MCID: ADN009
MIFTS: 56

Adenosquamous Carcinoma malady

Cancer diseases category

Summaries for Adenosquamous Carcinoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat... more...

MalaCards: Adenosquamous Carcinoma, also known as mixed adenocarcinoma and squamous carcinoma, is related to adenocarcinoma and cervical adenosquamous carcinoma. An important gene associated with Adenosquamous Carcinoma is EPCAM (epithelial cell adhesion molecule), and among its related pathways are Cardiac Progenitor Differentiation and Angiogenesis. The compounds exotoxin-a and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and cervix, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Disease Ontology:9 A squamous cell carcinoma that contains squamous cells and gland-like cells.

Aliases & Classifications for Adenosquamous Carcinoma

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9Disease Ontology, 11DISEASES, 63UMLS, 46Novoseek, 36MeSH, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenosquamous carcinoma 9 11 63
mixed adenocarcinoma and squamous carcinoma 9
adenosquamous cell carcinoma 9
carcinoma adenosquamous 46


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Disease Ontology9 DOID:4830
MeSH36 D018196
SNOMED-CT59 59367005, 403902008
NCIt41 C3727

Related Diseases for Adenosquamous Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Adenosquamous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2PTHLH, KDR, EPCAM, EGFR
2cervical adenosquamous carcinoma31.1HCK
3endometriosis30.3TFRC, KDR, PDGFRA
4lung cancer30.2PTHLH, EPCAM, PDGFRA, EGFR
5gastrointestinal stromal tumor30.1KDR, PDGFRA
6large cell carcinoma30.1PTHLH, EGFR
7hepatocellular carcinoma30.0PDGFRA, EPCAM, KDR
8breast cancer29.9EGFR, EPCAM, KDR, PTHLH
9pancreatitis10.7
10cervicitis10.7
11prostatitis10.6
12gastric adenosquamous carcinoma10.5
13hypercalcemia10.5
14esophageal adenosquamous carcinoma10.4
15thymus adenosquamous carcinoma10.4
16endometrial adenosquamous carcinoma10.4
17cervical adenocarcinoma10.4
18thyroiditis10.4
19barrett's esophagus10.3
20glassy cell variant cervical adenosquamous carcinoma10.3
21ampulla of vater adenosquamous carcinoma10.3
22bartholin's gland adenosquamous carcinoma10.3
23adenosquamous cell lung carcinoma10.3
24adenoma10.3
25cervical cancer10.3
26cystic teratoma10.3
27esophagitis10.3
28teratoma10.3
29duodenitis10.2
30mucoepidermoid carcinoma10.2
31adenoiditis10.2
32adenosquamous colon carcinoma10.2
33adenosquamous breast carcinoma10.2
34hepatitis10.2
35laryngitis10.2
36gliosarcoma10.1TFRC
37neuroendocrine carcinoma10.1
38cystadenoma10.1
39sebaceous adenoma10.1
40good syndrome10.1
41pharyngitis10.1
42villous adenoma10.1
43large cell neuroendocrine carcinoma10.1
44necrotizing sialometaplasia10.1
45adenoid squamous cell carcinoma10.1
46acquired immunodeficiency syndrome10.1
47syringocystadenoma papilliferum10.1
48situs inversus10.1
49choledochal cyst10.1
50balanitis xerotica obliterans10.1

Graphical network of the top 20 diseases related to Adenosquamous Carcinoma:



Diseases related to adenosquamous carcinoma

Symptoms for Adenosquamous Carcinoma

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Drugs & Therapeutics for Adenosquamous Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Adenosquamous Carcinoma

Drug clinical trials:

Search ClinicalTrials for Adenosquamous Carcinoma

Search NIH Clinical Center for Adenosquamous Carcinoma

Search CenterWatch for Adenosquamous Carcinoma

Genetic Tests for Adenosquamous Carcinoma

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Anatomical Context for Adenosquamous Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Adenosquamous Carcinoma:

34
Pancreas, Lung, Cervix, Colon, Liver, Breast, Prostate, Ovary, Skin, Thyroid, Testes, Tongue, Small intestine, Lymph node, Uterus, Testis, Spleen, T cells, Bone

Animal Models for Adenosquamous Carcinoma or affiliated genes

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38MGI
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Publications for Adenosquamous Carcinoma

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53PubMed
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Articles related to Adenosquamous Carcinoma:

(show top 50)    (show all 406)
idTitleAuthorsYear
1
Adenosquamous Carcinoma of the Lung: CT, FDG PET, and Clinicopathologic Findings. (23751831)
2014
2
Differentiation and histogenesis of syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: evidence for a common origin. (24382117)
2014
3
MUC1 and bcl-2 expression in preinvasive lesions and adenosquamous carcinoma of the lung. (23550464)
2013
4
Adenosquamous carcinoma of the pancreas: multidetector-row computed tomographic manifestations and tumor characteristics. (23493198)
2013
5
Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro. (23962337)
2013
6
Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinoma. (23769878)
2013
7
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung. (22996376)
2013
8
Prevalence, distribution, and viral burden of all 15 high-risk human papillomavirus types in adenosquamous carcinoma of the uterine cervix: a multiplex real-time polymerase chain reaction-based study. (24355194)
2013
9
Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma. (22497449)
2012
10
Oral adenosquamous carcinoma: evidence that it arises from the surface mucosal epithelium. (22690906)
2012
11
Cutaneous metastases of cervical adenosquamous carcinoma. (20633787)
2010
12
Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity. (20697320)
2010
13
Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. (21034475)
2010
14
Adenosquamous carcinoma of breast in a 19 years old woman: a case report. (20507552)
2010
15
Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients. (19801164)
2010
16
Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1. (19152726)
2009
17
Adenosquamous carcinoma of the skin: a case series. (19841403)
2009
18
Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma. (18764955)
2008
19
Adenosquamous carcinoma of the nasal cavity. (19006059)
2008
20
Adenosquamous carcinoma of the pancreas: a single-institution experience comparing resection and palliative care. (18722942)
2008
21
Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature. (16515628)
2006
22
Primary adenosquamous carcinoma of the jejunum. (16143036)
2005
23
Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in the treatment of locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri. (16398217)
2005
24
Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases. (15186272)
2004
25
Adenosquamous carcinoma of the liver: clinicopathologic study of 10 surgically treated cases. (12616431)
2003
26
Primary adenosquamous carcinoma of the liver: case report. (12658415)
2002
27
Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible. (12115390)
2002
28
Adenosquamous carcinoma of the pancreas: successful treatment with extended radical surgery, intraoperative radiation therapy, and locoregional chemotherapy. (11558633)
2001
29
Advanced adenosquamous carcinoma of the gallbladder with bilio-biliary fistula: an uncommon case treated by hepatopancreatoduodenectomy. (10430314)
1999
30
Adenosquamous carcinoma of the pancreas. (10367867)
1999
31
Low-grade adenosquamous carcinoma of the breast: a case report with cytologic findings and review of the literature. (9103219)
1997
32
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions. (9439892)
1997
33
A primary adenosquamous carcinoma of the liver with an elevated level of serum squamous cell carcinoma related antigen. (8799411)
1996
34
Clear cell adenosquamous carcinoma of the cervix. An aggressive tumor associated with human papillomavirus-18. (8635063)
1995
35
Primary adenosquamous carcinoma of the colon. (8823993)
1995
36
Adenosquamous carcinoma of the thyroid: a case report and review of the literature. (7673806)
1995
37
The pathology of low-grade adenosquamous carcinoma of the breast. An immunohistochemical study. (7936747)
1994
38
Polypoid adenosquamous carcinoma of the esophagus with prominent spindle cells. Report of a case with immunohistochemical and ultrastructural studies. (7683870)
1993
39
A matched study of surgically treated stage IB adenosquamous carcinoma and adenocarcinoma of the uterine cervix. (11578353)
1993
40
Liver adenosquamous carcinoma invading the esophagogastric junction - a case-report and a review of the literature. (21584617)
1992
41
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991
42
A phase II clinical trial of diaziquone (AZQ) in the treatment of patients with recurrent adenocarcinoma and adenosquamous carcinoma of the cervix. A Gynecologic Oncology Group study. (2599803)
1989
43
Human papillomavirus DNA in adenosquamous carcinoma and squamous cell carcinoma of the vulva. (2837709)
1988
44
Adenosquamous carcinoma of the stomach. Histogenetic and ultrastructural studies. (3556988)
1987
45
A biologically active parathyroid hormone-like substance secreted by an adenosquamous carcinoma of the transverse colon. (3679201)
1987
46
Adenosquamous carcinoma of the prostate. (3555133)
1987
47
Evaluation of squamous epithelium in adenoacanthoma and adenosquamous carcinoma of the endometrium: immunoperoxidase analysis of involucrin and keratin localization. (6203856)
1984
48
Hyperamylasemia due to poorly differentiated adenosquamous carcinoma of the ovary. (6162432)
1981
49
Test and teach. Number twenty-eight. Diagnosis: adenosquamous carcinoma of the stomach. (7220093)
1981
50
Adenosquamous carcinoma of the cecum arising in endometriosis. (7372199)
1980

Variations for Adenosquamous Carcinoma

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Expression for genes affiliated with Adenosquamous Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenosquamous Carcinoma

Search GEO for disease gene expression data for Adenosquamous Carcinoma.

Pathways for genes affiliated with Adenosquamous Carcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 54QIAGEN, 31KEGG, 62Tocris Bioscience, 61Thomson Reuters, 52PharmGKB, 55R&D Systems, 56Reactome
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Pathways related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PDGFRA, KDR
29.4KDR, PDGFRA
3
Show member pathways
Angiogenesis39
9.4PDGFRA, KDR
49.2EGFR, HCK
59.2HCK, EGFR
69.2PDGFRA, EGFR
79.2EGFR, PDGFRA
89.1EGFR, TFRC
9
Show member pathways
9.0EGFR, KDR
109.0EGFR, KDR
11
Show member pathways
8.6HCK, KDR, EGFR
12
Show member pathways
8.6EGFR, KDR, HCK
13
Show member pathways
8.6EGFR, PDGFRA, KDR
14
Show member pathways
8.6EGFR, PDGFRA, KDR
15
Show member pathways
8.6EGFR, PDGFRA, KDR
16
Show member pathways
8.6EGFR, PDGFRA, KDR
17
Show member pathways
8.6EGFR, PDGFRA, KDR
18
Show member pathways
8.6EGFR, PDGFRA, KDR
19
Show member pathways
8.6EGFR, PDGFRA, KDR
20
Show member pathways
8.6KDR, PDGFRA, EGFR
21
Show member pathways
8.6KDR, PDGFRA, EGFR
22
Show member pathways
8.6KDR, PDGFRA, EGFR
23
Show member pathways
8.6KDR, PDGFRA, EGFR
24
Show member pathways
8.6KDR, PDGFRA, EGFR
25
Show member pathways
8.6KDR, PDGFRA, EGFR
268.6KDR, PDGFRA, EGFR
278.6KDR, PDGFRA, EGFR
28
Show member pathways
8.6KDR, PDGFRA, EGFR
298.2EGFR, PDGFRA, KDR, HCK
30
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
8.2HCK, KDR, PDGFRA, EGFR
318.1TFRC, KDR, PDGFRA, EGFR
32
Show member pathways
8.1EGFR, PDGFRA, KDR, PTHLH

Compounds for genes affiliated with Adenosquamous Carcinoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 3BitterDB
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Compounds related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1exotoxin-a469.9EPCAM, TFRC
2pkc 412469.8PDGFRA, KDR
3pazopanib52 1210.7PDGFRA, KDR
4ponatinib52 1210.7PDGFRA, KDR
5ptk787469.4KDR, EGFR
6pki-166469.4KDR, EGFR
7pd153035469.4EGFR, PTHLH
8quinazoline469.4EGFR, KDR
9zd6474469.4EGFR, KDR
10vandetanib52 1210.4EGFR, KDR
11su5416469.4EGFR, KDR
12dasatinib46 52 1211.4EGFR, HCK
13calcitriol46 62 25 1212.3PDGFRA, PTHLH, TFRC
14taxane469.3KDR, EGFR
15tgf beta1469.3PTHLH, KDR, PDGFRA
16folate469.2TFRC, KDR, PDGFRA
17marimastat46 62 1211.2EGFR, KDR
18ag-1296469.1PTHLH, PDGFRA, EGFR
19polysaccharide469.1TFRC, HCK, KDR
20cetuximab46 52 1211.1EGFR, KDR
21herbimycin a46 6210.1EGFR, HCK, TFRC
22trastuzumab46 52 1211.1EGFR, EPCAM, KDR
23indomethacin46 30 62 1212.0KDR, PTHLH, TFRC
24erlotinib46 52 1211.0EGFR, KDR
25sunitinib46 52 1211.0EGFR, PDGFRA, KDR
26regorafenib52 1210.0KDR, PDGFRA, EGFR
27gf 109203x46 6210.0EGFR, PTHLH, TFRC
285fluorouracil469.0KDR, EPCAM, EGFR
29progestin468.9EGFR, KDR, PTHLH
30suramin46 30 1210.9EGFR, KDR, TFRC
31agar468.8PTHLH, KDR, EGFR
32n acetylcysteine468.8TFRC, KDR, EGFR
33tamoxifen46 52 30 1211.7PTHLH, KDR, EGFR
34imatinib46 52 1210.6HCK, KDR, PDGFRA, EGFR
35phosphotyrosine468.6HCK, KDR, PDGFRA, EGFR
36ly294002468.5TFRC, KDR, EGFR
37adp46 30 2510.5EGFR, PDGFRA, KDR, HCK
38rapamycin468.5TFRC, KDR, PDGFRA, EGFR
39Adenosine triphosphate25 129.5HCK, KDR, PDGFRA, EGFR
40thymidine46 259.4PDGFRA, EPCAM, KDR, PTHLH, TFRC
41paclitaxel46 52 1210.4EGFR, KDR, PTHLH, TFRC
42doxorubicin46 52 1210.4EGFR, KDR, TFRC
43cisplatin46 52 62 1211.4EGFR, KDR, PTHLH, TFRC
44genistein46 30 62 3 25 1213.2EGFR, KDR, TFRC
45vegf468.0TFRC, PTHLH, KDR, PDGFRA, EGFR
46estrogen467.9TFRC, PTHLH, KDR, PDGFRA, EGFR
47paraffin467.6EGFR, PDGFRA, EPCAM, KDR, PTHLH, TFRC
48phosphatidylinositol467.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR
49retinoic acid46 258.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR
50tyrosine467.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR

GO Terms for genes affiliated with Adenosquamous Carcinoma

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17Gene Ontology
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Cellular components related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.8PDGFRA, KDR, TFRC
2endosomeGO:0057688.5EGFR, KDR, TFRC
3cell surfaceGO:0099868.5TFRC, EPCAM, EGFR
4plasma membraneGO:0058867.7EGFR, PDGFRA, EPCAM, KDR, TFRC

Biological processes related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1signal transduction involved in regulation of gene expressionGO:0230199.9PDGFRA, EPCAM
2surfactant homeostasisGO:0431299.6PTHLH, KDR
3lung alveolus developmentGO:0482869.5KDR, PTHLH
4positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5PDGFRA, KDR
5regulation of cell shapeGO:0083609.4KDR, HCK
6positive regulation of DNA replicationGO:0457409.4PDGFRA, EGFR
7positive regulation of fibroblast proliferationGO:0481469.3EGFR, PDGFRA
8lung developmentGO:0303249.2EGFR, PDGFRA
9positive regulation of ERK1 and ERK2 cascadeGO:0703748.9EGFR, PDGFRA, KDR
10positive regulation of cell migrationGO:0303358.8EGFR, PDGFRA, KDR
11viral processGO:0160328.7TFRC, HCK, KDR, PDGFRA
12positive regulation of protein phosphorylationGO:0019348.7EGFR, KDR
13negative regulation of apoptotic processGO:0430668.7HCK, KDR, EGFR
14innate immune responseGO:0450878.7HCK, PDGFRA, EGFR
15peptidyl-tyrosine phosphorylationGO:0181088.5HCK, KDR, PDGFRA, EGFR
16protein autophosphorylationGO:0467778.5HCK, KDR, PDGFRA, EGFR
17positive regulation of cell proliferationGO:0082847.6EGFR, PDGFRA, EPCAM, KDR, PTHLH, HCK

Molecular functions related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:0380859.5PDGFRA, KDR
2vascular endothelial growth factor-activated receptor activityGO:0050219.5PDGFRA, KDR
3receptor signaling protein tyrosine kinase activityGO:0047169.0EGFR, KDR
4integrin bindingGO:0051789.0EGFR, KDR
5transmembrane receptor protein tyrosine kinase activityGO:0047148.8EGFR, PDGFRA, KDR
6protein tyrosine kinase activityGO:0047138.7HCK, KDR, EGFR
7ATP bindingGO:0055248.1HCK, KDR, PDGFRA, EGFR
8protein bindingGO:0055157.0TFRC, HCK, KDR, EPCAM, PDGFRA, EGFR

Products for genes affiliated with Adenosquamous Carcinoma

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Sources for Adenosquamous Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet