MCID: ADN027
MIFTS: 43

Adenomyosis malady

Rare diseases category

Summaries for Adenomyosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Adenomyosis (pronounced A - den - oh - my - oh - sis) is a medical condition characterized by the... more...

MalaCards: Adenomyosis, also known as endometriosis of uterus, is related to endometriosis and adenocarcinoma. An important gene associated with Adenomyosis is HOXA10 (homeobox A10), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and p75(NTR)-mediated signaling. The compounds ls-192629 and [thr4,gly7]ot have been mentioned in the context of this disorder. Affiliated tissues include uterus, pituitary and endothelial, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Adenomyosis

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Sources:
63UMLS, 44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

adenomyosis 44
endometriosis of uterus 63


Related Diseases for Adenomyosis

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18GeneCards, 19GeneDecks
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Diseases related to Adenomyosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis31.1CXCR1, OXTR, MMP7, EBAG9, HOXA10
2adenocarcinoma30.7EBAG9, NGFR, MMP7, CXCR1, CGB
3endometrial carcinoma30.4OXTR, MMP7, EBAG9, HOXA10
4cervical cancer29.8EBAG9, MMP7, HMOX2
5leukemia29.8CGB, CXCR1, NGFR, HOXA10
6breast cancer29.8NGFR, MMP7, OXTR, CGB
7leiomyoma10.7
8myoma10.5
9infertility10.5
10endotheliitis10.3
11uterine fibroid10.3
12endometrial stromal sarcoma10.2
13disseminated intravascular coagulation10.2
14endometrial adenocarcinoma10.2
15sarcoma10.2
16uterine disease10.2
17clear cell adenocarcinoma10.1
18hyperprolactinemia10.1
19adenosarcoma10.1
20cervicitis10.1
21endometriosis of uterus10.1
22vaginitis10.1
23sepsis10.1
24atypical autism10.1OXTR, AVPR1A
25pregnancy loss10.1CGB, HOXA10
26autistic disorder10.0AVPR1A, OXTR
27prolactinoma10.0NGFR, CGB
28hirschsprung's disease10.0HMOX2, NGFR
29lung small cell carcinoma10.0CXCR1, OXTR, NGFR
30factor v leiden thrombophilia10.0CGB, HMOX2, OXTR
31ischemia10.0AVPR1A, NGFR, CXCR1
32cholangiocarcinoma10.0CGB, MMP7, EBAG9
33idiopathic pulmonary fibrosis10.0MMP7, CXCR1
34stomach cancer10.0EBAG9, MMP7, CXCR1
35brain cancer10.0CGB, MMP7, NGFR
36osteosarcoma9.9NGFR, OXTR, CXCR1, CGB
37ulcerative colitis9.9NGFR, MMP7, CXCR1
38adenoma9.9CGB, MMP7, EBAG9
39hyperhomocysteinemia9.9
40ovarian endometriosis9.9
41renal agenesis9.9
42cerebritis9.9
43intravenous leiomyomatosis9.9
44endocarditis9.9
45leiomyomatosis9.9
46leiomyosarcoma9.9
47mesenchymoma9.9
48peritonitis9.9
49thrombocytopenia9.9
50thyroiditis9.9

Graphical network of the top 20 diseases related to Adenomyosis:



Diseases related to adenomyosis

Symptoms for Adenomyosis

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Drugs & Therapeutics for Adenomyosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenomyosis

Drug clinical trials:

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Search NIH Clinical Center for Adenomyosis

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Genetic Tests for Adenomyosis

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Anatomical Context for Adenomyosis

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34MalaCards
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MalaCards organs/tissues related to Adenomyosis:

34
Uterus, Pituitary, Endothelial, Cervix, Monocytes, Breast, Thyroid, Colon, Testes, Lymph node, Kidney

Animal Models for Adenomyosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adenomyosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6HMOX2, OXTR, NGFR, AVPR1A
2MP:00053817.9HMOX2, MMP7, NGFR, HOXA10

Publications for Adenomyosis

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53PubMed
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Articles related to Adenomyosis:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. (22999795)
2013
2
The disturbance of TH17-Treg cell balance in adenomyosis. (24331831)
2013
3
An unusual extremely distant noncommunicating uterine horn with myoma and adenomyosis treated with laparoscopic hemihysterectomy. (24109532)
2013
4
Clinical profiles of 710 premenopausal women with adenomyosis who underwent hysterectomy. (24148010)
2013
5
The significance of mean platelet volume on diagnosis and management of adenomyosis. (23348163)
2013
6
Adenomyosis in the bovine uterus: correlation between frequency, age, and 17I^-estradiol-progesterone equilibrium. (23122605)
2013
7
Effects of levonorgestrel-releasing intrauterine system and T380A intrauterine copper device on dysmenorrhea and days of bleeding in women with and without adenomyosis. (22832203)
2012
8
Uterine artery embolization to treat uterine adenomyosis with or without uterine leiomyomata: results of symptom control and health-related quality of life 40 months after treatment. (21850565)
2012
9
Uterine artery embolization for the treatment of adenomyosis: questions for long-term efficacy. (22365304)
2012
10
Differential immunohistochemical expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in cow uteri with adenomyosis during follicular phase. (21626345)
2011
11
The utility of diffusion-weighted MR imaging in differentiation of uterine adenomyosis and leiomyoma. (21458180)
2011
12
Short-term results of magnetic resonance imaging-guided focused ultrasound surgery for patients with adenomyosis: symptomatic relief and pain reduction. (20970127)
2011
13
Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. (20932128)
2010
14
Uterine adenomyosis is associated with ultrastructural features of altered contractility in the inner myometrium. (19268938)
2010
15
Differences in mitochondrial proteins in the eutopic endometrium of patients with adenomyosis and endometriosis identified using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. (20819435)
2010
16
Adenomyosis to uterine transplantation. (20955093)
2010
17
Suppression of migratory/invasive ability and induction of apoptosis in adenomyosis-derived mesenchymal stem cells by cyclooxygenase-2 inhibitors. (20227073)
2010
18
Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy. (19232812)
2009
19
Adenomyosis a variant, not a disease? Evidence from hysterectomized menopausal women in the Study of Women's Health Across the Nation (SWAN). (18243177)
2009
20
Clinical application and midterm results of laparoscopic partial resection of symptomatic adenomyosis combined with uterine artery occlusion. (19249704)
2009
21
Case report: Imaging of Mullerian adenosarcoma arising in adenomyosis. (19414090)
2009
22
Intermediate and long term clinical effects of uterine arterial embolization with sodium alginate microspheres in treatment of diffuse adenomyosis]. (18843968)
2008
23
Clinical symptoms and histopathological findings in subjects with adenomyosis uteri. (18390081)
2008
24
The specific features of the expression of E-cadherin and beta-catenin in adenomyosis]. (19137776)
2008
25
Concomitant treatment of severe uterine adenomyosis in a premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist. (17222833)
2007
26
Adenomyosis: prevalence, risk factors, symptoms and clinical findings. (17937092)
2007
27
Altered apoptosis and proliferation in endometrial stromal cells of women with adenomyosis. (17208943)
2007
28
Alcohol sclerotherapy for successful treatment of focal adenomyosis: a case report. (17390323)
2007
29
Radiofrequency ablation for cystic adenomyosis: a case report. (16779992)
2006
30
Predictive value of magnetic resonance imaging in differentiating between leiomyoma and adenomyosis. (16882423)
2006
31
Association of two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene with adenomyosis, endometriosis, and leiomyomata in Japanese women. (16725353)
2006
32
MRI of adenomyosis: changes with uterine artery embolization. (16498121)
2006
33
A rare case of completely separated rudimentary uterine horns with myoma and adenomyosis. (16527707)
2006
34
Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. (16410334)
2006
35
Adenomyosis in endometriosis--prevalence and impact on fertility. Evidence from magnetic resonance imaging. (16552093)
2006
36
Combination of uterine adenomyosis with leiomyoma]. (16075610)
2005
37
Adenomyosis: what is the impact on fertility? (15870560)
2005
38
Interstitial pregnancy with huge adenomyosis uteri managed laparoscopically by using pre-operative and intra-operative imaging: case report. (16225584)
2005
39
New concepts on pathophysiology, diagnosis and treatment of adenomyosis]. (14968064)
2003
40
CD10 imunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis. (12766582)
2003
41
A matrix metalloproteinase inhibitor, ONO-4817, retards the development of mammary tumor and the progression of uterine adenomyosis in mice. (12553022)
2002
42
Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium. (11528364)
2001
43
Endometrial carcinoma coexisting with pregnancy, presumed to derive from adenomyosis: a case report. (11906554)
2001
44
Hysteroscopy and adenomyosis. (11791284)
2000
45
Aberrant expression of glutathione peroxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis. (10927050)
2000
46
Induction of endometriosis and adenomyosis by transvaginal pituitary transplantation in mice with and without natural killer cell activity. (9894569)
1998
47
Adenomyosis: current concepts and imaging considerations. (9456960)
1998
48
Bladder endometriosis: deep infiltrating endometriosis or adenomyosis? (9591511)
1998
49
Adenomyosis: diagnosis by hysteroscopic endomyometrial biopsy, correlation of incidence and severity with menorrhagia. (9798358)
1998
50
Integrin adhesion molecules in the endometrial glandular epithelium in patients with endometriosis or adenomyosis. (9392916)
1997

Variations for Adenomyosis

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Expression for genes affiliated with Adenomyosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenomyosis

Search GEO for disease gene expression data for Adenomyosis.

Pathways for genes affiliated with Adenomyosis

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Adenomyosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Peptide GPCRs39
9.2CXCR1, OXTR, AVPR1A
2
Show member pathways
9.1MMP7, NGFR

Compounds for genes affiliated with Adenomyosis

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Sources:
30IUPHAR, 46Novoseek, 62Tocris Bioscience, 25HMDB, 12DrugBank, 52PharmGKB
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Compounds related to Adenomyosis according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1ls-1926293010.2AVPR1A, OXTR
2[thr4,gly7]ot3010.2AVPR1A, OXTR
3ssr126768a3010.2AVPR1A, OXTR
4l0231033010.2AVPR1A, OXTR
5d(ch2)5[tyr(me)2,thr4,phe(3125i,4n3)-nh29]ovt3010.2AVPR1A, OXTR
6d(ch2)5[tyr(me)2,thr4,tyr(3125i)-nh29]ovt3010.2AVPR1A, OXTR
7opc-212683010.2AVPR1A, OXTR
8sr490594610.2AVPR1A, OXTR
9ovta4610.1AVPR1A, OXTR
10ssr1494153010.1AVPR1A, OXTR
11d(ch2)5[tyr(me)2]avp3010.1OXTR, AVPR1A
12davp3010.1OXTR, AVPR1A
13d[cha4]avp3010.1OXTR, AVPR1A
14d[leu4]avp3010.1OXTR, AVPR1A
15[3h]avp3010.1AVPR1A, OXTR
16d(ch2)5[tyr(me)2,thr4,tyr-nh29]ovt3010.1OXTR, AVPR1A
17[3h]ot (human, mouse, rat)3010.1OXTR, AVPR1A
18avt3010.1OXTR, AVPR1A
19d(ch2)5[tyr(me)2,thr4,phe(3i,4n3)-nh29]ovt3010.1OXTR, AVPR1A
20atosiban46 3011.1OXTR, AVPR1A
21sr 4905962 3011.1OXTR, AVPR1A
22vasopressin30 25 1212.0OXTR, AVPR1A
23oxytocin62 30 25 1213.0OXTR, AVPR1A
24desmopressin46 62 30 1212.9AVPR1A, OXTR
25estradiol46 25 1211.4HOXA10, OXTR, CGB
26prostaglandin469.2OXTR, MMP7, HOXA10
27phosphoinositide469.1CXCR1, OXTR, NGFR
28arachidonic acid46 30 25 1212.0CXCR1, OXTR, NGFR
29matrigel468.9NGFR, MMP7, CGB
30ribonucleic acid468.8HMOX2, OXTR, MMP7
31dopamine46 30 25 1211.8NGFR, OXTR, HMOX2
32leucine468.7OXTR, MMP7, NGFR
33superoxide46 259.5HMOX2, CXCR1, NGFR
34nitric oxide46 25 1210.3HMOX2, OXTR, MMP7, NGFR
35oligonucleotide468.3HOXA10, NGFR, MMP7, OXTR, CXCR1
36phosphatidylinositol468.2AVPR1A, NGFR, MMP7, OXTR, CXCR1
37glucose468.2NGFR, MMP7, HMOX2, CGB
38oxygen46 259.2HMOX2, CXCR1, MMP7, NGFR
39cysteine468.1AVPR1A, NGFR, MMP7, CXCR1, CGB
40vegf468.1NGFR, MMP7, OXTR, CXCR1, CGB
41progesterone46 30 62 25 1211.8HOXA10, NGFR, MMP7, OXTR, HMOX2, CGB
42calcium46 52 25 1210.5AVPR1A, NGFR, MMP7, OXTR, CXCR1, HMOX2
43estrogen467.4CGB, HOXA10, EBAG9, NGFR, MMP7, OXTR
44tyrosine467.3HOXA10, NGFR, MMP7, OXTR, CXCR1, KIR2DL3

GO Terms for genes affiliated with Adenomyosis

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17Gene Ontology
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Cellular components related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.8KIR2DL3, OXTR, NGFR, AVPR1A
2plasma membraneGO:0058867.1HMOX2, AVPR1A, EBAG9, NGFR, OXTR, CXCR1

Biological processes related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sperm ejaculationGO:0427139.7OXTR, AVPR1A
2social behaviorGO:0351769.7OXTR, AVPR1A
3maternal behaviorGO:0427119.6OXTR, AVPR1A
4telencephalon developmentGO:0215379.4OXTR, AVPR1A

Molecular functions related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide hormone bindingGO:0170469.7OXTR, AVPR1A
2vasopressin receptor activityGO:0050009.4OXTR, AVPR1A

Products for genes affiliated with Adenomyosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenomyosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet