MCID: ADN018
MIFTS: 67

Adenoma malady

Summaries for Adenoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A cell type benign neoplasm that is composed of epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards: Adenoma, also known as acinar cell adenoma, is related to pleomorphic adenoma and thyroid adenoma. An important gene associated with Adenoma is PLAGL1 (pleiomorphic adenoma gene-like 1), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and SLC-mediated transmembrane transport. The drugs octreotide and octreotide acetate and the compounds zinc and forskolin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are homeostasis/metabolism and growth/size.

Wikipedia:64 An adenoma (adeno-, \"gland\" + -oma, \"tumor\") (/ˌædɨˈnoʊmə/; plural adenomas or adenomata... more...

Aliases & Classifications for Adenoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

adenoma 8 10 45 61
acinar cell adenoma 8 61
acinic cell adenoma 8
adenomas 8


External Ids:

Disease Ontology8 DOID:657
NCIt40 C2855
MeSH35 D000236

Related Diseases for Adenoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 573)
idRelated DiseaseScoreTop Affiliating Genes
1pleomorphic adenoma31.7PLAGL2, PLAGL1, PLAG1
2thyroid adenoma31.5DIO2
3adenocarcinoma31.2PLAG1, SLC26A3, DIO2, KRAS
4thyroid cancer30.3ADCY1, DIO2, PAX8
5adrenal adenoma11.0
6hepatocellular adenoma10.9
7papillary adenoma10.8
8pleomorphic adenoma carcinoma10.8
9pleomorphic carcinoma10.8
10nephrogenic adenoma10.8
11colorectal cancer10.7
12cushing's syndrome10.7
13chromophobe adenoma10.7
14metanephric adenoma10.7
15growth hormone secreting pituitary adenoma10.7
16primary hyperparathyroidism10.7
17prostatic adenoma10.7
18papillary carcinoma10.6
19familial adenomatous polyposis10.6
20microcystic adenoma10.6
21acromegaly10.6
22parathyroid carcinoma10.6
23pancreatic adenoma10.6
24sebaceous adenoma10.6
25apocrine adenoma10.6
26somatostatin analog10.5
27bile duct adenoma10.5
28clear cell adenoma10.5
29pituitary apoplexy10.5
30breast adenoma10.5
31acth-secreting pituitary adenoma10.5
32prolactinoma10.5
33pregnancy adenoma10.5
34adenomas, salivary gland pleomorphic10.5
35n syndrome10.4
36familial isolated pituitary adenoma10.4
37pituitary tumors10.4
38pheochromocytoma10.4
39silent pituitary adenoma10.4
40multiple endocrine neoplasia10.4
41gangliocytoma10.3
42peutz-jeghers syndrome10.3
43myoepithelial carcinoma10.3
44peutz–jeghers syndrome10.3
45adenomas, multiple colorectal10.3
46hypercalcemia10.3
47fetal adenoma10.3
48eccrine papillary adenoma10.3
49adrenocortical carcinoma10.3
50oxyphilic adenoma10.3

Graphical network of the top 20 diseases related to Adenoma:



Diseases related to adenoma

Clinical Features for Adenoma

Drugs & Therapeutics for Adenoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adenoma

Drug clinical trials:

Search ClinicalTrials for Adenoma

Search NIH Clinical Center for Adenoma

Search CenterWatch for Adenoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Adenoma

Anatomical Context for Adenoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Adenoma:

33
Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Brain, Cortex, Spinal cord, Heart, Smooth muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Uterus, Placenta, Prostate, Testis, Cervix, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Olfactory bulb, Hypothalamus, Pons, Tongue, Fetal liver, Fetal lung, Trachea, Bronchial epithelium, Appendix, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pituitary, Uterus corpus, Testis germ, Testis leydig

Animal Models for Adenoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Adenoma

Sources:
51PubMed
See all sources

Articles related to Adenoma:

(show top 50)    (show all 7541)
idTitleAuthorsYear
1
Modified partial superficial parotidectomy versus conventional superficial parotidectomy improves treatment of pleomorphic adenoma of the parotid gland. (24309016)
2013
2
Short-term folate supplementation in physiological doses has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma. (23328702)
2012
3
How normal is the liver in which the inflammatory type hepatocellular adenoma develops? (23024866)
2012
4
Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. (21744105)
2012
5
Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. (22761217)
2012
6
Intestinal pouch complications in patients who underwent restorative proctocolectomy for ulcerative colitis and familial adenomatous polyposis in 1985-2008. (22166319)
2011
7
Thyroid follicular adenoma composed of lipid-rich cells. (21165779)
2011
8
Familial adenomatous polyposis. (21276387)
2011
9
Immunohistochemical expression of pRb in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. (21196892)
2011
10
Differentiation of hepatocellular adenoma and focal nodular hyperplasia using 18F-fluorocholine PET/CT. (20717825)
2011
11
Hyperplasia-adenoma sequence in pituitary tumorigenesis related to aryl hydrocarbon receptor interacting protein gene mutation. (21450940)
2011
12
Relationship between expression of vascular endothelial growth factor and intratumoral hemorrhage in human pituitary adenomas. (22158497)
2011
13
Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons. (20465538)
2010
14
Erratum to: A novel frameshift mutation in exon 12 of the adenomatous polyposis coli gene in an Italian family with familial adenomatous polyposis and desmoid tumour. (20963189)
2010
15
Giant mediastinal parathyroid adenoma: a case report. (19537125)
2009
16
Symptomatic hyperprolactinemia from an ectopic pituitary adenoma located in the clivus. (19289326)
2009
17
Intraabdominal pulmonary sequestration with congenital cystic adenomatoid malformation. (18985335)
2009
18
Salivary glands and malignancy in pleomorphic adenoma. (19349500)
2009
19
Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia. (18300795)
2008
20
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. (18708408)
2008
21
Giant posterior mediastinal parathyroid adenoma. (18399771)
2008
22
Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. (17684125)
2007
23
Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma]. (18172343)
2007
24
Ectopic parathyroid adenoma--the hidden culprit. (17907504)
2007
25
Urgent colectomy and caesarean section of a pregnant familial adenomatous polyposis: a case report. (16479367)
2007
26
Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas. (16299383)
2006
27
Intrasellar plasmacytoma presenting as a non-functional invasive pituitary macro-adenoma: case report & literature review. (16703411)
2006
28
GSTP1 and GSTA1 polymorphisms interact with cruciferous vegetable intake in colorectal adenoma risk. (16365014)
2005
29
Long-term outcome after ampullectomy for ampullary lesions associated with familial adenomatous polyposis. (16228827)
2005
30
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung. (15950315)
2005
31
Gastric extremely well differentiated adenocarcinoma of gastric phenotype: as a gastric counterpart of adenoma malignum of the uterine cervix. (15907218)
2005
32
46, XY agonadism associated with adrenal adenoma/myelolipoma: report of a case analyzing Y-chromosome-specific sequences. (14710593)
2003
33
Galanin in human pituitary adenomas: frequency and clinical significance. (11940053)
2002
34
In vivo secretory potential and the effect of combination therapy with octreotide and cabergoline in patients with clinically non-functioning pituitary adenomas. (11167922)
2001
35
Lack of communication about familial colorectal cancer risk associated with colorectal adenomas (United States). (10880036)
2000
36
Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer. (10741284)
2000
37
Hepatic adenoma following short period of oral contraceptive use. (10477198)
1999
38
No evidence for overexpression of the p53 protein and mutations in exons 4-9 of the p53 gene in a large family with adenomatous polyposis. (9732936)
1998
39
Pituitary adenoma revealed by paracentral junctional scotoma of traquair. (9097317)
1997
40
Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications. (8954032)
1996
41
Ectopic parathyroid adenoma with severe hungry bone syndrome: a case report. (8828266)
1996
42
Follicular adenoma of the thyroid gland in children. (8555125)
1995
43
Histopathological changes in human prostatic adenoma following neodymium:YAG laser ablation therapy. (7523711)
1994
44
Patterns and composition of basement membranes in colon adenomas and adenocarcinomas. (8133402)
1993
45
Fetal adenoma of the pigmented ciliary epithelium associated with persistent hyperplastic primary vitreous. (3785893)
1986
46
Nephrogenic adenoma of the ureter. (6822246)
1983
47
Letter: Pituitary adenoma in McCune-Albright syndrome: follow-up information. (932890)
1976
48
Case of hyperthyroidism due to a chromophobe adenoma. (1269160)
1976
49
Histochemical studies on thyroid adenoma built of C cells. (4354634)
1972
50
Primary aldosteronism due to adrenocortical adenoma (Conn's syndrome). (5955092)
1966

Genetic Variations for Adenoma

Expression for genes affiliated with Adenoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adenoma

Search GEO for disease gene expression data for Adenoma.

Pathways for genes affiliated with Adenoma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Adenoma according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.4LHCGR, AVPR1B, ADCY7, ADCY6, ADCY1
2
Hide members
11.4SLC26A3, ADCY7, ADCY6, ADCY1, ADCY4
311.4SLC26A3, ADCY7, ADCY6, ADCY1, ADCY4
4
Hide members
11.4LIFR, ADCY7, ADCY6, ADCY1, ADCY4
5
Hide members
11.4ADCY4, ADCY1, ADCY6, ADCY7, LIFR
6
Hide members
11.4ADCY4, ADCY1, ADCY6, ADCY7, LIFR
7
Hide members
11.4LIFR, ADCY7, ADCY6, ADCY1, ADCY4
811.4LHCGR, AVPR1B, ADCY7, ADCY1, ADCY4
911.4AVPR1B, ADCY7, ADCY6, ADCY1, ADCY4
10
Hide members
11.4ADCY4, ADCY1, ADCY6, ADCY7, LHCGR
1111.4ADCY4, ADCY1, ADCY6, ADCY7, LHCGR
1211.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
13
Development Endothelin-1/EDNRA signaling
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
14
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
15
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
16
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
17
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
1811.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
19
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
20
Signal transduction cAMP signaling
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
21
Hide members
11.4KRAS, ADCY7, ADCY6, ADCY1, ADCY4
22
Hide members
11.2PAX8, ADCY7, ADCY6, ADCY1
23
Hide members
11.2KRAS, ADCY7, ADCY6, ADCY1
24
Hide members
11.2ADCY4, ADCY1, ADCY6, ADCY7
25
Hide members
11.2ADCY7, ADCY6, ADCY1, ADCY4
26
Hide members
11.2ADCY7, ADCY6, ADCY1, ADCY4
2711.2ADCY4, ADCY1, ADCY6, ADCY7
2811.2ADCY7, ADCY6, ADCY1, ADCY4
29
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
11.2ADCY4, ADCY1, ADCY6, ADCY7
3011.2ADCY4, ADCY1, ADCY6, ADCY7
31
Hide members
11.2ADCY7, ADCY6, ADCY1, ADCY4
3211.2ADCY7, ADCY6, ADCY1, ADCY4
3311.2ADCY7, ADCY6, ADCY1, ADCY4
34
Hide members
11.2ADCY7, ADCY6, ADCY1, ADCY4
35
Hide members
11.2ADCY4, ADCY1, ADCY6, ADCY7
3611.2ADCY4, ADCY1, ADCY6, ADCY7
3711.2ADCY4, ADCY1, ADCY6, ADCY7
3811.2ADCY7, ADCY6, ADCY1, ADCY4
3911.2ADCY4, ADCY1, ADCY6, ADCY7
40
G-protein signaling G-Protein alpha-i signaling cascades
Hide members
11.2ADCY7, ADCY6, ADCY1, ADCY4
41
Hide members
11.2ADCY4, ADCY1, ADCY6, ADCY7
42
Hide members
11.2ADCY4, ADCY1, ADCY6, ADCY7
43
Hide members
11.0ADCY1, ADCY6, ADCY7
44
Hide members
11.0ADCY1, ADCY6, ADCY7
45
Hide members
11.0ADCY1, ADCY6, ADCY7
46
Hide members
10.8ADCY6, ADCY4
47
Hide members
10.8ADCY1, ADCY4
48
Hide members
10.8ADCY1, ADCY4

Compounds for genes affiliated with Adenoma

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Adenoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1zinc45 2412.7HNF1A, LIFR, PLAG1, PLAGL1, PLAGL2, ZNF331
2forskolin45 50 1113.6ADCY1, ADCY7, PAX8, DIO2, LHCGR
3nkh 4776011.5ADCY4, ADCY1, ADCY6, ADCY7
4mdl 12330a hydrochloride6011.5ADCY7, ADCY6, ADCY1, ADCY4
5pacap 1-276011.5ADCY7, ADCY6, ADCY1, ADCY4
6kh 76011.5ADCY7, ADCY4, ADCY1, ADCY6
7cyclic amp45 2412.5ADCY4, ADCY1, ADCY6, ADCY7, LHCGR
8sq 2253660 4512.5ADCY4, ADCY1, ADCY6, ADCY7
9Pyruvic acid11 2412.4ADCY7, ADCY6, ADCY1, ADCY4
10oligonucleotide4511.4PAX8, KRAS, PLAG1, LIFR, HNF1A
11acth4511.4LHCGR, LIFR, AVPR1B, ADCY1
12nad29 2412.3ADCY7, ADCY6, ADCY1, ADCY4
13phosphoric acid45 2412.2ADCY7, ADCY6, ADCY1, ADCY4
14pyrophosphate45 2412.1ADCY7, ADCY6, ADCY1, ADCY4
15nadh45 11 2412.9ADCY7, ADCY6, ADCY1, ADCY4

GO Terms for genes affiliated with Adenoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Adenoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1activation of phospholipase C activityGO:00720211.7ADCY4, ADCY1, ADCY6, ADCY7, AVPR1B
2fibroblast growth factor receptor signaling pathwayGO:00854311.6ADCY4, ADCY1, ADCY6, ADCY7, KRAS
3epidermal growth factor receptor signaling pathwayGO:00717311.6KRAS, ADCY7, ADCY6, ADCY1, ADCY4
4neurotrophin TRK receptor signaling pathwayGO:04801111.5KRAS, ADCY7, ADCY6, ADCY1, ADCY4
5activation of protein kinase A activityGO:03419911.5ADCY7, ADCY6, ADCY1, ADCY4
6cellular response to glucagon stimulusGO:07137711.5ADCY7, ADCY6, ADCY1, ADCY4
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718911.5ADCY4, ADCY1, ADCY6, ADCY7
8water transportGO:00683311.5ADCY7, ADCY6, ADCY1, ADCY4
9adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719311.5ADCY4, ADCY1, ADCY6, ADCY7
10transmembrane transportGO:05508511.4SLC26A3, ADCY7, ADCY6, ADCY1, ADCY4
11energy reserve metabolic processGO:00611211.4ADCY4, ADCY1, ADCY6, ADCY7
12intracellular signal transductionGO:03555611.3ADCY4, ADCY1, ADCY6, ADCY7
13cAMP biosynthetic processGO:00617111.3ADCY6, ADCY1, ADCY4
14synaptic transmissionGO:00726811.2ADCY4, ADCY1, ADCY6, ADCY7
15innate immune responseGO:04508711.1KRAS, ADCY7, ADCY6, ADCY1, ADCY4
16cellular response to gonadotropin stimulusGO:07137110.7PAX8, LHCGR

Molecular functions related to Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:04687211.8PLAGL1, PLAGL2, ADCY7, ADCY6, ADCY1, ADCY4
2adenylate cyclase activityGO:00401610.7ADCY4, ADCY6, ADCY7

Products for genes affiliated with Adenoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Adenoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet