Adenoma malady

Disease Ontology: A cell type benign neoplasm that is composed of epithelial tissue in which tumor cells form glands or glandlike structures.⁶

MalaCards: Adenoma, also known as acinar cell adenoma, is related to carcinoma and prostatitis. An important gene associated with Adenoma is PLAG1 (pleiomorphic adenoma gene 1), and among its related pathways are Transendothelial Migration of Leukocytes and Pathways in cancer. The drugs octreotide acetate and octreotide and the compounds nadph and ethanol have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are skeleton and cellular.

Wikipedia: An adenoma is a benign tumor (-oma) of glandular origin. Adenomas can grow from many organs including...⁴⁴ more...

Aliases & Descriptions:

adenoma 6 7 8 32 43 acinar cell adenoma 6 43 adenomas 6 7

acinar cell adenoma (morphologic abnormality) 6 acinic cell adenoma 6

Diseases related to adenoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1049)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	163.8	ZNF410, PIK3CA, PIM3, KLF4, NCAM1, NCF2
2	prostatitis	139.1	PIK3CA, KLF4, NCAM1, NCOA1, NCOR1, NCOR2
3	adenocarcinoma	134.8	PIK3CA, PIM3, LRMP, KLF4, NCAM1, NCOA1
4	thyroiditis	131.0	ZNF331, PIK3CA, KLF4, NCAM1, NCOA1, NCOR1
5	pancreatitis	130.0	PIK3CA, PIM3, KLF4, NCAM1, NCF2, PDE4A
6	neuronitis	127.6	PIK3CA, KLF4, NCAM1, NCF2, NCOA1, NCOR1
7	leukemia	117.5	PIK3CA, KLF4, NCAM1, NCF2, NCOA1, NCOR1
8	pituitary adenoma	116.6	ZNF432, LRIG3, NCAM1, RECK, REG1A, REG1B
9	colon cancer	103.4	PIK3CA, PIM3, KLF4, NCAM1, NCOR2, PDCD4
10	gastric cancer	102.9	PIK3CA, KLF4, PDCD4, RECK, REG1A, REG3A
11	neuroblastoma	87.9	PIK3CA, KLF4, NCAM1, NCF2, NCOA1, NCOR2
12	hypoxia	86.6	PIK3CA, NCOA1, PDCD4, PDE4A, RECK, REN
13	sarcoma	84.5	PIK3CA, NCAM1, NCOA1, PDE4A, RECK, REN
14	ovarian carcinoma	80.8	PIK3CA, PDCD4, RECK, KIT, KISS1, KISS1R
15	cholesterol	79.8	PIK3CA, NCF2, NCOA1, NCOR1, NCOR2, RECK
16	hypertension	79.0	NCAM1, PDE4A, REN, RET, RETN, CNR1
17	alzheimer's disease	76.6	PIK3CA, NCAM1, NCF2, PDCD4, PDE4A, RECK
18	lung carcinoma	76.1	PIK3CA, NCAM1, RECK, PCNA, RB1, SETD2
19	obesity	74.2	PIK3CA, NCOR2, RECK, REG3A, REN, RETN
20	colon carcinoma	74.1	PIK3CA, KLF4, NCAM1, PDCD4, CNR1, KIT
21	retinitis	71.7	PIK3CA, PDE4A, CNR1, CNTF, CNTFR, KIT
22	astrocytoma	71.5	PIK3CA, NCAM1, RECK, RET, CNR1, KIT
23	meningioma	70.3	NCAM1, NCF2, RET, SFRP1, PCNA, RB1
24	diabetes mellitus	68.0	PIK3CA, PDE4A, RECK, REG1A, REG1B, REN
25	myeloma	67.7	PIK3CA, NCAM1, NCOR2, PDE4A, RECK, CNTF
26	polyposis	64.8	KLF4, RET, KITLG, SFRP1, PCNA, RB1
27	melanoma	64.4	PIK3CA, NCAM1, PDE4A, RECK, RET, CNC
28	hepatocellular carcinoma	63.8	PIK3CA, PIM3, NCAM1, PDCD4, RECK, REG1A
29	thyroid carcinoma	63.8	PIK3CA, RET, KITLG, PCNA, RB1, VIM
30	retinoblastoma	63.7	PIK3CA, NCAM1, RECK, KIT, KITLG, PCNA
31	multiple myeloma	61.6	PIK3CA, NCAM1, NCOR2, RECK, CNTF, KIT
32	esophagitis	61.6	ZNF410, PIK3CA, LRMP, KLF4, NCAM1, PDCD4
33	pheochromocytoma	59.5	NCAM1, REN, RET, KIT, PCSK2, PCSK1
34	insulin resistance	58.5	PIK3CA, REN, RETN, CNR1, CNTF, KISS1
35	breast carcinoma	58.3	PIK3CA, NCOR1, RECK, KIT, KISS1, KITLG
36	renal cell carcinoma	58.0	PIK3CA, RET, KIT, KISS1, KISS1R, SFRP1
37	endometriosis	57.6	PIK3CA, NCOA1, NCOR1, NCOR2, CNTF, KITLG
38	cervicitis	56.9	PIK3CA, PDCD4, PDE4A, RECK, REN, RET
39	aldosteronism	55.0	PIK3CA, REN, RETN, KISS1, KISS1R, SFRP1
40	familial adenomatous polyposis	55.0	KLF4, PCNA, RB1, VIM, NAT1, NAT2
41	colon adenocarcinoma	54.9	KLF4, REG4, VIP, BSG, BRCA1, VEGFA
42	endometrial adenocarcinoma	53.0	PIK3CA, KIT, PCNA, RB1, VIM, BRAF
43	hyperparathyroidism	52.5	RET, KITLG, PCNA, GCM2, VIP, VIPR1
44	pituitary tumor	51.7	NCAM1, CNC, PCSK2, PCSK1, RB1, VIP
45	wilms tumor	50.6	ZNF331, NCAM1, REN, RET, PCNA, SETD2
46	blindness	50.6	PDE4A, REN, CNR1, CNTF, GCG, SERPINA7
47	duodenitis	50.3	REG3A, KIT, KITLG, PCNA, GCK, GCG
48	acromegaly	49.7	RETN, CNC, GCG, VIP, VEGFA, PBX1
49	arthritis	49.5	PDE4A, RECK, RETN, CNR1, CNTF, KIT
50	colorectal adenoma and carcinoma	49.3	KLF4, RETN, PCNA, VEGFA, BCL2, BCL9L

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 octreotide, octreotide acetate

MalaCards organs/tissues related to adenoma:

²²

MGI Mouse Phenotypes related to adenoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	INF	NCOA1, RECK, SGPL1, CNR1, KIT, KITLG
2	cellular phenotype	MP:0005384	INF	PIK3CA, PIM3, KLF4, NCAM1, NCOR1, NCOR2
3	growth/size phenotype	MP:0005378	INF	PIK3CA, PIM3, NCOA1, NCOR1, NCOR2, RECK
4	pigmentation phenotype	MP:0001186	INF	KIT, KITLG, RB1, BRAF, BRCA1, MYC
5	hearing/vestibular/ear phenotype	MP:0005377	INF	LRIG3, KIT, KITLG, RB1, VDR, MYC
6	integument phenotype	MP:0010771	INF	KLF4, NCOA1, NCOR1, RECK, CNR1, KIT
7	embryogenesis phenotype	MP:0005380	INF	PIK3CA, NCOA1, NCOR1, RECK, RET, KIT
8	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, LRIG3, KLF4, NCAM1, NCOA1, NCOR1
9	liver/biliary system phenotype	MP:0005370	INF	NCOR1, NCOR2, RECK, REG1B, RETN, KIT
10	cardiovascular system phenotype	MP:0005385	INF	PIK3CA, NCOR2, PDE4A, RECK, REN, RET
11	tumorigenesis	MP:0002006	INF	PIK3CA, KLF4, PDCD4, RET, KIT, KITLG
12	vision/eye phenotype	MP:0005391	INF	PIK3CA, NCAM1, KIT, KITLG, SFTPC, RB1
13	digestive/alimentary phenotype	MP:0005381	INF	KLF4, NCOR2, RET, SGPL1, KIT, KISS1
14	renal/urinary system phenotype	MP:0005367	INF	NCOA1, PDCD4, REN, RET, SGPL1, KIT
15	limbs/digits/tail phenotype	MP:0005371	INF	RECK, RET, KIT, KITLG, SFRP1, RB1
16	no phenotypic analysis	MP:0003012	21.6	RET, CNR1, SFRP1, SFTPC, PCNA, RB1
17	respiratory system phenotype	MP:0005388	17.3	RET, SGPL1, SFTPC, BRCA1, BMPR1A, BMPR2
18	nervous system phenotype	MP:0003631	INF	NCOA1, NCOR1, PDE11A, PDE4A, RECK, REG1B
19	hematopoietic system phenotype	MP:0005397	INF	PIM3, SGPL1, CNTF, KIT, KISS1R, SFRP1
20	reproductive system phenotype	MP:0005389	INF	PIK3CA, KLF4, NCOA1, PDCD4, REG1A, REN
21	endocrine/exocrine gland phenotype	MP:0005379	INF	KLF4, NCOA1, PDCD4, REG1A, RET, SGPL1
22	muscle phenotype	MP:0005369	INF	PIK3CA, NCOR1, REN, RET, SGPL1, CNTF
23	craniofacial phenotype	MP:0005382	INF	LRIG3, KLF4, NCOR2, SGPL1, KIT, KITLG
24	immune system phenotype	MP:0005387	INF	PIM3, NCOA1, NCOR1, PDCD4, PDE4A, REN
25	adipose tissue phenotype	MP:0005375	INF	PIK3CA, NCOR1, NCOR2, RETN, CNR1, SFRP1
26	mortality/aging	MP:0010768	INF	PIK3CA, KLF4, NCAM1, NCOR1, NCOR2, PDCD4
27	normal phenotype	MP:0002873	INF	PIM3, KLF4, REN, RET, KISS1R, VIL1
28	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CA, KLF4, NCOA1, NCOR1, NCOR2, REG1A
29	other phenotype	MP:0005395	INF	RECK, CNR1, RARA, RARB, CLU, PBX1

Articles related to adenoma:

(show top 50)    (show all 2317)

id	Title	Authors	Year	Affiliating Genes
1	Tubular adenomas with minor villous changes show mole cular features characteristic of tubulovillous adenomas. (21263241)	Ishii T.... Whitehall V.	2011	TP53, KRAS, MGMT
2	Expression of CD44V6 in parotid pleomorphic adenoma a nd carcinoma ex pleomorphic adenoma. (20374021)	Yang S.... Chow L.W.	2010	CD44
3	Identification of histologically distinct conventiona l adenomas that arise predominately in patients with sessile serrated adenomas. (20118768)	Pai R.K.... Hart J.	2010	BRAF, KRAS
4	Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations. (19950209)	Gedlicka C.... Thurnher D.	2010	TP53
5	Increased expression levels of tensin3 mRNA in thyroi d functional adenomas as compared to non-functioning adenomas. (18561090)	Maeda I.... Hidaka Y.	2009	TNS3
6	Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. (18230181)	Kawasaki T.... Ogino S.	2008	PTGS2
7	Early carcinogenic events in HNPCC adenomas: differences with sporadic adenomas. (17999188)	Rijcken F.E.... Hollema H.	2008	BCL2, BAX, CCNB1
8	A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. (17889454)	Drieschner N.... Nimzyk R.	2007	THADA
9	Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland. (17593077)	Patel R.S.... O'Brien C.J.	2007	CCNA2
10	Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas. (17143260)	Takahashi T.... Shinomura Y.	2007	BRAF, MLH1, CDKN2A
11	Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland. (17927591)	Patel R.S.... O'Brien C.J.	2007	CCND1, CDKN2A
12	Immunolocalization of beta-catenin in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. (17721271)	Genelhu M.C.... Cassali G.D.	2007	CTNNB1
13	Immunohistochemical expression of p63 in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. (16256413)	Genelhu M.C.... Cassali G.D.	2006	TP63
14	DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. (16152625)	Wynter C.V.... Jass J.R.	2006	MLH1, CDKN2A, MGMT
15	Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias. (16931959)	Gill A.J.... Marsh D.J.	2006	CDC73
16	TRAIL induces apoptosis in human colorectal adenoma cell lines and human colorectal adenomas. (16857810)	Jalving M.... Kleibeuker J.H.	2006	CASP8, TNFSF10
17	Proliferating cell nuclear antigen (PCNA) expression in pituitary adenomas: relationship to the endocrine phenotype of adenoma. (16584090)	Pawlikowski M.... Radek A.	2006	PCNA
18	Sessile serrated adenomas of the large bowel. Clinicopathologic and immunohistochemical study including comparison with common hyperplastic polyps and adenomas. (16955561)	ChlumskA! A.... ZA!mecnA-k M.	2006	MUC2
19	PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. (15920557)	Martins C.... Soares J.	2005	PLAG1
20	Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor. (15173951)	Thodou E.... Kovacs K.	2004	PRL, SYP
21	Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence. (15595643)	Sasaki S.... Nagawa H.	2004	RNF34
22	Different apoptotic activity and p21(WAF1/CIP1), but not p27(Kip1), expression in serrated adenomas as compared with traditional adenomas and hyperplastic polyps of the colorectum. (12884030)	Mitomi H.... Otani Y.	2003	CDKN1A
23	Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. (12839979)	Preston S.L.... Wright N.A.	2003	CTNNB1
24	Differentiated papillary kidney tumors. Differentiation between metanephric adenoma and papillary adenoma (12185784)	Lugli A.... Moch H.	2002	VIM, KRT7
25	Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas. (12165656)	Kobayashi I.... Kameya T.	2002	NR5A1, GHRHR, POU1F1
26	Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma. (11812942)	Yantiss R.K.... Odze R.D.	2002	CDH1, TP53, MMP1
27	Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. (11555676)	Debiec-Rychter M.... Voz M.L.	2001	VIM, PLAG1
28	Immunohistochemical aspects of basal cell adenoma and canalicular adenoma of salivary glands. (11337269)	Machado de Sousa S.O.... Cavalcanti de AraA_jo V.	2001	VIM
29	Undefined complications of parathyroid adenoma, parathyroid hyperplasia (primary hyperparathyroidism), thyroid follicular adenoma, thyroid papillary carcinoma, temporal astrocytoma, cerebellar meningioma, and hemangioma of external auditory meatus and oral papilloma. (11030206)	Yamakita N.... Kitada M.	2000	RET, MEN1
30	Decreased expression of the gut-enriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients. (10913614)	Dang D.T.... Yang V.W.	2000	KLF4
31	Immunohistochemical analysis of pericryptal fibroblast sheath and proliferating epithelial cells in human colorectal adenomas and carcinomas with adenoma components. (10417686)	Li A.... Sato E.	1999	MKI67
32	Tissue factor expressed in pituitary adenoma cells contributes to the development of vascular events in pituitary adenomas. (10506725)	Nishi T.... Ushio Y.	1999	F3
33	Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. (10197610)	Samowitz W.S.... Slattery M.L.	1999	CTNNB1
34	Expression of P27kip1 and Ki-67 in pituitary adenomas: an investigation of marker of adenoma invasiveness. (10189502)	Zhao D.... Nose T.	1999	CDKN1B, MKI67
35	Quantitative analysis of growth-related factors in human pituitary adenomas. Lowered insulin-like growth factor-I and its receptor mRNA in growth hormone-producing adenomas. (10498342)	Otsuka F.... Makino H.	1999	IGF1, IGF2, POU1F1
36	Adenoma and tiny carcinoma in adenoma of the papilla of Vater--p53 and PCNA. (10430377)	Sato T.... Miwa A.	1999	TP53, PCNA
37	A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture. (8890999)	Matsuno A.... Kirino T.	1996	PRL, CGA, GH1
38	p53 expression patterns in colorectal adenomas and early carcinomas: a special reference to depressed adenoma and non-polypoid carcinoma. (9110348)	Yao T.... Tsuneyoshi M.	1996	TP53
39	p53 overexpression in flat serrated adenomas and flat tubular adenomas of the colorectal mucosa. (7559739)	Rubio C.A.... RodensjAP M.	1995	TP53
40	Proliferative activity in colonic adenomas as a predictor of metachronous adenomas as assessed by proliferating cell nuclear antigen immunohistochemistry. (7717318)	Paspatis G.A.... Hadziyannis S.J.	1995	PCNA
41	Detection of growth hormone, prolactin and human beta-chorionic gonadotropin mRNA in growth hormone-secreting pituitary adenomas and in prolactin-secreting pituitary adenomas by in situ hybridization using a non-isotopic detection method. (8317187)	Tallen G.... LA1decke D.K.	1993	PRL, GH1, CGB
42	Identification of gonadotroph adenomas in men with clinically nonfunctioning adenomas by the luteinizing hormone beta subunit response to thyrotropin-releasing hormone. (8077332)	Daneshdoost L.... Snyder P.J.	1993	GH1
43	Basic fibroblastic growth factor stimulates prolactin secretion from human anterior pituitary adenomas without affecting adenoma cell proliferation. (8370706)	Atkin S.L.... White M.C.	1993	FGF2, PRL, GH1
44	New technique for quantitation of pituitary adenoma s ize: use in evaluating treatment of gonadotroph adenomas with a gonadotropin-re leasing hormone antagonist. (8496331)	McGrath G.A.... Snyder P.J.	1993	GNRH1
45	Prolactin-containing pituitary adenomas. Their characteristics and comparative study with non-prolactin adenomas. (1625993)	Ho D.M.... Liu H.C.	1992	PRL
46	Analysis of pituitary hormones and chromogranin A mRNAs in null cell adenomas, oncocytomas, and gonadotroph adenomas by in situ hybridization. (1653518)	Lloyd R.V.... Kovacs K.	1991	POMC, GH1
47	Immunohistochemical study of monomorphic adenoma (clear cell and basal cell) and pleomorphic adenoma of the parotid gland (1897371)	Ramponi A.... Pia F.	1991	S100B, MUC1
48	Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta. (1886718)	Manning A.M.... Paraskeva C.	1991	BMP6
49	Comparison of long term results between prolactin secreting adenomas and ACTH secreting adenomas. (2155694)	Post K.D.... Habas J.E.	1990	PRL
50	Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells. (1699960)	Kuzuya N.... Yamashita K.	1990	TRH

Genes related to adenoma according to GeneCards:

(show top 50)    (show all 989)

id	Symbol	Description	Score	GeneCards Section Context
1	PLAG1	pleiomorphic adenoma gene 1	11.1	Functions, Summaries, Publications, Transcripts (show all 7 sections) Expressions, Aliases & Descriptions, Orthologs
2	PLAGL2	pleiomorphic adenoma gene-like 2	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs (show all 5 sections) Summaries
3	LIFR	leukemia inhibitory factor receptor alpha	11.1	Summaries, Publications
4	PLAGL1	pleiomorphic adenoma gene-like 1	11.1	Transcripts, Publications, Aliases & Descriptions, Functions (show all 5 sections) Orthologs
5	THADA	thyroid adenoma associated	11.0	Publications, Transcripts, Aliases & Descriptions, Proteins (show all 5 sections) Orthologs
6	DIO2	deiodinase, iodothyronine, type II	11.0	Publications, Summaries
7	LHCGR	luteinizing hormone/choriogonadotropin receptor	11.0	Publications, Summaries
8	HNF1A	HNF1 homeobox A	11.0	Publications, Summaries
9	AVPR1B	arginine vasopressin receptor 1B	11.0	Summaries
10	PAX8	paired box 8	11.0	Publications, Summaries
11	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0	Publications, Summaries
12	ADCY1	adenylate cyclase 1 (brain)	11.0	Publications, Summaries
13	ADCY4	adenylate cyclase 4	11.0	Summaries
14	ADCY6	adenylate cyclase 6	11.0	Summaries
15	ADCY3	adenylate cyclase 3	11.0	Summaries
16	ADCY5	adenylate cyclase 5	11.0	Summaries
17	ADCY7	adenylate cyclase 7	11.0	Summaries
18	ADCY2	adenylate cyclase 2 (brain)	11.0	Summaries
19	ADCY8	adenylate cyclase 8 (brain)	11.0	Summaries
20	ADCY9	adenylate cyclase 9	11.0	Summaries
21	CRAC1	colorectal adenoma and carcinoma 1	11.0	Publications, Aliases & Descriptions
22	SLC26A3	solute carrier family 26, member 3	11.0	Publications, Aliases & Descriptions, UniProt Related
23	C18orf54	chromosome 18 open reading frame 54	11.0	Aliases & Descriptions
24	CASC1	cancer susceptibility candidate 1	11.0	Aliases & Descriptions, Orthologs
25	ZNF331	zinc finger protein 331	11.0	Publications, Aliases & Descriptions
26	LOC152845	pleiomorphic adenoma gene-like 2 pseudogene	11.0	Aliases & Descriptions
27	MEN1	multiple endocrine neoplasia I	11.0	Publications
28	APC	adenomatous polyposis coli	11.0	Publications
29	GNAS	GNAS complex locus	11.0	Publications
30	PRL	prolactin	11.0	Publications
31	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
32	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications
33	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
34	GH1	growth hormone 1	11.0	Publications
35	KRT7	keratin 7	11.0	Publications
36	POMC	proopiomelanocortin	11.0	Publications
37	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
38	PCNA	proliferating cell nuclear antigen	11.0	Publications
39	RET	ret proto-oncogene	11.0	Publications
40	AIP	aryl hydrocarbon receptor interacting protein	11.0	Publications
41	SST	somatostatin	11.0	Publications
42	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
43	MUC1	mucin 1, cell surface associated	11.0	Publications
44	VIM	vimentin	11.0	Publications
45	TG	thyroglobulin	11.0	Publications
46	CNC	Carney complex, multiple neoplasia and lentiginosis	11.0	Publications
47	SSTR5	somatostatin receptor 5	11.0	Publications
48	SSTR2	somatostatin receptor 2	11.0	Publications
49	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
50	HMGA2	high mobility group AT-hook 2	11.0	Publications

Pathways related to adenoma according to GeneDecks:

(show top 50)    (show all 190)

id	Pathway	Score	Top Affiliating Genes
1	Transendothelial Migration of Leukocytes36	INF	NCF2, MYH1, RAP1A, RAP1B, RAC1, CLDN4
2	Pathways in cancer20	22.6	PIK3CA, RET, RB1, VEGFA, VEGFB, VEGFC
3	Pancreatic Adenocarcinoma36	21.8	KIT, KITLG, RB1, BRAF, VEGFB, VEGFC
4	Intracellular Calcium Signaling36	19.7	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP3
5	Estrogen Pathway36	19.3	NCOA1, NCOR1, NCOR2, KIT, KITLG, BRAF
6	eNOS Signaling36	18.9	KIT, KITLG, BMP2, BMP3, BMP6, LIFR
7	Antioxidant Action of Vitamin-C36	18.6	NCF2, KIT, KITLG, VEGFB, VEGFC, MYH1
8	p70S6K Signaling36	17.9	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP3
9	Neuroactive ligand-receptor interaction20	17.9	CNR1, KISS1R, VIPR1, LPAR1, LHCGR, LEP
10	p53 Mediated Apoptosis36	17.6	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP3
11	NFAT in Immune Response36	17.5	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP3
12	Rac1 Pathway36	17.2	NCF2, KITLG, VEGFB, BMP3, BMP4, BMP6
13	Paxillin Interactions36	17.0	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP3
14	DHA Signaling36	16.8	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP3
15	Akt Signaling36	16.6	KIT, VEGFB, VEGFC, BMP2, BMP3, BMP4
16	eIF2 Pathway36	16.1	KIT, KITLG, BRAF, VEGFC, BMP3, BMP4
17	JNK Pathway36	16.1	KIT, KITLG, VEGFB, BMP2, BMP3, BMP4
18	Cell cycle20	16.1	PCNA, RB1, MYC, CHEK2, ATM, CDK6
19	Cytokine-cytokine receptor interaction20	15.8	CNTF, CNTFR, KIT, KITLG, VEGFA, VEGFB
20	P2Y Receptor Signaling36	15.5	KIT, BRAF, VEGFB, VEGFC, MYC, RAF1
21	Glioma Invasiveness36	15.4	KITLG, VEGFB, VEGFC, BMP2, BMP3, BMP4
22	Neuroscience3	14.9	NCAM1, NCF2, RET, VHL, KCNE1, S100B
23	Transcription Androgen Receptor nuclear signaling10	14.0	NCOA1, NCOR1, RAF1, SCAP, FZD6, CDKN1A
24	Gap junction20	13.9	LPAR1, RAF1, CDK1, GRB2, MAPK1, GNA11
25	Glioblastoma Multiforme36	13.9	RB1, BRAF, RAF1, RAC1, AXIN1, FZD6
26	Adenylate cyclase-activating neuropeptides10	13.8	GCG, VIPR1, UCN, MC2R, GPR182, GNAS
27	Actin Nucleation and Branching36	13.8	KIT, RAC1, LIFR, PAK4, KDR, AXL
28	Actin-Based Motility by Rho Family GTPases36	13.5	BMP3, BMP4, PAK4, ITGA6, ITGB4, GSN
29	Endothelin-1 Signaling Pathway36	13.5	KIT, BRAF, MYC, BMP2, BMP3, BMP4
30	Development Endothelin-1/EDNRA signaling10	13.5	PIK3CA, RAF1, RAC1, GSK3B, GRB2, MAPK8
31	Cell adhesion ECM remodeling10	13.3	VCAN, LAMC2, CD44, ITGA5, ITGB1, MMP1
32	Cell adhesion_ECM remodeling41	13.3	VCAN, LAMC2, CD44, ITGA5, ITGB1, MMP1
33	Renal cell carcinoma20	13.0	VHL, RAP1A, RAF1, RAP1B, RAC1, PAK4
34	p53 Signaling36	12.8	BRCA1, BCL2, CHEK2, UBD, UBC, BAX
35	Development_IGF-1 receptor signaling41	12.8	PIK3CA, MYC, RAF1, BCL2L1, MTOR, IRS1
36	Colorectal cancer20	12.6	BRAF, RAC1, AXIN1, AXIN2, MSH2, MSH6
37	Development Ligand-independent activation of ESR1 and ESR210	12.6	PIK3CA, NCOA1, IRS1, GRB2, MAPK1, CCND1
38	Transcription_PPAR Pathway41	12.2	PIK3CA, NCOA1, NCOR1, NCOR2, RAF1, XIAP
39	Glucocorticoid Receptor Signaling36	12.2	NCOA1, NCOR1, NCOR2, BMP2, BMP3, BMP4
40	Development_HGF signaling pathway41	12.1	PIK3CA, RAP1A, RAF1, RAC1, SDC1, JUN
41	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	11.8	VDR, BGLAP, CGA, JUN, CDX2, CDKN1C
42	Transcription Role of VDR in regulation of genes involved in osteoporosis10	11.7	VDR, BGLAP, CGA, JUN, CDX2, CDKN1C
43	Toxoplasmosis20	11.1	PIK3CA, BIRC2, BIRC3, BCL2, BCL2L1, LDLR
44	IL-6 Pathway36	11.1	BRAF, BMP2, BMP3, BMP4, BMP6, RAF1
45	Pancreatic cancer20	11.0	CDK6
46	all-trans-Retinoic Acid Signaling in Brain36	10.9	BMP2, BMP3, BMP4, BMP6, RARA, RARB
47	MIF Mediated Glucocorticoid Regulation36	10.5	BMP2, BMP3, BMP4, BMP6, LIF, BCL2
48	Chagas disease (American trypanosomiasis)20	10.5	PIK3CA, CFLAR, JUN, FOS, IL10, IL12A
49	MAPK Signaling36	INF	KIT, KITLG, BRAF, VEGFB, VEGFC, MYC
50	ERK Signaling36	INF	KIT, KITLG, BRAF, VEGFB, VEGFC, MYC

Compounds related to adenoma according to GeneDecks:

(show top 50)    (show all 508)

id	Compound	Score	Top Affiliating Genes
1	nadph32 18	INF	PIK3CA, GCK, , XRCC1, XPC, FMO3
2	ethanol32 34 9 18 9	INF	NCAM1, KITLG, SFTPC, RARB, BID, CLU
3	glutamate32	INF	PIK3CA, NCAM1, NCOA1, CNR1, PCNA, GCK
4	heparan sulfate32 18	INF	NCAM1, RET, VIM, BSG, VCAN, BMP2
5	superoxide32 18	INF	PIK3CA, NCF2, PDE4A, CNTF, KITLG, RB1
6	acth32	26.6	REN, PCSK2, PCSK1, SERPINA7, VIP, LIFR
7	matrigel32	23.1	PIK3CA, NCAM1, RB1, SERPINB5, VIM, BSG
8	fatty acid32	21.7	NCOA1, RECK, RETN, SFTPC, GCK, GCG
9	agar32	21.2	PIK3CA, RET, KITLG, RB1, VIM, BRAF
10	methionine32	18.9	RECK, RET, CNTF, KIT, SFTPC, VIM
11	rapamycin32 42	19.2	KIT, KITLG, GCG, RB1, VIM, BRAF
12	curcumin32	17.7	NAT1, VEGFA, MYC, RAF1, BID, BIRC2
13	progestin32	17.2	VIM, VEGFA, LIF, PAEP, KDR, LHCGR
14	carbon32	16.2	CNR1, PCNA, VDR, LDLR, MTHFR, MTR
15	adenine32 9 18 9	19.1	RET, SETD2, NAT1, NAT2, BRAF, BRCA1
16	ly29400232	15.7	PIK3CA, RET, RETN, GCK, GCG, VHL
17	irinotecan32 34 9 9	18.5	KIT, BRAF, VEGFA, PARP1, BCL2L1, UGT1A
18	clonidine32 9 9	17.4	REN, BGLAP, SCT, LEP, CHGA, CGA
19	sodium nitroprusside32	15.3	PDE4A, REN, PCNA, VIP, MYB, BMP6
20	sialic acid32	15.2	NCAM1, RECK, SERPINA7, CLU, PAEP, LGALS1
21	prednisolone32 9 9	16.5	KITLG, VIP, MYC, BMP6, BGLAP, MUC16
22	haloperidol32 34 9 9	17.5	REN, VIP, KCNH2, KCNJ5, CHGA, MMP1
23	raloxifene32 9 9	16.3	NCOA1, SERPINA7, VDR, BMP2, BGLAP, UGT1A1
24	mitomycin c32	13.8	PCNA, RB1, BRCA1, BIRC5, XRCC2, XRCC3
25	streptozotocin32	13.7	REG3A, GCK, GCG, VIM, RAF1, KDR
26	rifampicin32	13.6	NCOA1, SERPINA7, NAT2, UGT1A, UGT1A1, UGT1A6
27	steroidal32	13.5	CDK2, ARSH, AR, IGFBP2, IFI27, GNRH1
28	lanreotide32	13.3	CHGA, IGFBP1, IGFBP3, IGF1, F2RL1, GH1
29	vincristine32 34 9 9	15.9	NCAM1, RECK, KIT, CGB, MGMT, FGF2
30	ceramide32	12.8	PIK3CA, CNR1, RB1, RAF1, BID, PARK2
31	gsts32	12.8	KIT, NAT1, NAT2, MTHFR, XRCC1, S100B
32	4-hydroxytamoxifen32	12.7	NCOA1, NCOR1, NCOR2, BRCA1, MYC, CLU
33	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	12.7	PCNA, MYC, PARP1, BCL2, BCL2L1, BAK1
34	mnng32	12.7	PCNA, PARP1, CHEK2, MUC5AC, XRCC1, MSH2
35	deoxypyridinoline32	12.4	VDR, BGLAP, CD36, MMP3, IL11, IL6R
36	irbesartan32 9 9	14.3	REN, JUN, MMP9, CCL2, ALB, CA1
37	sp 60012532 42	12.2	BID, BIRC2, BIRC3, CDKN1A, MMP1, MMP13
38	c2ceramide32	10.1	PARP1, BCL2L1, BAX, JUN, IRS1, GSTA2
39	infliximab32 9 9	11.9	VEGFA, BGLAP, BAK1, MMP1, MMP3, FGF2
40	suramin32 9 9	INF	NCAM1, RECK, PCNA, VIP, VEGFA, BMP6
41	serine32	INF	PIK3CA, PIM3, NCAM1, NCOA1, PDE4A, RECK
42	phospholipid32	INF	PDE4A, SFTPC, LPAR1, CLU, KCNE1, KCNH2
43	sulfate32 18	INF	RECK, VCAN, BMP4, MUC1, MUC2, GUSB
44	ang ii32	INF	REN, VEGFA, CD36, MAPK8, MAPK10, MAPK1
45	pertussis32	INF	VIP, LPAR1, JUN, ITGB2, FOS, FGFR2
46	aspartate32	INF	RET, RETN, CNR1, PCNA, SERPINA7, VIM
47	phosphatidylcholine32	INF	CNR1, SFTPC, VIM, VIP, RAF1, RAC1
48	estrogen32	INF	NCOA1, NCOR1, NCOR2, RETN, KISS1, PCNA
49	acetaminophen32 34 9 18 9	INF	PCNA, GCG, NAT2, MYC, BCL2L1,
50	oxygen32 18	INF	NCF2, KITLG, SFTPC, GCK, RB1, SETD2

Cellular components related to adenoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	NCAM1, RECK, CNR1, CNTFR, KIT, KITLG
2	cytoplasm	GO:005737	INF	PIM3, NCF2, PDCD4, REG3A, KIT, KITLG
3	extracellular space	GO:005615	INF	REG3A, REN, CNTF, KIT, KITLG, SFRP1
4	nucleus	GO:005634	INF	ZNF331, ZNF410, ZNF131, ZNF138, ZNF708, ZNF432
5	nucleoplasm	GO:005654	21.9	NCOA1, NCOR1, NCOR2, PCNA, GCK, RB1
6	membrane	GO:016020	19.1	PDE4A, RECK, REN, PCSK2, VHL, VEGFA
7	cell surface	GO:009986	17.5	NCAM1, KISS1R, SFRP1, VEGFA, LPAR1, BMP2
8	perinuclear region of cytoplasm	GO:048471	16.2	PDE4A, PCSK1, BSPRY, CLU, PARK2, BAG1
9	secretory granule	GO:030141	13.5	PCSK2, PCSK1, GCK, GCG, VEGFA, RAB3B
10	cytosol	GO:005829	INF	PIK3CA, NCF2, PDCD4, PDE11A, PDE4A, CNTF
11	extracellular region	GO:005576	INF	NCAM1, REG1A, REG1B, REG4, RETN, KISS1
12	integral to plasma membrane	GO:005887	INF	LRMP, RET, CNR1, VIPR1, LPAR1, BMPR2

Biological processes related to adenoma according to GeneDecks:

(show top 50)    (show all 58)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription, DNA-dependent	GO:045892	INF	KLF4, PDCD4, SFRP1, RB1, RBM15, BRCA1
2	positive regulation of transcription, DNA-dependent	GO:045893	INF	KLF4, NCOA1, RET, SFRP1, RB1, BRCA1
3	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	KLF4, NCOR1, NCOR2, VHL, VDR, MYC
4	signal transduction	GO:007165	26.4	PDE11A, PDE4A, RET, CNTF, CNTFR, KIT
5	negative regulation of apoptotic process	GO:043066	19.7	PIM3, SFRP1, GCG, GCM2, BRAF, VEGFA
6	blood coagulation	GO:007596	19.1	PIK3CA, PDE11A, BSG, VEGFA, VEGFB, VEGFC
7	apoptotic process	GO:006915	18.4	PIM3, PDCD4, SGPL1, VIM, BRCA1, BOK
8	response to drug	GO:042493	18.0	NCF2, PDE4A, REN, SFRP1, PCSK1, SERPINA7
9	cell proliferation	GO:008283	17.3	REG1B, REG3A, KITLG, PCNA, GCG, BOK
10	cell-cell signaling	GO:007267	16.8	PCSK1, BMP2, BMP3, CGA, CGB, CEACAM6
11	G-protein coupled receptor signaling pathway	GO:007186	16.3	KISS1, KISS1R, GCG, VIP, VIPR1, LPAR1
12	platelet activation	GO:030168	15.8	PIK3CA, VEGFA, VEGFB, VEGFC, RAP1A, RAPGEF3
13	energy reserve metabolic process	GO:006112	15.7	PCSK1, GCG, MYC, RAP1A, RAPGEF3, RAP1B
14	cell surface receptor signaling pathway	GO:007166	15.4	BSG, LIFR, BIRC2, BIRC3, LEPR, BAG1
15	cell cycle arrest	GO:007050	14.9	RB1, MYC, RASSF1, MSH2, ATM, CDK6
16	xenobiotic metabolic process	GO:006805	14.9	NAT1, NAT2, UGT1A1, UGT1A6, MTR, FMO3
17	fibroblast growth factor receptor signaling pathway	GO:008543	14.7	PIK3CA, BRAF, RAF1, UBA52, UBC, MTOR
18	nerve growth factor receptor signaling pathway	GO:048011	14.6	PIK3CA, BRAF, RAP1A, RAF1, RAC1, BCL2L11
19	female pregnancy	GO:007565	14.6	CLDN4, BCL2, SCGB1A1, LEP, UCN, FSHB
20	anti-apoptosis	GO:006916	14.6	PIK3CA, BRAF, VHL, VEGFB, BIRC2, BIRC3
21	epidermal growth factor receptor signaling pathway	GO:007173	14.5	PIK3CA, VIL1, RAF1, UBA52, UBC, MTOR
22	transcription initiation from RNA polymerase II promoter	GO:006367	14.5	NCOR1, NCOR2, VDR, MYC, RARA, RARB
23	positive regulation of apoptotic process	GO:043065	14.4	NCOA1, CNR1, SFRP1, LPAR1, BMP2, BMP4
24	response to hypoxia	GO:001666	14.4	VEGFA, BMP2, RAF1, CLDN3, BCL2, SCAP
25	positive regulation of cell migration	GO:030335	14.3	RET, VIL1, VEGFA, BMP2, KDR, CGA
26	aging	GO:007568	14.2	NCF2, CNR1, SERPINA7, VDR, SCAP, BAK1
27	regulation of cell proliferation	GO:042127	14.1	KIT, BRCA1, BMPR2, BID, BIRC2, BIRC7
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	13.9	KITLG, VEGFA, VEGFB, LIF, MTOR, CD36
29	positive regulation of MAPK cascade	GO:043410	13.9	CNTF, KIT, LPAR1, LIF, KDR, LEP
30	male gonad development	GO:008584	13.6	REN, KIT, KITLG, SFRP1, BOK, BCL2
31	platelet degranulation	GO:002576	13.6	VEGFA, VEGFB, VEGFC, CLU, SCG3, CD36
32	response to organic cyclic compound	GO:014070	13.5	NCF2, SFRP1, BMP4, UGT1A1, BAK1, MSH2
33	transforming growth factor beta receptor signaling pathway	GO:007179	13.5	NCOR1, NCOR2, MYC, BMPR1A, PARP1, UBA52
34	response to estradiol stimulus	GO:032355	13.5	NCOA1, VDR, BMP4, RARA, BID, UCN
35	response to lipopolysaccharide	GO:032496	13.5	NCF2, CNR1, SFTPC, PCSK1, UGT1A1, S100A8
36	positive regulation of ERK1 and ERK2 cascade	GO:070374	13.2	GCG, BRAF, VEGFB, BMP2, BMP4, KDR
37	response to ethanol	GO:045471	13.1	CNR1, BGLAP, BCL2, BAK1, S100A8, CDK1
38	positive regulation of cell division	GO:051781	12.9	VEGFA, VEGFB, VEGFC, FIGF, FGF1, FGF2
39	positive regulation of protein phosphorylation	GO:001934	12.5	VEGFA, BMP2, BMP4, MT3, MTOR, AXIN1
40	inflammatory response	GO:006954	12.5	KIT, BMP2, BMP6, RAC1, SCG2, UCN
41	regulation of insulin secretion	GO:050796	12.0	CNR1, PCSK1, GCK, GCG, RAP1A, RAPGEF3
42	response to glucocorticoid stimulus	GO:051384	11.9	SFTPC, PCSK1, BGLAP, UCN, INSR, IL10
43	activation of MAPK activity	GO:000187	11.3	KIT, LPAR1, UBA52, UBC, CD74, CDK1
44	response to mechanical stimulus	GO:009612	10.9	BMP2, BMP4, BGLAP, JUN, MMP9, CCL2
45	positive regulation of cell proliferation	GO:008284	INF	REG1A, CNTF, CNTFR, KIT, SFRP1, VIP
46	angiogenesis	GO:001525	INF	PIK3CA, SETD2, VEGFA, VEGFC, RAPGEF3, KDR
47	negative regulation of cell proliferation	GO:008285	INF	KLF4, KISS1R, SFRP1, VHL, VDR, BMP2
48	positive regulation of endothelial cell proliferation	GO:001938	INF	VEGFA, VEGFB, BMP2, BMP4, BMP6, BMPR2
49	small molecule metabolic process	GO:044281	INF	PIK3CA, NCOA1, NCOR1, NCOR2, SGPL1, PCSK1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	KLF4, NCOA1, RB1, BRCA1, VEGFA, VDR

Molecular functions related to adenoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:020037	INF	, , MPO, CBS, CAT, TPO
2	sequence-specific DNA binding	GO:043565	INF	GCM2, VDR, MYC, RARA, RARB, PBX1
3	protein homodimerization activity	GO:042803	19.8	KIT, SFTPC, VIL1, VEGFA, VEGFB, BMP2
4	protein heterodimerization activity	GO:046982	16.3	BRAF, VEGFA, VEGFB, BOK, MYC, BMP2
5	receptor binding	GO:005102	16.2	REN, CNTFR, GCG, BMP2, BMP3, RARA
6	transcription factor binding	GO:008134	16.0	RB1, VHL, MYC, RARA, PBX1, PARP1
7	enzyme binding	GO:019899	16.0	NCOA1, BRCA1, VHL, RARA, RAC1, BIRC5
8	identical protein binding	GO:042802	15.9	VWA2, SFRP1, PCNA, VIL1, VIM, RAF1
9	hormone activity	GO:005179	15.6	RETN, GCG, VIP, SCT, LEP, CHGB
10	growth factor activity	GO:008083	15.2	REG1A, CNTF, KITLG, VEGFA, VEGFB, VEGFC
11	cytokine activity	GO:005125	11.7	CNTF, KITLG, VEGFA, BMP2, BMP3, BMP4
12	electron carrier activity	GO:009055	INF	NCF2, , , , FDX1, GPX2
13	protein binding	GO:005515	INF	PIK3CA, PIM3, NCF2, NCOA1, NCOR1, NCOR2
14	transcription regulatory region DNA binding	GO:044212	INF	KLF4, NCOR1, BRCA1, PAX8, PAX2, YY1