MCID: ADP002
MIFTS: 25

Adiponectin Deficiency malady

Summaries for Adiponectin Deficiency

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46OMIM, 32MalaCards
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MalaCards: Adiponectin Deficiency is related to vascular disease and colon cancer. An important gene associated with Adiponectin Deficiency is ADIPOQ (adiponectin, C1Q and collagen domain containing), and among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Angiogenesis. The compounds adma and metoprolol have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and liver/biliary system.

Description from OMIM:46 612556

Aliases & Classifications for Adiponectin Deficiency

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46OMIM, 60UMLS
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Aliases & Descriptions:

adiponectin deficiency 46 60


Related Diseases for Adiponectin Deficiency

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Adiponectin Deficiency:



Diseases related to adiponectin deficiency

Clinical Features for Adiponectin Deficiency

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46OMIM
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Clinical features from OMIM:

612556

Drugs & Therapeutics for Adiponectin Deficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Adiponectin Deficiency

Drug clinical trials:

Search ClinicalTrials for Adiponectin Deficiency

Search NIH Clinical Center for Adiponectin Deficiency

Search CenterWatch for Adiponectin Deficiency

Genetic Tests for Adiponectin Deficiency

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Anatomical Context for Adiponectin Deficiency

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Animal Models for Adiponectin Deficiency or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Adiponectin Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5ADIPOQ, PTGS2, NOS3
2MP:00053708.2ADIPOQ, PTGS2, NOS3

Publications for Adiponectin Deficiency

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Genetic Variations for Adiponectin Deficiency

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Adiponectin Deficiency:

62
id Symbol AA change Variation ID SNP ID
1ADIPOQp.Arg112CysVAR_013274

Expression for genes affiliated with Adiponectin Deficiency

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adiponectin Deficiency

Search GEO for disease gene expression data for Adiponectin Deficiency.

Pathways for genes affiliated with Adiponectin Deficiency

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Sources:
12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Adiponectin Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0PTGS2, NOS3
29.0PTGS2, NOS3

Compounds for genes affiliated with Adiponectin Deficiency

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Adiponectin Deficiency according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1adma449.7ADIPOQ, NOS3
2metoprolol44 28 49 11 2413.7ADIPOQ, NOS3
3candesartan44 28 1111.7ADIPOQ, NOS3
4amlodipine44 49 11 2412.7NOS3, ADIPOQ
5rosuvastatin44 49 28 1112.7ADIPOQ, NOS3
68-isoprostane449.7ADIPOQ, NOS3
7aicar44 11 2411.7NOS3, ADIPOQ
8streptozotocin449.6ADIPOQ, NOS3
9fenofibrate44 49 1111.6NOS3, ADIPOQ
10pravastatin44 49 28 11 2413.6ADIPOQ, NOS3
11drospirenone44 49 28 1112.5ADIPOQ, PTGS2
12palmitate449.5NOS3, ADIPOQ
132-arachidonoylglycerol44 2810.5ADIPOQ, PTGS2
14sodium nitroprusside449.5ADIPOQ, NOS3
15homocysteine44 2410.5ADIPOQ, NOS3
16atorvastatin44 49 28 11 2413.4NOS3, ADIPOQ
17etanercept44 49 1111.4ADIPOQ, PTGS2
18prostaglandin f2alpha449.4ADIPOQ, PTGS2
19pioglitazone44 49 28 1112.4ADIPOQ, PTGS2
20tetrahydrobiopterin44 11 2411.4PTGS2, NOS3
21ciglitazone44 2810.4PTGS2, NOS3
22simvastatin44 49 59 28 11 2414.3ADIPOQ, NOS3
2315-deoxy-delta-12,14-prostaglandin j2449.3NOS3, PTGS2
24mifepristone44 59 28 1112.3PTGS2, NOS3
25troglitazone44 28 59 1112.1PTGS2, ADIPOQ
26gf 109203x44 5910.1PTGS2, NOS3
27citrate449.0ADIPOQ, NOS3
28prostacyclin448.9ADIPOQ, PTGS2, NOS3
29aspirin44 49 28 2411.9NOS3, PTGS2, ADIPOQ
30sb 20358044 599.9ADIPOQ, PTGS2, NOS3
31ly294002448.9NOS3, PTGS2, ADIPOQ
32actinomycin d448.9ADIPOQ, PTGS2, NOS3
33estrogen448.4ADIPOQ, PTGS2, NOS3

GO Terms for genes affiliated with Adiponectin Deficiency

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16Gene Ontology
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Biological processes related to Adiponectin Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood pressureGO:0457769.3ADIPOQ, NOS3
2response to tumor necrosis factorGO:0346129.2ADIPOQ, PTGS2
3negative regulation of calcium ion transportGO:0519269.1NOS3, PTGS2
4response to glucocorticoid stimulusGO:0513849.1ADIPOQ, PTGS2
5brown fat cell differentiationGO:0508739.0PTGS2, ADIPOQ
6regulation of blood pressureGO:0082178.7NOS3, PTGS2

Molecular functions related to Adiponectin Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.0PTGS2, NOS3

Products for genes affiliated with Adiponectin Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Adiponectin Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet