MCID: ADN009
MIFTS: 57

Adenosquamous Carcinoma malady

Cancer diseases category
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Summaries for Adenosquamous Carcinoma

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Wikipedia:65 Adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat... more...

MalaCards based summary: Adenosquamous Carcinoma, also known as adenosquamous cell carcinoma, is related to cervical adenosquamous carcinoma and adenocarcinoma. An important gene associated with Adenosquamous Carcinoma is EPCAM (epithelial cell adhesion molecule), and among its related pathways are Cardiac Progenitor Differentiation and Angiogenesis. The compounds exotoxin-a and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and cervix, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Disease Ontology:8 A squamous cell carcinoma that contains squamous cells and gland-like cells.

Aliases & Classifications for Adenosquamous Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
See all sources

Adenosquamous Carcinoma, Aliases & Descriptions:

Name: Adenosquamous Carcinoma 8 10 62
Adenosquamous Cell Carcinoma 8 62
 
Mixed Adenocarcinoma and Squamous Carcinoma 8
Carcinoma Adenosquamous 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


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Disease Ontology8 DOID:4830
MeSH34 D018196
SNOMED-CT57 403902008, 59367005
NCIt39 C3727

Related Diseases for Adenosquamous Carcinoma

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Diseases related to Adenosquamous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1cervical adenosquamous carcinoma31.7HCK
2adenocarcinoma30.8PTHLH, KDR, EPCAM, EGFR
3gastrointestinal stromal tumor30.3KDR, PDGFRA
4endometriosis30.3TFRC, KDR, PDGFRA
5large cell carcinoma30.1PTHLH, EGFR
6lung cancer30.0PTHLH, EPCAM, PDGFRA, EGFR
7breast cancer29.4EGFR, EPCAM, KDR, PTHLH
8pancreatitis10.7
9cervicitis10.7
10prostatitis10.7
11gastric adenosquamous carcinoma10.6
12hypercalcemia10.5
13esophageal adenosquamous carcinoma10.4
14thymus adenosquamous carcinoma10.4
15endometrial adenosquamous carcinoma10.4
16cervical cancer10.4
17bartholin's gland adenosquamous carcinoma10.4
18adenosquamous cell lung carcinoma10.4
19glassy cell variant cervical adenosquamous carcinoma10.4
20cervical adenocarcinoma10.4
21thyroiditis10.4
22gliosarcoma10.4TFRC
23adenosquamous colon carcinoma10.3
24ampulla of vater adenosquamous carcinoma10.3
25barrett's esophagus10.3
26adenoma10.3
27cystic teratoma10.3
28esophagitis10.3
29teratoma10.3
30gastric cancer10.2
31hepatitis10.2
32neuroendocrine carcinoma10.2
33adenosquamous gallbladder carcinoma10.2
34adenosquamous breast carcinoma10.2
35adenosquamous pancreas carcinoma10.2
36adenosquamous prostate carcinoma10.2
37mucoepidermoid carcinoma10.2
38adenoiditis10.2
39duodenitis10.2
40breast metaplastic carcinoma10.2
41laryngitis10.2
42kidney cancer10.2EGFR
43merkel cell carcinoma10.2KDR, EPCAM
44diarrhea10.2EGFR
45kidney rhabdoid cancer10.1EPCAM, KDR
46angiosarcoma10.1KDR, PDGFRA
47hepatocellular carcinoma10.1
48kartagener syndrome10.1
49sinusitis10.1
50cystadenoma10.1

Graphical network of the top 20 diseases related to Adenosquamous Carcinoma:



Diseases related to adenosquamous carcinoma

Symptoms for Adenosquamous Carcinoma

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Drugs & Therapeutics for Adenosquamous Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Adenosquamous Carcinoma

Search NIH Clinical Center for Adenosquamous Carcinoma

Genetic Tests for Adenosquamous Carcinoma

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Anatomical Context for Adenosquamous Carcinoma

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MalaCards organs/tissues related to Adenosquamous Carcinoma:

32
Pancreas, Lung, Cervix, Colon, Liver, Breast, Prostate, Skin, Ovary, Thyroid, Tongue, Small intestine, Testes, Lymph node, Bone, Spleen, Uterus, Testis, T cells

Animal Models for Adenosquamous Carcinoma or affiliated genes

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Publications for Adenosquamous Carcinoma

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Articles related to Adenosquamous Carcinoma:

(show top 50)    (show all 426)
idTitleAuthorsYear
1
Differential clinical characteristics, treatment response and prognosis of locally advanced adenocarcinoma/adenosquamous carcinoma and squamous cell carcinoma of cervix treated with definitive radiotherapy. (24666257)
2014
2
Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. (24973941)
2014
3
Low-grade adenosquamous carcinoma of the breast with diverse expression patterns of myoepithelial cell markers on immunohistochemistry: a case study. (25013422)
2014
4
Adenosquamous Carcinoma of the Lung: CT, FDG PET, and Clinicopathologic Findings. (23751831)
2014
5
Adenosquamous carcinoma of vesicovaginal fistula: a rare entity. (24876979)
2014
6
MUC1 and bcl-2 expression in preinvasive lesions and adenosquamous carcinoma of the lung. (23550464)
2013
7
Adenosquamous carcinoma of the pancreas: multidetector-row computed tomographic manifestations and tumor characteristics. (23493198)
2013
8
Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro. (23962337)
2013
9
Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinoma. (23769878)
2013
10
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung. (22996376)
2013
11
Prevalence, distribution, and viral burden of all 15 high-risk human papillomavirus types in adenosquamous carcinoma of the uterine cervix: a multiplex real-time polymerase chain reaction-based study. (24355194)
2013
12
Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma. (22497449)
2012
13
Oral adenosquamous carcinoma: evidence that it arises from the surface mucosal epithelium. (22690906)
2012
14
Cutaneous metastases of cervical adenosquamous carcinoma. (20633787)
2010
15
Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity. (20697320)
2010
16
Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. (21034475)
2010
17
Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1. (19152726)
2009
18
Adenosquamous carcinoma of the skin: a case series. (19841403)
2009
19
Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma. (18764955)
2008
20
Adenosquamous carcinoma of the nasal cavity. (19006059)
2008
21
Adenosquamous carcinoma of the pancreas: a single-institution experience comparing resection and palliative care. (18722942)
2008
22
Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature. (16515628)
2006
23
Primary adenosquamous carcinoma of the jejunum. (16143036)
2005
24
Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. (14627990)
2003
25
Adenosquamous carcinoma of the liver: clinicopathologic study of 10 surgically treated cases. (12616431)
2003
26
Primary adenosquamous carcinoma of the liver: case report. (12658415)
2002
27
Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible. (12115390)
2002
28
Adenosquamous carcinoma of the pancreas: successful treatment with extended radical surgery, intraoperative radiation therapy, and locoregional chemotherapy. (11558633)
2001
29
Advanced adenosquamous carcinoma of the gallbladder with bilio-biliary fistula: an uncommon case treated by hepatopancreatoduodenectomy. (10430314)
1999
30
Adenosquamous carcinoma of the pancreas. (10367867)
1999
31
Low-grade adenosquamous carcinoma of the breast: a case report with cytologic findings and review of the literature. (9103219)
1997
32
Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions. (9439892)
1997
33
A primary adenosquamous carcinoma of the liver with an elevated level of serum squamous cell carcinoma related antigen. (8799411)
1996
34
Clear cell adenosquamous carcinoma of the cervix. An aggressive tumor associated with human papillomavirus-18. (8635063)
1995
35
Primary adenosquamous carcinoma of the colon. (8823993)
1995
36
Adenosquamous carcinoma of the thyroid: a case report and review of the literature. (7673806)
1995
37
The pathology of low-grade adenosquamous carcinoma of the breast. An immunohistochemical study. (7936747)
1994
38
Polypoid adenosquamous carcinoma of the esophagus with prominent spindle cells. Report of a case with immunohistochemical and ultrastructural studies. (7683870)
1993
39
A matched study of surgically treated stage IB adenosquamous carcinoma and adenocarcinoma of the uterine cervix. (11578353)
1993
40
Liver adenosquamous carcinoma invading the esophagogastric junction - a case-report and a review of the literature. (21584617)
1992
41
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991
42
A phase II clinical trial of diaziquone (AZQ) in the treatment of patients with recurrent adenocarcinoma and adenosquamous carcinoma of the cervix. A Gynecologic Oncology Group study. (2599803)
1989
43
Human papillomavirus DNA in adenosquamous carcinoma and squamous cell carcinoma of the vulva. (2837709)
1988
44
Adenosquamous carcinoma of the stomach. Histogenetic and ultrastructural studies. (3556988)
1987
45
A biologically active parathyroid hormone-like substance secreted by an adenosquamous carcinoma of the transverse colon. (3679201)
1987
46
Adenosquamous carcinoma of the prostate. (3555133)
1987
47
Evaluation of squamous epithelium in adenoacanthoma and adenosquamous carcinoma of the endometrium: immunoperoxidase analysis of involucrin and keratin localization. (6203856)
1984
48
Hyperamylasemia due to poorly differentiated adenosquamous carcinoma of the ovary. (6162432)
1981
49
Test and teach. Number twenty-eight. Diagnosis: adenosquamous carcinoma of the stomach. (7220093)
1981
50
Adenosquamous carcinoma of the cecum arising in endometriosis. (7372199)
1980

Variations for Adenosquamous Carcinoma

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Expression for genes affiliated with Adenosquamous Carcinoma

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Expression patterns in normal tissues for genes affiliated with Adenosquamous Carcinoma

Search GEO for disease gene expression data for Adenosquamous Carcinoma.

Pathways for genes affiliated with Adenosquamous Carcinoma

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Pathways related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PDGFRA, KDR
29.4KDR, PDGFRA
3
Show member pathways
Angiogenesis37
9.4PDGFRA, KDR
49.2EGFR, HCK
59.2HCK, EGFR
69.2PDGFRA, EGFR
79.2EGFR, PDGFRA
89.1EGFR, TFRC
9
Show member pathways
9.0EGFR, KDR
109.0EGFR, KDR
11
Show member pathways
8.6HCK, KDR, EGFR
12
Show member pathways
8.6EGFR, KDR, HCK
13
Show member pathways
8.6EGFR, PDGFRA, KDR
14
Show member pathways
8.6EGFR, PDGFRA, KDR
15
Show member pathways
8.6EGFR, PDGFRA, KDR
16
Show member pathways
8.6EGFR, PDGFRA, KDR
17
Show member pathways
8.6EGFR, PDGFRA, KDR
18
Show member pathways
8.6EGFR, PDGFRA, KDR
19
Show member pathways
8.6EGFR, PDGFRA, KDR
20
Show member pathways
8.6KDR, PDGFRA, EGFR
21
Show member pathways
8.6KDR, PDGFRA, EGFR
22
Show member pathways
8.6KDR, PDGFRA, EGFR
23
Show member pathways
8.6KDR, PDGFRA, EGFR
24
Show member pathways
8.6KDR, PDGFRA, EGFR
25
Show member pathways
8.6KDR, PDGFRA, EGFR
268.6KDR, PDGFRA, EGFR
278.6KDR, PDGFRA, EGFR
28
Show member pathways
8.6KDR, PDGFRA, EGFR
298.2EGFR, PDGFRA, KDR, HCK
30
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.2HCK, KDR, PDGFRA, EGFR
318.1TFRC, KDR, PDGFRA, EGFR
32
Show member pathways
8.1EGFR, PDGFRA, KDR, PTHLH

Compounds for genes affiliated with Adenosquamous Carcinoma

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Compounds related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1exotoxin-a449.9EPCAM, TFRC
2pkc 412449.8PDGFRA, KDR
3pazopanib50 1110.7PDGFRA, KDR
4ponatinib50 1110.7PDGFRA, KDR
5ptk787449.4KDR, EGFR
6pki-166449.4KDR, EGFR
7pd153035449.4EGFR, PTHLH
8quinazoline449.4EGFR, KDR
9zd6474449.4EGFR, KDR
10vandetanib50 1110.4EGFR, KDR
11su5416449.4EGFR, KDR
12dasatinib44 50 1111.4EGFR, HCK
13calcitriol44 61 24 1112.3PDGFRA, PTHLH, TFRC
14taxane449.3KDR, EGFR
15tgf beta1449.3PTHLH, KDR, PDGFRA
16folate449.2TFRC, KDR, PDGFRA
17marimastat44 61 1111.2EGFR, KDR
18ag-1296449.1PTHLH, PDGFRA, EGFR
19polysaccharide449.1TFRC, HCK, KDR
20cetuximab44 50 1111.1EGFR, KDR
21herbimycin a44 6110.1EGFR, HCK, TFRC
22trastuzumab44 50 1111.1EGFR, EPCAM, KDR
23indomethacin44 28 61 1112.0KDR, PTHLH, TFRC
24erlotinib44 50 1111.0EGFR, KDR
25sunitinib44 50 1111.0EGFR, PDGFRA, KDR
26regorafenib50 1110.0KDR, PDGFRA, EGFR
27gf 109203x44 6110.0EGFR, PTHLH, TFRC
285fluorouracil449.0KDR, EPCAM, EGFR
29progestin448.9EGFR, KDR, PTHLH
30suramin44 28 1110.9EGFR, KDR, TFRC
31agar448.8PTHLH, KDR, EGFR
32n acetylcysteine448.8TFRC, KDR, EGFR
33tamoxifen44 50 28 1111.7PTHLH, KDR, EGFR
34imatinib44 50 1110.6HCK, KDR, PDGFRA, EGFR
35phosphotyrosine448.6HCK, KDR, PDGFRA, EGFR
36ly294002448.5TFRC, KDR, EGFR
37adp44 28 2410.5EGFR, PDGFRA, KDR, HCK
38rapamycin448.5TFRC, KDR, PDGFRA, EGFR
39Adenosine triphosphate24 119.5HCK, KDR, PDGFRA, EGFR
40thymidine44 249.4PDGFRA, EPCAM, KDR, PTHLH, TFRC
41paclitaxel44 50 1110.4EGFR, KDR, PTHLH, TFRC
42doxorubicin44 50 1110.4EGFR, KDR, TFRC
43cisplatin44 50 61 1111.4EGFR, KDR, PTHLH, TFRC
44genistein44 28 61 2 24 1113.2EGFR, KDR, TFRC
45vegf448.0TFRC, PTHLH, KDR, PDGFRA, EGFR
46estrogen447.9TFRC, PTHLH, KDR, PDGFRA, EGFR
47paraffin447.6EGFR, PDGFRA, EPCAM, KDR, PTHLH, TFRC
48phosphatidylinositol447.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR
49retinoic acid44 248.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR
50tyrosine447.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR

GO Terms for genes affiliated with Adenosquamous Carcinoma

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Cellular components related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.8PDGFRA, KDR, TFRC
2endosomeGO:0057688.5EGFR, KDR, TFRC
3cell surfaceGO:0099868.5TFRC, EPCAM, EGFR
4plasma membraneGO:0058867.7EGFR, PDGFRA, EPCAM, KDR, TFRC

Biological processes related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1signal transduction involved in regulation of gene expressionGO:0230199.9PDGFRA, EPCAM
2surfactant homeostasisGO:0431299.6PTHLH, KDR
3lung alveolus developmentGO:0482869.5KDR, PTHLH
4positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5PDGFRA, KDR
5regulation of cell shapeGO:0083609.4KDR, HCK
6positive regulation of DNA replicationGO:0457409.4PDGFRA, EGFR
7positive regulation of fibroblast proliferationGO:0481469.3EGFR, PDGFRA
8lung developmentGO:0303249.2EGFR, PDGFRA
9positive regulation of ERK1 and ERK2 cascadeGO:0703748.9EGFR, PDGFRA, KDR
10positive regulation of cell migrationGO:0303358.8EGFR, PDGFRA, KDR
11viral processGO:0160328.7TFRC, HCK, KDR, PDGFRA
12positive regulation of protein phosphorylationGO:0019348.7EGFR, KDR
13negative regulation of apoptotic processGO:0430668.7HCK, KDR, EGFR
14innate immune responseGO:0450878.7HCK, PDGFRA, EGFR
15peptidyl-tyrosine phosphorylationGO:0181088.5HCK, KDR, PDGFRA, EGFR
16protein autophosphorylationGO:0467778.5HCK, KDR, PDGFRA, EGFR
17positive regulation of cell proliferationGO:0082847.6EGFR, PDGFRA, EPCAM, KDR, PTHLH, HCK

Molecular functions related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:0380859.5PDGFRA, KDR
2vascular endothelial growth factor-activated receptor activityGO:0050219.5PDGFRA, KDR
3receptor signaling protein tyrosine kinase activityGO:0047169.0EGFR, KDR
4integrin bindingGO:0051789.0EGFR, KDR
5transmembrane receptor protein tyrosine kinase activityGO:0047148.8EGFR, PDGFRA, KDR
6protein tyrosine kinase activityGO:0047138.7HCK, KDR, EGFR
7ATP bindingGO:0055248.1HCK, KDR, PDGFRA, EGFR
8protein bindingGO:0055157.0TFRC, HCK, KDR, EPCAM, PDGFRA, EGFR

Products for genes affiliated with Adenosquamous Carcinoma

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Sources for Adenosquamous Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet