MCID: ADN009
MIFTS: 55

Adenosquamous Carcinoma malady

Cancer diseases category

Summaries for Adenosquamous Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat... more...

MalaCards: Adenosquamous Carcinoma, also known as mixed adenocarcinoma and squamous carcinoma, is related to adenocarcinoma and cervical adenosquamous carcinoma. An important gene associated with Adenosquamous Carcinoma is EPCAM (epithelial cell adhesion molecule), and among its related pathways are Akt Signaling Pathway and Sorafenib Pharmacodynamics. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and cervix, and related mouse phenotypes are integument and digestive/alimentary.

Disease Ontology:8 A squamous cell carcinoma that contains squamous cells and gland-like cells.

Aliases & Classifications for Adenosquamous Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

adenosquamous carcinoma 8 10 60
mixed adenocarcinoma and squamous carcinoma 8
adenosquamous cell carcinoma 8
carcinoma adenosquamous 44


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Disease Ontology8 DOID:4830
MeSH34 D018196
SNOMED-CT56 59367005, 403902008
NCIt39 C3727

Related Diseases for Adenosquamous Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Adenosquamous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2TFF1, EGFR, IVL, EPCAM, PGK1, KDR
2cervical adenosquamous carcinoma31.0HCK, MAML2, CRTC1
3squamous cell carcinoma30.9EGFR, EPCAM, PTHLH
4cervical adenocarcinoma30.7KRT7, CEACAM7
5mucoepidermoid carcinoma30.7CRTC1, MAML2
6hypercalcemia30.6PTHLH
7endometrial carcinoma30.4TFF1, EGFR, KRT7, CEACAM7
8lung adenocarcinoma30.4CEACAM7, KRT7, KDR, EGFR
9bladder carcinoma30.3TFRC
10lung cancer30.3CSF3, EGFR, KRT7
11cervical cancer30.3CEACAM7, KRT5, IVL, EGFR
12adenoma30.3CEACAM7, KRT13, KRT7, TFRC, TFF1
13hepatitis30.2TFRC
14endometriosis30.2KDR, TFRC, PDGFRA
15large cell carcinoma30.2PTHLH, KRT7, KRT5, IVL, EGFR, CEACAM7
16meningioma30.0TFF1
17hidradenoma30.0MAML2, CRTC1
18necrotizing sialometaplasia30.0CRTC1, MAML2
19papilloma30.0KRT13, KRT5, IVL
20cervical squamous cell carcinoma30.0IVL
21hepatocellular carcinoma30.0PDGFRA, EPCAM, KDR, KRT7, KRT13, CEACAM7
22stomach cancer30.0CEACAM7, KRT7, EGFR, TFF1
23breast cancer30.0TFF1, EGFR, CEACAM7, PTHLH, KRT7, KRT5
24adenosquamous pancreas carcinoma10.8
25adenosquamous colon carcinoma10.7
26cervicitis10.6
27pancreatitis10.6
28adenosquamous breast carcinoma10.6
29adenosquamous gallbladder carcinoma10.6
30gastric adenosquamous carcinoma10.6
31adenosquamous prostate carcinoma10.6
32prostatitis10.6
33in situ carcinoma10.5
34adenosquamous bile duct carcinoma10.5
35adenosquamous cell lung carcinoma10.5
36endometrial adenosquamous carcinoma10.4
37bile duct carcinoma10.4
38esophageal adenosquamous carcinoma10.4
39gallbladder adenocarcinoma10.4
40lung squamous cell carcinoma10.4
41thymus adenosquamous carcinoma10.3
42ampulla of vater adenosquamous carcinoma10.3
43spindle cell carcinoma10.3
44gallbladder squamous cell carcinoma10.3
45adenocarcinoma in situ10.3
46thyroiditis10.3
47neuroendocrine carcinoma10.2
48glassy cell variant cervical adenosquamous carcinoma10.2
49barrett's esophagus10.2
50cystic teratoma10.2

Graphical network of the top 20 diseases related to Adenosquamous Carcinoma:



Diseases related to adenosquamous carcinoma

Clinical Features for Adenosquamous Carcinoma

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Drugs & Therapeutics for Adenosquamous Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Adenosquamous Carcinoma

Drug clinical trials:

Search ClinicalTrials for Adenosquamous Carcinoma

Search NIH Clinical Center for Adenosquamous Carcinoma

Search CenterWatch for Adenosquamous Carcinoma

Genetic Tests for Adenosquamous Carcinoma

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Anatomical Context for Adenosquamous Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Adenosquamous Carcinoma:

32
Pancreas, Lung, Cervix, Colon, Liver, Breast, Prostate, Ovary, Skin, Thyroid, Small intestine, Testes, Tongue, Lymph node, Testis, T cells, Spleen, Bone, Uterus

Animal Models for Adenosquamous Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Adenosquamous Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.2KRT5, KDR, PDGFRA
2MP:00053819.7EPCAM, PTHLH, PDGFRA, TFF1, KRT5, EGFR
3MP:00053859.6TMEM98, TFRC, PTHLH, KDR, EPCAM, HCK
4MP:00053979.5TMEM98, PDGFRA, CSF3, TFRC, CRTC1, EGFR
5MP:00053879.3PDGFRA, TMEM98, PTHLH, KDR, EPCAM, HCK

Publications for Adenosquamous Carcinoma

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50PubMed
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Articles related to Adenosquamous Carcinoma:

(show top 50)    (show all 418)
idTitleAuthorsYear
1
Clinical implications of human papillomavirus genotype in cervical adeno-adenosquamous carcinoma. (23031554)
2013
2
Primary adenosquamous carcinoma of the rectum. (23815994)
2013
3
Nectin-2 and DDX3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. (23330003)
2013
4
Immunohistochemical staining characteristics of low-grade adenosquamous carcinoma of the breast. (22446941)
2012
5
Duodenal metastasis of cervical adenosquamous carcinoma. (22387251)
2012
6
Adenosquamous carcinoma of the liver. (23091815)
2012
7
Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity. (20697320)
2010
8
Primary renal adenosquamous carcinoma. (20981201)
2010
9
Adenosquamous carcinoma of the lacrimal gland. (22802328)
2010
10
Adenosquamous carcinoma of the lateral oropharyngeal wall. (21086267)
2010
11
Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. (19727809)
2009
12
Case of adenosquamous carcinoma of the ascending colon. (18781050)
2008
13
Abnormalities of epidermal growth factor receptor in lung squamous-cell carcinomas, adenosquamous carcinomas, and large-cell carcinomas: tyrosine kinase domain mutations are not rare in tumors with an adenocarcinoma component. (17238183)
2007
14
Cervical adenosquamous carcinoma: tumor implantation in an episiotomy scar. (17666630)
2007
15
Adenosquamous carcinoma of the pancreas. (16172546)
2005
16
Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells. (16126885)
2005
17
Adenosquamous carcinoma of the liver: clinicopathologic study of 10 surgically treated cases. (12616431)
2003
18
Adenosquamous carcinoma of the pancreas: preoperative diagnosis and molecular alterations. (14714256)
2003
19
Primary adenosquamous carcinoma of the liver which produces granulocyte-colony-stimulating factor and parathyroid hormone related protein: association with leukocytosis and hypercalcemia. (11506305)
2001
20
Primary cutaneous adenosquamous carcinoma: a case report and review of the literature. (11737525)
2001
21
Esophageal adenosquamous carcinoma in a cat. (11217072)
2001
22
Adenosquamous carcinoma of the sigmoid colon: report of a case. (11686567)
2001
23
Cervical cancer: the increasing incidence of adenocarcinoma and adenosquamous carcinoma in younger women. (11338801)
2001
24
Comparison of clinical behaviors and responses to radiation between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas of the cervix. (10974754)
2000
25
Upper gastrointestinal bleeding and intestinal perforation due to multiple duodenojejunal metastases from a silent bronchogenic adenosquamous carcinoma. (9826154)
1998
26
Adenosquamous carcinoma of the tongue: report of a case with histochemical, immunohistochemical, and ultrastructural study and review of the literature. (9503453)
1998
27
Intense Ga-67 uptake in adenosquamous carcinoma of the pancreas. (9095322)
1997
28
Adenosquamous carcinoma of the facial bones, skull base, and calvaria: CT and MR manifestations. (9010537)
1997
29
Human papillomavirus DNA in adenocarcinoma and adenosquamous carcinoma of the uterine cervix detected by polymerase chain reaction (PCR). (8188078)
1994
30
Squamous cell carcinoma of the oesophagus with mucin-secreting component (muco-epidermoid carcinoma and adenosquamous carcinoma): a clinicopathologic study and a review of literature. (8131864)
1994
31
Polypoid adenosquamous carcinoma of the esophagus with prominent spindle cells. Report of a case with immunohistochemical and ultrastructural studies. (7683870)
1993
32
A matched study of surgically treated stage IB adenosquamous carcinoma and adenocarcinoma of the uterine cervix. (11578353)
1993
33
Expression of the breast cancer-associated protein pS2 in adenosquamous carcinomas of the gastrointestinal tract. (8323770)
1993
34
Immunohistochemical characteristics of adenosquamous carcinoma of the pancreas. (1372374)
1992
35
Glassy cell features in adenosquamous carcinoma of the uterine cervix. Histologic, ultrastructural, immunohistochemical, and clinical findings. (1716415)
1991
36
Adenosquamous carcinoma of the stomach presenting "giant gastric folds". (2279636)
1990
37
Human papillomavirus DNA in adenosquamous carcinoma and squamous cell carcinoma of the vulva. (2837709)
1988
38
Prevalence of human papillomavirus type 18 DNA in adenocarcinoma and adenosquamous carcinoma of the uterine cervix occurring in Japan. (2848332)
1988
39
Adenosquamous carcinoma and the biology of lung cancer. (3675048)
1987
40
Adenosquamous carcinoma of the lacrimal caruncle: a case report. (3790489)
1986
41
Adenosquamous carcinoma of the skin. An aggressive mucin- and gland-forming squamous carcinoma. (2408585)
1985
42
Adenosquamous carcinoma of the cervix in a woman exposed to diethylstilbestrol in utero. (6823400)
1983
43
Clinicopathologic study of adenosquamous carcinoma of the uterine cervix. (6663147)
1983
44
Adenosquamous carcinoma of the thyroid after radiotherapy for Hodgkin's disease. A case report and review. (6861086)
1983
45
Adenosquamous carcinoma of the renal pelvis. (6846265)
1983
46
Carcinoma of the endometrium. IV. Mixed adenosquamous carcinoma. A clinical-pathological study of 68 cases with long-term follow-up. (7091045)
1982
47
Mixed adenosquamous carcinoma of the cecum: report of a case and review of the literature. (7238241)
1981
48
Adenosquamous carcinoma of the cecum arising in endometriosis. (7372199)
1980
49
Adenosquamous carcinoma of the endometrium. An entity with an inherent poor prognosis? (880545)
1977
50
Adenosquamous carcinoma of the nasal, oral and laryngeal cavities. A clinicopathologic survey of ten cases. (4303164)
1968

Genetic Variations for Adenosquamous Carcinoma

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Expression for genes affiliated with Adenosquamous Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adenosquamous Carcinoma

Search GEO for disease gene expression data for Adenosquamous Carcinoma.

Pathways for genes affiliated with Adenosquamous Carcinoma

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Sources:
52R&D Systems, 49PharmGKB, 59Tocris Bioscience, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDGFRA, EGFR, KDR
2
Hide members
10.2KDR, EGFR, PDGFRA
310.2PGK1, EGFR, TFRC
410.1KRT13, KRT7, KRT5
5
Hide members
10.1PDGFRA, EGFR, HCK, KDR
610.1KDR, HCK, EGFR, PDGFRA
710.1PDGFRA, TFRC, EGFR, KDR
810.0KRT13, KRT7, KRT5, EPCAM

Compounds for genes affiliated with Adenosquamous Carcinoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7IVL, CEACAM7
2dexamethasone44 49 28 1113.7KDR, TFF1
3ptk7874410.6KDR, EGFR
4ag-12964410.6PTHLH, EGFR, PDGFRA
5sunitinib44 49 1112.6PDGFRA, EGFR, KDR
6mesna4410.6CSF3, TFRC
7pki-1664410.6EGFR, KDR
8cycloheximide4410.6CEACAM7, TFRC, TFF1
9taxane4410.6KDR, EGFR, CSF3
10zd64744410.6EGFR, KDR
11indomethacin44 59 28 1113.5TFF1
12quinazoline4410.5EGFR, KDR
13leucovorin44 49 1112.5CSF3, EGFR, KDR
14trastuzumab44 49 1112.5KDR, EPCAM, EGFR
15methylcellulose4410.5IVL, TFRC, CSF3
16paclitaxel44 49 1112.5CSF3, EGFR, PGK1, KDR
17progestin4410.5PTHLH, KDR, EGFR, TFF1
18suramin44 28 1112.5TFRC, EGFR, IVL, KDR
19gf 109203x44 5911.5PTHLH, IVL, EGFR, TFRC
20betacarotene4410.4IVL, EGFR, TFRC
21imatinib44 49 1112.4PDGFRA, CSF3, EGFR, HCK, KDR
22calcitriol44 59 11 2413.4PDGFRA, TFRC, IVL, PTHLH
23hematoxylin4410.4KRT7, IVL, TFF1
24carboplatin44 49 1112.4CSF3, EGFR, KDR
25genistein44 28 59 2 11 2415.4TFF1, TFRC, EGFR, KDR, KRT5
26gefitinib44 49 1112.4EGFR, KDR, CEACAM7
27phosphotyrosine4410.4KDR, HCK, EGFR, PDGFRA
28polysaccharide4410.3TFRC, IVL, HCK, KDR, KRT7
29cisplatin44 49 59 1113.3PTHLH, KDR, EGFR, TFRC, CSF3
30retinoid4410.3TFF1, EGFR, IVL, KRT5, KRT7
31lactate4410.3TFRC, IVL, PGK1, KDR, PTHLH
32lysine4410.3TFF1, IVL, PGK1, KRT5, PTHLH
335fluorouracil4410.3CSF3, EGFR, IVL, EPCAM, KDR, CEACAM7
34phosphatidylinositol4410.2PDGFRA, TFRC, EGFR, IVL, HCK, KDR
35pkc 4124410.2PDGFRA, KDR
36tamoxifen44 49 28 1113.2PTHLH, KDR, EGFR, TFF1
37hydroxyurea44 49 1112.2TFRC, CSF3, PDGFRA
38arginine4410.2TFF1, TFRC, KDR, KRT5, KRT7, PTHLH
3912-o-tetradecanoylphorbol 13-acetate4410.2TFF1, IVL, KRT5, PTHLH
40progesterone44 59 28 11 2414.2TFF1, EGFR, KRT5, KRT7, PTHLH, CEACAM7
41testosterone44 59 11 2413.1TFF1, TFRC, EGFR, PGK1, KRT5, KRT7
42h2o24410.1TFF1, TFRC, HCK, PGK1, KDR
43vitamin d4410.1PTHLH, KRT13, IVL, TFRC
44thymidine44 2411.0PDGFRA, CSF3, TFF1, TFRC, IVL, EPCAM
45gemcitabine44 49 1111.9KDR, EGFR, CSF3
46vegf449.8PDGFRA, CSF3, TFF1, TFRC, EGFR, IVL
47paraffin449.8PDGFRA, TFF1, TFRC, EGFR, IVL, EPCAM
48calcium44 49 11 2412.8PDGFRA, TFF1, CRTC1, IVL, ANXA8L2, ANXA8
49tyrosine449.7PDGFRA, CSF3, TFRC, EGFR, IVL, HCK
50retinoic acid44 2410.4CEACAM7, PDGFRA, CSF3, TFF1, TFRC, EGFR

GO Terms for genes affiliated with Adenosquamous Carcinoma

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16Gene Ontology
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Cellular components related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:04509510.1KRT13, KRT7, KRT5

Biological processes related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.3KDR, CSF3, PDGFRA
2surfactant homeostasisGO:04312910.3KDR, PTHLH
3peptidyl-tyrosine phosphorylationGO:01810810.3KDR, HCK, PDGFRA
4protein autophosphorylationGO:04677710.3PDGFRA, EGFR, HCK, KDR
5positive regulation of ERK1 and ERK2 cascadeGO:07037410.2KDR, EGFR, PDGFRA
6epidermis developmentGO:00854410.1PTHLH, KRT13, KRT5
7modulation by virus of host morphology or physiologyGO:01904810.0PDGFRA, TFRC, CRTC1, HCK, KDR, KRT7
8positive regulation of cell proliferationGO:00828410.0PTHLH, PDGFRA, CSF3, EGFR, HCK, EPCAM
9positive regulation of actin cytoskeleton reorganizationGO:200025110.0HCK, CSF3

Molecular functions related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.3KDR, PDGFRA
2transmembrane receptor protein tyrosine kinase activityGO:00471410.3KDR, EGFR, PDGFRA
3protein tyrosine kinase activityGO:00471310.2KDR, HCK, EGFR
4vascular endothelial growth factor-activated receptor activityGO:00502110.2PDGFRA, KDR
5receptor signaling protein tyrosine kinase activityGO:00471610.0KDR, EGFR

Products for genes affiliated with Adenosquamous Carcinoma

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Sources for Adenosquamous Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet