MCID: ADN018
MIFTS: 66

Adenoma malady

Cancer diseases category
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Summaries for Adenoma

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Disease Ontology:8 A cell type benign neoplasm that is composed of epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards based summary: Adenoma, also known as acinar cell adenoma, is related to pleomorphic adenoma and lung adenoma. An important gene associated with Adenoma is PLAGL1 (pleiomorphic adenoma gene-like 1), and among its related pathways are G-AlphaQ Signaling and Calcium signaling pathway. The drugs octreotide and octreotide acetate and the compounds acth and isoproterenol have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and colon, and related mouse phenotypes are behavior/neurological and growth/size/body.

Wikipedia:65 An adenoma (from Greek ??????, adeno-, \"gland\" + -???, -oma, \"tumor\") (/? more...

Aliases & Classifications for Adenoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
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Adenoma, Aliases & Descriptions:

Name: Adenoma 8 10 44 62
Acinar Cell Adenoma 8 62
 
Adenomas 8 62
Acinic Cell Adenoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:657
MeSH34 D000236
NCIt39 C2855

Related Diseases for Adenoma

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Graphical network of the top 20 diseases related to Adenoma:



Diseases related to adenoma

Symptoms for Adenoma

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Drugs & Therapeutics for Adenoma

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Drug clinical trials:

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Search NIH Clinical Center for Adenoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Adenoma

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Anatomical Context for Adenoma

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MalaCards organs/tissues related to Adenoma:

32
Pituitary, Thyroid, Colon, Salivary gland, Prostate, Lung, Pancreas, Kidney, Liver, Bone, Breast, Testes, Endothelial, Adrenal gland, Cervix, Ovary, Trachea, Appendix, Cortex, Adrenal cortex, Skin, Tongue, Lymph node, Bone marrow, Small intestine, Smooth muscle, Uterus, Placenta, Testis, B cells, Thymus, Brain, Monocytes, Eye, Myeloid, T cells, Hypothalamus, Pons, Neutrophil

Animal Models for Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.4ADCY5, ADCY8, ADCY7, ADCY1, ADCY6, KRAS
2MP:00053788.9LHCGR, LIFR, ADCY3, ADCY8, PLAGL1, PLAG1
3MP:00053768.9SLC26A3, LHCGR, LIFR, ADCY5, ADCY8, ADCY1

Publications for Adenoma

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Articles related to Adenoma:

(show top 50)    (show all 6313)
idTitleAuthorsYear
1
A rare case of a parathyroid adenoma inside a parathyroid cyst. (25372589)
2014
2
Nephrogenic adenoma of the urethra presenting as hematuria. (25177122)
2014
3
Brown tumor in a patient with ectopic mediastinal parathyroid adenoma: A case report. (25408600)
2014
4
Coexisting pancreatic mucinous cyst adenoma and adrenal lymphangioma. (25224209)
2014
5
Unusual case of Cowden-like syndrome, neck paraganglioma, and pituitary adenoma. (23804288)
2014
6
Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome. (25120617)
2014
7
Analysis of operative efficacy for giant pituitary adenoma. (25163653)
2014
8
Melanoma of the sellar region mimicking pituitary adenoma. (22624497)
2013
9
Neurocognitive function in acromegaly after surgical resection of GH-secreting adenoma versus naA^ve acromegaly. (23593161)
2013
10
Metachronous adenoma on ileorectal anastomosis suture line and submucosal deep invasive cancer suspected of rapid growth in rectal remnant following long-term interval after curative surgery for advanced colon cancer. (23617649)
2013
11
Mucinous adenocarcinoma arising from diffuse serrated adenoma of the appendix which mimics appendicular abscess. (23012662)
2012
12
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation. (21744088)
2012
13
TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. (22207630)
2012
14
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
15
Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa. (22950808)
2012
16
Giant parathyroid adenoma. (22610816)
2011
17
Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene. (21362280)
2011
18
Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation. (19326985)
2009
19
Familial adenomatous polyposis-associated ampullary adenoma: response to chemotherapy for concurrent metastatic adenocarcinoma. (19245848)
2009
20
An immunohistochemical study of colon adenomas and carcinomas: E-cadherin, Syndecan-1, Ets-1. (19253033)
2009
21
Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma. (19180717)
2008
22
Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. (18351386)
2008
23
Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin. (17592150)
2007
24
Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. (17280594)
2007
25
Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study. (16984249)
2006
26
Genetic mutation in hepatic adenoma: seeing is believing. (17034896)
2006
27
Interesting Case: Maxillary swing approach for resection of a large pleomorphic adenoma arising in the soft palate. (16055235)
2006
28
Magnetic resonance findings of bile duct adenoma with calcification. (16958429)
2006
29
An unusual somatotropin and thyreotropin secreting pituitary adenoma efficiently controlled by Octreotide and Pegvisomant. (16840917)
2006
30
Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management. (16001333)
2005
31
Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. (16086968)
2005
32
Intrathyroidal parathyroid adenoma. (15965320)
2005
33
Genetic polymorphisms of flavin monooxygenase 3 in sulindac-induced regression of colorectal adenomas in familial adenomatous polyposis. (16214918)
2005
34
KRAS transitions and villous growth in colorectal adenomas. (16373972)
2005
35
Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas. (15816632)
2005
36
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
37
Chimerism of metanephric adenoma but not of carcinoma in kidney transplants. (15579450)
2004
38
Visual vignette. Hyperparathyroidism due to a parathyroid adenoma. (11441818)
2000
39
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia. (10348217)
1998
40
Papillary adenoma of the large intestine: a historical perspective. (9731879)
1998
41
Pancreastatin secretion by pituitary adenomas and regulation of chromogranin B mRNA expression. (8669489)
1996
42
Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas. (8162161)
1994
43
Unusual scintigraphic findings in a thyroid adenoma. (8441041)
1993
44
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
45
Decay-accelerating factor (DAF, CD55) in normal colorectal mucosa, adenomas and carcinomas. (1384641)
1992
46
Peutz-Jeghers syndrome in association with adenoma malignum (minimal deviation adenocarcinoma) of the cervix. Case report. (2804013)
1989
47
Solitary hyperfunctioning thyroid adenoma in a child. Elevated T3 and T4 levels with normal TSH level. (1242753)
1975
48
Testosterone-secreting adrenal adenoma under gonadotropin control. (4728749)
1973
49
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970
50
Fibro-adenoma of the ovary with ascites and hydrothorax (Meigs' syndrome). (14814476)
1951

Variations for Adenoma

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Expression for genes affiliated with Adenoma

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Expression patterns in normal tissues for genes affiliated with Adenoma

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Pathways for genes affiliated with Adenoma

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Pathways related to Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.3ADCY1
29.1ADCY3, ADCY8, ADCY7, ADCY9, ADCY4, ADCY1
3
Show member pathways
8.9ADCY9, ADCY4, ADCY1, ADCY2, ADCY6, ADCY7
48.9ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
5
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.9ADCY3, ADCY6, ADCY5, ADCY8, ADCY7, ADCY9
68.9ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
7
Show member pathways
8.9ADCY2, ADCY1, ADCY4, ADCY6, ADCY7, ADCY8
8
Show member pathways
8.9ADCY5, ADCY8, ADCY7, ADCY9, ADCY4, ADCY1
98.9ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
108.9ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
11
Show member pathways
8.9ADCY1, ADCY2, ADCY6, ADCY4, ADCY9, ADCY7
12
Show member pathways
8.9ADCY4, ADCY1, ADCY2, ADCY7, ADCY3, ADCY8
138.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
14
Show member pathways
8.9ADCY6, ADCY4, ADCY9, ADCY7, ADCY1, ADCY8
15
Show member pathways
8.9ADCY4, ADCY6, ADCY3, ADCY2, ADCY8, ADCY1
16
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
178.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
18
Show member pathways
UTP and CTP dephosphorylation II37
ATP ITP metabolism60
purine deoxyribonucleosides salvage37
8.9ADCY1, ADCY3, ADCY2, ADCY4, ADCY9, ADCY7
19
Show member pathways
8.9ADCY2, ADCY1, ADCY3, ADCY5, ADCY8, ADCY7
208.9ADCY1, ADCY4, ADCY9, ADCY7, ADCY8, ADCY5
218.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
22
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
23
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
24
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
25
Show member pathways
8.9ADCY7, ADCY9, ADCY4, ADCY1, ADCY2, ADCY8
26
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
27
Show member pathways
8.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
28
Show member pathways
8.9ADCY5, ADCY1, ADCY2, ADCY4, ADCY9, ADCY7
298.9ADCY9, ADCY5, ADCY8, ADCY7, ADCY4, ADCY1
308.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
31
Show member pathways
8.8ADCY9, ADCY5, ADCY8, ADCY7, ADCY4, ADCY1
32
Show member pathways
8.8ADCY1, ADCY3, ADCY2, ADCY4, ADCY9, ADCY7
33
Show member pathways
8.8ADCY3, LIFR, ADCY2, ADCY5, ADCY8, ADCY6
34
Show member pathways
8.8ADCY3, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
35
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY7, LIFR
368.8LHCGR, ADCY3, ADCY8, ADCY7, ADCY6, ADCY2
37
Show member pathways
8.8LHCGR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
38
Show member pathways
8.8LHCGR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY1
398.8ADCY5, ADCY3, ADCY6, ADCY2, ADCY1, ADCY4
40
Show member pathways
8.8ADCY2, ADCY6, ADCY1, ADCY4, ADCY9, ADCY7
41
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
42
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
438.8ADCY1, ADCY4, ADCY9, ADCY7, ADCY8, ADCY5
44
Show member pathways
8.8KRAS, ADCY6, ADCY2, ADCY7, ADCY1, ADCY3
45
Show member pathways
8.8ADCY3, ADCY5, ADCY8, ADCY7, ADCY4, ADCY1
46
Show member pathways
8.8KRAS, ADCY6, ADCY2, ADCY1, ADCY7, ADCY8
47
Show member pathways
8.8ADCY3, ADCY5, KRAS, ADCY6, ADCY2, ADCY1
48
Show member pathways
Signal transduction cAMP signaling60
8.8ADCY7, ADCY9, ADCY4, ADCY1, ADCY2, ADCY6
49
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.8KRAS, ADCY7, ADCY8, ADCY5, ADCY3, ADCY9
50
Show member pathways
8.8ADCY9, ADCY7, ADCY8, ADCY5, ADCY3, ADCY6

Compounds for genes affiliated with Adenoma

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Compounds related to Adenoma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1acth4410.0ADCY1, LIFR, LHCGR
2isoproterenol44 1110.6LHCGR, ADCY3, ADCY7, ADCY1, ADCY2
3dopamine44 28 24 1112.5ADCY5, ADCY1, ADCY2, ADCY6
4adenylate449.4LHCGR, ADCY3, ADCY5, ADCY9, ADCY1, ADCY2
5forskolin44 50 1111.3LHCGR, ADCY3, ADCY5, ADCY7, ADCY9, ADCY1
6Pyruvic acid24 1110.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
7Cyclic GMP249.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY3, ADCY5
8mdl 12330a hydrochloride619.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
9pacap 1-27619.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
10sq 2253644 6110.2ADCY6, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
11nkh 477619.2ADCY9, ADCY4, ADCY1, ADCY2, ADCY6, ADCY7
12kh 7619.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY6, ADCY2
13nad28 2410.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
14phosphoric acid44 2410.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
15pyrophosphate44 2410.2ADCY2, ADCY1, ADCY4, ADCY9, ADCY7, ADCY8
16nadh44 24 1111.1ADCY3, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
17magnesium44 24 1111.1ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
18Adenosine triphosphate24 1110.0ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
19Guanosine triphosphate249.0ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
20cyclic amp44 2410.0ADCY8, ADCY5, ADCY3, LHCGR, ADCY7, ADCY9
21calcium44 50 24 1111.7LHCGR, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9

GO Terms for genes affiliated with Adenoma

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Cellular components related to Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160209.6ADCY4, ADCY2, ADCY6, SLC26A3, ADCY8
2plasma membraneGO:0058868.2SLC26A3, LHCGR, ADCY3, ADCY5, ADCY8, ADCY7

Biological processes related to Adenoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.1ADCY2, ADCY4
2long-term memoryGO:0076169.8ADCY1, ADCY8
3cAMP biosynthetic processGO:0061719.8ADCY4, ADCY2, ADCY6
4water transportGO:0068339.2ADCY3, ADCY5, ADCY6, ADCY2, ADCY1, ADCY4
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.2ADCY4, ADCY9, ADCY7, ADCY8, ADCY5, ADCY3
6activation of phospholipase C activityGO:0072029.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
7adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
8activation of protein kinase A activityGO:0341999.2ADCY3, ADCY5, ADCY8, ADCY7, ADCY6, ADCY2
9cellular response to glucagon stimulusGO:0713779.2ADCY6, ADCY2, ADCY1, ADCY4, ADCY9, ADCY7
10energy reserve metabolic processGO:0061129.1ADCY8, ADCY5, ADCY3, ADCY7, ADCY9, ADCY6
11intracellular signal transductionGO:0355569.1ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
12synaptic transmissionGO:0072689.0ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
13epidermal growth factor receptor signaling pathwayGO:0071739.0KRAS, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
14fibroblast growth factor receptor signaling pathwayGO:0085439.0ADCY1, ADCY4, ADCY9, ADCY7, ADCY8, ADCY5
15neurotrophin TRK receptor signaling pathwayGO:0480119.0KRAS, ADCY6, ADCY2, ADCY1, ADCY4, ADCY9
16signal transductionGO:0071659.0ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
17transmembrane transportGO:0550859.0ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
18small molecule metabolic processGO:0442818.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
19innate immune responseGO:0450878.9ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4

Molecular functions related to Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase bindingGO:00817910.1ADCY2, ADCY5
2calcium- and calmodulin-responsive adenylate cyclase activityGO:0082949.8ADCY8, ADCY1, ADCY2
3adenylate cyclase activityGO:0040169.2ADCY6, ADCY3, ADCY5, ADCY8, ADCY7, ADCY9
4ATP bindingGO:0055248.6ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4
5metal ion bindingGO:0468728.4ADCY3, ADCY5, ADCY8, ADCY7, ADCY9, ADCY4

Products for genes affiliated with Adenoma

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Sources for Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet