MCID: ADN002
MIFTS: 36

Adenoiditis

Categories: Respiratory diseases

Aliases & Classifications for Adenoiditis

MalaCards integrated aliases for Adenoiditis:

Name: Adenoiditis 12 14 69
Chronic Adenoiditis 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050145
ICD10 33 J35.02
ICD9CM 35 474.01
SNOMED-CT 64 195794009 232420002
UMLS 69 C0396023

Summaries for Adenoiditis

Disease Ontology : 12 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards based summary : Adenoiditis, also known as chronic adenoiditis, is related to adenoid hypertrophy and salivary gland adenoid cystic carcinoma. An important gene associated with Adenoiditis is FCN2 (Ficolin 2), and among its related pathways/superpathways is Tuberculosis. The drugs Dexmedetomidine and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Wikipedia : 72 Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is... more...

Related Diseases for Adenoiditis

Diseases related to Adenoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
id Related Disease Score Top Affiliating Genes
1 adenoid hypertrophy 12.3
2 salivary gland adenoid cystic carcinoma 12.2
3 cervical adenoid cystic carcinoma 11.9
4 maxillary sinus adenoid cystic carcinoma 11.9
5 lacrimal gland adenoid cystic carcinoma 11.9
6 adenoid basal cell carcinoma 11.9
7 breast adenoid cystic carcinoma 11.9
8 esophageal adenoid cystic carcinoma 11.9
9 adenoid squamous cell carcinoma 11.9
10 laryngeal adenoid cystic carcinoma 11.8
11 bartholin's gland adenoid cystic carcinoma 11.8
12 prostate adenoid cystic carcinoma 11.8
13 lung adenoid cystic carcinoma 11.8
14 trachea adenoid cystic carcinoma 11.8
15 ethmoid sinus adenoid cystic carcinoma 11.7
16 adenoid cystic carcinoma of the corpus uteri 11.7
17 adenoid basal carcinoma of the cervix uteri 11.7
18 lymph node adenoid cystic carcinoma 11.7
19 cervical adenoid basal carcinoma 11.6
20 sublingual gland adenoid cystic carcinoma 11.6
21 parotid gland adenoid cystic carcinoma 11.6
22 tonsillitis 11.5
23 multiple familial trichoepithelioma 11.4
24 trichoepithelioma, multiple familial, 1 11.3
25 sleep apnea 11.1
26 paranasal sinus cancer 10.9
27 cutaneous adenocystic carcinoma 10.9
28 plague 10.7
29 prostate cancer, hereditary, 13 10.7
30 calcifying epithelial odontogenic tumor 10.7
31 prostate cancer, hereditary, 2 10.7
32 prostate cancer, hereditary, 11 10.7
33 prostate cancer 1 10.7
34 prostate cancer 10.7
35 prostate cancer, hereditary, 12 10.7
36 squamous cell carcinoma 10.3
37 adenocarcinoma 10.2
38 otitis media 10.2
39 polymorphous low-grade adenocarcinoma 10.2
40 adenoma 10.1
41 basal cell carcinoma 10.1
42 pleomorphic adenoma 10.1
43 chronic conjunctivitis 10.0
44 mucoepidermoid carcinoma 10.0
45 nasopharyngitis 10.0
46 maturity-onset diabetes of the young, type viii 10.0 CARD9 CLEC7A
47 endotheliitis 9.9
48 rhinitis 9.9
49 intestinal botulism 9.9 CARD9 CLEC7A
50 sinusitis 9.9

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to Adenoiditis

Symptoms & Phenotypes for Adenoiditis

GenomeRNAi Phenotypes related to Adenoiditis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.4 LY75
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.4 TYROBP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.4 LY75
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.4 LY75
5 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.4 LY75 TYROBP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.4 LY75
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 LY75
8 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.4 TYROBP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.4 TYROBP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 LY75
11 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.4 LY75

MGI Mouse Phenotypes related to Adenoiditis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 CARD9 CLEC7A CNOT4 LY75 TYROBP
2 immune system MP:0005387 9.02 CARD9 CLEC7A CNOT4 LY75 TYROBP

Drugs & Therapeutics for Adenoiditis

Drugs for Adenoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
2 Adrenergic Agents Phase 4
3 Adrenergic Agonists Phase 4
4 Adrenergic alpha-2 Receptor Agonists Phase 4
5 Adrenergic alpha-Agonists Phase 4
6 Analgesics Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Central Nervous System Depressants Phase 4
9 Hypnotics and Sedatives Phase 4
10 Neurotransmitter Agents Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Pharmaceutical Solutions Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation Recruiting NCT02162433 Phase 4 Normal Saline;Dexmedetomidine

Search NIH Clinical Center for Adenoiditis

Genetic Tests for Adenoiditis

Anatomical Context for Adenoiditis

MalaCards organs/tissues related to Adenoiditis:

39
Salivary Gland, Breast, Lung, Tonsil, Trachea, Skin, Tongue

Publications for Adenoiditis

Articles related to Adenoiditis:

(show top 50) (show all 1038)
id Title Authors Year
1
Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. ( 28098165 )
2017
2
Adenoid ameloblastoma with dentinoid: A rare hybrid variant. ( 28932051 )
2017
3
Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography. ( 28382475 )
2017
4
Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma. ( 28168897 )
2017
5
Breast Adenoid Cystic Carcinoma: A Rare Case Report and Review of the Literature. ( 28798006 )
2017
6
c-Myb Overexpression in Cytology Smears of Tracheobronchial and Pulmonary Adenoid Cystic Carcinomas. ( 27974718 )
2017
7
Adenoid hypertrophy in children and allergic rhinitis. ( 28887688 )
2017
8
The pathogens profile in children with otitis media with effusion and adenoid hypertrophy. ( 28231295 )
2017
9
Correlation and reliability of cone-beam computed tomography nasopharyngeal volumetric and area measurements as determined by commercial software against nasopharyngoscopy-supported diagnosis of adenoid hypertrophy. ( 28651774 )
2017
10
Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells. ( 28277192 )
2017
11
"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? ( 28474190 )
2017
12
Association between high expression of phosphorylated Akt and mammalian target of rapamycin and improved survival in salivary gland adenoid cystic carcinoma. ( 28230926 )
2017
13
Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )
2017
14
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma. ( 27898620 )
2017
15
Adenoids in paediatric chronic rhinosinusitis, deep neck space infections and optimising otowicks in otitis externa. ( 28841132 )
2017
16
Mithramycin inhibits epithelial-to-mesenchymal transition and invasion by downregulating SP1 and SNAI1 in salivary adenoid cystic carcinoma. ( 28631560 )
2017
17
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma. ( 28820917 )
2017
18
Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. ( 28228352 )
2017
19
Correction: Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. ( 28642227 )
2017
20
MYB, MYBL1, MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma. ( 28594149 )
2017
21
Clinicopathological characteristics of KIT and protein kinase C-I' expression in adenoid cystic carcinoma: comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumour. ( 28561935 )
2017
22
HIF1I+ in Tumorigenesis of Adenoid Cystic Carcinoma. ( 28179306 )
2017
23
Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis. ( 28236426 )
2017
24
Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma. ( 28152077 )
2017
25
Significant association between SCGB1D4 gene polymorphisms and susceptibility to adenoid hypertrophy in a pediatric population. ( 28263490 )
2017
26
Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors. ( 27870570 )
2017
27
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. ( 28498281 )
2017
28
B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway. ( 28386362 )
2017
29
Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study. ( 28151884 )
2017
30
Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population. ( 28823693 )
2017
31
Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis. ( 28600602 )
2017
32
Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with epithelial-mesenchymal transition-related factors. ( 27180058 )
2016
33
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. ( 26829750 )
2016
34
Slug silencing inhibited perineural invasion through regulation of EMMPRIN expression in human salivary adenoid cystic carcinoma. ( 26349748 )
2016
35
Integrative versus Conventional Therapy of Chronic Otitis Media with Effusion and Adenoid Hypertrophy in Children: A Prospective Observational Study. ( 27607438 )
2016
36
Does adenoid hypertrophy affect disease severity in children with allergic rhinitis? ( 27405740 )
2016
37
Expression of Autophagy and Reactive Oxygen Species-Related Proteins in Lacrimal Gland Adenoid Cystic Carcinoma. ( 26847304 )
2016
38
Nonencapsulated Streptococcus pneumoniae as a cause of chronic adenoiditis. ( 27144125 )
2016
39
The common genetic variants of toll-like receptor and susceptibilityto adenoid hypertrophy: a hospital-based cohort study. ( 27966312 )
2016
40
The unique luminal staining pattern of cytokeratin 5/6 in adenoid cystic carcinoma of the breast may aid in differentiating it from its mimickers. ( 27240462 )
2016
41
Sporadic Burkitt Lymphoma Presenting as Acute Pancreatitis, Concurrent Sinusitis, and Enlarged Adenoids. ( 27213067 )
2016
42
Differing Lymphatic Vessels Density in Salivary Adenoid Cystic Carcinoma and Pleomorphic Adenoma. ( 27837476 )
2016
43
Effect of adenoid hypertrophy and pulmonary function tests in children with mild asthma. ( 27888821 )
2016
44
Adenoid cystic carcinoma: A rare late presentation of the mobile tongue. ( 27195216 )
2016
45
Type III TGF-I^ receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-I_B signaling. ( 26531330 )
2016
46
Re-affirming the necessity of sending even minor surgical specimens for histopathology: a case of inverted papilloma of the adenoids. ( 27685930 )
2016
47
Accuracy and reliability of orthodontists using cone-beam computerized tomography for assessment of adenoid hypertrophy. ( 27871704 )
2016
48
Solid Variant of Adenoid Cystic Carcinoma: Difficulties in Diagnostic Recognition. ( 27069025 )
2016
49
Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. ( 26631609 )
2016
50
Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track. ( 26954362 )
2016

Variations for Adenoiditis

Expression for Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for Adenoiditis

Pathways related to Adenoiditis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.88 CARD9 CLEC7A

GO Terms for Adenoiditis

Biological processes related to Adenoiditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 CARD9 CLEC7A
2 defense response to Gram-positive bacterium GO:0050830 9.16 CARD9 FCN2
3 immune system process GO:0002376 9.13 CARD9 CLEC7A FCN2
4 innate immune response GO:0045087 8.92 CARD9 CLEC7A FCN2 TYROBP

Molecular functions related to Adenoiditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.8 CLEC7A FCN2 LY75

Sources for Adenoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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