Adenomatous Polyposis Coli malady

Genetics Home Reference: Familial adenomatous polyposis (FAP) is an inherited disorder characterized by cancer of the large intestine (colon) and rectum. People with the classic type of familial adenomatous polyposis may begin to develop multiple noncancerous (benign) growths (polyps) in the colon as early as their teenage years. Unless the colon is removed, these polyps will become malignant (cancerous). The average age at which an individual develops colon cancer in classic familial adenomatous polyposis is 39 years. Some people have a variant of the disorder, called attenuated familial adenomatous polyposis, in which polyp growth is delayed. The average age of colorectal cancer onset for attenuated familial adenomatous polyposis is 55 years.¹⁷

MalaCards: Adenomatous Polyposis Coli is related to colorectal cancer and turcot syndrome. An important gene associated with Adenomatous Polyposis Coli is APC2 (adenomatosis polyposis coli 2), and among its related pathways are Basal cell carcinoma and Reelin Pathway (Cajal-Retzius cells). The drug celecoxib and the compounds h2o2 and egcg have been mentioned in the context of this disorder. Affiliated tissues include thymus, brain and cortex, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in...⁴⁴ more...

OMIM: 175100

adenomatous polyposis coli 7 33 43

Diseases related to adenomatous polyposis coli by text searches and GeneDecks gene sharing:

(show top 50)    (show all 544)

id	Related Disease	Score	Top Affiliating Genes
1	colorectal cancer	35.5	MSH2, MLH1, APC, CCND1, TP53, PLA2G2A
2	turcot syndrome	34.0	MSH2, MLH1, APC, PMS2
3	attenuated familial adenomatous polyposis	33.3	MUTYH, MSH2, APC, PTGS2, CTNNB1
4	familial adenomatous polyposis	32.0	KLF4, REEP5, PCNA, BTRC, MYC, BMP6
5	mutyh-associated polyposis	31.9	MUTYH, APC, TP53
6	breast cancer	31.8	KLF4, BCL2, MSH2, MLH1, AR, CCND1
7	desmoid tumor	31.4	PCNA, CDH2, AR, APC, CCND1, ESR1
8	parathyroid carcinoma	31.3	CDC73, GSK3B, CCND1, TP53
9	basal cell carcinoma	31.2	BCL2, JUP, CCNB1, TP53, PTCH1, CTNNB1
10	familial colorectal cancer	30.7	BCL2, MUTYH, MSH2, CDH1, MLH1, MIR135A1
11	inflammatory breast cancer	30.2	MYC, BIRC5, MUC1, CDH1, FGF2, APC
12	gastroduodenitis	30.0	BMP6, MUC1, FGF2, TP53, PTGS2, PTGS1
13	fibromatosis	29.9	PCNA, MYC, CDH2, AR, APC, PTGS2
14	autism spectrum disorder	29.9	PIK3CG, BCL2, MUC1, UBE3A, AR, APC
15	oral submucous fibrosis	29.3	PCNA, BIRC5, FGF2, TP53, PTGS2, NOS2
16	polyposis	29.3	PIH1D1, PIK3CG, KLF4, REEP5, KIFAP3, KIF2C
17	choriocarcinoma	27.7	PIK3CG, PCNA, MYC, JUP, CDKN1A, APC
18	germ cell tumor	27.4	PCNA, BUB1B, BIRC5, BCL2, MSH2, CDKN1A
19	medulloblastoma	26.9	PIK3CG, KLF4, PCNA, BTRC, MYC, BIRC5
20	duodenitis	26.5	PIK3CG, PCNA, BCL2, MUC1, AXIN2, MSH2
21	squamous cell carcinoma	25.2	KLF4, PCNA, MYC, BMP6, USF2, BIRC5
22	schizophrenia	25.2	PIK3CG, KIFAP3, PCNA, PCNT, BMP6, CLU
23	adenoma	24.8	KLF4, PCNA, MYC, BMP6, RAN, BIRC5
24	retinoblastoma	24.7	PIK3CG, PCNA, LMNA, MYC, BMP6, RAN
25	colon cancer	24.5	PIK3CG, KLF4, PCNA, BUB1, BUB1B, BTRC
26	colon carcinoma	24.4	PIK3CG, KLF4, LMNA, MYC, BMP6, BIRC5
27	hepatitis b	24.3	PIK3CG, PCNA, MYC, BMP6, BIRC5, BCL2
28	oral squamous cell carcinoma	24.1	PCNA, BUB1B, LMNA, MYC, BMP6, BIRC5
29	cerebritis	23.5	PIK3CG, KLF4, PCNA, PCNT, LMNA, MYC
30	esophageal squamous cell carcinoma	23.3	PCNA, LMNA, MYC, BMP6, BIRC5, CLU
31	fibrosis	22.9	PIK3CG, PCNA, LMNA, MYC, BMP6, BIRC5
32	thyroid carcinoma	22.9	PIK3CG, PCNA, MYC, BMP6, BIRC5, BCL2
33	carcinoma	22.7	PIK3CG, KLF4, REEP5, KIF2C, PCNA, PCNT
34	neuronitis	21.9	PIK3CG, KLF4, KIFAP3, PCNA, PCNT, BTRC
35	thyroiditis	21.9	PIK3CG, KLF4, PCNA, BUB1, BUB1B, MYC
36	hepatocellular carcinoma	21.2	PIK3CG, PCNA, BUB1, BUB1B, BUB3, BTRC
37	gastric cancer	21.2	PIK3CG, KLF4, KIF2C, PCNA, BUB1, BUB1B
38	ovarian carcinoma	21.2	PIK3CG, PCNA, BUB1B, MYC, BMP6, RAN
39	hepatitis	21.0	PIK3CG, PCNA, LMNA, MYC, BMP6, USF2
40	melanoma	20.2	PIK3CG, KIF2C, PCNA, BUB1, BUB1B, BTRC
41	esophagitis	20.1	PIK3CG, KLF4, PCNA, BUB1B, LMNA, MYC
42	hypoxia	19.9	PIK3CG, PCNA, BTRC, LMNA, MYC, BMP6
43	pancreatitis	19.1	PIK3CG, KLF4, PCNA, PCNT, BUB1, BUB1B
44	adenocarcinoma	19.1	PIK3CG, KLF4, PCNA, BUB1, BUB1B, BTRC
45	gardner syndrome	14.1	APC, MAPRE1, CTNNB1
46	gastrointestinal stromal tumor	13.9	CDX2, APC, PTGS2, CTNNB1
47	small intestine adenocarcinoma	13.9	MUC1, CDX2, APC, CTNNB1
48	breast metaplastic carcinoma	13.9	AXIN1, APC, TP53, CTNNB1
49	nonpapillary renal cell carcinoma	13.8	CLU, APC, MCC, CTNNA1
50	cerebellar liponeurocytoma	13.8	APC, TP53, PTCH1, CTNNB1

Clinical features from OMIM: 175100

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 celecoxib

MalaCards organs/tissues related to adenomatous polyposis coli:

²²

MGI Mouse Phenotypes related to adenomatous polyposis coli:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.5	DLG1, CDX2, CDC42, CDC73, AXIN2, SCRIB
2	respiratory system phenotype	MP:0005388	10.4	POLB, SP3, DLG1, FEN1, CDC73, SCRIB
3	craniofacial phenotype	MP:0005382	10.3	CSNK2A1, KLF4, AXIN2, ATF4, GSK3B, TCF7L2
4	liver/biliary system phenotype	MP:0005370	10.0	TP53, SP3, PPP2CA, HIF1A, SIAH1, HNF1A
5	limbs/digits/tail phenotype	MP:0005371	9.8	PTCH1, DLG1, CTNNA1, CTNNB1, RXRA, TFAP2A
6	pigmentation phenotype	MP:0001186	9.3	TFAP2A, RXRA, CTNNB1, PTCH1, TP53, CASP3
7	hearing/vestibular/ear phenotype	MP:0005377	9.0	CTNNB1, RXRA, DVL1, TFAP2A, PRKDC, CSNK2A1
8	renal/urinary system phenotype	MP:0005367	8.9	CTNNB1, DLG1, PTGS1, PTGER1, PTCH1, CTNNBIP1
9	behavior/neurological phenotype	MP:0005386	8.7	RXRA, NOS2, CTNNB1, DDIT3, DLG2, DLG1
10	no phenotypic analysis	MP:0003012	8.4	TP53, PTGS2, DLG1, CTNNB1, DHRS9, CSNK1E
11	normal phenotype	MP:0002873	8.3	MCC, HNF4A, PTCH1, PPP1R15A, PPP2CA, RXRA
12	reproductive system phenotype	MP:0005389	8.3	ATF4, KLF4, BUB1, AXIN2, AXIN1, UBE3A
13	nervous system phenotype	MP:0003631	8.3	RHOA, CCND1, APC2, FEN1, FGF2, GSK3B
14	adipose tissue phenotype	MP:0005375	8.1	FAM123B, HNF1A, ESR1, TP53, PTGS2, NOS2
15	immune system phenotype	MP:0005387	8.1	COPS8, MBL2, FAM123B, FEN1, CDC73, JUP
16	skeleton phenotype	MP:0005390	8.0	WNT1, PGR, TFAP2A, DVL1, HIF1A, RXRA
17	integument phenotype	MP:0010771	7.5	BCL2, USF2, MYC, BUB3, BUB1B, KIFAP3
18	hematopoietic system phenotype	MP:0005397	7.5	HGF, WNT1, PMS2, POLB, PRKDC, TCF4
19	embryogenesis phenotype	MP:0005380	7.5	GADD45A, WNT1, PGR, POLB, CTNNA1, SP3
20	vision/eye phenotype	MP:0005391	7.2	CTNNBIP1, CTNNB1, SP3, DLG1, PTPN13, PTGS2
21	muscle phenotype	MP:0005369	6.7	BUB1B, KIFAP3, PIK3CG, HDAC9, WNT1, PGR
22	tumorigenesis	MP:0002006	6.6	SCRIB, BCL2, KHDRBS1, MYC, BTRC, BUB3
23	mortality/aging	MP:0010768	6.4	COPS5, TP53BP2, TP53, HNF4A, CASP7, CCND1
24	digestive/alimentary phenotype	MP:0005381	6.3	APC, AXIN1, MUC1, SCRIB, BCL2, MYC
25	cardiovascular system phenotype	MP:0005385	6.2	GADD45A, HGF, HDAC9, ADCY10, CTBP1, SP3
26	growth/size phenotype	MP:0005378	4.7	BUB1, PCNT, PIK3CG, COPS3, TP53, HNF4A
27	homeostasis/metabolism phenotype	MP:0005376	4.4	COPS5, RXRA, NOS2, CTNNB1, SP3, DDIT3
28	cellular phenotype	MP:0005384	3.1	TCF4, TFAP2A, TGFB1, HIF1A, H2AFX, ACP1

Articles related to adenomatous polyposis coli:

(show top 50)    (show all 206)

id	Title	Authors	Year	Affiliating Genes
1	Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam 68. (22000517)	Morishita E.C.... Yokoyama S.	2011	APC, KHDRBS1
2	Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma. (18486530)	Siriwardena B.S.... Takata T.	2009	APC, CTNNB1
3	Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication. (18844223)	Kastritis E.... Bamias A.	2009	APC, WNT1, CTNNBIP1
4	Novel human pathological mutations. Gene symbol: APC. Disease: Adenomatous polyposis coli. (19694001)	Mavrogiannis L.A.... Charlton R.S.	2009	APC
5	The adenomatous polyposis coli tumor suppressor and W nt signaling in the regulation of apoptosis. (19928354)	Benchabane H.... Ahmed Y.	2009	APC
6	Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. (19149881)	Ivaniutsin U.... Pratt T.	2009	AXIN2, PCNT
7	Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells. (18774639)	Wang H.... Chakrabarty S.	2008	TGFB1, APC, BMP6
8	Germline mutation of adenomatous polyposis coli gene in Chinese patients with familial adenomatous polyposis (18393246)	Wang T.T.... Zhang X.M.	2008	APC
9	Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. (18632633)	Nagel R.... Agami R.	2008	APC, MIR135A1
10	Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma. (18937283)	Orimo T.... Kondo T.	2008	CDC42, MYC, RHOA
11	A novel function of adenomatous polyposis coli (APC) in regulating DNA repair. (18662849)	Jaiswal A.S.... Narayan S.	2008	APC
12	Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. (18716166)	Yang K.... Lipkin M.	2008	APC, CCND1
13	Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. (18716223)	Purro S.A.... Salinas P.C.	2008	DVL1
14	Methylation of the adenomatous polyposis coli (APC) gene in human placenta and hypermethylation in choriocarcinoma cells. (18485586)	Wong N.C.... Saffery R.	2008	APC
15	Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. (18403596)	Gaspar C.... Fodde R.	2008	APC, CTNNB1, MUTYH
16	The in vivo rate of somatic adenomatous polyposis coli mutation. (18321998)	Hornsby C.... Tomlinson I.	2008	APC
17	Impact of adenomatous polyposis coli (APC) tumor supressor gene in human colon cancer cell lines on cell cycle arrest by apigenin. (17620292)	Chung C.S.... Birt D.F.	2007	APC
18	How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population. (17854661)	Dundar M.... Ozkul Y.	2007	APC
19	Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. (17192415)	Kroboth K.... Nathke I.S.	2007	APC
20	Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. (17028196)	Nadauld L.D.... Jones D.A.	2006	APC, CTBP1
21	Mutations of APC and MYH in unrelated Italian patients with adenomatous polyposis coli. (16134147)	Aceto G.... Cama A.	2005	APC, MUTYH
22	Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK. (15649893)	Hildesheim J.... Fornace A.J.	2005	CTNNB1
23	Systematic peptide array-based delineation of the differential beta-catenin interaction with Tcf4, E-cadherin, and adenomatous polyposis coli. (15591320)	Gail R.... Wittinghofer A.	2005	CDH1, APC, CTNNB1
24	Novel germline mutations in the adenomatous polyposis coli gene in Polish families with familial adenomatous polyposis. (14729851)	Plawski A.... Sl/omski R.	2004	APC
25	Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent. (15492264)	Chen T.... Yeatman T.J.	2004	TP53, CDKN1A, CLU
26	Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes. (14970257)	Louie R.K.... Barth A.I.	2004	TUBE1
27	Cyclooxygenase 2 inhibitors and adenomatous polyposis coli (15239335)	Florent C.... Meary N.	2004	PTGS2
28	Regulation of caspase expression and apoptosis by adenomatous polyposis coli. (12907606)	Chen T.... Yeatman T.J.	2003	CASP3, CASP7, CASP9
29	Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. (12952568)	Clements W.M.... Groden J.	2003	CTNNB1
30	Adenomatous polyposis coli gene, beta-catenin, and E-cadherin expression in proximal and distal gastric cancers and precursor lesions: an immunohistochemical study using tissue microarrays. (12966349)	Gulmann C.... Kay E.	2003	CDH1, CTNNB1
31	Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas. (11935128)	Fransen K.... Sirsjo A.	2002	TP53, NOS2
32	Methylation of CpG loci in 5'-flanking region alters steady-state expression of adenomatous polyposis coli gene in colon cancer cell lines. (11135372)	Sakamoto Y.... Kitazawa S.	2001	APC
33	Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. (11466687)	Su L.K.... Vauthey J.N.	2001	APC
34	Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. (11487578)	Rubinfeld B.... Polakis P.	2001	APC, CTNNB1, AXIN1
35	Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. (11389840)	Liu J.... Matsunami N.	2001	TP53, APC, CTNNB1
36	Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. (11355321)	Kadmon M.... Herfarth C.	2001	APC
37	Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the adenomatous polyposis coli (APC) tumor suppressor gene. (11241666)	Jaiswal A.S.... Narayan S.	2001	APC, USF2, USF1
38	Beta-catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients. (10936679)	Akiyama Y.... Yuasa Y.	2000	CTNNB1
39	APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. (10646860)	Nakagawa H.... Nakamura Y.	2000	TP53BP2, APC2
40	Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein. (11050185)	Zhang F.... Neufeld K.L.	2000	PRKACA, APC
41	Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin. (10906131)	Hinoi T.... Kikuchi A.	2000	GSK3B, CTNNB1
42	Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. (11035805)	Neufeld K.L.... White R.L.	2000	APC
43	Deletion analysis of the adenomatous polyposis coli and PTCH gene loci in patients with sporadic and nevoid basal cell carcinoma syndrome-associated medulloblastoma. (10375116)	Vortmeyer A.O.... Zhuang Z.	1999	PTCH1
44	Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. (10021369)	Van Es J.H.... Clevers H.	1999	APC, CTNNB1, AXIN2
45	Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors. (10551328)	Nakagawa H.... Nakamura Y.	1999	APC2
46	Adenomatous polyposis coli protein is expressed in alternate stages of the ameloblast life cycle. (9839785)	Wang M.... Skobe Z.	1998	APC
47	Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. (8754807)	Munemitsu S.... Polakis P.	1996	CTNNB1
48	Cranial desmoid tumor associated with homozygous inactivation of the adenomatous polyposis coli gene in a 2-year-old girl with familial adenomatous polyposis. (8608492)	de Silva D.C.... Dunlop M.G.	1996	APC
49	Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene. (7833149)	Dobbie Z.... Scott R.J.	1994	APC
50	Identification of an alternative 5' untranslated region of the adenomatous polyposis coli gene. (8383094)	Lambertz S.... Ballhausen W.G.	1993	APC

Genes related to adenomatous polyposis coli according to GeneCards:

(show top 50)    (show all 135)

id	Symbol	Description	Score	GeneCards Section Context
1	APC2	adenomatosis polyposis coli 2	11.1	Proteins, Aliases & Descriptions, Orthologs, Publications (show all 5 sections) Domains & Families
2	APC	adenomatous polyposis coli	11.1	Orthologs, Domains & Families, Functions, Aliases & Descriptions (show all 7 sections) Publications, Transcripts, Databases
3	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.1	Summaries, Publications
4	MAPRE3	microtubule-associated protein, RP/EB family, member 3	11.1	Summaries, Publications
5	MAPRE2	microtubule-associated protein, RP/EB family, member 2	11.1	Publications, Summaries
6	MAPRE1	microtubule-associated protein, RP/EB family, member 1	11.1	Publications, Aliases & Descriptions
7	FAM123B	family with sequence similarity 123B	11.1	Aliases & Descriptions
8	SPATA13	spermatogenesis associated 13	11.1	Aliases & Descriptions
9	MIR135A1	microRNA 135a-1	11.0	Publications
10	MIR122	microRNA 122	11.0	Publications
11	PIH1D1	PIH1 domain containing 1	11.0	Orthologs
12	REEP5	receptor accessory protein 5	11.0	Publications
13	TUBE1	tubulin, epsilon 1	11.0	Publications
14	RDH5	retinol dehydrogenase 5 (11-cis/9-cis)	11.0	Publications
15	PPP1R15A	protein phosphatase 1, regulatory subunit 15A	11.0	Publications
16	PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	11.0	Publications
17	AXIN2	axin 2	11.0	Publications
18	AXIN1	axin 1	11.0	Publications
19	CTNNBIP1	catenin, beta interacting protein 1	11.0	Publications
20	TFF3	trefoil factor 3 (intestinal)	11.0	Publications
21	DVL1	dishevelled, dsh homolog 1 (Drosophila)	11.0	Publications
22	SIAH1	siah E3 ubiquitin protein ligase 1	11.0	Publications
23	USF2	upstream transcription factor 2, c-fos interacting	11.0	Publications
24	WNT1	wingless-type MMTV integration site family, member 1	11.0	Publications
25	MUTYH	mutY homolog (E. coli)	11.0	Publications
26	CCNB3	cyclin B3	11.0	Publications
27	MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	11.0	Publications
28	CSNK1E	casein kinase 1, epsilon	11.0	Publications
29	KLF4	Kruppel-like factor 4 (gut)	11.0	Publications
30	GADD45A	growth arrest and DNA-damage-inducible, alpha	11.0	Publications
31	SRP19	signal recognition particle 19kDa	11.0	Publications
32	ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	11.0	Publications
33	TP53BP2	tumor protein p53 binding protein, 2	11.0	Publications
34	PTGER1	prostaglandin E receptor 1 (subtype EP1), 42kDa	11.0	Publications
35	DHRS9	dehydrogenase/reductase (SDR family) member 9	11.0	Publications
36	POLB	polymerase (DNA directed), beta	11.0	Publications
37	USF1	upstream transcription factor 1	11.0	Publications
38	PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	11.0	Publications
39	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	11.0	Publications
40	FEN1	flap structure-specific endonuclease 1	11.0	Publications
41	H2AFX	H2A histone family, member X	11.0	Publications
42	SP3	Sp3 transcription factor	11.0	Publications
43	SCRIB	scribbled homolog (Drosophila)	11.0	Publications
44	RAN	RAN, member RAS oncogene family	11.0	Publications
45	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	11.0	Publications
46	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Publications
47	PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	11.0	Publications
48	KIFAP3	kinesin-associated protein 3	11.0	Publications
49	KIF2C	kinesin family member 2C	11.0	Publications
50	JUP	junction plakoglobin	11.0	Publications

Pathways related to adenomatous polyposis coli according to GeneDecks:

(show top 50)    (show all 164)

id	Pathway	Score	Top Affiliating Genes
1	Basal cell carcinoma20	10.7	AXIN2, APC, TCF7L2, APC2, TP53, PTCH1
2	Reelin Pathway (Cajal-Retzius cells)36	10.5	WNT1, PPP2R5A, PPP2CA, PPP2R5C, PPP2R5B, CTNNB1
3	Remodeling of Adherens Junctions36	10.5	UBC, CTNNA1, CDH1, CTNNB1, HGF, TUBE1
4	Human Embryonic Stem Cell Pluripotency36	10.4	WNT1, AXIN1, APC, HNF4A, DVL1, TCF4
5	Glioblastoma Multiforme36	10.3	CDC42, TCF4, TP53, CDK2, CDKN1A, AXIN1
6	Cell cycle_Role of APC in cell cycle regulation41	10.3	PRKACA, BUB3, BUB1, CCNB3, CCNA2, CCNB1
7	Cell cycle Role of APC in cell cycle regulation10	10.2	BUB1, BUB1B, BUB3, CDK2, MAD2L1, CCNB1
8	Oocyte meiosis20	10.2	CDK2, PPP2R5B, PGR, PRKACA, AR, PPP2R5A
9	Wnt / Hedgehog / Notch3	10.2	FAM123B, SCRIB, KLF4, PTCH1, APC, GSK3B
10	Wnt Signaling Pathway37	10.2	BTRC, CSNK1A1, AXIN2, GSK3B, APC, CTNNB1
11	Akt Signaling36	10.2	CCND1, CASP9, ATF4, HGF, GSK3B, PIK3CG
12	Adherens junction20	10.2	CTNNA1, CTNNB1, CTNND1, RHOA, ACP1, TCF7L2
13	Germ Cell-Sertoli Cell Junction Dynamics36	10.2	CDC42, TGFB1, CTNND1, CTNNA1, TUBE1, IQGAP1
14	Signal transduction_PTEN pathway41	10.1	CASP9, PCNA, GSK3B
15	Breast Cancer Regulation by Stathmin136	10.0	PPP1R15A, CCNB3, CCNB1, FGF2, ARHGEF4, CDC42
16	ATM Pathway36	10.0	GADD45A, H2AFX, TP53, CCNB3, CCNB1, ATF4
17	Colorectal cancer20	9.9	MSH2, TCF7L2, AXIN2, AXIN1, PIK3CG, GSK3B
18	Presenilin-Mediated Signaling36	9.9	BTRC, DVL1, CTNNB1, CTNNA1, CASP9, CDH2
19	Cell cycle Regulation of G1/S transition (part 1)10	9.9	CCND1, PPP2R5B, PPP2R5C, PPP2R5A, CDK2, GSK3B
20	Celecoxib Pathway, Pharmacodynamics34	9.8	PTGS2, PTGER1, PTGS1, DDIT3, CASP9, PLA2G2A
21	p53 signaling pathway20	9.8	CCNB3, TP53, SIAH1, GADD45A, CDKN1A, CDK2
22	Cell cycle_Regulation of G1/S transition (part 1)41	9.8	CDK2, BTRC, GSK3B, UBC, CDKN1A, PPP2CA
23	DNA damage ATM/ATR regulation of G1/S checkpoint10	9.7	MYC, CDK2, CCNA2, GADD45A
24	p53 Signaling36	9.7	BCL2, UBC, CASP3, TP53, CDKN1A, HIF1A
25	Cell cycle_ESR1 regulation of G1/S transition41	9.7	CDK2, ESR1, CCND1, CCNA2, CDKN1A, UBC
26	Cell cycle ESR1 regulation of G1/S transition10	9.7	CDKN1A, BTRC, MYC, XPO1, ESR1, CCND1
27	Wnt signaling pathway20	9.7	WNT1, CCND1, APC2, APC, GSK3B, AXIN2
28	Endometrial cancer20	9.6	AXIN1, CDH1, MLH1, MYC, PIK3CG, APC2
29	Transcription_Androgen Receptor nuclear signaling41	9.6	GSK3B, WNT1, PRKACA, DVL1, AR, CDKN1A
30	Transcription Androgen Receptor nuclear signaling10	9.6	PRKACA, TGFB1, DVL1, EGF, CCND1, GSK3B
31	GADD45 Pathway36	9.5	CDKN1A, CDK2, CCNB1, CCNA2, TP53, CCND1
32	Cyclins and Cell Cycle Regulation36	9.5	CDKN1A, CDK2, GSK3B, CCNB1, CCNA2, CCND1
33	ILK Signaling36	9.5	PPP2R5B, PPP2R5C, PPP2CA, PPP2R5A, EGF, HIF1A
34	DNA damage_ATM/ATR regulation of G1/S checkpoint41	9.3	TP53, CCND1, PCNA, UBC, CCNA2, MYC
35	Mismatch Repair in Eukaryotes36	9.3	MSH2, FEN1, RPA2, PMS1, PCNA, PMS2
36	Apoptosis Signaling Pathways37	9.3	AXIN1, BCL2, BIRC5, AXIN2, CASP9, CASP7
37	Epithelial Adherens Junctions36	9.3	TUBE1, PTPN13, CTNNA1, CTNNB1, CTNND1, EGF
38	G1-S Phase Transition36	9.2	CDKN1A, CDK2, GSK3B, CCNA2, CCND1, TP53
39	Signal transduction PTEN pathway10	9.2	GSK3B, CASP3, CASP9, CDKN1A, EGF, PCNA
40	WNT Signaling36	9.1	TP53, PTGS2, CTNNA1, CTNNB1, DVL1, TCF4
41	Cell Cycle, Mitotic38	9.1	CDKN1A, BUB1, BUB1B, TOP2A, BUB3, PCNA
42	Prostate cancer20	9.0	TP53, TCF7L2, CASP9, CCND1, AR, CDK2
43	GSK3 Signaling36	9.0	PPP2CA, PPP2R5C, PPP2R5B, CTNNB1, CTBP1, APC
44	Cell cycle20	8.9	TP53, TGFB1, PRKDC, GADD45A, CDK2, GSK3B
45	Small cell lung cancer20	8.8	CDK2, MYC, CCND1, RXRA, NOS2, PTGS2
46	Colorectal Cancer Metastasis36	8.4	TCF4, TGFB1, DVL1, EGF, CTNNB1, PTGS2
47	Pancreatic Adenocarcinoma36	8.2	FGF2, PTGS2, EGF, CCNB3, CCND1, CCNA2
48	Molecular Mechanisms of Cancer36	8.0	APC, FGF2, ARHGEF4, CDH1, CDK2, CDKN1A
49	Cell Cycle / Checkpoint Control3	7.5	CDK2, GADD45A, CSNK2A1, PRKDC, COPS5, RPA2
50	Pathways in cancer20	6.9	CDC42, BIRC5, BCL2, AXIN1, AXIN2, MSH2

Compounds related to adenomatous polyposis coli according to GeneDecks:

(show top 50)    (show all 306)

id	Compound	Score	Top Affiliating Genes
1	h2o232	10.3	PIK3CG, RAN, CLU, MUTYH, CCNB1, CASP9
2	egcg32	10.2	PIK3CG, CDK2, CASP9, PTGS1, DDIT3, CSNK2A1
3	rapamycin32 42	10.6	PIK3CG, ATF4, CDK2, AR, CCNB1, CCNA2
4	roscovitine32	9.5	PIK3CG, PCNA, BIRC5, CCNB1, CCNA2, IFI27
5	nocodazole32 42 9 9	12.5	PCNT, BUB1, BUB1B, RAN, BIRC5, CDKN1A
6	ns 39832 42	10.1	PIK3CG, PCNA, FGF2, CASP9, PTGER1, PTGS1
7	n acetylcysteine32	8.8	PCNA, BIRC5, CLU, ATF4, CDKN1A, CDH1
8	adpribose32	8.8	PIK3CG, PCNA, BIRC5, CDKN1A, CDK2, CCNB1
9	quercetin32 42 9 18 9	12.6	PIK3CG, BIRC5, BCL2, CDK2, AR, CCNB1
10	glycogen32 18	9.6	PIK3CG, BTRC, MYC, AXIN2, CDK2, CDH2
11	gefitinib32 34 9 9	11.6	PIK3CG, BIRC5, CDKN1A, CDK2, CDH1, FGF2
12	indole-3-carbinol32	8.6	BIRC5, BCL2, CDKN1A, CDK2, CDH1, AR
13	ly29400232	8.5	PIK3CG, CDC42, CDH1, FGF2, CCNA2, CCND1
14	geldanamycin32 9 9	10.4	PIK3CG, BIRC5, CDKN1A, CDK2, CDH1, AR
15	15-deoxy-delta-12,14-prostaglandin j232	8.4	PIK3CG, MYC, BMP6, BIRC5, CDKN1A, CDK2
16	sulindac32 9 9	10.4	PCNA, BIRC5, BCL2, CDKN1A, CDH1, MLH1
17	troglitazone32 42 9 9	11.3	PIK3CG, BMP6, BIRC5, BCL2, CDKN1A, CDK2
18	lactacystin32	8.3	PIK3CG, MYC, BIRC5, BCL2, CDKN1A, CDK2
19	bortezomib32 9 9	10.2	MYC, BIRC5, BCL2, ATF4, CDKN1A, CCND1
20	glutamate32	7.9	PCNA, BMP6, CLU, MSH2, CDK2, CDH2
21	estrogen32	7.8	PCNA, USF1, CLU, UBE3A, JUP, CDH2
22	docetaxel32 34 9 9	10.8	MYC, BIRC5, CLU, BCL2, CDKN1A, CDH1
23	adriamycin32	7.7	MYC, BIRC5, BCL2, MUC1, CDKN1A, CDH1
24	oxygen32 18	8.7	RAN, BIRC5, CLU, BCL2, MUTYH, ATF4
25	celecoxib32 42 34 9 18 9	12.7	PIK3CG, PCNA, BIRC5, BCL2, ATF4, CDKN1A
26	arsenite32 18	8.6	PIK3CG, PCNA, MYC, BIRC5, BCL2, ATF4
27	progesterone32 42 9 18 9	11.5	PCNA, BIRC5, CLU, BCL2, CDKN1A, CDK2
28	doxorubicin32 34 9 9	10.5	PIK3CG, BUB1B, BMP6, CLU, UBE3A, MSH2
29	indomethacin32 9 9	9.5	PCNA, MYC, BMP6, BIRC5, CDK2, CDH1
30	curcumin32	7.5	PIK3CG, MYC, BIRC5, BCL2, CDKN1A, CDK2
31	alanine32	7.5	PCNA, LMNA, MYC, BMP6, BIRC5, UBE3A
32	bromodeoxyuridine32	7.4	PCNA, MYC, BMP6, CDKN1A, CDK2, MLH1
33	testosterone32 9 18 9	10.4	PCNA, USF2, BIRC5, CLU, MUC1, CDK2
34	camptothecin32 42 9 9	10.2	PIK3CG, PCNA, MYC, BIRC5, CLU, BCL2
35	thymidine32 18	8.1	KLF4, PCNA, MYC, BMP6, BIRC5, CLU
36	gemcitabine32 34 9 9	10.0	PCNA, MYC, BIRC5, BCL2, MUC1, CDKN1A
37	mg 13232 42	7.8	PIK3CG, PCNA, MYC, BIRC5, CDKN1A, CDK2
38	phosphatidylinositol32	6.8	PIK3CG, MYC, BMP6, RAN, BIRC5, BCL2
39	resveratrol32 9 18 9	9.8	PIK3CG, PCNA, BIRC5, BCL2, CDKN1A, CDK2
40	retinoic acid32 42 18	8.8	PIK3CG, LMNA, MYC, BMP6, BIRC5, CLU
41	tamoxifen32 34 9 9	9.7	PCNA, MYC, BMP6, BIRC5, CLU, BCL2
42	5fluorouracil32	6.7	PIK3CG, PCNA, BIRC5, BCL2, MUC1, MSH2
43	butyrate32	6.6	KLF4, PCNA, MYC, BMP6, BIRC5, CLU
44	etoposide32 42 9 9	9.4	PIK3CG, PCNA, MYC, BIRC5, CLU, BCL2
45	vegf32	6.1	PIK3CG, PCNA, MYC, CLU, BCL2, MUC1
46	paclitaxel32 34 9 9	8.9	PIK3CG, PCNA, BUB1, BUB1B, MYC, BMP6
47	cisplatin32 34 9 9	8.9	PCNA, MYC, BMP6, RAN, BIRC5, CLU
48	tyrosine32	5.6	PIK3CG, KIFAP3, MYC, BMP6, RAN, BIRC5
49	dexamethasone32 42 34 9 9	9.5	PCNA, MYC, BMP6, BIRC5, CLU, BCL2
50	serine32	3.6	PIK3CG, BTRC, LMNA, MYC, BMP6, BIRC5

Cellular components related to adenomatous polyposis coli according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	Axin-APC-beta-catenin-GSK3B complex	GO:034747	10.9	CTNNBIP1, CTNNB1, APC, GSK3B, AXIN2, AXIN1
2	APC-Axin-1-beta-catenin complex	GO:034742	10.8	CTNNB1, APC, AXIN1
3	beta-catenin destruction complex	GO:030877	10.8	SIAH1, APC, GSK3B, AXIN1
4	cytoplasmic microtubule	GO:005881	10.7	MAPRE3, MAPRE1, APC2, APC, BIRC5, KIF2C
5	lateral plasma membrane	GO:016328	10.7	DVL1, CTNNB1, DLG1, APC, IQGAP1, CDH1
6	catenin complex	GO:016342	10.7	CTNNB1, CTNNA1, APC2, CDH1, CDH2, JUP
7	cell-cell adherens junction	GO:005913	10.6	CTNND1, CTNNB1, APC, CDH1, CDH2, JUP
8	kinetochore	GO:000776	10.6	MAD2L1, APC, XPO1, BUB3, BUB1B, BUB1
9	protein phosphatase type 2A complex	GO:000159	10.5	PPP2R5A, PPP2CA, PPP2R5C, PPP2R5B
10	cell-cell junction	GO:005911	10.4	CTNND1, CTNNB1, CTNNA1, DLG1, CDH2, JUP
11	lamellipodium	GO:030027	10.4	RHOA, CTNND1, CTNNA1, SPATA13, PTPN13, APC
12	microtubule	GO:005874	10.3	POLB, DLG1, TUBE1, TUBA4A, MAPRE3, MAPRE2
13	chromosome, centromeric region	GO:000775	10.2	PPP2R5A, PPP2CA, PPP2R5C, BIRC5, KIF2C
14	perinuclear region of cytoplasm	GO:048471	10.1	PTCH1, DLG1, CTNNB1, NOS2, PRKACA, ADCY10
15	midbody	GO:030496	10.1	RHOA, CTNND1, MAPRE3, IQGAP1, CDC42, BIRC5
16	transcription factor complex	GO:005667	10.1	HDAC9, PRKDC, TCF4, HIF1A, CTNNB1, CTBP1
17	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.0	CDKN1A, CDK2, CCND1
18	condensed chromosome kinetochore	GO:000777	10.0	CSNK1A1, MAD2L1, BIRC5, BUB3, BUB1B, BUB1
19	nuclear chromatin	GO:000790	10.0	H2AFX, RXRA, TP53, AR, MUC1, KLF4
20	centrosome	GO:005813	9.9	CSNK1A1, PRKACA, TFAP2A, CTNNB1, CCNB1, MAPRE1
21	cytosol	GO:005829	7.2	PCNT, KIF2C, KIFAP3, PIK3CG, ADCY10, PPP2R5B
22	nucleoplasm	GO:005654	7.1	RXRA, DDIT3, TP53, ESR1, HNF4A, CASP3
23	nucleolus	GO:005730	6.6	SPATA13, CTBP1, RPA2, COPS8, COPS5, HIF1A
24	cytoplasm	GO:005737	3.9	HIF1A, ACP1, COPS5, COPS3, COPS8, NOS2
25	nucleus	GO:005634	2.5	CTNNB1, CASP9, CASP3, CCNB3, CCND1, CCNA2

Biological processes related to adenomatous polyposis coli according to GeneDecks:

(show top 50)    (show all 79)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to indole-3-methanol	GO:071681	10.8	CTNNB1, CTNNA1, CDH1, JUP
2	M phase of mitotic cell cycle	GO:000087	10.6	MAD2L1, MAPRE1, XPO1, BIRC5, BUB3, BUB1B
3	mitotic cell cycle spindle assembly checkpoint	GO:007094	10.6	MAD2L1, APC, BUB3, BUB1B, BUB1
4	adherens junction organization	GO:034332	10.5	CTNND1, CTNNA1, CDH1, CDC42, CDH2, JUP
5	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	10.5	TCF7L2, CTNND1, DDIT3, FAM123B, MCC, APC2
6	mitotic prometaphase	GO:000236	10.5	CCNB1, MAD2L1, MAPRE1, XPO1, BIRC5, BUB3
7	canonical Wnt receptor signaling pathway	GO:060070	10.4	WNT1, TCF7L2, DVL1, CTNNB1, CCND1, APC
8	mitotic cell cycle spindle checkpoint	GO:071174	10.4	CSNK2A2, CSNK2A1, CCNB1
9	negative regulation of sequence-specific DNA binding transcription factor activity	GO:043433	10.4	TCF7L2, CTNNBIP1, DDIT3, PTCH1, ESR1, HNF4A
10	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051439	10.3	CCNB1, MAD2L1, CDK2, UBC, BTRC, BUB3
11	cellular component disassembly involved in apoptotic process	GO:006921	10.3	CTNNB1, CASP3, CASP7, APC, CDH1, LMNA
12	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:031145	10.3	CCNB1, MAD2L1, CDK2, UBC, BTRC, BUB3
13	G2/M transition of mitotic cell cycle	GO:000086	10.3	CCNA2, TUBA4A, PRKACA, CSNK1E, CCNB1, MAPRE1
14	regulation of protein localization to cell surface	GO:2000008	10.3	EGF, CTNNB1, CDH1
15	cell-cell adhesion	GO:016337	10.2	CTNND1, CTNNB1, DLG1, CDH1, JUP, SCRIB
16	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	10.2	WNT1, USP15, UBC, XPO1, TP53, PPP1R15A
17	positive regulation of apoptotic process	GO:043065	10.2	ADCY10, SIAH1, PRKDC, TOP2A, RXRA, CTNNB1
18	cell-cell junction organization	GO:045216	10.2	CDH2, CDH1, HNF4A, CTNNA1, CTNND1, TGFB1
19	Wnt receptor signaling pathway	GO:016055	10.1	DVL1, CSNK1A1, CSNK2A1, CSNK2A2, CSNK2B, WNT1
20	epithelial to mesenchymal transition	GO:001837	10.1	HGF, TGFB1, HIF1A, CTNNB1, GSK3B
21	negative regulation of mitotic cell cycle	GO:045930	10.1	TGFB1, DLG1, HNF4A, SCRIB, BCL2
22	phosphatidylinositol-mediated signaling	GO:048015	9.9	TOP2A, RHOA, CASP9, FEN1, GSK3B, BUB1B
23	base-excision repair	GO:006284	9.9	POLB, TP53, FEN1, MUTYH, PCNA
24	virus-host interaction	GO:019048	9.9	DLG1, CTBP1, RXRA, RHOA, TGFB1, TP53
25	aging	GO:007568	9.9	TGFB1, TOP2A, RXRA, CTNNA1, DDIT3, PTGS1
26	release of cytochrome c from mitochondria	GO:001836	9.9	TP53, CASP3, CASP7, BCL2, CLU, MYC
27	transforming growth factor beta receptor signaling pathway	GO:007179	9.9	TGFB1, RHOA, PPP1R15A, TP53, XPO1, UBC
28	mismatch repair	GO:006298	9.8	PMS2, MSH2, MUTYH, PCNA
29	cell cycle arrest	GO:007050	9.8	PPP1R15A, TGFB1, TCF7L2, GADD45A, DDIT3, TP53
30	mitosis	GO:007067	9.8	HGF, CSNK1A1, CCNA2, MAPRE3, MAPRE2, CDK2
31	cell proliferation	GO:008283	9.7	AR, MAPRE1, MAPRE2, TP53, TCF7L2, AXIN2
32	induction of apoptosis by intracellular signals	GO:008629	9.7	TP53, CASP9, CASP3, CASP7, CDKN1A, BCL2
33	branching involved in ureteric bud morphogenesis	GO:001658	9.7	WNT1, DLG1, FGF2, BCL2, MYC
34	negative regulation of cell proliferation	GO:008285	9.7	CTBP1, CTNNB1, PPP2R5C, RXRA, TGFB1, TFAP2A
35	cell division	GO:051301	9.6	MAPRE3, CCNB1, CCNA2, CCND1, CCNB3, RHOA
36	response to DNA damage stimulus	GO:006974	9.6	POLB, TOP2A, H2AFX, PPP1R15A, DDIT3, TP53
37	cell cycle checkpoint	GO:000075	9.6	RPA2, TP53, CCNB1, MAD2L1, CDK2, CDKN1A
38	negative regulation of transcription, DNA-dependent	GO:045892	9.5	CTBP1, CTNNB1, TGFB1, TFAP2A, TCF7L2, HDAC9
39	positive regulation of peptidyl-threonine phosphorylation	GO:010800	9.4	EGF, GSK3B, AXIN1, TGFB1
40	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.4	CTNNBIP1, RXRA, TGFB1, TFAP2A, TCF7L2, HDAC9
41	negative regulation of apoptotic process	GO:043066	9.4	MAD2L1, CASP3, TP53, CTNNA1, TFAP2A, WNT1
42	DNA repair	GO:006281	9.3	TOP2A, PRKDC, CSNK1E, POLB, GADD45A, H2AFX
43	response to drug	GO:042493	9.2	HNF4A, PTGS2, DDIT3, SRP19, CTNNB1, TOP2A
44	apoptotic process	GO:006915	9.1	CASP7, CASP3, CASP9, TP53, TP53BP2, CTNNB1
45	positive regulation of transcription, DNA-dependent	GO:045893	9.0	CTNNB1, SP3, TP53, HNF4A, EGF, HIF1A
46	blood coagulation	GO:007596	8.9	HGF, PRKACA, TGFB1, EGF, RHOA, NOS2
47	mitotic cell cycle	GO:000278	8.7	CSNK1E, UBC, BIRC5, BTRC, BUB3, BUB1B
48	G1/S transition of mitotic cell cycle	GO:000082	8.4	RPA2, CCND1, CCNB1, CDK2, CDKN1A, UBC
49	signal transduction	GO:007165	8.1	HIF1A, EGF, COPS3, PPP2R5A, DVL1, PRKACA
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	WNT1, PRKDC, TCF7L2, TCF4, GSK3B, AR

Molecular functions related to adenomatous polyposis coli according to GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	cadherin binding	GO:045296	10.7	CTNND1, CTNNB1, CTNNA1, APC, JUP
2	protein C-terminus binding	GO:008022	10.5	SIAH1, TCF4, TOP2A, PPP2CA, CTNNB1, CTBP1
3	gamma-catenin binding	GO:045295	10.5	TCF7L2, CTNNA1, APC, CDH1, CDH2
4	MutSalpha complex binding	GO:032407	10.5	PMS2, MLH1, MUTYH
5	microtubule binding	GO:008017	10.4	POLB, MAPRE3, MAPRE2, APC2, APC, BIRC5
6	alpha-catenin binding	GO:045294	10.4	CTNNB1, CDH2, JUP
7	protein dimerization activity	GO:046983	10.4	TFAP2A, PPP2CA, DDIT3, HNF1A, AR, ATF4
8	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive	GO:001077	10.3	TCF4, TFAP2A, HIF1A, TP53, HNF4A, HNF1A
9	double-stranded DNA binding	GO:003690	10.3	RXRA, CTNNB1, SP3, FEN1, MSH2, USF1
10	RNA polymerase II transcription factor binding	GO:001085	10.3	TP53, GSK3B, AR, KLF4
11	repressing transcription factor binding	GO:070491	10.1	HDAC9, CTNNB1, HNF4A, MYC
12	ubiquitin protein ligase binding	GO:031625	10.1	PRKACA, HIF1A, TP53, GSK3B, AXIN2, AXIN1
13	armadillo repeat domain binding	GO:070016	10.1	CTNNBIP1, AXIN1, TCF7L2
14	transcription regulatory region DNA binding	GO:044212	10.1	WNT1, TCF7L2, TFAP2A, HIF1A, RXRA, CTNNB1
15	protein phosphatase binding	GO:019903	10.1	RPA2, CTNND1, CTNNB1, IQGAP1, CDH1, CDH2
16	beta-catenin binding	GO:008013	10.1	BTRC, AXIN1, AXIN2, CDH2, CDH1, AR
17	MutLalpha complex binding	GO:032405	10.0	PCNA, MUTYH, MSH2
18	protein kinase binding	GO:019901	9.7	CCND1, CCNB3, TP53, DLG1, HIF1A, DVL1
19	protein serine/threonine kinase activity	GO:004674	9.5	CSNK2B, CSNK2A2, CSNK2A1, CSNK1E, CSNK1A1, PRKDC
20	transcription factor binding	GO:008134	9.4	HIF1A, TCF7L2, PRKDC, CSNK2B, HDAC9, CTNNB1
21	sequence-specific DNA binding	GO:043565	9.3	RXRA, HIF1A, TOP2A, TFAP2A, TCF7L2, PGR
22	sequence-specific DNA binding transcription factor activity	GO:003700	9.3	DDIT3, CTBP1, CTNNB1, RXRA, HIF1A, TCF4
23	protein kinase activity	GO:004672	9.3	CSNK1E, CSNK1A1, PRKDC, CCND1, CDK2, BUB1B
24	protein homodimerization activity	GO:042803	9.1	TFAP2A, TGFB1, TOP2A, NOS2, PTGS2, HNF4A
25	protein heterodimerization activity	GO:046982	9.1	RXRA, HIF1A, TOP2A, TGFB1, TCF4, HGF
26	enzyme binding	GO:019899	8.8	POLB, PGR, PRKDC, TGFB1, USF1, BIRC5
27	protein binding	GO:005515	0.5	CTNND1, TFAP2A, TCF4, TCF7L2, PRKDC, PRKACA