MCID: ADN002
MIFTS: 60

Adenoiditis malady

Summaries for Adenoiditis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. it occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. the infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.

MalaCards: Adenoiditis, also known as chronic adenoiditis, is related to adenoid cystic carcinoma and squamous cell carcinoma, and has symptoms including difficulty swallowing, swelling and redness. An important gene associated with Adenoiditis is MUC1 (mucin 1, cell surface associated), and among its related pathways are MicroRNAs in cancer and Cytoskeleton remodeling Keratin filaments. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, breast and lung, and related mouse phenotypes are cellular and normal.

Wikipedia:63 Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is... more...

Aliases & Classifications for Adenoiditis

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

adenoiditis 8 10 60
chronic adenoiditis 8 60


External Ids:

Disease Ontology8 DOID:0050145
ICD9CM27 474.01

Related Diseases for Adenoiditis

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17GeneCards, 18GeneDecks
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Diseases related to Adenoiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 286)
idRelated DiseaseScoreTop Affiliating Genes
1adenoid cystic carcinoma31.8CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
2squamous cell carcinoma30.9CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
3adenocarcinoma30.8CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
4basal cell carcinoma30.7LGALS3, ACTC1, KRT20, KRT7
5adenoma30.6CEACAM3, SERPINB5, LGALS3, ACTC1, KRT20, KRT7
6pleomorphic adenoma30.5SERPINB5, ACTC1, KRT14, MUC1, S100A1, S100B
7mucoepidermoid carcinoma30.5ACTC1, KRT7, KRT14, MUC1, S100A1
8papillary carcinoma30.1CEACAM3, SERPINB5, LGALS3, ERBB3, ACTC1, KRT20
9melanoma30.1CEACAM3, SERPINB5, SERPINA3, LGALS3, ERBB3, ACTC1
10angiosarcoma30.0SERPINA3, ACTC1, KRT14, MUC1, VIM
11spiradenoma30.0CYLD
12lung adenocarcinoma29.9CEACAM3, ERBB3, KRT20, KRT7, RASSF1, MUC1
13syringoma29.9CEACAM3, KRT14, MUC1, S100A1, S100B
14neuroendocrine carcinoma29.9KRT20, KRT7, KIT, MUC1, S100B
15transitional cell carcinoma29.9CEACAM3, ERBB3, KRT20, KRT7, KRT14
16papilloma29.9ACTC1, KRT20, KRT14, RASSF1
17spindle cell carcinoma29.9ACTC1, MUC1, VIM
18adenosquamous carcinoma29.9KRT20, KRT7, MUC1
19epithelial-myoepithelial carcinoma29.9KRT14
20breast cancer29.7CEACAM3, SERPINB5, LGALS3, ERBB3, KRT7, KRT14
21sarcoma29.7SERPINB5, ERBB3, ACTC1, KIT, MUC1, S100A1
22lung small cell carcinoma29.7CEACAM3, KRT20, KRT7, KRT14, RASSF1, KIT
23myoepithelioma29.7SERPINB5, ACTC1, KRT14, S100A1, S100B, VIM
24meningioma29.7MUC1, S100A1, S100B, VIM
25rhabdomyosarcoma29.7ERBB3, ACTC1, S100A1, S100B, VIM
26leukemia29.7SERPINA3, KRT14, KIT
27papillary thyroid carcinoma29.7LGALS3, RASSF1, S100A1
28large cell carcinoma29.7CEACAM3, KRT20, KRT7
29neurofibromatosis29.7KRT14, KIT, S100B
30craniopharyngioma29.7KRT14
31brooke-spiegler syndrome29.7CYLD
32inverted papilloma29.7KRT20
33pneumonia29.7MUC1
34cholesteatoma29.7LGALS3, KRT14, S100A1
35adenoid squamous cell carcinoma10.6
36breast adenoid cystic carcinoma10.6
37lacrimal gland adenoid cystic carcinoma10.6
38adenoid basal cell carcinoma10.5
39lung adenoid cystic carcinoma10.5
40tonsillitis10.5
41trachea adenoid cystic carcinoma10.5
42otitis media10.5
43pleomorphic adenoma carcinoma10.4
44cystic basal cell carcinoma10.4
45pleomorphic carcinoma10.4
46maxillary sinus adenoid cystic carcinoma10.3
47bartholin's gland adenoid cystic carcinoma10.3
48cervical adenoid cystic carcinoma10.3
49laryngeal adenoid cystic carcinoma10.3
50prostate adenoid cystic carcinoma10.3

Graphical network of the top 20 diseases related to Adenoiditis:



Diseases related to adenoiditis

Clinical Features for Adenoiditis

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8Disease Ontology
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Symptoms:

8
  • difficulty swallowing
  • swelling
  • redness
  • pain

Drugs & Therapeutics for Adenoiditis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenoiditis

Drug clinical trials:

Search ClinicalTrials for Adenoiditis

Search NIH Clinical Center for Adenoiditis

Search CenterWatch for Adenoiditis

Genetic Tests for Adenoiditis

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Anatomical Context for Adenoiditis

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32MalaCards
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MalaCards organs/tissues related to Adenoiditis:

32
Salivary gland, Breast, Lung, Tonsil, Trachea, Skin, Tongue, Cervix, Endothelial, Liver, Bone, Prostate, Lymph node, Thyroid, Kidney, Smooth muscle, T cells, B cells, Testis, Nk cells, Testes, Pancreas, Bone marrow, Thymus, Brain, Spinal cord, Heart, Skeletal muscle

Animal Models for Adenoiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenoiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.6SERPINB5, VIM, SOX4, NID1, PIN1, CYLD
2MP:000287311.3S100B, S100A1, SOX4, MUC1, CYLD, KIT
3MP:000538511.2VIM, S100A1, SOX4, NID1, KIT, RASSF1
4MP:001077111.0S100B, SOX4, PIN1, KRT14, ERBB3
5MP:000538111.0SOX4, MUC1, CYLD, KIT, KRT14, ERBB3
6MP:000539110.9VIM, SOX4, NID1, PIN1, MUC1, KIT
7MP:000538810.8CYLD, KRT14, ERBB3, LGALS3
8MP:000537610.8ACTC1, KRT14, CYLD, SOX4
9MP:000200610.6MUC1, CYLD, KIT, RASSF1, KRT14, ERBB3

Publications for Adenoiditis

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50PubMed
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Articles related to Adenoiditis:

(show top 50)    (show all 843)
idTitleAuthorsYear
1
The CCL5/CCR5 axis contributes to the perineural invasion of human salivary adenoid cystic carcinoma. (24337063)
2014
2
A case of adenoid cystic carcinoma arising from the nasopharynx. (23990616)
2013
3
Adenoid cystic carcinoma of the skull base mimicking temporomandibular disorder. (23636713)
2013
4
Primary cutaneous adenoid cystic carcinoma: an unusual case. (23374947)
2013
5
Expression of autophagy and ER stress-related proteins in primary salivary adenoid cystic carcinoma. (23089287)
2012
6
Adenoid cystic carcinoma of the lacrimal gland: CT and MRI findings. (21725943)
2012
7
Definitive radiotherapy for unresected adenoid cystic carcinoma of the trachea. (22553266)
2012
8
Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance. (23110497)
2012
9
Primary cutaneous adenoid cystic carcinoma of the chest wall: a rare entity. (23361287)
2012
10
The utility of nasopharyngeal culture in the management of chronic adenoiditis. (22784508)
2012
11
EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo. (22198615)
2012
12
Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico. (23243344)
2012
13
Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas. (22096672)
2011
14
An unusual case of adenoid cystic carcinoma with hard palate perforation. (21252852)
2011
15
Adenoid cystic carcinoma: a rare clinical entity and literature review. (21353624)
2011
16
Fine-needle aspiration biopsy of adenoid cystic carcinoma of the palatine tonsil. (21623122)
2011
17
Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinoma. (21550270)
2011
18
A phase 2 trial of bortezomib followed by the addition of doxorubicin at progression in patients with recurrent or metastatic adenoid cystic carcinoma of the head and neck: a trial of the Eastern Cooperative Oncology Group (E1303). (21246525)
2011
19
Surgery alone provides long-term survival rates comparable to those of surgery plus postoperative radiotherapy for patients with adenoid cystic carcinoma of the palate. (21257338)
2011
20
Adenoid cystic carcinoma of the subglottic larynx: a case report and review of the literature. (20397134)
2010
21
Metastatic adenoid cystic carcinoma of kidney masquerading as renal cell carcinoma. (21045436)
2010
22
Adenoid cystic carcinoma of the breast: clinical, histological and immunohistochemical characterization]. (20223349)
2010
23
Photodynamic therapy as consolidation treatment for primary cutaneous adenoid cystic carcinoma: a case report. (20929386)
2010
24
Prognostic value of pathologic characteristics and resection margins in tracheal adenoid cystic carcinoma. (20356756)
2010
25
The development of primary cutaneous adenoid cystic carcinoma in a patient with ankylosing spondylitis treated with etanercept. (19488017)
2009
26
Perineural invasion in adenoid cystic carcinoma of the salivary glands: a valid prognostic indicator? (19692291)
2009
27
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. (19434292)
2009
28
Adenoid cystic carcinoma of the breast. (19224074)
2009
29
Laryngeal adenoid cystic carcinoma in an adolescent. (19155680)
2008
30
Macroglossia caused by adenoid cystic carcinoma. Case report. (18521061)
2008
31
Adenoid cystic carcinoma of the Bartholin's gland: a rare tumor unmarked by persistent vulvar pain in a postmenopausal woman. (18283472)
2008
32
Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. (18084258)
2008
33
Effect of exogenous bFGF on the proliferation of human adenoid cystic carcinoma ACC-2 cells. (18481005)
2008
34
Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck. (17912431)
2007
35
Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. (16996782)
2007
36
Adenoid cystic carcinoma of the Bartholin gland: an overview. (17488169)
2007
37
Primary esophageal adenoid cystic carcinoma. (20485637)
2007
38
Targeting transgene effect of adTERT-TRAIL on salivary adenoid cystic carcinoma cell line SACC-83]. (17663353)
2007
39
Adenoid glioblastoma arising in a patient with neurofibromatosis type-1. (15943792)
2005
40
Oral adenoid squemous carcinoma. Tumor markers and prognosis]. (15045535)
2004
41
Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. (11978546)
2002
42
A case of adenoid cystic carcinoma (ACC) of the breast and review of the utility of preoperative imaging diagnose. (11180772)
2001
43
Infrequent alternations of RB pathway (Rb-p16INK4A-cyclinD1) in adenoid cystic carcinoma of salivary glands. (10928172)
2000
44
A case of adenoid squamous cell carcinoma of the breast skin. (11341233)
2000
45
Neural cell adhesion molecule expression in adenoid cystic carcinoma of the head and neck. (10852510)
2000
46
The tonsils and adenoids as a site of infection and the cause of obstruction]. (9866845)
1998
47
The origin and molecular characterization of adenoid basal carcinoma of the uterine cervix. (9421067)
1997
48
Pleomorphic adenoma and adenoid-cystic carcinoma of salivary glands: immunohistochemical assessment of proliferative activity in comparison with flow-cytometric study. (8652744)
1996
49
Giant adenoid basal cell carcinoma. (8060083)
1994
50
Adenoid squamous cell carcinoma of the lip: report of cases. (4504554)
1972

Genetic Variations for Adenoiditis

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Expression for genes affiliated with Adenoiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoiditis

Search GEO for disease gene expression data for Adenoiditis.

Pathways for genes affiliated with Adenoiditis

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29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Adenoiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8SERPINB5, ERBB3, RASSF1, SOX4, VIM
210.7VIM, KRT14, KRT7
310.6LGALS3, S100B

Compounds for genes affiliated with Adenoiditis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Adenoiditis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2416.0S100B, S100A1, SOX4, MUC1, KIT, KRT14
2paraffin4411.9KRT20, ACTC1, ERBB3, LGALS3, SERPINA3, SERPINB5
3calcium44 49 11 2414.7S100A1, LGALS3, ACTC1, KRT14, KIT, MUC1
4hematoxylin4411.7S100A1, MUC1, CEACAM3, S100B, VIM, KIT
5vegf4411.7MUC1, VIM, KIT, S100B, KRT7, KRT20
6retinoic acid44 2412.7S100B, LGALS3, ACTC1, KRT7, KRT14, VIM
7tyrosine4411.7ACTC1, S100A1, MUC1, KIT, KRT14, KRT7
8alanine4411.6ERBB3, SERPINA3, LGALS3, VIM, S100B, PIN1
9mucicarmine4411.6ACTC1, KRT20, KRT7, KRT14, MUC1, S100A1
10testosterone44 59 11 2414.5ACTC1, KRT20, KRT7, KIT, MUC1, VIM
11threonine4411.5KRT14, ERBB3, LGALS3, S100B, RASSF1, KIT
12formaldehyde44 2412.5ACTC1, KRT20, KRT7, LGALS3, S100B, KIT
13b 7234411.5CEACAM3, ACTC1, KRT20, KRT7, S100A1, MUC1
14lipid4411.5MUC1, VIM, SERPINB5, SERPINA3, LGALS3, ERBB3
15iron44 2412.5S100B, S100A1, KRT14, VIM, KRT20, ACTC1
16cysteine4411.4MUC1, SERPINA3, KRT14, KIT, VIM, S100B
17matrigel4411.4ACTC1, KRT7, VIM, NID1, MUC1, SERPINB5
18glucose4411.4KRT14, SERPINA3, KRT7, MUC1, ACTC1, CEACAM3
19aspartate4411.4PIN1, CEACAM3, ACCS, NID1, S100B, VIM
20oligonucleotide4411.3VIM, SERPINA3, LGALS3, ERBB3, KIT, SOX4
21methotrexate44 49 1113.3SERPINA3, VIM, MUC1, KIT, KRT7, CEACAM3
22nitric oxide44 11 2413.3CEACAM3, SERPINB5, KIT, MUC1, S100A1, S100B
23tamoxifen44 49 28 1114.3MUC1, ERBB3, SERPINB5, CEACAM3, KRT14, VIM
24reticulin4411.3ACTC1, MUC1, KRT7, VIM, S100B
25methionine4411.3S100B, VIM, SERPINA3, KRT14, RASSF1, KIT
26serine4411.3S100B, NID1, RASSF1, KRT14, SERPINA3
27steroid4411.2CEACAM3, ERBB3, SERPINB5, ACTC1, SERPINA3
28s 1004411.2S100B, MUC1, ACTC1, VIM
292-methoxyethanol4411.2S100A1, VIM, ACTC1, KRT14
30agar4411.2VIM, MUC1, RASSF1, ERBB3, LGALS3
31glycogen44 2412.1KIT, KRT7, ACTC1
32orcein4411.1S100B, ACTC1, VIM
33eosin4411.0VIM, S100B, MUC1
34heparin44 28 11 2414.0SERPINA3, NID1, S100B, ERBB3
35cytosine44 2412.0SERPINB5, CEACAM3, KRT14, RASSF1
36biotin44 11 2413.0ACTC1, MUC1, VIM, S100A1
37sialic acid4411.0KRT7, CEACAM3
38toluidine4411.0VIM, S100A1, KIT
39gold4411.0CEACAM3, KIT, MUC1, SERPINA3
40doxorubicin44 49 1113.0VIM, KRT20, ERBB3, CEACAM3, KIT
41creatinine4411.0SERPINA3, ACTC1, CEACAM3
42acetylcholine44 49 28 11 2414.9ERBB3, S100A1, SERPINA3
43streptavidin4410.9KRT20, KRT7, CEACAM3
44folate4410.9RASSF1, SERPINA3, MUC1, VIM
45actomyosin4410.9VIM, ACTC1, S100A1
46proline4410.8VIM, S100B, PIN1, LGALS3, KRT14
475-aza-2deoxycytidine4410.8KRT7, RASSF1, VIM, SERPINB5
48acth4410.8CEACAM3, LGALS3, MUC1, S100B
49indium4410.5MUC1, CEACAM3
50valine4410.5VIM, S100B, KIT, SERPINA3

GO Terms for genes affiliated with Adenoiditis

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16Gene Ontology
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Cellular components related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573711.1SERPINB5, VIM, S100B, SOX4, PIN1, MUC1
2intermediate filamentGO:00588210.8KRT20, KRT7, KRT14, VIM

Biological processes related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.8LGALS3, S100B, PIN1, CYLD, KIT, ERBB3
2regulation of cell proliferationGO:04212710.7ERBB3, KIT, PIN1
3intermediate filament organizationGO:04510910.3KRT20, VIM

Molecular functions related to Adenoiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.7SERPINB5, VIM, S100B, S100A1, SOX4, PIN1
2identical protein bindingGO:04280210.8VIM, S100B, S100A1, RASSF1, ERBB3
3structural constituent of cytoskeletonGO:00520010.7KRT20, KRT14, VIM
4protein homodimerization activityGO:04280310.5S100B, S100A1, KIT, ACCS, ERBB3
5S100 protein bindingGO:04454810.5S100A1, S100B

Products for genes affiliated with Adenoiditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenoiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet