MCID: ADN002
MIFTS: 60

Adenoiditis malady

Summaries for Adenoiditis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. it occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. the infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards: Adenoiditis, also known as chronic adenoiditis, is related to adenoid cystic carcinoma and squamous cell carcinoma, and has symptoms including difficulty swallowing, swelling and redness. An important gene associated with Adenoiditis is MUC1 (mucin 1, cell surface associated), and among its related pathways are MicroRNAs in cancer and Cytoskeleton remodeling Keratin filaments. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related mouse phenotypes are cellular and normal.

Wikipedia:63 Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is... more...

Aliases & Classifications for Adenoiditis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

adenoiditis 8 10 60
chronic adenoiditis 8 60


External Ids:

Disease Ontology8 DOID:0050145
ICD9CM27 474.01

Related Diseases for Adenoiditis

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17GeneCards, 18GeneDecks
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Diseases related to Adenoiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 286)
idRelated DiseaseScoreTop Affiliating Genes
1adenoid cystic carcinoma31.8CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
2squamous cell carcinoma30.9CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
3adenocarcinoma30.8CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
4basal cell carcinoma30.7LGALS3, ACTC1, KRT20, KRT7
5adenoma30.6CEACAM3, SERPINB5, LGALS3, ACTC1, KRT20, KRT7
6pleomorphic adenoma30.5SERPINB5, ACTC1, KRT14, MUC1, S100A1, S100B
7mucoepidermoid carcinoma30.5ACTC1, KRT7, KRT14, MUC1, S100A1
8papillary carcinoma30.1CEACAM3, SERPINB5, LGALS3, ERBB3, ACTC1, KRT20
9melanoma30.1CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
10angiosarcoma30.0SERPINA3, ACTC1, KRT14, MUC1, VIM
11spiradenoma30.0CYLD
12lung adenocarcinoma29.9CEACAM3, ERBB3, KRT20, KRT7, RASSF1, MUC1
13syringoma29.9CEACAM3, KRT14, MUC1, S100A1, S100B
14neuroendocrine carcinoma29.9KRT20, KRT7, KIT, MUC1, S100B
15transitional cell carcinoma29.9CEACAM3, ERBB3, KRT20, KRT7, KRT14
16papilloma29.9ACTC1, KRT20, KRT14, RASSF1
17spindle cell carcinoma29.9ACTC1, MUC1, VIM
18adenosquamous carcinoma29.9KRT20, KRT7, MUC1
19epithelial-myoepithelial carcinoma29.9KRT14
20breast cancer29.7CEACAM3, SERPINB5, LGALS3, ERBB3, KRT7, KRT14
21sarcoma29.7SERPINB5, ERBB3, ACTC1, KIT, MUC1, S100A1
22lung small cell carcinoma29.7CEACAM3, KRT20, KRT7, KRT14, RASSF1, KIT
23myoepithelioma29.7SERPINB5, ACTC1, KRT14, S100A1, S100B, VIM
24meningioma29.7MUC1, S100A1, S100B, VIM
25rhabdomyosarcoma29.7ERBB3, ACTC1, S100A1, S100B, VIM
26leukemia29.7SERPINA3, KRT14, KIT
27papillary thyroid carcinoma29.7LGALS3, RASSF1, S100A1
28large cell carcinoma29.7CEACAM3, KRT20, KRT7
29neurofibromatosis29.7KRT14, KIT, S100B
30craniopharyngioma29.7KRT14
31brooke-spiegler syndrome29.7CYLD
32inverted papilloma29.7KRT20
33pneumonia29.7MUC1
34cholesteatoma29.7LGALS3, KRT14, S100A1
35adenoid squamous cell carcinoma10.6
36breast adenoid cystic carcinoma10.6
37lacrimal gland adenoid cystic carcinoma10.6
38adenoid basal cell carcinoma10.5
39lung adenoid cystic carcinoma10.5
40tonsillitis10.5
41trachea adenoid cystic carcinoma10.5
42otitis media10.5
43pleomorphic adenoma carcinoma10.4
44cystic basal cell carcinoma10.4
45pleomorphic carcinoma10.4
46maxillary sinus adenoid cystic carcinoma10.3
47bartholin's gland adenoid cystic carcinoma10.3
48cervical adenoid cystic carcinoma10.3
49laryngeal adenoid cystic carcinoma10.3
50prostate adenoid cystic carcinoma10.3

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to adenoiditis

Clinical Features for Adenoiditis

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8Disease Ontology
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Symptoms:

8
  • difficulty swallowing
  • swelling
  • redness
  • pain

Drugs & Therapeutics for Adenoiditis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenoiditis

Drug clinical trials:

Search ClinicalTrials for Adenoiditis

Search NIH Clinical Center for Adenoiditis

Search CenterWatch for Adenoiditis

Genetic Tests for Adenoiditis

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Anatomical Context for Adenoiditis

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32MalaCards
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MalaCards organs/tissues related to Adenoiditis:

32
Salivary gland, Breast, Lung, Tonsil, Trachea, Skin, Tongue, Cervix, Endothelial, Liver, Bone, Prostate, Lymph node, Thyroid, Kidney, Smooth muscle, T cells, B cells, Testis, Nk cells, Testes, Pancreas, Bone marrow, Thymus, Brain, Spinal cord, Heart, Skeletal muscle

Animal Models for Adenoiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenoiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.6SERPINB5, VIM, SOX4, NID1, PIN1, CYLD
2MP:000287311.3S100B, S100A1, SOX4, MUC1, CYLD, KIT
3MP:000538511.2VIM, S100A1, SOX4, NID1, KIT, RASSF1
4MP:001077111.0S100B, SOX4, PIN1, KRT14, ERBB3
5MP:000538111.0SOX4, MUC1, CYLD, KIT, KRT14, ERBB3
6MP:000539110.9VIM, SOX4, NID1, PIN1, MUC1, KIT
7MP:000538810.8CYLD, KRT14, ERBB3, LGALS3
8MP:000537610.8ACTC1, KRT14, CYLD, SOX4
9MP:000200610.6MUC1, CYLD, KIT, RASSF1, KRT14, ERBB3

Publications for Adenoiditis

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50PubMed
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Articles related to Adenoiditis:

(show top 50)    (show all 843)
idTitleAuthorsYear
1
High grade transformation in a case of adenoid cystic carcinoma associated with Epstein-Barr virus expression. (24247629)
2013
2
Adenoid cystic carcinoma on the dorsum of the tongue. (23798839)
2013
3
Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming. (23778135)
2013
4
Antitumor effect of human TRAIL on adenoid cystic carcinoma using magnetic nanoparticle-mediated gene expression. (22633896)
2013
5
Adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study. (23691446)
2013
6
Cetuximab and platinum-based chemoradio- or chemotherapy of patients with epidermal growth factor receptor expressing adenoid cystic carcinoma: a phase II trial. (23942070)
2013
7
Adenoid cystic carcinoma of the nasopharynx: a case report and a discussion about prognostic factors and the role of local treatments. (23748830)
2013
8
Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker. (23611357)
2013
9
MicroRNA profiling of salivary adenoid cystic carcinoma: association of miR-17-92 upregulation with poor outcome. (23825564)
2013
10
EphA2/ephrinA1 mRNA expression and protein production in adenoid cystic carcinoma of salivary gland. (23298804)
2013
11
Molecular biology of adenoid cystic carcinoma. (22006498)
2012
12
Adenoid cystic carcinoma of the breast: case report and review of literature. (22613278)
2012
13
Differential expression of Immunoglobulin A in the adenoids of children with and without exudative otitis media. (22425064)
2012
14
Developmental transcription factor EN1--a novel biomarker in human salivary gland adenoid cystic carcinoma. (21800291)
2012
15
Adenoid cystic carcinoma of the buccal mucosa: A case report and review of the literature. (23559934)
2012
16
TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma. (21441221)
2011
17
Adenoid cystic carcinoma of the prostate: case report on a rare entity and review of the literature. (21440997)
2011
18
Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland. (21183517)
2011
19
CDH12 promotes the invasion of salivary adenoid cystic carcinoma. (21573496)
2011
20
Expression and significance of Cyr61 in distant metastasis cells of human primary salivary adenoid cystic carcinoma. (21601497)
2011
21
Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-I_B pathways through a crossed phosphatidylinositol 3-kinase/Akt/II_B kinase complex signaling axis in adenoid cystic carcinoma. (20959361)
2011
22
Effect of ERK inhibitor on pulmonary metastasis of inoculated human adenoid cystic carcinoma cells in nude mice. (20123382)
2010
23
ALDH high adenoid cystic carcinoma cells display cancer stem cell properties and are responsible for mediating metastasis. (20450887)
2010
24
Adenoid cystic carcinoma of the pterygopalatine fossa presenting as facial pain. (20828499)
2010
25
Conservative treatment of adenoid cystic carcinoma with plaque radiotherapy: a case report. (20305520)
2010
26
Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma. (18844240)
2009
27
Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. (19557180)
2009
28
Management of extra sellar craniopharyngioma masquerading as hypertrophied adenoid tissue in a 6-year-old boy. (18620758)
2008
29
Primary tracheal adenoid cystic carcinoma with malignant pleural effusion. (18310988)
2008
30
Mucin gene expression in hypertrophic adenoids. (17851936)
2007
31
Suppression of salivary adenoid cystic carcinoma growth and metastasis by ErbB3 binding protein Ebp1 gene transfer. (17266032)
2007
32
Clinical analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. (16386975)
2006
33
Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. (15846389)
2005
34
p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. (15529180)
2005
35
Immunohistochemical evaluation of p27 (kip1) in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. (16436005)
2005
36
P53, bcl-2 and Ki-67 expression in adenoid cystic carcinoma of the palate. A clinico-pathologic study of 21 cases with long-term follow-up. (15792122)
2005
37
Expression of the urokinase receptor regulates focal adhesion assembly and cell migration in adenoid cystic carcinoma cells. (15521066)
2005
38
High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid. (12149489)
2002
39
Cyclooxygenase-2 expression in an adenoid cystic carcinoma of the uterine cervix. (11496309)
2001
40
Atypical plexiform ameloblastoma with dentinoid: adenoid ameloblastoma with dentinoid. (11302246)
2001
41
Cervical adenoid cystic carcinoma coexisting with multiple human papillomavirus-associated genital lesions. A common etiology? (10352392)
1999
42
Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. (9635682)
1998
43
A case of uterine cervical adenoid cystic carcinoma: immunohistochemical study for basement membrane material. (7724157)
1995
44
Pseudovascular adenoid squamous cell carcinoma of the lung: clinicopathologic study of three cases and comparison with true pleuropulmonary angiosarcoma. (8163270)
1994
45
Primary adenoid cystic carcinoma masquerading as syringoma of the scalp. (2158756)
1990
46
Neck dissection for laryngeal adenoid cystic carcinoma: is it indicated? (2158263)
1990
47
Adenoid squamous cell carcinoma of the skin overlying the right breast. An autopsy case clinically manifested with rapid growth and widely spreading metastases. (3825538)
1986
48
Adenoid hypertrophy, cyanosis and cor pulmonale, in children with congenital heart disease. (4686672)
1973
49
Cor pulmonale due to hypertrophic tonsils and adenoids causing cardiac arrhythmias. (4256125)
1971
50
Syringocystadenoma papilliferum, nevus sebaceus and basal-cell epithelioma (with features of epithelioma adenoides cysticum and syringoma); their concurrent presence in a single tumor; report of a case. (14901605)
1951

Genetic Variations for Adenoiditis

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Expression for genes affiliated with Adenoiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for genes affiliated with Adenoiditis

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29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Adenoiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8SERPINB5, ERBB3, RASSF1, SOX4, VIM
210.7VIM, KRT14, KRT7
310.6LGALS3, S100B

Compounds for genes affiliated with Adenoiditis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Adenoiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.0S100B, S100A1, SOX4, MUC1, KIT, KRT14
2paraffin4411.9KRT20, ACTC1, ERBB3, LGALS3, SERPINA3, SERPINB5
3calcium44 49 11 2414.7S100A1, LGALS3, ACTC1, KRT14, KIT, MUC1
4hematoxylin4411.7S100A1, MUC1, CEACAM3, S100B, VIM, KIT
5vegf4411.7MUC1, VIM, KIT, S100B, KRT7, KRT20
6retinoic acid44 2412.7S100B, LGALS3, ACTC1, KRT7, KRT14, VIM
7tyrosine4411.7ACTC1, S100A1, MUC1, KIT, KRT14, KRT7
8alanine4411.6ERBB3, SERPINA3, LGALS3, VIM, S100B, PIN1
9mucicarmine4411.6ACTC1, KRT20, KRT7, KRT14, MUC1, S100A1
10testosterone44 59 11 2414.5ACTC1, KRT20, KRT7, KIT, MUC1, VIM
11threonine4411.5KRT14, ERBB3, LGALS3, S100B, RASSF1, KIT
12formaldehyde44 2412.5ACTC1, KRT20, KRT7, LGALS3, S100B, KIT
13b 7234411.5CEACAM3, ACTC1, KRT20, KRT7, S100A1, MUC1
14lipid4411.5MUC1, VIM, SERPINB5, SERPINA3, LGALS3, ERBB3
15iron44 2412.5S100B, S100A1, KRT14, VIM, KRT20, ACTC1
16cysteine4411.4MUC1, SERPINA3, KRT14, KIT, VIM, S100B
17matrigel4411.4ACTC1, KRT7, VIM, NID1, MUC1, SERPINB5
18glucose4411.4KRT14, SERPINA3, KRT7, MUC1, ACTC1, CEACAM3
19aspartate4411.4PIN1, CEACAM3, ACCS, NID1, S100B, VIM
20oligonucleotide4411.3VIM, SERPINA3, LGALS3, ERBB3, KIT, SOX4
21methotrexate44 49 1113.3SERPINA3, VIM, MUC1, KIT, KRT7, CEACAM3
22nitric oxide44 11 2413.3CEACAM3, SERPINB5, KIT, MUC1, S100A1, S100B
23tamoxifen44 49 28 1114.3MUC1, ERBB3, SERPINB5, CEACAM3, KRT14, VIM
24reticulin4411.3ACTC1, MUC1, KRT7, VIM, S100B
25methionine4411.3S100B, VIM, SERPINA3, KRT14, RASSF1, KIT
26serine4411.3S100B, NID1, RASSF1, KRT14, SERPINA3
27steroid4411.2CEACAM3, ERBB3, SERPINB5, ACTC1, SERPINA3
28s 1004411.2S100B, MUC1, ACTC1, VIM
292-methoxyethanol4411.2S100A1, VIM, ACTC1, KRT14
30agar4411.2VIM, MUC1, RASSF1, ERBB3, LGALS3
31glycogen44 2412.1KIT, KRT7, ACTC1
32orcein4411.1S100B, ACTC1, VIM
33eosin4411.0VIM, S100B, MUC1
34heparin44 28 11 2414.0SERPINA3, NID1, S100B, ERBB3
35cytosine44 2412.0SERPINB5, CEACAM3, KRT14, RASSF1
36biotin44 11 2413.0ACTC1, MUC1, VIM, S100A1
37sialic acid4411.0KRT7, CEACAM3
38toluidine4411.0VIM, S100A1, KIT
39gold4411.0CEACAM3, KIT, MUC1, SERPINA3
40doxorubicin44 49 1113.0VIM, KRT20, ERBB3, CEACAM3, KIT
41creatinine4411.0SERPINA3, ACTC1, CEACAM3
42acetylcholine44 49 28 11 2414.9ERBB3, S100A1, SERPINA3
43streptavidin4410.9KRT20, KRT7, CEACAM3
44folate4410.9RASSF1, SERPINA3, MUC1, VIM
45actomyosin4410.9VIM, ACTC1, S100A1
46proline4410.8VIM, S100B, PIN1, LGALS3, KRT14
475-aza-2deoxycytidine4410.8KRT7, RASSF1, VIM, SERPINB5
48acth4410.8CEACAM3, LGALS3, MUC1, S100B
49indium4410.5MUC1, CEACAM3
50valine4410.5VIM, S100B, KIT, SERPINA3

GO Terms for genes affiliated with Adenoiditis

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16Gene Ontology
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Cellular components related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1SERPINB5, VIM, S100B, SOX4, PIN1, MUC1
2intermediate filamentGO:00588210.8KRT20, KRT7, KRT14, VIM

Biological processes related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.8LGALS3, S100B, PIN1, CYLD, KIT, ERBB3
2regulation of cell proliferationGO:04212710.7ERBB3, KIT, PIN1
3intermediate filament organizationGO:04510910.3KRT20, VIM

Molecular functions related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.7SERPINB5, VIM, S100B, S100A1, SOX4, PIN1
2identical protein bindingGO:04280210.8VIM, S100B, S100A1, RASSF1, ERBB3
3structural constituent of cytoskeletonGO:00520010.7KRT20, KRT14, VIM
4protein homodimerization activityGO:04280310.5S100B, S100A1, KIT, ACCS, ERBB3
5S100 protein bindingGO:04454810.5S100A1, S100B

Products for genes affiliated with Adenoiditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenoiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet