MCID: ADN009
MIFTS: 48

Adenosquamous Carcinoma malady

Cancer diseases category

Summaries for Adenosquamous Carcinoma

About this section


Wikipedia:63 Adenosquamous carcinoma is a type of cancer that contains two types of cells: squamous cells (thin, flat... more...

MalaCards based summary: Adenosquamous Carcinoma, also known as mixed adenocarcinoma and squamous carcinoma, is related to cervical adenosquamous carcinoma and adenocarcinoma. An important gene associated with Adenosquamous Carcinoma is EPCAM (epithelial cell adhesion molecule), and among its related pathways are Cardiac Progenitor Differentiation and Angiogenesis. The compounds exotoxin-a and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and cervix, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Disease Ontology:9 A squamous cell carcinoma that contains squamous cells and gland-like cells.

Aliases & Classifications for Adenosquamous Carcinoma

About this section
Sources:
9Disease Ontology, 11DISEASES, 60UMLS, 43Novoseek, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Adenosquamous Carcinoma, Aliases & Descriptions:

Name: Adenosquamous Carcinoma 9 11 60
Mixed Adenocarcinoma and Squamous Carcinoma 9
 
Adenosquamous Cell Carcinoma 9
Carcinoma Adenosquamous 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:4830
MeSH33 D018196
SNOMED-CT55 59367005, 403902008
NCIt38 C3727

Related Diseases for Adenosquamous Carcinoma

About this section

Diseases related to Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1cervical adenosquamous carcinoma31.7HCK
2adenocarcinoma30.8PTHLH, KDR, EPCAM, EGFR
3gastrointestinal stromal tumor30.3KDR, PDGFRA
4endometriosis30.2TFRC, KDR, PDGFRA
5large cell carcinoma30.1PTHLH, EGFR
6hepatocellular carcinoma30.1PDGFRA, EPCAM, KDR
7lung cancer29.9KDR, EPCAM, PDGFRA, EGFR
8breast cancer29.4EGFR, EPCAM, KDR, PTHLH
9pancreatitis10.7
10cervicitis10.7
11gastric adenosquamous carcinoma10.7
12prostatitis10.7
13hypercalcemia10.5
14esophageal adenosquamous carcinoma10.5
15glassy cell variant cervical adenosquamous carcinoma10.4
16thymus adenosquamous carcinoma10.4
17endometrial adenosquamous carcinoma10.4
18bartholin's gland adenosquamous carcinoma10.4
19ampulla of vater adenosquamous carcinoma10.4
20cervical adenocarcinoma10.4
21thyroiditis10.4
22gliosarcoma10.4TFRC
23hepatitis10.3
24adenosquamous cell lung carcinoma10.3
25adenoma10.3
26cystic teratoma10.3
27esophagitis10.3
28laryngitis10.3
29teratoma10.3
30neuroendocrine carcinoma10.2
31duodenitis10.2
32mucoepidermoid carcinoma10.2
33adenoiditis10.2
34adenosquamous colon carcinoma10.2
35adenosquamous breast carcinoma10.2
36adenosquamous gallbladder carcinoma10.2
37adenosquamous pancreas carcinoma10.2
38adenosquamous prostate carcinoma10.2
39breast metaplastic carcinoma10.2
40renal cell carcinoma10.2EGFR
41merkel cell carcinoma10.2KDR, EPCAM
42diarrhea10.2EGFR
43kidney cancer10.1EPCAM, KDR
44angiosarcoma10.1KDR, PDGFRA
45hodgkin lymphoma10.1
46pancreatic ductal adenocarcinoma10.1
47sinusitis10.1
48cystadenoma10.1
49sebaceous adenoma10.1
50good syndrome10.1

Graphical network of the top 20 diseases related to Adenosquamous Carcinoma:



Diseases related to adenosquamous carcinoma

Symptoms for Adenosquamous Carcinoma

About this section

Drugs & Therapeutics for Adenosquamous Carcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Adenosquamous Carcinoma

Search NIH Clinical Center for Adenosquamous Carcinoma

Genetic Tests for Adenosquamous Carcinoma

About this section

Anatomical Context for Adenosquamous Carcinoma

About this section

MalaCards organs/tissues related to Adenosquamous Carcinoma:

31
Pancreas, Lung, Cervix, Colon, Liver, Breast, Prostate, Skin, Ovary, Thyroid, Tongue, Small intestine, Testes, Lymph node, Bone, Spleen, Uterus, Testis, T cells

Animal Models for Adenosquamous Carcinoma or affiliated genes

About this section

Publications for Adenosquamous Carcinoma

About this section

Articles related to Adenosquamous Carcinoma:

(show top 50)    (show all 447)
idTitleAuthorsYear
1
Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas. (25830031)
2015
2
Calvaria and orbital metastases of pulmonary adenosquamous carcinoma in a cat: a diagnostic challenge. (25648372)
2015
3
Differential clinical characteristics, treatment response and prognosis of locally advanced adenocarcinoma/adenosquamous carcinoma and squamous cell carcinoma of cervix treated with definitive radiotherapy. (24666257)
2014
4
Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. (24973941)
2014
5
Low-grade adenosquamous carcinoma of the breast with diverse expression patterns of myoepithelial cell markers on immunohistochemistry: a case study. (25013422)
2014
6
Adenosquamous Carcinoma of the Lung: CT, FDG PET, and Clinicopathologic Findings. (23751831)
2014
7
Adenosquamous carcinoma of vesicovaginal fistula: a rare entity. (24876979)
2014
8
MUC1 and bcl-2 expression in preinvasive lesions and adenosquamous carcinoma of the lung. (23550464)
2013
9
Adenosquamous carcinoma of the pancreas: multidetector-row computed tomographic manifestations and tumor characteristics. (23493198)
2013
10
Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro. (23962337)
2013
11
Therapeutic efficacy of gefitinib and erlotinib in patients with advanced lung adenosquamous carcinoma. (23769878)
2013
12
Thymidylate synthase expression and molecular alterations in adenosquamous carcinoma of the lung. (22996376)
2013
13
Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma. (22497449)
2012
14
Oral adenosquamous carcinoma: evidence that it arises from the surface mucosal epithelium. (22690906)
2012
15
Cutaneous metastases of cervical adenosquamous carcinoma. (20633787)
2010
16
Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity. (20697320)
2010
17
Primary gastric adenosquamous carcinoma in a Caucasian woman: a case report. (21034475)
2010
18
Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1. (19152726)
2009
19
Adenosquamous carcinoma of the skin: a case series. (19841403)
2009
20
Clinicopathologic features and outcomes following surgery for pancreatic adenosquamous carcinoma. (18764955)
2008
21
Adenosquamous carcinoma of the nasal cavity. (19006059)
2008
22
Adenosquamous carcinoma of the pancreas: a single-institution experience comparing resection and palliative care. (18722942)
2008
23
Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature. (16515628)
2006
24
Primary adenosquamous carcinoma of the jejunum. (16143036)
2005
25
Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. (14627990)
2003
26
Adenosquamous carcinoma of the liver: clinicopathologic study of 10 surgically treated cases. (12616431)
2003
27
Primary adenosquamous carcinoma of the liver: case report. (12658415)
2002
28
Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible. (12115390)
2002
29
Adenosquamous carcinoma of the pancreas: successful treatment with extended radical surgery, intraoperative radiation therapy, and locoregional chemotherapy. (11558633)
2001
30
Advanced adenosquamous carcinoma of the gallbladder with bilio-biliary fistula: an uncommon case treated by hepatopancreatoduodenectomy. (10430314)
1999
31
Adenosquamous carcinoma of the pancreas. (10367867)
1999
32
Low-grade adenosquamous carcinoma of the breast: a case report with cytologic findings and review of the literature. (9103219)
1997
33
A primary adenosquamous carcinoma of the liver with an elevated level of serum squamous cell carcinoma related antigen. (8799411)
1996
34
Clear cell adenosquamous carcinoma of the cervix. An aggressive tumor associated with human papillomavirus-18. (8635063)
1995
35
Primary adenosquamous carcinoma of the colon. (8823993)
1995
36
Adenosquamous carcinoma of the thyroid: a case report and review of the literature. (7673806)
1995
37
The pathology of low-grade adenosquamous carcinoma of the breast. An immunohistochemical study. (7936747)
1994
38
Polypoid adenosquamous carcinoma of the esophagus with prominent spindle cells. Report of a case with immunohistochemical and ultrastructural studies. (7683870)
1993
39
A matched study of surgically treated stage IB adenosquamous carcinoma and adenocarcinoma of the uterine cervix. (11578353)
1993
40
Liver adenosquamous carcinoma invading the esophagogastric junction - a case-report and a review of the literature. (21584617)
1992
41
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991
42
A phase II clinical trial of diaziquone (AZQ) in the treatment of patients with recurrent adenocarcinoma and adenosquamous carcinoma of the cervix. A Gynecologic Oncology Group study. (2599803)
1989
43
Human papillomavirus DNA in adenosquamous carcinoma and squamous cell carcinoma of the vulva. (2837709)
1988
44
Adenosquamous carcinoma of the stomach. Histogenetic and ultrastructural studies. (3556988)
1987
45
A biologically active parathyroid hormone-like substance secreted by an adenosquamous carcinoma of the transverse colon. (3679201)
1987
46
Adenosquamous carcinoma of the prostate. (3555133)
1987
47
Evaluation of squamous epithelium in adenoacanthoma and adenosquamous carcinoma of the endometrium: immunoperoxidase analysis of involucrin and keratin localization. (6203856)
1984
48
Hyperamylasemia due to poorly differentiated adenosquamous carcinoma of the ovary. (6162432)
1981
49
Test and teach. Number twenty-eight. Diagnosis: adenosquamous carcinoma of the stomach. (7220093)
1981
50
Adenosquamous carcinoma of the cecum arising in endometriosis. (7372199)
1980

Variations for Adenosquamous Carcinoma

About this section

Expression for genes affiliated with Adenosquamous Carcinoma

About this section
Search GEO for disease gene expression data for Adenosquamous Carcinoma.

Pathways for genes affiliated with Adenosquamous Carcinoma

About this section

Pathways related to Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4PDGFRA, KDR
29.4KDR, PDGFRA
3
Show member pathways
Angiogenesis36
9.4PDGFRA, KDR
49.2EGFR, HCK
59.2HCK, EGFR
69.2PDGFRA, EGFR
79.2EGFR, PDGFRA
89.1EGFR, TFRC
9
Show member pathways
9.0EGFR, KDR
109.0EGFR, KDR
11
Show member pathways
8.6HCK, KDR, EGFR
12
Show member pathways
8.6EGFR, KDR, HCK
13
Show member pathways
8.6EGFR, PDGFRA, KDR
14
Show member pathways
8.6EGFR, PDGFRA, KDR
15
Show member pathways
8.6EGFR, PDGFRA, KDR
16
Show member pathways
8.6EGFR, PDGFRA, KDR
17
Show member pathways
8.6EGFR, PDGFRA, KDR
18
Show member pathways
8.6EGFR, PDGFRA, KDR
19
Show member pathways
8.6EGFR, PDGFRA, KDR
20
Show member pathways
8.6KDR, PDGFRA, EGFR
21
Show member pathways
8.6KDR, PDGFRA, EGFR
22
Show member pathways
8.6KDR, PDGFRA, EGFR
23
Show member pathways
8.6KDR, PDGFRA, EGFR
24
Show member pathways
8.6KDR, PDGFRA, EGFR
25
Show member pathways
8.6KDR, PDGFRA, EGFR
268.6KDR, PDGFRA, EGFR
278.6KDR, PDGFRA, EGFR
28
Show member pathways
8.6KDR, PDGFRA, EGFR
298.2EGFR, PDGFRA, KDR, HCK
30
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.2HCK, KDR, PDGFRA, EGFR
318.1TFRC, KDR, PDGFRA, EGFR
32
Show member pathways
8.1EGFR, PDGFRA, KDR, PTHLH

Compounds for genes affiliated with Adenosquamous Carcinoma

About this section

Compounds related to Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1exotoxin-a439.9EPCAM, TFRC
2pkc 412439.8PDGFRA, KDR
3pazopanib49 1210.7PDGFRA, KDR
4ponatinib49 1210.7PDGFRA, KDR
5ptk787439.4KDR, EGFR
6pki-166439.4KDR, EGFR
7pd153035439.4EGFR, PTHLH
8quinazoline439.4EGFR, KDR
9zd6474439.4EGFR, KDR
10vandetanib49 1210.4EGFR, KDR
11su5416439.4EGFR, KDR
12dasatinib43 49 1211.4EGFR, HCK
13calcitriol43 59 24 1212.3PDGFRA, PTHLH, TFRC
14taxane439.3KDR, EGFR
15tgf beta1439.3PTHLH, KDR, PDGFRA
16folate439.2TFRC, KDR, PDGFRA
17marimastat43 59 1211.2EGFR, KDR
18ag-1296439.1PTHLH, PDGFRA, EGFR
19polysaccharide439.1TFRC, HCK, KDR
20cetuximab43 49 1211.1EGFR, KDR
21herbimycin a43 5910.1EGFR, HCK, TFRC
22trastuzumab43 49 1211.1EGFR, EPCAM, KDR
23indomethacin43 28 59 1212.0KDR, PTHLH, TFRC
24erlotinib43 49 1211.0EGFR, KDR
25sunitinib43 49 1211.0EGFR, PDGFRA, KDR
26regorafenib49 1210.0KDR, PDGFRA, EGFR
27gf 109203x43 5910.0EGFR, PTHLH, TFRC
285fluorouracil439.0KDR, EPCAM, EGFR
29progestin438.9EGFR, KDR, PTHLH
30suramin43 28 1210.9EGFR, KDR, TFRC
31agar438.8PTHLH, KDR, EGFR
32n acetylcysteine438.8TFRC, KDR, EGFR
33tamoxifen43 49 28 1211.7PTHLH, KDR, EGFR
34imatinib43 49 1210.6HCK, KDR, PDGFRA, EGFR
35phosphotyrosine438.6HCK, KDR, PDGFRA, EGFR
36ly294002438.5TFRC, KDR, EGFR
37adp43 28 2410.5EGFR, PDGFRA, KDR, HCK
38rapamycin438.5TFRC, KDR, PDGFRA, EGFR
39Adenosine triphosphate24 129.5HCK, KDR, PDGFRA, EGFR
40thymidine43 249.4PDGFRA, EPCAM, KDR, PTHLH, TFRC
41paclitaxel43 49 1210.4EGFR, KDR, PTHLH, TFRC
42doxorubicin43 49 1210.4EGFR, KDR, TFRC
43cisplatin43 49 59 1211.4EGFR, KDR, PTHLH, TFRC
44genistein43 28 59 2 24 1213.2EGFR, KDR, TFRC
45vegf438.0TFRC, PTHLH, KDR, PDGFRA, EGFR
46estrogen437.9TFRC, PTHLH, KDR, PDGFRA, EGFR
47paraffin437.6EGFR, PDGFRA, EPCAM, KDR, PTHLH, TFRC
48phosphatidylinositol437.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR
49retinoic acid43 248.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR
50tyrosine437.6TFRC, HCK, PTHLH, KDR, PDGFRA, EGFR

GO Terms for genes affiliated with Adenosquamous Carcinoma

About this section

Cellular components related to Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.8PDGFRA, KDR, TFRC
2endosomeGO:00057688.5EGFR, KDR, TFRC
3cell surfaceGO:00099868.5TFRC, EPCAM, EGFR
4plasma membraneGO:00058867.7EGFR, PDGFRA, EPCAM, KDR, TFRC

Biological processes related to Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1signal transduction involved in regulation of gene expressionGO:00230199.9PDGFRA, EPCAM
2surfactant homeostasisGO:00431299.6PTHLH, KDR
3lung alveolus developmentGO:00482869.5KDR, PTHLH
4positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5PDGFRA, KDR
5regulation of cell shapeGO:00083609.4KDR, HCK
6positive regulation of DNA replicationGO:00457409.4PDGFRA, EGFR
7positive regulation of fibroblast proliferationGO:00481469.3EGFR, PDGFRA
8lung developmentGO:00303249.2EGFR, PDGFRA
9positive regulation of ERK1 and ERK2 cascadeGO:00703748.9EGFR, PDGFRA, KDR
10positive regulation of cell migrationGO:00303358.8EGFR, PDGFRA, KDR
11viral processGO:00160328.7TFRC, HCK, KDR, PDGFRA
12positive regulation of protein phosphorylationGO:00019348.7EGFR, KDR
13negative regulation of apoptotic processGO:00430668.7HCK, KDR, EGFR
14innate immune responseGO:00450878.7HCK, PDGFRA, EGFR
15peptidyl-tyrosine phosphorylationGO:00181088.5HCK, KDR, PDGFRA, EGFR
16protein autophosphorylationGO:00467778.5HCK, KDR, PDGFRA, EGFR
17positive regulation of cell proliferationGO:00082847.6EGFR, PDGFRA, EPCAM, KDR, PTHLH, HCK

Molecular functions related to Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor bindingGO:00380859.5PDGFRA, KDR
2vascular endothelial growth factor-activated receptor activityGO:00050219.5PDGFRA, KDR
3receptor signaling protein tyrosine kinase activityGO:00047169.0EGFR, KDR
4integrin bindingGO:00051789.0EGFR, KDR
5transmembrane receptor protein tyrosine kinase activityGO:00047148.8EGFR, PDGFRA, KDR
6protein tyrosine kinase activityGO:00047138.7HCK, KDR, EGFR
7ATP bindingGO:00055248.1HCK, KDR, PDGFRA, EGFR
8protein bindingGO:00055157.0TFRC, HCK, KDR, EPCAM, PDGFRA, EGFR

Products for genes affiliated with Adenosquamous Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Adenosquamous Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet