Aliases & Classifications for Adenoiditis

MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis 12 14 69
Chronic Adenoiditis 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050145
ICD10 32 J35.02
ICD9CM 34 474.01
SNOMED-CT 64 195794009 232420002

Summaries for Adenoiditis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to adenoid hypertrophy and salivary gland adenoid cystic carcinoma, and has symptoms including pain, redness and swelling. An important gene associated with Adenoiditis is FCN2 (Ficolin 2). The drugs Dexmedetomidine and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is... more...

Related Diseases for Adenoiditis

Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 adenoid hypertrophy 12.5
2 salivary gland adenoid cystic carcinoma 12.4
3 cervical adenoid cystic carcinoma 12.1
4 trachea adenoid cystic carcinoma 12.0
5 lung adenoid cystic carcinoma 12.0
6 maxillary sinus adenoid cystic carcinoma 12.0
7 prostate adenoid cystic carcinoma 12.0
8 lacrimal gland adenoid cystic carcinoma 12.0
9 adenoid basal cell carcinoma 12.0
10 breast adenoid cystic carcinoma 12.0
11 esophageal adenoid cystic carcinoma 12.0
12 laryngeal adenoid cystic carcinoma 12.0
13 bartholin's gland adenoid cystic carcinoma 12.0
14 adenoid squamous cell carcinoma 12.0
15 parotid gland adenoid cystic carcinoma 12.0
16 ethmoid sinus adenoid cystic carcinoma 11.9
17 adenoid basal carcinoma of the cervix uteri 11.9
18 lymph node adenoid cystic carcinoma 11.8
19 cervical adenoid basal carcinoma 11.8
20 adenoid cystic carcinoma of the corpus uteri 11.8
21 sublingual gland adenoid cystic carcinoma 11.8
22 trichoepithelioma, multiple familial, 1 11.7
23 tonsillitis 11.7
24 multiple familial trichoepithelioma 11.5
25 cutaneous adenocystic carcinoma 11.4
26 sleep apnea 11.2
27 paranasal sinus cancer 11.1
28 prostate cancer 10.9
29 prostate cancer, hereditary, 1 10.9
30 prostate cancer, hereditary, 12 10.9
31 prostate cancer, hereditary, 13 10.9
32 prostate cancer, hereditary, 11 10.9
33 prostate cancer, hereditary, 2 10.9
34 plague 10.9
35 calcifying epithelial odontogenic tumor 10.9
36 squamous cell carcinoma 10.4
37 adenocarcinoma 10.3
38 otitis media 10.3
39 adenoma 10.2
40 polymorphous low-grade adenocarcinoma 10.2
41 pleomorphic adenoma 10.2
42 basal cell carcinoma 1 10.2
43 basal cell carcinoma 10.2
44 chronic conjunctivitis 10.1
45 mucoepidermoid carcinoma 10.1
46 nasopharyngitis 10.1
47 rhinitis 10.1
48 allergic rhinitis 10.0
49 endotheliitis 10.0
50 sinusitis 10.0

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to Adenoiditis

Symptoms & Phenotypes for Adenoiditis

Symptoms:

12
  • pain
  • redness
  • swelling
  • difficulty swallowing

GenomeRNAi Phenotypes related to Adenoiditis according to GeneCards Suite gene sharing:

25 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.68 LY75
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.68 TYROBP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.68 LY75
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.68 LY75
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.68 CARD9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.68 LY75 TYROBP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 CARD9
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.68 LY75
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 LY75
10 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.68 CARD9
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.68 CARD9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.68 TYROBP CARD9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.68 CARD9
14 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.68 CARD9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.68 TYROBP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.68 LY75
17 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.68 LY75
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.35 CARD9
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.35 CARD9
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.35 CNOT4 CARD9
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.35 CNOT4

Drugs & Therapeutics for Adenoiditis

Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
2 Analgesics Phase 4
3 Central Nervous System Depressants Phase 4
4 Adrenergic Agents Phase 4
5 Adrenergic Agonists Phase 4
6 Adrenergic alpha-2 Receptor Agonists Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Neurotransmitter Agents Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Peripheral Nervous System Agents Phase 4
11 Hypnotics and Sedatives Phase 4
12 Pharmaceutical Solutions Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine

Search NIH Clinical Center for Adenoiditis

Genetic Tests for Adenoiditis

Anatomical Context for Adenoiditis

MalaCards organs/tissues related to Adenoiditis:

38
Salivary Gland, Breast, Lung, Tonsil, Trachea, Skin, Tongue

Publications for Adenoiditis

Articles related to Adenoiditis:

(show top 50) (show all 1055)
# Title Authors Year
1
Evaluation of choroidal thickness in children with adenoid hypertrophy. ( 29313145 )
2018
2
In reply to "Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease", by Zhengcai Lou. ( 29423745 )
2018
3
Discordant correlation of breast adenoid cystic carcinoma on imaging and pathology: A case report and literature review on surgical management. ( 29268125 )
2018
4
Reply to the letter to the author concerning: 'Does adenoid hypertrophy affect disease severity in children with allergic rhinitis?' ( 29423746 )
2018
5
Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma. ( 29277772 )
2018
6
Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis. ( 29399171 )
2018
7
MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma. ( 28594149 )
2017
8
Halitosis in children with adenoid hypertrophy. ( 29146888 )
2017
9
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. ( 28236426 )
2017
10
Adenoid hypertrophy in children and allergic rhinitis. ( 28887688 )
2017
11
Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population. ( 28823693 )
2017
12
Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma. ( 29259386 )
2017
13
c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas. ( 27974718 )
2017
14
Garcin syndrome caused by parotid gland adenoid cystic carcinoma: A case report. ( 29137049 )
2017
15
HIF1I+ in Tumorigenesis of Adenoid Cystic Carcinoma. ( 28179306 )
2017
16
Adenoids in paediatric chronic rhinosinusitis, deep neck space infections and optimising otowicks in otitis externa. ( 28841132 )
2017
17
Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )
2017
18
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy. ( 28231295 )
2017
19
The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA. ( 29266837 )
2017
20
Adenoid ameloblastoma with dentinoid: A rare hybrid variant. ( 28932051 )
2017
21
Adenoid cystic carcinoma of the lacrimal gland is frequently characterized by MYB rearrangement. ( 28085142 )
2017
22
Correction: Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. ( 28642227 )
2017
23
Correlation and reliability of cone-beam computed tomography nasopharyngeal volumetric and area measurements as determined by commercial software against nasopharyngoscopy-supported diagnosis of adenoid hypertrophy. ( 28651774 )
2017
24
Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. ( 28098165 )
2017
25
Mithramycin inhibits epithelial-to-mesenchymal transition and invasion by downregulating SP1 and SNAI1 in salivary adenoid cystic carcinoma. ( 28631560 )
2017
26
Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study. ( 28151884 )
2017
27
Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis. ( 28600602 )
2017
28
Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography. ( 28382475 )
2017
29
Association between high expression of phosphorylated Akt and mammalian target of rapamycin and improved survival in salivary gland adenoid cystic carcinoma. ( 28230926 )
2017
30
Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors. ( 27870570 )
2017
31
Adenoid ameloblastoma with dentinoid and cellular atypia: a case report and literature review. ( 29449727 )
2017
32
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma. ( 27898620 )
2017
33
Breast Adenoid Cystic Carcinoma: A Rare Case Report and Review of the Literature. ( 28798006 )
2017
34
Pre- and post-operative application of acoustic rhinometry in children with otitis media with effusion and with or without adenoid hypertrophy-a retrospective analysis. ( 29224765 )
2017
35
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. ( 28498281 )
2017
36
Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma. ( 28152077 )
2017
37
Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. ( 28228352 )
2017
38
Clinicopathological characteristics of KIT and protein kinase C-I' expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour. ( 28561935 )
2017
39
Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells. ( 28277192 )
2017
40
Prevalence of adenoid hypertrophy: A systematic review and meta-analysis. ( 29153763 )
2017
41
"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? ( 28474190 )
2017
42
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma. ( 28820917 )
2017
43
Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population. ( 28263490 )
2017
44
Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. ( 28914715 )
2017
45
Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma. ( 28168897 )
2017
46
B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway. ( 28386362 )
2017
47
Neoadjuvant chemoradiotherapy followed by radical vulvectomy for adenoid cystic carcinoma of Bartholin's gland: a case report and review of the literature. ( 27048121 )
2016
48
Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis. ( 27144125 )
2016
49
EphA2 silencing promotes growth, migration, and metastasis in salivary adenoid cystic carcinoma: in vitro and in vivo study. ( 27186278 )
2016
50
Twist Expression in Pleomorphic Adenoma, Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma of Salivary Glands. ( 26832177 )
2016

Variations for Adenoiditis

Expression for Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for Adenoiditis

GO Terms for Adenoiditis

Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 8.96 CARD9 FCN2
2 innate immune response GO:0045087 8.8 CARD9 FCN2 TYROBP

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.62 FCN2 LY75

Sources for Adenoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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