MCID: ADR016
MIFTS: 46

Adrenal Cortical Carcinoma malady

Genetic diseases (common), Endocrine diseases, Cancer diseases categories

Summaries for Adrenal Cortical Carcinoma

About this section


OMIM:45 Adrenocortical carcinoma (ADCC) is a rare but aggressive childhood tumor, representing about 0.4% of childhood tumors,... (202300) more...

MalaCards based summary: Adrenal Cortical Carcinoma, also known as adrenocortical carcinoma, hereditary, is related to renal cell carcinoma and adrenocortical carcinoma, and has symptoms including autosomal recessive inheritanceand adrenocortical carcinoma. An important gene associated with Adrenal Cortical Carcinoma is TP53 (tumor protein p53), and among its related pathways are Aurora B signaling and EGFR Signaling Pathway. The compounds 2-methoxyethanol and toluidine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, adrenal gland and tongue, and related mouse phenotypes are tumorigenesis and muscle.

Aliases & Classifications for Adrenal Cortical Carcinoma

About this section

Adrenal Cortical Carcinoma, Aliases & Descriptions:

Name: Adrenal Cortical Carcinoma 45 10
Adrenocortical Carcinoma, Hereditary 45 22
 
Adrenocortical Carcinoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Endocrine diseases


External Ids:

OMIM45 202300

Related Diseases for Adrenal Cortical Carcinoma

About this section

Diseases related to Adrenal Cortical Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma31.0TP53
2adrenocortical carcinoma30.9HSD11B2, TP53
3angiosarcoma30.1VIM, ACTC1, MUC1
4adenoma30.0ACTC1, NKX2-1, HSD11B2, TP53, MUC1
5adenocarcinoma29.3MUC1, VIM, TP53, NKX2-1, ACTC1, HSD11B2
6hyperaldosteronism10.5
7pulmonary blastoma10.5NKX2-1
8fasciitis10.5ACTC1
9ductal carcinoma in situ10.5TP53
10adenomatoid tumor10.5VIM
11infantile myofibromatosis10.4DES
12gemistocytic astrocytoma10.4S100B
13histiocytosis10.3S100B
14ganglioglioma10.3S100B
15papilloma10.3ACTC1, TP53
16adrenal cortical adenoma10.3
17eccrine porocarcinoma10.3MUC1
18hemangioma10.3NKX2-1, ACTC1
19hidradenoma10.3MUC1
20benign mesothelioma10.3TP53, NKX2-1
21cystadenocarcinoma10.3MUC1
22desmoid disease, hereditary10.2DES, ACTC1
23adenosarcoma10.2DES, ACTC1
24thyroid cancer, anaplastic10.2NKX2-1, TP53
25embryonal rhabdomyosarcoma10.2DES, ACTC1
26alveolar soft-part sarcoma10.2VIM, DES
27teratoma10.2NKX2-1, ACTC1
28hepatocellular carcinoma10.2
29pheochromocytoma10.2
30luteoma10.2
31von willebrand's disease10.2
32cushing's syndrome10.2
33thyroiditis10.2
34malignant peripheral nerve sheath tumor10.1VIM, S100B
35papillary adenocarcinoma10.1MUC1, NKX2-1
36clear cell ependymoma10.1VIM, MUC1
37tubular adenocarcinoma10.1ACTC1, MUC1
38thymic carcinoma10.1MUC1, NKX2-1
39desmoplastic small round cell tumor10.1DES, MUC1
40lung cancer10.1HSD11B2, TP53, NKX2-1
41merkel cell carcinoma10.1MUC1, NKX2-1
42endometrial cancer10.1TP53, MUC1
43syringoma10.1S100B, MUC1
44glomus tumor10.1VIM, ACTC1, DES
45liposarcoma10.1DES, VIM, TP53
46epithelioid sarcoma10.0MUC1, VIM
47fibrous meningioma10.0S100B, MUC1
48epithelioid leiomyosarcoma10.0ACTC1, VIM, DES
49mucoepidermoid carcinoma10.0MUC1, ACTC1
50pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1

Graphical network of the top 20 diseases related to Adrenal Cortical Carcinoma:



Diseases related to adrenal cortical carcinoma

Symptoms for Adrenal Cortical Carcinoma

About this section

Symptoms by clinical synopsis from OMIM:

202300

Clinical features from OMIM:

202300

HPO human phenotypes related to Adrenal Cortical Carcinoma:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 adrenocortical carcinoma HP:0006744

Drugs & Therapeutics for Adrenal Cortical Carcinoma

About this section

Drug clinical trials:

Search ClinicalTrials for Adrenal Cortical Carcinoma

Search NIH Clinical Center for Adrenal Cortical Carcinoma

Genetic Tests for Adrenal Cortical Carcinoma

About this section

Genetic tests related to Adrenal Cortical Carcinoma:

id Genetic test Affiliating Genes
1 Adrenocortical Carcinoma, Hereditary22

Anatomical Context for Adrenal Cortical Carcinoma

About this section

MalaCards organs/tissues related to Adrenal Cortical Carcinoma:

31
Thyroid, Adrenal gland, Tongue

Animal Models for Adrenal Cortical Carcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Adrenal Cortical Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5NKX2-1, MUC1, TP53, HSD11B2
2MP:00053698.5DES, HSD11B2, TP53, VIM, ACTC1
3MP:00030128.4HSD11B2, TP53, MUC1, NKX2-1
4MP:00053848.4NKX2-1, ACTC1, VIM, TP53, HSD11B2
5MP:00053818.2HSD11B2, TP53, MUC1, NKX2-1
6MP:00053858.0DES, HSD11B2, TP53, VIM, ACTC1, NKX2-1
7MP:00028738.0HSD11B2, TP53, MUC1, ACTC1, S100B
8MP:00107687.8DES, HSD11B2, TP53, VIM, ACTC1, NKX2-1
9MP:00053867.8DES, HSD11B2, TP53, VIM, NKX2-1, S100B
10MP:00053767.2NKX2-1, DES, HSD11B2, TP53, VIM, MUC1

Publications for Adrenal Cortical Carcinoma

About this section

Articles related to Adrenal Cortical Carcinoma:

(show all 20)
idTitleAuthorsYear
1
Adrenal cortical adenoma with the maximal diameter greater than 5 cm: can they be differentiated from adrenal cortical carcinoma by CT? (25419344)
2014
2
A Mimic of Sarcomatoid Adrenal Cortical Carcinoma: Epithelioid Angiosarcoma Occurring in Adrenal Cortical Adenoma. (25246132)
2014
3
Adrenal cortical carcinoma masquerading as pheochromocytoma: a case report. (23152728)
2012
4
Adrenal cortical carcinoma with late pulmonary metastases causing clinicical Cushing's syndrome: case report with immunohistochemical analysis of steriodogenic enzyme production. (22784838)
2012
5
Carney complex with adrenal cortical carcinoma. (22112809)
2012
6
Myxoid adrenal cortical carcinoma presenting as primary hyperaldosteronism: case report and review of the literature. (20444728)
2011
7
Myxoid adrenal cortical carcinoma--a rare variant of adrenocortical carcinoma. (16340152)
2005
8
Hyperaldosteronism and hyperprogesteronism in a cat with an adrenal cortical carcinoma. (15954552)
2005
9
Non-functioning adrenal cortical carcinoma presenting with metastasis to the tongue. (12581389)
2003
10
An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. (12236151)
2002
11
Comparison of thyroid transcription factor-1 and hepatocyte antigen immunohistochemical analysis in the differential diagnosis of hepatocellular carcinoma, metastatic adenocarcinoma, renal cell carcinoma, and adrenal cortical carcinoma. (12472285)
2002
12
An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. (11481490)
2001
13
Use of electron microscopic evaluation for the diagnosis of adrenal cortical carcinoma in fine needle aspiration cytology: a case report and review of the literature. (11793196)
2001
14
Expression of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD-2) in the developing human adrenal gland and human adrenal cortical carcinoma and adenoma. (10509802)
1999
15
Novel germline mutation of the p53 tumor suppressor gene in a child with incidentally discovered adrenal cortical carcinoma. (7978053)
1994
16
Primary hyperaldosteronism: due to adrenal cortical carcinoma. (8323523)
1993
17
Acquired type II von Willebrand's disease associated with adrenal cortical carcinoma. (1581233)
1992
18
Pure primary hyperaldosteronism due to adrenal cortical carcinoma. (4025371)
1985
19
Pure primary hyperaldosteronism due to adrenal cortical carcinoma. (6375367)
1984
20
In vivo and in vitro studies of steroid production by a luteoma and an adrenal cortical carcinoma in mice. (4304996)
1969

Variations for Adrenal Cortical Carcinoma

About this section

Expression for genes affiliated with Adrenal Cortical Carcinoma

About this section
Search GEO for disease gene expression data for Adrenal Cortical Carcinoma.

Pathways for genes affiliated with Adrenal Cortical Carcinoma

About this section

Pathways related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.4DES, VIM
29.3MUC1, TP53
3
Show member pathways
9.0ACTC1, VIM, DES
49.0ACTC1, VIM, DES
5
Show member pathways
8.3MUC1, VIM, TP53, DES

Compounds for genes affiliated with Adrenal Cortical Carcinoma

About this section

Compounds related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
12-methoxyethanol439.7ACTC1, VIM
2toluidine439.5DES, VIM
3aristolochic acid43 210.5VIM, TP53
4procollagen439.3DES, ACTC1, VIM
5imatinib43 49 1211.1DES, S100B, ACTC1
6cytarabine43 49 1211.1TP53, VIM, MUC1
7bromodeoxyuridine439.0S100B, DES, VIM
8hydrocortisone43 2 59 1212.0HSD11B2, VIM, MUC1
9eosin438.9VIM, MUC1, S100B
10progestin438.9DES, MUC1, VIM
11orcein438.8VIM, ACTC1, S100B, DES
12hyaluronic acid43 249.8VIM, DES, MUC1
13ribonucleic acid438.8HSD11B2, NKX2-1, ACTC1, MUC1
14proline438.8S100B, TP53, VIM, DES
15butyrate438.8VIM, HSD11B2, MUC1, TP53
16acth438.7HSD11B2, S100B, MUC1
17iron43 249.7DES, VIM, ACTC1, S100B
18adenylate438.7HSD11B2, DES, S100B, VIM
19adriamycin438.7VIM, MUC1, DES, TP53
20dihydrotestosterone43 28 24 1211.6DES, MUC1, VIM, HSD11B2
21biotin43 24 1210.6VIM, DES, ACTC1, MUC1
22estradiol43 24 1210.6MUC1, VIM, DES, HSD11B2
23steroid438.5HSD11B2, S100B, DES, NKX2-1, ACTC1
24arginine438.5S100B, TP53, DES, VIM, HSD11B2
25thymidine43 249.4S100B, TP53, DES, MUC1
26actinomycin d438.3MUC1, TP53, DES, VIM, HSD11B2
27chloramphenicol43 2 49 1211.2VIM, S100B, MUC1
28forskolin43 49 1210.1HSD11B2, S100B, NKX2-1, MUC1, VIM
29oxygen43 249.1DES, MUC1, ACTC1, S100B, HSD11B2
30glucose438.1ACTC1, MUC1, S100B, DES, HSD11B2
31threonine438.1MUC1, DES, NKX2-1, S100B
32s 100438.0ACTC1, VIM, MUC1, S100B, DES
33reticulin438.0VIM, S100B, MUC1, DES, ACTC1
34glycogen43 249.0DES, S100B, ACTC1, MUC1, VIM
35cysteine438.0MUC1, S100B, VIM, DES, HSD11B2
36testosterone43 59 24 1211.0DES, VIM, ACTC1, S100B, MUC1
37cyclic amp43 248.9DES, NKX2-1, S100B, MUC1, VIM
38dexamethasone43 49 28 1210.7ACTC1, MUC1, HSD11B2, S100B, NKX2-1, VIM
39vegf437.6VIM, MUC1, ACTC1, S100B, TP53, DES
40tyrosine437.6DES, S100B, NKX2-1, ACTC1, MUC1
41creatinine437.6ACTC1, DES, HSD11B2, VIM, MUC1, S100B
42mucicarmine437.6ACTC1, VIM, S100B, NKX2-1, MUC1, DES
43b 723437.6S100B, NKX2-1, MUC1, DES, ACTC1, VIM
44hematoxylin437.6S100B, ACTC1, MUC1, NKX2-1, DES, VIM
45formaldehyde43 248.6VIM, DES, S100B, NKX2-1, ACTC1, MUC1
46serine437.2HSD11B2, DES, MUC1, TP53, NKX2-1, VIM
47paraffin437.2DES, VIM, MUC1, ACTC1, S100B, NKX2-1
48retinoic acid43 248.2DES, MUC1, S100B, ACTC1, VIM, TP53
49progesterone43 28 59 24 1210.8S100B, VIM, MUC1, ACTC1, NKX2-1, TP53
50estrogen436.8VIM, ACTC1, HSD11B2, DES, TP53, NKX2-1

GO Terms for genes affiliated with Adrenal Cortical Carcinoma

About this section

Biological processes related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to glucocorticoidGO:00513849.5S100B, HSD11B2
2negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305129.4NKX2-1, TP53
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.3MUC1, TP53
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.2TP53, MUC1
5muscle filament slidingGO:00300499.1ACTC1, VIM, DES

Molecular functions related to Adrenal Cortical Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.3MUC1, TP53
2identical protein bindingGO:00428028.2S100B, VIM, TP53, DES

Products for genes affiliated with Adrenal Cortical Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Adrenal Cortical Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet