Aliases & Classifications for Adenosarcoma

MalaCards integrated aliases for Adenosarcoma:

Name: Adenosarcoma 12 51 41 14 69
Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1974
MeSH 41 D018195
NCIt 46 C9474
SNOMED-CT 64 189804002 31470003
UMLS 69 C0001442

Summaries for Adenosarcoma

Disease Ontology : 12 A carcinosarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary : Adenosarcoma, also known as mullerian adenosarcoma, is related to adenomyosis and cystadenoma. An important gene associated with Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Gastric cancer and LKB1 signaling events. The drugs Acetaminophen and Medroxyprogesterone acetate have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

Wikipedia : 72 Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign... more...

Related Diseases for Adenosarcoma

Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 adenomyosis 30.4 ESR1 PGR
2 cystadenoma 30.0 MME PGR
3 uterine carcinosarcoma 29.4 KIT PGR TP53
4 rhabdomyosarcoma 29.2 DES MB TP53
5 angiosarcoma 29.2 KIT TP53
6 gastrointestinal stromal tumor 28.9 DES KIT MKI67 TP53
7 endometrial adenocarcinoma 28.8 ESR1 MKI67 PGR TP53
8 smooth muscle tumor 28.8 DES ESR1 KIT MME PGR
9 uterine sarcoma 28.3 DES ESR1 KIT MB MME
10 adenosarcoma of the uterus 12.4
11 ovarian mesodermal adenosarcoma 12.3
12 uterine corpus adenosarcoma 12.2
13 cervical adenosarcoma 12.1
14 vaginal adenosarcoma 12.1
15 fallopian tube adenosarcoma 11.9
16 adenosarcoma of the cervix uteri 11.9
17 adenosarcoma of the corpus uteri 11.8
18 blastema predominant kidney wilms' tumor 10.9
19 epithelial predominant wilms' tumor 10.9
20 endometriosis 10.4
21 lymphangiomatosis 10.4 DES PGR
22 epulis 10.4 DES PGR
23 benign metastasizing leiomyoma 10.4 DES PGR
24 endometrial stromal nodule 10.4 MME PGR
25 ovarian fibrothecoma 10.4 DES KIT
26 spermatocele 10.4 MME PGR
27 malignant leydig cell tumor 10.4 KIT MME
28 gallbladder sarcoma 10.4 DES KIT
29 rete testis adenocarcinoma 10.4 KIT MME
30 breast myofibroblastoma 10.3 ESR1 MME
31 kidney benign neoplasm 10.3 KIT MME
32 rete testis neoplasm 10.3 KIT MME
33 malignant mixed mullerian tumor 10.3 KIT PGR
34 congenital epulis 10.3 DES PGR
35 breast angiosarcoma 10.3 KIT PGR
36 myxofibrosarcoma 10.3 DES MKI67
37 vulvar syringoma 10.3 ESR1 PGR
38 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
39 vulvar benign neoplasm 10.3 ESR1 PGR
40 trigonitis 10.3 ESR1 PGR
41 vulvar leiomyoma 10.3 ESR1 PGR
42 predominantly cortical thymoma 10.3 ESR1 PGR
43 syringoma 10.3 DES ESR1
44 breast medullary carcinoma 10.3 ESR1 PGR
45 breast scirrhous carcinoma 10.3 ESR1 PGR
46 progesterone resistance 10.3 ESR1 PGR
47 renal oncocytoma 10.3 KIT MME
48 progesterone-receptor positive breast cancer 10.3 ESR1 PGR
49 oncocytic breast carcinoma 10.3 ESR1 PGR
50 endometrial squamous cell carcinoma 10.3 ESR1 PGR

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to Adenosarcoma

Symptoms & Phenotypes for Adenosarcoma

GenomeRNAi Phenotypes related to Adenosarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.1 DES ESR1 KIT MB PGR TP53

MGI Mouse Phenotypes related to Adenosarcoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 DES TP53 ESR1 KIT MB PGR
2 homeostasis/metabolism MP:0005376 9.8 DES TP53 ESR1 KIT MB MME
3 embryo MP:0005380 9.72 PGR TP53 ESR1 KIT MB
4 integument MP:0010771 9.55 PGR TP53 ESR1 KIT MME
5 muscle MP:0005369 9.43 TP53 DES ESR1 KIT MB PGR
6 no phenotypic analysis MP:0003012 9.02 TP53 ESR1 KIT MKI67 PGR

Drugs & Therapeutics for Adenosarcoma

Drugs for Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 2 103-90-2 1983
2
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
3
Entinostat Investigational Phase 2 209783-80-2
4 Histone Deacetylase Inhibitors Phase 2,Phase 1
5 Antineoplastic Agents, Hormonal Phase 2
6 Contraceptive Agents Phase 2
7 Contraceptive Agents, Male Phase 2
8 Contraceptives, Oral Phase 2
9
Medroxyprogesterone Phase 2 520-85-4 10631
10
Belinostat Approved, Investigational Phase 1 866323-14-0
11
Fluorouracil Approved Phase 1 51-21-8 3385
12
Bevacizumab Approved, Investigational Phase 1 216974-75-3
13
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
14 Androgens Phase 1
15 Antimetabolites Phase 1
16 Antimetabolites, Antineoplastic Phase 1
17 Immunosuppressive Agents Phase 1
18 Albumin-Bound Paclitaxel Phase 1
19 Angiogenesis Inhibitors Phase 1
20 Angiogenesis Modulating Agents Phase 1
21 Antibodies Phase 1
22 Antibodies, Monoclonal Phase 1
23 Antimitotic Agents Phase 1
24 Antineoplastic Agents, Phytogenic Phase 1
25 Endothelial Growth Factors Phase 1
26 Immunoglobulins Phase 1
27 Mitogens Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer Active, not recruiting NCT03018249 Phase 2 Entinostat;Medroxyprogesterone Acetate
2 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
3 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1 oral belinostat
4 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Adenosarcoma

Cochrane evidence based reviews: adenosarcoma

Genetic Tests for Adenosarcoma

Anatomical Context for Adenosarcoma

MalaCards organs/tissues related to Adenosarcoma:

38
Uterus, Cervix, Ovary, Breast, Endothelial, Lung, Brain

Publications for Adenosarcoma

Articles related to Adenosarcoma:

(show top 50) (show all 249)
# Title Authors Year
1
Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. ( 29402239 )
2018
2
Uterine adenosarcoma in Japan: Clinicopathologic features, diagnosis and management. ( 29441675 )
2018
3
Uterine adenosarcoma with sarcomatous overgrowth: A case report of aggressive disease in a 16-year-old girl and a literature review. ( 29317258 )
2018
4
Embryo Cryopreservation Following In-Vitro Maturation for Fertility Preservation in a Woman with Mullerian Adenosarcoma: A Case Report. ( 28904505 )
2017
5
High-grade MA1llerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior. ( 28834809 )
2017
6
Significance of lymph node metastasis on survival of women with uterine adenosarcoma. ( 28109626 )
2017
7
A case of a primary hepatic so-called adenosarcoma with heterotopic ossification: possibly of biliary adenofibroma origin. ( 29079182 )
2017
8
Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma. ( 28154764 )
2017
9
MA1llerian Adenosarcoma of the Urinary Bladder: Clinicopathologic and Immunohistochemical Features With Novel Genetic Aberrations. ( 28690098 )
2017
10
Management of Low-Grade Cervical MA1llerian Adenosarcoma in a 14-Year-Old Girl. ( 28578185 )
2017
11
Treatment of Recurrent or Metastatic Uterine Adenosarcoma. ( 29445312 )
2017
12
Polypoid adenosarcoma of uterus with chondroid differentiation: A rare diagnosis. ( 29323096 )
2017
13
A Rare Case of Intramural MA1llerian Adenosarcoma Arising from Adenomyosis of the Uterus. ( 28741605 )
2017
14
MR Imaging of an Intramural Adenosarcoma with Pathologic Correlation. ( 28529247 )
2017
15
Ovarian metastasis of MA1llerian adenosarcoma of the cervix with sarcomatous overgrowth. ( 29085712 )
2017
16
Endometrial adenosarcoma in the setting of a germline DICER1 mutation: A case report. ( 28459098 )
2017
17
Uterine Adenosarcoma. ( 26927725 )
2016
18
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 27041653 )
2016
19
Genomewide copy number analysis of MA1llerian adenosarcoma identified chromosomal instability in the aggressive subgroup. ( 27255164 )
2016
20
A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth. ( 27867926 )
2016
21
Submucous uterine adenosarcoma-minimally invasive treatment. ( 27769260 )
2016
22
MA1llerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: A case report of aggressive disease in a young patient. ( 27621097 )
2016
23
Extensive Overgrowth of Sex Cord-Like Differentiation in Uterine Mullerian Adenosarcoma: A Rare and Challenging Entity. ( 26840033 )
2016
24
Involvement of Chromosome 8 in MA1llerian Adenosarcoma. ( 26974998 )
2016
25
Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth. ( 26722175 )
2016
26
Survival of women with Mullerian adenosarcoma: A National Cancer Data Base study. ( 27771166 )
2016
27
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034793 )
2016
28
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034795 )
2016
29
Role of dacarbazine in the treatment of recurrent mullerian adenosarcoma with sarcomatous overgrowth: Our experience. ( 27139896 )
2016
30
Hemoperitoneum due to breaking uterine adenosarcoma located in the omentum. Report of a case. ( 28003568 )
2016
31
Uterine Adenosarcoma: a Review. ( 27718181 )
2016
32
MA1llerian Adenosarcoma: A Malignant Progression of Adenomyosis? Pictorial Review With Multimodality Imaging. ( 26446823 )
2015
33
Advanced Mesodermal (MA1llerian) Adenosarcoma of the Ovary: Metastases to the Lungs, Mouth, and Brain. ( 26844003 )
2015
34
Uterine adenosarcoma with omentum metastasis complicated by a rapidly progressing liver abscess. ( 26166355 )
2015
35
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
36
Mullerian adenosarcoma of the uterus associated with tamoxifen treatment for breast cancer. ( 28913077 )
2015
37
Metanephric adenosarcoma: a rare case with immunohistochemistry and molecular analysis. ( 25267074 )
2014
38
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
39
Uterine adenosarcoma: an analysis on management, outcomes, and risk factors for recurrence. ( 25449308 )
2014
40
MA1llerian adenosarcoma: a review of cases and literature. ( 25556263 )
2014
41
A case of adenosarcoma of the uterus. ( 24592340 )
2014
42
Uterine Polyps With Features Overlapping With Those of MA1llerian Adenosarcoma: A Clinicopathologic Analysis of 29 Cases Emphasizing Their Likely Benign Nature. ( 25118811 )
2014
43
Adenosarcoma of the uterine body initially presenting as an interstitial small tumor of the uterus: a case report. ( 25118497 )
2014
44
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Mullerian Adenosarcoma of the Female Genital Tract. ( 25341585 )
2014
45
Extrauterine adenosarcoma arising in omental endometriosis: Rare site of occurrence of a rare tumor. ( 25308029 )
2014
46
Mullerian adenosarcoma of the cervix: Report of two large tumors with sarcomatous overgrowth or heterologous elements. ( 25426405 )
2014
47
Extragenital mA1llerian adenosarcoma in the pouch of douglas. ( 25207177 )
2014
48
Targeted genomic analysis of MA1llerian adenosarcoma. ( 25231023 )
2014
49
MA1llerian adenosarcoma arising from rectal endometriosis. ( 25360431 )
2014
50
MA1llerian adenosarcoma arising in a subserosal adenomyoma. ( 22820101 )
2013

Variations for Adenosarcoma

Expression for Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for Adenosarcoma

Pathways related to Adenosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 ESR1 KIT PGR TP53
2 10.88 ESR1 TP53
3 10.72 ESR1 TP53
4 10.5 ESR1 TP53

GO Terms for Adenosarcoma

Biological processes related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stem cell differentiation GO:0048863 9.16 ESR1 KIT
2 replicative senescence GO:0090399 8.96 MME TP53
3 positive regulation of phospholipase C activity GO:0010863 8.62 ESR1 KIT

Molecular functions related to Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.46 ESR1 MME PGR TP53
2 core promoter sequence-specific DNA binding GO:0001046 9.26 ESR1 TP53
3 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
4 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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