MCID: ADN013
MIFTS: 35

Adenoid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Adenoid Squamous Cell Carcinoma

MalaCards integrated aliases for Adenoid Squamous Cell Carcinoma:

Name: Adenoid Squamous Cell Carcinoma 12 14
Adenocarcinoma with Squamous Metaplasia 12 69
Acantholytic Squamous Cell Carcinoma 12 69
Pseudoglandular Squamous Carcinoma 12
Adenoacanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5524
NCIt 47 C4106 C4200

Summaries for Adenoid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

MalaCards based summary : Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia, is related to acantholytic squamous cell skin carcinoma and endometrial adenocarcinoma. An important gene associated with Adenoid Squamous Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Apoptotic cleavage of cellular proteins. The drugs Fentanyl and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and brain.

Related Diseases for Adenoid Squamous Cell Carcinoma

Diseases related to Adenoid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Related Disease Score Top Affiliating Genes
1 acantholytic squamous cell skin carcinoma 11.1
2 endometrial adenocarcinoma 10.8
3 ovary adenocarcinoma 10.8
4 adenoiditis 10.5
5 squamous cell carcinoma 10.5
6 plantar verrucous skin carcinoma 10.4 CDH1 VIM
7 cellular ependymoma 10.4 CDH1 VIM
8 secondary syphilis 10.4 CDH1 VIM
9 kidney benign neoplasm 10.4 CDH1 VIM
10 space motion sickness 10.4 KRT20 VIM
11 ovarian mucinous adenocarcinoma 10.4 KRT20 VIM
12 mesenchymoma 10.4 KRT20 VIM
13 myoepithelial carcinoma 10.4 KRT20 VIM
14 angioma serpiginosum 10.3 CDH1 KRT20
15 follicular basal cell carcinoma 10.3 CDH1 KRT20
16 gorlin bushkell jensen syndrome 10.3 CDH1 KRT20
17 childhood teratoma of the ovary 10.3 CDH1 KRT20
18 dense deposit disease 10.3 KRT20 VIM
19 chondroblastoma 10.3 KRT20 VIM
20 cystic basal cell carcinoma 10.3 CDH1 KRT20
21 linitis plastica 10.3 CDH1 VIM
22 cribriform carcinoma 10.3 CDH1 KRT20
23 microcystic meningioma 10.3 KRT20 VIM
24 alcohol-induced mental disorder 10.3 HBA1 VIM
25 testicular trophoblastic tumor 10.3 KRT20 MUC6
26 avian influenza 10.3 CDH1 KRT20
27 tabes dorsalis 10.3 KRT20 MUC6
28 uterine corpus adenofibroma 10.3 KRT20 MUC6
29 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.2 CDH1 MUC6
30 migraine with aura 10.2 KRT20 MUC6
31 childhood ovarian endodermal sinus tumor 10.2 KRT20 MUC6
32 mucin-rich endometrial endometrioid adenocarcinoma 10.2 HBA1 VIM
33 cavernous sinus thrombosis 10.2 KRT20 MUC6
34 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 10.2 HBA1 VIM
35 pacinian tumor 10.2 KRT20 MUC6
36 ossifying fibromyxoid tumor 10.2 HBA1 VIM
37 mediastinal osteogenic sarcoma 10.2 HBA1 VIM
38 spermatogenic failure 13 10.2 CDH1 VIM
39 hereditary spastic paraplegia 62 10.2 CDH1 HBA1
40 optic papillitis 10.2 KRT20 MUC6
41 fallopian tube leiomyosarcoma 10.2 CDH1 MUC6
42 periventricular nodular heterotopia 6 10.2 CDH1 VIM
43 pericardial tuberculosis 10.2 HBA1 VIM
44 choriocarcinoma 10.2 KRT20 MUC6
45 prostate transitional cell carcinoma 10.2 CDH1 KRT20
46 hyperpituitarism 10.2 HBA1 VIM
47 struma ovarii 10.2 KRT20 MUC6
48 urethra adenocarcinoma 10.2 CDH1 KRT20
49 ectodermal dysplasia with natal teeth, turnpenny type 10.1 CDH1 KRT20
50 arteritic anterior ischemic optic neuropathy 10.1 CDH1 KRT20

Graphical network of the top 20 diseases related to Adenoid Squamous Cell Carcinoma:



Diseases related to Adenoid Squamous Cell Carcinoma

Symptoms & Phenotypes for Adenoid Squamous Cell Carcinoma

Drugs & Therapeutics for Adenoid Squamous Cell Carcinoma

Drugs for Adenoid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Fluconazole Approved Phase 2, Phase 3 86386-73-4 3365
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 22916-47-8 4189
4
Cevimeline Approved Phase 3 107233-08-9 83898 25137844
5
Doxepin Approved Phase 3 1668-19-5 667477 667468
6
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
7
Megestrol acetate Approved, Vet_approved Phase 3 595-33-5 11683
8 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
9
Docetaxel Approved May 1996, Investigational Phase 3,Phase 1,Phase 2 114977-28-5 148124 9877265
10 Alkylating Agents Phase 3,Phase 2
11 Liver Extracts Phase 3,Phase 2,Phase 1
12 Anti-Infective Agents Phase 2, Phase 3,Phase 1
13 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
14 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
15 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
16 Mitomycins Phase 3
17 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 1,Phase 2
18 Porfiromycin Phase 3
19 Adjuvants, Anesthesia Phase 3
20 Analgesics Phase 3
21 Analgesics, Opioid Phase 3
22 Anesthetics Phase 3
23 Anesthetics, General Phase 3
24 Anesthetics, Intravenous Phase 3
25 Central Nervous System Depressants Phase 3
26 Narcotics Phase 3
27 Peripheral Nervous System Agents Phase 3
28 Antifungal Agents Phase 2, Phase 3,Phase 1
29 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
30 Hormone Antagonists Phase 2, Phase 3
31 Hormones Phase 2, Phase 3,Phase 1
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
33 Steroid Synthesis Inhibitors Phase 2, Phase 3
34 Autonomic Agents Phase 3
35 Cholinergic Agents Phase 3
36 Neurotransmitter Agents Phase 3
37 Antidepressive Agents Phase 3
38 Antidepressive Agents, Tricyclic Phase 3
39 Histamine Antagonists Phase 3
40
Histamine Phosphate Phase 3 51-74-1 65513
41 Psychotropic Drugs Phase 3
42 Antineoplastic Agents, Hormonal Phase 3
43 Appetite Stimulants Phase 3
44 Central Nervous System Stimulants Phase 3
45 Contraceptive Agents Phase 3
46 Contraceptives, Oral Phase 3
47
Megestrol Phase 3 3562-63-8 19090 3080587
48 Antimitotic Agents Phase 3,Phase 2,Phase 1
49 Cola Nutraceutical Phase 3,Phase 2,Phase 1
50
Indinavir Approved Phase 2 150378-17-9 5362440

Interventional clinical trials:

(show top 50) (show all 72)

id Name Status NCT ID Phase Drugs
1 Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer Completed NCT00002507 Phase 3 mitomycin C;porfiromycin
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer Completed NCT00090337 Phase 3
4 Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed NCT00002533 Phase 2, Phase 3 fluconazole
5 Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer Completed NCT00017511 Phase 3 cevimeline hydrochloride
6 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Completed NCT01156142 Phase 3 doxepin hydrochloride
7 Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract Completed NCT00765440 Phase 3
8 Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer Completed NCT00006799 Phase 3 megestrol acetate
9 Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery Withdrawn NCT00041171 Phase 3 Hypericum perforatum;docetaxel
10 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
11 Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer Completed NCT00101348 Phase 1, Phase 2 erlotinib hydrochloride
12 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
13 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine
14 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
15 Oxaliplatin and Capecitabine in Treating Patients With Relapsed or Metastatic Head and Neck Cancer Completed NCT00448552 Phase 2 capecitabine;oxaliplatin
16 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2 docetaxel
17 Docetaxel in Treating Patients With Solid Tumors Completed NCT00003565 Phase 2 docetaxel
18 Epirubicin, Carboplatin, and Capecitabine in Treating Patients With Unresectable Locally Advanced, Metastatic, or Recurrent Solid Tumor Completed NCT00021047 Phase 1, Phase 2 capecitabine;carboplatin;epirubicin hydrochloride
19 Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors Completed NCT00019331 Phase 2 DetoxPC
20 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer Completed NCT00004901 Phase 1, Phase 2 ethynyluracil;fluorouracil;hydroxyurea
21 Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer Completed NCT00021333 Phase 2 cisplatin;paclitaxel
22 Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer Completed NCT00509665 Phase 2 doxorubicin hydrochloride;gemcitabine hydrochloride
23 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
24 18F FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy Recruiting NCT01806675 Phase 1, Phase 2 fludeoxyglucose F 18;2-fluoropropionyl-labeled pegylated dimeric RGD peptide
25 A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages Recruiting NCT03274414 Phase 2 Cisplatin
26 Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors Active, not recruiting NCT00859937 Phase 2 dasatinib
27 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2
28 MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer Unknown status NCT00984074 Phase 1
29 Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00023959 Phase 1 hydroxyurea;fluorouracil
30 Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors Completed NCT00089362 Phase 1 alvespimycin hydrochloride
31 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
32 Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer Completed NCT01637194 Phase 1 everolimus
33 Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer Completed NCT00397384 Phase 1 cetuximab;erlotinib hydrochloride
34 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
35 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
36 Head & Neck Cancer Survivorship: Physical and Functional Status Completed NCT00751816 Phase 1 systemic chemotherapy
37 Chemotherapy in Treating Patients With Refractory Advanced Solid Tumors or Hematologic Cancer Completed NCT00004065 Phase 1 tanespimycin
38 Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors Completed NCT00010023 Phase 1 capecitabine;cisplatin
39 Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors Completed NCT00006036 Phase 1 cisplatin;lurtotecan liposome
40 Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer Completed NCT00045006 Phase 1 vorinostat
41 Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function Completed NCT00002901 Phase 1 docetaxel
42 SU5416 and Paclitaxel in Treating Patients With Recurrent, Locally Advanced or Metastatic Cancer of the Head and Neck Completed NCT00005647 Phase 1 paclitaxel;semaxanib
43 Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors Completed NCT00014456 Phase 1 docetaxel;gemcitabine hydrochloride
44 NGR-TNF in Treating Patients With Advanced Solid Tumors Completed NCT00098943 Phase 1
45 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
46 Vaccine Therapy in Treating Patients With Advanced or Recurrent Cancer Completed NCT00019110 Phase 1
47 Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC Recruiting NCT03291002 Phase 1
48 Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer Active, not recruiting NCT00470496 Phase 1 HPPH;photodynamic therapy
49 Stereotactic Radiosurgery in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer Active, not recruiting NCT00851253 Phase 1
50 Photodynamic Therapy in Treating Patients With Skin Cancer or Solid Tumors Metastatic to the Skin Terminated NCT00023790 Phase 1 silicon phthalocyanine 4

Search NIH Clinical Center for Adenoid Squamous Cell Carcinoma

Genetic Tests for Adenoid Squamous Cell Carcinoma

Anatomical Context for Adenoid Squamous Cell Carcinoma

MalaCards organs/tissues related to Adenoid Squamous Cell Carcinoma:

39
Lung, Skin, Brain, Liver, Breast, Salivary Gland, Kidney

Publications for Adenoid Squamous Cell Carcinoma

Articles related to Adenoid Squamous Cell Carcinoma:

(show all 29)
id Title Authors Year
1
Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma. ( 22923907 )
2012
2
Adenoid squamous cell carcinoma of the oral cavity. ( 22808297 )
2012
3
Primary adenoid squamous cell carcinoma of the oral cavity. ( 16445819 )
2006
4
Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. ( 17071808 )
2006
5
Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. ( 16856971 )
2006
6
A case of adenoid squamous cell carcinoma of the breast skin. ( 11341233 )
2000
7
A Case of Adenoid Squamous Cell Carcinoma of the Breast Skin. ( 11091718 )
1999
8
Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung. ( 10495320 )
1999
9
Primary adenoid squamous cell carcinoma of the upper lip associated with a locoregional metastasis: a case report and review of the literature. ( 10319839 )
1999
10
A case of pseudovascular adenoid squamous cell carcinoma of the skin with spindle cell pattern. ( 9350106 )
1997
11
Mucosal adenoid squamous cell carcinoma of the head and neck. ( 8651637 )
1996
12
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. ( 8163270 )
1994
13
Oral adenoid squamous cell carcinoma: a report of three cases and review of the literature. ( 8492207 )
1993
14
Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. ( 1599022 )
1992
15
Adenoid Squamous Cell Carcinoma. ( 28134144 )
1988
16
Adenoid squamous cell carcinoma of the nasopharynx and neck region. ( 3518653 )
1986
17
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. ( 3825538 )
1986
18
A clinicopathologic study of 21 cases of adenoid squamous cell carcinoma of the eyelid and periorbital region. ( 3976805 )
1985
19
Adenoid squamous cell carcinoma of the penis. Report of a surgical case clinically manifested with rapid lung metastasis. ( 6670557 )
1983
20
Adenosquamous carcinoma of skin appendages (adenoid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, adenocanthoma of sweat gland of Lever) of the vulva: a clinical and ultrastructural study. ( 709534 )
1978
21
Adenoid squamous cell carcinoma of the oral cavity: report of the first case arising in the tongue. ( 880122 )
1977
22
Adenoid squamous cell carcinoma of the oral mucosa: report of two autopsy cases. ( 922664 )
1977
23
Adenoid squamous cell carcinoma of the vulva. ( 4810097 )
1974
24
Adenoid squamous-cell carcinoma of vermilion mucosa of lower lip. ( 4521951 )
1974
25
Adenoid squamous cell carcinoma of the lip: report of cases. ( 4504554 )
1972
26
Adenoid squamous-cell carcinoma (adenocanthoma) of the oral labial mucosa. A clinicopathologic study of fifteen cases. ( 5285191 )
1971
27
Multiple adenoid squamous cell carcinoma. ( 5093173 )
1971
28
Adenoid squamous cell carcinoma (adenoacanthoma). A clinicopathologic study of 155 patients. ( 5927198 )
1966
29
ADENOID SQUAMOUS CELL CARCINOMA (ADENOACANTHOMA OF LEVER). REPORT OF SEVEN CASES AND REVIEW. ( 14107628 )
1964

Variations for Adenoid Squamous Cell Carcinoma

Expression for Adenoid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Adenoid Squamous Cell Carcinoma.

Pathways for Adenoid Squamous Cell Carcinoma

Pathways related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 CDH1 KRT20 VIM
2
Show member pathways
11.22 CDH1 VIM
3 9.88 CDH1 VIM

GO Terms for Adenoid Squamous Cell Carcinoma

Biological processes related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 8.62 KRT20 VIM

Molecular functions related to Adenoid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 KRT20 VIM

Sources for Adenoid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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