Search MalaCards:
MCID: ADN002

Adenoiditis malady
4 symptoms, 193 genes, 13 tissues, 991 related diseases, 28 phenotypes, 231 articles, clinical trials.

Summaries for Adenoiditis

about this section
Sources:
6Disease Ontology, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
Disease Ontology: An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. it occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. the infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing.6

MalaCards: Adenoiditis, also known as chronic adenoiditis, is related to adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma, and has symptoms including pain, redness and swelling. An important gene associated with Adenoiditis is MUC1 (mucin 1, cell surface associated), and among its related pathways are Molecular Mechanisms of Cancer and Apoptosis and survival Role of CDK5 in neuronal death and survival. The compounds b 723 and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, kidney and lung, and related mouse phenotypes are immune system and integument.

Wikipedia: Adenoiditis is the inflammation of the adenoid tissue, usually caused by an infection. Adenoiditis is...44 more...

Aliases & Descriptions for Adenoiditis

about this section
Sources:
6Disease Ontology, 8DISEASES, 43UMLS, 40SNOMED-CT, 19ICD9CM
See all sources

Aliases & Descriptions:

adenoiditis 6 8 43
chronic adenoiditis 6 43

External Ids:

ICD9CM19 474.01

Related Diseases for Adenoiditis

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to adenoiditis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 988)
idRelated DiseaseScoreTop Affiliating Genes
1adenoid cystic carcinoma41.8PIN1, NCAM1, KIT, PCNA, SERPINB5, SERPINA3
2polymorphous low-grade adenocarcinoma33.3KIT, PCNA, SERPINB5, VIM, MYB, LGALS3
3squamous cell carcinoma32.6SERPINB3, SERPINB4, LGALS1, LGALS3, CDH1, MMP7
4mucoepidermoid carcinoma31.8PCNA, MUC1, MUC5AC, S100A1, CEACAM5, CDKN1B
5pleomorphic adenoma31.6PCNA, SERPINB5, VIM, MUC1, S100A1, S100B
6basaloid squamous cell carcinoma30.6PCNA, BIRC5, BAX, B3GAT1, S100A1, CEACAM7
7angiosarcoma28.8KIT, SERPINA3, VIM, VEGFA, KDR, MUC1
8small cell carcinoma28.3KLF6, NCAM1, KIT, PCNA, VIM, VEGFA
9neurofibromatosis28.3KIT, VIM, VEGFA, B3GAT1, S100B, CDKN2A
10carcinoma27.7PIK3CA, PIR, PIN1, KLF6, NCAM1, REG4
11glioblastoma27.2PIK3CA, KLF6, VEGFA, BIRC5, KDR, LGALS1
12allergic rhinitis26.9VCAM1, IL4, IGES, IGHE, RNASE3
13tonsillitis25.3SERPINB5, VIM, VEGFA, CLU, BCL2, BCL6
14adenoma24.6PIK3CA, NCAM1, REG4, KIT, PCNA, SERPINB5
15adenocarcinoma23.9PIK3CA, PIN1, KLF6, NCAM1, REG4, RELA
16otitis media23.7VCAM1, BMP6, BCL6, MUC1, MUC5AC, LACTB
17atopic dermatitis23.2VCAM1, LGALS3, CD14, ITGA6, FCER2, IL2
18noma22.0PIK3CA, KIT, PCNA, VIM, VEGFA, BIRC5
19nasopharyngitis21.4PIK3CA, KLF6, RELA, KIT, SFN, PCNA
20sinusitis21.1PIK3CA, RELA, PCNA, SERPINB3, SERPINB4, SERPINA3
21dermatitis20.7RELA, SERPINB3, SERPINB4, VIM, VEGFA, VCAM1
22oral squamous cell carcinoma20.5PIK3CA, PIN1, SFN, PCNA, SERPINB3, SERPINB5
23melanoma20.2PIK3CA, PIR, KLF6, NCAM1, RELA, KIT
24rhinitis19.9RELA, VEGFA, VCAM1, KDR, BCL2, MUC1
25neuronitis18.8PIK3CA, PIN1, KLF6, NCAM1, RELA, KIT
26nonencapsulated sclerosing carcinoma15.0SERPINB5, LGALS1, LGALS3, MUC1, MUC16, S100A1
27oxyphilic adenoma14.8KIT, VIM, RASSF1, LGALS3, MUC1, S100A1
28paraganglioma14.7NCAM1, KIT, PCNA, VIM, BCL2, LGALS3
29trichoepithelioma14.7VIM, BCL2, CD34, CDH1, MKI67, CYLD
30aggressive digital papillary adenocarcinoma14.7PCNA, VIM, BIRC5, LGALS3, MUC1, S100A1
31bannayan-riley-ruvalcaba syndrome14.7VIM, BCL2, LGALS1, MUC1, S100B, CD34
32papillary thyroid carcinoma14.6SERPINB5, RASSF1, LGALS3, BAX, S100A1, CDH1
33chromophobe renal cell carcinoma14.6KIT, PCNA, VIM, MUC1, S100A1, CD9
34synovial sarcoma14.6KIT, VIM, RASSF1, BCL2, MUC1, S100B
35renal oncocytoma14.6KIT, PCNA, VIM, MUC1, S100A1, CCND1
36craniopharyngioma14.6PCNA, VIM, LGALS1, LGALS3, CHKA, S100A1
37neuroendocrine carcinoma14.5NCAM1, KIT, CHKA, MUC1, S100B, CEACAM5
38thymic carcinoma14.5KIT, VIM, BCL2, MUC1, S100A1, CEACAM5
39myxopapillary ependymoma14.5NCAM1, VIM, LGALS3, MUC1, S100B, KRT7
40intrahepatic cholangiocarcinoma14.5NCAM1, SFN, SERPINB5, SERPINA3, BIRC5, BCL2
41myoepithelioma14.4PCNA, SERPINB5, VIM, S100A1, S100B, TP53
42syringoma14.4VIM, MUC1, S100A1, S100B, CEACAM3, ESR1
43sarcomatoid renal cell carcinoma14.4KIT, PCNA, VIM, VEGFA, MUC1, S100A1
44carcinoid tumors14.4NCAM1, PCNA, RASSF1, CLDN2, KDR, BCL2
45basal cell carcinoma14.4BCL2, LGALS1, LGALS3, BAK1, BAX, CD34
46sweat gland carcinoma14.4PCNA, MUC1, MUC5AC, S100A1, S100B, ERBB2
47follicular adenoma14.4NCAM1, SERPINB5, LGALS3, CDH1, PTEN, NTRK1
48leiomyosarcoma14.4KIT, PCNA, SERPINB3, SERPINA3, VIM, VEGFA
49desmoplastic small round cell tumor14.4KIT, VIM, MUC1, S100B, ENO2, ERBB2
50bowen syndrome14.4PCNA, CEACAM3, MKI67, KRT7, KRT19, KRT14

Graphical network of the top 20 diseases related to adenoiditis:



Graphical network of diseases related to adenoiditis

Clinical Features for Adenoiditis

about this section
Sources:
6Disease Ontology
See all sources
Symptoms: pain, redness, swelling, difficulty swallowing.6

Drugs & Therapeutics for Adenoiditis

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for adenoiditis

Drug clinical trials:

Search ClinicalTrials for adenoiditis

Search NIH Clinical Center for adenoiditis

Search CenterWatch for adenoiditis

Genetic Tests for Adenoiditis

about this section

Anatomical Context for Adenoiditis

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to adenoiditis:

22
Smooth muscle, Kidney, Lung, Salivary gland, Breast, Skin, Cervix, Tonsil, T cells, B cells, Endothelial, Trachea, Bronchial epithelium

Phenotypes for genes affiliated with Adenoiditis

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to adenoiditis:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1immune system phenotypeMP:0005387INFKIT, SFN, VIM, MYB, BIRC2, CLU
2integument phenotypeMP:0010771INFPIN1, , RELA, KIT, SFN, MYB
3tumorigenesisMP:0002006INFPIK3CA, KIT, SFN, RASSF1, BCL2,
4normal phenotypeMP:0002873INFRELA, VEGFA, MYB, RAX, BIRC2, BIRC3
5digestive/alimentary phenotypeMP:0005381INFKIT, SFN, VEGFA, RAX, BCL2, LGALS3
6reproductive system phenotypeMP:0005389INFPIK3CA, , SFN, VEGFA, PA2G4, BCL6
7liver/biliary system phenotypeMP:0005370INF, KIT, SFN, VEGFA, MYB, BCL6
8embryogenesis phenotypeMP:0005380INFPIK3CA, PIR, , KIT, SFN, SERPINB5
9cardiovascular system phenotypeMP:0005385INFPIK3CA, , RELA, KIT, VIM, VEGFA
10behavior/neurological phenotypeMP:0005386INFPIK3CA, NCAM1, KIT, VIM, RAX, KDR
11pigmentation phenotypeMP:000118610.1KIT, BCL2, L1CAM, CDKN1B, CDKN2A, MDM2
12adipose tissue phenotypeMP:00053759.2PIK3CA, BCL2, SAT1, CDKN1B, CD14, ARID5B
13no phenotypic analysisMP:00030129.1PCNA, VEGFA, VCAM1, MUC1, L1CAM, CD79A
14skeleton phenotypeMP:00053909.0RELA, KIT, SFN, VEGFA, BMP6, KDR
15growth/size phenotypeMP:0005378INFPIK3CA, PIR, PIN1, , RELA, KIT
16craniofacial phenotypeMP:0005382INFKIT, RAX, L1CAM, ARID5B, NRP2, SNAI2
17renal/urinary system phenotypeMP:0005367INFKIT, CLU, BCL2, BAK1, BAX, AXIN1
18nervous system phenotypeMP:0003631INFRELA, KIT, RAX, LGALS1, LGALS3, BAK1
19homeostasis/metabolism phenotypeMP:0005376INFPIK3CA, RELA, KIT, VIM, VEGFA, VCAM1
20respiratory system phenotypeMP:0005388INFBCL6, CD14, CCR4, TP63, , NRP2
21endocrine/exocrine gland phenotypeMP:0005379INFSFN, , , CDK6, CDKN2C, CDKN1B
22hematopoietic system phenotypeMP:0005397INF, KIT, SFN, PCNA, BIRC2, BIRC3
23vision/eye phenotypeMP:0005391INFPIK3CA, PIN1, NCAM1, RELA, KIT, SFN
24mortality/agingMP:0010768INFPIK3CA, , NCAM1, RELA, SFN, SERPINB5
25limbs/digits/tail phenotypeMP:0005371INFRELA, KIT, SFN, VEGFA, PA2G4, BAK1
26cellular phenotypeMP:0005384INFPIK3CA, PIN1, , NCAM1, RELA, KIT
27hearing/vestibular/ear phenotypeMP:0005377INFKIT, SFN, BCL2, BAK1, BAX, AXIN1
28muscle phenotypeMP:0005369INFPIK3CA, RELA, KIT, VIM, VEGFA, BIRC2

Publications for genes affiliated with Adenoiditis

about this section
Sources:
35PubMed
See all sources

Articles related to adenoiditis:

(show top 50)    (show all 231)
idTitleAuthorsYearAffiliating Genes
1CDH12 promotes the invasion of salivary adenoid cysti c carcinoma. (21573496)Wang J.F.... Lu Y.G.2011CDH12
2MYB expression and translocation in adenoid cystic ca rcinomas and other salivary gland tumors with clinicopathologic correlation. (21164292)West R.B.... Le Q.T.2011MYB
3Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. (21572406)Brill L.B.... Frierson H.F.2011MYB
4RNAi-mediated ADAM9 gene silencing inhibits metastasi s of adenoid cystic carcinoma cells. (20422344)Xu Q.... Chen W.2010ADAM9
5Adenoid cystic carcinoma of the breast: clinical, hi stological and immunohistochemical characterization (20223349)Defaud-HAcnon F.... MacGrogan G.2010NOS2
6Correlation between transcription factor Snail1 expre ssion and prognosis in adenoid cystic carcinoma of salivary gland. (20952218)Jiang J.... Liang X.2010SNAI1
7Expression of p-AKT characterizes adenoid cystic carc inomas of head and neck with a higher risk for tumor relapses. (19545368)VAPlker H.U.... Schmidt M.2009TKTL1, PKM
8Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. (19082454)Hu K.... Yu G.Y.2009MAPK3, MAPK1
9Local production of total IgE and specific antibodies to the house dust mite in adenoid tissue. (18657051)Shin S.Y.... Park H.S.2009CD79A, FCER2, RNASE3
10Expression patterns and prognostic significance of inhibitor of apoptosis proteins in adenoid cystic carcinoma and pleomorphic adenoma of lachrymal gland. (18955046)Liao Y.... Luo Q.2009BIRC2, BIRC3, BIRC7
11Effects of genistein on the expressions of cell apop tosis-related proteins in salivary adenoid cystic carcinoma cell line SACC-83 (18470428)Ma J.... Wang Z.Y.2008BCL2, BAX
12Effects of basic fibroblast growth factor on the proliferation of human salivary adenoid cystic carcinoma cell line ACC-2 and extracellular signal-regulated kinase, Cyclin D1, p2waf/cip1 signaling pathway (18605443)Ding L.... Wu X.B.2008CCND1
13Expression of p53 gene with DNA polbeta and CMV prom oter in salivary adenoid cystic carcinoma cells (17375570)Yan B.Z.... Wang X.2007TP53
14Phase II study of lapatinib in recurrent or metastatic epidermal growth factor receptor and/or erbB2 expressing adenoid cystic carcinoma and non adenoid cystic carcinoma malignant tumors of the salivary glands. (17761983)Agulnik M.... Siu L.L.2007ERBB2, EGFR
15SIKVAV, a laminin alpha1-derived peptide, interacts with integrins and increases protease activity of a human salivary gland adenoid cystic carcinoma cell line through the ERK 1/2 signaling pathway. (17591960)Freitas V.M.... Jaeger R.G.2007ITGA6
16Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion. (17982624)Shang J.... Wei Q.2007NCAM1
17Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. (17113340)Greer R.O.... Weed S.A.2007CTTN
18Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes (17067458)Tian Z.... Li J.2006DNMT3B, DNMT1, RASSF1
19Effects of genistein on the expressions of cell cycle proteins in salivary adenoid cystic carcinoma cell line SACC-83 (16525614)Ma J.... Wang Z.Y.2006CDK4, CDK1
20Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands. (16094606)Nakashima D.... Tanzawa H.2006SERPINB5, STMN1
21Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma: expression patterns and effects on in vitro invasive behavior. (16546643)Wang L.... Li J.2006NTRK1, NGF
22Expression of galectin-3 in adenoid cystic carcinoma of the head and neck and its relationship with distant metastasis. (16184379)Teymoortash A.... Werner J.A.2006LGALS3, LGALS1
23p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. (15529180)Emanuel P.... Burstein D.E.2005TP63
24Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. (16243805)Zhang J.... Chen X.2005VEGFA, RELA, NOS2
25Effects of imatinib mesylate on adenoid cystic carcinomas. (16101197)Ochel H.J.... WAPrdehoff H.2005PDGFRB
26Immunohistochemical evaluation of p27 (kip1) in pleom orphic adenomas and adenoid cystic carcinomas of the minor salivary glands. (16436005)Shahsavari F.... Motahhary P.2005CDKN1B
27Adenoid glioblastoma arising in a patient with neurofibromatosis type-1. (15943792)Miyata S.... Kataoka H.2005S100B, GFAP
28Expression and significance of cyclin D1 in human adenoid cystic carcinoma (16078452)He W.... Li L.J.2005CCND1
29Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. (15153875)Edwards P.C.... Kelsch R.D.2004TP63
30c-kit expression in adenoid cystic carcinoma of the breast. (15370139)Hill P.A.2004KIT
31Cyclin D1 expression does not effect cell proliferation in adenoid cystic carcinoma of the salivary gland. (14714130)Yasumatsu R.... Yamamoto T.2004CCND1
32Mutations in components of the Wnt signaling pathway in adenoid cystic carcinoma. (15195113)Daa T.... Yokoyama S.2004AXIN1
33Urokinase-type plasminogen activator receptor expression in adenoid cystic carcinoma of the skull base. (12578452)Doerr T.D.... Elner V.2003PLAUR
34Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 cases. (14681328)Nagao T.... Lewis J.E.2003ERBB2
35C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma. (12738950)Edwards P.C.... Kelsch R.D.2003KIT, NTRK3
36High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid. (12149489)Zetterstrom C.K.... Boman H.G.2002HMGB1
37Overexpression of SCC antigen and cyclins in an adenoid squamous carcinoma cell line derived from the maxillary sinus. (11172595)Kishimoto H.... Furuyama J.I.2001SERPINB3, SERPINB4
38The effect of protein kinase C on the invasive behavior of human salivary adenoid cystic carcinoma in vitro (11831973)Sun C.... Wang Y.2000DYT10
39Apoptosis-induced and -suppressed cells in salivary g land adenoid cystic carcinoma: correlation with histological growth patterns. (10522207)Fujita S.... Tsuda N.1999DNTT
40Ultrastructural localization of E-cadherin and alpha-/beta-catenin in adenoid cystic carcinoma. (10583557)Shibuya Y.... Komori T.1999CDH1, CTNNA1
41Proliferating cell nuclear antigen and c-erbB-2 oncoprotein expression in adenoid cystic carcinomas of the salivary glands. (10402521)Cho K.J.... Lee Y.S.1999PCNA
42Adenoid cystic and adenoid basal carcinoma of the uterine cervix: comparative morphologic, mucin, and immunohistochemical profile of two rare neoplasms of putative 'reserve cell' origin. (10199475)Grayson W.... Cooper K.1999S100B, MUC1, CEACAM5
43Tumor necrosis factor alpha (TNF-alpha) activates hum an adenoidal and cutaneous mast cells to histamine secretion. (9419020)BrzeziA8ska-BA8aszczyk E.... Pietrzak A.1997TNF
44Adenoid basal carcinoma of the uterine cervix: immunohistochemical study and literature review. (9438010)Senzaki H.... Tsubura A.1997KRT14
45The role of p53 mutation and protein expression in primary and recurrent adenoid cystic carcinoma. (8666366)Papadaki H.... Kapadia S.B.1996TP53
46Estrogen and progesterone receptors in salivary gland adenoid cystic carcinoma. (8521108)Shick P.C.... Foss R.D.1995PGR
47Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study. (8669836)Shintani S.... Matsumura T.1995ERBB2, ERBB3
48The manifestation of proliferating cell nuclear antigen in adenoid cystic carcinoma. (7917205)Kim K.H.... Kim W.H.1994PCNA
49Immunohistochemical localization of estradiol, progesterone, and progesterone receptor in human salivary glands and salivary adenoid cystic carcinomas. (1322800)Ozono S.... Ito Y.1992PGR
50Expressions of oncogene products in adenoid cystic carcinomas of salivary glands: immunohistochemical study (1665502)Kusafuka K.1991ERBB2

Expression for genes affiliated with Adenoiditis

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Adenoiditis

Pathways for genes affiliated with Adenoiditis

about this section
Sources:
36QIAGEN, 10EMD Millipore, 20KEGG, 41Thomson Reuters, 3Cell Signaling Technology, 37R&D Systems
See all sources

Pathways related to adenoiditis according to GeneDecks:

(show top 50)    (show all 216)
idPathwayScoreTop Affiliating Genes
1Molecular Mechanisms of Cancer36INFBMP6, BIRC2, BIRC3, KDR, BCL2,
2Apoptosis and survival Role of CDK5 in neuronal death and survival1011.0BCL2, ERBB3, CYCS, NTRK1, NGF
3Pancreatic cancer2010.9CDK6
4Colorectal cancer2010.9AXIN1, MSH3, TGFB1
5Endometrial cancer2010.8PIK3CA, AXIN1, CDH1, MAPK3, MAPK1, CCND1
6Apoptosis and survival_Role of CDK5 in neuronal death and survival4110.8PIK3CA, BCL2, BAX, CDK1, MAPK3, MAPK1
7Small cell lung cancer2010.8PIK3CA, RELA, BIRC2, BIRC3, BCL2, CDK6
8Non-small cell lung cancer2010.7PIK3CA, RASSF1, CDK6, CDKN2A, CDK4, FHIT
9Prostate cancer2010.7PIK3CA, RELA, BCL2, CDKN1B, MDM2, MAPK3
10Glioma2010.6PIK3CA, CDK6, CDKN2A, CDK4, MDM2, MAPK3
11Melanoma2010.6PIK3CA, CDK6, CDKN2A, CDK4, CDH1, FGF2
12Glioblastoma Multiforme3610.6AXIN1, CDK6, CDKN1B, CDK4, MGMT, MDM2
13Breast Cancer Regulation by Stathmin13610.6FGF2, FGFR3, CCNB1, ERBB3, ERBB2, NTRK1
14Pathways in cancer2010.5PIK3CA, RELA, VEGFA, RASSF1, BIRC2, BIRC3
15Apoptosis and Autophagy310.4PIR, SERPINB5, BIRC2, BIRC3, BIRC5, BIRC7
16Rac1 Pathway3610.2BMP6, KDR, ITGA6, ITGAL, FGF2, FGFR3
17PTEN Pathway3610.0KIT, KDR, ITGA6, ITGAL, FGF2, FGFR3
18Angiogenesis39.9SERPINB5, KDR, ITGA6, MMP2, MMP7, MMP9
19DHA Signaling369.7KIT, BMP6, KDR, BCL2, BAX, FGF2
20Apoptotic Pathways in Synovial Fibroblasts369.7KIT, BMP6, KDR, FGF2, FGFR3, IL2
21PPAR Pathway369.6KIT, ITGA6, ITGAL, FGF2, FGFR3, IL2
22Bladder cancer209.3VEGFA, RASSF1, CDKN2A, CDK4, CDH1, MMP2
23Apoptosis209.3PIK3CA, RELA, BIRC2, BIRC3, BCL2, BAX
24Apoptosis Signaling Pathways379.1SFN, BIRC2, BIRC3, BIRC5, BIRC7, BCL2
25Colorectal Cancer Metastasis368.7BIRC5, BAX, MSH3, CDH1, MMP2, MMP7
26Toxoplasmosis208.5PIK3CA, RELA, BIRC2, BIRC3, BCL2, ITGA6
27PAK Pathway368.2KIT, BMP6, KDR, BCL2, BAX, FGF2
28Antioxidant Action of Vitamin-C367.5KIT, BMP6, KDR, BCL2, BAX, FGF2
29Tec Kinases Signaling366.9BMP6, BCL2, BAX, ITGA6, ITGAL, FGF2
30Mitochondrial Apoptosis36INFKIT, BMP6, BIRC2, KDR, BCL2,
31Rho Family GTPases36INFKIT, VIM, BMP6, KDR, BCL2, BAX
32Cellular Apoptosis Pathway36INFKIT, BMP6, BIRC2, KDR, BCL2,
33p53 Mediated Apoptosis36INFKIT, BMP6, KDR, BCL2, , BAX
34Paxillin Interactions36INFKIT, KDR, ITGA6, ITGAL, FGF2, FGFR3
35JAK-STAT Pathway36INFKIT, BMP6, KDR, BCL2, BAX, FGF2
36ERK Signaling36INFKIT, BMP6, ITGA6, ITGAL, FGFR3, IL1B
37NFAT in Immune Response36INFKIT, BMP6, KDR, CD79A, FGF2, FGFR3
38Akt Signaling36INFKIT, ITGA6, ITGAL, FGFR3, IL2, IL4
39Pancreatic Adenocarcinoma36INFKIT, BMP6, BIRC5, KDR, BCL2, CDKN2C
40MAPK Signaling36INFKIT, BMP6, KDR, BCL2, ITGA6, ITGAL
41p38 Signaling36INFKIT, BMP6, KDR, BCL2, BAX, FGF2
42GSK3 Signaling36INFKIT, BMP6, KDR, AXIN1, CDH12, CDH1
43Ras Pathway36INFKIT, KDR, ITGA6, FGF2, FGFR3, MAPK3
44Endothelin-1 Signaling Pathway36INFKIT, BMP6, FGFR3, IL1B, IL2, IL4
45p53 signaling pathway20INFSFN, SERPINB5, , BAX, CDK6, CDKN2A
46eNOS Signaling36INFKIT, BMP6, FGFR3, IL2, AQP1, HSPA4
47Estrogen Pathway36INFKIT, BMP6, KDR, BCL2, FGF2, FGFR3
48Nanog in Mammalian ESC Pluripotency36INFKIT, BMP6, KDR, AXIN1, FGF2, FGFR3
49ILK Signaling36INFKIT, VIM, KDR, CDH12, CDH1, FGF2
5014-3-3 Induced Intracellular Signaling36INFFGF2, FGFR3, MAPK3, MAPK1, AKT1, ERBB3

Compounds for genes affiliated with Adenoiditis

about this section
Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
See all sources

Compounds related to adenoiditis according to GeneDecks:

(show top 50)    (show all 412)
idCompoundScoreTop Affiliating Genes
1b 72332 11.1PCNA, VIM, CHKA, MUC1, MUC16, S100A1
2mucicarmine32 11.0VIM, MUC1, S100A1, S100B, CEACAM5, CEACAM7
3ionomycin32 10.9SERPINA3, CDK6, CDK4, FCER2, MAPK3, EZR
4crcs32 10.7PIK3CA, RASSF1, BIRC5, MUC1, CEACAM5, CDKN2A
5trastuzumab32 34 9 9 13.6PIK3CA, KIT, BIRC5, KDR, MUC1, CDK6
6bromodeoxyuridine32 10.5PIK3CA, NCAM1, PCNA, VIM, MYB, BMP6
7phosphotyrosine32 10.5PIK3CA, KIT, KDR, LGALS1, MUC5AC, CDKN3
8cetuximab32 34 9 9 13.4KDR, CDKN1B, CDKN3, ERBB3, EREG, ERBB2
9ganciclovir32 9 9 12.4VIM, BMP6, KDR, CEACAM3, CDKN3, CD9
10staurosporin32 10.2PIK3CA, BCL2, CDKN3, ITGAL, IL8, CASP3
11thymidylate32 10.1PCNA, VIM, VEGFA, BIRC5, BCL2, BAX
12depsipeptide32 10.0SERPINB5, BCL2, BAX, CDKN2A, CDH1, MMP2
13heparin32 9 18 9 13.0PIK3CA, NCAM1, SERPINA3, VIM, LGALS1, LGALS3
14retinoid32 10.0VIM, MYB, BMP6, LGALS1, MUC5AC, BAK1
15proline32 10.0PIN1, VIM, CLU, LGALS3, MUC5AC, S100B
16indole-3-carbinol32 9.9BIRC5, BCL2, BAX, CDK6, CDKN1B, CDK4
17noxa32 9.9BIRC5, BCL2, BAK1, BAX, MDM2, FAS
18tamoxifen32 34 9 9 12.8PIK3CA, PCNA, SERPINB5, VIM, VEGFA, VCAM1
19pge232 9.8VCAM1, MUC5AC, SAT1, CD14, CDH1, FGF2
20vinblastine32 9 9 11.8VIM, BIRC5, KDR, BCL2, BAX, CDK1
21dihydrotestosterone32 9 18 9 12.7VIM, BMP6, CLU, CHKA, CDK6, CD79A
22vitamin e succinate32 9.6VCAM1, BMP6, BCL2, BAX, CDKN3, FGF2
23carboplatin32 34 9 9 12.5VEGFA, KDR, BCL2, MUC16, CDK4, MGMT
24methionine32 9.5KIT, SERPINA3, VIM, MYB, RASSF1, LGALS1
25calcitriol32 42 9 18 9 13.4BMP6, CLU, BAK1, CDKN1B, CD14, CDK4
26p00232 9.4KIT, SERPINB5, BIRC5, CEACAM5, CD14, CD9
27thapsigargin32 42 10.3PCNA, MYB, BCL2, BAK1, CDKN3, ITGAL
28dmso32 9.2VIM, BMP6, MUC5AC, MMP7, HSPA4, PTK2B
293-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32 9.2PCNA, BCL2, BAK1, BAX, S100B, MMP2
30imatinib32 34 9 9 12.1PIK3CA, KIT, VEGFA, MYB, BMP6, BIRC5
31acetylcholine32 9 18 9 12.1NCAM1, SERPINA3, VIM, BMP6, CHKA, S100A1
325-aza-2deoxycytidine32 9.0PCNA, SERPINB5, VIM, BMP6, RASSF1, CLU
33diphenyleneiodonium32 8.5VEGFA, VCAM1, CDKN3, IL1B, IL8, MAPK3
34melphalan32 9 9 10.5BIRC5, MUC16, CD79A, MMP2, MGMT, FGFR3
35creatinine32 8.4NCAM1, PCNA, SERPINA3, VIM, BMP6, CHKA
36thalidomide32 42 9 9 10.9VEGFA, BIRC2, BIRC3, BIRC5, KDR, FGF2
37pdtc32 7.2PIK3CA, SERPINB5, VCAM1, BIRC3, BIRC5, BCL2
38herbimycin a32 42 7.6VCAM1, BMP6, CDK6, CD14, CDKN3, CDK4
39butyrate32 6.2PCNA, VIM, MYB, BMP6, BIRC5, CLU
40nitric oxide32 9 18 9 INF, NCAM1, KIT, SERPINB5, VCAM1, BMP6
41retinoic acid32 42 18 INFPIK3CA, NCAM1, KIT, VCAM1, MYB, BMP6
42genistein32 9 18 9 INFPIK3CA, PCNA, VIM, VEGFA, VCAM1, BIRC5
43glucose32 INFKIT, LGALS1, MUC16, BAK1, SAT1, S100B
4417-(allylamino)-17-demethoxygeldanamycin32 INFKIT, BIRC5, , CDK6, CDK4, CDH1
45wortmannin32 42 INFPIK3CA, VIM, VCAM1, BIRC2, BIRC5, KDR
46calcium32 9 18 9 INFPIN1, REG4, RELA, KIT, SFN, SERPINA3
47lipid32 INFPIK3CA, NCAM1, SERPINB5, SERPINA3, VIM, VCAM1
48nocodazole32 42 9 9 INFPIN1, VIM, BIRC5, , CD79A, CDKN3
49estrogen32 INF, PCNA, SERPINB5, SERPINA3, RASSF1, CLU
50okadaic acid32 42 INFPIK3CA, RELA, VIM, MYB, BMP6, BCL2

GO Terms for genes affiliated with Adenoiditis

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to adenoiditis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:005737INFTYMS, GFAP, ACTC1, ACP1, EGFR, KRT14
2cytosolGO:005829INFCTNNA1, MDM2, IL1B, , FHIT, CDK1
3integral to plasma membraneGO:005887INFICAM1, ERBB3, EREG, TNF, TNFSF10, SPN
4cell peripheryGO:07194410.7AXIN1, CTNNB1, NID1, KRT19, KRT14
5cell surfaceGO:0099869.1NTRK1, PLAUR, TIMP2, TGFA, TGFB1, CXCR4
6external side of plasma membraneGO:0098977.7CXCR4, NCAM1, KIT, VCAM1, CTLA4, SPN
7plasma membraneGO:0058866.7SPN, CTLA4, CTNNA1, CTNNB1, NTRK1, PTEN
8extracellular regionGO:0055766.4CTSD, CYR61, TNFSF10, EREG, HMGB1, GHRL
9extracellular spaceGO:005615INFADAM9, PECAM1, SOD1, TGFB1, TGFA, EGFR
10nucleusGO:005634INFPDGFRB, , AKT1, CASP8, CASP3, HSPA8

Biological processes related to adenoiditis according to GeneDecks:

(show top 50)    (show all 64)
idNameGO IDScoreTop Affiliating Genes
1regulation of cell proliferationGO:04212710.9EZH2, GHRL, ERBB3, NOS2, DNMT1, FAS
2G1/S transition of mitotic cell cycleGO:00008210.9CDK1, CCNB1, CCND1, SKP2, TYMS, CDK4
3activation of MAPKK activityGO:00018610.9ADAM9, NTRK1
4phosphatidylinositol-mediated signalingGO:04801510.9TOP2A, TYMS, PDGFRB, PDGFRA, NGF, NTRK1
5neuron apoptotic processGO:05140210.8TP63, TP53, ERBB3, CASP3, FAS, BAX
6positive regulation of cell migrationGO:03033510.7ADAM10, TGFB1, EGFR, PDGFRB, PDGFRA, SNAI2
7epidermal growth factor receptor signaling pathwayGO:00717310.6PTEN, EGF, EGFR, TGFA, TGFB1, PXN
8positive regulation of phosphatidylinositol 3-kinase activityGO:04355210.6TGFB1, PDGFRB, PDGFRA, PTK2B, FGFR3, FGF2
9Ras protein signal transductionGO:00726510.6NGF, NTRK1, TP53, MAPK1, MAPK3, FGF2
10cell proliferationGO:00828310.6ERBB2, TP53, PTEN, CYR61, SKP2, EGFR
11release of cytochrome c from mitochondriaGO:00183610.4TP53, CASP3, BAX, BAK1, BCL2, CLU
12induction of apoptosis by intracellular signalsGO:00862910.4CLU, BCL2, BAK1, BAX, CASP3, CASP8
13positive regulation of cell proliferationGO:00828410.4PTK2B, NGF, PDGFRA, PDGFRB, EGF, EGFR
14activation of pro-apoptotic gene productsGO:00863310.2TNFSF10, AKT1, CASP8, FAS, BAX, BAK1
15apoptotic DNA fragmentationGO:00630910.2SOD1, CYCS, HMGB1, CASP3, CDKN2A, BAX
16virus-host interactionGO:01904810.2CASP8, TP53, PDGFRA, KRT7, KRT19, TGFB1
17cellular response to organic substanceGO:07131010.0SYP, TIMP2, CASP3, IL1B, BAX, BCL2
18response to ethanolGO:04547110.0ICAM1, CASP8, ACTC1, SOD1, CCND1, IL4
19cellular response to mechanical stimulusGO:0712609.8TLR8, TLR7, CASP8, MAPK3, FAS, AQP1
20positive regulation of protein phosphorylationGO:0019349.8TGFB1, CYR61, TNF, ERBB2, AKT1, CCND1
21response to estradiol stimulusGO:0323559.7TGFB1, CTNNB1, PTGS2, ESR1, CASP8, ENO2
22positive regulation of MAP kinase activityGO:0434069.7EGFR, EGF, PDGFRB, TNF, ERBB2, VEGFA
23cellular response to organic cyclic compoundGO:0714079.7TGFB1, CTNNB1, TNF, IL1B, MGMT, ITGA6
24positive regulation of ERK1 and ERK2 cascadeGO:0703749.5PDGFRB, PDGFRA, NTRK1, PTK2B, TNF, MAPK3
25negative regulation of transcription, DNA-dependentGO:0458929.5ID1, HSPA8, EZH2, EREG, TP53, TP63
26induction of apoptosis by extracellular signalsGO:0086249.4NGF, SPN, DAPK1, TNFSF10, TNF, CASP8
27MAPK cascadeGO:0001659.1TGFB1, TGFA, EGFR, TNF, CCR5, MAPK1
28positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1NGF, PTEN, TNF, ESR1, AKT1, IL4
29signal transductionGO:0071659.1ERBB3, ERBB2, TNFSF10, PTK2B, SPN, PLAUR
30activation of MAPK activityGO:0001879.0FGF2, IL1B, MAPK3, MAPK1, GHRL, TNF
31cellular response to lipopolysaccharideGO:0712228.9ADAM9, NOS2, TNFAIP3, ICAM1, IFNG, CCR5
32anti-apoptosisGO:0069168.9CDK1, IL1B, IL2, FAS, AKT1, GHRL
33positive regulation of nitric oxide biosynthetic processGO:0454298.7EGFR, PTGS2, TNF, ESR1, AKT1, ICAM1
34response to drugGO:0424938.6TNF, PTGS2, CTNNB1, NGF, ACTC1, TOP2A
35inflammatory responseGO:0069548.3TNF, TNFAIP3, PTGS2, NGF, TLR7, TLR8
36positive regulation of apoptotic processGO:0430658.0FAS, IL1B, MMP9, ITGA6, BAX, BAK1
37response to DNA damage stimulusGO:006974INFTOP2A, CTLA4, TP53, CASP3, CCND1, MAPK3
38cell cycle arrestGO:007050INFTGFB1, TP53, IFNG, IL8, , CDKN3
39negative regulation of cell proliferationGO:008285INFSOX4, TGFB1, TIMP2, NTRK1, CDKN2A, CDKN1B
40peptidyl-tyrosine phosphorylationGO:018108INF, EGF, PDGFRB, PDGFRA, PTK2B, FGFR3
41blood coagulationGO:007596INFTP53, SPN, PLAUR, NOS2, EGF, TIMP1
42innate immune responseGO:045087INFCASP8, HMGB1, TNFAIP3, , TLR7, TLR8
43protein autophosphorylationGO:046777INFEGFR, PDGFRB, PDGFRA, NTRK1, DAPK1, PTK2B
44positive regulation of transcription, DNA-dependentGO:045893INFTP53, TP63, TNF, CTNNB1, SNAI1, EGF
45apoptotic processGO:006915INFSFN, IL1B, FAS, MAPK3, MAPK1, IFNG
46induction of apoptosisGO:006917INFPTEN, DAPK1, , WWOX, TIA1, TGFB1
47negative regulation of apoptotic processGO:043066INFCDKN1B, ITGA6, IL4, AQP1, MDM2, CASP3
48positive regulation of transcription from RNA polymerase II promoterGO:045944INFTNF, TP63, TP53, HMGB1, ESR1, CYR61
49wound healingGO:042060INFTGFA, PDGFRA, ERBB2, EREG, ERBB3, IL1B
50angiogenesisGO:001525INFEREG, PTEN, NRP2, EGF, TGFA,

Molecular functions related to adenoiditis according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:005515INFID1, TNFAIP3, TNFSF10, TERT, PTEN, PTK2B
2transmembrane receptor protein tyrosine kinase activityGO:00471410.6EGFR, PDGFRA, NTRK3, NTRK1, ERBB2, ERBB3
3integrin bindingGO:00517810.4ADAM9, ADAM10, TIMP2, GFAP, CYR61, ICAM1
4enzyme bindingGO:01989910.3PTGS2, CTNNB1, PLAUR, WWOX, EGFR, TOP2A
5identical protein bindingGO:0428029.9FAS, CASP8, AKT1, ESR1, ERBB2, TP53
6growth factor activityGO:0080839.2TGFA, EGF, NGF, EREG, IL4, IL2
7protein tyrosine kinase activityGO:004713INF, EGFR, PDGFRB, PTK2B, ERBB2, ERBB3
8protein homodimerization activityGO:042803INFNOS2, NTRK1, PTGS2, TERT, ERBB3, PDGFRA
9ATP bindingGO:005524INFPKM, NTRK3, NTRK1, DAPK1, PTK2B, TP53
10protein heterodimerization activityGO:046982INFERBB3, ERBB2, TP53, EGFR, TOP2A, TGFB1

Sources for Adenoiditis

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z