MCID: ADN020
MIFTS: 49

Adenosarcoma malady

Summaries for Adenosarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards: Adenosarcoma, also known as mullerian adenosarcoma, is related to endometriosis and peritonitis. An important gene associated with Adenosarcoma is DES (desmin), and among its related pathways are PIP3 activates AKT signaling and Nuclear Receptor transcription pathway. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related mouse phenotypes are muscle and homeostasis/metabolism.

Wikipedia:63 Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign... more...

Aliases & Classifications for Adenosarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

adenosarcoma 8 10 44 60
mullerian adenosarcoma 8


External Ids:

Disease Ontology8 DOID:1974
NCIt39 C9474
SNOMED-CT56 31470003, 189804002
MeSH34 D018195

Related Diseases for Adenosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis30.7CALB2, PGR, ACTC1, ESR1
2peritonitis30.3MB
3breast cancer30.2AR, PGR, ESR1
4adenofibroma30.2CALB2
5adenocarcinoma30.1MKI67, CALB2, PGR, AR, ESR1, MME
6sarcoma30.1MKI67, DES, WT1, MB, CALB2, KIT
7uterine carcinosarcoma30.0KIT
8angiosarcoma30.0CALB2, ACTC1
9rhabdomyosarcoma30.0ACTC1, DES, WT1, MB, CALB2
10cystadenoma29.8MME
11adenoma29.8CALB2, ACTC1, MKI67
12endometrial carcinoma29.8PGR, MME, AR, ESR1
13ovarian cancer29.8WT1, PGR, ESR1, CALB2
14gastrointestinal stromal tumor29.8ACTC1, KIT, MKI67, DES
15cervical adenosarcoma10.4
16adenosarcoma of the uterus10.3
17uterine corpus adenosarcoma10.3
18vaginal adenosarcoma10.3
19cervicitis10.2
20fallopian tube adenosarcoma10.2
21ovarian mesodermal adenosarcoma10.2
22vaginitis10.2
23adenosarcoma of the cervix uteri10.2
24adenosarcoma of the corpus uteri10.0
25hemangioma10.0ACTC1
26chordoma10.0DES
27papilloma10.0ACTC1
28infantile myofibromatosis10.0DES
29glomerulonephritis10.0MME
30fasciitis10.0ACTC1
31congestive heart failure10.0MME
32lipoma10.0DES
33hypertrophic cardiomyopathy10.0ACTC1
34deficiency anemia10.0MME
35osteosarcoma10.0ESR1
36hypertension10.0MME
37leydig cell tumor10.0CALB2
38pheochromocytoma10.0CALB2
39thymoma10.0CALB2
40cerebral meningioma10.0PGR
41colon cancer10.0CALB2
42nephroblastoma10.0WT1
43malignant fibroxanthoma10.0MB
44arthritis10.0MB
45azoospermia10.0AR
46prostatic hypertrophy10.0AR
47germ cell cancer10.0AR
48myoepithelioma10.0ACTC1
49eosinophilia10.0MB
50epithelioid leiomyosarcoma10.0ACTC1, DES

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to adenosarcoma

Clinical Features for Adenosarcoma

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Drugs & Therapeutics for Adenosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Adenosarcoma

Drug clinical trials:

Search ClinicalTrials for Adenosarcoma

Search NIH Clinical Center for Adenosarcoma

Search CenterWatch for Adenosarcoma

Genetic Tests for Adenosarcoma

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Anatomical Context for Adenosarcoma

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32MalaCards
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MalaCards organs/tissues related to Adenosarcoma:

32
Uterus, Cervix, Ovary, Breast, Lung, Liver, Kidney, Smooth muscle, Testis, Bone

Animal Models for Adenosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.3ESR1, ACTC1, WT1, MB
2MP:00053768.5MB, AR, DES, PGR, ACTC1, ESR1
3MP:00053708.3WT1, AR, MME, KIT, ESR1
4MP:00053808.1MB, WT1, AR, PGR, KIT, ESR1
5MP:00053847.8WT1, AR, PGR, KIT, ACTC1, ESR1
6MP:00053857.6MB, WT1, AR, DES, PGR, KIT
7MP:00028737.6CALB2, WT1, AR, PGR, KIT, ACTC1
8MP:00107687.2MB, WT1, AR, DES, PGR, KIT

Publications for Adenosarcoma

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50PubMed
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Articles related to Adenosarcoma:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
MA1llerian adenosarcoma arising in a subserosal adenomyoma. (22820101)
2013
2
Diagnosis and management of MA1llerian adenosarcoma of the uterine cervix. (23490428)
2013
3
Systemic therapy in advanced uterine adenosarcoma with sarcomatous overgrowth. (24333501)
2013
4
Extragenital MA1llerian adenosarcoma with pouch of Douglas location. (21575150)
2011
5
So-called 'adenosarcoma' of the kidney a novel adult renal tumor with a cystic appearance. (21501298)
2011
6
Clinicopathological analysis of mullerian adenosarcoma of the uterus. (20368100)
2010
7
Recurrent mullerian adenosarcoma like tumor of seminal vesicle. (20551553)
2010
8
Mullerian adenosarcoma of the female genital tract. (20179434)
2010
9
Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility. (21319526)
2010
10
Mullerian adenosarcoma of the cervix in a 10-year-old girl: case report and review of the literature. (19493521)
2009
11
Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. (18941402)
2009
12
A case of synchronous relapse of breast cancer and uterine mA1llerian adenosarcoma post tamoxifen in a premenopausal woman. (18386476)
2008
13
Ovarian adenosarcoma with extensive deciduoid morphology arising in endometriosis: a case report. (18580317)
2008
14
Robotically assisted total laparoscopic radical trachelectomy for fertility sparing in stage IB1 adenosarcoma of the cervix. (18803518)
2008
15
Endometrial adenosarcoma. (18936003)
2008
16
Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. (17506376)
2007
17
Surgical conservation of both ovaries in an adolescent with uterine mA1llerian adenosarcoma: a case report. (17478375)
2007
18
Mullerian adenosarcoma of uterine cervix: report of three cases and review of literature. (17292949)
2007
19
Late recurrence of uterine Mullerian adenosarcoma as heterologous sarcoma: Three recurrences in 8 months increasing in number and grade of sarcomatous components. (16325895)
2006
20
Extrauterine mA1llerian adenosarcoma associated with endometriosis and rectal villotubular adenoma: report of a case and review of the literature. (15823126)
2005
21
Uterine adenosarcoma in a boy with persistent mA1llerian duct syndrome: first reported case. (16150330)
2005
22
Adenosarcoma of the ovary. A case report. (15285316)
2004
23
Endometriosis of the liver containing mullerian adenosarcoma: case report. (15547552)
2004
24
MA1llerian adenosarcoma arising from the uterine cervix. (14995932)
2004
25
Immunohistochemical determination of estrogen and progesterone receptor positivity in uterine adenosarcoma. (15196864)
2004
26
Mesodermal (mA1llerian) adenosarcoma of the ovary: a clinicopathologic analysis of 40 cases and a review of the literature. (12360039)
2002
27
MA1llerian adenosarcoma of the uterus: report of a case with imprint cytology. (11480728)
2001
28
Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. (11045336)
2000
29
MA1llerian adenosarcoma of the uterus in association with tamoxifen therapy. (10681194)
2000
30
Vaginal adenosarcoma arising from endometriosis. (10620454)
2000
31
Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience. (9625851)
1998
32
Extraendometrial mullerian adenosarcoma. (12179665)
1998
33
Primary extrauterine mullerian adenosarcoma of the peritoneum. (8631563)
1996
34
Two unusual presentations of mA1llerian adenosarcoma: case reports, literature review, and treatment considerations. (8522267)
1995
35
Primary extrauterine mA1llerian adenosarcoma of the peritoneum. (7705694)
1995
36
An unusual extrauterine variant of adenosarcoma with multiple recurrences over 16 years. (8175015)
1994
37
CT of mullerian adenosarcoma arising in endometriosis. (8395963)
1993
38
Uterine mA1llerian adenosarcoma with histiocytic (xanthomatous) mesenchymal component. (1667278)
1991
39
MA1llerian adenosarcoma of the uterus with pure angiosarcoma: case report. (1660853)
1991
40
MA1llerian adenosarcoma of uterus--a case report. (2559789)
1989
41
Adenosarcoma uteri. (3039786)
1987
42
MA1llerian adenosarcoma with ovarian sex cord-like differentiation. A light- and electron-microscopic study. (3002598)
1986
43
Uterine MA1llerian adenosarcoma with psammoma bodies: cytologic, histologic and ultrastructural studies of a case. (6285654)
1982
44
MA1llerian adenosarcoma of the uterine cervix. (6268525)
1981
45
MA1llerian adenosarcoma of the uterus. Clinicopathologic report of five cases. (532851)
1979
46
Adenosarcoma of uterus and ovary: a clinicopathologic study of two cases. (221090)
1979
47
Extrauterine MA1llerian adenosarcoma; a clinicopathologic report of a case with distant metastases and review of the literature. (208932)
1978
48
Synchronous double primary lymphosarcoma and adenosarcoma (collision tumor) of the stomach with cancer-to-cancer metastasis. (5951753)
1966
49
A giant adenosarcoma of the breast. (20271773)
1947
50
A Study of the Histopathology of the So-Called Adenosarcoma of Swine. (19969781)
1928

Genetic Variations for Adenosarcoma

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Expression for genes affiliated with Adenosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for genes affiliated with Adenosarcoma

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53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Adenosarcoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Adenosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6MME
2estrogen4410.1CALB2
3Ethynodiol Diacetate1110.0ESR1, PGR
4ici 1643844410.0ESR1, PGR
5sodium dodecylsulfate449.7PGR, AR, DES
6norgestimate44 1110.7PGR, AR, ESR1
7nandrolone44 2410.6AR, ESR1, PGR
8anastrozole44 1110.6MKI67, PGR, ESR1
9exemestane49 44 59 1112.6ESR1, PGR, AR
10bisphenol a449.6PGR, ESR1, AR
114-tert-octylphenol449.6ESR1, AR
12lapatinib44 49 1111.6ESR1, AR, PGR
13danazol44 11 2411.6ESR1, PGR, AR
14adriamycin449.6MB, DES, PGR, MME
15levonorgestrel44 59 28 1112.5PGR, AR, ESR1
16mucicarmine449.5DES, CALB2, ACTC1
17progestin449.4AR, DES, ESR1, PGR
18flutamide44 59 1111.3AR, ESR1, PGR
19paclitaxel44 49 1111.3CALB2, PGR, ESR1
20vinclozolin449.3AR, ESR1
21steroidal449.2ESR1, PGR, AR
22dihydrotestosterone44 28 11 2412.2AR, ESR1, DES, PGR
23geldanamycin44 49 59 1112.2KIT, AR, PGR, ESR1
24fulvestrant44 49 28 1112.1PGR, ESR1, MKI67, AR
25letrozole44 49 59 1112.1ESR1, PGR, AR, MKI67
2617beta-hydroxysteroid449.1MKI67, ESR1, AR, PGR
27progestins449.1ESR1, MKI67, AR, PGR
28imatinib44 49 1111.1WT1, KIT, ACTC1, DES
29formaldehyde44 2410.1MKI67, DES, KIT, ACTC1
30b 723449.1DES, WT1, ACTC1, CALB2
31docetaxel44 49 59 1112.1PGR, KIT, ESR1, AR
32mifepristone44 59 28 1112.1AR, MKI67, PGR, ESR1
33ribonucleic acid449.1PGR, KIT, WT1, MME, ACTC1
34actinomycin d448.9ESR1, KIT, MME, DES, AR
35hyaluronic acid44 249.9CALB2, MB, WT1, DES
36gnrh448.8PGR, MKI67, AR, MME, ESR1
37estradiol44 11 2410.7PGR, AR, ESR1, DES, MKI67
38glutamine448.6MB, WT1, AR, PGR, KIT
39hematoxylin448.6CALB2, ACTC1, KIT, DES, MKI67
40lactate448.5MB, DES, MKI67, MME, KIT
41arginine448.4MB, WT1, AR, DES, MKI67, MME
42thymidine44 249.1KIT, MME, MKI67, DES, WT1, CALB2
43nitric oxide44 11 2410.0KIT, MKI67, MME, CALB2, WT1, DES
44retinoic acid44 248.4WT1, PGR, MME, AR, DES, MKI67
45steroid447.4ESR1, ACTC1, MKI67, MME, DES, AR
46doxorubicin44 49 119.4ESR1, MKI67, PGR, DES, MB, AR
47vegf447.1ACTC1, PGR, DES, AR, MME, KIT
48progesterone44 59 28 11 2410.6ESR1, CALB2, WT1, AR, DES, ACTC1
49paraffin446.3AR, MME, ACTC1, ESR1, KIT, PGR
50testosterone44 59 11 249.3CALB2, MB, WT1, AR, DES, MKI67

GO Terms for genes affiliated with Adenosarcoma

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16Gene Ontology
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Cellular components related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.2ESR1, PGR, AR, CTDSP2, WT1

Biological processes related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:0607489.6PGR, AR
2positive regulation of phospholipase C activityGO:0108639.5KIT, ESR1
3mammary gland alveolus developmentGO:0607499.3ESR1, AR
4transcription initiation from RNA polymerase II promoterGO:0063679.2ESR1, PGR, AR
5male gonad developmentGO:0085848.8ESR1, KIT, AR, WT1

Molecular functions related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.8ESR1, PGR
2protein bindingGO:0055156.4ESR1, WT1, CTDSP2, AR, DES, MKI67

Products for genes affiliated with Adenosarcoma

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Sources for Adenosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet