Adhd malady

NINDS: Attention deficit-hyperactivity disorder (ADHD) is a neurobehavioral disorder that affects 3-5 percent of all American children. It interferes with a person's ability to stay on a task and to exercise age-appropriate inhibition (cognitive alone or both cognitive and behavioral). Some of the warning signs of ADHD include failure to listen to instructions, inability to organize oneself and school work, fidgeting with hands and feet, talking too much, leaving projects, chores and homework unfinished, and having trouble paying attention to and responding to details. There are several types of ADHD: a predominantly inattentive subtype, a predominantly hyperactive-impulsive subtype, and a combined subtype. ADHD is usually diagnosed in childhood, although the condition can continue into the adult years.³¹

MalaCards: Adhd, also known as attention deficit hyperactivity disorder, is related to attention deficit hyperactivity disorder and eating disorder. An important gene associated with Adhd is TPH2 (tryptophan hydroxylase 2), and among its related pathways are Cyclophosphamide Pathway, Pharmacodynamics and Fatty acid metabolism. The drugs nortriptyline hydrochloride and bupropion hydrobromide and the compounds methylphenidate and tyramine have been mentioned in the context of this disorder. Affiliated tissues include brain and cerebellum, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

CDC: People with ADHD may have trouble paying attention, controlling impulsive behaviors (may act without thinking about what the result will be), or be overly active. Although ADHD can't be cured, it can be successfully managed and some symptoms may improve as the child ages.²

Wikipedia: Attention deficit-hyperactivity disorder (ADHD) is a psychiatric and neurobehavioral disorder...⁴⁴ more...

adhd 31 attention deficit hyperactivity disorder 43

Diseases related to adhd by text searches and GeneDecks gene sharing:

(show top 50)    (show all 282)

id	Related Disease	Score	Top Affiliating Genes
1	attention deficit hyperactivity disorder	37.9	DRD4, ADHD4, ADHD1, ADHD3, ADHD2
2	eating disorder	33.5	CNR1, BDNF, HTR1A, HTR2A, NTRK2, COMT
3	conduct disorder	32.4	MAOA, HTR1B, SLC6A4
4	rett syndrome	30.8	BDNF, S100B, TPH1, DRD2, NGF, TH
5	panic disorder	30.8	BDNF, CHRNA4, MAOA, HTR1A, HTR1B, HTR2A
6	parkinson's disease	30.1	CNR1, PAWR, BDNF, CHRNA7, CHRNA4, AOC3
7	tourette syndrome	30.0	CNR1, CNTNAP2, BTBD9, BDNF, GTS, MEIS1
8	substance abuse	29.6	CNR1, BDNF, MOBP, GTS, MAOA, MAOB
9	alcoholism	29.6	CNR1, GRIN1, GRIN2A, MAOA, MAOB, HTR1A
10	personality disorder	28.9	MAOA, MAOB, HTR1B, TPH1, TPH2, DRD2
11	pathological gambling	28.8	GRIN1, MAOA, MAOB, DRD1, DRD2, DRD3
12	post-traumatic stress disorder	28.6	CNR1, BDNF, MAOA, DRD2, DBH
13	alcohol abuse	28.4	GTS, ANKK1, HTR1B, HTR2A, DRD2, DRD3
14	autism spectrum disorder	28.3	CNR1, CNTNAP2, BDNF, CHRNA7, CHRNA4, AR
15	cocaine dependence	27.8	CNR1, PAWR, ANKK1, MAOB, HTR2C, CALY
16	seasonal affective disorder	27.5	HTR1A, HTR2A, HTR2C, TPH1, DRD4, PRL
17	schizophrenia	27.4	KALRN, ANKK1, MAOA, HTR2A, TNF, DRD2
18	twinning	26.6	BDNF, ATXN1, AR, INS, FGD1, IL6
19	cerebritis	26.2	CNR1, CNTNAP2, BDNF, CHRNA7, CHRNA4, B3GAT1
20	bulimia nervosa	26.1	CNR1, BDNF, INS, MAOA, HTR1B, HTR2A
21	thyroiditis	25.5	LIG4, ZBTB16, B3GAT1, S100B, ATXN1, ITGA11
22	major depressive disorder	23.9	CNR1, MYT1L, BDNF, CHRNA7, S100B, MOBP
23	alcohol dependence	23.7	CNR1, BDNF, S100B, CDH13, GRIN1, GRIN2A
24	hypertension	22.7	CNR1, CNTNAP2, BDNF, CHRNA7, S100B, KALRN
25	neuronitis	22.6	CNR1, CNTNAP2, KIRREL3, PCDHA@, RBFOX1, LPHN3
26	obesity	20.7	CNR1, RBFOX1, BDNF, CES1, AR, GTS
27	conduction disease	14.2	MAOA, DRD4, DRD5, DBH, SLC6A3, SLC6A4
28	gilles de la tourette syndrome	14.2	CNTNAP2, GTS, HTR3B, DRD2, DRD4, DRD5
29	novelty seeking personality	14.1	MAOA, DRD2, DRD4, COMT, SLC6A2
30	antisocial personality disorder	14.1	ANKK1, MAOA, HTR1B, HTR2A, HTR3B, DRD2
31	dyslexia	14.0	CNTNAP2, ATP2C2, DYX1C1, DRD2, DRD3, DRD4
32	drug addiction	14.0	BDNF, DRD1, DRD2, DRD3, HCRT, SLC6A3
33	manic-depressive illness	13.9	MAOA, MAOB, TPH1, DRD2, DRD3, DRD4
34	social phobia	13.9	MAOA, HTR1A, DRD2, COMT, SLC6A4
35	aggressive digital papillary adenocarcinoma	13.9	MAOA, MAOB, HTR1A, HTR1B, TPH1, DRD2
36	migraine with aura	13.9	HTR1B, HTR2A, HTR2C, DRD2, DBH, SLC6A3
37	neurotic disorder	13.9	BDNF, MAOA, HTR1A, HTR2A, DRD2, DRD3
38	growth mental deficiency syndrome of myhre	13.9	BDNF, MAOA, HTR2C, DRD2, DRD3, DRD4
39	dysthymic disorder	13.9	MAOA, HTR2A, HCRT
40	endogenous depression	13.9	BDNF, HTR1A, DRD3, SLC6A4
41	postural orthostatic tachycardia syndrome	13.9	NOS1, AGT, DBH, SLC6A2, ADRA2C
42	alcoholic psychosis	13.9	HTR2A, SLC6A3, SLC6A4
43	substance dependence	13.9	CNR1, BDNF, FGD1, ANKK1, MAOA, HTR1B
44	orthostatic hypotension	13.8	MAOA, MAOB, DDC, DBH
45	bipolar disorder	13.8	BDNF, HTR1A, SLC6A4
46	essential tremor	13.8	BTBD9, HNMT, TPH1, DRD3, CYP2D6, COMT
47	opiate dependence	13.8	DRD2, DRD3, COMT, TH
48	generalized anxiety disorder	13.8	MAOA, HTR1A, HTR2A, HTR2C, TPH1, SLC6A2
49	anxiety-related personality traits	13.8	BDNF, COMT, NGF, SLC6A4
50	tic disorder	13.8	HTR2A, DRD2, DRD4

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amphetamine, amphetamine adipate, amphetamine aspartate, amphetamine sulfate, amphetamine/dextroamphetamine resin complex, atomoxetine, atomoxetine hcl, bupropion, bupropion hydrobromide, bupropion hydrochloride, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, desipramine, desipramine hydrochloride, dexmethylphenidate, dexmethylphenidate hydrochloride, dextroamphetamine, dextroamphetamine adipate, dextroamphetamine saccharate, dextroamphetamine sulfate, imipramine, imipramine hydrochloride, imipramine pamoate, methylphenidate, methylphenidate hydrochloride, modafinil, nortriptyline, nortriptyline hydrochloride, pemoline, selegiline, selegiline hydrochloride, venlafaxine, venlafaxine hydrochloride

MalaCards organs/tissues related to adhd:

²²

MGI Mouse Phenotypes related to adhd:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	10.7	CNTNAP2, CNR1, SLC6A3, ADH7, SLC6A1, NGFR
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	DBH, OXTR, PIWIL4, SNAP25, NRG3, DRD5
3	normal phenotype	MP:0002873	7.7	REEP5, ADRA2A, SLC6A4, SLC6A1, PRKG1, OXTR
4	renal/urinary system phenotype	MP:0005367	7.5	DDC, DRD5, DRD3, DRD2, MAN2A2, FADS2
5	respiratory system phenotype	MP:0005388	7.4	NTRK2, TPH2, TPH1, GIT1, MAN2A2, IL6
6	reproductive system phenotype	MP:0005389	7.4	HTR1B, TNF, AK8, MAN2A2, MAP1B, FADS2
7	muscle phenotype	MP:0005369	7.3	SNAP25, NTF3, AR, HTR1B, ATXN1, KDM4D
8	vision/eye phenotype	MP:0005391	7.0	DRD5, DRD4, DRD1, TNF, MAP1B, IL6
9	adipose tissue phenotype	MP:0005375	6.9	AGT, NOS1, PTPRD, INS, CREB5, DRD3
10	cardiovascular system phenotype	MP:0005385	6.2	TH, AGT, HCRT, NGFR, COMT, TNF
11	integument phenotype	MP:0010771	6.0	MEIS1, AR, MMP24, GRIN2A, S100B, CHRNA4
12	growth/size phenotype	MP:0005378	5.9	RBFOX1, DRD2, ADORA2A, SLC6A4, SLC6A1, SLC6A3
13	nervous system phenotype	MP:0003631	5.4	TACR1, TDO2, THRB, TH, AGT, HCRT
14	homeostasis/metabolism phenotype	MP:0005376	4.6	RBFOX1, CNR1, LPHN3, ADH5, DNM1, THRB
15	mortality/aging	MP:0010768	3.9	TNF, MEIS1, IL6, FADS2, THRB, MAP1B
16	behavior/neurological phenotype	MP:0005386	3.5	PRL, PKD1L3, NGF, POMC, CREB5, GDNF

Articles related to adhd:

(show top 50)    (show all 258)

id	Title	Authors	Year	Affiliating Genes
1	GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. (21499268)	Won H.... Kim E.	2011	GIT1
2	Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1 ,923 controls from four European populations. (20213726)	Johansson S.... Haavik J.	2010	TPH1, TPH2
3	Toward a better understanding of ADHD: LPHN3 gene var iants and the susceptibility to develop ADHD. (21432600)	Arcos-Burgos M.... Muenke M.	2010	LPHN3
4	Evidence that genetic variation in the oxytocin recep tor (OXTR) gene influences social cognition in ADHD. (20347913)	Park J.... Kent L.	2010	OXTR
5	Screening of human LPHN3 for variants with a potentia l impact on ADHD susceptibility. (21077132)	DomenAc S.... Muenke M.	2010	LPHN3
6	Is NOS1 a genetic link between RLS and ADHD? (19552920)	Reif A.	2010	NOS1
7	Multicenter analysis of the SLC6A3/DAT1 VNTR haplotyp e in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD. (19890261)	Franke B.... Reif A.	2010	SLC6A3
8	No causal role for the G482T and G689T polymorphisms in translation regulation of serotonin transporter (SLC6A4) or association with attention-deficit-hyperactivity disorder (ADHD). (19429092)	Banerjee E.... Nandagopal K.	2009	SLC6A4
9	Association between a SLC6A3 intron 8 VNTR functional polymorphism and ADHD in a Brazilian sample of adult patients. (20098830)	Silva M.A.... Vallada H.	2009	SLC6A3
10	Association of COMT (Val158Met) and BDNF (Val66Met) g ene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. (19582565)	Gadow K.D.... Hatchwell E.	2009	COMT, BDNF
11	CREM mutations and ADHD symptoms. (19201103)	Lahti T.A.... Partonen T.	2009	CREM
12	Genetics of attention-deficit hyperactivity disorder (ADHD). (19715710)	Sharp S.I.... Gurling H.M.	2009	SLC6A3
13	Effects of maternal and paternal smoking on attentional control in children with and without ADHD. (19288168)	Altink M.E.... Buitelaar J.K.	2009	SLC6A3
14	Alertness and feeding behaviors in ADHD: does the hypocretin/orexin system play a role? (18678446)	Cortese S.... Lecendreux M.	2008	HCRT
15	Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. (17525975)	Brookes K.J.... Asherson P.	2008	DRD4
16	Association of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHD. (17948872)	Tharoor H.... Reiersen A.M.	2008	SLC6A3, CHRNA4, SLC6A4
17	Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (18428117)	Conner A.C.... Thome J.	2008	NTRK2, NTRK3, BDNF
18	Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (18951430)	Anney R.J.... Gill M.	2008	LIG4, YWHAZ, FZD7
19	Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region. (19076634)	Wigg K.G.... Barr C.L.	2008	DYX1C1, PRTG
20	Association between trypotphan hydroxylase 2, performance on a continuance performance test and response to methylphenidate in ADHD participants. (18213624)	Manor I.... Ebstein R.P.	2008	TPH2
21	A functional serotonin transporter promoter gene polymorphism increases ADHD symptoms in delinquents: interaction with adverse childhood environment. (18155777)	Retz W.... Rosler M.	2008	SLC6A4
22	A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD. (18951431)	Monuteaux M.C.... Biederman J.	2008	DRD4
23	Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. (17579349)	Lasky-Su J.... Faraone S.	2008	DRD4
24	Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? (17671965)	Ballon N.... Poirier M.F.	2007	DRD2, SLC6A3, DRD3
25	Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test. (17560555)	Lasky-Su J.... Faraone S.V.	2007	DRD4
26	Support for the MnlI polymorphism of SNAP25; a Korean ADHD case-control study. (17325713)	Choi T.K.... Suh S.Y.	2007	SNAP25
27	A study of how socioeconomic status moderates the relationship between SNPs encompassing BDNF and ADHD symptom counts in ADHD families. (17216343)	Lasky-Su J.... Biederman J.	2007	BDNF
28	Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): Analysis of data from the international multicenter ADHD genetics (IMAGE) program. (18163388)	Anney R.J.... Gill M.	2007	DDC, SLC6A2, TPH2
29	Inferring candidate genes for attention deficit hyperactivity disorder (ADHD) assessed by the World Health Organization Adult ADHD Self-Report Scale (ASRS). (16362639)	Reuter M.... Hennig J.	2006	COMT, HTR2A
30	Association between DRD4 gene and performance of children with ADHD in a test of sustained attention. (16781678)	Kieling C.... Rohde L.A.	2006	DRD4
31	COMT Val108/158Met gene variant, birth weight, and conduct disorder in children with ADHD. (17075359)	Sengupta S.M.... Joober R.	2006	COMT
32	Obesity and ADHD may represent different manifestations of a common environmental oversampling syndrome: a model for revealing mechanistic overlap among cognitive, metabolic, and inflammatory disorders. (15905045)	Bazar K.A.... Doux J.D.	2006	INS
33	Genetic background of ADHD: population studies, genes of the catecholamine system (16756025)	Sl/opien A.... Hauser J.	2006	COMT, MAOA, ADRA1A
34	Sleep and COMT polymorphism in ADHD children: preliminary actigraphic data. (16865041)	Gruber R.... Joober R.	2006	COMT
35	Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD. (16917950)	Mick E.... Sklar P.	2006	SLC6A3
36	ADHD and the dopamine transporter: are there reasons to pay attention? (16722244)	Mazei-Robinson M.S.... Blakely R.D.	2006	SLC6A3
37	Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD. (14755441)	Mill J.... Asherson P.	2004	DRD5
38	Adrenergic alpha 2C receptor genomic organization: association study in adult ADHD. (15108182)	De Luca V.... Kennedy J.L.	2004	ADRA2C
39	Phenotype studies of the DRD4 gene polymorphisms in ADHD: association with oppositional defiant disorder and positive family history. (15389763)	Kirley A.... Hawi Z.	2004	DRD4
40	Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. (15007392)	Mill J.... Asherson P.	2004	SNAP25
41	Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. (14699430)	Kustanovich V.... Nelson S.F.	2004	DRD5, DRD4
42	Recent genetic advances in ADHD and diagnostic and th erapeutic prospects. (19810930)	Hawi Z.... Gill M.	2003	DRD4
43	Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci. (12660802)	Hawi Z.... Gill M.	2003	DBH, SLC6A3, DRD5
44	Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis. (12232786)	Kent L.... Craddock N.	2002	SLC6A4
45	No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population. (12210284)	McEvoy B.... Gill M.	2002	SLC6A2
46	Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: evidence of association but no linkage in a UK sample. (11443530)	Mill J.... Asherson P.	2001	DRD4
47	Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population. (11443526)	Hawi Z.... Gill M.	2001	DDC
48	Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. (10402503)	Comings D.E.... MacMurray J.P.	1999	DRD4
49	Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. (10490706)	Eisenberg J.... Ebstein R.P.	1999	COMT
50	Serotonin and the biochemical genetics of alcoholism: lessons from studies of attention deficit hyperactivity disorder (ADHD) and Tourette syndrome. (7748306)	Comings D.E.	1993	TDO2

Genes related to adhd according to GeneCards:

(show top 50)    (show all 176)

id	Symbol	Description	Score	GeneCards Section Context
1	TPH2	tryptophan hydroxylase 2	11.0	Publications, Aliases & Descriptions
2	CNTNAP2	contactin associated protein-like 2	11.0	Summaries
3	ADHD6	Attention deficit-hyperactivity disorder, susceptibility to, 6	10.9	Gene
4	ADHD5	Attention deficit-hyperactivity disorder, susceptibility to, 5	10.9	Gene
5	ADHD4	Attention deficit-hyperactivity disorder, susceptibility to, 4	10.9	Gene
6	ADHD2	Attention deficit-hyperactivity disorder, susceptibility to, 2	10.9	Gene
7	ADHD3	Attention deficit-hyperactivity disorder, susceptibility to, 2	10.9	Gene
8	LOC401646	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 pseudogene	10.9
9	ADHD1	Attention deficit-hyperactivity disorder, susceptibility to, 1	10.9	Gene
10	NT3	3'-nucleotidase	10.9	Publications
11	LOC729984	heterogeneous nuclear ribonucleoprotein A1-like	10.9	Publications
12	RSL24D1P11	ribosomal L24 domain containing 1 pseudogene 11	10.9	Publications
13	LOC100130842	chromosome 19 open reading frame 42 pseudogene	10.9
14	CYCSP6	cytochrome c, somatic pseudogene 6	10.9	Publications
15	GTS	Gilles de la Tourette syndrome	10.9	Publications
16	SPATA8	spermatogenesis associated 8	10.9	Publications
17	TAAR9	trace amine associated receptor 9 (gene/pseudogene)	10.9	Publications
18	DRD4	dopamine receptor D4	10.9	Publications
19	GSX1	GS homeobox 1	10.9	Publications
20	ETV3L	ets variant 3-like	10.9	Publications
21	DRD5	dopamine receptor D5	10.9	Publications
22	C5orf15	chromosome 5 open reading frame 15	10.9	Publications
23	GPR85	G protein-coupled receptor 85	10.9	Publications
24	ETV3	ets variant 3	10.9	Publications
25	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	10.9	Publications
26	PCDHA@	protocadherin alpha cluster, complex locus	10.9	Publications
27	C12orf28	chromosome 12 open reading frame 28	10.9	Publications
28	FZD7	frizzled family receptor 7	10.9	Publications
29	ADH6	alcohol dehydrogenase 6 (class V)	10.9	Orthologs
30	KDM4D	lysine (K)-specific demethylase 4D	10.9	Publications
31	ABHD13	abhydrolase domain containing 13	10.9	Publications
32	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	10.9	Publications
33	MATN1	matrilin 1, cartilage matrix protein	10.9	Publications
34	ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	10.9	Orthologs
35	ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	10.9	Orthologs
36	RIT1	Ras-like without CAAX 1	10.9	Publications
37	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	10.9	Publications
38	CRYGC	crystallin, gamma C	10.9	Publications
39	CORO1A	coronin, actin binding protein, 1A	10.9	Publications
40	DYX1C1	dyslexia susceptibility 1 candidate 1	10.9	Publications
41	CALY	calcyon neuron-specific vesicular protein	10.9	Publications
42	C16orf46	chromosome 16 open reading frame 46	10.9	Publications
43	ADRA2A	adrenoceptor alpha 2A	10.9	Publications
44	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	10.9	Publications
45	DHODH	dihydroorotate dehydrogenase (quinone)	10.9	Publications
46	FLJ39061	uncharacterized protein FLJ39061	10.9	Publications
47	IST1	increased sodium tolerance 1 homolog (yeast)	10.9	Publications
48	MAN2A2	mannosidase, alpha, class 2A, member 2	10.9	Publications
49	SNAP25	synaptosomal-associated protein, 25kDa	10.9	Publications
50	ANKK1	ankyrin repeat and kinase domain containing 1	10.9	Publications

Pathways related to adhd according to GeneDecks:

(show all 43)

id	Pathway	Score	Top Affiliating Genes
1	Cyclophosphamide Pathway, Pharmacodynamics34	10.9	ADH1A, ADH1C, ADH5, ADH7, ADH4, ADH1B
2	Fatty acid metabolism20	10.9	ADH1C, ADH1B, ADH4, ADH7, ADH1A, ADH6
3	Glycolysis / Gluconeogenesis20	10.9	ADH1B, ADH7, ADH1A, ADH1C, ADH5, ADH6
4	Metabolism of xenobiotics by cytochrome P45020	10.9	ADH4, ADH6, ADH7, ADH1B, ADH1A, ADH1C
5	Retinol metabolism20	10.8	ADH7, ADH5, ADH6, CYP2A6, ADH1B, ADH4
6	Tryptophan metabolism20	10.8	TDO2, DDC, TPH2, TPH1, MAOB, MAOA
7	Tyrosine metabolism20	10.8	AOC3, MAOA, MAOB, DDC, ADH5, PNMT
8	Drug metabolism - cytochrome P45020	10.8	MAOA, ADH4, ADH5, ADH7, ADH6, MAOB
9	Biological oxidations38	10.7	CYP2A6, ADH6, ADH1C, CYP2D6, ADH7, ADH4
10	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.7	TPH1, HTR2A, TPH2, HTR1A, MAOA, HTR1E
11	Tyrosine metabolism p.1 (dopamine)41	10.7	AOC3, MAOA, MAOB, DDC, PNMT, COMT
12	Tyrosine metabolism p.1 (dopamine)10	10.7	ADH1B, AOC3, DBH, MAOA, TH, COMT
13	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	10.7	SNAP25, DRD3, DDC, DRD4, TH, DRD2
14	Sympathetic Nerve Pathway (Neuroeffector Junction)34	10.7	DDC, TH, DBH, SLC6A2, ADRA2C, ADRA1A
15	Amine ligand-binding receptors38	10.6	ADRA1A, HTR1A, HTR1B, HTR1E, HTR2C, DRD1
16	Metabolic pathways20	10.5	ADH7, TH, ADH1C, ADH5, ADH1A, ADH6
17	Celecoxib Pathway, Pharmacokinetics34	10.5	ADH1A, CYP2D6, ADH1B
18	CDK5 Pathway36	10.5	DRD5, DRD1, DRD2, DRD3, BDNF, DRD4
19	Phenylalanine metabolism20	10.4	AOC3, MAOA, MAOB, DDC
20	Metabolism of amino acids and derivatives38	10.3	DDC, TH, PNMT, TPH1, TPH2, TDO2
21	Dopamine-DARPP32 Feedback onto cAMP Pathway36	10.1	DRD3, DRD4, DRD2, GRIN2A, GRIN1, DRD5
22	Development MAG-dependent inhibition of neurite outgrowth10	10.0	NTF3, NTRK3, NGF, NGFR, NTRK2, BDNF
23	Development Neurotrophin family signaling10	10.0	NGFR, NGF, NTRK3, NTRK2, NTF3, BDNF
24	Development_Neurotrophin family signaling41	10.0	BDNF, NTF3, NGF, NTRK3, NGFR, NTRK2
25	Calcium signaling pathway20	10.0	ADORA2A, TACR1, NOS1, GRIN1, CHRNA7, GRIN2A
26	Actin-Based Motility by Rho Family GTPases36	9.9	BDNF, ITGA11, ITGAE, GPC6, NRG3, NGFR
27	Development_MAG-dependent inhibition of neurite outgrowth41	9.9	NTRK3, BDNF, NTF3, NTRK2, NGF, NGFR
28	Neurotrophin signaling pathway20	9.8	NTF3, BDNF, NGF, MAP2K5, NTRK2, NGFR
29	Ras Pathway36	9.5	MAP2K5, NET1, NRG3, ITGAE, ITGA11, NTRK2
30	Neuroactive ligand-receptor interaction20	9.5	ADRA2C, PRL, OXTR, TACR1, TAAR9, THRB
31	Neuroscience3	9.2	DBH, CNTNAP2, S100B, ATXN1, GRIN1, GRIN2A
32	Rap1 Pathway36	8.9	IL6, ITGAE, ITGA11, BDNF, GPC6, NTF3
33	ERK5 Signaling36	8.9	YWHAZ, IL6, GPC6, BDNF, NTF3, NTRK3
34	Rac1 Pathway36	8.9	ITGAE, BDNF, ITGA11, GPC6, NTF3, NTRK2
35	DHA Signaling36	8.8	NTF3, NGFR, NRG3, NTRK3, NTRK2, YWHAZ
36	Activation of PKA through GPCR36	8.7	BDNF, CREM, YWHAZ, IL6, NTF3, NTRK2
37	Intracellular Calcium Signaling36	8.6	HTR1E, GRIN2A, CHRNA4, CHRNA7, BDNF, IL6
38	Apoptotic Pathways in Synovial Fibroblasts36	8.6	NTF3, NTRK2, BDNF, TNF, NTRK3, NRG3
39	PPAR Pathway36	8.6	IL6, GPC6, NGFR, TNF, NRG3, NTRK3
40	14-3-3 Induced Intracellular Signaling36	8.5	NRG3, NTRK3, BDNF, YWHAZ, MAP2K5, GPC6
41	Cellular Apoptosis Pathway36	8.5	NRG3, NTRK3, NTRK2, NTF3, GPC6, IL6
42	p70S6K Signaling36	8.1	BDNF, YWHAZ, INS, IL6, MAP2K5, GPC6
43	eIF2 Pathway36	8.1	NTF3, NTRK3, IL6, NTRK2, GPC6, INS

Compounds related to adhd according to GeneDecks:

(show top 50)    (show all 306)

id	Compound	Score	Top Affiliating Genes
1	methylphenidate32 9 9	12.8	MAOA, ADRA2A, SLC6A4, SLC6A3, SLC6A2, TH
2	tyramine32 18	11.6	ADRA2A, SLC6A2, TH, COMT, CYP2D6, MAOB
3	methamphetamine32 9 9	12.6	ADRA2A, ADRA2C, SLC6A4, SLC6A3, SLC6A2, TH
4	Methotrimeprazine9 9	11.6	ADRA2A, ADRA1A, ADRA2C, CYP2D6, DRD5, DRD4
5	amine32	10.6	SLC6A4, SLC6A2, DBH, SYP, COMT, PNMT
6	ropinirole32 9 9	12.5	HTR2A, HTR1B, HTR1A, MAOB, HTR2C, DRD1
7	nicotine32 34 9 9	13.5	ANKK1, CYP2A6, SLC6A2, CYP2D6
8	6-hydroxydopamine32	10.5	MAOA, BDNF, MAOB, DRD1, GDNF, SLC6A3
9	maoa32	10.5	HTR1A, MAOB, MAOA, BDNF, SLC6A4, SLC6A3
10	mhpg32	10.5	SLC6A4, SLC6A2, PRL, DBH, TH, COMT
11	homovanillic acid32 18	11.4	BDNF, SLC6A4, SLC6A2, PRL, DBH, TH
12	imipramine32 34 9 18 9	14.3	ADRA1A, BDNF, MAOA, SLC6A4, SLC6A3, SLC6A2
13	amphetamine32 9 9	12.3	GDNF, SLC6A4, SLC6A3, SLC6A2, POMC, TH
14	cabergoline32 9 9	12.2	DRD3, DRD2, DRD1, HTR2C, HTR2A, HTR1B
15	paroxetine32 34 9 9	13.2	SLC6A4, SLC6A3, SLC6A2, PRL, TACR1, COMT
16	lisuride32 9 9	12.2	DRD1, HTR2C, HTR2A, HTR1B, HTR1A, DRD2
17	pramipexole32 9 9	12.2	DRD1, HTR2C, HTR2A, HTR1B, HTR1A, BDNF
18	risperidone32 34 9 18 9	14.2	ADRA2C, SLC6A4, SLC6A3, PRL, COMT, CYP2D6
19	aripiprazole32 34 9 18 9	14.2	DRD1, HTR2C, HTR2A, HTR1E, HTR1B, HTR1A
20	desipramine32 34 9 9	13.1	CYP2D6, CYP2A6, HTR2A, HTR1A, MAOA, CNR1
21	mptp32	10.1	GDNF, ADORA2A, SLC6A4, BDNF, CHRNA7, GRIN1
22	ziprasidone32 9 9	12.1	ADRA1A, ADRA2C, PRL, CYP2D6, DRD5, DRD4
23	mdma32	10.1	SLC6A4, SLC6A3, SLC6A2, PRL, TH, CYP2D6
24	pergolide32 9 9	12.1	ADRA2A, ADRA1A, ADRA2C, PRL, COMT, CYP2D6
25	clomipramine32 34 9 9	13.1	SLC6A4, SLC6A3, SLC6A2, PRL, TACR1, HCRT
26	paliperidone32 9 9	12.1	DRD4, DRD3, DRD2, DRD1, HTR2C, HTR2A
27	apomorphine32 9 9	12.1	DRD2, DRD1, CALY, HTR2C, HTR2A, HTR1B
28	quetiapine32 9 18 9	13.0	ADRA2A, ADORA2A, ADRA1A, ADRA2C, SLC6A3, PRL
29	catecholamine32	9.9	GDNF, DRD4, DRD3, DRD1, TPH1, MAOB
30	citalopram32 34 9 18 9	13.9	CYP2D6, CYP2A6, TPH1, HTR2C, HTR2A, HTR1A
31	trimipramine32 34 9 9	12.8	ADRA1A, HTR1A, HTR2A, DRD1, DRD2, PRL
32	choline32 9 18 9	12.8	ADH1A, CHRNA7, ADRA2A, ADH7, ADH1B, SYP
33	fluoxetine32 34 9 9	12.7	HTR2A, HTR1B, HTR1A, MAOB, MAOA, BDNF
34	ethanol32 34 9 18 9	13.6	SLC6A2, CES1, S100B, CHRNA7, BDNF, GRIN1
35	bromocriptine32 9 9	11.5	ADRA2A, ADRA1A, ADRA2C, POMC, PRL, DDC
36	5-hydroxytryptamine32	9.5	ADORA2A, SLC6A4, SLC6A3, SLC6A2, POMC, PRL
37	clozapine32 34 9 9	12.5	HTR2C, HTR2A, HTR1E, HTR1A, ANKK1, CHRNA7
38	olanzapine32 34 9 18 9	13.4	CYP2D6, DRD5, DRD4, DRD3, DRD2, DRD1
39	levodopa32 9 9	11.4	ADORA2A, SLC6A3, PRL, DBH, TH, NGF
40	haloperidol32 34 9 9	12.2	ADORA2A, SLC6A4, SLC6A1, SLC6A3, SLC6A2, POMC
41	gaba32 42	9.9	GDNF, ADORA2A, SLC6A4, SLC6A1, SLC1A1, SLC6A3
42	histamine32 18	9.7	BDNF, CNR1, NGFR, NGF, NOS1, PNMT
43	nmda32 42	9.6	NTRK2, NTF3, DRD3, DRD2, DRD1, HTR2C
44	acetylcholine32 9 18 9	11.6	NOS1, PNMT, SNAP25, NTF3, CYP2D6, DRD2
45	glutamate32	8.6	ADH5, ADRA2A, SLC6A1, SLC1A1, TACR1, TH
46	cocaine32 9 9	10.3	DRD4, DRD3, DRD2, CNR1, BDNF, S100B
47	dopamine32 9 18 9	11.0	TACR1, TH, AGT, HCRT, NGFR, NGF
48	epinephrine32 9 18 9	11.0	DDC, DRD4, DRD2, MAOB, MAOA, AOC3
49	norepinephrine32 9 18 9	10.0	GDNF, ADRA2A, ADORA2A, ADRA1A, ADRA2C, SLC6A4
50	tyrosine32	5.7	DBH, OXTR, DHODH, SYP, TDO2, THRB

Cellular components related to adhd according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	10.1	HTR3B, DBH, SNAP25, DRD1, NTRK2, DDC
2	axon	GO:030424	9.9	DRD2, DRD1, DDC, CTNNA2, KIRREL3, HTR3B
3	postsynaptic density	GO:014069	9.8	YWHAZ, ADORA2A, DRD2, MAP1B, GRIN2A, GRIN1
4	terminal button	GO:043195	9.7	DBH, NTRK2, DRD4, GRIN2A, GRIN1
5	integral to plasma membrane	GO:005887	7.8	CNR1, DRD1, DRD2, DRD3, DRD4, DRD5
6	plasma membrane	GO:005886	7.6	GRIN2A, SLC6A4, ADRA2A, ADORA2A, CNR1, FGD1

Biological processes related to adhd according to GeneDecks:

(show top 50)    (show all 53)

id	Name	GO ID	Score	Top Affiliating Genes
1	dopamine catabolic process	GO:042420	11.0	SLC6A3, COMT, MAOA, DBH
2	ethanol oxidation	GO:006069	11.0	ADH1A, ADH6, ADH5, ADH7, ADH1C, ADH4
3	fear response	GO:042596	11.0	BDNF, DBH, ADRA2A, DRD4
4	social behavior	GO:035176	10.8	SLC6A4, DBH, OXTR, DRD4, DRD3, GRIN1
5	regulation of dopamine secretion	GO:014059	10.8	DRD2, DRD3, CHRNA4, HTR1B, HTR2A
6	behavioral response to cocaine	GO:048148	10.8	DRD3, DRD4, DRD1, DRD2
7	response to histamine	GO:034776	10.8	DRD4, DRD3, DRD2
8	synaptic transmission, dopaminergic	GO:001963	10.8	DRD1, DRD5, TH, ADORA2A, DRD3, DRD2
9	xenobiotic metabolic process	GO:006805	10.8	ADH6, ADH1A, COMT, ADH7, ADH4, ADH1B
10	serotonin biosynthetic process	GO:042427	10.8	TPH1, TPH2, DDC
11	phospholipase C-activating dopamine receptor signaling pathway	GO:060158	10.7	DRD5, DRD2, DRD1
12	locomotory behavior	GO:007626	10.7	CHRNA4, DRD2, ADORA2A, SLC6A3, DBH, TH
13	regulation of dopamine uptake involved in synaptic transmission	GO:051584	10.7	GDNF, DRD3, DRD1, DRD2
14	catecholamine biosynthetic process	GO:042423	10.7	DBH, TH, PNMT, DDC
15	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO:007195	10.7	DRD2, DRD3, DRD4
16	neurotransmitter biosynthetic process	GO:042136	10.7	COMT, TH, NOS1, MAOA, SLC6A3
17	behavioral response to ethanol	GO:048149	10.6	DBH, DRD4, DRD2
18	dopamine metabolic process	GO:042417	10.6	DRD4, GRIN2A, DRD3, DRD2, DRD1
19	eating behavior	GO:042755	10.6	ADORA2A, OXTR, TACR1, HCRT, DRD1
20	response to cocaine	GO:042220	10.6	SLC6A1, OXTR, SLC6A3, CNR1, GRIN2A, HTR1B
21	indolalkylamine biosynthetic process	GO:046219	10.6	TPH2, TPH1, DDC
22	response to amphetamine	GO:001975	10.6	ADORA2A, DBH, OXTR, DRD5, DRD4, GRIN1
23	visual learning	GO:008542	10.6	GRIN1, GRIN2A, DBH, DRD2, DRD5, DRD1
24	peristalsis	GO:030432	10.6	DRD2, AGT, DRD1, GDNF
25	monoamine transport	GO:015844	10.6	SLC6A4, SLC6A3, SLC6A2
26	regulation of dopamine metabolic process	GO:042053	10.5	DRD4, SLC6A3, DRD1
27	response to morphine	GO:043278	10.5	CNR1, DRD3, TACR1, DRD2, GRIN1
28	positive regulation of renal sodium excretion	GO:035815	10.5	DRD2, ADORA2A, AGT, TACR1
29	sleep	GO:030431	10.5	GRIN2A, HTR2A, SNAP25, OXTR
30	behavior	GO:007610	10.5	MAOA, HTR1A, TACR1, CNR1, CNTNAP2
31	synaptic transmission	GO:007268	10.5	GRIN1, HTR3B, SLC6A2, DRD5, SNAP25, COMT
32	prepulse inhibition	GO:060134	10.5	CTNNA2, DRD3, GRIN1, SLC6A3, ADORA2A, DRD2
33	positive regulation of synaptic transmission, glutamatergic	GO:051968	10.5	ADORA2A, OXTR, NTRK2, DRD1
34	response to nicotine	GO:035094	10.4	CNR1, TACR1, NGF, DRD2, CHRNA7, SLC6A3
35	learning	GO:007612	10.4	DRD3, SLC6A1, TH, COMT, NTRK2
36	adenohypophysis development	GO:021984	10.4	GSX1, SLC6A3, DRD2
37	regulation of long-term neuronal synaptic plasticity	GO:048169	10.4	GRIN1, DRD1, DRD2, DRD5, AGT, SYP
38	mechanoreceptor differentiation	GO:042490	10.3	BDNF, NTF3, NTRK2
39	response to ethanol	GO:045471	10.3	CNR1, GRIN2A, MAOB, TACR1, DRD3, GRIN1
40	regulation of neurotransmitter secretion	GO:046928	10.3	DRD4, NGF, HCRT, NTRK2
41	sensory perception of pain	GO:019233	10.2	CNR1, GRIN2A, HTR2A, NGF, TACR1, GRIN1
42	negative regulation of neuron apoptotic process	GO:043524	10.1	NGF, LIG4, ADORA2A, AGT, NTRK2, GDNF
43	dopamine biosynthetic process	GO:042416	10.0	DDC, TH, SLC6A3
44	memory	GO:007613	10.0	SLC6A4, CNR1, CHRNA7, S100B, GRIN2A, DRD1
45	negative regulation of protein secretion	GO:050709	10.0	DRD2, INS, DRD4, DRD3
46	positive regulation of apoptotic process	GO:043065	9.6	NET1, GRIN1, AGT, CNR1, PAWR, ZBTB16
47	response to drug	GO:042493	9.6	DRD3, COMT, MAP1B, BDNF, NGF, OXTR
48	G-protein coupled receptor signaling pathway	GO:007186	9.4	DRD3, HTR1B, HTR1E, ADRA1A, ADRA2C, TAAR9
49	small molecule metabolic process	GO:044281	9.3	ARSE, B3GAT1, RGL1, AGT, TDO2, DHODH
50	positive regulation of MAPK cascade	GO:043410	8.7	IL6, AR, INS, NTRK2, AGT, ADRA1A

Molecular functions related to adhd according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	alcohol dehydrogenase (NAD) activity	GO:004022	10.8	ADH5, ADH1C, ADH1A, ADH7, ADH4, ADH6
2	dopamine binding	GO:035240	10.8	DRD4, DRD1, DRD2, DRD3, DRD5, SLC6A3
3	alcohol dehydrogenase activity, zinc-dependent	GO:004024	10.7	ADH4, ADH1B, ADH1A, ADH7
4	dopamine receptor activity	GO:004952	10.7	DRD5, DRD4, DRD1
5	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.5	DRD2, DRD4, DRD3
6	monoamine transmembrane transporter activity	GO:008504	10.5	SLC6A4, SLC6A3, SLC6A2
7	amino acid binding	GO:016597	10.5	TDO2, DDC, TPH2, TPH1
8	primary amine oxidase activity	GO:008131	10.4	MAOB, MAOA, AOC3
9	serotonin binding	GO:051378	10.4	HTR2A, HTR1E, HTR2C, HTR1B, HTR1A, MAOA
10	serotonin receptor activity	GO:004993	10.4	HTR1A, HTR1B, HTR2C, HTR2A, HTR3B, HTR1E
11	drug binding	GO:008144	10.3	SLC6A3, CYP2D6, DRD5, DRD4, DRD2, DRD1
12	iron ion binding	GO:005506	9.8	TDO2, TH, NOS1, CYP2D6, CYP2A6, TPH1