MCID: ADN002
MIFTS: 60

Adenoiditis malady

Summaries for Adenoiditis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. it occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. the infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards: Adenoiditis, also known as chronic adenoiditis, is related to adenoid cystic carcinoma and squamous cell carcinoma, and has symptoms including difficulty swallowing, swelling and redness. An important gene associated with Adenoiditis is MUC1 (mucin 1, cell surface associated), and among its related pathways are MicroRNAs in cancer and Cytoskeleton remodeling Keratin filaments. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related mouse phenotypes are cellular and normal.

Wikipedia:63 Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is... more...

Aliases & Classifications for Adenoiditis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

adenoiditis 8 10 60
chronic adenoiditis 8 60


External Ids:

Disease Ontology8 DOID:0050145
ICD9CM27 474.01

Related Diseases for Adenoiditis

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17GeneCards, 18GeneDecks
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Diseases related to Adenoiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 286)
idRelated DiseaseScoreTop Affiliating Genes
1adenoid cystic carcinoma31.8CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
2squamous cell carcinoma30.9CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
3adenocarcinoma30.8CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
4basal cell carcinoma30.7LGALS3, ACTC1, KRT20, KRT7
5adenoma30.6CEACAM3, SERPINB5, LGALS3, ACTC1, KRT20, KRT7
6pleomorphic adenoma30.5SERPINB5, ACTC1, KRT14, MUC1, S100A1, S100B
7mucoepidermoid carcinoma30.5ACTC1, KRT7, KRT14, MUC1, S100A1
8papillary carcinoma30.1CEACAM3, SERPINB5, LGALS3, ERBB3, ACTC1, KRT20
9melanoma30.1CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
10angiosarcoma30.0SERPINA3, ACTC1, KRT14, MUC1, VIM
11spiradenoma30.0CYLD
12lung adenocarcinoma29.9CEACAM3, ERBB3, KRT20, KRT7, RASSF1, MUC1
13syringoma29.9CEACAM3, KRT14, MUC1, S100A1, S100B
14neuroendocrine carcinoma29.9KRT20, KRT7, KIT, MUC1, S100B
15transitional cell carcinoma29.9CEACAM3, ERBB3, KRT20, KRT7, KRT14
16papilloma29.9ACTC1, KRT20, KRT14, RASSF1
17spindle cell carcinoma29.9ACTC1, MUC1, VIM
18adenosquamous carcinoma29.9KRT20, KRT7, MUC1
19epithelial-myoepithelial carcinoma29.9KRT14
20breast cancer29.7CEACAM3, SERPINB5, LGALS3, ERBB3, KRT7, KRT14
21sarcoma29.7SERPINB5, ERBB3, ACTC1, KIT, MUC1, S100A1
22lung small cell carcinoma29.7CEACAM3, KRT20, KRT7, KRT14, RASSF1, KIT
23myoepithelioma29.7SERPINB5, ACTC1, KRT14, S100A1, S100B, VIM
24meningioma29.7MUC1, S100A1, S100B, VIM
25rhabdomyosarcoma29.7ERBB3, ACTC1, S100A1, S100B, VIM
26leukemia29.7SERPINA3, KRT14, KIT
27papillary thyroid carcinoma29.7LGALS3, RASSF1, S100A1
28large cell carcinoma29.7CEACAM3, KRT20, KRT7
29neurofibromatosis29.7KRT14, KIT, S100B
30craniopharyngioma29.7KRT14
31brooke-spiegler syndrome29.7CYLD
32inverted papilloma29.7KRT20
33pneumonia29.7MUC1
34cholesteatoma29.7LGALS3, KRT14, S100A1
35adenoid squamous cell carcinoma10.6
36breast adenoid cystic carcinoma10.6
37lacrimal gland adenoid cystic carcinoma10.6
38adenoid basal cell carcinoma10.5
39lung adenoid cystic carcinoma10.5
40tonsillitis10.5
41trachea adenoid cystic carcinoma10.5
42otitis media10.5
43pleomorphic adenoma carcinoma10.4
44cystic basal cell carcinoma10.4
45pleomorphic carcinoma10.4
46maxillary sinus adenoid cystic carcinoma10.3
47bartholin's gland adenoid cystic carcinoma10.3
48cervical adenoid cystic carcinoma10.3
49laryngeal adenoid cystic carcinoma10.3
50prostate adenoid cystic carcinoma10.3

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to adenoiditis

Clinical Features for Adenoiditis

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8Disease Ontology
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Symptoms:

8
  • difficulty swallowing
  • swelling
  • redness
  • pain

Drugs & Therapeutics for Adenoiditis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenoiditis

Drug clinical trials:

Search ClinicalTrials for Adenoiditis

Search NIH Clinical Center for Adenoiditis

Search CenterWatch for Adenoiditis

Genetic Tests for Adenoiditis

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Anatomical Context for Adenoiditis

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32MalaCards
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MalaCards organs/tissues related to Adenoiditis:

32
Salivary gland, Breast, Lung, Tonsil, Trachea, Skin, Tongue, Cervix, Endothelial, Liver, Bone, Prostate, Lymph node, Thyroid, Kidney, Smooth muscle, T cells, B cells, Testis, Nk cells, Testes, Pancreas, Bone marrow, Thymus, Brain, Spinal cord, Heart, Skeletal muscle

Animal Models for Adenoiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenoiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.6SERPINB5, ERBB3, ACTC1, KRT7, KRT14, RASSF1
2MP:000287311.3CYLD, KIT, RASSF1, ACTC1, S100A1, ERBB3
3MP:000538511.2NID1, LGALS3, RASSF1, VIM, S100A1, ERBB3
4MP:001077111.0ERBB3, S100B, SOX4, PIN1, KRT14
5MP:000538111.0CYLD, KRT14, MUC1, SOX4, ERBB3, LGALS3
6MP:000539110.9KIT, MUC1, PIN1, NID1, SOX4, KRT14
7MP:000538810.8ERBB3, LGALS3, CYLD, KRT14
8MP:000537610.8CYLD, KRT14, ACTC1, SOX4
9MP:000200610.6KIT, CYLD, MUC1, ERBB3, RASSF1, KRT14

Publications for Adenoiditis

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50PubMed
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Articles related to Adenoiditis:

(show top 50)    (show all 843)
idTitleAuthorsYear
1
Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines. (24065118)
2013
2
Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor. (23835861)
2013
3
Molecular characteristics of homologous salivary adenoid cystic carcinoma cell lines with different lung metastasis ability. (23673996)
2013
4
Salivary adenoid cystic carcinoma with an early phase of high-grade transformation: case report with an immunohistochemical analysis. (23819679)
2013
5
Adenoid cystic carcinoma of palate. (23633876)
2013
6
Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome? (24325947)
2013
7
Dysphagia due to adenoid cystic carcinoma of the base of the tongue. (22737963)
2012
8
Influence of Ginkgo biloba extract on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma of lacrimal gland. (23146805)
2012
9
Adenoid cystic carcinoma of the breast in reduction mammoplasty. (23078292)
2012
10
A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. (22179977)
2012
11
Primary cutaneous adenoid cystic carcinoma of the upper lid: a case report and literature review. (22228272)
2012
12
An unusual case of exclusive liver metastases from adenoid cystic carcinoma of the submandibular gland: a role for surgery? Report of a case. (21431502)
2011
13
Cytodiagnosis of intracranial metastatic adenoid cystic carcinoma: Spread from a primary tumor in the lacrimal gland. (22090696)
2011
14
Clinical significance of Myb protein and downstream target genes in salivary adenoid cystic carcinoma. (21785271)
2011
15
Phase II study of cisplatin and imatinib in advanced salivary adenoid cystic carcinoma. (21071117)
2011
16
The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma. (21618541)
2011
17
Expression of p38MAPK in salivary adenoid cystic carcinoma and their significance]. (21575499)
2011
18
Silencing Id-1 with RNA interference inhibits adenoid cystic carcinoma in mice. (20189601)
2011
19
Nef from SIV(mac239) decreases proliferation and migration of adenoid-cystic carcinoma cells and inhibits angiogenesis. (21763177)
2011
20
Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca2+-evoked p38 signaling pathway. (21279332)
2011
21
Adenoid cystic carcinoma of trachea treated with tumor curettage and adjuvant intensity modulated radiation therapy. (21079533)
2011
22
Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review. (21147032)
2011
23
Prognostic significance of nuclear survivin expression in resected adenoid cystic carcinoma of the head and neck. (21034499)
2010
24
Role of MMP9 on invadopodia formation in cells from adenoid cystic carcinoma. Study by laser scanning confocal microscopy. (19658178)
2010
25
Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands. (20824047)
2010
26
Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: its implication in tumor progression and angiogenesis. (20851535)
2010
27
NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid cystic carcinoma cells and enhances endothelial cell motility in vitro. (19317804)
2009
28
Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. (19360297)
2009
29
Coordinated expression of activated mitogen-activated protein kinases in salivary gland adenoid cystic carcinoma. (18657296)
2008
30
Adenoid cystic carcinoma of the external auditory canal. (19082366)
2008
31
Phase II study on gemcitabine in recurrent and/or metastatic adenoid cystic carcinoma of the head and neck (EORTC 24982). (18819792)
2008
32
Intraoral adenoid cystic carcinoma: prognostic factors and outcome. (18329324)
2008
33
A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands. (16757202)
2007
34
Spatial organisation of microbiota in quiescent adenoiditis and tonsillitis. (16698947)
2007
35
DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma. (17545515)
2007
36
Medical image. A case of adenoid cystic carcinoma of the lacrimal gland: MRI findings. (17653256)
2007
37
Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes]. (17067458)
2006
38
Analysis of differential expression genes related to different metastasis potential of adenoid cystic carcinoma using restriction fragments differential display PCR]. (17029196)
2006
39
Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. (17121916)
2006
40
Clinical and microdissection genotyping analyses of the effect of intra-arterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma. (17057810)
2005
41
Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma. (15959912)
2005
42
Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma. (15044918)
2004
43
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: a review and comparison of immunohistochemical markers. (12167416)
2002
44
Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (11463451)
2001
45
KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. (10530560)
1999
46
Assessment of proliferative activity using the MIB1 antibody help to distinguish polymorphous low grade adenocarcinoma from adenoid cystic carcinoma of salivary glands. (9505262)
1997
47
Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma]. (11189300)
1997
48
Immunohistochemical localization of estradiol, progesterone, and progesterone receptor in human salivary glands and salivary adenoid cystic carcinomas. (1322800)
1992
49
An immunohistochemical study of the distribution of lysozyme, lactoferrin, alpha 1-antitrypsin and alpha 1-antichymotrypsin in salivary adenoid cystic carcinoma. (1665225)
1991
50
Adenoid squamous-cell carcinoma (adenocanthoma) of the oral labial mucosa. A clinicopathologic study of fifteen cases. (5285191)
1971

Genetic Variations for Adenoiditis

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Expression for genes affiliated with Adenoiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for genes affiliated with Adenoiditis

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29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Adenoiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8SERPINB5, ERBB3, RASSF1, SOX4, VIM
210.7KRT14, KRT7, VIM
310.6S100B, LGALS3

Compounds for genes affiliated with Adenoiditis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Adenoiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.0S100B, S100A1, SOX4, MUC1, KIT, KRT14
2paraffin4411.9KRT20, ACTC1, ERBB3, LGALS3, SERPINA3, SERPINB5
3calcium44 49 11 2414.7S100A1, LGALS3, ACTC1, KRT14, KIT, MUC1
4hematoxylin4411.7S100A1, MUC1, CEACAM3, S100B, VIM, KIT
5vegf4411.7MUC1, VIM, KIT, S100B, KRT7, KRT20
6retinoic acid44 2412.7S100B, LGALS3, ACTC1, KRT7, KRT14, VIM
7tyrosine4411.7ACTC1, S100A1, MUC1, KIT, KRT14, KRT7
8alanine4411.6ERBB3, SERPINA3, LGALS3, VIM, S100B, PIN1
9mucicarmine4411.6ACTC1, KRT20, KRT7, KRT14, MUC1, S100A1
10testosterone44 59 11 2414.5ACTC1, KRT20, KRT7, KIT, MUC1, VIM
11threonine4411.5KRT14, ERBB3, LGALS3, S100B, RASSF1, KIT
12formaldehyde44 2412.5ACTC1, KRT20, KRT7, LGALS3, S100B, KIT
13b 7234411.5CEACAM3, ACTC1, KRT20, KRT7, S100A1, MUC1
14lipid4411.5MUC1, VIM, SERPINB5, SERPINA3, LGALS3, ERBB3
15iron44 2412.5S100B, S100A1, KRT14, VIM, KRT20, ACTC1
16cysteine4411.4MUC1, SERPINA3, KRT14, KIT, VIM, S100B
17matrigel4411.4ACTC1, KRT7, VIM, NID1, MUC1, SERPINB5
18glucose4411.4KRT14, SERPINA3, KRT7, MUC1, ACTC1, CEACAM3
19aspartate4411.4PIN1, CEACAM3, ACCS, NID1, S100B, VIM
20oligonucleotide4411.3VIM, SERPINA3, LGALS3, ERBB3, KIT, SOX4
21methotrexate44 49 1113.3SERPINA3, VIM, MUC1, KIT, KRT7, CEACAM3
22nitric oxide44 11 2413.3CEACAM3, SERPINB5, KIT, MUC1, S100A1, S100B
23tamoxifen44 49 28 1114.3MUC1, ERBB3, SERPINB5, CEACAM3, KRT14, VIM
24reticulin4411.3ACTC1, MUC1, KRT7, VIM, S100B
25methionine4411.3S100B, VIM, SERPINA3, KRT14, RASSF1, KIT
26serine4411.3S100B, NID1, RASSF1, KRT14, SERPINA3
27steroid4411.2CEACAM3, ERBB3, SERPINB5, ACTC1, SERPINA3
28s 1004411.2S100B, MUC1, ACTC1, VIM
292-methoxyethanol4411.2S100A1, VIM, ACTC1, KRT14
30agar4411.2VIM, MUC1, RASSF1, ERBB3, LGALS3
31glycogen44 2412.1KIT, KRT7, ACTC1
32orcein4411.1S100B, ACTC1, VIM
33eosin4411.0VIM, S100B, MUC1
34heparin44 28 11 2414.0SERPINA3, NID1, S100B, ERBB3
35cytosine44 2412.0SERPINB5, CEACAM3, KRT14, RASSF1
36biotin44 11 2413.0ACTC1, MUC1, VIM, S100A1
37sialic acid4411.0KRT7, CEACAM3
38toluidine4411.0VIM, S100A1, KIT
39gold4411.0CEACAM3, KIT, MUC1, SERPINA3
40doxorubicin44 49 1113.0VIM, KRT20, ERBB3, CEACAM3, KIT
41creatinine4411.0SERPINA3, ACTC1, CEACAM3
42acetylcholine44 49 28 11 2414.9ERBB3, S100A1, SERPINA3
43streptavidin4410.9KRT20, KRT7, CEACAM3
44folate4410.9RASSF1, SERPINA3, MUC1, VIM
45actomyosin4410.9VIM, ACTC1, S100A1
46proline4410.8VIM, S100B, PIN1, LGALS3, KRT14
475-aza-2deoxycytidine4410.8KRT7, RASSF1, VIM, SERPINB5
48acth4410.8CEACAM3, LGALS3, MUC1, S100B
49indium4410.5MUC1, CEACAM3
50valine4410.5VIM, S100B, KIT, SERPINA3

GO Terms for genes affiliated with Adenoiditis

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16Gene Ontology
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Cellular components related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1SERPINB5, VIM, S100B, SOX4, PIN1, MUC1
2intermediate filamentGO:00588210.8KRT20, KRT7, KRT14, VIM

Biological processes related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.8KIT, S100B, LGALS3, ERBB3, PIN1, CYLD
2regulation of cell proliferationGO:04212710.7PIN1, KIT, ERBB3
3intermediate filament organizationGO:04510910.3KRT20, VIM

Molecular functions related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.7SOX4, VIM, S100B, S100A1, PIN1, MUC1
2identical protein bindingGO:04280210.8S100B, VIM, ERBB3, RASSF1, S100A1
3structural constituent of cytoskeletonGO:00520010.7VIM, KRT14, KRT20
4protein homodimerization activityGO:04280310.5ERBB3, ACCS, KIT, S100A1, S100B
5S100 protein bindingGO:04454810.5S100A1, S100B

Products for genes affiliated with Adenoiditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenoiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet