MCID: ADR008
MIFTS: 51

Adrenal Adenoma

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Adrenal Adenoma

MalaCards integrated aliases for Adrenal Adenoma:

Name: Adrenal Adenoma 12 49 51 14
Adenoma of the Adrenal Gland 12 72 49
Adrenal Cortical Adenoma 49 69
Adrenal Incidentaloma 49 69
Adrenocortical Adenoma 49

Classifications:



External Ids:

Disease Ontology 12 DOID:656

Summaries for Adrenal Adenoma

NIH Rare Diseases : 49 Adenomas of the adrenal gland are non-cancerous (benign) tumors on the adrenal gland. Most do not cause any signs or symptoms and rarely require treatment. However, some may become "active" or "functioning" which means they produce hormones, often in excess of what the adrenal glands typically produce. High levels of these hormones can lead to complications, including primary aldosteronism, Cushing's syndrome and other medical conditions. Functioning adrenal adenomas may be treated with surgery and/or medications. Last updated: 11/24/2014

MalaCards based summary : Adrenal Adenoma, also known as adenoma of the adrenal gland, is related to adenoma and adrenal cortical adenoma. An important gene associated with Adrenal Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Aldosterone synthesis and secretion. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, pituitary and thyroid, and related phenotypes are Increased transferrin (TF) endocytosis and growth/size/body region

Disease Ontology : 12 An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland.

Wikipedia : 72 An adenoma (from Greek αδένας, adeno-, \"gland\" + -ώμα, -oma, \"tumor\") (/ˌædɪˈnoʊmə/; plural adenomas... more...

Related Diseases for Adrenal Adenoma

Diseases related to Adrenal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.0 CYP11B2 MEN1 POMC
2 adrenal cortical adenoma 30.1 CYP11A1 CYP11B1 CYP17A1 CYP21A2 GIPR MC2R
3 hyperandrogenism 29.9 CYP17A1 CYP21A2 POMC
4 leydig cell tumor 29.8 CYP11A1 CYP17A1 CYP21A2
5 pheochromocytoma 29.5 CRH MEN1 POMC
6 adrenal gland hyperfunction 29.2 CRH CYP21A2 GIPR POMC
7 hypoadrenocorticism, familial 28.5 CRH CYP11A1 CYP21A2 MC2R POMC
8 hypertension, essential 28.1 CYP11B1 CYP11B2 MEN1 POMC REN
9 lipoid congenital adrenal hyperplasia 27.5 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 MC2R
10 conn's syndrome 27.3 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
11 hyperaldosteronism, familial, type ii 11.1
12 acth-independent macronodular adrenal hyperplasia 11.0
13 primary pigmented nodular adrenocortical disease 11.0
14 transsexualism 10.5 CYP17A1 CYP21A2
15 cortisone reductase deficiency 10.5 CYP21A2 HSD11B1
16 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.4 CYP21A2 POMC
17 uterine corpus endometrial carcinoma 10.3 CYP11B1 CYP11B2
18 antley-bixler syndrome 10.3 CYP17A1 CYP21A2
19 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.3 CYP11A1 CYP17A1 CYP21A2
20 cytochrome p450 oxidoreductase deficiency 10.2 CYP17A1 CYP21A2 POMC
21 sex differentiation disease 10.2 CYP17A1 CYP21A2 POMC
22 glucocorticoid deficiency 1 10.2 MC2R POMC
23 hypothalamic disease 10.2 CRH POMC
24 acth deficiency, isolated 10.2 CRH POMC
25 pituitary carcinoma 10.1 CRH POMC
26 nelson syndrome 10.1 CRH POMC
27 sheehan syndrome 10.1 CRH POMC
28 hypoadrenalism 10.1 CRH POMC
29 acth-secreting pituitary adenoma 10.1 CRH POMC
30 fasting hypoglycemia 10.1 CRH POMC
31 olivopontocerebellar atrophy 10.1 ATP2B3 CRH
32 achalasia-addisonianism-alacrima syndrome 10.1 MC2R POMC
33 polycystic ovary syndrome 10.0 CYP11A1 CYP17A1 CYP21A2 HSD11B1
34 withdrawal disorder 10.0 CRH POMC
35 familial hyperaldosteronism 10.0 CYP11B1 CYP11B2 MEN1
36 testicular leydig cell tumor 10.0 CYP11A1 CYP17A1 CYP21A2 POMC
37 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.0 CYP11A1 CYP17A1 CYP21A2 POMC
38 functioning pituitary adenoma 10.0 MEN1 POMC
39 persistent fetal circulation syndrome 9.9 CRH POMC
40 suprasellar meningioma 9.9 POMC REN
41 inappropriate adh syndrome 9.9 POMC REN
42 amenorrhea 9.9
43 postpartum depression 9.9 CRH HSD11B1
44 aldosterone-producing adenoma 9.9 CYP11B2 CYP21A2 REN
45 multiple endocrine neoplasia, type i 9.9
46 renal cell carcinoma, nonpapillary 9.9
47 hypokalemia 9.9
48 multiple endocrine neoplasia 9.9
49 pseudohyperkalemia, familial, 2, due to red cell leak 9.8 CYP11B2 CYP21A2 REN
50 lentigines 9.8 MEN1 POMC

Graphical network of the top 20 diseases related to Adrenal Adenoma:



Diseases related to Adrenal Adenoma

Symptoms & Phenotypes for Adrenal Adenoma

GenomeRNAi Phenotypes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased transferrin (TF) endocytosis GR00363-A 9.32 CRH CYP11A1 CYP11B1 CYP11B2 CYP21A2 GIPR

MGI Mouse Phenotypes related to Adrenal Adenoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.07 CYP11B1 MC2R CYP11B2 CRH CYP17A1 CYP11A1
2 behavior/neurological MP:0005386 10.06 CYP11B1 MC2R CRH CYP17A1 CYP11A1 HSD11B1
3 endocrine/exocrine gland MP:0005379 10.06 CYP11B1 MC2R CYP11B2 CRH GIPR CYP11A1
4 homeostasis/metabolism MP:0005376 10.06 CYP11B1 MC2R CYP11B2 CRH CYP17A1 GIPR
5 cardiovascular system MP:0005385 10.03 CYP11B1 MC2R CYP11B2 CYP11A1 HSD11B1 REN
6 adipose tissue MP:0005375 9.95 MC2R CYP11B2 CRH CYP17A1 HSD11B1 POMC
7 immune system MP:0005387 9.86 HSD11B1 MC2R CYP11B2 CRH CYP11A1 REN
8 liver/biliary system MP:0005370 9.63 CYP11B2 CRH CYP11A1 HSD11B1 MEN1 POMC
9 nervous system MP:0003631 9.56 HSD11B1 MC2R CYP11B2 CRH CYP11A1 REN
10 renal/urinary system MP:0005367 9.1 CYP11B1 CYP11B2 CRH CYP17A1 REN POMC

Drugs & Therapeutics for Adrenal Adenoma

Drugs for Adrenal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
2 Racepinephrine Approved Phase 4,Phase 3,Phase 2 329-65-7
3 Respiratory System Agents Phase 4,Phase 2,Phase 3
4 Adrenergic Agents Phase 4,Phase 2,Phase 3
5 Adrenergic Agonists Phase 4,Phase 2,Phase 3
6 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3
7 Mydriatics Phase 4,Phase 2,Phase 3
8 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 3
9 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
10 Vasoconstrictor Agents Phase 4,Phase 2,Phase 3
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
12 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3
13 Epinephryl borate Phase 4,Phase 3,Phase 2
14 Autonomic Agents Phase 4,Phase 3,Phase 2
15 Bronchodilator Agents Phase 4,Phase 2,Phase 3
16
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
17
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
18
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2 50-23-7 657311 5754
19
Etomidate Approved Phase 2, Phase 3 33125-97-2 667484 36339
20 beta-endorphin Phase 3
21 Dexamethasone acetate Phase 3,Phase 2 1177-87-3
22 glucocorticoids Phase 3,Phase 2
23
protease inhibitors Phase 3,Phase 2
24 Adrenocorticotropic Hormone Phase 3,Phase 2
25 Gastrointestinal Agents Phase 3,Phase 2
26 Contraceptive Agents Phase 3
27 Contraceptives, Oral Phase 3
28 Contraceptives, Postcoital Phase 3
29 Cortisol succinate Phase 3,Phase 2
30 HIV Protease Inhibitors Phase 3,Phase 2
31 Hormone Antagonists Phase 3,Phase 2
32 Hormones Phase 3,Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
34 Hydrocortisone 17-butyrate 21-propionate Phase 3,Phase 2
35 Hydrocortisone acetate Phase 3,Phase 2
36 Antiemetics Phase 3,Phase 2
37 Anti-Inflammatory Agents Phase 3,Phase 2
38 Antineoplastic Agents, Hormonal Phase 3,Phase 2
39 Luteolytic Agents Phase 3
40 Melanocyte-Stimulating Hormones Phase 3
41 BB 1101 Phase 3,Phase 2
42 Central Nervous System Depressants Phase 2, Phase 3
43 Fluorodeoxyglucose F18 Phase 2, Phase 3
44 Anesthetics Phase 2, Phase 3
45 Anesthetics, General Phase 2, Phase 3
46 Anesthetics, Intravenous Phase 2, Phase 3
47 Hypnotics and Sedatives Phase 2, Phase 3
48
Ethanol Approved 64-17-5 702
49
Menthol Approved 2216-51-5 16666
50
Prazosin Approved 19216-56-9 4893

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronism Unknown status NCT02127840 Phase 4 Synacthen infusion during adrenal venous sampling
2 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
3 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
4 Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? Recruiting NCT01504555 Phase 3
5 Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia Not yet recruiting NCT02010957 Phase 2, Phase 3
6 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
7 Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism Completed NCT02001051 Phase 2
8 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Recruiting NCT02468193 Phase 2 Osilodrostat
9 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Recruiting NCT02804750 Phase 2 CORT125134
10 Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma Completed NCT00768365
11 Comparison Between Posterior Retroperitoneoscopic Adrenalectomy and Laparoscopic Adrenalectomy Completed NCT01676025
12 Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas Recruiting NCT02364089 Standardized medical treatment of hypertension by SAHR
13 Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma Recruiting NCT01382420
14 Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism Recruiting NCT02756754
15 Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield Recruiting NCT02324647
16 Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue Recruiting NCT01949714
17 Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome Recruiting NCT01246739
18 Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome Recruiting NCT03211624
19 Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks Recruiting NCT03374215
20 Study of Adrenal Gland Tumors Recruiting NCT00005927
21 Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Active, not recruiting NCT02030587
22 Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas Not yet recruiting NCT03405025
23 A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia Terminated NCT00796783 Cushing's syndrome confirmation

Search NIH Clinical Center for Adrenal Adenoma

Genetic Tests for Adrenal Adenoma

Anatomical Context for Adrenal Adenoma

MalaCards organs/tissues related to Adrenal Adenoma:

38
Adrenal Gland, Pituitary, Thyroid, Prostate, Testes, Ovary, Liver

Publications for Adrenal Adenoma

Articles related to Adrenal Adenoma:

(show top 50) (show all 330)
# Title Authors Year
1
PENTRAXIN 3 AS A NEW CARDIOVASCULAR MARKER IN ADRENAL ADENOMAS. ( 28332877 )
2017
2
Diagnostic accuracy of virtual non-contrast enhanced dual-energy CT for diagnosis of adrenal adenoma: A systematic review and meta-analysis. ( 28289937 )
2017
3
Effects of Mifepristone on Nonalcoholic Fatty Liver Disease in a Patient with a Cortisol-Secreting Adrenal Adenoma. ( 29348947 )
2017
4
PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations. ( 27871112 )
2017
5
Reninoma coexisting with adrenal adenoma during pregnancy: A case report. ( 28521424 )
2017
6
An exceedingly rare adrenal collision tumor: adrenal adenoma-metastatic breast cancer-myelolipoma. ( 29046752 )
2017
7
Adrenal Adenoma and Pheochromocytoma: Comparison of Multidetector CT Venous Enhancement Levels and Washout Characteristics. ( 26978001 )
2016
8
Comparison of Quantitative MRI and CT Washout Analysis for Differentiation of Adrenal Pheochromocytoma From Adrenal Adenoma. ( 27011100 )
2016
9
Cellular pathophysiology of an adrenal adenoma-associated mutant of the plasma membrane Ca(2+)-ATPase ATP2B3. ( 27035656 )
2016
10
ADC histogram analysis for adrenal tumor histogram analysis of apparent diffusion coefficient in differentiating adrenal adenoma from pheochromocytoma. ( 27571307 )
2016
11
Increased 3I^-hydroxysteroid dehydrogenase 2 and 17I+-hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report. ( 26893641 )
2016
12
Characterization of Adrenal Adenoma by Gaussian Model-Based Algorithm. ( 27020253 )
2016
13
Black adrenal adenoma causing Cushing's syndrome: 40 years ago and today. ( 26088906 )
2015
14
Poor head growth as a presenting sign of a cortisol-secreting adrenal adenoma in a 2-year-old boy. ( 25575422 )
2015
15
A functioning adrenal adenoma and pheochromocytoma in the same adrenal gland: two discrete adrenal incidentalomas. ( 25589844 )
2015
16
cAMP signaling in cortisol-producing adrenal adenoma. ( 26139209 )
2015
17
Rare anaphylaxis and functioning adrenal adenoma. ( 25583253 )
2015
18
Gallium-68 PSMA uptake in adrenal adenoma. ( 26394552 )
2015
19
The Importance of Exclusion of Obstructive Sleep Apnea During Screening for Adrenal Adenoma and Diagnosis of Pheochromocytoma. ( 26904704 )
2015
20
CT sensitivity for adrenal adenoma according to lesion size. ( 26254908 )
2015
21
Robotic-assisted laparoscopic adrenalectomy for an adrenal adenoma. ( 26425459 )
2015
22
Bilateral Adrenal Adenoma Presented As Multiple Metatarsal And Phalangeal Fractures. ( 27299107 )
2015
23
Open-angle glaucoma secondary to Cushing syndrome related to an adrenal adenoma: Case report. ( 25264153 )
2014
24
Spironolactone interference in the immunoassay of androstenedione in a patient with a cortisol secreting adrenal adenoma. ( 24612380 )
2014
25
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]. ( 25069672 )
2014
26
Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas. ( 24179102 )
2014
27
Imaging and management of a small cell lung cancer metastasis/adrenal adenoma collision tumor: a case report and review of the literature. ( 24571800 )
2014
28
Posterior gastric diverticulum mimicking adrenal adenoma on imaging. ( 25535229 )
2014
29
Two rare cases of familial (mother and daughter) adrenocorticotropic hormone-independent Cushing's syndrome due to adrenal adenoma, as well as the asynchronous development of another contralateral adrenal adenoma in the mother. ( 24785891 )
2014
30
Characterization of lipid-poor adrenal adenoma: chemical-shift MRI and washout CT. ( 24758658 )
2014
31
Spontaneous rupture of an adrenal adenoma managed by laparoscopic adrenalectomy: a case report. ( 24701740 )
2014
32
A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. ( 24931108 )
2014
33
Effectiveness of partial adrenalectomy for concomitant hypertension in patients with nonfunctional adrenal adenoma. ( 25305227 )
2014
34
CT sensitivities for large (a8Y3A cm) adrenal adenoma and cortical carcinoma. ( 25060750 )
2014
35
Periodic drop thumb, hypokalemia and adrenal adenoma. ( 23899956 )
2014
36
Aldosterone- and cortisol-co-producing adrenal adenoma without clinical features of Cushing syndrome. ( 25228847 )
2014
37
Differentiation of adrenal tumors in patients with hepatocellular carcinoma: adrenal adenoma versus metastasis. ( 23478006 )
2013
38
Cushing syndrome in pregnancy secondary to adrenal adenoma. ( 24396819 )
2013
39
Pure androgen-secreting adrenal adenoma associated with resistant hypertension. ( 23819074 )
2013
40
Dysplastic extramedullary haematopoeisis with ringed sideroblasts mimicking adrenal adenoma. ( 23944958 )
2013
41
Giant non-functional adrenal adenoma: A case report. ( 23255953 )
2013
42
Markedly increased 18F-FDG uptake in a nonfunctioning adrenal adenoma mimicking malignancy. ( 23486332 )
2013
43
Dual-energy CT: clinical application in differentiating an adrenal adenoma from a metastasis. ( 23969261 )
2013
44
Reversibility of myocardial hypertrophy 8 years after adrenal adenoma excision and drugs and alcohol addiction withdrawal. ( 23674558 )
2013
45
Adrenal adenoma and metastasis from clear cell renal cell carcinoma: can they be differentiated using standard MR techniques? ( 24252816 )
2013
46
Can established CT attenuation and washout criteria for adrenal adenoma accurately exclude pheochromocytoma? ( 23789665 )
2013
47
Percutaneous ablation of functioning adrenal adenoma: a report on 11 cases and a review of the literature. ( 23589076 )
2013
48
Endogenous Cushing's Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma. ( 23533838 )
2013
49
Long-term cognitive impairments and attentional deficits in patients with Cushing's disease and cortisol-producing adrenal adenoma in remission. ( 22761462 )
2012
50
Isolated Cushing's syndrome in early infancy due to left adrenal adenoma: an unusual aetiology. ( 22985617 )
2012

Variations for Adrenal Adenoma

ClinVar genetic disease variations for Adrenal Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MEN1 NM_000244.3(MEN1): c.1669A> T (p.Thr557Ser) single nucleotide variant Pathogenic rs121913035 GRCh37 Chromosome 11, 64571985: 64571985

Cosmic variations for Adrenal Adenoma:

9 (show top 50) (show all 62)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM43678 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.305C>T p.T102I 21
2 COSM45444 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.587G>T p.R196L 21
3 COSM43555 TP53 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.736A>G p.M246V 21
4 COSM225014 RB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1960G>A p.V654M 21
5 COSM26707 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.664A>G p.K222E 21
6 COSM26708 PRKAR1A adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.892-1G>A p.? 21
7 COSM4167506 PRKACA adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.617T>G p.L206R 21
8 COSM5885970 PRKACA adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.262C>G p.H88D 21
9 COSM584 NRAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.182A>G p.Q61R 21
10 COSM23025 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1654A>T p.T552S 21
11 COSM22568 MEN1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.325G>T p.E109* 21
12 COSM1684718 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.503T>G p.L168R 21
13 COSM1684720 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>C p.G151R 21
14 COSM1684717 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.451G>A p.G151R 21
15 COSM4745631 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.737A>G p.E246G 21
16 COSM1717390 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.433G>C p.E145Q 21
17 COSM4745630 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.343C>T p.R115W 21
18 COSM5546565 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.439G>C p.E147Q 21
19 COSM1684719 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.472A>G p.T158A 21
20 COSM5990170 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.461T>G p.F154C 21
21 COSM1732665 KCNJ5 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.376T>C p.W126R 21
22 COSM27887 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>T p.R201C 21
23 COSM27895 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.602G>A p.R201H 21
24 COSM4962873 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.679C>G p.Q227E 21
25 COSM27899 GNAS adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.601C>A p.R201S 21
26 COSM5663 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.133T>C p.S45P 21
27 COSM5667 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>T p.S45F 21
28 COSM1423013 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.137T>C p.L46P 21
29 COSM17661 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.130C>G p.P44A 21
30 COSM5988492 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.101G>C p.G34A 21
31 COSM5681 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.95A>G p.D32G 21
32 COSM5677 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.98C>G p.S33C 21
33 COSM5664 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.121A>G p.T41A 21
34 COSM5686 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.100G>A p.G34R 21
35 COSM5692 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>A p.S45Y 21
36 COSM5689 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.134C>G p.S45C 21
37 COSM5678 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.107A>C p.H36P 21
38 COSM5679 CTNNB1 adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.110C>G p.S37C 21
39 COSM2780796 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2015C>T p.S672L 21
40 COSM4745616 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3003G>C p.K1001N 21
41 COSM1717733 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2310C>G p.I770M 21
42 COSM4745615 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2996T>A p.V999D 21
43 COSM4745620 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3515T>A p.I1172N 21
44 COSM1738073 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.1207G>C p.G403R 21
45 COSM1738070 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2299T>C p.F767L 21
46 COSM4745618 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.3053C>T p.A1018V 21
47 COSM1738072 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2301C>G p.F767L 21
48 COSM4745611 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2024T>C p.L675P 21
49 COSM1717766 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.4112C>G p.P1371R 21
50 COSM4745614 CACNA1D adrenal gland,adrenal gland,adrenal cortical adenoma,NS c.2308A>T p.I770F 21

Expression for Adrenal Adenoma

Search GEO for disease gene expression data for Adrenal Adenoma.

Pathways for Adrenal Adenoma

Pathways related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 POMC
2
Show member pathways
12.43 ATP2B3 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
3
Show member pathways
11.97 ATP2B3 GIPR MC2R
4 11.83 CRH GIPR MC2R POMC
5 11.69 CRH CYP11A1 CYP11B1 CYP21A2 POMC
6
Show member pathways
11.62 CYP11A1 MC2R POMC
7
Show member pathways
11.25 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
8
Show member pathways
11.11 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
9 10.95 CYP11A1 HSD11B1
10
Show member pathways
10.9 CYP11B1 CYP11B2 CYP17A1 CYP21A2
11 10.25 CRH POMC

GO Terms for Adrenal Adenoma

Cellular components related to Adrenal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial membrane GO:0031966 8.8 CYP11A1 CYP11B1 CYP11B2

Biological processes related to Adrenal Adenoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.85 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 lipid metabolic process GO:0006629 9.84 CYP11A1 CYP11B1 CYP11B2 HSD11B1
3 regulation of blood pressure GO:0008217 9.67 CYP11B1 POMC REN
4 steroid biosynthetic process GO:0006694 9.65 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
5 positive regulation of cAMP biosynthetic process GO:0030819 9.63 CRH GIPR MC2R
6 sterol metabolic process GO:0016125 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
7 response to immobilization stress GO:0035902 9.52 CRH REN
8 cellular response to potassium ion GO:0035865 9.51 CYP11B1 CYP11B2
9 C21-steroid hormone biosynthetic process GO:0006700 9.5 CYP11A1 CYP11B1 CYP11B2
10 steroid metabolic process GO:0008202 9.5 CRH CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
11 mineralocorticoid biosynthetic process GO:0006705 9.48 CYP11B2 CYP21A2
12 cortisol biosynthetic process GO:0034651 9.43 CYP11B1 CYP11B2
13 aldosterone biosynthetic process GO:0032342 9.4 CYP11B1 CYP11B2
14 glucocorticoid biosynthetic process GO:0006704 9.02 CRH CYP11B1 CYP17A1 CYP21A2 HSD11B1

Molecular functions related to Adrenal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1
2 iron ion binding GO:0005506 9.55 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
3 neuropeptide hormone activity GO:0005184 9.43 CRH POMC
4 steroid hydroxylase activity GO:0008395 9.4 CYP11B2 CYP21A2
5 corticosterone 18-monooxygenase activity GO:0047783 9.37 CYP11B1 CYP11B2
6 heme binding GO:0020037 9.35 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2
7 steroid 11-beta-monooxygenase activity GO:0004507 9.32 CYP11B1 CYP11B2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.02 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP21A2

Sources for Adrenal Adenoma

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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