ADPND
MCID: ADP002
MIFTS: 30

Adiponectin Deficiency (ADPND) malady

Categories: Genetic diseases

Aliases & Classifications for Adiponectin Deficiency

Aliases & Descriptions for Adiponectin Deficiency:

Name: Adiponectin Deficiency 54 66 13 69
Adpnd 66

Classifications:



External Ids:

OMIM 54 612556

Summaries for Adiponectin Deficiency

UniProtKB/Swiss-Prot : 66 Adiponectin deficiency: A condition that results in very low concentrations of plasma adiponectin.

MalaCards based summary : Adiponectin Deficiency, also known as adpnd, is related to abdominal obesity-metabolic syndrome 1 and limb ischemia. An important gene associated with Adiponectin Deficiency is ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing). The drugs Tenofovir and Cholecalciferol have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and colon, and related phenotype is obsolete other.

Description from OMIM: 612556

Related Diseases for Adiponectin Deficiency

Graphical network of the top 20 diseases related to Adiponectin Deficiency:



Diseases related to Adiponectin Deficiency

Symptoms & Phenotypes for Adiponectin Deficiency

Clinical features from OMIM:

612556

MGI Mouse Phenotypes related to Adiponectin Deficiency:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 obsolete other MP:0005395 8.62 ADIPOQ NOS3

Drugs & Therapeutics for Adiponectin Deficiency

Drugs for Adiponectin Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tenofovir Approved, Investigational Phase 4,Phase 3 147127-20-6 464205
2
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 6221 10883523 5280795
3
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
4 Bone Density Conservation Agents Phase 4,Phase 3
5 Ergocalciferols Phase 4,Phase 3
6 Micronutrients Phase 4,Phase 3
7 Trace Elements Phase 4,Phase 3
8 vitamin d Phase 4,Phase 3
9 Vitamins Phase 4,Phase 3
10 Hormone Antagonists Phase 4
11 Hormones Phase 4,Early Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
13 insulin Phase 4,Phase 3
14 Insulin, Globin Zinc Phase 4,Phase 3
15 Anti-HIV Agents Phase 4,Phase 3
16 Anti-Infective Agents Phase 4,Phase 3
17 Anti-Retroviral Agents Phase 4,Phase 3
18 Antiviral Agents Phase 4,Phase 3
19 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
20 Reverse Transcriptase Inhibitors Phase 4,Phase 3
21 Calciferol Nutraceutical Phase 4,Phase 3
22 Vitamin D2 Nutraceutical Phase 4,Phase 3
23
Emtricitabine Approved, Investigational Phase 3 143491-57-0 60877
24
Lopinavir Approved Phase 3 192725-17-0 92727
25
Ritonavir Approved, Investigational Phase 3 155213-67-5 392622
26 Cytochrome P-450 CYP3A Inhibitors Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 3
29 HIV Integrase Inhibitors Phase 3
30 HIV Protease Inhibitors Phase 3
31 Integrase Inhibitors Phase 3
32
protease inhibitors Phase 3
33 Raltegravir Potassium Phase 3
34
Rosiglitazone Approved, Investigational 122320-73-4 77999
35
Pioglitazone Approved, Investigational 111025-46-8 4829
36
Iron Approved 7439-89-6 23925
37
Alfacalcidol Approved, Nutraceutical 41294-56-8 5282181
38
Maleic acid Experimental 110-16-7 444266
39 Antipsychotic Agents
40 Quetiapine Fumarate 111974-72-2
41 Liver Extracts
42 Hypoglycemic Agents
43 Calcifediol 19356-17-3
44 Hydroxycholecalciferols

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Effect of Vitamin D on Metabolic Parameters in Patients With the Metabolic Syndrome Unknown status NCT01237769 Phase 4
2 Growth Hormone and Glucose Metabolism Completed NCT00929799 Phase 4
3 Metabolic Impact Assessment of Tenofovir Disoproxil Fumarate on Non-HIV-1 Infected Healthy Adult Male Volunteers Completed NCT00648817 Phase 4
4 Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel Metabolism Completed NCT01315366 Phase 3
5 Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL) Completed NCT00711009 Phase 3
6 Relationship Between CETP Deficiency and Atherosclerosis in Patients With Hyperalphalipoproteinemia Unknown status NCT01916512
7 Adipocyte Function and Somtropin Deficiency Completed NCT01351818
8 The Influence of Vitamin D on Atypical Antipsychotic-induced Weight Gain Completed NCT02281162
9 Fatty Acid Oxidation Disorders & Body Weight Regulation Grant Completed NCT00654004
10 Vitamin D Supplementation in Psychiatric Illnesses Completed NCT01004354
11 Vitamin D3 Supplementation Pilot Study Completed NCT01546103
12 Evaluating an Exercise Program to Reduce Cardiovascular Risk Factors in Children Infected With HIV Completed NCT00908284
13 Evolution of Interleukin 7, Fat Mass and Metabolic Profile Before and After Transplantation Completed NCT01414660
14 Subclinical Atherosclerosis in HIV-infected Patients Completed NCT00455793
15 Study of Metabolic Syndrome in Adolescent and Young Adult Survivors of Childhood Leukemia Who Have Undergone Stem Cell Transplant Completed NCT00920842
16 HIV and Cardiovascular Risk Completed NCT00465426
17 Rosiglitazone (Avandia®) Treatment in HIV: Its Effect on Blood Vessels Completed NCT00143624
18 Seinäjoki Adult Asthma Study Completed NCT02733016
19 Exercise and Pioglitazone for HIV-Metabolic Syndromes Completed NCT00639457
20 Physiologic Growth Hormone Effects in HIV Lipodystrophy Completed NCT00100698
21 Assessing the Severity of Metabolic-related Liver Injuries in Aging HIV-monoinfected Patients Completed NCT02093754
22 Coronary Artery Disease and Its Association With Liver Steatosis Among HIV-Infected Persons Completed NCT00889577
23 Observational Study of Early Metabolic and Vascular Changes in Obesity Recruiting NCT00482924
24 Lipophilic Micronutrients, Adipokines and Gestational Diabetes Mellitus Recruiting NCT01678469
25 CaREFREE Study (Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study) Recruiting NCT02858336 Early Phase 1
26 Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry Recruiting NCT00574327
27 Role of Vitamin D in the Prevention and Treatment of Diseases Associated With Insulin Resistance Active, not recruiting NCT01779908
28 To Study the Nutri-Genomic Response of Vit-D Supplementation in African-Americans Active, not recruiting NCT02802449

Search NIH Clinical Center for Adiponectin Deficiency

Genetic Tests for Adiponectin Deficiency

Anatomical Context for Adiponectin Deficiency

MalaCards organs/tissues related to Adiponectin Deficiency:

39
Liver, Endothelial, Colon, T Cells, Nk Cells, Brain, Skeletal Muscle

Publications for Adiponectin Deficiency

Articles related to Adiponectin Deficiency:

(show all 40)
id Title Authors Year
1
Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. ( 28073830 )
2017
2
Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. ( 27884163 )
2016
3
Adiponectin Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in Mice. ( 27700136 )
2016
4
Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia. ( 26906634 )
2016
5
Adiponectin Deficiency Contributes to Sensitivity in Human Skin. ( 25880703 )
2015
6
Combined Adiponectin Deficiency and Resistance in Obese Patients: Can It Solve Part of the Puzzle in Nonalcoholic Steatohepatitis. ( 27275239 )
2015
7
Adiponectin deficiency exacerbates age-related hearing impairment. ( 24763046 )
2014
8
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells. ( 23530146 )
2013
9
Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. ( 24113220 )
2013
10
Adiponectin deficiency blunts hypoxia-induced mobilization and homing of circulating angiogenic cells. ( 24288546 )
2013
11
Insulin resistance by adiponectin deficiency: is the action in skeletal muscle? ( 23431015 )
2013
12
Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer. ( 23474825 )
2013
13
Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. ( 21996662 )
2012
14
Adiponectin deficiency: role in chronic inflammation induced colon cancer. ( 22198319 )
2012
15
Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. ( 21976521 )
2011
16
Modulation of lupus phenotype by adiponectin deficiency in autoimmune mouse models. ( 21063900 )
2011
17
Effect of adiponectin deficiency on intestinal damage and hematopoietic responses of mice exposed to gamma radiation. ( 19583972 )
2010
18
Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis. ( 19481767 )
2010
19
Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration. ( 20700533 )
2010
20
Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice. ( 20155376 )
2010
21
Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response. ( 20206634 )
2010
22
Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. ( 19915153 )
2010
23
Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. ( 19850745 )
2010
24
Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload. ( 20348222 )
2010
25
Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in the transfer model of colitis. ( 19520591 )
2009
26
Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. ( 19447866 )
2009
27
Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice. ( 19074637 )
2009
28
Adiponectin deficiency impairs liver regeneration through attenuating STAT3 phosphorylation in mice. ( 19564844 )
2009
29
Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. ( 19375615 )
2009
30
Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. ( 19027750 )
2009
31
Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. ( 19561137 )
2009
32
Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. ( 19168697 )
2009
33
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. ( 19030198 )
2008
34
Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. ( 18628355 )
2008
35
Adiponectin deficiency protects mice from chemically induced colonic inflammation. ( 17258715 )
2007
36
Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. ( 17549259 )
2007
37
Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver. ( 17936760 )
2007
38
Insulin resistance after prenatal growth restriction: is it mediated by adiponectin deficiency? ( 16649963 )
2006
39
Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice. ( 16733851 )
2006
40
Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in mice. ( 16901963 )
2006

Variations for Adiponectin Deficiency

UniProtKB/Swiss-Prot genetic disease variations for Adiponectin Deficiency:

66
id Symbol AA change Variation ID SNP ID
1 ADIPOQ p.Arg112Cys VAR_013274 rs121917815

ClinVar genetic disease variations for Adiponectin Deficiency:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ADIPOQ NM_001177800.1(ADIPOQ): c.-1095G> T single nucleotide variant risk factor rs876661321 GRCh38 Chromosome 3, 186841714: 186841714

Expression for Adiponectin Deficiency

Search GEO for disease gene expression data for Adiponectin Deficiency.

Pathways for Adiponectin Deficiency

GO Terms for Adiponectin Deficiency

Biological processes related to Adiponectin Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of blood pressure GO:0045776 8.62 ADIPOQ NOS3

Sources for Adiponectin Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....