MCID: ADN018
MIFTS: 64

Adenoma malady

Cancer diseases category

Summaries for Adenoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A cell type benign neoplasm that is composed of epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards: Adenoma, also known as acinar cell adenoma, is related to pleomorphic adenoma and lung adenoma. An important gene associated with Adenoma is PLAGL1 (pleiomorphic adenoma gene-like 1), and among its related pathways are G-AlphaQ Signaling and Calcium signaling pathway. The drugs octreotide and octreotide acetate and the compounds acth and isoproterenol have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and colon, and related mouse phenotypes are behavior/neurological and growth/size/body.

Wikipedia:66 An adenoma (adeno-, \"gland\" + -oma, \"tumor\") (/? more...

Aliases & Classifications for Adenoma

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenoma 9 11 46 63
acinar cell adenoma 9 63
acinic cell adenoma 9
adenomas 9


External Ids:

Disease Ontology9 DOID:657
MeSH36 D000236
NCIt41 C2855

Related Diseases for Adenoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Adenoma:



Diseases related to adenoma

Symptoms for Adenoma

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Drugs & Therapeutics for Adenoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Adenoma

Drug clinical trials:

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Search NIH Clinical Center for Adenoma

Search CenterWatch for Adenoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Adenoma

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Anatomical Context for Adenoma

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34MalaCards
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MalaCards organs/tissues related to Adenoma:

34
Pituitary, Thyroid, Colon, Salivary gland, Prostate, Lung, Pancreas, Kidney, Liver, Bone, Breast, Testes, Endothelial, Adrenal gland, Cervix, Ovary, Trachea, Cortex, Adrenal cortex, Appendix, Tongue, Skin, Lymph node, Small intestine, Smooth muscle, B cells, Bone marrow, Uterus, Placenta, Testis, Monocytes, Thymus, Brain, Pons, Hypothalamus, Eye, T cells, Myeloid

Animal Models for Adenoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.4ADCY5, ADCY8, ADCY7, ADCY1, ADCY6, KRAS
2MP:00053788.9SLC26A3, LHCGR, KRAS, PLAGL2, PLAG1, PLAGL1
3MP:00053768.9ADCY6, SLC26A3, CASC1, PLAGL2, ADCY1, ADCY8

Publications for Adenoma

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53PubMed
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Articles related to Adenoma:

(show top 50)    (show all 6083)
idTitleAuthorsYear
1
Unusual case of Cowden-like syndrome, neck paraganglioma, and pituitary adenoma. (23804288)
2014
2
Melanoma of the sellar region mimicking pituitary adenoma. (22624497)
2013
3
Neurocognitive function in acromegaly after surgical resection of GH-secreting adenoma versus naA^ve acromegaly. (23593161)
2013
4
Metachronous adenoma on ileorectal anastomosis suture line and submucosal deep invasive cancer suspected of rapid growth in rectal remnant following long-term interval after curative surgery for advanced colon cancer. (23617649)
2013
5
Mucinous adenocarcinoma arising from diffuse serrated adenoma of the appendix which mimics appendicular abscess. (23012662)
2012
6
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation. (21744088)
2012
7
TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. (22207630)
2012
8
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
9
Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa. (22950808)
2012
10
Giant parathyroid adenoma. (22610816)
2011
11
Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene. (21362280)
2011
12
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883493)
2011
13
Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation. (19326985)
2009
14
Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma. (19245848)
2009
15
An immunohistochemical study of colon adenomas and carcinomas: E-cadherin, Syndecan-1, Ets-1. (19253033)
2009
16
Pleomorphic adenoma of the main bronchus in an adult treated using a wedge bronchiectomy. (19160012)
2009
17
The use of gamma probe for the intraoperative localization of an ectopic parathyroid adenoma. (19714514)
2009
18
Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma. (19180717)
2008
19
Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. (18351386)
2008
20
Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin. (17592150)
2007
21
Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. (17280594)
2007
22
Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study. (16984249)
2006
23
Genetic mutation in hepatic adenoma: seeing is believing. (17034896)
2006
24
Interesting Case: Maxillary swing approach for resection of a large pleomorphic adenoma arising in the soft palate. (16055235)
2006
25
Magnetic resonance findings of bile duct adenoma with calcification. (16958429)
2006
26
An unusual somatotropin and thyreotropin secreting pituitary adenoma efficiently controlled by Octreotide and Pegvisomant. (16840917)
2006
27
Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management. (16001333)
2005
28
Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. (16086968)
2005
29
Intrathyroidal parathyroid adenoma. (15965320)
2005
30
Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. (16214918)
2005
31
KRAS transitions and villous growth in colorectal adenomas. (16373972)
2005
32
Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas. (15816632)
2005
33
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
34
Chimerism of metanephric adenoma but not of carcinoma in kidney transplants. (15579450)
2004
35
Bilateral asynchronous adrenal adenoma in a girl with an incomplete form of Beckwith-Wiedemann syndrome. (11271390)
2001
36
Visual vignette. Hyperparathyroidism due to a parathyroid adenoma. (11441818)
2000
37
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia. (10348217)
1998
38
Papillary adenoma of the large intestine: a historical perspective. (9731879)
1998
39
Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas. (9666878)
1998
40
Pancreastatin secretion by pituitary adenomas and regulation of chromogranin B mRNA expression. (8669489)
1996
41
Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas. (8162161)
1994
42
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
43
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
44
Decay-accelerating factor (DAF, CD55) in normal colorectal mucosa, adenomas and carcinomas. (1384641)
1992
45
Peutz-Jeghers syndrome in association with adenoma malignum (minimal deviation adenocarcinoma) of the cervix. Case report. (2804013)
1989
46
Solitary hyperfunctioning thyroid adenoma in a child. Elevated T3 and T4 levels with normal TSH level. (1242753)
1975
47
Chromophobe adenoma masquerading as corticosteroid-responsive optic neuritis. (4369864)
1974
48
Testosterone-secreting adrenal adenoma under gonadotropin control. (4728749)
1973
49
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970
50
Fibro-adenoma of the ovary with ascites and hydrothorax (Meigs' syndrome). (14814476)
1951

Variations for Adenoma

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Expression for genes affiliated with Adenoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenoma

Search GEO for disease gene expression data for Adenoma.

Pathways for genes affiliated with Adenoma

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Sources:
51PathCards, 54QIAGEN, 31KEGG, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database, 52PharmGKB, 13EMD Millipore
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Pathways related to Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.3ADCY1
29.1LHCGR, ADCY3, ADCY8, ADCY7, ADCY9, ADCY4
38.9ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
4
Show member pathways
8.9ADCY5, ADCY8, ADCY7, ADCY9, ADCY4, ADCY1
5
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
6
Show member pathways
8.9ADCY4, ADCY1, ADCY2, ADCY6, ADCY3, ADCY5
7
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
8
Show member pathways
UTP and CTP dephosphorylation II39
ATP ITP metabolism61
purine deoxyribonucleosides salvage39
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
9
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
10
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
11
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
12
Show member pathways
8.9ADCY5, ADCY8, ADCY7, ADCY9, ADCY4, ADCY1
13
Show member pathways
Calcium Regulation in the Cardiac Cell39
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
14
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
15
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
16
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
17
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
18
Show member pathways
Development Beta adrenergic receptors regulation of ERK61
G protein signaling G Protein alpha s signaling cascades61
G protein signaling G Protein beta gamma signaling cascades61
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
198.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
20
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
21
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
228.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
238.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
248.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
258.9ADCY2, ADCY6, ADCY1, ADCY4, ADCY3, ADCY5
268.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
278.9ADCY6, ADCY2, ADCY3, ADCY5, ADCY8, ADCY7
28
Show member pathways
8.9ADCY4, ADCY1, ADCY2, ADCY6, ADCY9, ADCY7
298.9ADCY7, ADCY9, ADCY4, ADCY1, ADCY2, ADCY6
308.8ADCY9, ADCY4, ADCY1, ADCY2, ADCY6, SLC26A3
31
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
32
Show member pathways
8.8ADCY8, ADCY5, ADCY3, LIFR, ADCY7, ADCY9
33
Show member pathways
8.8ADCY2, ADCY1, ADCY4, ADCY9, ADCY7, ADCY8
34
Show member pathways
8.8LIFR, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
35
Show member pathways
8.8LIFR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
36
Show member pathways
8.8ADCY8, ADCY5, ADCY3, LHCGR, ADCY7, ADCY9
378.8LHCGR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
38
Show member pathways
8.8LHCGR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
398.8LHCGR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
40
Show member pathways
8.8ADCY8, ADCY7, ADCY9, ADCY4, ADCY1, ADCY2
41
Show member pathways
Signal transduction cAMP signaling61
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
42
Show member pathways
8.8KRAS, ADCY6, ADCY3, ADCY5, ADCY8, ADCY7
43
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
44
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
458.8ADCY8, ADCY7, ADCY9, ADCY4, ADCY1, ADCY2
46
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
47
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
48
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
49
Show member pathways
8.8KRAS, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
50
Show member pathways
8.8ADCY2, ADCY6, KRAS, ADCY1, ADCY4, ADCY9

Compounds for genes affiliated with Adenoma

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Adenoma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1acth4610.0LHCGR, LIFR, ADCY1
2isoproterenol46 1210.6ADCY7, ADCY3, ADCY2, LHCGR, ADCY1
3dopamine46 30 25 1212.5ADCY6, ADCY5, ADCY1, ADCY2
4adenylate469.4ADCY5, ADCY3, LHCGR, ADCY1, ADCY9, PLAGL1
5forskolin46 52 1211.3ADCY3, LHCGR, ADCY5, ADCY7, ADCY9, ADCY1
6nkh 477629.2ADCY5, ADCY3, ADCY8, ADCY7, ADCY9, ADCY6
7kh 7629.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
8pacap 1-27629.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
9sq 2253646 6210.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
10Pyruvic acid25 1210.2ADCY3, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
11Cyclic GMP259.2ADCY1, ADCY4, ADCY9, ADCY7, ADCY5, ADCY3
12mdl 12330a hydrochloride629.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY3
13nad30 2510.2ADCY2, ADCY1, ADCY4, ADCY9, ADCY3, ADCY7
14phosphoric acid46 2510.2ADCY6, ADCY5, ADCY3, ADCY8, ADCY7, ADCY9
15pyrophosphate46 2510.2ADCY7, ADCY8, ADCY5, ADCY3, ADCY9, ADCY4
16nadh46 25 1211.1ADCY2, ADCY6, ADCY1, ADCY4, ADCY9, ADCY7
17magnesium46 25 1211.1ADCY1, ADCY4, ADCY9, ADCY7, ADCY8, ADCY3
18Adenosine triphosphate25 1210.0ADCY8, ADCY3, ADCY9, ADCY1, ADCY2, ADCY6
19Guanosine triphosphate259.0ADCY2, ADCY6, KRAS, ADCY5, ADCY1, ADCY4
20cyclic amp46 2510.0LHCGR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
21calcium46 52 25 1211.7ADCY7, ADCY2, ADCY5, ADCY1, ADCY8, ADCY4

GO Terms for genes affiliated with Adenoma

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17Gene Ontology
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Cellular components related to Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160209.6ADCY4, ADCY2, ADCY6, SLC26A3, ADCY8
2plasma membraneGO:0058868.2SLC26A3, LHCGR, ADCY3, ADCY5, ADCY8, ADCY7

Biological processes related to Adenoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.1ADCY4, ADCY2
2long-term memoryGO:0076169.8ADCY1, ADCY8
3cAMP biosynthetic processGO:0061719.8ADCY6, ADCY2, ADCY4
4adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.2ADCY4, ADCY9, ADCY7, ADCY8, ADCY5, ADCY3
5activation of phospholipase C activityGO:0072029.2ADCY3, ADCY5, ADCY8, ADCY6, ADCY2, ADCY1
6activation of protein kinase A activityGO:0341999.2ADCY5, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
7cellular response to glucagon stimulusGO:0713779.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
8water transportGO:0068339.2ADCY5, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
9energy reserve metabolic processGO:0061129.2ADCY5, ADCY3, ADCY8, ADCY7, ADCY9, ADCY2
10adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.1ADCY4, ADCY9, ADCY7, ADCY8, ADCY5, ADCY3
11intracellular signal transductionGO:0355569.1ADCY4, ADCY9, ADCY7, ADCY8, ADCY5, ADCY3
12fibroblast growth factor receptor signaling pathwayGO:0085439.1KRAS, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
13neurotrophin TRK receptor signaling pathwayGO:0480119.1ADCY7, ADCY8, ADCY5, ADCY3, ADCY9, ADCY4
14synaptic transmissionGO:0072689.0ADCY8, ADCY5, ADCY6, ADCY2, ADCY3, ADCY1
15epidermal growth factor receptor signaling pathwayGO:0071739.0ADCY7, ADCY9, ADCY4, ADCY1, ADCY2, ADCY6
16signal transductionGO:0071659.0ADCY7, ADCY4, ADCY1, ADCY8, ADCY5, ADCY3
17transmembrane transportGO:0550859.0ADCY8, ADCY7, ADCY9, ADCY4, ADCY1, ADCY2
18small molecule metabolic processGO:0442818.9ADCY2, ADCY6, ADCY1, ADCY4, ADCY9, ADCY8
19innate immune responseGO:0450878.9ADCY6, KRAS, ADCY3, ADCY5, ADCY8, ADCY7

Molecular functions related to Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase bindingGO:00817910.1ADCY5, ADCY2
2calcium- and calmodulin-responsive adenylate cyclase activityGO:0082949.8ADCY2, ADCY1, ADCY8
3adenylate cyclase activityGO:0040169.2ADCY6, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
4ATP bindingGO:0055248.6ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
5metal ion bindingGO:0468728.4PLAG1, PLAGL1, ADCY6, ADCY2, ADCY1, ADCY4

Products for genes affiliated with Adenoma

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Sources for Adenoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet