MCID: ADN020
MIFTS: 53

Adenosarcoma malady

Cancer diseases category
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Summaries for Adenosarcoma

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Disease Ontology:8 A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary: Adenosarcoma, also known as mullerian adenosarcoma, is related to adenofibroma and endometriosis. An important gene associated with Adenosarcoma is DES (desmin), and among its related pathways are Nuclear signaling by ERBB4 and FOXA1 transcription factor network. The compounds mucicarmine and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:65 Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign... more...

Aliases & Classifications for Adenosarcoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Adenosarcoma, Aliases & Descriptions:

Name: Adenosarcoma 8 10 44 62
 
Mullerian Adenosarcoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:1974
MeSH34 D018195
SNOMED-CT57 31470003, 189804002
NCIt39 C9474

Related Diseases for Adenosarcoma

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Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1adenofibroma31.0CALB2
2endometriosis31.0PGR, ESR1, ACTC1, CALB2
3cystadenoma30.7MME
4angiosarcoma30.6ACTC1, CALB2
5breast cancer30.5AR, ESR1, PGR
6rhabdomyosarcoma30.0WT1, MB, CALB2, ACTC1, DES
7ovarian cancer29.8PGR, ESR1, CALB2, WT1
8uterine sarcoma29.8DES, ESR1, MME, KIT, MB
9gastrointestinal stromal tumor29.7DES, MKI67, ACTC1, KIT
10smooth muscle tumor29.0MME, ACTC1, KIT, ESR1, PGR, MKI67
11adenocarcinoma29.0MKI67, PGR, ESR1, MME, ACTC1, CALB2
12sarcoma28.9DES, MKI67, ACTC1, CALB2, KIT, MB
13adenosarcoma of the uterus10.8
14infantile myofibromatosis10.6DES
15fasciitis10.5ACTC1
16alveolar soft part sarcoma10.5MB
17cerebral meningioma10.5PGR
18malignant peritoneal mesothelioma10.4CALB2
19epithelioid leiomyosarcoma10.4DES, ACTC1
20pseudosarcomatous fibromatosis10.4DES, ACTC1
21metanephric adenoma10.4WT1
22spindle cell sarcoma10.4DES, ACTC1
23carney triad10.4KIT
24ganglioglioma10.4CALB2
25cutaneous fibrous histiocytoma10.4DES, ACTC1
26fibrous histiocytoma10.4ACTC1, DES
27hemangiopericytoma10.4ACTC1, DES
28paraganglioma10.4ACTC1, DES
29leiomyomatosis10.4ESR1, PGR
30ductal carcinoma in situ10.4PGR, ESR1
31progesterone resistance10.4PGR, ESR1
32mammary paget's disease10.4PGR, ESR1
33giant cell tumor10.4DES, ACTC1
34bilateral breast cancer10.4PGR, ESR1
35ovarian mesodermal adenosarcoma10.3
36vaginal adenosarcoma10.3
37uterine corpus adenosarcoma10.3
38breast fibroadenoma10.3PGR, ESR1
39myoma10.3ESR1, PGR
40desmoplastic small round cell tumor10.3DES, WT1
41uterine fibroid10.3ESR1, PGR
42inflammatory breast carcinoma10.3ESR1, PGR
43fallopian tube adenosarcoma10.3
44cervical adenosarcoma10.3
45cervicitis10.3
46spindle cell carcinoma10.3DES, PGR, ACTC1
47endocrine gland cancer10.3ESR1, AR
48dedifferentiated liposarcoma10.3DES, KIT
49dilated cardiomyopathy10.3MB, ACTC1, DES
50li-fraumeni syndrome10.3PGR, ESR1

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to adenosarcoma

Symptoms for Adenosarcoma

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Drugs & Therapeutics for Adenosarcoma

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Drug clinical trials:

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Genetic Tests for Adenosarcoma

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Anatomical Context for Adenosarcoma

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MalaCards organs/tissues related to Adenosarcoma:

32
Uterus, Cervix, Ovary, Breast, Smooth muscle, Bone, Kidney, Liver, Lung, Testis

Animal Models for Adenosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Adenosarcoma:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7AR, KIT, ESR1, PGR
2MP:00053708.5ESR1, MME, KIT, WT1, AR
3MP:00107718.3PGR, ESR1, MME, KIT, AR
4MP:00053798.3PGR, ESR1, KIT, WT1, AR
5MP:00053808.2PGR, ESR1, KIT, MB, WT1, AR
6MP:00053978.1PGR, ESR1, KIT, MB, WT1, AR
7MP:00028738.0PGR, ACTC1, CALB2, KIT, WT1, AR
8MP:00053868.0DES, PGR, ESR1, CALB2, KIT, AR
9MP:00053847.8PGR, ESR1, ACTC1, KIT, MB, WT1
10MP:00053697.7AR, DES, PGR, ESR1, ACTC1, KIT
11MP:00053877.7PGR, ESR1, MME, KIT, WT1, AR
12MP:00053857.7DES, PGR, ESR1, ACTC1, KIT, MB
13MP:00107687.6DES, PGR, ESR1, ACTC1, KIT, MB
14MP:00053767.3DES, PGR, ESR1, MME, ACTC1, KIT

Publications for Adenosarcoma

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Articles related to Adenosarcoma:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. (25272296)
2014
2
Extragenital mA1llerian adenosarcoma in the pouch of douglas. (25207177)
2014
3
Serum CA125 changes in one case with malignant transformation from benign endometriosis to MA1llerian adenosarcoma. (24033977)
2013
4
Low-grade MA1llerian adenosarcoma with prominent decidualization, involving bilateral ovaries against a background of endometriosis: a diagnostic and treatment challenge. (23793320)
2013
5
MA1llerian adenosarcoma arising in a subserosal adenomyoma. (22820101)
2013
6
Primary ovarian adenosarcoma with elevated Ca-125 levels and normal ascitic fluid cytology: a case report and review of literature. (23304240)
2012
7
Mullerian adenosarcoma with sarcomatous overgrowth in the pelvic cavity extending into the inferior vena cava and the right atrium. (21707850)
2011
8
Extragenital MA1llerian adenosarcoma with pouch of Douglas location. (21575150)
2011
9
Mullerian adenosarcoma (heterologous) of the cervix with sarcomatous overgrowth: a case report with review of literature. (20613904)
2010
10
Mullerian adenosarcoma of the cervix in a 10-year-old girl: case report and review of the literature. (19493521)
2009
11
Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)
2009
12
Case report: Imaging of Mullerian adenosarcoma arising in adenomyosis. (19414090)
2009
13
Bone metastasis as the initial presentation in one case of ovarian cancer with two components of endometrioid adenocarcinoma and adenosarcoma. (19797025)
2009
14
A case of synchronous relapse of breast cancer and uterine mA1llerian adenosarcoma post tamoxifen in a premenopausal woman. (18386476)
2008
15
Mullerian adenosarcomas: an immunophenotypic analysis of 35 cases. (18469708)
2008
16
MA1llerian adenosarcoma of the ovary: case report and review of the literature. (17805167)
2007
17
Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. (17506376)
2007
18
Late recurrence of uterine Mullerian adenosarcoma as heterologous sarcoma: Three recurrences in 8 months increasing in number and grade of sarcomatous components. (16325895)
2006
19
Uterine adenosarcoma detected by Papanicolaou smear: a case report. (16783778)
2006
20
Gastrointestinal stromal tumor (GIST) with glandular component. A report of an unusual tumor resembling adenosarcoma. (16382991)
2005
21
Extrauterine mA1llerian adenosarcoma associated with endometriosis and rectal villotubular adenoma: report of a case and review of the literature. (15823126)
2005
22
Primary peritoneal adenosarcoma with stromal overgrowth and fetal type cartilage: a case report and literature review. (16083229)
2005
23
CD10, estrogen and progesterone receptor expression in ovarian adenosarcoma. (16051333)
2005
24
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma. (15571618)
2004
25
Adenosarcoma of the ovary. A case report. (15285316)
2004
26
A rare case of extrauterine adenosarcoma arising in endometriosis of the rectovaginal septum. (15066480)
2004
27
A case of ovarian adenosarcoma with a heterologous rhabdomyosarcoma component: a brief case report. (15474256)
2004
28
MA1llerian adenosarcoma of the cervix with heterologous elements: report of a case and review of the literature. (11748995)
2002
29
Uterine adenosarcoma with rhabdomyosarcomatous overgrowth. Brief communication. (11055503)
2000
30
Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. (11045336)
2000
31
Adenosarcoma of the uterine cervix presenting as a cervical polyp. (9736415)
1998
32
Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-beta1. (8608973)
1996
33
Primary gastric adenosarcoma. (8382916)
1993
34
Dedifferentiated extrauterine adenosarcoma responsive to chemotherapy. (8390963)
1993
35
CT of mullerian adenosarcoma arising in endometriosis. (8395963)
1993
36
MA1llerian adenosarcoma of uterus--a case report. (2559789)
1989
37
Infected mA1llerian adenosarcoma of the endometrium. (3031376)
1987
38
MA1llerian adenosarcoma with ovarian sex cord-like differentiation. A light- and electron-microscopic study. (3002598)
1986
39
Rhabdomyosarcomatous uterine adenosarcoma. (2991151)
1985
40
Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria. (6318673)
1983
41
Cervical mullerian adenosarcoma: case report. (6299743)
1982
42
Uterine MA1llerian adenosarcoma with psammoma bodies: cytologic, histologic and ultrastructural studies of a case. (6285654)
1982
43
Adenosarcoma of the ovary. A light- and electron-microscopic study with review of the literature. (6280945)
1982
44
Uterine adenosarcoma: report of a case with two further primary malignant tumors. (7215962)
1981
45
MA1llerian adenosarcoma of uterine cervix. Report of a case with rapidly fatal outcome. (6254739)
1980
46
MA1llerian adenosarcoma of the uterus: literature review, case report, and ultrastructural observations. (7233581)
1980
47
Adenosarcoma of the uterus: ultrastructural observations. (217264)
1979
48
MA1llerian adenosarcoma of the uterus with rapid progression: an ultrastructural study. (571831)
1979
49
MA1llerian adenosarcoma of the uterine cervix with heterologous elements: a light and electron microscopic study. (177174)
1976
50
MA1llerian adenosarcoma of the uterus. A clinicopathologic analysis of ten cases of a distinctive type of mA1llerian mixed tumor. (4371193)
1974

Variations for Adenosarcoma

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Expression for genes affiliated with Adenosarcoma

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Expression patterns in normal tissues for genes affiliated with Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for genes affiliated with Adenosarcoma

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Compounds for genes affiliated with Adenosarcoma

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Compounds related to Adenosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1mucicarmine449.8ACTC1, CALB2, DES
2anastrozole44 50 1111.6MKI67, PGR, ESR1
3norgestimate44 1110.6ESR1, AR, PGR
4adriamycin449.5MME, MB, PGR, DES
5nandrolone44 2410.5ESR1, PGR, AR
6exemestane44 50 61 1112.5PGR, ESR1, AR
7bisphenol a449.5ESR1, PGR, AR
8lapatinib44 50 1111.5AR, ESR1, PGR
9b 723449.4WT1, CALB2, DES, ACTC1
10danazol44 24 1111.4AR, PGR, ESR1
11levonorgestrel44 61 28 1112.4AR, PGR, ESR1
12progestin449.3ESR1, PGR, DES, AR
13flutamide44 61 1111.2AR, ESR1, PGR
14imatinib44 50 1111.2ACTC1, DES, KIT, WT1
15steroidal449.1PGR, AR, ESR1
16hyaluronic acid44 2410.1WT1, MB, CALB2, DES
17dihydrotestosterone44 28 24 1112.1AR, ESR1, PGR, DES
18formaldehyde44 2410.1KIT, MKI67, ACTC1, DES
19sodium dodecylsulfate449.1MKI67, DES, PGR, AR
20ribonucleic acid449.1WT1, KIT, MME, PGR, ACTC1
21geldanamycin44 50 61 1112.1PGR, ESR1, KIT, AR
22fulvestrant44 50 28 1112.0MKI67, ESR1, PGR, AR
23letrozole44 50 61 1112.0PGR, ESR1, MKI67, AR
2417beta-hydroxysteroid449.0ESR1, MKI67, AR, PGR
25progestins449.0MKI67, PGR, AR, ESR1
26mifepristone44 28 61 1112.0PGR, MKI67, AR, ESR1
27docetaxel44 50 61 1112.0KIT, ESR1, AR, PGR
28creatinine448.9WT1, DES, MB, ACTC1, MME
29hematoxylin448.9MKI67, ACTC1, KIT, CALB2, DES
30lactate448.8MB, DES, KIT, MME, MKI67
31actinomycin d448.8DES, KIT, AR, ESR1, MME
32gnrh448.7AR, MME, ESR1, PGR, MKI67
33estradiol44 24 1110.7MKI67, PGR, AR, ESR1, DES
34paclitaxel44 50 1110.6ESR1, CALB2, PGR, MKI67, KIT
35glutamine448.6MB, KIT, PGR, AR, WT1
36thymidine44 249.4KIT, CALB2, MME, DES, MKI67, WT1
37arginine448.4DES, MB, MME, WT1, AR, MKI67
38nitric oxide44 24 1110.3MME, DES, MKI67, WT1, KIT, CALB2
39cysteine448.3DES, PGR, MME, MB, WT1, KIT
40cycloheximide448.3AR, KIT, MME, ESR1, MKI67, PGR
41serine447.8MKI67, DES, KIT, MB, WT1, AR
42tyrosine447.4WT1, KIT, CALB2, ACTC1, MME, MKI67
43retinoic acid44 248.3DES, KIT, PGR, AR, ACTC1, WT1
44doxorubicin44 50 119.3MKI67, PGR, ESR1, MME, KIT, MB
45vegf447.0ESR1, WT1, DES, MB, KIT, ACTC1
46steroid446.8AR, WT1, KIT, CALB2, ACTC1, DES
47progesterone44 28 61 24 1110.8ACTC1, DES, MKI67, PGR, ESR1, MME
48estrogen446.8MKI67, PGR, ESR1, MME, ACTC1, CALB2
49testosterone44 61 24 119.5DES, MKI67, PGR, ESR1, MME, ACTC1
50paraffin446.5DES, MKI67, AR, WT1, MB, KIT

GO Terms for genes affiliated with Adenosarcoma

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Cellular components related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056547.9AR, CTDSP2, WT1, ESR1, PGR

Biological processes related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.9ACTC1, DES
2positive regulation of phospholipase C activityGO:0108639.5KIT, ESR1
3male gonad developmentGO:0085849.2WT1, KIT, ESR1
4transcription initiation from RNA polymerase II promoterGO:0063678.8PGR, ESR1, AR

Molecular functions related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.7ESR1, PGR
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.5AR, PGR
3enzyme bindingGO:0198998.8AR, ESR1, PGR
4zinc ion bindingGO:0082708.4PGR, ESR1, MME, WT1, AR
5protein bindingGO:0055156.4AR, DES, MKI67, PGR, ESR1, MME

Products for genes affiliated with Adenosarcoma

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Sources for Adenosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet