MCID: ADN027
MIFTS: 32

Adenomyosis malady

Summaries for Adenomyosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Adenomyosis (pronounced A - den - oh - my - oh - sis) is a medical condition characterized by the... more...

MalaCards: Adenomyosis, also known as endometriosis of uterus, is related to endometriosis and leiomyoma. An important gene associated with Adenomyosis is KIR2DL3 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3), and among its related pathways are Vasopressin-like receptors and Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q. The compounds estrogen and [thr4,gly7]ot have been mentioned in the context of this disorder. Affiliated tissues include uterus, and related mouse phenotypes are nervous system and cardiovascular system.

Aliases & Classifications for Adenomyosis

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Sources:
60UMLS, 42NIH Rare Diseases
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Aliases & Descriptions:

adenomyosis 42
endometriosis of uterus 60


Related Diseases for Adenomyosis

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17GeneCards, 18GeneDecks
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Diseases related to Adenomyosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis31.2TIMP2, ITGA5, OXTR, EBAG9, MUC16, HOXA10
2leiomyoma30.9OXTR
3adenocarcinoma30.8TIMP2, TIMP4, TIMP3, EBAG9, DNMT3B, NGFR
4endometrial carcinoma30.5TIMP2, EBAG9, DNMT3B, MUC16
5sarcoma30.2MMP7
6peritonitis30.0MUC16
7cervical cancer29.8TIMP3, EBAG9, MUC16, MMP7
8leukemia29.8ITGA5, DNMT3B, NGFR, HOXA10, CXCR1, KIR3DL1
9breast cancer29.8EBAG9, OXTR, TIMP3, TIMP4, TIMP2, DNMT3B
10myoma10.5
11infertility10.4
12uterine fibroid10.3
13endometrial adenocarcinoma10.2
14endometrial stromal sarcoma10.1
15disseminated intravascular coagulation10.1
16uterine disease10.1
17rare endometriosis10.1
18clear cell adenocarcinoma10.0
19hyperprolactinemia10.0
20adenosarcoma10.0
21cervicitis10.0
22endometriosis of uterus10.0
23vaginitis10.0
24neuroblastoma10.0NGFR
25arthritis10.0TIMP2, TIMP4, TIMP3, CXCR1
26cholangiocarcinoma10.0TIMP3, EBAG9, MMP7
27glioblastoma multiforme10.0TIMP2, TIMP3, OXTR, NGFR, MMP7, BECN1
28ischemia10.0NGFR, CXCR1, AVPR1A, PNOC, PTGIS
29adenoma10.0TIMP3, EBAG9, MMP7, PTGIS
30cervical squamous cell carcinoma10.0TIMP2
31hepatitis c10.0TIMP3, MMP7, KIR2DL3, KIR3DL1
32malignant glioma10.0NGFR, DNMT3B, TIMP2
33colorectal cancer10.0MMP7, MUC16, DNMT3B, EBAG9, TIMP3, TIMP2
34non-small cell lung carcinoma10.0TIMP2, TIMP3, OXTR, EBAG9, DNMT3B, MUC16
35rheumatoid arthritis10.0TIMP2, TIMP3, ITGA5, CXCR1, IL18BP, KIR3DL1
36lung cancer10.0TIMP2, OXTR, EBAG9, DNMT3B, MUC16, AVPR1A
37osteosarcoma10.0TIMP2, OXTR, NGFR, CXCR1
38colon cancer10.0TIMP3, DNMT3B, MMP7, BECN1
39ovarian cancer10.0TIMP2, TIMP3, EBAG9, DNMT3B, NGFR, MUC16
40acute leukemia10.0DNMT3B, CXCR1
41squamous cell carcinoma10.0TIMP2, TIMP3, EBAG9, DNMT3B, NGFR, MUC16
42melanoma10.0TIMP2, TIMP3, ITGA5, NGFR, CXCR1, IL18BP
43pancreatic cancer10.0MMP7, CXCR1, NGFR, EBAG9
44gastric adenocarcinoma10.0MMP7, MUC16, TIMP3, TIMP2
45stomach cancer10.0TIMP2, TIMP3, EBAG9, CXCR1, MMP7
46astrocytoma10.0NGFR, TIMP3
47myocardial infarction10.0PTGIS, MMP7
48hepatocellular carcinoma10.0TIMP2, TIMP3, ITGA5, EBAG9, DNMT3B, MMP7
49multiple sclerosis10.0TIMP3, NGFR, CXCR1, MMP7
50prostate cancer10.0TIMP2, TIMP4, TIMP3, OXTR, EBAG9, DNMT3B

Graphical network of the top 20 diseases related to Adenomyosis:



Diseases related to adenomyosis

Clinical Features for Adenomyosis

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Drugs & Therapeutics for Adenomyosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adenomyosis

Drug clinical trials:

Search ClinicalTrials for Adenomyosis

Search NIH Clinical Center for Adenomyosis

Search CenterWatch for Adenomyosis

Genetic Tests for Adenomyosis

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Anatomical Context for Adenomyosis

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32MalaCards
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MalaCards organs/tissues related to Adenomyosis:

32
Uterus

Animal Models for Adenomyosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenomyosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.4CALB1, ITGA5, OXTR, DNMT3B, NGFR, HOXA10
2MP:000538510.1BECN1, TIMP4, TIMP3, ITGA5, DNMT3B, NGFR

Publications for Adenomyosis

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Genetic Variations for Adenomyosis

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Expression for genes affiliated with Adenomyosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenomyosis

Search GEO for disease gene expression data for Adenomyosis.

Pathways for genes affiliated with Adenomyosis

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Adenomyosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5AVPR1A, OXTR
2
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10.5AVPR1A, CXCR1, OXTR
3
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10.5TIMP3, TIMP4
410.4TIMP2, TIMP3, ITGA5, MMP7
5
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10.4TIMP2, TIMP4, TIMP3, MMP7
6
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10.4NGFR, TIMP3, TIMP4, TIMP2
7
Cell adhesion ECM remodeling
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10.4MMP7, CXCR1, ITGA5, TIMP3, TIMP2
8
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10.4TIMP2, TIMP4, TIMP3, ITGA5, NGFR
9
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10.4TIMP2, TIMP4, TIMP3, ITGA5, NGFR
10
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10.4TIMP2, TIMP4, TIMP3, ITGA5, NGFR
11
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10.4TIMP2, TIMP4, TIMP3, ITGA5, NGFR
12
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10.4TIMP2, TIMP4, TIMP3, ITGA5, NGFR, MMP7

Compounds for genes affiliated with Adenomyosis

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Sources:
44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Adenomyosis according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9PNOC, HOXA10
2[thr4,gly7]ot2810.9OXTR, AVPR1A
3ssr126768a2810.9AVPR1A, OXTR
4ls-1926292810.9AVPR1A, OXTR
5l0231032810.9OXTR, AVPR1A
6d(ch2)5[tyr(me)2,thr4,tyr(3125i)-nh29]ovt2810.9OXTR, AVPR1A
7d(ch2)5[tyr(me)2,thr4,phe(3125i,4n3)-nh29]ovt2810.9OXTR, AVPR1A
8sr490594410.9OXTR, AVPR1A
9prostaglandin4410.9OXTR, HOXA10, MMP7, PNOC, PTGIS
101,10-phenanthroline44 211.9TIMP2, TIMP4, TIMP3, KIR3DL1
11ovta4410.9OXTR, AVPR1A
12opc-212682810.9OXTR, AVPR1A
13avt2810.9OXTR, AVPR1A
14d(ch2)5[tyr(me)2]avp2810.8AVPR1A, OXTR
15progesterone44 59 28 11 2414.8TIMP2, TIMP3, OXTR, NGFR, MUC16, HOXA10
16[3h]ot (human, mouse, rat)2810.8AVPR1A, OXTR
17vegf4410.8TIMP2, TIMP3, ITGA5, OXTR, NGFR, MUC16
18d(ch2)5[tyr(me)2,thr4,phe(3i,4n3)-nh29]ovt2810.8AVPR1A, OXTR
19nitric oxide44 11 2412.8TIMP2, CALB1, OXTR, NGFR, MMP7, PNOC
20oligonucleotide4410.8TIMP2, TIMP3, CALB1, OXTR, DNMT3B, NGFR
21d(ch2)5[tyr(me)2,thr4,tyr-nh29]ovt2810.8AVPR1A, OXTR
22steroid4410.8TIMP2, TIMP3, CALB1, OXTR, NGFR, MUC16
23d[leu4]avp2810.8OXTR, AVPR1A
24d[cha4]avp2810.8AVPR1A, OXTR
25[3h]avp2810.8AVPR1A, OXTR
26davp2810.8AVPR1A, OXTR
27calcium44 49 11 2413.8TIMP2, TIMP3, CALB1, ITGA5, OXTR, NGFR
28lipid4410.8TIMP2, TIMP3, OXTR, NGFR, CXCR1, KIR3DL1
29oxygen44 2411.8TIMP2, TIMP3, NGFR, CXCR1, MMP7, PTGIS
30ssr1494152810.8AVPR1A, OXTR
31glucose4410.8TIMP2, TIMP3, CALB1, NGFR, MUC16, MMP7
32tyrosine4410.8TIMP2, TIMP3, CALB1, ITGA5, OXTR, NGFR
33estradiol44 11 2412.8TIMP3, OXTR, MUC16, HOXA10
34batimastat44 59 1112.8MMP7, TIMP3, TIMP2
35atosiban28 4411.7AVPR1A, OXTR
36paraffin4410.7TIMP2, TIMP3, NGFR, MUC16, MMP7
375-aza-2deoxycytidine4410.7TIMP2, TIMP3, DNMT3B, KIR3DL1
38sr 4905959 2811.7AVPR1A, OXTR
39dexamethasone44 49 28 1113.7TIMP3, CALB1, OXTR, MUC16, CXCR1
40phosphatidylinositol4410.7TIMP3, OXTR, NGFR, CXCR1, AVPR1A, MMP7
41vasopressin28 11 2412.7AVPR1A, OXTR
42gaba4410.7CALB1, OXTR, NGFR, PNOC
43oxytocin28 59 11 2413.6AVPR1A, OXTR
44matrigel4410.6TIMP2, TIMP3, NGFR, MMP7
45ribonucleic acid4410.6TIMP2, TIMP3, OXTR, MMP7
46retinoic acid44 2411.5TIMP2, TIMP3, CALB1, NGFR, CXCR1, MMP7
47cysteine4410.4TIMP2, TIMP3, NGFR, CXCR1, AVPR1A, MMP7
48cholesterol44 28 11 2413.4BECN1, PTGIS, NGFR, OXTR, TIMP2
49testosterone44 59 11 2413.3TIMP3, CALB1, OXTR, MUC16, HOXA10
50(4-aminophenyl)mercuric acetate4410.2MMP7

GO Terms for genes affiliated with Adenomyosis

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16Gene Ontology
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Cellular components related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4PTGIS, MMP7, IL18BP, MUC16, TIMP4, TIMP2

Biological processes related to Adenomyosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cellular response to organic substanceGO:07131010.6CALB1, TIMP3, TIMP2
2response to drugGO:04249310.5BECN1, MMP7, OXTR, TIMP4, TIMP2
3response to cytokine stimulusGO:03409710.5TIMP2, TIMP4, OXTR
4sperm ejaculationGO:04271310.5AVPR1A, OXTR
5telencephalon developmentGO:02153710.5AVPR1A, OXTR
6maternal behaviorGO:04271110.4AVPR1A, OXTR
7central nervous system developmentGO:00741710.1TIMP2, TIMP4, NGFR

Molecular functions related to Adenomyosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:00819110.3TIMP3, TIMP4, TIMP2
2protein bindingGO:00551510.3NGFR, DNMT3B, ITGA5, CALB1, MUC16, HOXA10
3vasopressin receptor activityGO:00500010.2AVPR1A, OXTR

Products for genes affiliated with Adenomyosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenomyosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet