MCID: ADN011
MIFTS: 56

Adenoid Cystic Carcinoma malady

Cancer category

Summaries for Adenoid Cystic Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Adenoid cystic carcinoma is a rare form of adenocarcinoma (a cancer that arises from gladular tissue). adenoid cystic carcinoma is found mainly in the head and neck, but can occasionally occur in a woman’s uterus or other sites in the body. it most commonly occurs in the salivary glands, in locations such as the palate (the roof of the mouth), nasopharynx (air passageway at the upper part of the throat and behind the nose), inner lining of the mouth, larynx, or trachea. symptoms may include difficulty swallowing, hoarseness, dull pain, numbness or palpable lumps. regardless of its location, adenoid cystic carcinoma tends to spread along nerves or through the bloodstream. a small percentage of cases spread to the lymph nodes. the most common location for metatasis is the lung. adenoid cystic carcinoma is often unpredictable, with long periods of no activity followed by rapid growth. the cause of adenoid cystic carcinoma is not known and no specific risk factors have been identified. treatment depends on the size and location of the tumor, whether the cancer has spread, and the patient's overall health, but may include surgery, radiation or chemotherapy. last updated: 1/15/2009

MalaCards: Adenoid Cystic Carcinoma, also known as cylindroma, is related to adenocarcinoma and adenoma. An important gene associated with Adenoid Cystic Carcinoma is ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)), and among its related pathways are Apoptosis and Autophagy and C-MYB transcription factor network. The compounds retinoic acid and progesterone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology:8 A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. these structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

Wikipedia:64 Adenoid cystic carcinoma (AdCC) is a rare type of cancer that can exist in many different body sites. It... more...

Aliases & Classifications for Adenoid Cystic Carcinoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

adenoid cystic carcinoma 8 43 10 61
cylindroma 8 43
carcinoma adenoid cystic 45
adenoid cystic cancer 8
adenocystic carcinoma 43
cribriform carcinoma 43
cylindroma nos 8


External Ids:

Disease Ontology8 DOID:4866
NCIt40 C2970
MeSH35 D003528

Related Diseases for Adenoid Cystic Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.3BCL2, SPN, SERPINB5, MMP15, MYB, RUNX3
2adenoma31.1RUNX3, SERPINB5, BCL2, SPN
3squamous cell carcinoma30.9BCL2, SERPINB5, MYB, LBX1, RUNX3, SNAI2
4breast adenoid cystic carcinoma11.0
5lacrimal gland adenoid cystic carcinoma10.9
6trachea adenoid cystic carcinoma10.9
7lung adenoid cystic carcinoma10.9
8trachea carcinoma10.8
9pleomorphic adenoma10.8
10pleomorphic adenoma carcinoma10.8
11pleomorphic carcinoma10.8
12maxillary sinus adenoid cystic carcinoma10.7
13cervical adenoid cystic carcinoma10.7
14laryngeal adenoid cystic carcinoma10.7
15cystic basal cell carcinoma10.7
16adenoid basal cell carcinoma10.7
17basal cell carcinoma10.7
18adenoid squamous cell carcinoma10.6
19mucoepidermoid carcinoma10.6
20myoepithelial carcinoma10.6
21bone carcinoma10.5
22eye carcinoma10.5
23eyelid carcinoma10.5
24prostate adenoid cystic carcinoma10.5
25esophageal adenoid cystic carcinoma10.5
26mucoepidermoid salivary gland carcinoma10.5
27ethmoid sinus adenoid cystic carcinoma10.5
28papillary carcinoma10.5
29small cell carcinoma10.5
30nasopharynx carcinoma10.5
31orbital cyst10.5
32familial cylindromatosis10.5
33basaloid squamous cell carcinoma10.4
34bartholin's gland adenoid cystic carcinoma10.4
35adenoid cystic carcinoma of the corpus uteri10.4
36neuroendocrine carcinoma10.3
37maxillary sinus adenocarcinoma10.3
38spiradenoma10.3
39epithelial-myoepithelial carcinoma10.3
40n syndrome10.3
41thymic carcinoma10.3
42oral squamous cell carcinoma10.3
43hypoxia10.3
44poncet-spiegler's cylindroma10.3
45malignant spiradenoma10.2
46adnexal spiradenoma/cylindroma of a sweat gland10.2
47myoepithelioma10.2
48ankylosing spondylitis10.2
49skene gland carcinoma10.2
50hyperlucent lung10.2

Graphical network of the top 20 diseases related to Adenoid Cystic Carcinoma:



Diseases related to adenoid cystic carcinoma

Clinical Features for Adenoid Cystic Carcinoma

Drugs & Therapeutics for Adenoid Cystic Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Adenoid Cystic Carcinoma

Drug clinical trials:

Search ClinicalTrials for Adenoid Cystic Carcinoma

Search NIH Clinical Center for Adenoid Cystic Carcinoma

Search CenterWatch for Adenoid Cystic Carcinoma

Genetic Tests for Adenoid Cystic Carcinoma

Anatomical Context for Adenoid Cystic Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Adenoid Cystic Carcinoma:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Uterus, Thymus, Smooth muscle, Skeletal muscle, Pancreas, Thyroid, Salivary gland, Breast, Prostate, Testis, Cervix, Tonsil, T cells, B cells, Endothelial, Trachea

Animal Models for Adenoid Cystic Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Adenoid Cystic Carcinoma

Sources:
51PubMed
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Articles related to Adenoid Cystic Carcinoma:

(show top 50)    (show all 701)
idTitleAuthorsYear
1
Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (24265903)
2013
2
Report of two cases of adenoid cystic carcinoma of Bartholin's gland and review of literature. (23548230)
2013
3
Molecular characteristics of homologous salivary adenoid cystic carcinoma cell lines with different lung metastasis ability. (23673996)
2013
4
Signet-ring cell change in adenoid cystic carcinoma: a clinicopathological and immunohistochemical study of four cases. (23379326)
2013
5
Head and neck adenoid cystic carcinoma: what is new in biological markers and treatment? (23222122)
2013
6
19-year oncologic outcomes and the benefit of elective neck dissection in salivary gland adenoid cystic carcinoma. (24170702)
2013
7
Tracheal Adenoid Cystic Carcinoma Treated by Repeated Bronchoscopic Argon Plasma Coagulation as a Palliative Therapy. (23575002)
2013
8
Multiple cutaneous metastases: a rare and late sequelae of lacrimal gland adenoid cystic carcinoma. (23899266)
2013
9
Brain and lung metastasis of Bartholin's gland adenoid cystic carcinoma: a case report. (23945057)
2013
10
MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. (23825564)
2013
11
Treatment outcomes of sinonasal adenoid cystic carcinoma: 30 cases from a single institution. (24080140)
2013
12
EphA2/ephrinA1 mRNA expression and protein production in adenoid cystic carcinoma of salivary gland. (23298804)
2013
13
Nasopharyngeal adenoid cystic carcinoma: magnetic resonance imaging features in ten cases. (22200180)
2012
14
Reappraisal of KIT mutation in adenoid cystic carcinomas of the salivary gland. (22077630)
2012
15
Adenoid cystic carcinoma of the breast in reduction mammoplasty. (23078292)
2012
16
A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. (22179977)
2012
17
Adenoid cystic carcinoma of the esophagus: report of two cases and review of the Chinese literature. (23236991)
2012
18
Revisiting epithelial-to-mesenchymal transition through adenoid cystic carcinoma. (22993306)
2012
19
The T-box transcription factor Brachyury regulates epithelial-mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells. (22931165)
2012
20
Spontaneous regression of recurred adenoid cystic carcinoma in the nasal cavity. (23104530)
2012
21
Dedifferentiated adenoid cystic carcinoma of the lacrimal gland. (21283029)
2011
22
TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma. (21441221)
2011
23
Downregulation of runt-related transcription factor 3 associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland. (21105967)
2011
24
Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland. (21183517)
2011
25
The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. (21618541)
2011
26
Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma. (21894435)
2011
27
Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. (21572406)
2011
28
Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems. (19963131)
2010
29
Erratum to "Ultrastructural assessment of adenoid cystic carcinoma with emphasis on tumour infiltration periphery" [Volume 14, issue 2, 2009, pp. 64-69]. (24376935)
2010
30
Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri--case report. (20432755)
2010
31
Evolution pattern of the Runx3 gene 5'-CpG island methylation in human salivary gland adenoid cystic carcinoma]. (21223798)
2010
32
Adenoid cystic carcinoma of the pterygopalatine fossa presenting as facial pain. (20828499)
2010
33
Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. (19031084)
2009
34
Adenoid cystic carcinoma of the tongue--clinicopathological study and survival analysis. (19480697)
2009
35
Immunotherapy for adenoid cystic carcinoma of salivary glands: cancer/testis antigens and 5-aza-2'-deoxycytidine. (19481355)
2009
36
Adenoid cystic carcinoma of the external auditory canal. (19082366)
2008
37
Primary adenoid cystic carcinoma of the mandible: case report and review of the literature. (19022143)
2008
38
A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands. (16757202)
2007
39
PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. (17669465)
2007
40
Adenoid cystic carcinoma of the Bartholin gland: an overview. (17488169)
2007
41
Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. (17520682)
2007
42
Detection of recurrent adenoid cystic carcinoma with PET-CT. (17581353)
2007
43
Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma. (15959912)
2005
44
Tracheobronchial adenoid cystic carcinoma: a clinicopathologic study of 14 cases. (15006985)
2004
45
Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. (11978546)
2002
46
Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. (11568571)
2001
47
Detection of neuroendocrine feature about salivary adenoid cystic carcinoma]. (12539703)
1999
48
Reduced E-cadherin expression correlates with unfavorable prognosis in adenoid cystic carcinoma of salivary glands of the oral cavity. (9894453)
1999
49
Unusual case of myoepithelioma associated with adenoid cystic carcinoma of the parotid gland. (7677639)
1995
50
Lacrimal gland adenoid cystic carcinoma: intracranial and extracranial en bloc resection. (6269133)
1981

Genetic Variations for Adenoid Cystic Carcinoma

Expression for genes affiliated with Adenoid Cystic Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Adenoid Cystic Carcinoma.

Pathways for genes affiliated with Adenoid Cystic Carcinoma

Sources:
4Cell Signaling Technology, 38NCBI BioSystems Database
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Pathways related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7BCL2, SERPINB5, BIRC7, PIR, TFAP2C
210.6MYB, KIT, BCL2
3
Hide members
10.6BCL2, KIT, SNAI2
410.6BCL2, SERPINB5, SNAI2

Compounds for genes affiliated with Adenoid Cystic Carcinoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB
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Compounds related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1retinoic acid45 2412.0RUNX3, LBX1, TFAP2C, MYB, KIT, SPN
2progesterone45 60 29 11 2414.9MYB, MMP15, KIT, SERPINB5, BCL2
3estrogen4510.8AQP5, TFAP2C
4vegf4510.8BCL2, SERPINB5, KIT, MYB, RUNX3
5doxorubicin45 50 1112.7MYB, BIRC7, KIT, BCL2
6oligonucleotide4510.7BCL2, KIT, MYB, LBX1, RUNX3
7serine4510.6BIRC7, RUNX3
8paraffin4510.4KIT, SERPINB5, SPN, BCL2

GO Terms for genes affiliated with Adenoid Cystic Carcinoma

Sources:
16Gene Ontology
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Cellular components related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.1BCL2, LBX1, TFAP2C, PIR, SNAI2, IMP3

Biological processes related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pigmentationGO:04347310.8EN1, KIT, SNAI2
2male gonad developmentGO:00858410.7BCL2, KIT, TFAP2C
3lymphoid progenitor cell differentiationGO:00232010.7BCL2, KIT
4negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.6BCL2, SNAI2
5response to acidGO:00110110.6ASIC1, BCL2
6camera-type eye morphogenesisGO:04859310.5AQP5, MFN2
7negative regulation of anoikisGO:200081110.3BCL2, SNAI2

Molecular functions related to Adenoid Cystic Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.9AQP5, RUNX3, MFN2, TFAP2C, PIR, MYB
2sequence-specific DNA binding transcription factor activityGO:00370010.8LBX1, TFAP2C, MYB, RAX, PA2G4, EN1

Products for genes affiliated with Adenoid Cystic Carcinoma

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Sources for Adenoid Cystic Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet