Adrenal Cortical Carcinoma malady
Categories: Genetic diseases, Rare diseases, Cancer diseases, Cardiovascular diseases, Nephrological diseases, Reproductive diseases, Endocrine diseases
50OMIM, 34MalaCards, 11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 68UniProtKB/Swiss-Prot, 25GTR, 12diseasecard, 48Novoseek, 37MeSH, 66UMLS, 43NCIt, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet, 35MedGen, 28ICD10, 60SNOMED-CT, 62The Human Phenotype Ontology
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Aliases & Descriptions for Adrenal Cortical Carcinoma:
Orphanet epidemiological data:52
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Childhood
adrenal cortical carcinoma:
Inheritance: autosomal recessive inheritance
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Cardiovascular diseases, Nephrological diseases, Reproductive diseases, Endocrine diseases
ICD10: 29 28
Rare circulatory system diseases
Rare renal diseases
Rare infertility disorders
Rare endocrine diseases
NIH Rare Diseases:46 Adrenocortical carcinoma is a rare cancer affecting the outside of the adrenal glands (adrenal cortex). these glands are on top of each kidney and are responsible for producing certain hormones and keeping blood pressure at normal levels. adrenocortical carcinoma is relatively frequent in children compared to many other cancers, although the cancer may also affect adults. girls are more often affected than boys. symptoms of adrenocortical carcinoma may include pain in the abdomen, hypertension, weight gain, frequent urination and possibly deepening of the voice. these symptoms are due to the tumors causing excess secretion of hormones from the adrenal glands. adrenocortical carcinoma may develop by chance alone, but at least 50% of the cancers are thought to be hereditary. there are a number of genes that have changes (mutations) that can cause an adrenocortical carcinoma, including tp53 and igf2. there have been reports of both autosomal dominant inheritance and autosomal recessive inheritance. an adrenocortical carcinoma is diagnosed based on urine tests for abnormal levels of cortisol, the hormone released by the adrenal glands. blood tests can also be conducted to measure levels of potassium and sodium in the blood. a ct scan or mri may be used to search for a visible tumor in the adrenal cortex. treatment options include surgical removal of the tumor, which is important to achieve a good long-term outlook. chemotherapy, specifically a drug called mitotane, can be used to try to remove any remaining cancer after surgery. last updated: 9/8/2016
MalaCards based summary: Adrenal Cortical Carcinoma, also known as adrenocortical carcinoma, is related to adrenocortical carcinoma with pure aldosterone hypersecretion and adrenal carcinoma, and has symptoms including flank pain and adrenocortical carcinoma. An important gene associated with Adrenal Cortical Carcinoma is TP53 (Tumor Protein P53), and among its related pathways are Corticotropin-releasing hormone and Steroid hormone biosynthesis. Affiliated tissues include cortex, adrenal cortex and adrenal gland, and related mouse phenotypes are muscle and reproductive system.
Disease Ontology:11 An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has material basis in abnormally proliferating cells derives from epithelial cells.
UniProtKB/Swiss-Prot:68 Adrenocortical carcinoma: A malignant neoplasm of the adrenal cortex and a rare childhood tumor. It occurs with increased frequency in patients with Beckwith-Wiedemann syndrome and Li-Fraumeni syndrome.
OMIM:50 Adrenocortical carcinoma (ADCC) is a rare but aggressive childhood tumor, representing about 0.4% of childhood tumors,... (202300) more...
Wikipedia:69 Adrenocortical carcinoma, also adrenal cortical carcinoma (ACC) and adrenal cortex cancer, is an... more...
FDA approved drugs:
Drugs for Adrenal Cortical Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 63)
Interventional clinical trials:(show top 50) (show all 62)
Search NIH Clinical Center for Adrenal Cortical Carcinoma
MalaCards organs/tissues related to Adrenal Cortical Carcinoma:34
Cortex, Adrenal cortex, Adrenal gland, Testes, Kidney, Lung, Breast
MGI Mouse Phenotypes related to Adrenal Cortical Carcinoma:39
Articles related to Adrenal Cortical Carcinoma:(show all 43)
Clinvar genetic disease variations for Adrenal Cortical Carcinoma:5
Cosmic variations for Adrenal Cortical Carcinoma:8 (show top 50) (show all 64)
Copy number variations for Adrenal Cortical Carcinoma from CNVD:6 (show all 23)
Search GEO for disease gene expression data for Adrenal Cortical Carcinoma.
Pathways related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:
Cellular components related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:
Biological processes related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:(show all 14)
Molecular functions related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet