MCID: ADR008
MIFTS: 47

Adrenal Adenoma malady

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Adrenal Adenoma

Aliases & Descriptions for Adrenal Adenoma:

Name: Adrenal Adenoma 12 50 52 14
Adenoma of the Adrenal Gland 12 50
Adrenal Cortical Adenoma 50 69
Adrenal Incidentaloma 50 69
Adrenocortical Adenoma 50

Classifications:



External Ids:

Disease Ontology 12 DOID:656

Summaries for Adrenal Adenoma

NIH Rare Diseases : 50 adenomas of the adrenal gland are non-cancerous (benign) tumors on the adrenal gland. most do not cause any signs or symptoms and rarely require treatment. however, some may become "active" or "functioning" which means they produce hormones, often in excess of what the adrenal glands typically produce. high levels of these hormones can lead to complications, including primary aldosteronism, cushing's syndrome and other medical conditions. functioning adrenal adenomas may be treated with surgery and/or medications. last updated: 11/24/2014

MalaCards based summary : Adrenal Adenoma, also known as adenoma of the adrenal gland, is related to pheochromocytoma and hyperaldosteronism, familial, type ii. An important gene associated with Adrenal Adenoma is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Insulin secretion. The drugs Epinephrine and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

Disease Ontology : 12 An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.

Related Diseases for Adrenal Adenoma

Diseases related to Adrenal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
id Related Disease Score Top Affiliating Genes
1 pheochromocytoma 29.6 CRH MEN1 POMC
2 hyperaldosteronism, familial, type ii 11.0
3 hyperaldosteronism, familial, type iii 10.9
4 adrenal cortical adenoma 10.9
5 adenoma 10.8
6 cushing's syndrome 10.4
7 craniofacial dyssynostosis 10.3 CYP21A2 HSD11B1
8 borderline personality disorder 10.3 CYP17A1 CYP21A2
9 spastic ataxia 3 10.3 CYP11B1 CYP11B2
10 cleft lip palate-tetraphocomelia 10.2 CYP21A2 POMC
11 bent bone dysplasia syndrome 10.2 CYP17A1 CYP21A2
12 deafness, autosomal recessive 29 10.2 CYP11A1 CYP17A1 CYP21A2
13 tick-borne encephalitis 10.2 CYP11A1 CYP17A1 CYP21A2
14 liver sarcoma 10.2 CYP11A1 CYP17A1 CYP21A2
15 dyt1 early-onset isolated dystonia 10.2 CYP17A1 CYP21A2 POMC
16 pelvic muscle wasting 10.2 CYP17A1 CYP21A2 POMC
17 ataxia, spastic, 5, autosomal recessive 10.1 MC2R POMC
18 intermittent squint 10.1 CRH POMC
19 x-linked sideroblastic anemia with ataxia 10.1 CYP11A1 CYP17A1 POMC
20 breast secretory carcinoma 10.1 CRH POMC
21 posterior uveal melanoma 10.1 CYP11B1 CYP21A2 POMC
22 glossopharyngeal nerve neoplasm 10.1 POMC REN
23 endometrial mixed adenocarcinoma 10.1 POMC REN
24 nonparalytic poliomyelitis 10.1 CRH POMC
25 dacryoadenitis 10.1 CRH POMC
26 hypogonadism cardiomyopathy 10.1 CRH POMC
27 microphthalmia, isolated, with coloboma 7 10.1 CYP11B2 CYP21A2 REN
28 adult i blood group with or without congenital cataract 10.1 CRH HSD11B1 POMC
29 femur bifid with monodactylous ectrodactyly 10.1 CRH POMC
30 cardiomyopathy, dilated, 1v 10.1 CYP11A1 CYP11B1 CYP11B2 CYP17A1
31 diabetes insipidus, nephrogenic 10.1 MC2R POMC
32 hypogonadism mitral valve prolapse mental retardation 10.1 CYP11B2 POMC REN
33 epithelial predominant pulmonary blastoma 10.1 CYP11A1 CYP17A1 CYP21A2 POMC
34 cataract 21, multiple types 10.1 HSD11B1 POMC REN
35 hyperaldosteronism 10.1
36 epidemic typhus 10.0 CYP17A1 CYP21A2
37 adrenal cortical adenocarcinoma 10.0 CRH CYP21A2 HSD11B1 POMC
38 astroblastoma 10.0 CRH POMC REN
39 fatty liver disease 10.0 CRH POMC REN
40 familial multiple trichodiscomas 10.0 MC2R POMC REN
41 intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.0 CYP11B1 CYP11B2 MEN1
42 calcinosis 10.0 CRH POMC REN
43 distal monosomy 14q 10.0 CYP11A1 CYP21A2 POMC REN
44 hypoaldosteronism, congenital, due to cmo i deficiency 9.9 CYP11B1 CYP11B2 POMC REN
45 microphthalmia, syndromic 9 9.9 CYP11A1 CYP11B1 CYP17A1 CYP21A2 POMC
46 sphingolipidosis 9.9 CYP17A1 CYP21A2 POMC SULT2A1
47 capillary lymphangioma 9.9 CRH POMC SULT2A1
48 conn's syndrome 9.9
49 mitochondrial complex ii deficiency 9.9 MEN1 POMC
50 pulmonary neuroendocrine tumor 9.9 MEN1 POMC

Graphical network of the top 20 diseases related to Adrenal Adenoma:



Diseases related to Adrenal Adenoma

Symptoms & Phenotypes for Adrenal Adenoma

GenomeRNAi Phenotypes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.83 SULT2A1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.83 CYP21A2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.83 SULT2A1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.83 CYP21A2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.83 SULT2A1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.83 CYP11A1 CYP21A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.83 CYP11A1 CYP21A2 SULT2A1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.83 CYP21A2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.83 CYP21A2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.83 CYP11A1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.83 SULT2A1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.83 SULT2A1
13 Increased transferrin (TF) endocytosis GR00363-A 9.32 CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2 GIPR

MGI Mouse Phenotypes related to Adrenal Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CRH CYP11A1 CYP11B1 CYP17A1 HSD11B1 MC2R
2 endocrine/exocrine gland MP:0005379 10.02 CRH CYP11A1 CYP11B1 CYP11B2 GIPR HSD11B1
3 cardiovascular system MP:0005385 10.01 CYP11A1 CYP11B1 CYP11B2 HSD11B1 MC2R MEN1
4 homeostasis/metabolism MP:0005376 10 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 GIPR
5 growth/size/body region MP:0005378 9.97 CRH CYP11A1 CYP11B1 CYP11B2 HSD11B1 MC2R
6 adipose tissue MP:0005375 9.85 CRH CYP11B2 HSD11B1 MC2R POMC
7 immune system MP:0005387 9.76 CRH CYP11A1 CYP11B2 HSD11B1 MC2R MEN1
8 liver/biliary system MP:0005370 9.43 CRH CYP11A1 CYP11B2 HSD11B1 MEN1 POMC
9 nervous system MP:0003631 9.23 CRH CYP11A1 CYP11B2 HSD11B1 MC2R MEN1

Drugs & Therapeutics for Adrenal Adenoma

Drugs for Adrenal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Butyric Acid Experimental Phase 4 107-92-6 264
5 glucocorticoids Phase 4,Phase 3,Phase 2
6 Mydriatics Phase 4,Phase 3,Phase 2
7 Adrenergic Agents Phase 4,Phase 3,Phase 2
8 Adrenergic Agonists Phase 4,Phase 3,Phase 2
9 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
10 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2
11 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
12 Cortisol succinate Phase 4,Phase 3,Phase 2
13 Hormone Antagonists Phase 4,Phase 3,Phase 2
14 Anesthetics Phase 4,Phase 2,Phase 3
15 Hormones Phase 4,Phase 3,Phase 2
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
18 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
19 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 3,Phase 2
20 Hydrocortisone acetate Phase 4,Phase 3,Phase 2
21 Epinephryl borate Phase 4,Phase 3,Phase 2
22 Hydrocortisone-17-butyrate Phase 4
23 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
24 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
25 Racepinephrine Phase 4,Phase 3,Phase 2
26 Respiratory System Agents Phase 4,Phase 3,Phase 2
27 Autonomic Agents Phase 4,Phase 3,Phase 2
28 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
29 Bronchodilator Agents Phase 4,Phase 3,Phase 2
30
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
31
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
32
Etomidate Approved Phase 2, Phase 3 33125-97-2 36339 667484
33
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
34 Mineralocorticoid Receptor Antagonists Phase 3
35 Mineralocorticoids Phase 3
36 beta-endorphin Phase 3
37 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
38
protease inhibitors Phase 3,Phase 2
39 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
40 Adrenocorticotropic Hormone Phase 3,Phase 2
41 Contraceptive Agents Phase 3
42 Contraceptives, Oral Phase 3
43 Contraceptives, Postcoital Phase 3
44 HIV Protease Inhibitors Phase 3,Phase 2
45 Dexamethasone 21-phosphate Phase 3,Phase 2
46 Antiemetics Phase 3,Phase 2
47 Luteolytic Agents Phase 3
48 Melanocyte-Stimulating Hormones Phase 3
49 BB 1101 Phase 3,Phase 2
50 Anesthetics, General Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 58)
id Name Status NCT ID Phase
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4
2 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4
3 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Active, not recruiting NCT02759718 Phase 4
4 SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Completed NCT01096654 Phase 3
5 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3
6 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3
7 Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome Completed NCT01371565 Phase 3
8 Comparison on the Efficacy of Endoscopic Snare Papillectomy With or Without Submucosal Injection Completed NCT02165852 Phase 3
9 Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? Recruiting NCT01504555 Phase 3
10 Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia Not yet recruiting NCT02010957 Phase 2, Phase 3
11 Dynamic Hormone Diagnostics in Endocrine Disease Not yet recruiting NCT02934399 Phase 2, Phase 3
12 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2
13 A Study to Assess SOM230 in Patients With Pituitary Cushing's Disease Completed NCT00088608 Phase 2
14 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2
15 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Recruiting NCT02468193 Phase 2
16 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Recruiting NCT02804750 Phase 2
17 Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism Active, not recruiting NCT02001051 Phase 2
18 Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition Not yet recruiting NCT03111810 Phase 2
19 A Phase II Study of Pertuzumab and Erlotinib for Metastatic or Unresectable Neuroendocrine Tumors Terminated NCT00947167 Phase 2
20 Study of Pasireotide in Patients With Rare Tumors of Neuroendocrine Origin Terminated NCT00958841 Phase 2
21 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
22 Cixutumumab, Everolimus, and Octreotide Acetate in Treating Patients With Advanced Low to Intermediate Grade Neuroendocrine Carcinoma Completed NCT01204476 Phase 1
23 Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Not yet recruiting NCT02831179 Phase 1
24 D2 Dopamine Receptor on Human Aldosterone-Producing Adenoma and Its Role in Aldosterone Secretion and Cell Proliferation Unknown status NCT00173446
25 Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Unknown status NCT01267747
26 Postoperative Cardiovascular Index Change of Primary Aldosteronism Unknown status NCT00746070
27 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma Completed NCT00768365
28 Adrenalectomy for Solitary Adrenal Gland Metastases Completed NCT01135238
29 Peri-Operative Steriod Management in Patients Completed NCT02084134
30 Intraoperative Analysis of Cortisol During Adrenal Vein Sampling Completed NCT01761344
31 Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism Completed NCT01190501
32 Adrenal Vein Sampling International Study (AVIS Study) Completed NCT01234220
33 The Factors Associated With the Recurrence in Patients With Cushing Disease Completed NCT02233335
34 Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment Completed NCT01728493
35 Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome Completed NCT01688349
36 Visualizing Vascular Endothelial Growth Factor (VEGF) Producing Lesions in Von Hippel-Lindau Disease Completed NCT00970970
37 Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome Completed NCT00001453
38 Cognition, Steroids, and Imaging in Cushings Disease Completed NCT00081341
39 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089
40 Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Recruiting NCT01382420
41 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
42 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
43 Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome Recruiting NCT01246739
44 Study of Adrenal Gland Tumors Recruiting NCT00005927
45 Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Recruiting NCT03174847
46 Renal Sympathetic Denervation From The Adventitia on Hypertension Recruiting NCT02642445
47 Transsphenoidal Extent of Resection Study Recruiting NCT02357498
48 Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Recruiting NCT02574793
49 Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Recruiting NCT02362308
50 An Investigation of Pituitary Tumors and Related Hypothalmic Disorders Recruiting NCT00001595

Search NIH Clinical Center for Adrenal Adenoma

Genetic Tests for Adrenal Adenoma

Anatomical Context for Adrenal Adenoma

MalaCards organs/tissues related to Adrenal Adenoma:

39
Adrenal Gland, Testes, Pituitary, Kidney, Ovary, Lung, Liver

Publications for Adrenal Adenoma

Articles related to Adrenal Adenoma:

(show top 50) (show all 324)
id Title Authors Year
1
Adrenal Adenoma and Pheochromocytoma: Comparison of Multidetector CT Venous Enhancement Levels and Washout Characteristics. ( 26978001 )
2016
2
Cellular pathophysiology of an adrenal adenoma-associated mutant of the plasma membrane Ca(2+)-ATPase ATP2B3. ( 27035656 )
2016
3
Characterization of Adrenal Adenoma by Gaussian Model-Based Algorithm. ( 27020253 )
2016
4
Increased 3I^-hydroxysteroid dehydrogenase 2 and 17I+-hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. ( 26893641 )
2016
5
ADC histogram analysis for adrenal tumor histogram analysis of apparent diffusion coefficient in differentiating adrenal adenoma from pheochromocytoma. ( 27571307 )
2016
6
Comparison of Quantitative MRI and CT Washout Analysis for Differentiation of Adrenal Pheochromocytoma From Adrenal Adenoma. ( 27011100 )
2016
7
Robotic-assisted laparoscopic adrenalectomy for an adrenal adenoma. ( 26425459 )
2015
8
Black adrenal adenoma causing Cushing's syndrome: 40 years ago and today. ( 26088906 )
2015
9
cAMP signaling in cortisol-producing adrenal adenoma. ( 26139209 )
2015
10
Rare anaphylaxis and functioning adrenal adenoma. ( 25583253 )
2015
11
A functioning adrenal adenoma and pheochromocytoma in the same adrenal gland: two discrete adrenal incidentalomas. ( 25589844 )
2015
12
Bilateral Adrenal Adenoma Presented As Multiple Metatarsal And Phalangeal Fractures. ( 27299107 )
2015
13
The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma. ( 26904704 )
2015
14
Poor head growth as a presenting sign of a cortisol-secreting adrenal adenoma in a 2-year-old boy. ( 25575422 )
2015
15
Gallium-68 PSMA uptake in adrenal adenoma. ( 26394552 )
2015
16
CT sensitivity for adrenal adenoma according to lesion size. ( 26254908 )
2015
17
Characterization of lipid-poor adrenal adenoma: chemical-shift MRI and washout CT. ( 24758658 )
2014
18
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]. ( 25069672 )
2014
19
Spontaneous rupture of an adrenal adenoma managed by laparoscopic adrenalectomy: a case report. ( 24701740 )
2014
20
Effectiveness of partial adrenalectomy for concomitant hypertension in patients with nonfunctional adrenal adenoma. ( 25305227 )
2014
21
Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas. ( 24179102 )
2014
22
Aldosterone- and cortisol-co-producing adrenal adenoma without clinical features of Cushing syndrome. ( 25228847 )
2014
23
CT sensitivities for large (a8Y3A cm) adrenal adenoma and cortical carcinoma. ( 25060750 )
2014
24
Posterior gastric diverticulum mimicking adrenal adenoma on imaging. ( 25535229 )
2014
25
Periodic drop thumb, hypokalemia and adrenal adenoma. ( 23899956 )
2014
26
Spironolactone interference in the immunoassay of androstenedione in a patient with a cortisol secreting adrenal adenoma. ( 24612380 )
2014
27
Two rare cases of familial (mother and daughter) adrenocorticotropic hormone-independent Cushing's syndrome due to adrenal adenoma, as well as the asynchronous development of another contralateral adrenal adenoma in the mother. ( 24785891 )
2014
28
Imaging and management of a small cell lung cancer metastasis/adrenal adenoma collision tumor: a case report and review of the literature. ( 24571800 )
2014
29
Open-angle glaucoma secondary to Cushing syndrome related to an adrenal adenoma: Case report. ( 25264153 )
2014
30
A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. ( 24931108 )
2014
31
Endogenous Cushing's Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma. ( 23533838 )
2013
32
Giant non-functional adrenal adenoma: A case report. ( 23255953 )
2013
33
Reversibility of myocardial hypertrophy 8 years after adrenal adenoma excision and drugs and alcohol addiction withdrawal. ( 23674558 )
2013
34
Dual-energy CT: clinical application in differentiating an adrenal adenoma from a metastasis. ( 23969261 )
2013
35
Can established CT attenuation and washout criteria for adrenal adenoma accurately exclude pheochromocytoma? ( 23789665 )
2013
36
Markedly increased 18F-FDG uptake in a nonfunctioning adrenal adenoma mimicking malignancy. ( 23486332 )
2013
37
Adrenal adenoma and metastasis from clear cell renal cell carcinoma: can they be differentiated using standard MR techniques? ( 24252816 )
2013
38
Dysplastic extramedullary haematopoeisis with ringed sideroblasts mimicking adrenal adenoma. ( 23944958 )
2013
39
Cushing syndrome in pregnancy secondary to adrenal adenoma. ( 24396819 )
2013
40
Pure androgen-secreting adrenal adenoma associated with resistant hypertension. ( 23819074 )
2013
41
Percutaneous ablation of functioning adrenal adenoma: a report on 11 cases and a review of the literature. ( 23589076 )
2013
42
Differentiation of adrenal tumors in patients with hepatocellular carcinoma: adrenal adenoma versus metastasis. ( 23478006 )
2013
43
A case of cortisol producing adrenal adenoma associated with a latent aldosteronoma: usefulness of the ACTH loading test for the detection of covert aldosteronism in overt Cushing syndrome. ( 22333376 )
2012
44
Isolated Cushing's syndrome in early infancy due to left adrenal adenoma: an unusual aetiology. ( 22985617 )
2012
45
The washout rate on the delayed CT image as a diagnostic tool for adrenal adenoma verified by pathology: a multicenter study. ( 22798018 )
2012
46
Laparoscope resection of ectopic corticosteroid-secreting adrenal adenoma. ( 22635081 )
2012
47
KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas. ( 22863749 )
2012
48
Coexistence of Cushing syndrome from functional adrenal adenoma and Addison disease from immune-mediated adrenalitis. ( 22707647 )
2012
49
Black adrenal adenoma: distinction from PPNAD. ( 22761223 )
2012
50
Cushing's syndrome during pregnancy secondary to adrenal adenoma. ( 22267384 )
2012

Variations for Adrenal Adenoma

Cosmic variations for Adrenal Adenoma:

9 (show top 50) (show all 56)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM43678 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 17
2 COSM45444 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 17
3 COSM43555 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 17
4 COSM225014 RB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1960G>A p.V654M 17
5 COSM26708 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.892-1G>A p.? 17
6 COSM26707 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.664A>G p.K222E 17
7 COSM4167506 PRKACA adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.617T>G p.L206R 17
8 COSM584 NRAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.182A>G p.Q61R 17
9 COSM23025 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1654A>T p.T552S 17
10 COSM22568 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.325G>T p.E109* 17
11 COSM1684717 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>A p.G151R 17
12 COSM1684718 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.503T>G p.L168R 17
13 COSM1684720 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>C p.G151R 17
14 COSM1717390 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.433G>C p.E145Q 17
15 COSM4745631 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.737A>G p.E246G 17
16 COSM1684719 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.472A>G p.T158A 17
17 COSM4745630 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.343C>T p.R115W 17
18 COSM5546565 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.439G>C p.E147Q 17
19 COSM1732665 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.376T>C p.W126R 17
20 COSM27895 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.602G>A p.R201H 17
21 COSM27887 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>T p.R201C 17
22 COSM4962873 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.679C>G p.Q227E 17
23 COSM27899 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>A p.R201S 17
24 COSM5667 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>T p.S45F 17
25 COSM5663 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.133T>C p.S45P 17
26 COSM5692 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>A p.S45Y 17
27 COSM17661 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.130C>G p.P44A 17
28 COSM1423013 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.137T>C p.L46P 17
29 COSM5679 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.110C>G p.S37C 17
30 COSM5681 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.95A>G p.D32G 17
31 COSM5664 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.121A>G p.T41A 17
32 COSM5689 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>G p.S45C 17
33 COSM2780796 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2015C>T p.S672L 17
34 COSM4745615 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2996T>A p.V999D 17
35 COSM1738073 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1207G>C p.G403R 17
36 COSM1717733 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2310C>G p.I770M 17
37 COSM5546568 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2242G>A p.V748I 17
38 COSM4745616 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3003G>C p.K1001N 17
39 COSM5347155 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.4117G>A p.V1373M 17
40 COSM4745618 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3053C>T p.A1018V 17
41 COSM1738070 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2299T>C p.F767L 17
42 COSM1717766 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.4112C>G p.P1371R 17
43 COSM4745611 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2024T>C p.L675P 17
44 COSM5347154 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1201G>C p.V401L 17
45 COSM1738071 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3029G>A p.R1010H 17
46 COSM1717762 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.776T>A p.V259D 17
47 COSM4745619 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3511G>T p.V1171F 17
48 COSM1738072 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2301C>G p.F767L 17
49 COSM4745620 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3515T>A p.I1172N 17
50 COSM4745614 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2308A>T p.I770F 17

Expression for Adrenal Adenoma

Search GEO for disease gene expression data for Adrenal Adenoma.

Pathways for Adrenal Adenoma

Pathways related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
2
Show member pathways
12.16 CYP11A1 CYP11B2 CYP21A2 MC2R
3 11.83 CRH GIPR MC2R POMC
4
Show member pathways
11.64 CYP11A1 MC2R POMC
5 11.6 CRH CYP11A1 CYP11B1 CYP21A2 POMC SULT2A1
6
Show member pathways
11.31 CYP11B1 CYP17A1 SULT2A1
7
Show member pathways
11.24 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
8
Show member pathways
11.11 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
9 10.97 CYP11A1 HSD11B1
10
Show member pathways
10.88 CYP11B1 CYP11B2 CYP17A1 CYP21A2
11 10.28 CRH POMC

GO Terms for Adrenal Adenoma

Cellular components related to Adrenal Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial membrane GO:0031966 8.8 CYP11A1 CYP11B1 CYP11B2

Biological processes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.91 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 lipid metabolic process GO:0006629 9.89 CYP11A1 CYP11B1 CYP11B2 HSD11B1 SULT2A1
3 regulation of blood pressure GO:0008217 9.69 CYP11B1 POMC REN
4 steroid biosynthetic process GO:0006694 9.65 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
5 positive regulation of cAMP biosynthetic process GO:0030819 9.63 CRH GIPR MC2R
6 sterol metabolic process GO:0016125 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
7 response to immobilization stress GO:0035902 9.54 CRH REN
8 cellular response to potassium ion GO:0035865 9.52 CYP11B1 CYP11B2
9 C21-steroid hormone biosynthetic process GO:0006700 9.5 CYP11A1 CYP11B1 CYP11B2
10 mineralocorticoid biosynthetic process GO:0006705 9.48 CYP11B2 CYP21A2
11 aldosterone biosynthetic process GO:0032342 9.4 CYP11B1 CYP11B2
12 cortisol biosynthetic process GO:0034651 9.37 CYP11B1 CYP11B2
13 glucocorticoid biosynthetic process GO:0006704 9.35 CRH CYP11B1 CYP17A1 CYP21A2 HSD11B1
14 steroid metabolic process GO:0008202 9.23 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Molecular functions related to Adrenal Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 iron ion binding GO:0005506 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
3 steroid hydroxylase activity GO:0008395 9.4 CYP11B2 CYP21A2
4 corticosterone 18-monooxygenase activity GO:0047783 9.37 CYP11B1 CYP11B2
5 heme binding GO:0020037 9.35 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
6 steroid 11-beta-monooxygenase activity GO:0004507 9.32 CYP11B1 CYP11B2
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.02 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Sources for Adrenal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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