MCID: ADN011
MIFTS: 57

Adenoid Cystic Carcinoma malady

Rare diseases, Cancer diseases categories

Summaries for Adenoid Cystic Carcinoma

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Adenoid cystic carcinoma is a rare form of adenocarcinoma (a cancer that arises from gladular tissue). adenoid cystic carcinoma is found mainly in the head and neck, but can occasionally occur in a woman’s uterus or other sites in the body. it most commonly occurs in the salivary glands, in locations such as the palate (the roof of the mouth), nasopharynx (air passageway at the upper part of the throat and behind the nose), inner lining of the mouth, larynx, or trachea. symptoms may include difficulty swallowing, hoarseness, dull pain, numbness or palpable lumps. regardless of its location, adenoid cystic carcinoma tends to spread along nerves or through the bloodstream. a small percentage of cases spread to the lymph nodes. the most common location for metatasis is the lung. adenoid cystic carcinoma is often unpredictable, with long periods of no activity followed by rapid growth. the cause of adenoid cystic carcinoma is not known and no specific risk factors have been identified. treatment depends on the size and location of the tumor, whether the cancer has spread, and the patient's overall health, but may include surgery, radiation or chemotherapy. last updated: 1/15/2009

MalaCards: Adenoid Cystic Carcinoma, also known as cylindroma, is related to adenocarcinoma and melanoma. An important gene associated with Adenoid Cystic Carcinoma is ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)), and among its related pathways are Melanocyte Development and Pigmentation and IL2 signaling events mediated by PI3K. The compounds methylcellulose and imatinib have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, lung and breast, and related mouse phenotypes are digestive/alimentary and vision/eye.

Disease Ontology:9 A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. these structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

Wikipedia:66 Adenoid cystic carcinoma (AdCC) is a rare type of cancer that can exist in many different body sites. It... more...

Aliases & Classifications for Adenoid Cystic Carcinoma

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44NIH Rare Diseases, 9Disease Ontology, 11DISEASES, 63UMLS, 46Novoseek, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

adenoid cystic carcinoma 9 44 11 63
cylindroma 9 44
carcinoma adenoid cystic 46
adenocystic carcinoma 44
adenoid cystic cancer 9
cribriform carcinoma 44
cylindroma nos 9


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Disease Ontology9 DOID:4866
NCIt41 C2970
MeSH36 D003528

Related Diseases for Adenoid Cystic Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1RUNX3, PIN1, CYR61, EFNA1, MYB, BCL2
2melanoma30.4CYR61, EFNA1, MYB, SNAI2, BCL2, BIRC7
3adenoiditis11.6
4polymorphous low-grade adenocarcinoma10.9
5cribriform carcinoma10.8
6adenoma10.8
7pleomorphic adenoma10.8
8lacrimal gland adenoid cystic carcinoma10.8
9cervical adenoid cystic carcinoma10.7
10laryngeal adenoid cystic carcinoma10.7
11mucoepidermoid carcinoma10.6
12maxillary sinus adenoid cystic carcinoma10.6
13endotheliitis10.6
14trachea adenoid cystic carcinoma10.5
15esophageal adenoid cystic carcinoma10.5
16laryngitis10.5
17ethmoid sinus adenoid cystic carcinoma10.5
18lung adenoid cystic carcinoma10.5
19breast adenoid cystic carcinoma10.5
20bartholin's gland adenoid cystic carcinoma10.5
21prostate adenoid cystic carcinoma10.5
22cervicitis10.5
23familial cylindromatosis10.4
24nasopharyngitis10.4
25paranasal sinus cancer10.4
26thyroiditis10.4
27adenoid cystic carcinoma of the corpus uteri10.4
28oral squamous cell carcinoma10.3
29basaloid squamous cell carcinoma10.3
30spiradenoma10.3
31adenoid basal cell carcinoma10.3
32epithelial-myoepithelial carcinoma10.3
33cerebritis10.3
34small cell carcinoma10.3
35basal cell carcinoma10.3
36hepatitis10.3
37lung adenocarcinoma10.3
38renal cell carcinoma10.3
39hypoxia10.3
40sinusitis10.3
41poncet-spiegler's cylindroma10.3
42adnexal spiradenoma/cylindroma of a sweat gland10.2
43ankylosing spondylitis10.2
44myoepithelioma10.2
45neuronitis10.2
46necrotizing sialometaplasia10.2
47sialolithiasis10.2
48spindle cell carcinoma10.2
49ceruminous carcinoma10.2
50sialadenitis10.2

Graphical network of the top 20 diseases related to Adenoid Cystic Carcinoma:



Diseases related to adenoid cystic carcinoma

Symptoms for Adenoid Cystic Carcinoma

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Drugs & Therapeutics for Adenoid Cystic Carcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Adenoid Cystic Carcinoma

Drug clinical trials:

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Search NIH Clinical Center for Adenoid Cystic Carcinoma

Search CenterWatch for Adenoid Cystic Carcinoma

Genetic Tests for Adenoid Cystic Carcinoma

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Anatomical Context for Adenoid Cystic Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Adenoid Cystic Carcinoma:

34
Salivary gland, Lung, Breast, Trachea, Lymph node, Brain, Uterus, Eye, Tongue, Liver, Skin, Endothelial, Cervix, Bone, Kidney, Thyroid, Smooth muscle, Prostate, Testis, Testes, Spinal cord, Tonsil, Pancreas, Skeletal muscle, Thymus

Animal Models for Adenoid Cystic Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adenoid Cystic Carcinoma:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9RUNX3, AQP5, SNAI2, BCL2, RAX, KIT
2MP:00053918.8PIN1, AQP5, SNAI2, BCL2, RAX, KIT
3MP:00053798.7RUNX3, PIN1, AQP5, SNAI2, BCL2, KIT
4MP:00107718.6RUNX3, PIN1, MYB, SNAI2, BCL2, KIT
5MP:00053698.3RUNX3, LBX1, AQP5, EFNA1, BCL2, KIT
6MP:00053808.2LBX1, CYR61, MYB, SNAI2, RAX, KIT
7MP:00053868.0RUNX3, LBX1, AQP5, SNAI2, BCL2, RAX
8MP:00053858.0KIT, BCL2, MYB, EFNA1, CYR61, LBX1
9MP:00036317.8RUNX3, PIN1, LBX1, SNAI2, BCL2, RAX
10MP:00053787.7KIT, RUNX3, PIN1, LBX1, AQP5, MYB
11MP:00053847.6RUNX3, PIN1, LBX1, CYR61, MYB, BCL2
12MP:00107687.4RUNX3, LBX1, CYR61, AQP5, MYB, SNAI2

Publications for Adenoid Cystic Carcinoma

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53PubMed
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Articles related to Adenoid Cystic Carcinoma:

(show top 50)    (show all 677)
idTitleAuthorsYear
1
Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma. (24370995)
2013
2
Adenoid cystic carcinoma in the bronchus behaves more aggressively than its tracheal counterpart. (24094522)
2013
3
Adenoid cystic carcinoma of palate: A case report and review of literature. (23946749)
2013
4
High grade transformation in a case of adenoid cystic carcinoma associated with Epstein-Barr virus expression. (24247629)
2013
5
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
6
Analysis of failure in patients with adenoid cystic carcinoma of the head and neck. An international collaborative study. (23784851)
2013
7
Adenoid cystic carcinoma of the upper trachea: a rare neoplasm. (24228208)
2013
8
Adenoid cystic carcinoma of the leg: a case study. (24072374)
2013
9
EMMPRIN contributes to the in vitro invasion of human salivary adenoid cystic carcinoma cells. (22200897)
2012
10
Molecular biology of adenoid cystic carcinoma. (22006498)
2012
11
Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma. (22576684)
2012
12
Adenoid cystic carcinoma of the airway: a 30-year review at one institution. (21907453)
2012
13
Dysphagia due to adenoid cystic carcinoma of the base of the tongue. (22737963)
2012
14
Adenoid cystic carcinoma of the breast diagnosed by fine needle aspiration. (21366736)
2012
15
A primary cutaneous adenoid-cystic carcinoma in a young woman. Differential diagnosis and clinical implications. (21464876)
2011
16
Dedifferentiated adenoid cystic carcinoma of the lacrimal gland. (21283029)
2011
17
Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas. (22096672)
2011
18
Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. (21551254)
2011
19
Immunohistochemical expression of progesterone receptors in pleomorphic adenoma and adenoid cystic carcinoma. (21546738)
2011
20
Prognostic value of quantitative p63 immunostaining in adenoid cystic carcinoma of salivary gland assessed by computerized image analysis. (19877114)
2010
21
Prognostic significance of nuclear survivin expression in resected adenoid cystic carcinoma of the head and neck. (21034499)
2010
22
Adjuvant radiation therapy is associated with improved survival for adenoid cystic carcinoma of the breast. (20589709)
2010
23
Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005. (20447723)
2010
24
Conservative treatment of a rare case of multifocal adenoid cystic carcinoma of the breast: case report and literature review. (20190690)
2010
25
Sialoblastoma in adults: distinction from adenoid cystic carcinoma. (19880331)
2010
26
Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems. (19963131)
2010
27
Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses. (19545368)
2009
28
Metastasectomy for hepatic metastases from adenoid cystic carcinoma of the trachea. (20431735)
2009
29
The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept. (19488017)
2009
30
Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. (19031084)
2009
31
Effects of basic fibroblast growth factor on the proliferation of human salivary adenoid cystic carcinoma cell line ACC-2 and extracellular signal-regulated kinase, Cyclin D1, p2waf/cip1 signaling pathway]. (18605443)
2008
32
Adenoid cystic carcinoma of trachea treated with adjuvant hypofractionated tomotherapy. Case report and literature review. (18468347)
2008
33
The selective expression of CD43 in adenoid cystic carcinoma. (18227725)
2008
34
Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion. (17982624)
2007
35
A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands. (16757202)
2007
36
Cytodiagnosis of adenoid cystic carcinoma of the breast. (17883166)
2007
37
Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation. (18048830)
2007
38
Gene expression profile of salivary adenoid cystic carcinoma associated with perineural invasion. (17592219)
2007
39
Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma. (17431674)
2007
40
Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. (15846389)
2005
41
Tracheobronchial adenoid cystic carcinoma: a clinicopathologic study of 14 cases. (15006985)
2004
42
Differential expression of basement membrane type-IV collagen alpha1, alpha2, alpha5 and alpha6 chains among the histological subtypes of adenoid cystic carcinoma. (15138813)
2004
43
Adenoid cystic carcinoma with hyperostosis after stereotactic radiosurgery. (15287538)
2004
44
Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)
2004
45
Urokinase-type plasminogen activator receptor expression in adenoid cystic carcinoma of the skull base. (12578452)
2003
46
Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. (11978546)
2002
47
A case of adenoid cystic carcinoma (ACC) of the breast and review of the utility of preoperative imaging diagnose. (11180772)
2001
48
Detection of neuroendocrine feature about salivary adenoid cystic carcinoma]. (12539703)
1999
49
Estrogen and progesterone receptors in salivary gland adenoid cystic carcinoma. (8521108)
1995
50
Expressions of oncogene products in adenoid cystic carcinomas of salivary glands: immunohistochemical study]. (1665502)
1991

Variations for Adenoid Cystic Carcinoma

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Expression for genes affiliated with Adenoid Cystic Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Adenoid Cystic Carcinoma.

Pathways for genes affiliated with Adenoid Cystic Carcinoma

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51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9BCL2, KIT
2
Show member pathways
IL2 signaling events mediated by STAT539
9.9BCL2, MYB
3
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)39
9.7KIT, BCL2, SNAI2
49.6KIT, BCL2, MYB
59.6EFNA1, AQP5
69.1KIT, BIRC7, BCL2
79.1EFNA1, MYB, BCL2, KIT

Compounds for genes affiliated with Adenoid Cystic Carcinoma

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1methylcellulose469.9KIT, MYB
2imatinib46 52 1211.7MYB, BCL2, KIT
32-chlorodeoxyadenosine469.6KIT, BCL2
4rapamycin469.4PIN1, MYB, BCL2, KIT
5actinomycin d469.2CYR61, MYB, BCL2, KIT
6paclitaxel46 52 1211.2KIT, BCL2, CYR61, PIN1
75fluorouracil469.1BCL2, BIRC7, KIT
8progesterone46 30 62 25 1213.1KIT, BCL2, MYB, CYR61
9doxorubicin46 52 1211.0KIT, BIRC7, BCL2, MYB
10retinoic acid46 259.9KIT, BCL2, MYB, LBX1, RUNX3
11steroid468.7PIN1, CYR61, MYB, KIT
12estrogen468.7CYR61, AQP5, MYB, SNAI2, BCL2, KIT
13vegf468.4RUNX3, CYR61, EFNA1, MYB, BCL2, KIT
14serine468.2RUNX3, PIN1, MYB, BCL2, BIRC7, KIT
15oligonucleotide467.9KIT, RUNX3, LBX1, CYR61, EFNA1, MYB

GO Terms for genes affiliated with Adenoid Cystic Carcinoma

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17Gene Ontology
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Biological processes related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1lymphoid progenitor cell differentiationGO:00232010.2KIT, BCL2
2negative regulation of anoikisGO:200081110.2BCL2, SNAI2
3pigmentationGO:04347310.1SNAI2, KIT
4melanocyte differentiationGO:03031810.0BCL2, KIT
5hair follicle morphogenesisGO:03106910.0RUNX3, BCL2
6negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0BCL2, SNAI2
7thymus developmentGO:0485389.8MYB, BCL2
8reactive oxygen species metabolic processGO:0725939.7CYR61, BCL2
9ovarian follicle developmentGO:0015419.6BCL2, KIT
10osteoblast differentiationGO:0016499.6SNAI2, CYR61
11positive regulation of cell migrationGO:0303359.5KIT, SNAI2, CYR61
12negative regulation of transcription from RNA polymerase II promoterGO:0001229.2SNAI2, MYB, EFNA1, RUNX3

Products for genes affiliated with Adenoid Cystic Carcinoma

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Sources for Adenoid Cystic Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
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38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
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