MCID: ADN020
MIFTS: 49

Adenosarcoma malady

Summaries for Adenosarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

MalaCards: Adenosarcoma, also known as mullerian adenosarcoma, is related to endometriosis and peritonitis. An important gene associated with Adenosarcoma is DES (desmin), and among its related pathways are PIP3 activates AKT signaling and Nuclear Receptor transcription pathway. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and ovary, and related mouse phenotypes are muscle and homeostasis/metabolism.

Wikipedia:63 Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign... more...

Aliases & Classifications for Adenosarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

adenosarcoma 8 10 44 60
mullerian adenosarcoma 8


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Disease Ontology8 DOID:1974
NCIt39 C9474
SNOMED-CT56 31470003, 189804002
MeSH34 D018195

Related Diseases for Adenosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Adenosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1endometriosis30.7CALB2, PGR, ACTC1, ESR1
2peritonitis30.3MB
3breast cancer30.2AR, PGR, ESR1
4adenofibroma30.2CALB2
5adenocarcinoma30.1MKI67, CALB2, PGR, AR, ESR1, MME
6sarcoma30.1MKI67, DES, WT1, MB, CALB2, KIT
7uterine carcinosarcoma30.0KIT
8angiosarcoma30.0CALB2, ACTC1
9rhabdomyosarcoma30.0ACTC1, DES, WT1, MB, CALB2
10cystadenoma29.8MME
11adenoma29.8CALB2, ACTC1, MKI67
12endometrial carcinoma29.8PGR, MME, AR, ESR1
13ovarian cancer29.8WT1, PGR, ESR1, CALB2
14gastrointestinal stromal tumor29.8ACTC1, KIT, MKI67, DES
15cervical adenosarcoma10.4
16adenosarcoma of the uterus10.3
17uterine corpus adenosarcoma10.3
18vaginal adenosarcoma10.3
19cervicitis10.2
20fallopian tube adenosarcoma10.2
21ovarian mesodermal adenosarcoma10.2
22vaginitis10.2
23adenosarcoma of the cervix uteri10.2
24adenosarcoma of the corpus uteri10.0
25hemangioma10.0ACTC1
26chordoma10.0DES
27papilloma10.0ACTC1
28infantile myofibromatosis10.0DES
29glomerulonephritis10.0MME
30fasciitis10.0ACTC1
31congestive heart failure10.0MME
32lipoma10.0DES
33hypertrophic cardiomyopathy10.0ACTC1
34deficiency anemia10.0MME
35osteosarcoma10.0ESR1
36hypertension10.0MME
37leydig cell tumor10.0CALB2
38pheochromocytoma10.0CALB2
39thymoma10.0CALB2
40cerebral meningioma10.0PGR
41colon cancer10.0CALB2
42nephroblastoma10.0WT1
43malignant fibroxanthoma10.0MB
44arthritis10.0MB
45azoospermia10.0AR
46prostatic hypertrophy10.0AR
47germ cell cancer10.0AR
48myoepithelioma10.0ACTC1
49eosinophilia10.0MB
50epithelioid leiomyosarcoma10.0ACTC1, DES

Graphical network of the top 20 diseases related to Adenosarcoma:



Diseases related to adenosarcoma

Clinical Features for Adenosarcoma

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Drugs & Therapeutics for Adenosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Adenosarcoma

Drug clinical trials:

Search ClinicalTrials for Adenosarcoma

Search NIH Clinical Center for Adenosarcoma

Search CenterWatch for Adenosarcoma

Genetic Tests for Adenosarcoma

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Anatomical Context for Adenosarcoma

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32MalaCards
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MalaCards organs/tissues related to Adenosarcoma:

32
Uterus, Cervix, Ovary, Breast, Liver, Kidney, Lung, Bone, Testis, Smooth muscle

Animal Models for Adenosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.3ESR1, ACTC1, WT1, MB
2MP:00053768.5MB, AR, DES, PGR, ACTC1, ESR1
3MP:00053708.3WT1, AR, MME, KIT, ESR1
4MP:00053808.1MB, WT1, AR, PGR, KIT, ESR1
5MP:00053847.8WT1, AR, PGR, KIT, ACTC1, ESR1
6MP:00053857.6MB, WT1, AR, DES, PGR, KIT
7MP:00028737.6CALB2, WT1, AR, PGR, KIT, ACTC1
8MP:00107687.2MB, WT1, AR, DES, PGR, KIT

Publications for Adenosarcoma

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50PubMed
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Articles related to Adenosarcoma:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
Serum CA125 changes in one case with malignant transformation from benign endometriosis to MA1llerian adenosarcoma. (24033977)
2013
2
Low-grade MA1llerian adenosarcoma with prominent decidualization, involving bilateral ovaries against a background of endometriosis: a diagnostic and treatment challenge. (23793320)
2013
3
Clinical benefit of trabectedin in uterine adenosarcoma. (23456619)
2013
4
Therapeutic effect of dienogest on adenosarcoma arising from endometriosis: a case report. (24324925)
2013
5
MA1llerian adenosarcoma: a frequently misinterpreted diagnosis. (24034536)
2013
6
Uterine adenosarcoma detected by conventional papanicolaou smear: A case report with emphasis on integrating the immunocytochemical staining. (21433006)
2012
7
MA1llerian adenosarcoma of the uterus with heterologous elements: two case reports and literature review. (22382369)
2012
8
Uterine adenosarcoma in a patient with history of breast cancer and long-term tamoxifen consumption. (23087268)
2012
9
MR imaging of uterine adenosarcoma: case report and literature review. (22214910)
2011
10
Activity of pegylated liposomal doxorubicin for extragenital mullerian adenosarcoma with sarcomatous overgrowth: a case report and a review of the literature. (22053671)
2011
11
Uterine mA1llerian adenosarcoma with sarcomatous overgrowth and lung metastasis in a 25-year-old woman. (21446335)
2011
12
Uterine adenosarcoma with bowel metastasis. (21791483)
2011
13
Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients: a case report. (21278890)
2010
14
Coexistence of a clear cell adenocarcinoma and an adenosarcoma with a heterologous rhabdomyosarcoma in an endometriotic cyst of the ovary: a case study. (19483627)
2009
15
Ovarian adenosarcoma with extensive deciduoid morphology arising in endometriosis: a case report. (18580317)
2008
16
Robotically assisted total laparoscopic radical trachelectomy for fertility sparing in stage IB1 adenosarcoma of the cervix. (18803518)
2008
17
MA1llerian adenosarcoma of the ovary: case report and review of the literature. (17805167)
2007
18
Adenosarcoma of an endometrial polyp in a 27-year-old nulligravida: a case report. (17506376)
2007
19
Mullerian adenosarcoma of uterine cervix: report of three cases and review of literature. (17292949)
2007
20
Adenosarcoma of the uterine cervix: positive and differential diagnosis. (17502957)
2007
21
Extrauterine mA1llerian adenosarcoma associated with endometriosis and rectal villotubular adenoma: report of a case and review of the literature. (15823126)
2005
22
Adenosarcoma of the ovary. A case report. (15285316)
2004
23
A case of ovarian adenosarcoma with a heterologous rhabdomyosarcoma component: a brief case report. (15474256)
2004
24
MA1llerian adenosarcoma of vagina arising in persistent endometriosis: report of a case and review of the literature. (12893226)
2003
25
Extragenital mullerian adenosarcoma with sarcomatous overgrowth arising in an endometriotic cyst in the pouch of Douglas. (12801272)
2003
26
Laparoscopic management of 15 patients with infiltrating endometriosis of the bladder and a case of primary intravesical endometrioid adenosarcoma. (12372471)
2002
27
Primary peritoneal mullerian adenosarcoma with sarcomatous overgrowth associated with endometriosis: a case report. (11781526)
2002
28
Uterine adenosarcoma with sarcomatous overgrowth: a case report with cytology of overgrown poorly differentiated sarcoma and immunohistochemical identification of epithelial microinvasion. (12366670)
2002
29
Primary peritoneal mesodermal adenosarcoma: report of a case and review of the literature. (11371146)
2001
30
Uterine adenosarcoma with sarcomatous overgrowth versus uterine carcinosarcoma: comparison of treatment and survival. (11585418)
2001
31
MA1llerian adenosarcoma of the uterus: report of a case with imprint cytology. (11480728)
2001
32
Uterine adenosarcoma with rhabdomyosarcomatous overgrowth. Brief communication. (11055503)
2000
33
Images in clinical medicine. Mullerian adenosarcoma and early pregnancy. (11036123)
2000
34
Vaginal adenosarcoma arising from endometriosis. (10620454)
2000
35
Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-beta1. (8608973)
1996
36
Two unusual presentations of mA1llerian adenosarcoma: case reports, literature review, and treatment considerations. (8522267)
1995
37
MA1llerian adenosarcoma of the cervix: differential diagnosis, histogenesis and review of the literature. (8581155)
1995
38
Adenosarcoma of the uterine cervix: a clinicopathological study of 12 cases. (8600073)
1995
39
Primary extrauterine mA1llerian adenosarcoma of the peritoneum. (7705694)
1995
40
Dedifferentiated extrauterine adenosarcoma responsive to chemotherapy. (8390963)
1993
41
Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. (2156771)
1990
42
Mullerian adenosarcoma of the cervix with heterologous elements: diagnostic and therapeutic approach. (2537782)
1989
43
Stage I uterine adenosarcoma: a report of six cases. (2830437)
1988
44
Infected mA1llerian adenosarcoma of the endometrium. (3031376)
1987
45
Intramural mA1llerian adenosarcoma of the uterus with adenomyosis. (6089698)
1984
46
MA1llerian adenosarcoma of the endometrium: review of the literature and report of two cases. (6313536)
1983
47
Adenosarcoma of the uterus: ultrastructural observations. (217264)
1979
48
MA1llerian adenosarcoma of the uterus. Clinicopathologic report of five cases. (532851)
1979
49
MA1llerian adenosarcoma of the uterine cervix. (205133)
1978
50
Extrauterine mesodermal (mA1llerian) adenosarcoma: a clinicopathologic analysis of five cases. (205129)
1978

Genetic Variations for Adenosarcoma

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Expression for genes affiliated with Adenosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenosarcoma

Search GEO for disease gene expression data for Adenosarcoma.

Pathways for genes affiliated with Adenosarcoma

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53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Adenosarcoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Adenosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6MME
2estrogen4410.1CALB2
3ici 1643844410.0PGR, ESR1
4Ethynodiol Diacetate1110.0ESR1, PGR
5Allylestrenol119.8ESR1, PGR
6sodium dodecylsulfate449.7AR, DES, PGR
7norgestimate44 1110.7ESR1, AR, PGR
8nandrolone44 2410.6PGR, AR, ESR1
9anastrozole44 1110.6ESR1, PGR, MKI67
10exemestane49 44 59 1112.6ESR1, PGR, AR
11bisphenol a449.6ESR1, AR, PGR
12lapatinib44 49 1111.6ESR1, PGR, AR
13danazol44 11 2411.6AR, ESR1, PGR
14adriamycin449.6MME, DES, MB, PGR
15levonorgestrel44 59 28 1112.5ESR1, PGR, AR
16mucicarmine449.5ACTC1, DES, CALB2
17Etonogestrel119.5ESR1, PGR
18progestin449.4DES, ESR1, PGR, AR
19flutamide44 59 1111.3PGR, ESR1, AR
20paclitaxel44 49 1111.3PGR, CALB2, ESR1
21steroidal449.2AR, ESR1, PGR
22dihydrotestosterone44 28 11 2412.2PGR, DES, AR, ESR1
23geldanamycin44 49 59 1112.2ESR1, KIT, PGR, AR
24fulvestrant44 49 28 1112.1ESR1, AR, PGR, MKI67
25letrozole44 49 59 1112.1AR, ESR1, PGR, MKI67
2617beta-hydroxysteroid449.1MKI67, AR, ESR1, PGR
27progestins449.1ESR1, AR, MKI67, PGR
28imatinib44 49 1111.1KIT, ACTC1, WT1, DES
29formaldehyde44 2410.1KIT, MKI67, ACTC1, DES
30b 723449.1CALB2, DES, ACTC1, WT1
31docetaxel44 49 59 1112.1AR, PGR, KIT, ESR1
32mifepristone44 59 28 1112.1ESR1, PGR, MKI67, AR
33ribonucleic acid449.1WT1, MME, PGR, ACTC1, KIT
34actinomycin d448.9KIT, ESR1, MME, DES, AR
35hyaluronic acid44 249.9MB, DES, CALB2, WT1
36gnrh448.8PGR, MKI67, AR, MME, ESR1
37estradiol44 11 2410.7PGR, AR, DES, MKI67, ESR1
38glutamine448.6MB, WT1, KIT, AR, PGR
39hematoxylin448.6KIT, ACTC1, MKI67, DES, CALB2
40lactate448.5MKI67, MME, KIT, DES, MB
41arginine448.4MB, MKI67, AR, WT1, DES, MME
42thymidine44 249.1KIT, MME, MKI67, CALB2, WT1, DES
43nitric oxide44 11 2410.0CALB2, WT1, DES, MKI67, KIT, MME
44retinoic acid44 248.4MME, DES, ESR1, ACTC1, KIT, WT1
45steroid447.4ESR1, ACTC1, MKI67, AR, WT1, CALB2
46doxorubicin44 49 119.4MME, MKI67, AR, WT1, PGR, KIT
47vegf447.1MB, DES, MKI67, MME, KIT, ACTC1
48progesterone44 59 28 11 2410.6PGR, MKI67, ACTC1, ESR1, AR, WT1
49paraffin446.3CALB2, ACTC1, ESR1, MB, KIT, MME
50testosterone44 59 11 249.3CALB2, MB, WT1, AR, DES, MKI67

GO Terms for genes affiliated with Adenosarcoma

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16Gene Ontology
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Cellular components related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.2ESR1, PGR, AR, CTDSP2, WT1

Biological processes related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:0607489.6AR, PGR
2positive regulation of phospholipase C activityGO:0108639.5ESR1, KIT
3mammary gland alveolus developmentGO:0607499.3ESR1, AR
4transcription initiation from RNA polymerase II promoterGO:0063679.2AR, PGR, ESR1
5male gonad developmentGO:0085848.8WT1, ESR1, KIT, AR

Molecular functions related to Adenosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:0054969.8PGR, ESR1
2protein bindingGO:0055156.4WT1, CTDSP2, AR, DES, MKI67, PGR

Products for genes affiliated with Adenosarcoma

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Sources for Adenosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet