MCID: ADN009
MIFTS: 53

Adenosquamous Carcinoma malady

Cancer category

Summaries for Adenosquamous Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat... more...

MalaCards: Adenosquamous Carcinoma, also known as mixed adenocarcinoma and squamous carcinoma, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Adenosquamous Carcinoma is EPCAM (epithelial cell adhesion molecule), and among its related pathways are Akt Signaling Pathway and Sorafenib Pharmacodynamics. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and small intestine, and related mouse phenotypes are integument and digestive/alimentary.

Disease Ontology:8 A squamous cell carcinoma that contains squamous cells and gland-like cells.

Aliases & Classifications for Adenosquamous Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

adenosquamous carcinoma 8 10 61
mixed adenocarcinoma and squamous carcinoma 8
adenosquamous cell carcinoma 8
carcinoma adenosquamous 45


External Ids:

Disease Ontology8 DOID:4830
MeSH35 D018196
SNOMED-CT57 59367005, 403902008
NCIt40 C3727

Related Diseases for Adenosquamous Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Adenosquamous Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.3TFF1, EGFR, IVL, EPCAM, PGK1, KDR
2squamous cell carcinoma31.0EGFR, EPCAM, PTHLH
3mucoepidermoid carcinoma30.7CRTC1, MAML2
4hypercalcemia30.7PTHLH
5bladder carcinoma30.4TFRC
6adenoma30.4CEACAM7, KRT13, KRT7, TFRC, TFF1
7large cell carcinoma30.3PTHLH, KRT7, KRT5, IVL, EGFR, CEACAM7
8thymic carcinoma30.0KRT7
9necrotizing sialometaplasia30.0CRTC1, MAML2
10stomach cancer30.0CEACAM7, KRT7, EGFR, TFF1
11adenosquamous pancreas carcinoma10.9
12adenosquamous colon carcinoma10.8
13adenosquamous breast carcinoma10.7
14adenosquamous gallbladder carcinoma10.6
15gastric adenosquamous carcinoma10.6
16adenosquamous prostate carcinoma10.6
17adenosquamous bile duct carcinoma10.5
18adenosquamous cell lung carcinoma10.5
19endometrial adenosquamous carcinoma10.5
20bile duct carcinoma10.5
21esophageal adenosquamous carcinoma10.4
22thymus adenosquamous carcinoma10.3
23spindle cell carcinoma10.3
24gallbladder squamous cell carcinoma10.3
25neuroendocrine carcinoma10.3
26ampulla of vater adenosquamous carcinoma10.3
27glassy cell variant cervical adenosquamous carcinoma10.3
28teratoma10.3
29parathyroid carcinoma10.2
30papillary carcinoma10.2
31bartholin's gland adenosquamous carcinoma10.2
32small cell carcinoma10.2
33vulva squamous cell carcinoma10.2
34squamous cell papilloma10.0
35sebaceous adenoma10.0
36cystadenoma10.0
37bone carcinoma10.0
38lung carcinoma in situ10.0
39balanitis xerotica obliterans10.0
40sweat gland carcinoma10.0
41pleomorphic carcinoma10.0
42pancreatic ductal carcinoma10.0
43lung meningioma10.0
44good syndrome10.0
45adenoid squamous cell carcinoma10.0
46breast osteosarcoma10.0
47gastrointestinal stromal tumor10.0
48schneiderian carcinoma10.0
49acquired immunodeficiency syndrome10.0
50follicular infundibulum tumor10.0

Graphical network of the top 20 diseases related to Adenosquamous Carcinoma:



Diseases related to adenosquamous carcinoma

Clinical Features for Adenosquamous Carcinoma

Drugs & Therapeutics for Adenosquamous Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Adenosquamous Carcinoma

Drug clinical trials:

Search ClinicalTrials for Adenosquamous Carcinoma

Search NIH Clinical Center for Adenosquamous Carcinoma

Search CenterWatch for Adenosquamous Carcinoma

Genetic Tests for Adenosquamous Carcinoma

Anatomical Context for Adenosquamous Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Adenosquamous Carcinoma:

33
Lymph node, Spleen, Small intestine, Colon, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Uterus, Prostate, Testis, Cervix, T cells, B cells, Tongue

Animal Models for Adenosquamous Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Adenosquamous Carcinoma

Sources:
51PubMed
See all sources

Articles related to Adenosquamous Carcinoma:

(show top 50)    (show all 418)
idTitleAuthorsYear
1
Differentiation and histogenesis of syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: evidence for a common origin. (24382117)
2014
2
Adenosquamous carcinoma of the ampulla of Vater - a rare disease at unusual location. (23721111)
2013
3
Isolation of cancer stem like cells from human adenosquamous carcinoma of the lung supports a monoclonal origin from a multipotential tissue stem cell. (24324581)
2013
4
Pancreatic adenosquamous carcinoma presenting as splenic rupture: report of a case. (21626340)
2011
5
Two cases of adenosquamous carcinoma of the cervix with extensive in situ and invasive endometrial extension. (21293279)
2011
6
EGFR and KRAS mutations in Chinese patients with adenosquamous carcinoma of the lung. (21592614)
2011
7
Synchronous tumors: adenosquamous carcinoma of pancreas and GIST of stomach. (20623381)
2011
8
Synchronous primary carcinosarcoma and adenosquamous carcinoma of the esophagus. (21353036)
2011
9
Adenosquamous carcinoma of the lung: a microdissection study of KRAS and EGFR mutational and amplification status in a western patient population. (21502435)
2011
10
Cutaneous metastases of cervical adenosquamous carcinoma. (20633787)
2010
11
Adenosquamous carcinoma of the pancreas: a case report. (20205828)
2010
12
Adenosquamous carcinoma of the extrahepatic bile duct: clinicopathologic and radiologic features. (18204917)
2009
13
Adenosquamous carcinoma of the pancreas, a rare tumor entity: a case report. (20062646)
2009
14
Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma. (18764955)
2008
15
Adenosquamous carcinoma of the nasal cavity. (19006059)
2008
16
Adenosquamous carcinoma versus adenocarcinoma in early-stage cervical cancer patients undergoing radical hysterectomy: an outcomes analysis. (17854872)
2007
17
Adenosquamous carcinoma of oral cavity: a case report. (18338480)
2007
18
Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature. (16515628)
2006
19
Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in the treatment of locally advanced adenocarcinoma or adenosquamous carcinoma of the cervix uteri. (16398217)
2005
20
The biphasic pattern of laryngeal and hypopharyngeal adenosquamous carcinoma is retained in lymph node metastases. (15910609)
2005
21
A clinicopathologic study of primary adenosquamous carcinoma of the liver. (15942444)
2005
22
Thin-layer cytology findings of papillary adenosquamous carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. (12920761)
2003
23
Adenosquamous carcinoma of the pancreas: successful treatment with extended radical surgery, intraoperative radiation therapy, and locoregional chemotherapy. (11558633)
2001
24
Gastric carcinosarcoma, coexistence of adenosquamous carcinoma and rhabdomyosarcoma: a case report. (11737318)
2001
25
Generation of autologous tumor-specific T cell clones from a patient with adenosquamous carcinoma of the lung. (11518743)
2001
26
Synchronous primary adenocarcinoma and adenosquamous carcinoma of the esophagus. (11702129)
2001
27
Primary adenosquamous carcinoma of the rectum. Report of 4 cases and review of the literature. (12790990)
2001
28
Adenosquamous carcinoma of colon. (11817779)
2001
29
Adenosquamous carcinoma of the small intestine. Report of a case and review of the literature. (10420235)
1999
30
p53, p16 and RB expression in adenosquamous and squamous cell carcinomas of the stomach. (10605694)
1999
31
Port-site metastasis following laparoscopic lymphadenectomy for adenosquamous carcinoma of the cervix. (10385565)
1999
32
Human papillomavirus DNA in adenosquamous carcinoma of the lung. (10023336)
1998
33
Primary adenosquamous carcinoma of liver resected by right trisegmentectomy: report of a case and review of the literature. (9430028)
1997
34
Adenosquamous carcinoma of the liver: clinicopathologic characteristics and cytokeratin profile. (9241069)
1997
35
Rectal adenosquamous carcinoma and carcinoma stomach in two family members. (9114577)
1997
36
Pilomatricoma-like endometrioid adenosquamous carcinoma of the ovary with neuroendocrine differentiation. (8626150)
1996
37
Adenosquamous carcinoma of the lung: radiologic appearance. (8037019)
1994
38
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991
39
Adenosquamous carcinoma of the pancreas: a clinicopathologic study. (2062081)
1991
40
Adenosquamous carcinoma of the cervix: prognosis in stage IB. (2342726)
1990
41
Adenosquamous carcinoma of the thyroid gland. (2584863)
1989
42
Vulvar adenosquamous carcinoma arising in a hidradenoma papilliferum, with rapidly fatal outcome: case report. (2557272)
1989
43
Adenosquamous carcinoma of the stomach. Histochemical and ultrastructural study. (3632065)
1987
44
Adenosquamous carcinoma of the liver. (2445198)
1987
45
Human papillomavirus deoxyribonucleic acid in adenocarcinoma and adenosquamous carcinoma of the uterine cervix. (3016624)
1986
46
Adenosquamous carcinoma of the penis associated with balanitis xerotica obliterans. (3801839)
1986
47
Adenosquamous carcinoma of the ileum. Report of a case and review of the literature. (2409665)
1985
48
Cytologic presentation of ovarian adenosquamous carcinoma in ascitic fluid. A case report. (6594883)
1984
49
Adenosquamous carcinoma and carcinoidal differentiation of the colon. Report of a case. (6349782)
1983
50
Adenoepidermoid and adenosquamous carcinoma of the uterus. A clinicopathologic study of 118 cases. (851156)
1977

Genetic Variations for Adenosquamous Carcinoma

Expression for genes affiliated with Adenosquamous Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adenosquamous Carcinoma

Search GEO for disease gene expression data for Adenosquamous Carcinoma.

Pathways for genes affiliated with Adenosquamous Carcinoma

Sources:
53R&D Systems, 50PharmGKB, 60Tocris Bioscience, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Pathways related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2PDGFRA, EGFR, KDR
2
Hide members
10.2KDR, EGFR, PDGFRA
310.2PGK1, EGFR, TFRC
410.1KRT13, KRT7, KRT5
5
Hide members
10.1PDGFRA, EGFR, HCK, KDR
610.1KDR, HCK, EGFR, PDGFRA
710.1PDGFRA, TFRC, EGFR, KDR
810.0KRT13, KRT7, KRT5, EPCAM

Compounds for genes affiliated with Adenosquamous Carcinoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7IVL, CEACAM7
2dexamethasone45 50 29 1113.7KDR, TFF1
3ptk7874510.6KDR, EGFR
4ag-12964510.6PTHLH, EGFR, PDGFRA
5sunitinib45 50 1112.6PDGFRA, EGFR, KDR
6mesna4510.6CSF3, TFRC
7pki-1664510.6EGFR, KDR
8cycloheximide4510.6CEACAM7, TFRC, TFF1
9taxane4510.6KDR, EGFR, CSF3
10zd64744510.6EGFR, KDR
11indomethacin45 60 29 1113.5TFF1
12quinazoline4510.5EGFR, KDR
13leucovorin45 50 1112.5CSF3, EGFR, KDR
14trastuzumab45 50 1112.5KDR, EPCAM, EGFR
15methylcellulose4510.5IVL, TFRC, CSF3
16paclitaxel45 50 1112.5CSF3, EGFR, PGK1, KDR
17progestin4510.5PTHLH, KDR, EGFR, TFF1
18suramin45 29 1112.5TFRC, EGFR, IVL, KDR
19gf 109203x45 6011.5PTHLH, IVL, EGFR, TFRC
20betacarotene4510.4IVL, EGFR, TFRC
21imatinib45 50 1112.4PDGFRA, CSF3, EGFR, HCK, KDR
22calcitriol45 60 11 2413.4PDGFRA, TFRC, IVL, PTHLH
23hematoxylin4510.4KRT7, IVL, TFF1
24carboplatin45 50 1112.4CSF3, EGFR, KDR
25genistein45 29 60 2 11 2415.4TFF1, TFRC, EGFR, KDR, KRT5
26gefitinib45 50 1112.4EGFR, KDR, CEACAM7
27phosphotyrosine4510.4KDR, HCK, EGFR, PDGFRA
28polysaccharide4510.3TFRC, IVL, HCK, KDR, KRT7
29cisplatin45 50 60 1113.3PTHLH, KDR, EGFR, TFRC, CSF3
30retinoid4510.3TFF1, EGFR, IVL, KRT5, KRT7
31lactate4510.3TFRC, IVL, PGK1, KDR, PTHLH
32lysine4510.3TFF1, IVL, PGK1, KRT5, PTHLH
335fluorouracil4510.3CSF3, EGFR, IVL, EPCAM, KDR, CEACAM7
34phosphatidylinositol4510.2PDGFRA, TFRC, EGFR, IVL, HCK, KDR
35pkc 4124510.2PDGFRA, KDR
36tamoxifen45 50 29 1113.2PTHLH, KDR, EGFR, TFF1
37hydroxyurea45 50 1112.2TFRC, CSF3, PDGFRA
38arginine4510.2TFF1, TFRC, KDR, KRT5, KRT7, PTHLH
3912-o-tetradecanoylphorbol 13-acetate4510.2TFF1, IVL, KRT5, PTHLH
40progesterone45 60 29 11 2414.2TFF1, EGFR, KRT5, KRT7, PTHLH, CEACAM7
41testosterone45 60 11 2413.1TFF1, TFRC, EGFR, PGK1, KRT5, KRT7
42h2o24510.1TFF1, TFRC, HCK, PGK1, KDR
43vitamin d4510.1PTHLH, KRT13, IVL, TFRC
44thymidine45 2411.0PDGFRA, CSF3, TFF1, TFRC, IVL, EPCAM
45gemcitabine45 50 1111.9KDR, EGFR, CSF3
46vegf459.8PDGFRA, CSF3, TFF1, TFRC, EGFR, IVL
47paraffin459.8PDGFRA, TFF1, TFRC, EGFR, IVL, EPCAM
48calcium45 50 11 2412.8PDGFRA, TFF1, CRTC1, IVL, ANXA8L2, ANXA8
49tyrosine459.7PDGFRA, CSF3, TFRC, EGFR, IVL, HCK
50retinoic acid45 2410.4CEACAM7, PDGFRA, CSF3, TFF1, TFRC, EGFR

GO Terms for genes affiliated with Adenosquamous Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:04509510.1KRT13, KRT7, KRT5

Biological processes related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.3KDR, CSF3, PDGFRA
2surfactant homeostasisGO:04312910.3KDR, PTHLH
3peptidyl-tyrosine phosphorylationGO:01810810.3KDR, HCK, PDGFRA
4protein autophosphorylationGO:04677710.3PDGFRA, EGFR, HCK, KDR
5positive regulation of ERK1 and ERK2 cascadeGO:07037410.2KDR, EGFR, PDGFRA
6epidermis developmentGO:00854410.1PTHLH, KRT13, KRT5
7modulation by virus of host morphology or physiologyGO:01904810.0PDGFRA, TFRC, CRTC1, HCK, KDR, KRT7
8positive regulation of cell proliferationGO:00828410.0PTHLH, PDGFRA, CSF3, EGFR, HCK, EPCAM
9positive regulation of actin cytoskeleton reorganizationGO:200025110.0HCK, CSF3

Molecular functions related to Adenosquamous Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:03808510.3KDR, PDGFRA
2transmembrane receptor protein tyrosine kinase activityGO:00471410.3KDR, EGFR, PDGFRA
3protein tyrosine kinase activityGO:00471310.2KDR, HCK, EGFR
4vascular endothelial growth factor-activated receptor activityGO:00502110.2PDGFRA, KDR
5receptor signaling protein tyrosine kinase activityGO:00471610.0KDR, EGFR

Products for genes affiliated with Adenosquamous Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adenosquamous Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet