MCID: ADN011
MIFTS: 58

Adenoid Cystic Carcinoma malady

Cancer diseases category

Summaries for Adenoid Cystic Carcinoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Adenoid cystic carcinoma is a rare form of adenocarcinoma (a cancer that arises from gladular tissue). adenoid cystic carcinoma is found mainly in the head and neck, but can occasionally occur in a woman’s uterus or other sites in the body. it most commonly occurs in the salivary glands, in locations such as the palate (the roof of the mouth), nasopharynx (air passageway at the upper part of the throat and behind the nose), inner lining of the mouth, larynx, or trachea. symptoms may include difficulty swallowing, hoarseness, dull pain, numbness or palpable lumps. regardless of its location, adenoid cystic carcinoma tends to spread along nerves or through the bloodstream. a small percentage of cases spread to the lymph nodes. the most common location for metatasis is the lung. adenoid cystic carcinoma is often unpredictable, with long periods of no activity followed by rapid growth. the cause of adenoid cystic carcinoma is not known and no specific risk factors have been identified. treatment depends on the size and location of the tumor, whether the cancer has spread, and the patient's overall health, but may include surgery, radiation or chemotherapy. last updated: 1/15/2009

MalaCards: Adenoid Cystic Carcinoma, also known as cylindroma, is related to adenocarcinoma and adenoma. An important gene associated with Adenoid Cystic Carcinoma is ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)), and among its related pathways are Apoptosis and Autophagy and C-MYB transcription factor network. The compounds retinoic acid and progesterone have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, lung and breast, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology:8 A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. these structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

Wikipedia:63 Adenoid cystic carcinoma (AdCC) is a rare type of cancer that can exist in many different body sites. It... more...

Aliases & Classifications for Adenoid Cystic Carcinoma

About this section
Sources:
42NIH Rare Diseases, 8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT, 34MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenoid cystic carcinoma 8 42 10 60
cylindroma 8 42
carcinoma adenoid cystic 44
adenoid cystic cancer 8
adenocystic carcinoma 42
cribriform carcinoma 42
cylindroma nos 8


External Ids:

Disease Ontology8 DOID:4866
NCIt39 C2970
MeSH34 D003528

Related Diseases for Adenoid Cystic Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.3BCL2, SPN, SERPINB5, MMP15, MYB, RUNX3
2adenoma31.1RUNX3, SERPINB5, BCL2, SPN
3squamous cell carcinoma30.9BCL2, SERPINB5, MYB, LBX1, RUNX3, SNAI2
4melanoma30.6SERPINB5, BIRC7, MYB, SNAI2, BCL2, KIT
5breast cancer30.2MMP15, TFAP2C, MYB, SNAI2, RUNX3, SERPINB5
6adenoiditis11.6
7breast adenoid cystic carcinoma11.0
8lacrimal gland adenoid cystic carcinoma10.9
9lung adenoid cystic carcinoma10.8
10trachea adenoid cystic carcinoma10.8
11pleomorphic adenoma10.7
12pleomorphic adenoma carcinoma10.7
13pleomorphic carcinoma10.7
14maxillary sinus adenoid cystic carcinoma10.7
15bartholin's gland adenoid cystic carcinoma10.7
16cervical adenoid cystic carcinoma10.6
17laryngeal adenoid cystic carcinoma10.6
18bartholin's gland carcinoma10.6
19adenoid squamous cell carcinoma10.6
20mucoepidermoid carcinoma10.6
21laryngeal carcinoma10.5
22laryngitis10.5
23bone carcinoma10.5
24cystic basal cell carcinoma10.5
25adenoid basal cell carcinoma10.5
26prostate adenoid cystic carcinoma10.5
27esophageal adenoid cystic carcinoma10.5
28basal cell carcinoma10.5
29ethmoid sinus adenoid cystic carcinoma10.5
30papillary carcinoma10.5
31small cell carcinoma10.5
32nasopharynx carcinoma10.5
33cervicitis10.5
34familial cylindromatosis10.4
35basaloid squamous cell carcinoma10.4
36nasopharyngitis10.4
37cystic kidney10.4
38paranasal sinus cancer10.4
39thyroiditis10.4
40adenoid cystic carcinoma of the corpus uteri10.4
41dermal eccrine cylindroma10.4
42neuroendocrine carcinoma10.3
43cerebritis10.3
44maxillary sinus adenocarcinoma10.3
45spiradenoma10.3
46epithelial-myoepithelial carcinoma10.3
47hepatitis10.3
48lacrimal gland cancer10.3
49lung adenocarcinoma10.3
50renal cell carcinoma10.3

Graphical network of the top 20 diseases related to Adenoid Cystic Carcinoma:



Diseases related to adenoid cystic carcinoma

Clinical Features for Adenoid Cystic Carcinoma

About this section

Drugs & Therapeutics for Adenoid Cystic Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adenoid Cystic Carcinoma

Drug clinical trials:

Search ClinicalTrials for Adenoid Cystic Carcinoma

Search NIH Clinical Center for Adenoid Cystic Carcinoma

Search CenterWatch for Adenoid Cystic Carcinoma

Genetic Tests for Adenoid Cystic Carcinoma

About this section

Anatomical Context for Adenoid Cystic Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Adenoid Cystic Carcinoma:

32
Salivary gland, Lung, Breast, Trachea, Lymph node, Brain, Uterus, Eye, Tongue, Cervix, Liver, Skin, Endothelial, Bone, Prostate, Kidney, Thyroid, Smooth muscle, Thymus, Spinal cord, Testis, Testes, Tonsil, Pancreas, Skeletal muscle

Animal Models for Adenoid Cystic Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Adenoid Cystic Carcinoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.5AQP5, RUNX3, LBX1, MFN2, TFAP2C, PIR
2MP:001076811.4SNAI2, TFAP2C, MFN2, LBX1, RUNX3, MYB
3MP:000538011.3LBX1, MFN2, TFAP2C, PIR, SNAI2, MYB
4MP:000538411.2RUNX3, LBX1, MFN2, SNAI2, MYB, KIT
5MP:000538611.0RUNX3, LBX1, MFN2, SNAI2, KIT, RAX
6MP:000287311.0LBX1, MFN2, TFAP2C, MYB, MMP15, KIT
7MP:000363110.8LBX1, MFN2, KIT, RAX, EN1, ASIC1
8MP:000537910.7RUNX3, MMP15, KIT, EN1, BCL2
9MP:000118610.7MFN2, EN1
10MP:000536910.7AQP5, MFN2, LBX1, RUNX3
11MP:000538110.5RUNX3, SNAI2, KIT, RAX, BCL2, AQP5

Publications for Adenoid Cystic Carcinoma

About this section
Sources:
50PubMed
See all sources

Articles related to Adenoid Cystic Carcinoma:

(show top 50)    (show all 701)
idTitleAuthorsYear
1
High grade transformation in a case of adenoid cystic carcinoma associated with Epstein-Barr virus expression. (24247629)
2013
2
Adenoid cystic carcinoma of the external auditory canal associated with cholesteatoma in an 8-year-old girl. (23073170)
2013
3
Sinonasal adenoid cystic carcinoma: systematic review of survival and treatment strategies. (23064210)
2013
4
Adenoid cystic carcinoma of the maxillary sinus: CT and MR imaging findings. (24057204)
2013
5
Primary adenoid cystic carcinoma of the breast: Case report and review of the literature. (23339984)
2013
6
MicroRNA-181a suppresses salivary adenoid cystic carcinoma metastasis by targeting MAPK-Snai2 pathway. (23911747)
2013
7
Usefulness of the melanoma antigen gene (MAGE) in making the differential diagnosis between pleomorphic adenoma and adenoid cystic carcinoma. (22498264)
2012
8
Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. (21551254)
2011
9
Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: a meta-analytic study. (21743416)
2011
10
Development and characterization of xenograft model systems for adenoid cystic carcinoma. (21709671)
2011
11
Critical regions and spreading of runt-related transcription factor-3 C-phosphate-G (CpG) island methylation in human salivary gland adenoid cystic carcinoma. (21658745)
2011
12
CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. (21692051)
2011
13
Adenoid cystic carcinoma of the Bartholin's gland: case report and systematic review of the literature. (22053678)
2011
14
Unique presentation of adenoid cystic carcinoma in postcricoid region: a case report and review of the literature. (21559806)
2011
15
Bilateral tonsillar adenoid cystic carcinoma. (22134294)
2011
16
Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-I_B pathways through a crossed phosphatidylinositol 3-kinase/Akt/II_B kinase complex signaling axis in adenoid cystic carcinoma. (20959361)
2011
17
Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. (21976542)
2011
18
RUNX3 expression and its methylation of 5'-CpG island in salivary gland adenoid cystic carcinoma cell lines ACC-2, ACC-3 and ACC-M]. (21223819)
2010
19
Adenoid cystic carcinoma of the subglottic larynx: a case report and review of the literature. (20397134)
2010
20
Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: its implication in tumor progression and angiogenesis. (20851535)
2010
21
Thoracoscopic management including lobectomy for a primary peripheral pulmonary adenoid cystic carcinoma in a cirrhotic patient. (20975497)
2010
22
RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells. (20422344)
2010
23
Liver metastasis in a case of adenoid cystic carcinoma of the Bartholin's gland: a rare presentation. (18800221)
2009
24
The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma. (20025737)
2009
25
Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland. (19644550)
2009
26
Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma. (19688981)
2009
27
Unusual presentation of adenoid cystic carcinoma of the maxillary antrum. (20163054)
2009
28
Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. (19557180)
2009
29
Effects of genistein on the expressions of cell apoptosis-related proteins in salivary adenoid cystic carcinoma cell line SACC-83]. (18470428)
2008
30
Macroglossia caused by adenoid cystic carcinoma. Case report. (18521061)
2008
31
Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma. (19036131)
2008
32
Adenoid cystic carcinoma of sublingual gland involving the submandibular duct. (18812607)
2008
33
Multifocal adenoid cystic carcinoma of the breast: an unusual presentation. (18377738)
2008
34
Secretion of collagen I and tenascin is modulated by laminin-111 in 3D culture of human adenoid cystic carcinoma cells. (18336527)
2008
35
Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion. (17982624)
2007
36
Effects of Genistein on the proliferation and expression of survivin in salivary adenoid cystic carcinoma cell line SACC-83]. (17375591)
2007
37
Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands. (17761983)
2007
38
Lung, bone, skeletal muscles and cutaneous metastases from adenoid cystic carcinoma of the parotid gland: a case report and review of the literature. (17917100)
2007
39
Medical image. A case of adenoid cystic carcinoma of the lacrimal gland: MRI findings. (17653256)
2007
40
Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue. (20614269)
2007
41
Adenoid cystic carcinoma of the dorsum of the tongue: presentation of a case. (16878059)
2006
42
Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands. (16135502)
2005
43
Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma". (16325513)
2005
44
The relation of nuclear factor kappa B to angiogenesis and clinical outcomes in adenoid cystic carcinoma of salivary glands]. (16329838)
2005
45
Differential expression of basement membrane type-IV collagen alpha1, alpha2, alpha5 and alpha6 chains among the histological subtypes of adenoid cystic carcinoma. (15138813)
2004
46
Argyrophilia in nucleolar organizer regions (AgNOR) in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of the salivary glands. (7690237)
1993
47
Expression of alveolar type II cell markers in acinar adenocarcinomas and adenoid cystic carcinomas arising from segmental bronchi. A study in a heterotopic bronchogenic carcinoma model in dogs. (8386445)
1993
48
Immunohistochemical localization of estradiol, progesterone, and progesterone receptor in human salivary glands and salivary adenoid cystic carcinomas. (1322800)
1992
49
Expressions of oncogene products in adenoid cystic carcinomas of salivary glands: immunohistochemical study]. (1665502)
1991
50
A comparative immunohistochemical study of adenoid cystic carcinoma of the skin and salivary glands. (1709341)
1991

Genetic Variations for Adenoid Cystic Carcinoma

About this section

Expression for genes affiliated with Adenoid Cystic Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Adenoid Cystic Carcinoma.

Pathways for genes affiliated with Adenoid Cystic Carcinoma

About this section
Sources:
4Cell Signaling Technology, 37NCBI BioSystems Database
See all sources

Pathways related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7BCL2, SERPINB5, BIRC7, PIR, TFAP2C
210.6MYB, KIT, BCL2
3
Hide members
10.6BCL2, KIT, SNAI2
410.6BCL2, SERPINB5, SNAI2

Compounds for genes affiliated with Adenoid Cystic Carcinoma

About this section
Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB
See all sources

Compounds related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid44 2412.0RUNX3, LBX1, TFAP2C, MYB, KIT, SPN
2progesterone44 59 28 11 2414.9MYB, MMP15, KIT, SERPINB5, BCL2
3estrogen4410.8AQP5, TFAP2C
4vegf4410.8BCL2, SERPINB5, KIT, MYB, RUNX3
5doxorubicin44 49 1112.7MYB, BIRC7, KIT, BCL2
6oligonucleotide4410.7BCL2, KIT, MYB, LBX1, RUNX3
7serine4410.6BIRC7, RUNX3
8paraffin4410.4KIT, SERPINB5, SPN, BCL2

GO Terms for genes affiliated with Adenoid Cystic Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.1BCL2, LBX1, TFAP2C, PIR, SNAI2, IMP3

Biological processes related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pigmentationGO:04347310.8EN1, KIT, SNAI2
2male gonad developmentGO:00858410.7BCL2, KIT, TFAP2C
3lymphoid progenitor cell differentiationGO:00232010.7BCL2, KIT
4negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.6BCL2, SNAI2
5response to acidGO:00110110.6ASIC1, BCL2
6camera-type eye morphogenesisGO:04859310.5AQP5, MFN2
7negative regulation of anoikisGO:200081110.3BCL2, SNAI2

Molecular functions related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9AQP5, RUNX3, MFN2, TFAP2C, PIR, MYB
2sequence-specific DNA binding transcription factor activityGO:00370010.8LBX1, TFAP2C, MYB, RAX, PA2G4, EN1

Products for genes affiliated with Adenoid Cystic Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenoid Cystic Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet