MCID: ADN018
MIFTS: 67

Adenoma malady

Summaries for Adenoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cell type benign neoplasm that is composed of epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards: Adenoma, also known as acinar cell adenoma, is related to pituitary adenoma and pleomorphic adenoma. An important gene associated with Adenoma is PLAGL1 (pleiomorphic adenoma gene-like 1), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Pancreatic secretion. The drugs octreotide and octreotide acetate and the compounds zinc and forskolin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and colon, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Wikipedia:63 An adenoma (adeno-, \"gland\" + -oma, \"tumor\") (/ˌædɨˈnoʊmə/; plural adenomas or adenomata... more...

Aliases & Classifications for Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

adenoma 8 10 44 60
acinar cell adenoma 8 60
acinic cell adenoma 8
adenomas 8


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Disease Ontology8 DOID:657
NCIt39 C2855
MeSH34 D000236

Related Diseases for Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 650)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma31.9LIFR
2pleomorphic adenoma31.6PLAGL2, PLAGL1, PLAG1
3adenocarcinoma31.2DIO2, PLAG1, SLC26A3, KRAS
4lung adenoma30.9CASC1, C18orf54
5follicular thyroid carcinoma30.8PAX8, DIO2
6pancreatitis30.8KRAS
7hyperthyroidism30.5DIO2
8thyroid cancer30.3DIO2, PAX8, ADCY1
9breast cancer30.1HNF1A, LHCGR, LIFR, PLAGL1, KRAS
10thyroid adenoma30.0DIO2
11parathyroid adenoma11.1
12thyroiditis11.0
13adrenal adenoma11.0
14papillary adenoma10.8
15pleomorphic adenoma carcinoma10.8
16pleomorphic carcinoma10.8
17nephrogenic adenoma10.8
18hepatitis10.8
19follicular adenoma10.8
20renal adenoma10.7
21functioning pituitary adenoma10.7
22hyperparathyroidism10.7
23colorectal cancer10.7
24growth hormone secreting pituitary adenoma10.7
25metanephric adenoma10.7
26chromophobe adenoma10.7
27prostatic adenoma10.7
28cushing's syndrome10.7
29primary hyperparathyroidism10.7
30prostatitis10.6
31papillary carcinoma10.6
32mediastinitis10.6
33familial adenomatous polyposis10.6
34microcystic adenoma10.6
35acromegaly10.6
36parathyroid carcinoma10.6
37sebaceous adenoma10.6
38hepatitis a10.6
39papillary thyroid carcinoma10.5
40apocrine adenoma10.5
41bile duct adenoma10.5
42clear cell adenoma10.5
43acth-secreting pituitary adenoma10.5
44pituitary apoplexy10.5
45breast adenoma10.5
46hyperaldosteronism10.5
47prolactinoma10.5
48pregnancy adenoma10.5
49hypertension10.4
50middle ear adenoma10.4

Graphical network of the top 20 diseases related to Adenoma:



Diseases related to adenoma

Clinical Features for Adenoma

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Drugs & Therapeutics for Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Adenoma

Drug clinical trials:

Search ClinicalTrials for Adenoma

Search NIH Clinical Center for Adenoma

Search CenterWatch for Adenoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Adenoma

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Anatomical Context for Adenoma

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32MalaCards
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MalaCards organs/tissues related to Adenoma:

32
Pituitary, Thyroid, Colon, Salivary gland, Prostate, Lung, Pancreas, Kidney, Liver, Bone, Adrenal gland, Breast, Testes, Endothelial, Cervix, Ovary, Trachea, Cortex, Adrenal cortex, Appendix, Skin, Tongue, Lymph node, Small intestine, Bone marrow, Smooth muscle, Placenta, Uterus, Testis, B cells, Thymus, Brain, Monocytes, Hypothalamus, T cells, Myeloid, Eye, Pons

Animal Models for Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.8KRAS, PAX8, ADCY6, SLC26A3, PLAGL2, AVPR1B
2MP:000537812.2PLAG1, LIFR, HNF1A, PAX8, DIO2, LHCGR
3MP:000538111.8LHCGR, DIO2, PLAGL2, SLC26A3, KRAS, ADCY7
4MP:000536711.6LHCGR, DIO2, KRAS, PAX8, ADCY6, HNF1A
5MP:000537911.5PLAG1, AVPR1B, PAX8, KRAS, HNF1A, LHCGR

Publications for Adenoma

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50PubMed
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Articles related to Adenoma:

(show top 50)    (show all 6144)
idTitleAuthorsYear
1
Expression and localization of osteopontin, homing cell adhesion molecule/CD44, and integrin I+vI^3 in pleomorphic adenoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. (24237725)
2013
2
Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification. (23691331)
2013
3
Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome. (24199207)
2013
4
Transoral carbon dioxide laser excision of an ectopic parathyroid adenoma from the hypopharynx. (23921498)
2013
5
Carcinoma ex pleomorphic adenoma of the sublingual gland: a case report. (22241374)
2012
6
Role of contrast-enhanced sonography in differentiation of subtypes of hepatocellular adenoma: correlation with MRI findings. (22826395)
2012
7
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1. (22564666)
2012
8
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. (20888068)
2011
9
Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans. (22022386)
2011
10
Intrasellar salivary gland-like pleomorphic adenoma: case report. (21135727)
2011
11
Wnt/I^-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors. (21084400)
2011
12
Pleomorphic adenoma of the palate. (23272462)
2011
13
Pituitary apoplexy: re-evaluation of risk factors for bleeding into pituitary adenomas and impact on outcome. (20926593)
2011
14
Association of vascular endothelial growth factor 936C/T polymorphism and the susceptibility to colorectal adenoma]. (20422487)
2010
15
A comparative study by age and gender of the pituitary adenoma and ACTH and alpha-MSH secretion in dogs with pituitary-dependent hyperadrenocorticism. (19683322)
2010
16
Cytological features of myxoid adrenocortical adenoma with a pseudoglandular component: a case report with differential diagnostic considerations. (18618725)
2008
17
Expressions and significance of STAT3 and p38 in the carcinogenesis of sporadic colorectal tubular adenoma]. (18069631)
2007
18
Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas. (17218727)
2007
19
Expression of survivin in colorectal adenoma and adenocarcinoma]. (17633470)
2007
20
Excision of postesophageal parathyroid adenoma in posterior mediastinum with intraoperative 99mTechnetium sestamibi scanning. (17954108)
2007
21
Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study. (16984249)
2006
22
An unusual somatotropin and thyreotropin secreting pituitary adenoma efficiently controlled by Octreotide and Pegvisomant. (16840917)
2006
23
Image in endocrinology: giant mediastinal cystic parathyroid adenoma. (16679508)
2006
24
Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology. (16804979)
2006
25
Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas. (16545110)
2006
26
Prevalence and incidence of hyperplastic polyps and adenomas in familial colorectal cancer: correlation between the two types of colon polyps. (12865272)
2003
27
Growth pituitary adenomas: evaluation of 20 patients]. (11965421)
2002
28
Spontaneous parathyroid adenoma hemorrhage. (12382409)
2002
29
Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. (12208673)
2002
30
Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenoma. (12433739)
2002
31
Combined primary aldosteronism and preclinical Cushing's syndrome: an unusual case presentation of adrenal adenoma. (11768734)
2001
32
Visual vignette. Hyperparathyroidism due to a parathyroid adenoma. (11441818)
2000
33
MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. (10064332)
1999
34
Localization of a parathyroid adenoma by the addition of pinhole imaging to Tc-99m sestamibi dual-phase scintigraphy. Report of a case and review of experience. (9031762)
1997
35
Spontaneous vocal cord paresis and return to normocalcemia: an unusual presentation of parathyroid adenoma with concomitant abscess. (9186472)
1997
36
In situ stromal expression of the urokinase/plasmin system correlates with epithelial dysplasia in colorectal adenomas. (9006343)
1997
37
Metanephric adenoma of the kidney: histologic, immunohistochemical and DNA content analysis study. A case report. (9269909)
1997
38
The results of p53 immunostaining in colorectal adenomas, early cancers, advanced cancers and their hepatic metastasis]. (8678561)
1996
39
Double pituitary adenoma--two case reports. (9420436)
1996
40
DNA ploidy and proliferating cell nuclear antigen in colonic adenomas and adenocarcinomas. (7729290)
1995
41
Overexpression of p53 protein and proliferative activity in colorectal adenoma. (7910956)
1994
42
High prolactin levels in patients with Cushing's disease without pathological evidence of pituitary adenoma. (8392915)
1993
43
Autonomously functioning thyroid adenoma in a seven year old boy. (1726908)
1991
44
Radiation-induced meningioma after treatment for pituitary adenoma: case report and literature review. (2407971)
1990
45
Testosterone-secreting adrenal adenoma in a peripubertal girl. (3312660)
1987
46
Hepatic ultrasonography in type I glycogen storage disease (von Gierke disease). Detection of hepatic adenoma and carcinoma. (6272355)
1981
47
Apparent "negative cooperativity" kinetics in the absence of a nonlinear Scatchard plot of thyrotropin-receptor interaction in a human thyroid adenoma. (6251807)
1980
48
Letter: Hepatocellular adenoma: relationship to oral contraceptives? (181604)
1976
49
Uncommon mediastinal tumors. Report of two parathyroid adenomas, one nonfunctional parathyroid carcinoma and one "bronchial-type-adenoma". (13940962)
1963
50
The human seminal vesicle. A morphogenetic and gross anatomic study with special regard to changes due to age and to prostatic adenoma. (14479899)
1962

Genetic Variations for Adenoma

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Expression for genes affiliated with Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoma

Search GEO for disease gene expression data for Adenoma.

Pathways for genes affiliated with Adenoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore, 49PharmGKB
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Pathways related to Adenoma according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.4AVPR1B, ADCY7, ADCY6, ADCY1, LHCGR
211.4ADCY1, SLC26A3, ADCY7, ADCY4, ADCY6
3
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11.4ADCY4, SLC26A3, ADCY1, ADCY6, ADCY7
4
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11.4ADCY6, ADCY1, ADCY4, ADCY7, LIFR
5
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11.4ADCY4, ADCY6, ADCY7, LIFR, ADCY1
6
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11.4ADCY7, ADCY4, ADCY1, ADCY6, LIFR
7
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11.4LIFR, ADCY4, ADCY7, ADCY6, ADCY1
811.4ADCY7, ADCY4, AVPR1B, LHCGR, ADCY1
911.4AVPR1B, ADCY6, ADCY1, ADCY4, ADCY7
10
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11.4ADCY7, ADCY4, ADCY6, ADCY1, LHCGR
1111.4ADCY4, ADCY1, ADCY6, ADCY7, LHCGR
12
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11.4ADCY7, KRAS, ADCY6, ADCY1, ADCY4
13
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11.4KRAS, ADCY7, ADCY6, ADCY4, ADCY1
14
Signal transduction cAMP signaling
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11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
15
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11.4ADCY6, ADCY4, ADCY1, ADCY7, KRAS
1611.4ADCY4, ADCY1, ADCY6, KRAS, ADCY7
1711.4ADCY7, KRAS, ADCY4, ADCY1, ADCY6
18
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11.4ADCY1, ADCY6, KRAS, ADCY4, ADCY7
19
Development Endothelin-1/EDNRA signaling
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11.4ADCY4, ADCY7, ADCY1, KRAS, ADCY6
20
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11.4KRAS, ADCY4, ADCY1, ADCY6, ADCY7
21
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11.4ADCY6, ADCY1, ADCY4, ADCY7, KRAS
22
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11.2ADCY1, ADCY6, ADCY7, PAX8
23
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11.2KRAS, ADCY7, ADCY1, ADCY6
24
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11.2ADCY6, ADCY4, ADCY7, ADCY1
25
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11.2ADCY4, ADCY1, ADCY6, ADCY7
2611.2ADCY1, ADCY7, ADCY4, ADCY6
27
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11.2ADCY6, ADCY1, ADCY4, ADCY7
2811.2ADCY4, ADCY7, ADCY1, ADCY6
29
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
11.2ADCY4, ADCY7, ADCY6, ADCY1
3011.2ADCY6, ADCY7, ADCY4, ADCY1
31
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11.2ADCY1, ADCY7, ADCY6, ADCY4
3211.2ADCY1, ADCY4, ADCY6, ADCY7
3311.2ADCY6, ADCY4, ADCY1, ADCY7
34
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11.2ADCY7, ADCY6, ADCY1, ADCY4
35
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11.2ADCY4, ADCY1, ADCY7, ADCY6
3611.2ADCY4, ADCY7, ADCY6, ADCY1
3711.2ADCY1, ADCY6, ADCY7, ADCY4
3811.2ADCY7, ADCY4, ADCY1, ADCY6
3911.2ADCY4, ADCY6, ADCY1, ADCY7
40
G-protein signaling G-Protein alpha-i signaling cascades
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11.2ADCY4, ADCY1, ADCY6, ADCY7
41
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11.2ADCY7, ADCY6, ADCY1, ADCY4
42
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11.2ADCY7, ADCY6, ADCY1, ADCY4
43
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11.0ADCY1, ADCY6, ADCY7
44
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11.0ADCY7, ADCY1, ADCY6
45
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11.0ADCY7, ADCY1, ADCY6
46
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10.8ADCY6, ADCY4
47
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10.8ADCY1, ADCY4
48
Hide members
10.8ADCY1, ADCY4

Compounds for genes affiliated with Adenoma

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Adenoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1zinc44 2412.7PLAGL2, HNF1A, PLAG1, PLAGL1, ZNF331, LIFR
2forskolin44 49 1113.6ADCY1, DIO2, LHCGR, PAX8, ADCY7
3nkh 4775911.5ADCY4, ADCY7, ADCY6, ADCY1
4pacap 1-275911.5ADCY6, ADCY1, ADCY4, ADCY7
5kh 75911.5ADCY7, ADCY6, ADCY1, ADCY4
6mdl 12330a hydrochloride5911.5ADCY4, ADCY1, ADCY6, ADCY7
7cyclic amp44 2412.5ADCY6, ADCY4, ADCY1, ADCY7, LHCGR
8sq 2253659 4412.5ADCY7, ADCY4, ADCY1, ADCY6
9Pyruvic acid11 2412.4ADCY6, ADCY1, ADCY7, ADCY4
10oligonucleotide4411.4PAX8, HNF1A, LIFR, PLAG1, KRAS
11acth4411.4ADCY1, LIFR, LHCGR, AVPR1B
12nad28 2412.3ADCY7, ADCY4, ADCY1, ADCY6
13phosphoric acid44 2412.2ADCY1, ADCY4, ADCY6, ADCY7
14pyrophosphate44 2412.1ADCY7, ADCY6, ADCY1, ADCY4
15nadh44 11 2412.9ADCY4, ADCY1, ADCY6, ADCY7

GO Terms for genes affiliated with Adenoma

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16Gene Ontology
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Biological processes related to Adenoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1activation of phospholipase C activityGO:00720211.7ADCY4, ADCY1, ADCY6, ADCY7, AVPR1B
2fibroblast growth factor receptor signaling pathwayGO:00854311.6KRAS, ADCY4, ADCY7, ADCY6, ADCY1
3epidermal growth factor receptor signaling pathwayGO:00717311.6ADCY7, KRAS, ADCY6, ADCY4, ADCY1
4neurotrophin TRK receptor signaling pathwayGO:04801111.5ADCY7, ADCY6, ADCY1, ADCY4, KRAS
5activation of protein kinase A activityGO:03419911.5ADCY7, ADCY4, ADCY1, ADCY6
6cellular response to glucagon stimulusGO:07137711.5ADCY7, ADCY4, ADCY1, ADCY6
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718911.5ADCY6, ADCY4, ADCY7, ADCY1
8water transportGO:00683311.5ADCY1, ADCY6, ADCY7, ADCY4
9adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719311.5ADCY4, ADCY1, ADCY6, ADCY7
10transmembrane transportGO:05508511.4ADCY4, ADCY7, ADCY1, SLC26A3, ADCY6
11energy reserve metabolic processGO:00611211.4ADCY4, ADCY1, ADCY6, ADCY7
12intracellular signal transductionGO:03555611.3ADCY6, ADCY4, ADCY7, ADCY1
13cAMP biosynthetic processGO:00617111.3ADCY6, ADCY1, ADCY4
14synaptic transmissionGO:00726811.2ADCY7, ADCY6, ADCY1, ADCY4
15innate immune responseGO:04508711.1ADCY1, ADCY4, ADCY7, ADCY6, KRAS
16cellular response to gonadotropin stimulusGO:07137110.7PAX8, LHCGR

Molecular functions related to Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:04687211.8PLAGL1, PLAGL2, ADCY7, ADCY6, ADCY1, ADCY4
2adenylate cyclase activityGO:00401610.7ADCY4, ADCY6, ADCY7

Products for genes affiliated with Adenoma

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Sources for Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet