MCID: ADN020
MIFTS: 40

Adenosarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Adenosarcoma

Aliases & Descriptions for Adenosarcoma:

Name: Adenosarcoma 12 52 42 14 69
Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1974
MeSH 42 D018195
NCIt 47 C9474
SNOMED-CT 64 189804002 31470003
UMLS 69 C0001442

Summaries for Adenosarcoma

Disease Ontology : 12 A carcinosarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards based summary : Adenosarcoma, also known as mullerian adenosarcoma, is related to vaginal adenosarcoma and gastrointestinal stromal tumor. An important gene associated with Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Glioma and Signaling by ERBB4. The drugs Acetaminophen and Medroxyprogesterone acetate have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

Wikipedia : 71 Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign... more...

Related Diseases for Adenosarcoma

Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
id Related Disease Score Top Affiliating Genes
1 vaginal adenosarcoma 33.0 ESR1 MME PGR
2 gastrointestinal stromal tumor 29.5 DES KIT MKI67
3 adenosarcoma of the uterus 12.3
4 uterine corpus adenosarcoma 12.1
5 ovarian mesodermal adenosarcoma 12.0
6 cervical adenosarcoma 11.9
7 adenosarcoma of the cervix uteri 11.8
8 fallopian tube adenosarcoma 11.8
9 adenosarcoma of the corpus uteri 11.7
10 blastema predominant kidney wilms' tumor 10.7
11 epithelial predominant wilms' tumor 10.7
12 endometriosis 10.3
13 lymphomatous thyroiditis 10.3 DES PGR
14 papilloma 10.3 MME PGR
15 panophthalmitis 10.3 MME PGR
16 adult endodermal sinus tumor 10.3 DES PGR
17 biemond syndrome 10.2 DES PGR
18 skin angiosarcoma 10.2 KIT PGR
19 carbon monoxide-induced parkinsonism 10.2 DES KIT
20 testis sarcoma 10.2 DES KIT
21 trachea sarcoma 10.2 MME PGR
22 paranasal sinus cancer 10.2 KIT MME
23 ovarian embryonal carcinoma 10.2 KIT PGR
24 sphenoid sinus squamous cell carcinoma 10.2 KIT MME
25 mixed type rhabdomyosarcoma 10.2 DES MB
26 mesenchymoma 10.2 KIT PGR
27 glaucoma iridogoniodysgenesia 10.2 DES MB
28 verruciform xanthoma of skin 10.2 DES MB
29 intrahepatic bile duct cystadenoma 10.2 DES MB
30 bartholin's gland benign neoplasm 10.2 ESR1 PGR
31 cardiovascular organ benign neoplasm 10.2 ESR1 PGR
32 transitional cell carcinoma 10.2 DES MB
33 bronchus adenoma 10.2 ESR1 PGR
34 ovarian cystadenoma 10.2 DES MB
35 ovarian benign neoplasm 10.2 ESR1 PGR
36 plexiform neurofibroma 10.2 ESR1 PGR
37 gallbladder cancer 10.2 KIT MME
38 reticulohistiocytic granuloma 10.2 DES MB
39 foix-alajouanine syndrome 10.2 DES MKI67
40 paranasal sinus disease 10.2 ESR1 PGR
41 common bile duct neoplasm 10.2 MKI67 PGR
42 deafness, autosomal recessive 21 10.2 ESR1 PGR
43 factitious disorder 10.2 KIT MME
44 extracutaneous mastocytoma 10.2 DES MB
45 pediatric intraocular retinoblastoma 10.2 ESR1 PGR
46 congenital disorder of glycosylation, type ic 10.2 ESR1 PGR
47 breast angiomatosis 10.2 ESR1 MME
48 intestinal perforation 10.2 ESR1 PGR
49 perlman syndrome 10.2 ESR1 PGR
50 bone deterioration disease 10.2 DES MB

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to Adenosarcoma

Symptoms & Phenotypes for Adenosarcoma

GenomeRNAi Phenotypes related to Adenosarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.1 DES ERBB2 ESR1 KIT MB PGR

MGI Mouse Phenotypes related to Adenosarcoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 DES ERBB2 ESR1 KIT MB PGR
2 homeostasis/metabolism MP:0005376 9.7 KIT MB MME PGR DES ERBB2
3 embryo MP:0005380 9.65 ERBB2 ESR1 KIT MB PGR
4 integument MP:0010771 9.35 ERBB2 ESR1 KIT MME PGR
5 muscle MP:0005369 9.1 DES ERBB2 ESR1 KIT MB PGR

Drugs & Therapeutics for Adenosarcoma

Drugs for Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 2 103-90-2 1983
2
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
3 Histone Deacetylase Inhibitors Phase 2,Phase 1
4 Antineoplastic Agents, Hormonal Phase 2
5 Contraceptive Agents Phase 2
6 Contraceptive Agents, Male Phase 2
7 Contraceptives, Oral Phase 2
8
Entinostat Phase 2
9
Medroxyprogesterone Phase 2 520-85-4 10631
10
Belinostat Approved, Investigational Phase 1 866323-14-0
11
Fluorouracil Approved Phase 1 51-21-8 3385
12
Bevacizumab Approved, Investigational Phase 1 216974-75-3
13
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
14 Androgens Phase 1
15 Antimetabolites Phase 1
16 Antimetabolites, Antineoplastic Phase 1
17 Immunosuppressive Agents Phase 1
18 Albumin-Bound Paclitaxel Phase 1
19 Angiogenesis Inhibitors Phase 1
20 Angiogenesis Modulating Agents Phase 1
21 Antibodies Phase 1
22 Antibodies, Monoclonal Phase 1
23 Antimitotic Agents Phase 1
24 Antineoplastic Agents, Phytogenic Phase 1
25 Endothelial Growth Factors Phase 1
26 Immunoglobulin G Phase 1
27 Immunoglobulins Phase 1
28 Mitogens Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer Not yet recruiting NCT03018249 Phase 2
2 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1
3 Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma Completed NCT00413075 Phase 1
4 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Recruiting NCT02020707 Phase 1

Search NIH Clinical Center for Adenosarcoma

Cochrane evidence based reviews: adenosarcoma

Genetic Tests for Adenosarcoma

Anatomical Context for Adenosarcoma

MalaCards organs/tissues related to Adenosarcoma:

39
Uterus, Cervix, Ovary, Breast, Lung, Smooth Muscle, Brain

Publications for Adenosarcoma

Articles related to Adenosarcoma:

(show top 50) (show all 232)
id Title Authors Year
1
Involvement of Chromosome 8 in MA1llerian Adenosarcoma. ( 26974998 )
2016
2
MA1llerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: A case report of aggressive disease in a young patient. ( 27621097 )
2016
3
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034793 )
2016
4
Uterine Adenosarcoma. ( 26927725 )
2016
5
Extensive Overgrowth of Sex Cord-Like Differentiation in Uterine Mullerian Adenosarcoma: A Rare and Challenging Entity. ( 26840033 )
2016
6
Uterine Adenosarcoma: a Review. ( 27718181 )
2016
7
Genomewide copy number analysis of MA1llerian adenosarcoma identified chromosomal instability in the aggressive subgroup. ( 27255164 )
2016
8
Hemoperitoneum due to breaking uterine adenosarcoma located in the omentum. Report of a case. ( 28003568 )
2016
9
Role of dacarbazine in the treatment of recurrent mullerian adenosarcoma with sarcomatous overgrowth: Our experience. ( 27139896 )
2016
10
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 27041653 )
2016
11
Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth. ( 26722175 )
2016
12
Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature. ( 28034795 )
2016
13
A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth. ( 27867926 )
2016
14
Survival of women with Mullerian adenosarcoma: A National Cancer Data Base study. ( 27771166 )
2016
15
Submucous uterine adenosarcoma-minimally invasive treatment. ( 27769260 )
2016
16
Juvenile granulosa cell tumor arising in ovarian adenosarcoma: an unusual form of sarcomatous overgrowth. ( 25656930 )
2015
17
Advanced Mesodermal (MA1llerian) Adenosarcoma of the Ovary: Metastases to the Lungs, Mouth, and Brain. ( 26844003 )
2015
18
MA1llerian Adenosarcoma: A Malignant Progression of Adenomyosis? Pictorial Review With Multimodality Imaging. ( 26446823 )
2015
19
Uterine adenosarcoma with omentum metastasis complicated by a rapidly progressing liver abscess. ( 26166355 )
2015
20
Extrauterine adenosarcoma arising in omental endometriosis: Rare site of occurrence of a rare tumor. ( 25308029 )
2014
21
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Mullerian Adenosarcoma of the Female Genital Tract. ( 25341585 )
2014
22
A case of adenosarcoma of the uterus. ( 24592340 )
2014
23
MA1llerian Adenosarcoma of the Uterus With Low-grade Sarcomatous Overgrowth Characterized by Prominent Hydropic Change Resulting in Mimicry of a Smooth Muscle Tumor. ( 25272296 )
2014
24
MA1llerian adenosarcoma: a review of cases and literature. ( 25556263 )
2014
25
Uterine Polyps With Features Overlapping With Those of MA1llerian Adenosarcoma: A Clinicopathologic Analysis of 29 Cases Emphasizing Their Likely Benign Nature. ( 25118811 )
2014
26
Metanephric adenosarcoma: a rare case with immunohistochemistry and molecular analysis. ( 25267074 )
2014
27
Uterine adenosarcoma: an analysis on management, outcomes, and risk factors for recurrence. ( 25449308 )
2014
28
Targeted genomic analysis of MA1llerian adenosarcoma. ( 25231023 )
2014
29
Adenosarcoma of the uterine body initially presenting as an interstitial small tumor of the uterus: a case report. ( 25118497 )
2014
30
Mullerian adenosarcoma of the cervix: Report of two large tumors with sarcomatous overgrowth or heterologous elements. ( 25426405 )
2014
31
Extragenital mA1llerian adenosarcoma in the pouch of douglas. ( 25207177 )
2014
32
MA1llerian adenosarcoma arising from rectal endometriosis. ( 25360431 )
2014
33
Therapeutic effect of dienogest on adenosarcoma arising from endometriosis: a case report. ( 24324925 )
2013
34
Diagnosis and management of MA1llerian adenosarcoma of the uterine cervix. ( 23490428 )
2013
35
Serum CA125 changes in one case with malignant transformation from benign endometriosis to MA1llerian adenosarcoma. ( 24033977 )
2013
36
MA1llerian adenosarcoma: a frequently misinterpreted diagnosis. ( 24034536 )
2013
37
MA1llerian adenosarcoma arising in a subserosal adenomyoma. ( 22820101 )
2013
38
Low-grade MA1llerian adenosarcoma with prominent decidualization, involving bilateral ovaries against a background of endometriosis: a diagnostic and treatment challenge. ( 23793320 )
2013
39
Systemic therapy in advanced uterine adenosarcoma with sarcomatous overgrowth. ( 24333501 )
2013
40
Clinical benefit of trabectedin in uterine adenosarcoma. ( 23456619 )
2013
41
Osteoid differentiation in mesodermal (mullerian) adenosarcoma of ovary. ( 24126001 )
2013
42
Primary ovarian adenosarcoma with elevated Ca-125 levels and normal ascitic fluid cytology: a case report and review of literature. ( 23304240 )
2012
43
Uterine adenosarcoma in a patient with history of breast cancer and long-term tamoxifen consumption. ( 23087268 )
2012
44
Uterine adenosarcoma detected by conventional papanicolaou smear: A case report with emphasis on integrating the immunocytochemical staining. ( 21433006 )
2012
45
MA1llerian adenosarcoma of the uterus with heterologous elements: two case reports and literature review. ( 22382369 )
2012
46
Adenosarcoma ovarii in a 51-year-old woman: case report. ( 23185809 )
2012
47
MA1llerian adenosarcoma with a neuroectodermal component associated with an endometriotic cyst of the ovary: a case report. ( 22449231 )
2012
48
Uterine adenosarcoma metastasizing to the retroperitoneum. The impact of vascular involvement. ( 22802879 )
2012
49
Mullerian adenosarcoma of uterus with sarcomatous overgrowth and heterologous component associated with stromal deposit in omentum: a case report and review of the literature. ( 22952480 )
2012
50
Activity of pegylated liposomal doxorubicin for extragenital mullerian adenosarcoma with sarcomatous overgrowth: a case report and a review of the literature. ( 22053671 )
2011

Variations for Adenosarcoma

Expression for Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

GO Terms for Adenosarcoma

Biological processes related to Adenosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transduction by protein phosphorylation GO:0023014 9.16 ERBB2 KIT
2 stem cell differentiation GO:0048863 8.96 ESR1 KIT
3 positive regulation of phospholipase C activity GO:0010863 8.62 ESR1 KIT

Molecular functions related to Adenosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.16 ESR1 PGR
2 steroid binding GO:0005496 8.96 ESR1 PGR
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.62 ERBB2 KIT

Sources for Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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