Adrenal Cortical Carcinoma malady

Wikipedia: Adrenocortical carcinoma, also adrenal cortical carcinoma (ACC) and adrenal cortex cancer, is an...⁴⁴ more...

MalaCards: Adrenal Cortical Carcinoma, also known as adrenocortical carcinoma, is related to choroid plexus carcinoma and carcinoma. An important gene associated with Adrenal Cortical Carcinoma is HSD11B2 (hydroxysteroid (11-beta) dehydrogenase 2), and among its related pathways is Cytoskeletal Signaling. The compounds retinoic acid and oxygen have been mentioned in the context of this disorder. Affiliated tissues include cortex, thyroid and adrenal gland, and related mouse phenotypes are normal and muscle.

OMIM: 202300

adrenal cortical carcinoma 7 33 adrenocortical carcinoma 43

Diseases related to adrenal cortical carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 346)

id	Related Disease	Score	Top Affiliating Genes
1	choroid plexus carcinoma	29.3	VIM, TP53
2	carcinoma	28.7	VIM, MUC1, S100B, HSD11B2, TP53, ACTC1
3	li-fraumeni syndrome	28.6	VIM, TP53, ACTC1
4	cushing's syndrome	28.3	MUC1, S100B, HSD11B2, TP53
5	ganglioneuroblastoma	28.1	S100B, TP53
6	renal cell carcinoma	28.0	VIM, MUC1, ACTC1, NKX2-1
7	choroiditis	27.0	VIM, MUC1, S100B, TP53, ACTC1
8	osteosarcoma	26.4	VIM, MUC1, S100B, TP53, DES, NKX2-1
9	retinoblastoma	26.0	VIM, MUC1, S100B, TP53
10	rhabdomyosarcoma	25.9	VIM, S100B, TP53, ACTC1, DES
11	thyroiditis	25.8	VIM, MUC1, S100B, TP53, ACTC1, DES
12	adenoma	25.4	VIM, MUC1, S100B, HSD11B2, TP53, ACTC1
13	adenocarcinoma	25.3	VIM, MUC1, S100B, HSD11B2, TP53, ACTC1
14	squamous cell carcinoma	24.8	VIM, MUC1, S100B, TP53, NKX2-1
15	ovarian small cell carcinoma	13.2	DES, NKX2-1
16	intravenous leiomyomatosis	13.2	ACTC1, DES
17	glomangioma	13.2	ACTC1, DES
18	pulmonary vein stenosis	13.1	ACTC1, DES
19	carney triad	13.1	ACTC1, DES
20	lentigo maligna melanoma	13.1	S100B, NKX2-1
21	botryoid rhabdomyosarcoma	13.1	ACTC1, DES
22	myoma	13.1	ACTC1, DES
23	adenosarcoma	13.1	ACTC1, DES
24	anaplastic ganglioglioma	13.1	S100B, ACTC1
25	familial restrictive cardiomyopathy	13.1	ACTC1, DES
26	orbit embryonal rhabdomyosarcoma	13.1	ACTC1, DES
27	ovarian mucinous neoplasm	13.1	TP53, NKX2-1
28	cavernous hemangioma of face	13.1	ACTC1, DES
29	spiradenoma	13.1	TP53, ACTC1
30	blue rubber bleb nevus syndrome	13.0	S100B, ACTC1
31	follicular dendritic cell tumor	13.0	S100B, ACTC1
32	pulmonary neuroendocrine tumor	13.0	TP53, NKX2-1
33	pigmented villonodular synovitis	13.0	TP53, DES
34	papillary adenocarcinoma	13.0	MUC1, NKX2-1
35	pleomorphic rhabdomyosarcoma	13.0	TP53, DES
36	vulvovaginitis	13.0	ACTC1, DES
37	bile duct adenoma	13.0	TP53, DES
38	cerebral primitive neuroectodermal tumor	13.0	S100B, TP53
39	hypertrophic pyloric stenosis	13.0	S100B, DES
40	spindle cell thymoma	13.0	MUC1, DES
41	desmoplastic small round cell tumor	13.0	MUC1, DES
42	gemistocytic astrocytoma	13.0	S100B, TP53
43	merkel cell carcinoma	13.0	MUC1, NKX2-1
44	nodular melanoma	12.9	S100B, TP53
45	large cell carcinoma	12.9	TP53, NKX2-1
46	dysembryoplastic neuroepithelial tumor	12.9	S100B, TP53
47	central neurocytoma	12.9	S100B, TP53
48	tubular adenocarcinoma	12.9	MUC1, ACTC1
49	intraneural perineurioma	12.9	MUC1, S100B
50	malignant pleural mesothelioma	12.9	MUC1, NKX2-1

Clinical features from OMIM: 202300

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to adrenal cortical carcinoma:

²²

MGI Mouse Phenotypes related to adrenal cortical carcinoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	10.1	HSD11B2
2	muscle phenotype	MP:0005369	8.0	DES, ACTC1, TP53, HSD11B2, VIM
3	behavior/neurological phenotype	MP:0005386	7.9	VIM, S100B, HSD11B2, DES, NKX2-1
4	cardiovascular system phenotype	MP:0005385	7.7	NKX2-1, DES, ACTC1, TP53, HSD11B2, VIM
5	homeostasis/metabolism phenotype	MP:0005376	7.0	VIM, NKX2-1, DES, ACTC1, TP53, HSD11B2

Articles related to adrenal cortical carcinoma:

id	Title	Authors	Year	Affiliating Genes
1	Non-functioning adrenal cortical carcinoma presenting with metastasis to the tongue. (12581389)	Dominici A.... Franchi A.	2003	S100B, VIM, DES
2	Comparison of thyroid transcription factor-1 and hepatocyte antigen immunohistochemical analysis in the differential diagnosis of hepatocellular carcinoma, metastatic adenocarcinoma, renal cell carcinoma, and adrenal cortical carcinoma. (12472285)	Wieczorek T.J.... Pinkus G.S.	2002	NKX2-1
3	An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. (12236151)	McDougal W.S.	2002	TP53
4	An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. (11481490)	Ribeiro R.C.... Sandrini R.	2001	TP53
5	Expression of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD-2) in the developing human adrenal gland and human adrenal cortical carcinoma and adenoma. (10509802)	Coulter C.L.... Gordon R.D.	1999	HSD11B2
6	Novel germline mutation of the p53 tumor suppressor gene in a child with incidentally discovered adrenal cortical carcinoma. (7978053)	Grayson G.H.... Hensel C.H.	1994	TP53

Genes related to adrenal cortical carcinoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0	Functions, Publications
2	NKX2-1	NK2 homeobox 1	11.0	Publications
3	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
4	DES	desmin	11.0	Publications
5	S100B	S100 calcium binding protein B	11.0	Publications
6	VIM	vimentin	11.0	Publications
7	MUC1	mucin 1, cell surface associated	11.0	Publications
8	TP53	tumor protein p53	11.0	Publications

Pathways related to adrenal cortical carcinoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeletal Signaling3	9.0	VIM, ACTC1, DES

Compounds related to adrenal cortical carcinoma according to GeneDecks:

(show top 50)    (show all 56)

id	Compound	Score	Top Affiliating Genes
1	retinoic acid32 42 18	12.4	S100B
2	oxygen32 18	11.1	HSD11B2, ACTC1
3	2-methoxyethanol32	9.7	VIM, ACTC1
4	toluidine32	9.6	VIM, DES
5	aristolochic acid32	9.4	VIM, TP53
6	cysteine32	9.4	MUC1, S100B
7	phalloidin32	9.4	VIM, DES
8	procollagen32	9.3	DES, ACTC1, VIM
9	temozolomide32 9 9	11.2	TP53, VIM
10	imatinib32 34 9 9	12.2	DES, ACTC1, S100B
11	bromodeoxyuridine32	9.1	DES, S100B, VIM
12	hydrocortisone32 9 9	11.0	VIM, MUC1, HSD11B2
13	eosin32	8.9	S100B, MUC1, VIM
14	progestin32	8.9	VIM, MUC1, DES
15	orcein32	8.9	DES, ACTC1, S100B, VIM
16	ribonucleic acid32	8.9	MUC1, HSD11B2, ACTC1, NKX2-1
17	cytarabine32 34 9 9	11.8	VIM, MUC1, TP53
18	acth32	8.8	MUC1, S100B, HSD11B2
19	iron32 18	9.8	DES, ACTC1, S100B, VIM
20	steroid32	8.7	NKX2-1, DES, ACTC1, HSD11B2, S100B
21	hyaluronic acid32 18	9.7	VIM, MUC1, DES
22	adenylate32	8.7	DES, HSD11B2, S100B, VIM
23	proline32	8.7	DES, TP53, S100B, VIM
24	dihydrotestosterone32 9 18 9	11.6	DES, HSD11B2, MUC1, VIM
25	biotin32 9 18 9	11.6	DES, ACTC1, MUC1, VIM
26	estradiol32 9 18 9	11.6	DES, HSD11B2, MUC1, VIM
27	butyrate32	8.5	VIM, MUC1, HSD11B2, TP53
28	adriamycin32	8.4	VIM, MUC1, TP53, DES
29	thymidine32 18	9.4	DES, TP53, S100B, MUC1
30	arginine32	8.4	DES, TP53, HSD11B2, S100B, VIM
31	chloramphenicol32 9 9	10.2	VIM, MUC1, S100B
32	glucose32	8.2	DES, ACTC1, HSD11B2, S100B, MUC1
33	forskolin32 42 9 9	11.2	NKX2-1, HSD11B2, S100B, MUC1, VIM
34	actinomycin d32	8.1	DES, TP53, HSD11B2, MUC1, VIM
35	s 10032	8.1	DES, ACTC1, S100B, MUC1, VIM
36	reticulin32	8.1	DES, ACTC1, S100B, MUC1, VIM
37	cyclic amp32 18	9.1	NKX2-1, DES, S100B, MUC1, VIM
38	glycogen32 18	9.1	DES, ACTC1, S100B, MUC1, VIM
39	testosterone32 9 18 9	11.0	DES, ACTC1, S100B, MUC1, VIM
40	dexamethasone32 42 34 9 9	11.8	NKX2-1, ACTC1, HSD11B2, S100B, MUC1, VIM
41	creatinine32	7.7	DES, ACTC1, HSD11B2, S100B, MUC1, VIM
42	mucicarmine32	7.7	VIM, MUC1, S100B, ACTC1, DES, NKX2-1
43	b 72332	7.7	NKX2-1, DES, ACTC1, S100B, MUC1, VIM
44	hematoxylin32	7.7	NKX2-1, DES, ACTC1, S100B, MUC1, VIM
45	formaldehyde32 18	8.7	NKX2-1, DES, ACTC1, S100B, MUC1, VIM
46	vegf32	7.5	DES, ACTC1, TP53, S100B, MUC1, VIM
47	serine32	7.2	NKX2-1, DES, TP53, HSD11B2, S100B, MUC1
48	paraffin32	7.2	NKX2-1, DES, ACTC1, TP53, S100B, MUC1
49	progesterone32 42 9 18 9	10.8	NKX2-1, DES, ACTC1, TP53, HSD11B2, S100B
50	estrogen32	6.8	NKX2-1, DES, ACTC1, TP53, HSD11B2, S100B

Biological processes related to adrenal cortical carcinoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	9.1	MUC1, TP53
2	muscle filament sliding	GO:030049	8.7	VIM, ACTC1, DES