystic carcinoma of the salivary gland. (14714130)
2004
46
Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma. (15044918)
2004
47
Cyclooxygenase-2 expression in an adenoid cystic carcinoma of the uterine cervix. (11496309)
2001
48
Estrogen receptor assay in polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma of salivary gland origin. An immunohistochemical study. (8108094)
1994
49
All that palsies is not Bell's: Bell's palsy due to adenoid cystic carcinoma of the parotid. (1665012)
1991
50
Adenoid cystic basal cell carcinoma (adenocarcinoma); report of a case. (14815934)
1951

Genetic Variations for Adenoid Cystic Carcinoma

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Expression for genes affiliated with Adenoid Cystic Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoid Cystic Carcinoma

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Pathways for genes affiliated with Adenoid Cystic Carcinoma

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4Cell Signaling Technology, 37NCBI BioSystems Database
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Pathways related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7BCL2, SERPINB5, BIRC7, PIR, TFAP2C
210.6MYB, KIT, BCL2
3
Hide members
10.6BCL2, KIT, SNAI2
410.6BCL2, SERPINB5, SNAI2

Compounds for genes affiliated with Adenoid Cystic Carcinoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.0RUNX3, LBX1, TFAP2C, MYB, KIT, SPN
2progesterone44 59 28 11 2414.9MYB, MMP15, KIT, SERPINB5, BCL2
3estrogen4410.8AQP5, TFAP2C
4vegf4410.8BCL2, SERPINB5, KIT, MYB, RUNX3
5doxorubicin44 49 1112.7MYB, BIRC7, KIT, BCL2
6oligonucleotide4410.7BCL2, KIT, MYB, LBX1, RUNX3
7serine4410.6BIRC7, RUNX3
8paraffin4410.4KIT, SERPINB5, SPN, BCL2

GO Terms for genes affiliated with Adenoid Cystic Carcinoma

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16Gene Ontology
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Cellular components related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.1BCL2, LBX1, TFAP2C, PIR, SNAI2, IMP3

Biological processes related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pigmentationGO:04347310.8EN1, KIT, SNAI2
2male gonad developmentGO:00858410.7BCL2, KIT, TFAP2C
3lymphoid progenitor cell differentiationGO:00232010.7BCL2, KIT
4negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.6BCL2, SNAI2
5response to acidGO:00110110.6ASIC1, BCL2
6camera-type eye morphogenesisGO:04859310.5AQP5, MFN2
7negative regulation of anoikisGO:200081110.3BCL2, SNAI2

Molecular functions related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9AQP5, RUNX3, MFN2, TFAP2C, PIR, MYB
2sequence-specific DNA binding transcription factor activityGO:00370010.8LBX1, TFAP2C, MYB, RAX, PA2G4, EN1

Products for genes affiliated with Adenoid Cystic Carcinoma

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Sources for Adenoid Cystic Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
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57SNOMED-CT via Orphanet
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