MCID: ADR008
MIFTS: 55

Adrenal Adenoma malady

Rare diseases, Endocrine diseases, Cancer diseases categories

Summaries for Adrenal Adenoma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 An adenoma of the adrenal gland is a non-cancerous (benign) tumor on the adrenal gland. it can develop at any age but is more common in people between the ages of 40 and 60; people over age 70 are at significantly higher risk. itĀ typically causes no complications, but in some cases, can cause severe problems. sometimes these tumors become "active" or "functioning" which means they produce hormones, often in excess of what the adrenal glands typically produce. this can have negative effects on an individual's health, potentially causingĀ primary aldosteronism, cushing's syndrome and other medical conditions. most benign adrenal tumors are non-functioning and do not need immediate treatment, but some may become functioning and require treatment including medications or surgery. last updated: 10/24/2011

MalaCards: Adrenal Adenoma, also known as adenoma of the adrenal gland, is related to adenoma and cushing's syndrome. An important gene associated with Adrenal Adenoma is MEN1 (multiple endocrine neoplasia I), and among its related pathways are Corticotropin-releasing hormone and Estrone metabolism. The compounds 19-Oxo-deoxycorticosterone and 19-oic-deoxycorticosterone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and pituitary, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Wikipedia:66 A adrenal adenoma is a benign tumor of the glandular type (adenoma) in the adrenal gland. While some... more...

Aliases & Classifications for Adrenal Adenoma

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

50
adrenal incidentaloma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

adrenal adenoma 9 44 11 46
adenoma of the adrenal gland 9 44
adrenal cortical adenoma 44 63
adrenal incidentaloma 44 50
adrenocortical adenoma 44
adenoma adrenocortical 46


External Ids:

Disease Ontology9 DOID:656
MESH via Orphanet37 C538238
ICD10 via Orphanet27 D35.0
SNOMED-CT via Orphanet60 127021009
UMLS via Orphanet64 C2609247

Related Diseases for Adrenal Adenoma

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18GeneCards, 19GeneDecks
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Diseases related to Adrenal Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.6MEN1, GIPR, CYP11A1, CYP17A1, CYP11B1, CYP11B2
2cushing's syndrome31.3CYP11B2, CYP11B1, GIPR
3hypertension30.9CYP11B2, CYP11B1, CYP17A1
4hyperaldosteronism30.6CYP17A1, MEN1, CYP11B1, CYP11B2
5conn's syndrome30.6CYP11B1, CYP11B2
6adrenocortical carcinoma30.4CYP11B1, CYP11B2
7hypokalemia30.4CYP11B2, CYP17A1
8hyperandrogenism30.2CYP11A1, CYP17A1
9congenital adrenal hyperplasia30.1CYP11B2, CYP11B1, CYP17A1, CYP11A1
10leydig cell tumor30.0CYP17A1, CYP11A1
11essential hypertension30.0CYP11B2, CYP11B1
12pheochromocytoma10.4
13ganglioneuroma10.3
14amenorrhea10.3
15extramedullary plasmacytoma10.3
16plasmacytoma10.3
17clear cell adenoma10.3
18renal cell carcinoma10.3
19multiple endocrine neoplasia10.3
20primary pigmented nodular adrenocortical disease10.2
21prolactinoma10.2
22hemangioma10.2
23hepatitis10.2
24pancreatitis10.2
25carney triad10.2
26glucagonoma10.2
27beckwith-wiedemann syndrome10.2
28adenocarcinoma10.2
29glaucoma10.2
30malignant hypertension10.2
31familial hyperaldosteronism type 210.2
32precocious puberty10.2
33adrenal adenoma, somatic10.2
34paraganglioma10.1
35thyroiditis10.1
36inflammatory myofibroblastic tumor10.1
37virilizing ovarian tumor10.1
38insulin resistance10.1
39teratoma10.1
40autoimmune thyroiditis10.1
41gastrointestinal stromal tumor10.1
42alzheimer's disease10.1
43papillary carcinoma10.1
44wermer syndrome10.1
45primary hyperparathyroidism10.1
46anhidrosis10.1
47breast cancer10.1
48ganglioneuroblastoma10.1
49oligohydramnios10.1
50prostate adenocarcinoma10.1

Graphical network of the top 20 diseases related to Adrenal Adenoma:



Diseases related to adrenal adenoma

Symptoms for Adrenal Adenoma

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Drugs & Therapeutics for Adrenal Adenoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Adrenal Adenoma

Drug clinical trials:

Search ClinicalTrials for Adrenal Adenoma

Search NIH Clinical Center for Adrenal Adenoma

Search CenterWatch for Adrenal Adenoma

Genetic Tests for Adrenal Adenoma

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Anatomical Context for Adrenal Adenoma

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34MalaCards
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MalaCards organs/tissues related to Adrenal Adenoma:

34
Adrenal gland, Testes, Pituitary, Kidney, Ovary, Liver, Colon, Lung, Endothelial

Animal Models for Adrenal Adenoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Adrenal Adenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.2MEN1, CYP11A1, CYP17A1, CYP11B1
2MP:00053797.6CYP11B2, CYP11B1, CYP11A1, GIPR, MEN1
3MP:00053767.0MEN1, GIPR, CYP11A1, CYP17A1, CYP11B1, CYP11B2

Publications for Adrenal Adenoma

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53PubMed
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Articles related to Adrenal Adenoma:

(show top 50)    (show all 293)
idTitleAuthorsYear
1
Dysplastic extramedullary haematopoeisis with ringed sideroblasts mimicking adrenal adenoma. (23944958)
2013
2
Novel report of an adrenal adenoma in a newborn. (22813810)
2012
3
KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas. (22863749)
2012
4
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883493)
2011
5
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21883494)
2011
6
Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways. (21249615)
2011
7
Is there an association between non-functioning adrenal adenoma and endothelial dysfunction? (20530985)
2011
8
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. (21848792)
2011
9
Coexisting renal artery aneurysm and adrenal adenoma in resistant hypertension. (21693375)
2011
10
Black adrenal adenoma causing preclinical Cushing's syndrome. (21319027)
2010
11
Two different adrenal adenomas causing Cushing's syndrome. (20464053)
2010
12
Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. (19289327)
2009
13
Primary aldosteronism caused by a unilateral adrenal adenoma accompanied by autonomous cortisol secretion. (17541216)
2007
14
Cytomegalovirus and BK-Virus co-infection of a clinically non-functioning adrenal adenoma: innocent bystanders or new pathogenetic agents? (16864124)
2006
15
Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management. (16001333)
2005
16
Primary hyperaldosteronism with normokalaemia secondary to an adrenal adenoma (Conn's syndrome) in a 12 year-old boy. (15751612)
2005
17
Adrenal adenoma presenting with ventricular fibrillation. (15902830)
2005
18
Adrenal adenoma and normal androgen levels in a young woman with polycystic ovaries: a case of idiopathic hirsutism? (15053246)
2004
19
Adrenal adenoma with organizing hematoma: diagnostic dilemma at MRI. (15528004)
2004
20
Myelolipomatous foci in an adrenal adenoma causing Cushing's syndrome? (12665319)
2003
21
Primary amenorrhea accompanied by adrenal adenoma: start of menarche soon after tumor resection. (12487170)
2002
22
Bilateral asynchronous adrenal adenoma in a girl with an incomplete form of Beckwith-Wiedemann syndrome. (11271390)
2001
23
Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty. (11158024)
2001
24
Cortisol-secreting adrenal adenomas express 11beta-hydroxysteroid dehydrogenase type-2 gene yet possess low 11beta-HSD2 activity. (11288760)
2001
25
Reversible suppression of the renin-aldosterone axis after unilateral adrenalectomy for adrenal adenoma. (9669438)
1998
26
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. (9647876)
1998
27
Serum levels of dehydroepiandrosterone sulfate in patients with asymptomatic cortisol producing adrenal adenoma: comparison with adrenal Cushing's syndrome and non-functional adrenal tumor. (8930526)
1996
28
Marked hypocholesterolemia in a case with adrenal adenoma--enhanced catabolism of low density lipoprotein (LDL) via the LDL receptors of tumor cells. (7829645)
1995
29
Aldosterone and testosterone producing adrenal adenoma in childhood. (7759788)
1995
30
Another case of hypocholesterolemia associated with virilizing adrenal adenoma. (7593461)
1995
31
Possible pre-Cushing's syndrome due to an adrenal adenoma incidentally discovered. (8556058)
1995
32
Exacerbation of rheumatoid arthritis after removal of adrenal adenoma in Cushing's syndrome. (7627266)
1995
33
Steroid secretory characteristics of a virilizing adrenal adenoma in a woman. (8169562)
1994
34
The association of aldosterone-producing adrenal adenoma in a patient with autosomal dominant polycystic kidney disease. (8172219)
1994
35
Primary adrenocortical nodular dysplasia presented as adrenal adenoma by functional scintigraphy. (8462213)
1993
36
Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus. (1639957)
1992
37
Aldosterone-producing adrenal adenoma in children. (1477069)
1992
38
Combined adrenal adenoma and myelolipoma in a patient with Conn syndrome. Case report. (1293551)
1992
39
Incidentally discovered ACTH-dependent adrenal adenoma presenting as 'pre-Cushing's syndrome'. (3004094)
1986
40
Urinary kallikrein excretion in patients with primary aldosteronism: differentiation of adrenal adenoma from idiopathic adrenal hyperplasia. (6375065)
1984
41
Increased 17 beta-hydroxysteroid dehydrogenase activity in a masculinizing adrenal adenoma in a patient with isolated testosterone overproduction. (6244323)
1980
42
Hypertension and aldosterone overproduction without renin suppression in Cushing's syndrome from an adrenal adenoma. (474601)
1979
43
11 beta-Hydroxydehydroepiandrosterone in a case of virilizing adrenal adenoma: isolation from urine and mitochondrial conversion from dehydroepiandrosterone. (162514)
1978
44
A case of adrenal adenoma diagnosed by means of adrenal phlebography (author's transl)]. (917890)
1977
45
Localisation of adrenal adenoma with I 131-19 iodocholesterol. (912247)
1977
46
Testosterone-secreting adrenal adenoma under gonadotropin control. (4728749)
1973
47
Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. (4319080)
1970
48
Biosynthesis of allo-3-beta-tetrahydrocortisol (Reichstein's substance V) by an adrenal adenoma. (4240060)
1969
49
FORMATION OF STEROID HORMONES IN THE ADRENAL ADENOMA AND ADJACENT ADRENAL TISSUE OF A PATIENT WITH PRIMARY ALDOSTERONISM. (14069579)
1963
50
Nonhormonal adrenal adenoma: a report of two cases. (13307758)
1956

Variations for Adrenal Adenoma

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Expression for genes affiliated with Adrenal Adenoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Adrenal Adenoma

Search GEO for disease gene expression data for Adrenal Adenoma.

Pathways for genes affiliated with Adrenal Adenoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 52PharmGKB
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Pathways related to Adrenal Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CYP11A1, CYP11B1
2
Show member pathways
Estrogen biosynthesis61
Androstenedione and testosterone biosynthesis and metabolism p.161
9.1CYP17A1, CYP11B1
39.1CYP11A1, CYP17A1
4
Show member pathways
estradiol biosynthesis II39
androgen biosynthesis39
estradiol biosynthesis I39
progesterone biosynthesis39
8.5CYP11B1, CYP11B2, CYP17A1
5
Show member pathways
8.0CYP11A1, CYP11B2, CYP11B1, CYP17A1
6
Show member pathways
8.0CYP17A1, CYP11B1, CYP11B2, CYP11A1
7
Show member pathways
8.0CYP11B2, CYP11B1, CYP17A1, CYP11A1
8
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
8.0CYP11A1, CYP17A1, CYP11B1, CYP11B2
9
Show member pathways
8.0CYP11B2, CYP11B1, CYP17A1, CYP11A1

Compounds for genes affiliated with Adrenal Adenoma

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25HMDB, 46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Adrenal Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
119-Oxo-deoxycorticosterone259.7CYP11B1, CYP11B2
219-oic-deoxycorticosterone259.7CYP11B2, CYP11B1
319-Hydroxydeoxycorticosterone259.7CYP11B2, CYP11B1
418-hydroxydeoxycorticosterone469.7CYP11B2, CYP11B1
518-hydroxycortisol469.7CYP11B2, CYP11B1
618-oxocortisol469.7CYP11B2, CYP11B1
711b-Hydroxyandrost-4-ene-3,17-dione259.7CYP11B1, CYP11B2
811b,17a,21-Trihydroxypreg-nenolone259.7CYP11B2, CYP11B1
917a,21-Dihydroxypreg-nenolone259.7CYP11B2, CYP11B1
1018-hydroxycorticosterone46 2510.7CYP11B2, CYP11B1
11deoxycorticosterone30 2510.6CYP11B2, CYP11B1
12Cortexolone259.6CYP11B2, CYP11B1
13etomidate46 1210.5CYP11B1, CYP11B2
1417a,20a-Dihydroxycholesterol259.5CYP11A1, CYP17A1
1520alpha-hydroxycholesterol46 2510.5CYP11A1, CYP17A1
16cortisol30 2510.4CYP11B1, CYP11B2
1717a-Hydroxypregnenolone259.4CYP17A1, CYP11A1
18Pregnenolone25 1210.4CYP11A1, CYP17A1
19acth 1-24469.3CYP17A1, CYP11A1
20aminopyrine469.1CYP11A1, CYP17A1
21ketoconazole46 30 25 1212.0CYP11A1, CYP17A1, CYP11B1
2211b-Hydroxyprogesterone259.0CYP11B2, CYP11B1, CYP17A1
2311beta-Hydroxyprogesterone259.0CYP17A1, CYP11B2, CYP11B1
2421-deoxycortisol46 259.9CYP11B2, CYP17A1, CYP11B1
25pcb 126468.9CYP11B2, CYP17A1, CYP11B1
2611 deoxycortisol468.9CYP11B2, CYP17A1, CYP11B1
27aldosterone30 25 1210.9CYP11B1, CYP11B2, CYP17A1
28metoclopramide46 52 1210.9CYP11B2, CYP17A1, CYP11B1
2917beta-hydroxysteroid468.9CYP11B2, CYP17A1, CYP11A1
30dhea468.9CYP17A1, CYP11B2, CYP11A1
31dbc-amp468.8CYP11A1, CYP17A1, CYP11B2
32nifedipine46 30 52 1211.7CYP11B2, CYP11A1, CYP17A1
33doca468.4CYP11B1, CYP17A1, CYP11A1, CYP11B2
3417-hydroxyprogesterone46 259.4CYP11B2, CYP11B1, CYP17A1, CYP11A1
3511beta-hydroxysteroid468.4CYP17A1, CYP11B1, CYP11B2, CYP11A1
363beta-hydroxysteroid468.4CYP17A1, CYP11B1, CYP11B2, CYP11A1
37androstenedione46 259.4CYP11B2, CYP11B1, CYP17A1, CYP11A1
38corticosterone46 62 2510.4CYP11B2, CYP11A1, CYP17A1, CYP11B1
39sterol468.4CYP11A1, CYP17A1, CYP11B2
40heme30 25 1210.4CYP11A1, CYP11B1, CYP11B2, CYP17A1
41forskolin46 52 1210.3CYP11B2, CYP11A1, CYP17A1, CYP11B1
42cyclic amp46 259.3CYP11B2, CYP11A1, CYP17A1, CYP11B1
43progesterone46 30 62 25 1212.2CYP11B2, CYP11B1, CYP17A1, CYP11A1
44testosterone46 62 25 1211.2CYP11B2, CYP11B1, CYP17A1, CYP11A1
45cholesterol46 30 25 1211.2CYP11A1, CYP11B2, CYP11B1, CYP17A1
46steroid468.1CYP11B1, CYP11B2, CYP17A1, CYP11A1
47dexamethasone46 52 30 1211.0CYP11B1, CYP11A1, CYP17A1, CYP11B2
48acth468.0GIPR, CYP11A1, CYP17A1, CYP11B1, CYP11B2
49ribonucleic acid468.0CYP11A1, CYP11B2, GIPR, CYP17A1, CYP11B1
50Water257.7CYP11A1, CYP17A1, CYP11B1, CYP11B2

GO Terms for genes affiliated with Adrenal Adenoma

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17Gene Ontology
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Cellular components related to Adrenal Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:0057398.0CYP11A1, CYP17A1, CYP11B1, CYP11B2

Biological processes related to Adrenal Adenoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1aldosterone biosynthetic processGO:0323429.7CYP11B1, CYP11B2
2maternal process involved in female pregnancyGO:0601359.7CYP11A1, MEN1
3cortisol biosynthetic processGO:0346519.7CYP11B2, CYP11B1
4response to gamma radiationGO:0103329.6MEN1, CYP11A1
5mineralocorticoid biosynthetic processGO:0067059.6CYP11B1, CYP11B2
6cellular response to potassium ionGO:0358659.6CYP11B2, CYP11B1
7dibenzo-p-dioxin metabolic processGO:0188949.4CYP17A1, CYP11A1
8biphenyl metabolic processGO:0188799.4CYP17A1, CYP11A1
9response to fungicideGO:0609929.4CYP17A1, CYP11A1
10phthalate metabolic processGO:0189639.4CYP17A1, CYP11A1
11response to insecticideGO:0170859.4CYP11A1, CYP17A1
12phenol-containing compound metabolic processGO:0189589.4CYP17A1, CYP11A1
13glucocorticoid biosynthetic processGO:0067049.3CYP11B1, CYP17A1
14cellular response to hormone stimulusGO:0328709.3CYP11B1, CYP11B2
15cellular response to antibioticGO:0712369.3CYP11A1, CYP17A1
16Leydig cell differentiationGO:0333279.3CYP11A1, CYP17A1
17C21-steroid hormone biosynthetic processGO:0067009.2CYP11A1, CYP11B1, CYP11B2
18cellular response to lipopolysaccharideGO:0712229.1CYP11A1, CYP17A1
19hippocampus developmentGO:0217669.0CYP11A1, CYP17A1
20sterol metabolic processGO:0161258.3CYP11B2, CYP11B1, CYP17A1, CYP11A1
21steroid metabolic processGO:0082028.3CYP17A1, CYP11B2, CYP11B1, CYP11A1
22xenobiotic metabolic processGO:0068058.3CYP17A1, CYP11B1, CYP11B2, CYP11A1
23small molecule metabolic processGO:0442817.7CYP11B2, CYP17A1, CYP11A1, CYP11B1

Molecular functions related to Adrenal Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid 11-beta-monooxygenase activityGO:0045079.3CYP11B2, CYP11B1
2heme bindingGO:0200377.9CYP11B2, CYP11B1, CYP17A1, CYP11A1
3iron ion bindingGO:0055067.7CYP11B2, CYP11B1, CYP17A1, CYP11A1

Products for genes affiliated with Adrenal Adenoma

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Sources for Adrenal Adenoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet