MCID: ADN020
MIFTS: 52

Adenosarcoma malady

Cancer diseases category

Summaries for Adenosarcoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards: Adenosarcoma, also known as mullerian adenosarcoma, is related to endometriosis and adenofibroma. An important gene associated with Adenosarcoma is DES (desmin), and among its related pathways are Nuclear signaling by ERBB4 and FOXA1 transcription factor network. The compounds mucicarmine and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:66 Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign... more...

Aliases & Classifications for Adenosarcoma

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenosarcoma 9 11 46 63
mullerian adenosarcoma 9


External Ids:

Disease Ontology9 DOID:1974
MeSH36 D018195
SNOMED-CT59 189804002, 31470003
NCIt41 C9474

Related Diseases for Adenosarcoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis30.9PGR, ESR1, ACTC1, CALB2
2adenofibroma30.4CALB2
3breast cancer30.4AR, ESR1, PGR
4angiosarcoma30.2ACTC1, CALB2
5rhabdomyosarcoma30.1WT1, MB, CALB2, ACTC1, DES
6cystadenoma30.1MME
7adenocarcinoma30.0MKI67, PGR, ESR1, MME, ACTC1, CALB2
8sarcoma29.9DES, MKI67, ACTC1, CALB2, KIT, MB
9ovarian cancer29.9PGR, ESR1, CALB2, WT1
10uterine sarcoma29.9DES, ESR1, MME, KIT, MB
11gastrointestinal stromal tumor29.9DES, MKI67, ACTC1, KIT
12adenosarcoma of the uterus10.8
13vaginal adenosarcoma10.3
14uterine corpus adenosarcoma10.3
15cervicitis10.3
16fallopian tube adenosarcoma10.2
17ovarian mesodermal adenosarcoma10.2
18cervical adenosarcoma10.2
19peritonitis10.2
20vaginitis10.2
21adenosarcoma of the cervix uteri10.2
22infantile myofibromatosis10.1DES
23fasciitis10.1ACTC1
24alveolar soft part sarcoma10.1MB
25cerebral meningioma10.1PGR
26malignant peritoneal mesothelioma10.1CALB2
27epithelioid leiomyosarcoma10.1DES, ACTC1
28pseudosarcomatous fibromatosis10.1DES, ACTC1
29metanephric adenoma10.1WT1
30spindle cell sarcoma10.1DES, ACTC1
31carney triad10.1KIT
32ganglioglioma10.1CALB2
33cutaneous fibrous histiocytoma10.1DES, ACTC1
34fibrous histiocytoma10.1ACTC1, DES
35adenomyosis10.1
36adenosarcoma of the corpus uteri10.1
37hemangiopericytoma10.1ACTC1, DES
38glomus tumor10.1ACTC1, DES
39leiomyomatosis10.1ESR1, PGR
40ductal carcinoma in situ10.1PGR, ESR1
41progesterone resistance10.1PGR, ESR1
42mammary paget's disease10.1PGR, ESR1
43giant cell tumor10.1DES, ACTC1
44bilateral breast cancer10.1PGR, ESR1
45breast fibroadenoma10.1PGR, ESR1
46myoma10.1ESR1, PGR
47desmoplastic small round cell tumor10.1DES, WT1
48uterine fibroid10.1ESR1, PGR
49inflammatory breast carcinoma10.1ESR1, PGR
50spindle cell carcinoma10.1DES, PGR, ACTC1

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to adenosarcoma

Symptoms for Adenosarcoma

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Drugs & Therapeutics for Adenosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Adenosarcoma

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Genetic Tests for Adenosarcoma

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Anatomical Context for Adenosarcoma

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34MalaCards
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MalaCards organs/tissues related to Adenosarcoma:

34
Uterus, Cervix, Ovary, Breast, Bone, Smooth muscle, Kidney, Liver, Testis

Animal Models for Adenosarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adenosarcoma:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7AR, ESR1, PGR, KIT
2MP:00053708.5MME, KIT, WT1, AR, ESR1
3MP:00107718.3AR, KIT, ESR1, PGR, MME
4MP:00053798.3ESR1, AR, WT1, KIT, PGR
5MP:00053808.2KIT, WT1, MB, ESR1, PGR, AR
6MP:00053978.1KIT, WT1, ESR1, PGR, MB, AR
7MP:00028738.0ACTC1, CALB2, KIT, AR, PGR, WT1
8MP:00053868.0DES, PGR, AR, KIT, CALB2, ESR1
9MP:00053847.8PGR, ESR1, ACTC1, KIT, MB, WT1
10MP:00053697.7DES, AR, WT1, MB, KIT, ACTC1
11MP:00053877.7PGR, ESR1, AR, WT1, KIT, MME
12MP:00053857.7ACTC1, AR, WT1, MB, DES, KIT
13MP:00107687.6AR, MB, DES, ESR1, PGR, ACTC1
14MP:00053767.3AR, MB, ACTC1, WT1, ESR1, KIT

Publications for Adenosarcoma

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53PubMed
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Articles related to Adenosarcoma:

(show top 50)    (show all 199)
idTitleAuthorsYear
1
Serum CA125 changes in one case with malignant transformation from benign endometriosis to MA1llerian adenosarcoma. (24033977)
2013
2
Low-grade MA1llerian adenosarcoma with prominent decidualization, involving bilateral ovaries against a background of endometriosis: a diagnostic and treatment challenge. (23793320)
2013
3
MA1llerian adenosarcoma arising in a subserosal adenomyoma. (22820101)
2013
4
Primary ovarian adenosarcoma with elevated Ca-125 levels and normal ascitic fluid cytology: a case report and review of literature. (23304240)
2012
5
Uterine adenosarcoma metastasizing to the retroperitoneum. The impact of vascular involvement. (22802879)
2012
6
Mullerian adenosarcoma with sarcomatous overgrowth in the pelvic cavity extending into the inferior vena cava and the right atrium. (21707850)
2011
7
Extragenital MA1llerian adenosarcoma with pouch of Douglas location. (21575150)
2011
8
Mullerian adenosarcoma (heterologous) of the cervix with sarcomatous overgrowth: a case report with review of literature. (20613904)
2010
9
Mullerian adenosarcoma of the cervix in a 10-year-old girl: case report and review of the literature. (19493521)
2009
10
Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)
2009
11
Case report: Imaging of Mullerian adenosarcoma arising in adenomyosis. (19414090)
2009
12
Bone metastasis as the initial presentation in one case of ovarian cancer with two components of endometrioid adenocarcinoma and adenosarcoma. (19797025)
2009
13
A case of synchronous relapse of breast cancer and uterine mA1llerian adenosarcoma post tamoxifen in a premenopausal woman. (18386476)
2008
14
Mullerian adenosarcomas: an immunophenotypic analysis of 35 cases. (18469708)
2008
15
MA1llerian adenosarcoma of the ovary: case report and review of the literature. (17805167)
2007
16
Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. (17506376)
2007
17
Late recurrence of uterine Mullerian adenosarcoma as heterologous sarcoma: Three recurrences in 8 months increasing in number and grade of sarcomatous components. (16325895)
2006
18
Uterine adenosarcoma detected by Papanicolaou smear: a case report. (16783778)
2006
19
Gastrointestinal stromal tumor (GIST) with glandular component. A report of an unusual tumor resembling adenosarcoma. (16382991)
2005
20
Extrauterine mA1llerian adenosarcoma associated with endometriosis and rectal villotubular adenoma: report of a case and review of the literature. (15823126)
2005
21
Primary peritoneal adenosarcoma with stromal overgrowth and fetal type cartilage: a case report and literature review. (16083229)
2005
22
CD10, estrogen and progesterone receptor expression in ovarian adenosarcoma. (16051333)
2005
23
Immunohistochemical expression of CD10 antigen in uterine adenosarcoma. (15571618)
2004
24
Adenosarcoma of the ovary. A case report. (15285316)
2004
25
A rare case of extrauterine adenosarcoma arising in endometriosis of the rectovaginal septum. (15066480)
2004
26
A case of ovarian adenosarcoma with a heterologous rhabdomyosarcoma component: a brief case report. (15474256)
2004
27
MA1llerian adenosarcoma of the cervix with heterologous elements: report of a case and review of the literature. (11748995)
2002
28
Uterine adenosarcoma with rhabdomyosarcomatous overgrowth. Brief communication. (11055503)
2000
29
Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. (11045336)
2000
30
Adenosarcoma of the uterine cervix presenting as a cervical polyp. (9736415)
1998
31
Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-beta1. (8608973)
1996
32
Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen-associated endometrial lesions. (8811383)
1996
33
Primary gastric adenosarcoma. (8382916)
1993
34
Dedifferentiated extrauterine adenosarcoma responsive to chemotherapy. (8390963)
1993
35
CT of mullerian adenosarcoma arising in endometriosis. (8395963)
1993
36
MA1llerian adenosarcoma of uterus--a case report. (2559789)
1989
37
Infected mA1llerian adenosarcoma of the endometrium. (3031376)
1987
38
MA1llerian adenosarcoma with ovarian sex cord-like differentiation. A light- and electron-microscopic study. (3002598)
1986
39
Rhabdomyosarcomatous uterine adenosarcoma. (2991151)
1985
40
Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria. (6318673)
1983
41
Cervical mullerian adenosarcoma: case report. (6299743)
1982
42
Uterine MA1llerian adenosarcoma with psammoma bodies: cytologic, histologic and ultrastructural studies of a case. (6285654)
1982
43
Adenosarcoma of the ovary. A light- and electron-microscopic study with review of the literature. (6280945)
1982
44
Uterine adenosarcoma: report of a case with two further primary malignant tumors. (7215962)
1981
45
MA1llerian adenosarcoma of uterine cervix. Report of a case with rapidly fatal outcome. (6254739)
1980
46
MA1llerian adenosarcoma of the uterus: literature review, case report, and ultrastructural observations. (7233581)
1980
47
Adenosarcoma of the uterus: ultrastructural observations. (217264)
1979
48
MA1llerian adenosarcoma of the uterus with rapid progression: an ultrastructural study. (571831)
1979
49
MA1llerian adenosarcoma of the uterine cervix with heterologous elements: a light and electron microscopic study. (177174)
1976
50
MA1llerian adenosarcoma of the uterus. A clinicopathologic analysis of ten cases of a distinctive type of mA1llerian mixed tumor. (4371193)
1974

Variations for Adenosarcoma

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Expression for genes affiliated with Adenosarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for genes affiliated with Adenosarcoma

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51PathCards, 56Reactome, 39NCBI BioSystems Database
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Compounds for genes affiliated with Adenosarcoma

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Adenosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1mucicarmine469.8ACTC1, CALB2, DES
2anastrozole46 52 1211.6MKI67, PGR, ESR1
3norgestimate46 1210.6ESR1, AR, PGR
4adriamycin469.5MME, MB, PGR, DES
5nandrolone46 2510.5ESR1, PGR, AR
6exemestane46 52 62 1212.5PGR, ESR1, AR
7bisphenol a469.5ESR1, PGR, AR
8lapatinib46 52 1211.5AR, ESR1, PGR
9b 723469.4WT1, CALB2, DES, ACTC1
10danazol46 25 1211.4AR, PGR, ESR1
11levonorgestrel46 62 30 1212.4AR, PGR, ESR1
12progestin469.3ESR1, PGR, DES, AR
13flutamide46 62 1211.2AR, ESR1, PGR
14imatinib46 52 1211.2ACTC1, DES, KIT, WT1
15steroidal469.1PGR, AR, ESR1
16hyaluronic acid46 2510.1WT1, MB, CALB2, DES
17dihydrotestosterone46 30 25 1212.1AR, ESR1, PGR, DES
18formaldehyde46 2510.1KIT, MKI67, ACTC1, DES
19sodium dodecylsulfate469.1MKI67, DES, PGR, AR
20ribonucleic acid469.1WT1, KIT, MME, PGR, ACTC1
21geldanamycin46 52 62 1212.1PGR, ESR1, KIT, AR
22fulvestrant46 52 30 1212.0MKI67, ESR1, PGR, AR
23letrozole46 52 62 1212.0PGR, ESR1, MKI67, AR
2417beta-hydroxysteroid469.0ESR1, MKI67, AR, PGR
25progestins469.0MKI67, PGR, AR, ESR1
26mifepristone46 30 62 1212.0PGR, MKI67, AR, ESR1
27docetaxel46 52 62 1212.0KIT, ESR1, AR, PGR
28creatinine468.9WT1, DES, MB, ACTC1, MME
29hematoxylin468.9MKI67, ACTC1, KIT, CALB2, DES
30lactate468.8MB, DES, KIT, MME, MKI67
31actinomycin d468.8DES, KIT, AR, ESR1, MME
32gnrh468.7AR, MME, ESR1, PGR, MKI67
33estradiol46 25 1210.7MKI67, PGR, AR, ESR1, DES
34paclitaxel46 52 1210.6ESR1, CALB2, PGR, MKI67, KIT
35glutamine468.6MB, KIT, PGR, AR, WT1
36thymidine46 259.4KIT, CALB2, MME, DES, MKI67, WT1
37arginine468.4DES, MB, MME, WT1, AR, MKI67
38nitric oxide46 25 1210.3MME, DES, MKI67, WT1, KIT, CALB2
39cysteine468.3DES, PGR, MME, MB, WT1, KIT
40cycloheximide468.3AR, KIT, MME, ESR1, MKI67, PGR
41serine467.8MKI67, DES, KIT, MB, WT1, AR
42tyrosine467.4WT1, KIT, CALB2, ACTC1, MME, MKI67
43retinoic acid46 258.3DES, KIT, PGR, AR, ACTC1, WT1
44doxorubicin46 52 129.3MKI67, PGR, ESR1, MME, KIT, MB
45vegf467.0ESR1, WT1, DES, MB, KIT, ACTC1
46steroid466.8AR, WT1, KIT, CALB2, ACTC1, DES
47progesterone46 30 62 25 1210.8ACTC1, DES, MKI67, PGR, ESR1, MME
48estrogen466.8MKI67, PGR, ESR1, MME, ACTC1, CALB2
49testosterone46 62 25 129.5DES, MKI67, PGR, ESR1, MME, ACTC1
50paraffin466.5DES, MKI67, AR, WT1, MB, KIT

GO Terms for genes affiliated with Adenosarcoma

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17Gene Ontology
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Cellular components related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056547.9AR, CTDSP2, WT1, ESR1, PGR

Biological processes related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.9ACTC1, DES
2positive regulation of phospholipase C activityGO:0108639.5ESR1, KIT
3male gonad developmentGO:0085849.2ESR1, WT1, KIT
4transcription initiation from RNA polymerase II promoterGO:0063678.8AR, PGR, ESR1

Molecular functions related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.7ESR1, PGR
2ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.5PGR, AR
3enzyme bindingGO:0198998.8AR, ESR1, PGR
4zinc ion bindingGO:0082708.4ESR1, MME, WT1, AR, PGR
5protein bindingGO:0055156.4PGR, DES, MKI67, ESR1, MME, KIT

Products for genes affiliated with Adenosarcoma

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Sources for Adenosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet