MCID: ADR009
MIFTS: 39

Adrenal Cortex Disease

Categories: Endocrine diseases

Aliases & Classifications for Adrenal Cortex Disease

MalaCards integrated aliases for Adrenal Cortex Disease:

Name: Adrenal Cortex Disease 12 14
Adrenal Cortex Diseases 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3952
MeSH 42 D000303
SNOMED-CT 64 129636003
UMLS 69 C0001614

Summaries for Adrenal Cortex Disease

MalaCards based summary : Adrenal Cortex Disease, also known as adrenal cortex diseases, is related to primary pigmented nodular adrenocortical disease and monosomy 13q34. An important gene associated with Adrenal Cortex Disease is POMC (Proopiomelanocortin), and among its related pathways/superpathways are G alpha (s) signalling events and Corticotropin-releasing hormone signaling pathway. The drugs Galantamine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 72 Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response... more...

Related Diseases for Adrenal Cortex Disease

Diseases related to Adrenal Cortex Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 primary pigmented nodular adrenocortical disease 10.8
2 monosomy 13q34 10.8 POMC REN
3 carotid artery thrombosis 10.8 POMC REN
4 cholangiolocellular carcinoma 10.8 POMC REN
5 spastic ataxia 2 10.7 CYP11B1 CYP11B2
6 functioning pituitary adenoma 10.7 POMC SST
7 prolactin producing pituitary tumor 10.7 POMC SST
8 hypodontia of incisors and premolars 10.6 CYP11B2 POMC REN
9 acute cervicitis 10.6 CRH NR3C1
10 repetitive stress injuries 10.6 REN SST
11 hypodermyasis 10.6 CRH POMC
12 familial hypopituitarism 10.6 NR0B1 POMC REN
13 capillary lymphangioma 10.6 CRH NR0B1 POMC
14 calcinosis 10.6 CRH POMC REN
15 benign peritoneal mesothelioma 10.6 CYP11B1 CYP11B2 POMC
16 mononeuritis of upper limb and mononeuritis multiplex 10.6 PRKAR1A SST
17 keratosis 10.5 CRH NR3C1 POMC
18 traumatic glaucoma 10.5 CRH HSD11B2 POMC
19 renal pelvis carcinoma 10.5 CRH POMC SST
20 marden-walker syndrome 10.5 NR3C2 REN
21 gallbladder adenoma 10.5 CYP11B1 POMC PRKAR1A
22 vallecula cancer 10.5 CRH NR3C1 POMC
23 early-onset parkinson disease 10.5 CRH POMC SST
24 pediatric angiosarcoma 10.5 HSD11B2 POMC REN
25 cutis laxa, autosomal recessive, type ia 10.4 HSD11B2 NR3C1 POMC
26 hypertrichosis 10.4 POMC REN SST
27 hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy 10.4 NR3C2 REN
28 partial motor epilepsy 10.4 CRH NR3C1 POMC
29 febrile infection-related epilepsy syndrome 10.4 CRH POMC
30 aortic valve atresia 10.4 POMC PRL
31 microphthalmia, isolated, with coloboma 7 10.4 CYP11B2 NR3C2 REN
32 first-degree atrioventricular block 10.3 CYP11B1 CYP11B2 POMC REN
33 branchiootorenal/branchiootic syndrome 10.3 CYP11B2 KCNJ5 REN
34 olfactory nerve neoplasm 10.3 POMC PRL
35 long qt syndrome 13 10.3 NR3C2 REN
36 osteoclast-like giant cell neoplasm of the pancreas 10.3 POMC PRL
37 vertebral artery occlusion 10.3 POMC PRL
38 adenocarcinoma 10.3 HSD11B2 NR3C2 REN
39 hereditary cerebral amyloid angiopathy 10.3 CYP11B1 CYP11B2 KCNJ5
40 clear cell acanthoma 10.3 CYP11B1 HSD11B2 POMC REN
41 intermittent squint 10.3 CRH POMC PRL
42 ataxia-oculomotor apraxia 3 10.3 PDE11A POMC PRKAR1A
43 ulcerative blepharitis 10.3 CRH POMC PRL
44 combined t cell and b cell immunodeficiency 10.2 PRL SST
45 craniosynostosis 10.2 CYP11B2 NR3C2 REN
46 euthyroid sick syndrome 10.2 CRH PRL
47 acute myeloid leukemia, susceptibility, gata2-related 10.2 CRH POMC PRL
48 lactic acidosis 10.2 POMC PRL
49 acute gonococcal salpingitis 10.2 CRH POMC PRL
50 allergic asthma 10.2 CRH POMC PRL

Graphical network of the top 20 diseases related to Adrenal Cortex Disease:



Diseases related to Adrenal Cortex Disease

Symptoms & Phenotypes for Adrenal Cortex Disease

MGI Mouse Phenotypes related to Adrenal Cortex Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 NR3C1 NR3C2 PDE11A POMC PRKAR1A PRL
2 homeostasis/metabolism MP:0005376 10.18 AIRE CRH CYP11B1 CYP11B2 HSD11B2 NR0B1
3 cardiovascular system MP:0005385 10.11 CYP11B1 CYP11B2 HSD11B2 KCNJ5 NR3C1 NR3C2
4 growth/size/body region MP:0005378 10.1 AIRE CRH CYP11B1 CYP11B2 NR3C1 NR3C2
5 endocrine/exocrine gland MP:0005379 10.09 AIRE CRH CYP11B1 CYP11B2 NR0B1 NR3C1
6 immune system MP:0005387 9.97 POMC PRKAR1A PRL REN SST AIRE
7 liver/biliary system MP:0005370 9.8 AIRE CRH CYP11B2 NR3C1 POMC PRKAR1A
8 nervous system MP:0003631 9.65 PRL REN SST AIRE CRH CYP11B2
9 neoplasm MP:0002006 9.63 AIRE HSD11B2 NR0B1 POMC PRKAR1A PRL
10 renal/urinary system MP:0005367 9.23 REN CRH CYP11B1 CYP11B2 HSD11B2 NR3C1

Drugs & Therapeutics for Adrenal Cortex Disease

Drugs for Adrenal Cortex Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 486)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Galantamine Approved Phase 4 357-70-0 9651
2
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
3
Nimodipine Approved Phase 4 66085-59-4 4497
4
Daclizumab Approved, Investigational Phase 4 152923-56-3
5
Everolimus Approved Phase 4,Phase 3,Phase 2 159351-69-6 6442177
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
7
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2 53123-88-9 5284616 6436030 46835353
8
Glyburide Approved Phase 4 10238-21-8 3488
9
Gabapentin Approved, Investigational Phase 4,Phase 2 60142-96-3 3446
10
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
11
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
12 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1
13
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
14
Methylphenidate Approved, Investigational Phase 4,Phase 2,Phase 3 113-45-1 4158
15
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
16
Losartan Approved Phase 4 114798-26-4 3961
17
Cosyntropin Approved Phase 4,Phase 1 16960-16-0 16129617
18
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
19
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
20
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
21
Armodafinil Approved, Investigational Phase 4 112111-43-0
22
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
23
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
24
Alprostadil Approved, Investigational Phase 4 745-65-3 149351
25
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
27
Norepinephrine Approved Phase 4 51-41-2 439260
28
Teriparatide Approved, Investigational Phase 4,Phase 2,Phase 3 52232-67-4 16133850
29
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
30
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
31
Ethanol Approved Phase 4 64-17-5 702
32
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
33
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
34
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1 616-91-1 12035
35
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
36
Cilostazol Approved Phase 4 73963-72-1 2754
37
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
38
Choline Approved, Nutraceutical Phase 4 62-49-7 305
39 tannic acid Approved, Nutraceutical Phase 4
40
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2 67-97-0 6221 10883523 5280795
41
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2 50-14-6 5280793
42
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 1406-16-2
43
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 11103-57-4, 68-26-8 445354
44
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
45
gamma-Aminobutyric acid Investigational Phase 4,Phase 2 56-12-2 119
46
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
47
Corticosterone Experimental Phase 4,Phase 1 50-22-6 5753
48 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Cholinergic Agents Phase 4,Phase 2,Early Phase 1
50 Cholinesterase Inhibitors Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 886)

id Name Status NCT ID Phase Drugs
1 Effect of Cognitive Intervention in Alzheimer's Disease (AD) on Functional Cortical Networks in fMRI Unknown status NCT01329601 Phase 4
2 Diffusion Tensor Weighted MRI in Alzheimer's Disease Modifying Treatment Effects of Galantamine (Reminyl®) Unknown status NCT00523666 Phase 4 Galantamine (Reminyl®);Placebo/Galantamine (Reminyl®)
3 Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn) Unknown status NCT02182843 Phase 4
4 Nimodipine for Treating Acute Massive Cerebral Infarction Unknown status NCT02248233 Phase 4 Nimodipine;Saline + citicoline
5 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
6 Fibrosis in Renal Allografts Unknown status NCT00493194 Phase 4 sirolimus;cyclosporine;daclizumab
7 Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia? Unknown status NCT00472875 Phase 4 Glibenclamide
8 Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrome Unknown status NCT02424695 Phase 4 Gabapentin Enacarbil (GEn);Placebo
9 The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder Completed NCT00678574 Phase 4 fluoxetine
10 Angiotensin II Blockade for Chronic Allograft Nephropathy Completed NCT00067990 Phase 4 Losartan 100mg;Placebo
11 Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder Completed NCT00626340 Phase 4 MDD diagnosis and Estrogen treatment;MDD diagnosis and Fluoxetine treatment;MDD diagnosis with both Estrogen and Fluoxetine treatment;No depression and estrogen treatment
12 Revival of Stem Cells in Addison's Study Completed NCT01371526 Phase 4 depot tetracosactide
13 A Study of the Cataractogenic Potential of Seroquel and Risperdal in the Treatment of Participants With Schizophrenia or Schizoaffective Disorder Completed NCT00206102 Phase 4 quetiapine fumarate;risperidone
14 Effects of Paxil CR on Neural Circuits in Posttraumatic Stress Disorder (PTSD) Completed NCT00672776 Phase 4 paroxetine;placebo
15 Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms Completed NCT01919216 Phase 4 Citalopram
16 Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance Completed NCT00711516 Phase 4 Armodafinil;Placebo
17 Effect of High-Dose Vitamin D on Bone Density in Osteogenesis Imperfecta Completed NCT01713231 Phase 4
18 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4 Repository corticotropin injection
19 Lipo-prostaglandin E1 Improves Renal Hypoxia Evaluated by BOLD-MRI in Patients With Diabetic Nephropathy Completed NCT02628106 Phase 4 Lipo-PGE1
20 On the Impact of Bleeding on Two Strategies Osteosynthesis of Trochanteric Fractures Completed NCT01427036 Phase 4
21 Desmopressin Melt: Impact on Sleep and Daytime Functioning Completed NCT01645475 Phase 4 Desmopressin lyophilisate (Melt)
22 Repetitive Transcranial Stimulation (rTMS) in Post Stroke Dysphagia Completed NCT01081444 Phase 4
23 Economic Medical Evaluation of Treatment of the Neuropathic Pain Rebel by Cortical Stimulation Completed NCT00241566 Phase 4
24 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis Completed NCT03152474 Phase 4 Solumedrol 20mg;Vitamin A 100,000 IU
25 Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects Completed NCT02369250 Phase 4 Rosuvastatin
26 HLA Sensitization Following Major Cortical Allograft Bone Procedures Completed NCT00160719 Phase 4
27 A Study To Assess the Quality and Strength of Bone in Women Participants With Osteoporosis Taking Oral Ibandronate Versus Placebo Completed NCT00148915 Phase 4 ibandronate;Placebo
28 Quetiapine Induced Neuroplasticity in First-episode Schizophrenic Patients Completed NCT00554658 Phase 4 Quetiapine
29 A Study To Assess The Quality Of Bone In Patients Taking Oral Ibandronate Versus Placebo Completed NCT02948881 Phase 4 ibandronate
30 Pilot Study of Atomoxetine To Enhance COgnition In Patients With Schizophrenia Completed NCT00488163 Phase 4 Atomoxetine
31 Efficacy of SNRI Treatment on Prefrontality in Patients With GAD and Other Comorbities Recruiting NCT01975480 Phase 4 Desvenlafaxine
32 Effect of Acute Hyperglycemia on Renal Tissue Oxygenation Recruiting NCT02346149 Phase 4
33 Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis Recruiting NCT02765074 Phase 4 subcutaneous tocilizumab
34 Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD Recruiting NCT02977299 Phase 4 Aripiprazole;Venlafaxine XR
35 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
36 Perioperative Mirror Therapy and Phantom Limb Pain Recruiting NCT02383979 Phase 4
37 Analgesic Effect of Non Invasive Stimulation : Comparison of rTMS and tDCS Efficacy Recruiting NCT01800136 Phase 4
38 The Effect of N-Acetyl Cysteine on Cortical Erosion in Early Stage Schizophrenia Active, not recruiting NCT01339858 Phase 4 N-Acetyl Cysteine
39 Efficacy Study of Cilostazol and Aspirin on Cerebral Small Vessel Disease Active, not recruiting NCT01932203 Phase 4 aspirin;cilostazol
40 Effects of Aging and Estrogen on Memory and Cognition Active, not recruiting NCT01268046 Phase 4 Estradiol;Placebo oral capsule
41 A Biotype Enhancing Strategy For The Patient Undergoing Accelerated Orthodontics Enrolling by invitation NCT02866929 Phase 4 Mucograft
42 Effect of Mechanical Loading With PTH on Cortical Bone Not yet recruiting NCT03232476 Phase 4
43 Pain With Trigger Finger Injection: A Comparison of Steroid Alone Versus Steroid/Lidocaine Mixture Terminated NCT02421419 Phase 4 Dexamethasone Sodium Phosphate;Xylocaine;Sodium Chloride
44 Effect of Methylphenidate on Connectivity Withdrawn NCT01764672 Phase 4 Methylphenidate
45 Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects. Withdrawn NCT01006148 Phase 4
46 Cortical Excitability: Phenotype and Biomarker in Attention-deficit, Hyperactivity Disorder (ADHD) Therapy Unknown status NCT01330693 Phase 3 Atomoxetine;Sugar Pill
47 Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride Unknown status NCT00632645 Phase 3 Olanzapine;Xenazine;Tiapridal
48 Essential Fatty Acids in Adult ADHD Unknown status NCT01798381 Phase 3
49 A Novel Non Invasive Brain Stimulation Based Treatment for Chronic Low Back Pain (CLBP) Unknown status NCT02393391 Phase 2, Phase 3
50 Berlin Deep Brain Stimulation Depression Study Unknown status NCT00531726 Phase 3

Search NIH Clinical Center for Adrenal Cortex Disease

Cochrane evidence based reviews: adrenal cortex diseases

Genetic Tests for Adrenal Cortex Disease

Anatomical Context for Adrenal Cortex Disease

MalaCards organs/tissues related to Adrenal Cortex Disease:

39
Brain, Bone, Cortex, Adrenal Cortex, Spinal Cord, Testes, Adrenal Gland

Publications for Adrenal Cortex Disease

Articles related to Adrenal Cortex Disease:

id Title Authors Year
1
Hypertension and adrenal cortex disease. A review of 100 autopsied cases. ( 5491407 )
1970

Variations for Adrenal Cortex Disease

Expression for Adrenal Cortex Disease

Search GEO for disease gene expression data for Adrenal Cortex Disease.

Pathways for Adrenal Cortex Disease

GO Terms for Adrenal Cortex Disease

Biological processes related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.84 CRH HSD11B2 REN SST
2 steroid metabolic process GO:0008202 9.72 CRH CYP11B1 CYP11B2
3 female pregnancy GO:0007565 9.69 CRH HSD11B2 PRL
4 regulation of blood pressure GO:0008217 9.65 CYP11B1 POMC REN
5 steroid biosynthetic process GO:0006694 9.61 CYP11B1 CYP11B2 NR0B1
6 steroid hormone mediated signaling pathway GO:0043401 9.58 NR0B1 NR3C1 NR3C2
7 sterol metabolic process GO:0016125 9.57 CYP11B1 CYP11B2
8 adrenal gland development GO:0030325 9.56 CRH NR0B1
9 hypothalamus development GO:0021854 9.52 CRH NR0B1
10 C21-steroid hormone biosynthetic process GO:0006700 9.49 CYP11B1 CYP11B2
11 cellular response to potassium ion GO:0035865 9.46 CYP11B1 CYP11B2
12 hormone-mediated apoptotic signaling pathway GO:0008628 9.37 CRH SST
13 aldosterone biosynthetic process GO:0032342 9.32 CYP11B1 CYP11B2
14 cortisol biosynthetic process GO:0034651 9.26 CYP11B1 CYP11B2
15 regulation of blood volume by renal aldosterone GO:0002017 9.16 CYP11B2 HSD11B2
16 response to immobilization stress GO:0035902 9.13 CRH NR0B1 REN
17 glucocorticoid biosynthetic process GO:0006704 8.8 CRH CYP11B1 HSD11B2

Molecular functions related to Adrenal Cortex Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.5 NR0B1 NR3C1 NR3C2
2 steroid binding GO:0005496 9.43 HSD11B2 NR3C1 NR3C2
3 corticosterone 18-monooxygenase activity GO:0047783 9.16 CYP11B1 CYP11B2
4 steroid 11-beta-monooxygenase activity GO:0004507 8.96 CYP11B1 CYP11B2
5 hormone activity GO:0005179 8.92 CRH POMC PRL SST

Sources for Adrenal Cortex Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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