MCID: ADN027
MIFTS: 43

Adenomyosis malady

Rare diseases category
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Summaries for Adenomyosis

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Wikipedia:65 Adenomyosis (pronounced A - den - oh - my - oh - sis) is a medical condition characterized by the... more...

MalaCards based summary: Adenomyosis, also known as endometriosis of uterus, is related to endometriosis and endometrial carcinoma. An important gene associated with Adenomyosis is HOXA10 (homeobox A10), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and p75(NTR)-mediated signaling. The compounds ls-192629 and [thr4,gly7]ot have been mentioned in the context of this disorder. Affiliated tissues include uterus, endothelial and pituitary, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Adenomyosis

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Adenomyosis, Aliases & Descriptions:

Name: Adenomyosis 42
 
Endometriosis of Uterus 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Adenomyosis

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Diseases related to Adenomyosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis30.7CXCR1, OXTR, MMP7, EBAG9, HOXA10
2endometrial carcinoma30.2OXTR, MMP7, EBAG9, HOXA10
3adenocarcinoma30.1EBAG9, NGFR, MMP7, CXCR1, CGB
4cervical cancer29.6EBAG9, MMP7, HMOX2
5leukemia29.5CGB, CXCR1, NGFR, HOXA10
6breast cancer29.4NGFR, MMP7, OXTR, CGB
7leiomyoma10.7
8myoma10.5
9infertility10.5
10endotheliitis10.3
11uterine fibroid10.3
12atypical autism10.3OXTR, AVPR1A
13pregnancy loss10.2CGB, HOXA10
14endometrial stromal sarcoma10.2
15disseminated intravascular coagulation10.2
16endometrial adenocarcinoma10.2
17sarcoma10.2
18uterine disease10.2
19autistic disorder10.1AVPR1A, OXTR
20prolactinoma10.1NGFR, CGB
21clear cell adenocarcinoma10.1
22hyperprolactinemia10.1
23adenosarcoma10.1
24cervicitis10.1
25endometriosis of uterus10.1
26peritonitis10.1
27vaginitis10.1
28sepsis10.1
29hirschsprung's disease10.1HMOX2, NGFR
30lung small cell carcinoma10.0CXCR1, OXTR, NGFR
31factor v leiden thrombophilia10.0CGB, HMOX2, OXTR
32thrombocytopenia9.9
33renal agenesis9.9
34intravenous leiomyomatosis9.9
35hyperhomocysteinemia9.9
36endosalpingiosis9.9
37cerebritis9.9
38endocarditis9.9
39leiomyomatosis9.9
40leiomyosarcoma9.9
41mesenchymoma9.9
42thyroiditis9.9
43tuberculosis9.9
44adenosarcoma of the uterus9.9
45ectopic pregnancy9.9
46mayer-rokitansky-kuster-hauser syndrome9.9
47back pain9.9
48hypoxia9.9
49ischemia9.9AVPR1A, NGFR, CXCR1
50cholangiocarcinoma9.9CGB, MMP7, EBAG9

Graphical network of the top 20 diseases related to Adenomyosis:



Diseases related to adenomyosis

Symptoms for Adenomyosis

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Drugs & Therapeutics for Adenomyosis

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Drug clinical trials:

Search ClinicalTrials for Adenomyosis

Search NIH Clinical Center for Adenomyosis

Genetic Tests for Adenomyosis

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Anatomical Context for Adenomyosis

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MalaCards organs/tissues related to Adenomyosis:

32
Uterus, Endothelial, Pituitary, Cervix, Monocytes, Lymph node, Colon, Kidney, Thyroid, Breast, Testes

Animal Models for Adenomyosis or affiliated genes

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MGI Mouse Phenotypes related to Adenomyosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6HMOX2, OXTR, NGFR, AVPR1A
2MP:00053817.9HMOX2, MMP7, NGFR, HOXA10

Publications for Adenomyosis

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Articles related to Adenomyosis:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Significance of adenomyosis on tumor progression and survival outcome of endometrial cancer. (25001096)
2014
2
Abdominal Ultrasound-Guided Transvaginal Myometrial Core Needle Biopsy for the Definitive Diagnosis of Suspected Adenomyosis in 1032 Patients: A Retrospective Study. (25125243)
2014
3
Influences of uterine adenomyosis on muscle invasion and prognosis of endometrioid adenocarcinoma. (25188882)
2014
4
Adenomyosis and accompanying gynecological pathologies. (25280573)
2014
5
Serum differential proteomic analysis of endometriosis and adenomyosis by iTRAQ technique. (25233445)
2014
6
Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. (22999795)
2013
7
The disturbance of TH17-Treg cell balance in adenomyosis. (24331831)
2013
8
An unusual extremely distant noncommunicating uterine horn with myoma and adenomyosis treated with laparoscopic hemihysterectomy. (24109532)
2013
9
Clinical profiles of 710 premenopausal women with adenomyosis who underwent hysterectomy. (24148010)
2013
10
The significance of mean platelet volume on diagnosis and management of adenomyosis. (23348163)
2013
11
Effects of levonorgestrel-releasing intrauterine system and T380A intrauterine copper device on dysmenorrhea and days of bleeding in women with and without adenomyosis. (22832203)
2012
12
Uterine artery embolization to treat uterine adenomyosis with or without uterine leiomyomata: results of symptom control and health-related quality of life 40 months after treatment. (21850565)
2012
13
Uterine artery embolization for the treatment of adenomyosis: questions for long-term efficacy. (22365304)
2012
14
Differential immunohistochemical expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cow uteri with adenomyosis during follicular phase. (21626345)
2011
15
The utility of diffusion-weighted MR imaging in differentiation of uterine adenomyosis and leiomyoma. (21458180)
2011
16
Short-term results of magnetic resonance imaging-guided focused ultrasound surgery for patients with adenomyosis: symptomatic relief and pain reduction. (20970127)
2011
17
Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. (20932128)
2010
18
Uterine adenomyosis is associated with ultrastructural features of altered contractility in the inner myometrium. (19268938)
2010
19
Differences in mitochondrial proteins in the eutopic endometrium of patients with adenomyosis and endometriosis identified using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. (20819435)
2010
20
Adenomyosis to uterine transplantation. (20955093)
2010
21
Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy. (19232812)
2009
22
Adenomyosis a variant, not a disease? Evidence from hysterectomized menopausal women in the Study of Women's Health Across the Nation (SWAN). (18243177)
2009
23
Clinical application and midterm results of laparoscopic partial resection of symptomatic adenomyosis combined with uterine artery occlusion. (19249704)
2009
24
Intermediate and long term clinical effects of uterine arterial embolization with sodium alginate microspheres in treatment of diffuse adenomyosis]. (18843968)
2008
25
Clinical symptoms and histopathological findings in subjects with adenomyosis uteri. (18390081)
2008
26
The specific features of the expression of E-cadherin and beta-catenin in adenomyosis]. (19137776)
2008
27
Concomitant treatment of severe uterine adenomyosis in a premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist. (17222833)
2007
28
Adenomyosis: prevalence, risk factors, symptoms and clinical findings. (17937092)
2007
29
Altered apoptosis and proliferation in endometrial stromal cells of women with adenomyosis. (17208943)
2007
30
Radiofrequency ablation for cystic adenomyosis: a case report. (16779992)
2006
31
Predictive value of magnetic resonance imaging in differentiating between leiomyoma and adenomyosis. (16882423)
2006
32
Association of two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene with adenomyosis, endometriosis, and leiomyomata in Japanese women. (16725353)
2006
33
MRI of adenomyosis: changes with uterine artery embolization. (16498121)
2006
34
A rare case of completely separated rudimentary uterine horns with myoma and adenomyosis. (16527707)
2006
35
Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. (16410334)
2006
36
Combination of uterine adenomyosis with leiomyoma]. (16075610)
2005
37
Adenomyosis: what is the impact on fertility? (15870560)
2005
38
Interstitial pregnancy with huge adenomyosis uteri managed laparoscopically by using pre-operative and intra-operative imaging: case report. (16225584)
2005
39
New concepts on pathophysiology, diagnosis and treatment of adenomyosis]. (14968064)
2003
40
CD10 imunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis. (12766582)
2003
41
A matrix metalloproteinase inhibitor, ONO-4817, retards the development of mammary tumor and the progression of uterine adenomyosis in mice. (12553022)
2002
42
Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium. (11528364)
2001
43
Increased microvessel density in adenomyosis uteri. (11163827)
2001
44
Hysteroscopy and adenomyosis. (11791284)
2000
45
Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis. (10927050)
2000
46
Induction of endometriosis and adenomyosis by transvaginal pituitary transplantation in mice with and without natural killer cell activity. (9894569)
1998
47
Adenomyosis: current concepts and imaging considerations. (9456960)
1998
48
Bladder endometriosis: deep infiltrating endometriosis or adenomyosis? (9591511)
1998
49
Adenomyosis: diagnosis by hysteroscopic endomyometrial biopsy, correlation of incidence and severity with menorrhagia. (9798358)
1998
50
Integrin adhesion molecules in the endometrial glandular epithelium in patients with endometriosis or adenomyosis. (9392916)
1997

Variations for Adenomyosis

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Expression for genes affiliated with Adenomyosis

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Expression patterns in normal tissues for genes affiliated with Adenomyosis

Search GEO for disease gene expression data for Adenomyosis.

Pathways for genes affiliated with Adenomyosis

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Pathways related to Adenomyosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Peptide GPCRs37
9.2CXCR1, OXTR, AVPR1A
2
Show member pathways
9.1MMP7, NGFR

Compounds for genes affiliated with Adenomyosis

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Compounds related to Adenomyosis according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1ls-1926292810.2AVPR1A, OXTR
2[thr4,gly7]ot2810.2AVPR1A, OXTR
3ssr126768a2810.2AVPR1A, OXTR
4l0231032810.2AVPR1A, OXTR
5d(ch2)5[tyr(me)2,thr4,phe(3125i,4n3)-nh29]ovt2810.2AVPR1A, OXTR
6d(ch2)5[tyr(me)2,thr4,tyr(3125i)-nh29]ovt2810.2AVPR1A, OXTR
7opc-212682810.2AVPR1A, OXTR
8sr490594410.2AVPR1A, OXTR
9ovta4410.1AVPR1A, OXTR
10ssr1494152810.1AVPR1A, OXTR
11d(ch2)5[tyr(me)2]avp2810.1OXTR, AVPR1A
12davp2810.1OXTR, AVPR1A
13d[cha4]avp2810.1OXTR, AVPR1A
14d[leu4]avp2810.1OXTR, AVPR1A
15[3h]avp2810.1AVPR1A, OXTR
16d(ch2)5[tyr(me)2,thr4,tyr-nh29]ovt2810.1OXTR, AVPR1A
17[3h]ot (human, mouse, rat)2810.1OXTR, AVPR1A
18avt2810.1OXTR, AVPR1A
19d(ch2)5[tyr(me)2,thr4,phe(3i,4n3)-nh29]ovt2810.1OXTR, AVPR1A
20atosiban44 2811.1OXTR, AVPR1A
21sr 4905961 2811.1OXTR, AVPR1A
22vasopressin28 24 1112.0OXTR, AVPR1A
23oxytocin61 28 24 1113.0OXTR, AVPR1A
24desmopressin44 61 28 1112.9AVPR1A, OXTR
25estradiol44 24 1111.4HOXA10, OXTR, CGB
26prostaglandin449.2OXTR, MMP7, HOXA10
27phosphoinositide449.1CXCR1, OXTR, NGFR
28arachidonic acid44 28 24 1112.0CXCR1, OXTR, NGFR
29matrigel448.9NGFR, MMP7, CGB
30ribonucleic acid448.8HMOX2, OXTR, MMP7
31dopamine44 28 24 1111.8NGFR, OXTR, HMOX2
32leucine448.7OXTR, MMP7, NGFR
33superoxide44 249.5HMOX2, CXCR1, NGFR
34nitric oxide44 24 1110.3HMOX2, OXTR, MMP7, NGFR
35oligonucleotide448.3HOXA10, NGFR, MMP7, OXTR, CXCR1
36phosphatidylinositol448.2AVPR1A, NGFR, MMP7, OXTR, CXCR1
37glucose448.2NGFR, MMP7, HMOX2, CGB
38oxygen44 249.2HMOX2, CXCR1, MMP7, NGFR
39cysteine448.1AVPR1A, NGFR, MMP7, CXCR1, CGB
40vegf448.1NGFR, MMP7, OXTR, CXCR1, CGB
41progesterone44 28 61 24 1111.8HOXA10, NGFR, MMP7, OXTR, HMOX2, CGB
42calcium44 50 24 1110.5AVPR1A, NGFR, MMP7, OXTR, CXCR1, HMOX2
43estrogen447.4CGB, HOXA10, EBAG9, NGFR, MMP7, OXTR
44tyrosine447.3HOXA10, NGFR, MMP7, OXTR, CXCR1, KIR2DL3

GO Terms for genes affiliated with Adenomyosis

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Cellular components related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.8KIR2DL3, OXTR, NGFR, AVPR1A
2plasma membraneGO:0058867.1HMOX2, AVPR1A, EBAG9, NGFR, OXTR, CXCR1

Biological processes related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sperm ejaculationGO:0427139.7OXTR, AVPR1A
2social behaviorGO:0351769.7OXTR, AVPR1A
3maternal behaviorGO:0427119.6OXTR, AVPR1A
4telencephalon developmentGO:0215379.4OXTR, AVPR1A

Molecular functions related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:0170469.7OXTR, AVPR1A
2vasopressin receptor activityGO:0050009.4OXTR, AVPR1A

Products for genes affiliated with Adenomyosis

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Sources for Adenomyosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet