MCID: ADR008
MIFTS: 48

Adrenal Adenoma malady

Genetic diseases, Rare diseases, Endocrine diseases, Cancer diseases categories

Aliases & Classifications for Adrenal Adenoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Adrenal Adenoma, Aliases & Descriptions:

Name: Adrenal Adenoma 9 41 11 43
Adrenal Incidentaloma 41 47 60
Paroxysmal Extreme Pain Disorder 41 60
Adenoma of the Adrenal Gland 9 41
 
Adrenal Cortical Adenoma 41 60
Adrenocortical Adenoma 41
Familial Rectal Pain 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

47
adrenal incidentaloma:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Disease Ontology9 DOID:656
Orphanet47 463
MESH via Orphanet34 C538238
ICD10 via Orphanet26 D35.0
UMLS via Orphanet61 C2609247

Summaries for Adrenal Adenoma

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NIH Rare Diseases:41 Adenomas of the adrenal gland are non-cancerous (benign) tumors on the adrenal gland. most do not cause any signs or symptoms and rarely require treatment. however, some may become "active" or "functioning" which means they produce hormones, often in excess of what the adrenal glands typically produce. high levels of these hormones can lead to complications, including primary aldosteronism, cushing's syndrome and other medical conditions. functioning adrenal adenomas may be treated with surgery and/or medications. last updated: 11/24/2014

MalaCards based summary: Adrenal Adenoma, also known as adrenal incidentaloma, is related to cushing's syndrome and conn's syndrome. An important gene associated with Adrenal Adenoma is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Corticotropin-releasing hormone and Estrone metabolism. The compounds 19-Hydroxydeoxycorticosterone and 19-oic-deoxycorticosterone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Disease Ontology:9 An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.

Wikipedia:63 A adrenal adenoma is a benign tumor of the glandular type (adenoma) in the adrenal gland. While some... more...

Related Diseases for Adrenal Adenoma

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Diseases related to Adrenal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome31.2CYP11B2, CYP11B1, GIPR
2conn's syndrome30.7CYP11B1, CYP11B2
3adenoma30.6MEN1, GIPR, CYP11A1, CYP17A1, CYP11B1, CYP11B2
4adrenocortical carcinoma30.5CYP11B1, CYP11B2
5hypokalemia30.3CYP11B2, CYP17A1
6hyperandrogenism30.2CYP11A1, CYP17A1
7hyperaldosteronism30.1CYP17A1, MEN1, CYP11B1, CYP11B2
8leydig cell tumor30.0CYP17A1, CYP11A1
9congenital adrenal hyperplasia29.5CYP11B2, CYP11B1, CYP17A1, CYP11A1
10adrenal cortical adenoma29.2CYP17A1, CYP11B1, MEN1, CYP11A1, GIPR
11paroxysmal extreme pain disorder10.6
12pheochromocytoma10.4
13erythromelalgia10.4
14neuronitis10.4
15pain disorder10.4
16adrenal cortical carcinoma10.3
17hepatitis10.3
18ganglioneuroma10.3
19amenorrhea10.3
20extramedullary plasmacytoma10.3
21plasmacytoma10.3
22clear cell adenoma10.3
23renal cell carcinoma10.3
24multiple endocrine neoplasia10.3
25multiple endocrine neoplasia 110.2
26primary pigmented nodular adrenocortical disease10.2
27headache10.2
28hemangioma10.2
29adenomatoid tumor10.2
30pancreatitis10.2
31carney triad10.2
32glucagonoma10.2
33beckwith-wiedemann syndrome10.2
34hyperaldosteronism, familial, type ii10.2
35lung cancer10.2
36adenocarcinoma10.2
37malignant hypertension10.2
38precocious puberty10.2
39inflammatory myofibroblastic tumor10.2
40paraganglioma10.2
41thyroiditis10.2
42virilizing ovarian tumor10.2
43teratoma10.2
44reflex epilepsy10.1
45gastrointestinal stromal tumor10.1
46breast cancer10.1
47glucocorticoid resistance10.1
48adenomatous polyposis coli10.1
49autoimmune thyroiditis10.1
50papillary carcinoma10.1

Graphical network of the top 20 diseases related to Adrenal Adenoma:



Diseases related to adrenal adenoma

Symptoms for Adrenal Adenoma

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Drugs & Therapeutics for Adrenal Adenoma

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Drug clinical trials:

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Search NIH Clinical Center for Adrenal Adenoma

Genetic Tests for Adrenal Adenoma

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Anatomical Context for Adrenal Adenoma

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MalaCards organs/tissues related to Adrenal Adenoma:

31
Adrenal gland, Testes, Pituitary, Kidney, Ovary, Liver, Lung, Colon, Endothelial

Animal Models for Adrenal Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Adrenal Adenoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2MEN1, CYP11A1, CYP17A1, CYP11B1
2MP:00053797.6CYP11B2, CYP11B1, CYP11A1, GIPR, MEN1
3MP:00053767.0MEN1, GIPR, CYP11A1, CYP17A1, CYP11B1, CYP11B2

Publications for Adrenal Adenoma

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Articles related to Adrenal Adenoma:

(show top 50)    (show all 306)
idTitleAuthorsYear
1
Posterior gastric diverticulum mimicking adrenal adenoma on imaging. (25535229)
2014
2
CT sensitivities for large (a8Y3A cm) adrenal adenoma and cortical carcinoma. (25060750)
2014
3
Dysplastic extramedullary haematopoeisis with ringed sideroblasts mimicking adrenal adenoma. (23944958)
2013
4
Novel report of an adrenal adenoma in a newborn. (22813810)
2012
5
KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas. (22863749)
2012
6
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883493)
2011
7
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883494)
2011
8
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways. (21249615)
2011
9
Is there an association between non-functioning adrenal adenoma and endothelial dysfunction? (20530985)
2011
10
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21848792)
2011
11
Coexisting renal artery aneurysm and adrenal adenoma in resistant hypertension. (21693375)
2011
12
Black adrenal adenoma causing preclinical Cushing's syndrome. (21319027)
2010
13
Two different adrenal adenomas causing Cushing's syndrome. (20464053)
2010
14
Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. (19289327)
2009
15
Primary aldosteronism caused by a unilateral adrenal adenoma accompanied by autonomous cortisol secretion. (17541216)
2007
16
Cytomegalovirus and BK-Virus co-infection of a clinically non-functioning adrenal adenoma: innocent bystanders or new pathogenetic agents? (16864124)
2006
17
Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management. (16001333)
2005
18
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
19
Adrenal adenoma presenting with ventricular fibrillation. (15902830)
2005
20
Adrenal adenoma and normal androgen levels in a young woman with polycystic ovaries: a case of idiopathic hirsutism? (15053246)
2004
21
Adrenal adenoma with organizing hematoma: diagnostic dilemma at MRI. (15528004)
2004
22
Myelolipomatous foci in an adrenal adenoma causing Cushing's syndrome? (12665319)
2003
23
Primary amenorrhea accompanied by adrenal adenoma: start of menarche soon after tumor resection. (12487170)
2002
24
Bilateral asynchronous adrenal adenoma in a girl with an incomplete form of Beckwith-Wiedemann syndrome. (11271390)
2001
25
Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty. (11158024)
2001
26
Cortisol-secreting adrenal adenomas express 11beta-hydroxysteroid dehydrogenase type-2 gene yet possess low 11beta-HSD2 activity. (11288760)
2001
27
Reversible suppression of the renin-aldosterone axis after unilateral adrenalectomy for adrenal adenoma. (9669438)
1998
28
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. (9647876)
1998
29
Serum levels of dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison with adrenal Cushing's syndrome and non-functional adrenal tumor. (8930526)
1996
30
Marked hypocholesterolemia in a case with adrenal adenoma--enhanced catabolism of low density lipoprotein (LDL) via the LDL receptors of tumor cells. (7829645)
1995
31
Aldosterone and testosterone producing adrenal adenoma in childhood. (7759788)
1995
32
Another case of hypocholesterolemia associated with virilizing adrenal adenoma. (7593461)
1995
33
Possible pre-Cushing's syndrome due to an adrenal adenoma incidentally discovered. (8556058)
1995
34
Steroid secretory characteristics of a virilizing adrenal adenoma in a woman. (8169562)
1994
35
The association of aldosterone-producing adrenal adenoma in a patient with autosomal dominant polycystic kidney disease. (8172219)
1994
36
Primary adrenocortical nodular dysplasia presented as adrenal adenoma by functional scintigraphy. (8462213)
1993
37
Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus. (1639957)
1992
38
Aldosterone-producing adrenal adenoma in children. (1477069)
1992
39
Combined adrenal adenoma and myelolipoma in a patient with Conn syndrome. Case report. (1293551)
1992
40
Incidentally discovered ACTH-dependent adrenal adenoma presenting as 'pre-Cushing's syndrome'. (3004094)
1986
41
Increased 17 beta-hydroxysteroid dehydrogenase activity in a masculinizing adrenal adenoma in a patient with isolated testosterone overproduction. (6244323)
1980
42
A testosterone-secreting adrenal adenoma. (618475)
1978
43
11 beta-Hydroxydehydroepiandrosterone in a case of virilizing adrenal adenoma: isolation from urine and mitochondrial conversion from dehydroepiandrosterone. (162514)
1978
44
A case of adrenal adenoma diagnosed by means of adrenal phlebography (author's transl)]. (917890)
1977
45
Localisation of adrenal adenoma with I 131-19 iodocholesterol. (912247)
1977
46
Testosterone-secreting adrenal adenoma under gonadotropin control. (4728749)
1973
47
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970
48
Biosynthesis of allo-3-beta-tetrahydrocortisol (Reichstein's substance V) by an adrenal adenoma. (4240060)
1969
49
FORMATION OF STEROID HORMONES IN THE ADRENAL ADENOMA AND ADJACENT ADRENAL TISSUE OF A PATIENT WITH PRIMARY ALDOSTERONISM. (14069579)
1963
50
Nonhormonal adrenal adenoma: a report of two cases. (13307758)
1956

Variations for Adrenal Adenoma

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Expression for genes affiliated with Adrenal Adenoma

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Search GEO for disease gene expression data for Adrenal Adenoma.

Pathways for genes affiliated with Adrenal Adenoma

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Pathways related to Adrenal Adenoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CYP11A1, CYP11B1
2
Show member pathways
Estrogen biosynthesis58
Androstenedione and testosterone biosynthesis and metabolism p.158
9.1CYP17A1, CYP11B1
39.1CYP17A1, CYP11A1
4
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
8.5CYP11B2, CYP11B1, CYP17A1
5
Show member pathways
8.0CYP11A1, CYP17A1, CYP11B1, CYP11B2
6
Show member pathways
8.0CYP11A1, CYP17A1, CYP11B1, CYP11B2
7
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
8.0CYP11B2, CYP11B1, CYP17A1, CYP11A1
8
Show member pathways
8.0CYP11A1, CYP17A1, CYP11B1, CYP11B2
9
Show member pathways
8.0CYP11A1, CYP17A1, CYP11B1, CYP11B2

Compounds for genes affiliated with Adrenal Adenoma

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Compounds related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
119-Hydroxydeoxycorticosterone249.7CYP11B1, CYP11B2
219-oic-deoxycorticosterone249.7CYP11B1, CYP11B2
319-Oxo-deoxycorticosterone249.7CYP11B1, CYP11B2
418-hydroxydeoxycorticosterone439.7CYP11B2, CYP11B1
518-oxocortisol439.7CYP11B1, CYP11B2
618-hydroxycortisol439.7CYP11B1, CYP11B2
711b-Hydroxyandrost-4-ene-3,17-dione249.7CYP11B2, CYP11B1
811b,17a,21-Trihydroxypreg-nenolone249.7CYP11B2, CYP11B1
917a,21-Dihydroxypreg-nenolone249.7CYP11B2, CYP11B1
1018-hydroxycorticosterone43 2410.6CYP11B2, CYP11B1
11Cortexolone249.6CYP11B2, CYP11B1
12deoxycorticosterone28 2410.6CYP11B2, CYP11B1
1317a,20a-Dihydroxycholesterol249.5CYP17A1, CYP11A1
14etomidate43 1210.5CYP11B1, CYP11B2
1520alpha-hydroxycholesterol43 2410.5CYP11A1, CYP17A1
16cortisol28 2410.5CYP11B2, CYP11B1
1717a-Hydroxypregnenolone249.5CYP17A1, CYP11A1
18Pregnenolone24 1210.4CYP11A1, CYP17A1
19acth 1-24439.2CYP17A1, CYP11A1
20aminopyrine439.1CYP11A1, CYP17A1
21ketoconazole43 28 24 1212.0CYP11B1, CYP17A1, CYP11A1
2211beta-Hydroxyprogesterone249.0CYP11B2, CYP11B1, CYP17A1
2311b-Hydroxyprogesterone249.0CYP11B2, CYP11B1, CYP17A1
2421-deoxycortisol43 249.9CYP17A1, CYP11B1, CYP11B2
25pcb 126438.9CYP17A1, CYP11B1, CYP11B2
2611 deoxycortisol438.9CYP17A1, CYP11B1, CYP11B2
27aldosterone28 24 1210.9CYP11B2, CYP11B1, CYP17A1
28metoclopramide43 49 1210.9CYP11B2, CYP11B1, CYP17A1
2917beta-hydroxysteroid438.9CYP11B2, CYP17A1, CYP11A1
30dhea438.9CYP11A1, CYP17A1, CYP11B2
31dbc-amp438.8CYP11A1, CYP17A1, CYP11B2
32nifedipine43 28 49 1211.7CYP11A1, CYP17A1, CYP11B2
33doca438.4CYP11A1, CYP17A1, CYP11B1, CYP11B2
3417-hydroxyprogesterone43 249.4CYP11B2, CYP11B1, CYP17A1, CYP11A1
3511beta-hydroxysteroid438.4CYP11A1, CYP17A1, CYP11B1, CYP11B2
363beta-hydroxysteroid438.4CYP11B2, CYP11B1, CYP17A1, CYP11A1
37androstenedione43 249.4CYP11B2, CYP11B1, CYP17A1, CYP11A1
38corticosterone43 59 2410.4CYP11B2, CYP11B1, CYP17A1, CYP11A1
39sterol438.4CYP11A1, CYP17A1, CYP11B2
40heme28 24 1210.4CYP11A1, CYP17A1, CYP11B1, CYP11B2
41forskolin43 49 1210.3CYP11B2, CYP11B1, CYP17A1, CYP11A1
42cyclic amp43 249.3CYP11B2, CYP11B1, CYP17A1, CYP11A1
43progesterone43 28 59 24 1212.2CYP11B2, CYP11B1, CYP17A1, CYP11A1
44testosterone43 59 24 1211.2CYP11B2, CYP11B1, CYP17A1, CYP11A1
45cholesterol43 28 24 1211.2CYP11B2, CYP11B1, CYP17A1, CYP11A1
46steroid438.1CYP11A1, CYP17A1, CYP11B1, CYP11B2
47dexamethasone43 49 28 1211.0CYP11B2, CYP11B1, CYP17A1, CYP11A1
48acth438.0CYP11B2, CYP11B1, CYP17A1, CYP11A1, GIPR
49ribonucleic acid438.0CYP11B2, CYP11B1, CYP17A1, CYP11A1, GIPR
50Water247.7CYP11B2, CYP11B1, CYP17A1, CYP11A1

GO Terms for genes affiliated with Adrenal Adenoma

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Cellular components related to Adrenal Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00057398.0CYP11A1, CYP17A1, CYP11B1, CYP11B2

Biological processes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:00323429.7CYP11B1, CYP11B2
2maternal process involved in female pregnancyGO:00601359.7CYP11A1, MEN1
3cortisol biosynthetic processGO:00346519.7CYP11B1, CYP11B2
4response to gamma radiationGO:00103329.6MEN1, CYP11A1
5mineralocorticoid biosynthetic processGO:00067059.6CYP11B2, CYP11B1
6cellular response to potassium ionGO:00358659.6CYP11B1, CYP11B2
7response to fungicideGO:00609929.4CYP17A1, CYP11A1
8dibenzo-p-dioxin metabolic processGO:00188949.4CYP17A1, CYP11A1
9biphenyl metabolic processGO:00188799.4CYP17A1, CYP11A1
10phthalate metabolic processGO:00189639.4CYP17A1, CYP11A1
11phenol-containing compound metabolic processGO:00189589.4CYP17A1, CYP11A1
12response to insecticideGO:00170859.4CYP17A1, CYP11A1
13glucocorticoid biosynthetic processGO:00067049.3CYP11B1, CYP17A1
14cellular response to hormone stimulusGO:00328709.3CYP11B1, CYP11B2
15cellular response to antibioticGO:00712369.3CYP11A1, CYP17A1
16Leydig cell differentiationGO:00333279.3CYP11A1, CYP17A1
17C21-steroid hormone biosynthetic processGO:00067009.2CYP11A1, CYP11B1, CYP11B2
18cellular response to lipopolysaccharideGO:00712229.1CYP11A1, CYP17A1
19hippocampus developmentGO:00217669.0CYP17A1, CYP11A1
20sterol metabolic processGO:00161258.3CYP11A1, CYP17A1, CYP11B1, CYP11B2
21steroid metabolic processGO:00082028.3CYP11B2, CYP11B1, CYP17A1, CYP11A1
22xenobiotic metabolic processGO:00068058.3CYP11B2, CYP11B1, CYP17A1, CYP11A1
23small molecule metabolic processGO:00442817.7CYP11A1, CYP17A1, CYP11B1, CYP11B2

Molecular functions related to Adrenal Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:00045079.3CYP11B1, CYP11B2
2heme bindingGO:00200377.9CYP11A1, CYP17A1, CYP11B1, CYP11B2
3iron ion bindingGO:00055067.7CYP11B2, CYP11B1, CYP17A1, CYP11A1

Products for genes affiliated with Adrenal Adenoma

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Sources for Adrenal Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet