MCID: ADP002
MIFTS: 38

Adiponectin Deficiency malady

Genetic diseases (common) category
Download this MalaCard

Summaries for Adiponectin Deficiency

About this section
Sources:
47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Adiponectin Deficiency is related to insulin resistance and vascular disease. An important gene associated with Adiponectin Deficiency is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are G-Beta Gamma Signaling and Oxytocin signaling pathway. The compounds adma and metoprolol have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and endothelial, and related mouse phenotypes are other and adipose tissue.

Description from OMIM:47 612556

Aliases & Classifications for Adiponectin Deficiency

About this section
Sources:
47OMIM, 62UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

adiponectin deficiency 47 62


Related Diseases for Adiponectin Deficiency

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Adiponectin Deficiency:



Diseases related to adiponectin deficiency

Symptoms for Adiponectin Deficiency

About this section
Sources:
47OMIM
See all sources


Clinical features from OMIM:

612556

Drugs & Therapeutics for Adiponectin Deficiency

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Adiponectin Deficiency

Search NIH Clinical Center for Adiponectin Deficiency

Genetic Tests for Adiponectin Deficiency

About this section

Anatomical Context for Adiponectin Deficiency

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Adiponectin Deficiency:

33
Liver, Colon, Endothelial, Brain, Heart, Skeletal muscle, Nk cells, T cells

Animal Models for Adiponectin Deficiency or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Adiponectin Deficiency:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.0NOS3, PTGS2
2MP:00053758.7NOS3, ADIPOQ, PTGS2
3MP:00053708.7PTGS2, ADIPOQ, NOS3
4MP:00053678.6NOS3, ADIPOQ, PTGS2
5MP:00053888.6PTGS2, ADIPOQ, NOS3
6MP:00053698.5NOS3, ADIPOQ, PTGS2
7MP:00053798.4PTGS2, ADIPOQ, NOS3
8MP:00053908.2NOS3, ADIPOQ, PTGS2

Publications for Adiponectin Deficiency

About this section
Sources:
52PubMed
See all sources

Articles related to Adiponectin Deficiency:

(show all 33)
idTitleAuthorsYear
1
Insulin resistance by adiponectin deficiency: is the action in skeletal muscle? (23431015)
2013
2
Adiponectin deficiency blunts hypoxia-induced mobilization and homing of circulating angiogenic cells. (24288546)
2013
3
Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer. (23474825)
2013
4
Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. (24113220)
2013
5
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. (23530146)
2013
6
Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. (21996662)
2012
7
Adiponectin deficiency: role in chronic inflammation induced colon cancer. (22198319)
2012
8
Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. (21976521)
2011
9
Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models. (21063900)
2011
10
Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. (19850745)
2010
11
Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. (19915153)
2010
12
Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation. (19583972)
2010
13
Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload. (20348222)
2010
14
Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration. (20700533)
2010
15
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response. (20206634)
2010
16
Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis. (19481767)
2010
17
Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice. (20155376)
2010
18
Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. (19375615)
2009
19
Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. (19561137)
2009
20
Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice. (19564844)
2009
21
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. (19168697)
2009
22
Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in the transfer model of colitis. (19520591)
2009
23
Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice. (19074637)
2009
24
Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. (19447866)
2009
25
Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. (19027750)
2009
26
Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. (18628355)
2008
27
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. (19030198)
2008
28
Adiponectin deficiency protects mice from chemically induced colonic inflammation. (17258715)
2007
29
Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver. (17936760)
2007
30
Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. (17549259)
2007
31
Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in mice. (16901963)
2006
32
Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (16733851)
2006
33
Insulin resistance after prenatal growth restriction: is it mediated by adiponectin deficiency? (16649963)
2006

Variations for Adiponectin Deficiency

About this section
Sources:
64UniProtKB/Swiss-Prot
See all sources

UniProtKB/Swiss-Prot genetic disease variations for Adiponectin Deficiency:

64
id Symbol AA change Variation ID SNP ID
1ADIPOQp.Arg112CysVAR_013274

Expression for genes affiliated with Adiponectin Deficiency

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Adiponectin Deficiency

Search GEO for disease gene expression data for Adiponectin Deficiency.

Pathways for genes affiliated with Adiponectin Deficiency

About this section
Sources:
50PathCards, 53QIAGEN, 30KEGG, 60Thomson Reuters, 54R&D Systems, 38NCBI BioSystems Database, 5Cell Signaling Technology
See all sources

Pathways related to Adiponectin Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0NOS3, PTGS2
2
Show member pathways
9.0NOS3, PTGS2
3
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
9.0PTGS2, NOS3
4
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0NOS3, PTGS2
59.0NOS3, PTGS2

Compounds for genes affiliated with Adiponectin Deficiency

About this section
Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience
See all sources

Compounds related to Adiponectin Deficiency according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1adma459.8NOS3, ADIPOQ
2metoprolol45 51 29 24 1113.8NOS3, ADIPOQ
3candesartan45 51 29 1112.7ADIPOQ, NOS3
4amlodipine45 51 24 1112.7NOS3, ADIPOQ
5rosuvastatin45 51 29 1112.7ADIPOQ, NOS3
68-isoprostane459.7NOS3, ADIPOQ
7aicar45 24 1111.7ADIPOQ, NOS3
8streptozotocin459.7NOS3, ADIPOQ
9fenofibrate45 51 1111.7ADIPOQ, NOS3
10pravastatin45 51 29 24 1113.7NOS3, ADIPOQ
11palmitate459.7NOS3, ADIPOQ
12homocysteine45 2410.7ADIPOQ, NOS3
13sodium nitroprusside459.6ADIPOQ, NOS3
14atorvastatin45 51 29 24 1113.6ADIPOQ, NOS3
15rosiglitazone29 45 51 24 1113.6NOS3, ADIPOQ
16citrate459.6NOS3, ADIPOQ
172-arachidonoylglycerol45 2910.6ADIPOQ, PTGS2
18drospirenone45 29 51 1112.6ADIPOQ, PTGS2
19simvastatin45 51 61 29 24 1114.6NOS3, ADIPOQ
20folate459.5ADIPOQ, NOS3
21etanercept45 51 1111.5ADIPOQ, PTGS2
22thapsigargin45 6110.5NOS3, ADIPOQ
23prostaglandin f2alpha459.5ADIPOQ, PTGS2
24pioglitazone29 45 51 1112.5PTGS2, ADIPOQ
25glycerol45 24 1111.4ADIPOQ, NOS3
26tetrahydrobiopterin45 24 1111.4NOS3, PTGS2
27ciglitazone45 2910.4PTGS2, NOS3
28methotrexate51 45 1111.4NOS3, ADIPOQ
2915-deoxy-delta-12,14-prostaglandin j2459.4NOS3, PTGS2
30troglitazone45 29 61 1112.4PTGS2, ADIPOQ
31mifepristone45 29 61 1112.4NOS3, PTGS2
32ascorbic acid45 2410.3NOS3, ADIPOQ
33gf 109203x45 6110.3NOS3, PTGS2
34acetylcholine45 51 29 24 1113.3NOS3, ADIPOQ
35resveratrol45 61 24 1112.3NOS3, PTGS2
36heme29 24 1111.2NOS3, PTGS2
37vitamin d459.0NOS3, ADIPOQ
38prostacyclin458.9NOS3, ADIPOQ, PTGS2
39aspirin45 51 29 2411.9PTGS2, ADIPOQ, NOS3
40sb 20358045 619.9PTGS2, ADIPOQ, NOS3
41indomethacin45 29 61 1111.9PTGS2, NOS3
42ly294002458.9PTGS2, ADIPOQ, NOS3
43actinomycin d458.9NOS3, ADIPOQ, PTGS2
44estrogen458.8PTGS2, ADIPOQ, NOS3

GO Terms for genes affiliated with Adiponectin Deficiency

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Adiponectin Deficiency according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood pressureGO:0457769.4NOS3, ADIPOQ
2response to tumor necrosis factorGO:0346129.2ADIPOQ, PTGS2
3negative regulation of calcium ion transportGO:0519269.2NOS3, PTGS2
4brown fat cell differentiationGO:0508739.1PTGS2, ADIPOQ
5angiogenesisGO:0015259.0NOS3, PTGS2
6regulation of blood pressureGO:0082178.9NOS3, PTGS2
7response to glucocorticoidGO:0513848.8ADIPOQ, PTGS2

Molecular functions related to Adiponectin Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.0NOS3, PTGS2

Products for genes affiliated with Adiponectin Deficiency

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adiponectin Deficiency

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet