MCID: ADP002
MIFTS: 37

Adiponectin Deficiency malady

Genetic diseases (common) category

Aliases & Classifications for Adiponectin Deficiency

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Adiponectin Deficiency, Aliases & Descriptions:

Name: Adiponectin Deficiency 45 10 60
 
Adiponectin, Serum Level of, Quantitative Trait Locus 1 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM45 612556

Summaries for Adiponectin Deficiency

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MalaCards based summary: Adiponectin Deficiency, also known as adiponectin, serum level of, quantitative trait locus 1, is related to vascular disease and endotheliitis. An important gene associated with Adiponectin Deficiency is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are G-Beta Gamma Signaling and Oxytocin signaling pathway. The compounds adma and metoprolol have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and colon, and related mouse phenotypes are other and adipose tissue.

Description from OMIM:45 612556

Related Diseases for Adiponectin Deficiency

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Graphical network of the top 20 diseases related to Adiponectin Deficiency:



Diseases related to adiponectin deficiency

Symptoms for Adiponectin Deficiency

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Clinical features from OMIM:

612556

Drugs & Therapeutics for Adiponectin Deficiency

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Drug clinical trials:

Search ClinicalTrials for Adiponectin Deficiency

Search NIH Clinical Center for Adiponectin Deficiency

Genetic Tests for Adiponectin Deficiency

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Anatomical Context for Adiponectin Deficiency

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MalaCards organs/tissues related to Adiponectin Deficiency:

31
Liver, Endothelial, Colon, Brain, Heart, Skeletal muscle, Skin, Nk cells, T cells

Animal Models for Adiponectin Deficiency or affiliated genes

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MGI Mouse Phenotypes related to Adiponectin Deficiency:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.0NOS3, PTGS2
2MP:00053758.7NOS3, ADIPOQ, PTGS2
3MP:00053708.7PTGS2, ADIPOQ, NOS3
4MP:00053678.6NOS3, ADIPOQ, PTGS2
5MP:00053888.6PTGS2, ADIPOQ, NOS3
6MP:00053698.5NOS3, ADIPOQ, PTGS2
7MP:00053798.4PTGS2, ADIPOQ, NOS3
8MP:00053908.2NOS3, ADIPOQ, PTGS2

Publications for Adiponectin Deficiency

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Articles related to Adiponectin Deficiency:

(show all 33)
idTitleAuthorsYear
1
Adiponectin Deficiency Contributes to Sensitivity in Human Skin. (25880703)
2015
2
Adiponectin deficiency exacerbates age-related hearing impairment. (24763046)
2014
3
Insulin resistance by adiponectin deficiency: is the action in skeletal muscle? (23431015)
2013
4
Adiponectin deficiency blunts hypoxia-induced mobilization and homing of circulating angiogenic cells. (24288546)
2013
5
Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. (24113220)
2013
6
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. (23530146)
2013
7
Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. (21996662)
2012
8
Adiponectin deficiency: role in chronic inflammation induced colon cancer. (22198319)
2012
9
Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. (21976521)
2011
10
Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models. (21063900)
2011
11
Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. (19850745)
2010
12
Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. (19915153)
2010
13
Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation. (19583972)
2010
14
Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload. (20348222)
2010
15
Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration. (20700533)
2010
16
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response. (20206634)
2010
17
Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis. (19481767)
2010
18
Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice. (20155376)
2010
19
Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. (19375615)
2009
20
Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. (19561137)
2009
21
Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice. (19564844)
2009
22
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. (19168697)
2009
23
Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice. (19074637)
2009
24
Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. (19447866)
2009
25
Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. (19027750)
2009
26
Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. (18628355)
2008
27
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. (19030198)
2008
28
Adiponectin deficiency protects mice from chemically induced colonic inflammation. (17258715)
2007
29
Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver. (17936760)
2007
30
Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. (17549259)
2007
31
Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in mice. (16901963)
2006
32
Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. (16733851)
2006
33
Insulin resistance after prenatal growth restriction: is it mediated by adiponectin deficiency? (16649963)
2006

Variations for Adiponectin Deficiency

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UniProtKB/Swiss-Prot genetic disease variations for Adiponectin Deficiency:

62
id Symbol AA change Variation ID SNP ID
1ADIPOQp.Arg112CysVAR_013274

Expression for genes affiliated with Adiponectin Deficiency

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Search GEO for disease gene expression data for Adiponectin Deficiency.

Pathways for genes affiliated with Adiponectin Deficiency

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Pathways related to Adiponectin Deficiency according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0NOS3, PTGS2
2
Show member pathways
9.0NOS3, PTGS2
3
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
9.0PTGS2, NOS3
4
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0NOS3, PTGS2
59.0NOS3, PTGS2

Compounds for genes affiliated with Adiponectin Deficiency

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Compounds related to Adiponectin Deficiency according to GeneCards Suite gene sharing:

(show all 44)
idCompoundScoreTop Affiliating Genes
1adma439.8NOS3, ADIPOQ
2metoprolol43 49 28 24 1213.8NOS3, ADIPOQ
3candesartan43 49 28 1212.7ADIPOQ, NOS3
4amlodipine43 49 24 1212.7NOS3, ADIPOQ
5rosuvastatin43 49 28 1212.7ADIPOQ, NOS3
68-isoprostane439.7NOS3, ADIPOQ
7aicar43 24 1211.7ADIPOQ, NOS3
8streptozotocin439.7NOS3, ADIPOQ
9fenofibrate43 49 1211.7ADIPOQ, NOS3
10pravastatin43 49 28 24 1213.7NOS3, ADIPOQ
11palmitate439.7NOS3, ADIPOQ
12homocysteine43 2410.7ADIPOQ, NOS3
13sodium nitroprusside439.6ADIPOQ, NOS3
14atorvastatin43 49 28 24 1213.6ADIPOQ, NOS3
15rosiglitazone28 43 49 24 1213.6NOS3, ADIPOQ
16citrate439.6NOS3, ADIPOQ
172-arachidonoylglycerol43 2810.6ADIPOQ, PTGS2
18drospirenone43 28 49 1212.6ADIPOQ, PTGS2
19simvastatin43 49 59 28 24 1214.6NOS3, ADIPOQ
20folate439.5ADIPOQ, NOS3
21etanercept43 49 1211.5ADIPOQ, PTGS2
22thapsigargin43 5910.5NOS3, ADIPOQ
23prostaglandin f2alpha439.5ADIPOQ, PTGS2
24pioglitazone28 43 49 1212.5PTGS2, ADIPOQ
25glycerol43 24 1211.4ADIPOQ, NOS3
26tetrahydrobiopterin43 24 1211.4NOS3, PTGS2
27ciglitazone43 2810.4PTGS2, NOS3
28methotrexate49 43 1211.4NOS3, ADIPOQ
2915-deoxy-delta-12,14-prostaglandin j2439.4NOS3, PTGS2
30troglitazone43 28 59 1212.4PTGS2, ADIPOQ
31mifepristone43 28 59 1212.4NOS3, PTGS2
32ascorbic acid43 2410.3NOS3, ADIPOQ
33gf 109203x43 5910.3NOS3, PTGS2
34acetylcholine43 49 28 24 1213.3NOS3, ADIPOQ
35resveratrol43 59 24 1212.3NOS3, PTGS2
36heme28 24 1211.2NOS3, PTGS2
37vitamin d439.0NOS3, ADIPOQ
38prostacyclin438.9NOS3, ADIPOQ, PTGS2
39aspirin43 49 28 2411.9PTGS2, ADIPOQ, NOS3
40sb 20358043 599.9PTGS2, ADIPOQ, NOS3
41indomethacin43 28 59 1211.9PTGS2, NOS3
42ly294002438.9PTGS2, ADIPOQ, NOS3
43actinomycin d438.9NOS3, ADIPOQ, PTGS2
44estrogen438.8PTGS2, ADIPOQ, NOS3

GO Terms for genes affiliated with Adiponectin Deficiency

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Biological processes related to Adiponectin Deficiency according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood pressureGO:00457769.4NOS3, ADIPOQ
2response to tumor necrosis factorGO:00346129.2ADIPOQ, PTGS2
3negative regulation of calcium ion transportGO:00519269.2NOS3, PTGS2
4brown fat cell differentiationGO:00508739.1PTGS2, ADIPOQ
5angiogenesisGO:00015259.0NOS3, PTGS2
6regulation of blood pressureGO:00082178.9NOS3, PTGS2
7response to glucocorticoidGO:00513848.8ADIPOQ, PTGS2

Molecular functions related to Adiponectin Deficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.0NOS3, PTGS2

Products for genes affiliated with Adiponectin Deficiency

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Sources for Adiponectin Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet